Overview

  • Threshold analysis run on four HIV vaccine trials: HVTN705, HVTN702, HVTN505, and RV144, as well as HVTN 705 + RV144 combined.
  • Analyses run on vaccine participants only. (Marker variable values were missing or 0 for most placebo participants in each study.)
  • Thresholds were selected over a grid of increments of 0.1, from the lowest marker value to the highest value of the marker such that there are at least 3 endpoints with a marker at least that value
  • Reference timepoint was chosen as the timepoint of the latest endpoint
  • For VE graphs, placebo risk was determined by using all data from the placebo arm, regardless of whether the marker was sampled. Note: For HVTN705, there are 210 placebo participants missing their event/censoring time variable. These are excluded when calculating the placebo risk.
  • Vaccine efficacy confidence intervals cutoffs between -1 and 1.

HVTN 705

  • Adjustment covariates: Age, RSA, BMI, Riskscore
  • Event time variable: Ttilde.D210
  • Event type variable: Delta.D210
  • Weight variable: wt.D210
  • Reference timepoint: 552 days
  • Filter: !is.na(Ttilde.D210)
  • All learners: GLM

IgG V1V2 B.CaseA-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.0515 0.00678 0.03820 0.0648
0.1 0.9030 1.26 0.0496 0.00777 0.03440 0.0648
0.2 0.9030 1.58 0.0496 0.00777 0.03440 0.0648
0.3 0.9030 2.00 0.0496 0.00777 0.03440 0.0648
0.4 0.9030 2.51 0.0496 0.00777 0.03440 0.0648
0.5 0.9030 3.16 0.0496 0.00777 0.03440 0.0648
0.6 0.9030 3.98 0.0496 0.00777 0.03440 0.0648
0.7 0.9030 5.01 0.0496 0.00777 0.03440 0.0648
0.8 0.9030 6.31 0.0496 0.00777 0.03440 0.0648
0.9 0.9030 7.94 0.0496 0.00777 0.03440 0.0648
1.0 0.9030 10.00 0.0496 0.00777 0.03440 0.0648
1.1 0.8980 12.60 0.0496 0.00782 0.03430 0.0649
1.2 0.8810 15.80 0.0496 0.00794 0.03400 0.0652
1.3 0.8810 20.00 0.0496 0.00794 0.03400 0.0652
1.4 0.8810 25.10 0.0496 0.00794 0.03400 0.0652
1.5 0.8700 31.60 0.0496 0.00803 0.03390 0.0653
1.6 0.8550 39.80 0.0496 0.00814 0.03360 0.0656
1.7 0.8280 50.10 0.0496 0.00815 0.03360 0.0656
1.8 0.8080 63.10 0.0496 0.00818 0.03360 0.0656
1.9 0.8040 79.40 0.0496 0.00813 0.03370 0.0655
2.0 0.7830 100.00 0.0496 0.00825 0.03340 0.0658
2.1 0.7690 126.00 0.0496 0.00825 0.03340 0.0658
2.2 0.7570 158.00 0.0496 0.00837 0.03320 0.0660
2.3 0.7350 200.00 0.0496 0.00853 0.03290 0.0663
2.4 0.7010 251.00 0.0496 0.00875 0.03240 0.0668
2.5 0.6830 316.00 0.0496 0.00879 0.03240 0.0668
2.6 0.6420 398.00 0.0496 0.00929 0.03140 0.0678
2.7 0.5890 501.00 0.0496 0.01020 0.02970 0.0695
2.8 0.5410 631.00 0.0496 0.01080 0.02840 0.0708
2.9 0.5110 794.00 0.0496 0.01090 0.02830 0.0709
3.0 0.4690 1000.00 0.0496 0.01110 0.02790 0.0713
3.1 0.4250 1260.00 0.0433 0.01090 0.02200 0.0646
3.2 0.4020 1580.00 0.0424 0.01050 0.02180 0.0631
3.3 0.3520 2000.00 0.0424 0.01170 0.01940 0.0655
3.4 0.3250 2510.00 0.0424 0.01130 0.02020 0.0647
3.5 0.2940 3160.00 0.0424 0.01280 0.01730 0.0676
3.6 0.2680 3980.00 0.0424 0.01440 0.01420 0.0707
3.7 0.2340 5010.00 0.0424 0.01500 0.01300 0.0719
3.8 0.2060 6310.00 0.0424 0.01580 0.01140 0.0735
3.9 0.1750 7940.00 0.0424 0.01510 0.01290 0.0720
4.0 0.1360 10000.00 0.0424 0.02220 -0.00115 0.0860
4.1 0.1190 12600.00 0.0424 0.02860 -0.01360 0.0985
4.2 0.0917 15800.00 0.0424 0.03270 -0.02160 0.1060
4.3 0.0722 20000.00 0.0348 0.02780 -0.01970 0.0892

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.0515 0.00678 0.03570 0.0650
0.1 1.26 0.9030 0.0490 0.00777 0.03380 0.0643
0.2 1.58 0.9030 0.0490 0.00777 0.03380 0.0643
0.3 2.00 0.9030 0.0490 0.00777 0.03380 0.0643
0.4 2.51 0.9030 0.0490 0.00777 0.03380 0.0643
0.5 3.16 0.9030 0.0490 0.00777 0.03380 0.0643
0.6 3.98 0.9030 0.0490 0.00777 0.03380 0.0643
0.7 5.01 0.9030 0.0490 0.00777 0.03380 0.0643
0.8 6.31 0.9030 0.0490 0.00777 0.03380 0.0643
0.9 7.94 0.9030 0.0490 0.00777 0.03380 0.0643
1.0 10.00 0.9030 0.0490 0.00777 0.03380 0.0643
1.1 12.60 0.8980 0.0493 0.00782 0.03400 0.0646
1.2 15.80 0.8810 0.0501 0.00794 0.03450 0.0656
1.3 20.00 0.8810 0.0501 0.00794 0.03450 0.0656
1.4 25.10 0.8810 0.0501 0.00794 0.03450 0.0656
1.5 31.60 0.8700 0.0506 0.00803 0.03480 0.0663
1.6 39.80 0.8550 0.0508 0.00814 0.03490 0.0668
1.7 50.10 0.8280 0.0499 0.00815 0.03390 0.0659
1.8 63.10 0.8080 0.0490 0.00818 0.03300 0.0651
1.9 79.40 0.8040 0.0482 0.00813 0.03220 0.0641
2.0 100.00 0.7830 0.0484 0.00825 0.03220 0.0646
2.1 126.00 0.7690 0.0477 0.00825 0.03150 0.0639
2.2 158.00 0.7570 0.0484 0.00837 0.03200 0.0648
2.3 200.00 0.7350 0.0486 0.00853 0.03180 0.0653
2.4 251.00 0.7010 0.0483 0.00875 0.03110 0.0654
2.5 316.00 0.6830 0.0478 0.00879 0.03060 0.0650
2.6 398.00 0.6420 0.0495 0.00929 0.03130 0.0677
2.7 501.00 0.5890 0.0535 0.01020 0.03360 0.0734
2.8 631.00 0.5410 0.0562 0.01080 0.03500 0.0775
2.9 794.00 0.5110 0.0533 0.01090 0.03200 0.0746
3.0 1000.00 0.4690 0.0501 0.01110 0.02840 0.0718
3.1 1260.00 0.4250 0.0433 0.01090 0.02200 0.0646
3.2 1580.00 0.4020 0.0410 0.01050 0.02040 0.0616
3.3 2000.00 0.3520 0.0425 0.01170 0.01950 0.0655
3.4 2510.00 0.3250 0.0381 0.01130 0.01580 0.0603
3.5 3160.00 0.2940 0.0429 0.01280 0.01780 0.0680
3.6 3980.00 0.2680 0.0461 0.01440 0.01780 0.0744
3.7 5010.00 0.2340 0.0450 0.01500 0.01550 0.0744
3.8 6310.00 0.2060 0.0427 0.01580 0.01170 0.0738
3.9 7940.00 0.1750 0.0325 0.01510 0.00291 0.0620
4.0 10000.00 0.1360 0.0451 0.02220 0.00149 0.0887
4.1 12600.00 0.1190 0.0511 0.02860 -0.00500 0.1070
4.2 15800.00 0.0917 0.0514 0.03270 -0.01260 0.1150
4.3 20000.00 0.0722 0.0348 0.02780 -0.01970 0.0892

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.122 0.157 -0.186 0.430
0.1 0.9030 1.26 0.155 0.168 -0.174 0.483
0.2 0.9030 1.58 0.155 0.168 -0.174 0.483
0.3 0.9030 2.00 0.155 0.168 -0.174 0.483
0.4 0.9030 2.51 0.155 0.168 -0.174 0.483
0.5 0.9030 3.16 0.155 0.168 -0.174 0.483
0.6 0.9030 3.98 0.155 0.168 -0.174 0.483
0.7 0.9030 5.01 0.155 0.168 -0.174 0.483
0.8 0.9030 6.31 0.155 0.168 -0.174 0.483
0.9 0.9030 7.94 0.155 0.168 -0.174 0.483
1.0 0.9030 10.00 0.155 0.168 -0.174 0.483
1.1 0.8980 12.60 0.155 0.168 -0.175 0.484
1.2 0.8810 15.80 0.155 0.170 -0.178 0.488
1.3 0.8810 20.00 0.155 0.170 -0.178 0.488
1.4 0.8810 25.10 0.155 0.170 -0.178 0.488
1.5 0.8700 31.60 0.155 0.171 -0.181 0.490
1.6 0.8550 39.80 0.155 0.173 -0.183 0.493
1.7 0.8280 50.10 0.155 0.173 -0.184 0.493
1.8 0.8080 63.10 0.155 0.173 -0.185 0.494
1.9 0.8040 79.40 0.155 0.172 -0.183 0.493
2.0 0.7830 100.00 0.155 0.174 -0.186 0.496
2.1 0.7690 126.00 0.155 0.174 -0.186 0.496
2.2 0.7570 158.00 0.155 0.176 -0.190 0.499
2.3 0.7350 200.00 0.155 0.178 -0.194 0.504
2.4 0.7010 251.00 0.155 0.181 -0.200 0.510
2.5 0.6830 316.00 0.155 0.182 -0.201 0.511
2.6 0.6420 398.00 0.155 0.189 -0.215 0.525
2.7 0.5890 501.00 0.155 0.201 -0.240 0.549
2.8 0.5410 631.00 0.155 0.211 -0.259 0.569
2.9 0.5110 794.00 0.155 0.212 -0.260 0.570
3.0 0.4690 1000.00 0.155 0.215 -0.266 0.575
3.1 0.4250 1260.00 0.262 0.206 -0.141 0.665
3.2 0.4020 1580.00 0.277 0.200 -0.115 0.668
3.3 0.3520 2000.00 0.277 0.219 -0.152 0.705
3.4 0.3250 2510.00 0.277 0.212 -0.140 0.693
3.5 0.2940 3160.00 0.277 0.236 -0.185 0.738
3.6 0.2680 3980.00 0.277 0.261 -0.235 0.788
3.7 0.2340 5010.00 0.277 0.271 -0.253 0.807
3.8 0.2060 6310.00 0.277 0.284 -0.280 0.833
3.9 0.1750 7940.00 0.277 0.272 -0.256 0.809
4.0 0.1360 10000.00 0.277 0.389 -0.486 1.040
4.1 0.1190 12600.00 0.277 0.495 -0.694 1.250
4.2 0.0917 15800.00 0.277 0.563 -0.827 1.380
4.3 0.0722 20000.00 0.408 0.479 -0.531 1.350

IgG V1V2 AE.A244-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.0515 0.00678 0.03820 0.0648
0.1 0.993 1.26 0.0511 0.00741 0.03660 0.0657
0.2 0.993 1.58 0.0511 0.00741 0.03660 0.0657
0.3 0.993 2.00 0.0511 0.00741 0.03660 0.0657
0.4 0.993 2.51 0.0511 0.00741 0.03660 0.0657
0.5 0.993 3.16 0.0511 0.00741 0.03660 0.0657
0.6 0.993 3.98 0.0511 0.00741 0.03660 0.0657
0.7 0.992 5.01 0.0511 0.00733 0.03680 0.0655
0.8 0.992 6.31 0.0511 0.00733 0.03680 0.0655
0.9 0.992 7.94 0.0511 0.00733 0.03680 0.0655
1.0 0.992 10.00 0.0511 0.00733 0.03680 0.0655
1.1 0.989 12.60 0.0511 0.00730 0.03680 0.0654
1.2 0.986 15.80 0.0511 0.00733 0.03680 0.0655
1.3 0.986 20.00 0.0511 0.00733 0.03680 0.0655
1.4 0.978 25.10 0.0511 0.00740 0.03660 0.0656
1.5 0.972 31.60 0.0511 0.00747 0.03650 0.0658
1.6 0.969 39.80 0.0511 0.00749 0.03640 0.0658
1.7 0.966 50.10 0.0511 0.00752 0.03640 0.0659
1.8 0.958 63.10 0.0511 0.00760 0.03620 0.0660
1.9 0.949 79.40 0.0511 0.00768 0.03610 0.0662
2.0 0.946 100.00 0.0511 0.00764 0.03620 0.0661
2.1 0.916 126.00 0.0511 0.00784 0.03580 0.0665
2.2 0.872 158.00 0.0511 0.00823 0.03500 0.0673
2.3 0.854 200.00 0.0511 0.00828 0.03490 0.0674
2.4 0.800 251.00 0.0511 0.00888 0.03370 0.0685
2.5 0.740 316.00 0.0511 0.00936 0.03280 0.0695
2.6 0.694 398.00 0.0511 0.00965 0.03220 0.0700
2.7 0.613 501.00 0.0511 0.01050 0.03050 0.0718
2.8 0.564 631.00 0.0511 0.01060 0.03040 0.0719
2.9 0.508 794.00 0.0511 0.01130 0.02910 0.0732
3.0 0.436 1000.00 0.0511 0.01270 0.02620 0.0761
3.1 0.351 1260.00 0.0511 0.01530 0.02120 0.0811
3.2 0.291 1580.00 0.0511 0.01670 0.01850 0.0838
3.3 0.239 2000.00 0.0511 0.01780 0.01620 0.0861
3.4 0.184 2510.00 0.0403 0.01570 0.00952 0.0710
3.5 0.154 3160.00 0.0353 0.01530 0.00519 0.0653
3.6 0.108 3980.00 0.0353 0.01870 -0.00130 0.0718

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.0515 0.00678 0.035700 0.0650
0.1 1.26 0.993 0.0495 0.00741 0.035000 0.0641
0.2 1.58 0.993 0.0495 0.00741 0.035000 0.0641
0.3 2.00 0.993 0.0495 0.00741 0.035000 0.0641
0.4 2.51 0.993 0.0495 0.00741 0.035000 0.0641
0.5 3.16 0.993 0.0495 0.00741 0.035000 0.0641
0.6 3.98 0.993 0.0495 0.00741 0.035000 0.0641
0.7 5.01 0.992 0.0486 0.00733 0.034200 0.0629
0.8 6.31 0.992 0.0486 0.00733 0.034200 0.0629
0.9 7.94 0.992 0.0486 0.00733 0.034200 0.0629
1.0 10.00 0.992 0.0486 0.00733 0.034200 0.0629
1.1 12.60 0.989 0.0480 0.00730 0.033700 0.0623
1.2 15.80 0.986 0.0482 0.00733 0.033800 0.0625
1.3 20.00 0.986 0.0482 0.00733 0.033800 0.0625
1.4 25.10 0.978 0.0486 0.00740 0.034100 0.0631
1.5 31.60 0.972 0.0490 0.00747 0.034400 0.0637
1.6 39.80 0.969 0.0492 0.00749 0.034500 0.0638
1.7 50.10 0.966 0.0493 0.00752 0.034600 0.0641
1.8 63.10 0.958 0.0498 0.00760 0.035000 0.0647
1.9 79.40 0.949 0.0503 0.00768 0.035300 0.0654
2.0 100.00 0.946 0.0495 0.00764 0.034600 0.0645
2.1 126.00 0.916 0.0503 0.00784 0.035000 0.0657
2.2 158.00 0.872 0.0516 0.00823 0.035500 0.0678
2.3 200.00 0.854 0.0514 0.00828 0.035200 0.0677
2.4 251.00 0.800 0.0548 0.00888 0.037400 0.0722
2.5 316.00 0.740 0.0564 0.00936 0.038100 0.0748
2.6 398.00 0.694 0.0546 0.00965 0.035600 0.0735
2.7 501.00 0.613 0.0564 0.01050 0.035700 0.0770
2.8 631.00 0.564 0.0534 0.01060 0.032700 0.0741
2.9 794.00 0.508 0.0537 0.01130 0.031600 0.0758
3.0 1000.00 0.436 0.0581 0.01270 0.033200 0.0831
3.1 1260.00 0.351 0.0672 0.01530 0.037300 0.0971
3.2 1580.00 0.291 0.0595 0.01670 0.026900 0.0922
3.3 2000.00 0.239 0.0584 0.01780 0.023400 0.0934
3.4 2510.00 0.184 0.0403 0.01570 0.009520 0.0710
3.5 3160.00 0.154 0.0335 0.01530 0.003450 0.0636
3.6 3980.00 0.108 0.0370 0.01870 0.000438 0.0736

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.122 0.157 -0.186 0.430
0.1 0.993 1.26 0.129 0.165 -0.194 0.452
0.2 0.993 1.58 0.129 0.165 -0.194 0.452
0.3 0.993 2.00 0.129 0.165 -0.194 0.452
0.4 0.993 2.51 0.129 0.165 -0.194 0.452
0.5 0.993 3.16 0.129 0.165 -0.194 0.452
0.6 0.993 3.98 0.129 0.165 -0.194 0.452
0.7 0.992 5.01 0.129 0.164 -0.192 0.450
0.8 0.992 6.31 0.129 0.164 -0.192 0.450
0.9 0.992 7.94 0.129 0.164 -0.192 0.450
1.0 0.992 10.00 0.129 0.164 -0.192 0.450
1.1 0.989 12.60 0.129 0.163 -0.191 0.449
1.2 0.986 15.80 0.129 0.164 -0.192 0.449
1.3 0.986 20.00 0.129 0.164 -0.192 0.449
1.4 0.978 25.10 0.129 0.165 -0.194 0.451
1.5 0.972 31.60 0.129 0.166 -0.196 0.453
1.6 0.969 39.80 0.129 0.166 -0.196 0.454
1.7 0.966 50.10 0.129 0.166 -0.197 0.454
1.8 0.958 63.10 0.129 0.167 -0.199 0.456
1.9 0.949 79.40 0.129 0.168 -0.201 0.459
2.0 0.946 100.00 0.129 0.168 -0.200 0.457
2.1 0.916 126.00 0.129 0.170 -0.205 0.463
2.2 0.872 158.00 0.129 0.176 -0.216 0.473
2.3 0.854 200.00 0.129 0.176 -0.217 0.474
2.4 0.800 251.00 0.129 0.185 -0.233 0.491
2.5 0.740 316.00 0.129 0.191 -0.246 0.504
2.6 0.694 398.00 0.129 0.196 -0.255 0.512
2.7 0.613 501.00 0.129 0.208 -0.280 0.537
2.8 0.564 631.00 0.129 0.209 -0.281 0.538
2.9 0.508 794.00 0.129 0.219 -0.301 0.558
3.0 0.436 1000.00 0.129 0.241 -0.344 0.601
3.1 0.351 1260.00 0.129 0.281 -0.422 0.679
3.2 0.291 1580.00 0.129 0.303 -0.465 0.723
3.3 0.239 2000.00 0.129 0.322 -0.502 0.760
3.4 0.184 2510.00 0.314 0.280 -0.235 0.863
3.5 0.154 3160.00 0.399 0.271 -0.133 0.931
3.6 0.108 3980.00 0.399 0.326 -0.240 1.040

IgG V1V2 C.1086-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.0515 0.00678 0.03820 0.0648
0.1 0.990 1.26 0.0514 0.00739 0.03690 0.0659
0.2 0.990 1.58 0.0514 0.00739 0.03690 0.0659
0.3 0.990 2.00 0.0514 0.00739 0.03690 0.0659
0.4 0.990 2.51 0.0514 0.00739 0.03690 0.0659
0.5 0.990 3.16 0.0514 0.00739 0.03690 0.0659
0.6 0.990 3.98 0.0514 0.00739 0.03690 0.0659
0.7 0.990 5.01 0.0514 0.00739 0.03690 0.0659
0.8 0.990 6.31 0.0514 0.00739 0.03690 0.0659
0.9 0.990 7.94 0.0514 0.00739 0.03690 0.0659
1.0 0.989 10.00 0.0514 0.00731 0.03710 0.0657
1.1 0.988 12.60 0.0514 0.00723 0.03720 0.0656
1.2 0.982 15.80 0.0514 0.00730 0.03710 0.0657
1.3 0.976 20.00 0.0514 0.00736 0.03700 0.0658
1.4 0.975 25.10 0.0514 0.00728 0.03710 0.0657
1.5 0.956 31.60 0.0514 0.00737 0.03700 0.0659
1.6 0.933 39.80 0.0514 0.00761 0.03650 0.0663
1.7 0.926 50.10 0.0514 0.00760 0.03650 0.0663
1.8 0.903 63.10 0.0514 0.00767 0.03640 0.0664
1.9 0.888 79.40 0.0514 0.00780 0.03610 0.0667
2.0 0.865 100.00 0.0514 0.00794 0.03590 0.0670
2.1 0.817 126.00 0.0514 0.00872 0.03430 0.0685
2.2 0.745 158.00 0.0514 0.00939 0.03300 0.0698
2.3 0.709 200.00 0.0514 0.00976 0.03230 0.0705
2.4 0.655 251.00 0.0514 0.01060 0.03070 0.0721
2.5 0.584 316.00 0.0514 0.01100 0.02980 0.0730
2.6 0.537 398.00 0.0514 0.01080 0.03030 0.0725
2.7 0.454 501.00 0.0514 0.01270 0.02650 0.0764
2.8 0.363 631.00 0.0514 0.01420 0.02350 0.0793
2.9 0.314 794.00 0.0514 0.01430 0.02340 0.0794
3.0 0.270 1000.00 0.0514 0.01680 0.01840 0.0844
3.1 0.205 1260.00 0.0514 0.02010 0.01200 0.0909
3.2 0.166 1580.00 0.0405 0.01650 0.00812 0.0729

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.0515 0.00678 0.03570 0.0650
0.1 1.26 0.990 0.0490 0.00739 0.03450 0.0635
0.2 1.58 0.990 0.0490 0.00739 0.03450 0.0635
0.3 2.00 0.990 0.0490 0.00739 0.03450 0.0635
0.4 2.51 0.990 0.0490 0.00739 0.03450 0.0635
0.5 3.16 0.990 0.0490 0.00739 0.03450 0.0635
0.6 3.98 0.990 0.0490 0.00739 0.03450 0.0635
0.7 5.01 0.990 0.0490 0.00739 0.03450 0.0635
0.8 6.31 0.990 0.0490 0.00739 0.03450 0.0635
0.9 7.94 0.990 0.0490 0.00739 0.03450 0.0635
1.0 10.00 0.989 0.0480 0.00731 0.03370 0.0623
1.1 12.60 0.988 0.0471 0.00723 0.03290 0.0613
1.2 15.80 0.982 0.0475 0.00730 0.03320 0.0618
1.3 20.00 0.976 0.0479 0.00736 0.03350 0.0623
1.4 25.10 0.975 0.0470 0.00728 0.03270 0.0613
1.5 31.60 0.956 0.0476 0.00737 0.03310 0.0620
1.6 39.80 0.933 0.0490 0.00761 0.03410 0.0640
1.7 50.10 0.926 0.0485 0.00760 0.03360 0.0634
1.8 63.10 0.903 0.0484 0.00767 0.03340 0.0634
1.9 79.40 0.888 0.0492 0.00780 0.03390 0.0645
2.0 100.00 0.865 0.0495 0.00794 0.03390 0.0651
2.1 126.00 0.817 0.0542 0.00872 0.03710 0.0712
2.2 158.00 0.745 0.0568 0.00939 0.03840 0.0752
2.3 200.00 0.709 0.0575 0.00976 0.03830 0.0766
2.4 251.00 0.655 0.0612 0.01060 0.04050 0.0819
2.5 316.00 0.584 0.0603 0.01100 0.03880 0.0819
2.6 398.00 0.537 0.0545 0.01080 0.03340 0.0756
2.7 501.00 0.454 0.0623 0.01270 0.03730 0.0872
2.8 631.00 0.363 0.0603 0.01420 0.03240 0.0882
2.9 794.00 0.314 0.0545 0.01430 0.02650 0.0826
3.0 1000.00 0.270 0.0589 0.01680 0.02590 0.0919
3.1 1260.00 0.205 0.0703 0.02010 0.03080 0.1100
3.2 1580.00 0.166 0.0405 0.01650 0.00812 0.0729

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.122 0.157 -0.186 0.430
0.1 0.990 1.26 0.124 0.165 -0.199 0.447
0.2 0.990 1.58 0.124 0.165 -0.199 0.447
0.3 0.990 2.00 0.124 0.165 -0.199 0.447
0.4 0.990 2.51 0.124 0.165 -0.199 0.447
0.5 0.990 3.16 0.124 0.165 -0.199 0.447
0.6 0.990 3.98 0.124 0.165 -0.199 0.447
0.7 0.990 5.01 0.124 0.165 -0.199 0.447
0.8 0.990 6.31 0.124 0.165 -0.199 0.447
0.9 0.990 7.94 0.124 0.165 -0.199 0.447
1.0 0.989 10.00 0.124 0.164 -0.197 0.445
1.1 0.988 12.60 0.124 0.163 -0.195 0.443
1.2 0.982 15.80 0.124 0.164 -0.197 0.445
1.3 0.976 20.00 0.124 0.164 -0.198 0.446
1.4 0.975 25.10 0.124 0.163 -0.197 0.444
1.5 0.956 31.60 0.124 0.165 -0.199 0.447
1.6 0.933 39.80 0.124 0.168 -0.205 0.453
1.7 0.926 50.10 0.124 0.168 -0.205 0.452
1.8 0.903 63.10 0.124 0.168 -0.206 0.454
1.9 0.888 79.40 0.124 0.170 -0.210 0.457
2.0 0.865 100.00 0.124 0.172 -0.214 0.461
2.1 0.817 126.00 0.124 0.183 -0.234 0.482
2.2 0.745 158.00 0.124 0.192 -0.253 0.500
2.3 0.709 200.00 0.124 0.197 -0.263 0.511
2.4 0.655 251.00 0.124 0.209 -0.286 0.533
2.5 0.584 316.00 0.124 0.216 -0.299 0.547
2.6 0.537 398.00 0.124 0.212 -0.292 0.540
2.7 0.454 501.00 0.124 0.242 -0.350 0.597
2.8 0.363 631.00 0.124 0.265 -0.395 0.643
2.9 0.314 794.00 0.124 0.266 -0.397 0.645
3.0 0.270 1000.00 0.124 0.306 -0.476 0.723
3.1 0.205 1260.00 0.124 0.359 -0.580 0.828
3.2 0.166 1580.00 0.310 0.294 -0.266 0.886

IgG V1V2 C.1086-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.0515 0.00678 0.03820 0.0648
0.1 0.974 1.26 0.0514 0.00761 0.03650 0.0663
0.2 0.974 1.58 0.0514 0.00761 0.03650 0.0663
0.3 0.974 2.00 0.0514 0.00761 0.03650 0.0663
0.4 0.974 2.51 0.0514 0.00761 0.03650 0.0663
0.5 0.974 3.16 0.0514 0.00761 0.03650 0.0663
0.6 0.974 3.98 0.0514 0.00761 0.03650 0.0663
0.7 0.974 5.01 0.0514 0.00761 0.03650 0.0663
0.8 0.974 6.31 0.0514 0.00761 0.03650 0.0663
0.9 0.974 7.94 0.0514 0.00761 0.03650 0.0663
1.0 0.974 10.00 0.0514 0.00761 0.03650 0.0663
1.1 0.973 12.60 0.0514 0.00752 0.03670 0.0661
1.2 0.973 15.80 0.0514 0.00752 0.03670 0.0661
1.3 0.973 20.00 0.0514 0.00752 0.03670 0.0661
1.4 0.970 25.10 0.0514 0.00754 0.03660 0.0662
1.5 0.970 31.60 0.0514 0.00754 0.03660 0.0662
1.6 0.970 39.80 0.0514 0.00754 0.03660 0.0662
1.7 0.964 50.10 0.0514 0.00749 0.03670 0.0661
1.8 0.961 63.10 0.0514 0.00753 0.03660 0.0662
1.9 0.961 79.40 0.0514 0.00753 0.03660 0.0662
2.0 0.958 100.00 0.0514 0.00756 0.03660 0.0662
2.1 0.952 126.00 0.0514 0.00761 0.03650 0.0663
2.2 0.949 158.00 0.0514 0.00764 0.03640 0.0664
2.3 0.944 200.00 0.0514 0.00769 0.03630 0.0665
2.4 0.941 251.00 0.0514 0.00772 0.03630 0.0665
2.5 0.920 316.00 0.0514 0.00778 0.03620 0.0666
2.6 0.909 398.00 0.0514 0.00792 0.03590 0.0669
2.7 0.894 501.00 0.0514 0.00799 0.03570 0.0671
2.8 0.859 631.00 0.0514 0.00843 0.03490 0.0679
2.9 0.818 794.00 0.0514 0.00861 0.03450 0.0683
3.0 0.787 1000.00 0.0514 0.00872 0.03430 0.0685
3.1 0.756 1260.00 0.0514 0.00898 0.03380 0.0690
3.2 0.725 1580.00 0.0514 0.00907 0.03360 0.0692
3.3 0.675 2000.00 0.0514 0.00947 0.03280 0.0700
3.4 0.621 2510.00 0.0514 0.00993 0.03190 0.0709
3.5 0.566 3160.00 0.0514 0.01040 0.03100 0.0718
3.6 0.490 3980.00 0.0514 0.01160 0.02870 0.0741
3.7 0.436 5010.00 0.0514 0.01160 0.02870 0.0741
3.8 0.390 6310.00 0.0514 0.01180 0.02820 0.0746
3.9 0.330 7940.00 0.0514 0.01320 0.02550 0.0773
4.0 0.286 10000.00 0.0514 0.01610 0.01980 0.0830
4.1 0.235 12600.00 0.0514 0.01650 0.01900 0.0838
4.2 0.191 15800.00 0.0467 0.01760 0.01220 0.0812
4.3 0.150 20000.00 0.0467 0.02020 0.00711 0.0863

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.0515 0.00678 0.03570 0.0650
0.1 1.26 0.974 0.0509 0.00761 0.03600 0.0658
0.2 1.58 0.974 0.0509 0.00761 0.03600 0.0658
0.3 2.00 0.974 0.0509 0.00761 0.03600 0.0658
0.4 2.51 0.974 0.0509 0.00761 0.03600 0.0658
0.5 3.16 0.974 0.0509 0.00761 0.03600 0.0658
0.6 3.98 0.974 0.0509 0.00761 0.03600 0.0658
0.7 5.01 0.974 0.0509 0.00761 0.03600 0.0658
0.8 6.31 0.974 0.0509 0.00761 0.03600 0.0658
0.9 7.94 0.974 0.0509 0.00761 0.03600 0.0658
1.0 10.00 0.974 0.0509 0.00761 0.03600 0.0658
1.1 12.60 0.973 0.0498 0.00752 0.03510 0.0646
1.2 15.80 0.973 0.0498 0.00752 0.03510 0.0646
1.3 20.00 0.973 0.0498 0.00752 0.03510 0.0646
1.4 25.10 0.970 0.0500 0.00754 0.03520 0.0648
1.5 31.60 0.970 0.0500 0.00754 0.03520 0.0648
1.6 39.80 0.970 0.0500 0.00754 0.03520 0.0648
1.7 50.10 0.964 0.0493 0.00749 0.03460 0.0639
1.8 63.10 0.961 0.0495 0.00753 0.03480 0.0643
1.9 79.40 0.961 0.0495 0.00753 0.03480 0.0643
2.0 100.00 0.958 0.0497 0.00756 0.03490 0.0645
2.1 126.00 0.952 0.0501 0.00761 0.03520 0.0650
2.2 158.00 0.949 0.0503 0.00764 0.03530 0.0653
2.3 200.00 0.944 0.0506 0.00769 0.03550 0.0657
2.4 251.00 0.941 0.0508 0.00772 0.03560 0.0659
2.5 316.00 0.920 0.0506 0.00778 0.03530 0.0658
2.6 398.00 0.909 0.0515 0.00792 0.03600 0.0670
2.7 501.00 0.894 0.0514 0.00799 0.03570 0.0670
2.8 631.00 0.859 0.0542 0.00843 0.03770 0.0707
2.9 794.00 0.818 0.0541 0.00861 0.03720 0.0710
3.0 1000.00 0.787 0.0529 0.00872 0.03580 0.0700
3.1 1260.00 0.756 0.0539 0.00898 0.03630 0.0715
3.2 1580.00 0.725 0.0524 0.00907 0.03460 0.0702
3.3 2000.00 0.675 0.0532 0.00947 0.03460 0.0717
3.4 2510.00 0.621 0.0529 0.00993 0.03340 0.0723
3.5 3160.00 0.566 0.0542 0.01040 0.03380 0.0746
3.6 3980.00 0.490 0.0581 0.01160 0.03540 0.0808
3.7 5010.00 0.436 0.0537 0.01160 0.03100 0.0764
3.8 6310.00 0.390 0.0501 0.01180 0.02690 0.0732
3.9 7940.00 0.330 0.0518 0.01320 0.02590 0.0777
4.0 10000.00 0.286 0.0612 0.01610 0.02970 0.0928
4.1 12600.00 0.235 0.0515 0.01650 0.01910 0.0839
4.2 15800.00 0.191 0.0443 0.01760 0.00982 0.0788
4.3 20000.00 0.150 0.0491 0.02020 0.00953 0.0888

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.122 0.157 -0.186 0.430
0.1 0.974 1.26 0.124 0.168 -0.205 0.453
0.2 0.974 1.58 0.124 0.168 -0.205 0.453
0.3 0.974 2.00 0.124 0.168 -0.205 0.453
0.4 0.974 2.51 0.124 0.168 -0.205 0.453
0.5 0.974 3.16 0.124 0.168 -0.205 0.453
0.6 0.974 3.98 0.124 0.168 -0.205 0.453
0.7 0.974 5.01 0.124 0.168 -0.205 0.453
0.8 0.974 6.31 0.124 0.168 -0.205 0.453
0.9 0.974 7.94 0.124 0.168 -0.205 0.453
1.0 0.974 10.00 0.124 0.168 -0.205 0.453
1.1 0.973 12.60 0.124 0.166 -0.202 0.450
1.2 0.973 15.80 0.124 0.166 -0.202 0.450
1.3 0.973 20.00 0.124 0.166 -0.202 0.450
1.4 0.970 25.10 0.124 0.167 -0.203 0.451
1.5 0.970 31.60 0.124 0.167 -0.203 0.451
1.6 0.970 39.80 0.124 0.167 -0.203 0.451
1.7 0.964 50.10 0.124 0.166 -0.201 0.450
1.8 0.961 63.10 0.124 0.167 -0.203 0.451
1.9 0.961 79.40 0.124 0.167 -0.203 0.451
2.0 0.958 100.00 0.124 0.167 -0.203 0.452
2.1 0.952 126.00 0.124 0.168 -0.205 0.453
2.2 0.949 158.00 0.124 0.168 -0.205 0.454
2.3 0.944 200.00 0.124 0.169 -0.207 0.455
2.4 0.941 251.00 0.124 0.169 -0.207 0.456
2.5 0.920 316.00 0.124 0.170 -0.209 0.457
2.6 0.909 398.00 0.124 0.172 -0.213 0.461
2.7 0.894 501.00 0.124 0.173 -0.214 0.463
2.8 0.859 631.00 0.124 0.179 -0.226 0.474
2.9 0.818 794.00 0.124 0.181 -0.231 0.479
3.0 0.787 1000.00 0.124 0.183 -0.234 0.482
3.1 0.756 1260.00 0.124 0.186 -0.241 0.489
3.2 0.725 1580.00 0.124 0.188 -0.244 0.492
3.3 0.675 2000.00 0.124 0.193 -0.255 0.503
3.4 0.621 2510.00 0.124 0.200 -0.268 0.516
3.5 0.566 3160.00 0.124 0.207 -0.281 0.529
3.6 0.490 3980.00 0.124 0.224 -0.316 0.564
3.7 0.436 5010.00 0.124 0.224 -0.315 0.563
3.8 0.390 6310.00 0.124 0.228 -0.322 0.571
3.9 0.330 7940.00 0.124 0.249 -0.364 0.612
4.0 0.286 10000.00 0.124 0.294 -0.453 0.701
4.1 0.235 12600.00 0.124 0.301 -0.466 0.715
4.2 0.191 15800.00 0.204 0.315 -0.414 0.821
4.3 0.150 20000.00 0.204 0.358 -0.497 0.905

IgG3 V1V2 B.CaseA-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.0515 0.00678 0.03820 0.0648
0.1 0.5320 1.26 0.0496 0.01020 0.02960 0.0697
0.2 0.5230 1.58 0.0493 0.01020 0.02940 0.0692
0.3 0.5060 2.00 0.0493 0.01050 0.02870 0.0700
0.4 0.4910 2.51 0.0487 0.01040 0.02830 0.0691
0.5 0.4840 3.16 0.0469 0.01000 0.02730 0.0665
0.6 0.4610 3.98 0.0469 0.01040 0.02650 0.0673
0.7 0.4510 5.01 0.0455 0.01030 0.02530 0.0656
0.8 0.4420 6.31 0.0451 0.01030 0.02490 0.0652
0.9 0.4330 7.94 0.0451 0.01060 0.02440 0.0658
1.0 0.4270 10.00 0.0451 0.01040 0.02480 0.0654
1.1 0.3980 12.60 0.0451 0.01120 0.02310 0.0671
1.2 0.3890 15.80 0.0451 0.01100 0.02350 0.0666
1.3 0.3670 20.00 0.0451 0.01140 0.02280 0.0674
1.4 0.3420 25.10 0.0451 0.01260 0.02040 0.0697
1.5 0.3350 31.60 0.0436 0.01200 0.02010 0.0671
1.6 0.3190 39.80 0.0436 0.01220 0.01980 0.0675
1.7 0.3050 50.10 0.0436 0.01330 0.01750 0.0698
1.8 0.2740 63.10 0.0436 0.01400 0.01620 0.0710
1.9 0.2430 79.40 0.0436 0.01580 0.01270 0.0746
2.0 0.2340 100.00 0.0436 0.01610 0.01200 0.0752
2.1 0.2190 126.00 0.0436 0.01770 0.00890 0.0783
2.2 0.1910 158.00 0.0436 0.01550 0.01330 0.0739
2.3 0.1680 200.00 0.0436 0.01760 0.00908 0.0782
2.4 0.1510 251.00 0.0436 0.01870 0.00696 0.0803
2.5 0.1140 316.00 0.0436 0.02450 -0.00447 0.0917
2.6 0.1060 398.00 0.0436 0.02840 -0.01200 0.0992
2.7 0.0932 501.00 0.0436 0.06170 -0.07730 0.1650

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.0515 0.00678 3.57e-02 0.0650
0.1 1.26 0.5320 0.0496 0.01020 2.96e-02 0.0697
0.2 1.58 0.5230 0.0485 0.01020 2.86e-02 0.0684
0.3 2.00 0.5060 0.0501 0.01050 2.95e-02 0.0708
0.4 2.51 0.4910 0.0487 0.01040 2.83e-02 0.0691
0.5 3.16 0.4840 0.0460 0.01000 2.64e-02 0.0656
0.6 3.98 0.4610 0.0478 0.01040 2.75e-02 0.0682
0.7 5.01 0.4510 0.0455 0.01030 2.53e-02 0.0656
0.8 6.31 0.4420 0.0445 0.01030 2.43e-02 0.0646
0.9 7.94 0.4330 0.0457 0.01060 2.50e-02 0.0664
1.0 10.00 0.4270 0.0437 0.01040 2.34e-02 0.0641
1.1 12.60 0.3980 0.0464 0.01120 2.44e-02 0.0684
1.2 15.80 0.3890 0.0442 0.01100 2.27e-02 0.0658
1.3 20.00 0.3670 0.0434 0.01140 2.11e-02 0.0657
1.4 25.10 0.3420 0.0477 0.01260 2.31e-02 0.0724
1.5 31.60 0.3350 0.0426 0.01200 1.91e-02 0.0660
1.6 39.80 0.3190 0.0403 0.01220 1.65e-02 0.0642
1.7 50.10 0.3050 0.0440 0.01330 1.79e-02 0.0702
1.8 63.10 0.2740 0.0437 0.01400 1.63e-02 0.0711
1.9 79.40 0.2430 0.0480 0.01580 1.71e-02 0.0790
2.0 100.00 0.2340 0.0469 0.01610 1.53e-02 0.0785
2.1 126.00 0.2190 0.0486 0.01770 1.39e-02 0.0833
2.2 158.00 0.1910 0.0346 0.01550 4.31e-03 0.0649
2.3 200.00 0.1680 0.0391 0.01760 4.54e-03 0.0736
2.4 251.00 0.1510 0.0367 0.01870 4.15e-05 0.0734
2.5 316.00 0.1140 0.0398 0.02450 -8.27e-03 0.0879
2.6 398.00 0.1060 0.0438 0.02840 -1.18e-02 0.0994
2.7 501.00 0.0932 0.0758 0.06170 -4.51e-02 0.1970

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.122 0.157 -0.186 0.430
0.1 0.5320 1.26 0.154 0.202 -0.242 0.550
0.2 0.5230 1.58 0.160 0.201 -0.234 0.554
0.3 0.5060 2.00 0.160 0.206 -0.245 0.565
0.4 0.4910 2.51 0.170 0.204 -0.229 0.570
0.5 0.4840 3.16 0.201 0.196 -0.184 0.585
0.6 0.4610 3.98 0.201 0.202 -0.196 0.597
0.7 0.4510 5.01 0.225 0.199 -0.165 0.615
0.8 0.4420 6.31 0.232 0.199 -0.157 0.621
0.9 0.4330 7.94 0.232 0.203 -0.166 0.629
1.0 0.4270 10.00 0.232 0.200 -0.160 0.623
1.1 0.3980 12.60 0.232 0.213 -0.186 0.649
1.2 0.3890 15.80 0.232 0.209 -0.178 0.642
1.3 0.3670 20.00 0.232 0.215 -0.190 0.654
1.4 0.3420 25.10 0.232 0.234 -0.226 0.690
1.5 0.3350 31.60 0.257 0.223 -0.181 0.694
1.6 0.3190 39.80 0.257 0.226 -0.186 0.700
1.7 0.3050 50.10 0.257 0.245 -0.223 0.736
1.8 0.2740 63.10 0.257 0.255 -0.243 0.756
1.9 0.2430 79.40 0.257 0.284 -0.300 0.813
2.0 0.2340 100.00 0.257 0.289 -0.310 0.824
2.1 0.2190 126.00 0.257 0.315 -0.361 0.874
2.2 0.1910 158.00 0.257 0.279 -0.289 0.803
2.3 0.1680 200.00 0.257 0.314 -0.358 0.871
2.4 0.1510 251.00 0.257 0.331 -0.393 0.906
2.5 0.1140 316.00 0.257 0.428 -0.582 1.100
2.6 0.1060 398.00 0.257 0.492 -0.707 1.220
2.7 0.0932 501.00 0.257 1.060 -1.810 2.330

IgG3 V1V2 AE.A244-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.0535 0.00678 0.04020 0.0668
0.1 0.9160 1.26 0.0535 0.00786 0.03810 0.0689
0.2 0.9110 1.58 0.0535 0.00789 0.03810 0.0690
0.3 0.9020 2.00 0.0535 0.00798 0.03790 0.0692
0.4 0.8940 2.51 0.0535 0.00810 0.03770 0.0694
0.5 0.8790 3.16 0.0535 0.00813 0.03760 0.0694
0.6 0.8580 3.98 0.0535 0.00813 0.03760 0.0695
0.7 0.8420 5.01 0.0535 0.00805 0.03770 0.0693
0.8 0.8280 6.31 0.0535 0.00822 0.03740 0.0696
0.9 0.7940 7.94 0.0535 0.00866 0.03650 0.0705
1.0 0.7490 10.00 0.0535 0.00882 0.03620 0.0708
1.1 0.7100 12.60 0.0535 0.00886 0.03620 0.0709
1.2 0.6870 15.80 0.0535 0.00912 0.03560 0.0714
1.3 0.6680 20.00 0.0535 0.00942 0.03510 0.0720
1.4 0.6080 25.10 0.0535 0.00998 0.03400 0.0731
1.5 0.5860 31.60 0.0535 0.01020 0.03360 0.0735
1.6 0.5500 39.80 0.0535 0.01020 0.03350 0.0736
1.7 0.5220 50.10 0.0535 0.01040 0.03320 0.0738
1.8 0.4730 63.10 0.0535 0.01130 0.03130 0.0757
1.9 0.4310 79.40 0.0535 0.01150 0.03110 0.0760
2.0 0.4060 100.00 0.0535 0.01190 0.03010 0.0769
2.1 0.3560 126.00 0.0535 0.01400 0.02600 0.0810
2.2 0.3050 158.00 0.0535 0.01550 0.02310 0.0839
2.3 0.2650 200.00 0.0535 0.01610 0.02190 0.0851
2.4 0.2450 251.00 0.0395 0.01340 0.01330 0.0657
2.5 0.2140 316.00 0.0395 0.01510 0.00993 0.0690
2.6 0.1880 398.00 0.0395 0.01590 0.00841 0.0706
2.7 0.1690 501.00 0.0367 0.01650 0.00439 0.0691
2.8 0.1350 631.00 0.0317 0.01490 0.00245 0.0609
2.9 0.1160 794.00 0.0315 0.01550 0.00111 0.0619
3.0 0.0861 1000.00 0.0315 0.02130 -0.01010 0.0732

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.0515 0.00678 0.03570 0.0650
0.1 1.26 0.9160 0.0516 0.00786 0.03620 0.0670
0.2 1.58 0.9110 0.0518 0.00789 0.03640 0.0673
0.3 2.00 0.9020 0.0524 0.00798 0.03670 0.0680
0.4 2.51 0.8940 0.0532 0.00810 0.03730 0.0690
0.5 3.16 0.8790 0.0528 0.00813 0.03690 0.0687
0.6 3.98 0.8580 0.0518 0.00813 0.03590 0.0677
0.7 5.01 0.8420 0.0502 0.00805 0.03440 0.0660
0.8 6.31 0.8280 0.0513 0.00822 0.03520 0.0674
0.9 7.94 0.7940 0.0539 0.00866 0.03700 0.0709
1.0 10.00 0.7490 0.0531 0.00882 0.03580 0.0703
1.1 12.60 0.7100 0.0513 0.00886 0.03390 0.0686
1.2 15.80 0.6870 0.0520 0.00912 0.03410 0.0699
1.3 20.00 0.6680 0.0536 0.00942 0.03510 0.0720
1.4 25.10 0.6080 0.0552 0.00998 0.03570 0.0748
1.5 31.60 0.5860 0.0564 0.01020 0.03640 0.0763
1.6 39.80 0.5500 0.0540 0.01020 0.03400 0.0740
1.7 50.10 0.5220 0.0522 0.01040 0.03190 0.0725
1.8 63.10 0.4730 0.0557 0.01130 0.03350 0.0779
1.9 79.40 0.4310 0.0523 0.01150 0.02980 0.0747
2.0 100.00 0.4060 0.0529 0.01190 0.02950 0.0763
2.1 126.00 0.3560 0.0609 0.01400 0.03340 0.0883
2.2 158.00 0.3050 0.0636 0.01550 0.03330 0.0940
2.3 200.00 0.2650 0.0611 0.01610 0.02950 0.0928
2.4 251.00 0.2450 0.0395 0.01340 0.01330 0.0657
2.5 316.00 0.2140 0.0403 0.01510 0.01070 0.0698
2.6 398.00 0.1880 0.0399 0.01590 0.00878 0.0709
2.7 501.00 0.1690 0.0367 0.01650 0.00439 0.0691
2.8 631.00 0.1350 0.0317 0.01490 0.00245 0.0609
2.9 794.00 0.1160 0.0292 0.01550 -0.00119 0.0596
3.0 1000.00 0.0861 0.0338 0.02130 -0.00784 0.0755

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.0879 0.160 -0.2260 0.402
0.1 0.9160 1.26 0.0879 0.174 -0.2530 0.428
0.2 0.9110 1.58 0.0879 0.174 -0.2530 0.429
0.3 0.9020 2.00 0.0879 0.175 -0.2560 0.432
0.4 0.8940 2.51 0.0879 0.177 -0.2590 0.435
0.5 0.8790 3.16 0.0879 0.177 -0.2600 0.435
0.6 0.8580 3.98 0.0879 0.177 -0.2600 0.436
0.7 0.8420 5.01 0.0879 0.176 -0.2580 0.433
0.8 0.8280 6.31 0.0879 0.179 -0.2620 0.438
0.9 0.7940 7.94 0.0879 0.185 -0.2740 0.450
1.0 0.7490 10.00 0.0879 0.187 -0.2780 0.454
1.1 0.7100 12.60 0.0879 0.187 -0.2790 0.455
1.2 0.6870 15.80 0.0879 0.191 -0.2860 0.462
1.3 0.6680 20.00 0.0879 0.195 -0.2940 0.470
1.4 0.6080 25.10 0.0879 0.203 -0.3100 0.486
1.5 0.5860 31.60 0.0879 0.206 -0.3160 0.492
1.6 0.5500 39.80 0.0879 0.206 -0.3170 0.492
1.7 0.5220 50.10 0.0879 0.208 -0.3210 0.497
1.8 0.4730 63.10 0.0879 0.223 -0.3480 0.524
1.9 0.4310 79.40 0.0879 0.225 -0.3520 0.528
2.0 0.4060 100.00 0.0879 0.232 -0.3660 0.542
2.1 0.3560 126.00 0.0879 0.263 -0.4280 0.604
2.2 0.3050 158.00 0.0879 0.286 -0.4730 0.649
2.3 0.2650 200.00 0.0879 0.296 -0.4930 0.669
2.4 0.2450 251.00 0.3270 0.242 -0.1470 0.801
2.5 0.2140 316.00 0.3270 0.270 -0.2010 0.856
2.6 0.1880 398.00 0.3270 0.282 -0.2260 0.880
2.7 0.1690 501.00 0.3740 0.291 -0.1970 0.945
2.8 0.1350 631.00 0.4600 0.263 -0.0549 0.975
2.9 0.1160 794.00 0.4630 0.272 -0.0707 0.997
3.0 0.0861 1000.00 0.4630 0.368 -0.2580 1.180

IgG3 V1V2 C.1086-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.0528 0.00678 0.03950 0.0661
0.1 0.8980 1.26 0.0528 0.00811 0.03690 0.0687
0.2 0.8850 1.58 0.0528 0.00807 0.03700 0.0686
0.3 0.8850 2.00 0.0528 0.00807 0.03700 0.0686
0.4 0.8720 2.51 0.0528 0.00820 0.03680 0.0689
0.5 0.8640 3.16 0.0528 0.00823 0.03670 0.0689
0.6 0.8560 3.98 0.0528 0.00827 0.03660 0.0690
0.7 0.8380 5.01 0.0528 0.00842 0.03630 0.0693
0.8 0.8020 6.31 0.0528 0.00839 0.03640 0.0693
0.9 0.7540 7.94 0.0528 0.00872 0.03570 0.0699
1.0 0.7200 10.00 0.0528 0.00914 0.03490 0.0707
1.1 0.6760 12.60 0.0528 0.00952 0.03420 0.0715
1.2 0.6470 15.80 0.0528 0.00963 0.03390 0.0717
1.3 0.6030 20.00 0.0527 0.00976 0.03360 0.0719
1.4 0.5570 25.10 0.0526 0.00995 0.03310 0.0721
1.5 0.5130 31.60 0.0526 0.01000 0.03300 0.0722
1.6 0.4770 39.80 0.0526 0.01060 0.03190 0.0733
1.7 0.4350 50.10 0.0526 0.01110 0.03090 0.0742
1.8 0.3780 63.10 0.0526 0.01290 0.02740 0.0778
1.9 0.3400 79.40 0.0526 0.01340 0.02640 0.0788
2.0 0.3240 100.00 0.0526 0.01370 0.02570 0.0794
2.1 0.3050 126.00 0.0526 0.01380 0.02560 0.0796
2.2 0.2600 158.00 0.0526 0.01560 0.02190 0.0832
2.3 0.2110 200.00 0.0467 0.01580 0.01560 0.0777
2.4 0.1690 251.00 0.0398 0.01430 0.01180 0.0677
2.5 0.1350 316.00 0.0398 0.01560 0.00927 0.0703
2.6 0.0995 398.00 0.0398 0.01940 0.00175 0.0778
2.7 0.0915 501.00 0.0398 0.02130 -0.00196 0.0815

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.0515 0.00678 0.03570 0.0650
0.1 1.26 0.8980 0.0531 0.00811 0.03720 0.0690
0.2 1.58 0.8850 0.0518 0.00807 0.03600 0.0676
0.3 2.00 0.8850 0.0518 0.00807 0.03600 0.0676
0.4 2.51 0.8720 0.0526 0.00820 0.03650 0.0687
0.5 3.16 0.8640 0.0529 0.00823 0.03670 0.0690
0.6 3.98 0.8560 0.0532 0.00827 0.03700 0.0694
0.7 5.01 0.8380 0.0535 0.00842 0.03700 0.0701
0.8 6.31 0.8020 0.0511 0.00839 0.03460 0.0675
0.9 7.94 0.7540 0.0523 0.00872 0.03520 0.0693
1.0 10.00 0.7200 0.0540 0.00914 0.03610 0.0720
1.1 12.60 0.6760 0.0552 0.00952 0.03660 0.0739
1.2 15.80 0.6470 0.0543 0.00963 0.03540 0.0732
1.3 20.00 0.6030 0.0527 0.00976 0.03360 0.0719
1.4 25.10 0.5570 0.0498 0.00995 0.03030 0.0693
1.5 31.60 0.5130 0.0486 0.01000 0.02900 0.0683
1.6 39.80 0.4770 0.0500 0.01060 0.02930 0.0708
1.7 50.10 0.4350 0.0503 0.01110 0.02870 0.0720
1.8 63.10 0.3780 0.0583 0.01290 0.03310 0.0835
1.9 79.40 0.3400 0.0558 0.01340 0.02960 0.0820
2.0 100.00 0.3240 0.0562 0.01370 0.02940 0.0830
2.1 126.00 0.3050 0.0518 0.01380 0.02480 0.0789
2.2 158.00 0.2600 0.0546 0.01560 0.02390 0.0852
2.3 200.00 0.2110 0.0467 0.01580 0.01560 0.0777
2.4 251.00 0.1690 0.0363 0.01430 0.00834 0.0643
2.5 316.00 0.1350 0.0353 0.01560 0.00479 0.0658
2.6 398.00 0.0995 0.0418 0.01940 0.00380 0.0798
2.7 501.00 0.0915 0.0457 0.02130 0.00396 0.0874

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.100 0.159 -0.212 0.412
0.1 0.8980 1.26 0.100 0.176 -0.245 0.445
0.2 0.8850 1.58 0.100 0.176 -0.244 0.444
0.3 0.8850 2.00 0.100 0.176 -0.244 0.444
0.4 0.8720 2.51 0.100 0.177 -0.248 0.448
0.5 0.8640 3.16 0.100 0.178 -0.249 0.448
0.6 0.8560 3.98 0.100 0.178 -0.250 0.450
0.7 0.8380 5.01 0.100 0.180 -0.254 0.454
0.8 0.8020 6.31 0.100 0.180 -0.253 0.453
0.9 0.7540 7.94 0.100 0.184 -0.262 0.461
1.0 0.7200 10.00 0.100 0.190 -0.273 0.473
1.1 0.6760 12.60 0.100 0.196 -0.283 0.483
1.2 0.6470 15.80 0.100 0.197 -0.286 0.486
1.3 0.6030 20.00 0.101 0.199 -0.288 0.491
1.4 0.5570 25.10 0.104 0.201 -0.291 0.499
1.5 0.5130 31.60 0.104 0.202 -0.293 0.501
1.6 0.4770 39.80 0.104 0.210 -0.309 0.516
1.7 0.4350 50.10 0.104 0.218 -0.322 0.530
1.8 0.3780 63.10 0.104 0.245 -0.376 0.583
1.9 0.3400 79.40 0.104 0.252 -0.391 0.598
2.0 0.3240 100.00 0.104 0.257 -0.401 0.609
2.1 0.3050 126.00 0.104 0.259 -0.404 0.611
2.2 0.2600 158.00 0.104 0.288 -0.460 0.668
2.3 0.2110 200.00 0.204 0.287 -0.358 0.766
2.4 0.1690 251.00 0.322 0.257 -0.181 0.825
2.5 0.1350 316.00 0.322 0.278 -0.222 0.867
2.6 0.0995 398.00 0.322 0.341 -0.346 0.990
2.7 0.0915 501.00 0.322 0.372 -0.407 1.050

IgG3 V1V2 C.1086-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.0515 0.00678 0.038200 0.0648
0.1 0.8460 1.26 0.0483 0.00778 0.033100 0.0636
0.2 0.8440 1.58 0.0483 0.00782 0.033000 0.0636
0.3 0.8440 2.00 0.0483 0.00782 0.033000 0.0636
0.4 0.8380 2.51 0.0483 0.00783 0.033000 0.0637
0.5 0.8350 3.16 0.0483 0.00789 0.032900 0.0638
0.6 0.8280 3.98 0.0483 0.00777 0.033100 0.0635
0.7 0.8200 5.01 0.0483 0.00780 0.033000 0.0636
0.8 0.8030 6.31 0.0483 0.00788 0.032900 0.0638
0.9 0.7830 7.94 0.0483 0.00812 0.032400 0.0642
1.0 0.7750 10.00 0.0483 0.00818 0.032300 0.0643
1.1 0.7610 12.60 0.0483 0.00835 0.031900 0.0647
1.2 0.7430 15.80 0.0483 0.00826 0.032100 0.0645
1.3 0.7250 20.00 0.0483 0.00829 0.032100 0.0646
1.4 0.7020 25.10 0.0483 0.00850 0.031600 0.0650
1.5 0.6710 31.60 0.0483 0.00848 0.031700 0.0649
1.6 0.6690 39.80 0.0483 0.00852 0.031600 0.0650
1.7 0.6400 50.10 0.0483 0.00886 0.030900 0.0657
1.8 0.6190 63.10 0.0483 0.00912 0.030400 0.0662
1.9 0.5880 79.40 0.0483 0.00956 0.029600 0.0671
2.0 0.5710 100.00 0.0483 0.00942 0.029800 0.0668
2.1 0.5480 126.00 0.0483 0.00981 0.029100 0.0675
2.2 0.4890 158.00 0.0483 0.01020 0.028400 0.0682
2.3 0.4610 200.00 0.0483 0.01080 0.027100 0.0695
2.4 0.4200 251.00 0.0483 0.01180 0.025200 0.0714
2.5 0.3670 316.00 0.0483 0.01310 0.022700 0.0739
2.6 0.3540 398.00 0.0483 0.01300 0.022900 0.0738
2.7 0.2920 501.00 0.0483 0.01470 0.019500 0.0771
2.8 0.2620 631.00 0.0483 0.01700 0.015100 0.0816
2.9 0.2270 794.00 0.0483 0.01670 0.015500 0.0811
3.0 0.1980 1000.00 0.0481 0.01810 0.012600 0.0837
3.1 0.1810 1260.00 0.0481 0.01880 0.011300 0.0849
3.2 0.1470 1580.00 0.0481 0.02040 0.008050 0.0882
3.3 0.1420 2000.00 0.0481 0.02120 0.006610 0.0897
3.4 0.0954 2510.00 0.0481 0.05340 -0.056600 0.1530
3.5 0.0944 3160.00 0.0341 0.01730 0.000118 0.0680
3.6 0.0741 3980.00 0.0341 0.02090 -0.006910 0.0750

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.0515 0.00678 0.03570 0.0650
0.1 1.26 0.8460 0.0469 0.00778 0.03170 0.0622
0.2 1.58 0.8440 0.0471 0.00782 0.03180 0.0625
0.3 2.00 0.8440 0.0471 0.00782 0.03180 0.0625
0.4 2.51 0.8380 0.0472 0.00783 0.03190 0.0626
0.5 3.16 0.8350 0.0476 0.00789 0.03210 0.0630
0.6 3.98 0.8280 0.0457 0.00777 0.03050 0.0610
0.7 5.01 0.8200 0.0459 0.00780 0.03070 0.0612
0.8 6.31 0.8030 0.0459 0.00788 0.03050 0.0614
0.9 7.94 0.7830 0.0473 0.00812 0.03140 0.0632
1.0 10.00 0.7750 0.0476 0.00818 0.03160 0.0636
1.1 12.60 0.7610 0.0485 0.00835 0.03220 0.0649
1.2 15.80 0.7430 0.0467 0.00826 0.03050 0.0629
1.3 20.00 0.7250 0.0463 0.00829 0.03010 0.0626
1.4 25.10 0.7020 0.0475 0.00850 0.03080 0.0641
1.5 31.60 0.6710 0.0453 0.00848 0.02870 0.0619
1.6 39.80 0.6690 0.0455 0.00852 0.02880 0.0622
1.7 50.10 0.6400 0.0466 0.00886 0.02920 0.0639
1.8 63.10 0.6190 0.0476 0.00912 0.02980 0.0655
1.9 79.40 0.5880 0.0500 0.00956 0.03120 0.0687
2.0 100.00 0.5710 0.0470 0.00942 0.02850 0.0654
2.1 126.00 0.5480 0.0489 0.00981 0.02970 0.0681
2.2 158.00 0.4890 0.0470 0.01020 0.02710 0.0669
2.3 200.00 0.4610 0.0497 0.01080 0.02850 0.0708
2.4 251.00 0.4200 0.0529 0.01180 0.02970 0.0760
2.5 316.00 0.3670 0.0567 0.01310 0.03110 0.0823
2.6 398.00 0.3540 0.0535 0.01300 0.02800 0.0789
2.7 501.00 0.2920 0.0525 0.01470 0.02380 0.0813
2.8 631.00 0.2620 0.0598 0.01700 0.02660 0.0931
2.9 794.00 0.2270 0.0550 0.01670 0.02220 0.0877
3.0 1000.00 0.1980 0.0481 0.01810 0.01250 0.0837
3.1 1260.00 0.1810 0.0453 0.01880 0.00852 0.0821
3.2 1580.00 0.1470 0.0428 0.02040 0.00269 0.0828
3.3 2000.00 0.1420 0.0443 0.02120 0.00274 0.0858
3.4 2510.00 0.0954 0.0830 0.05340 -0.02170 0.1880
3.5 3160.00 0.0944 0.0318 0.01730 -0.00211 0.0658
3.6 3980.00 0.0741 0.0363 0.02090 -0.00467 0.0773

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.122 0.157 -0.186 0.430
0.1 0.8460 1.26 0.177 0.166 -0.149 0.502
0.2 0.8440 1.58 0.177 0.167 -0.150 0.503
0.3 0.8440 2.00 0.177 0.167 -0.150 0.503
0.4 0.8380 2.51 0.177 0.167 -0.150 0.504
0.5 0.8350 3.16 0.177 0.167 -0.151 0.505
0.6 0.8280 3.98 0.177 0.166 -0.148 0.502
0.7 0.8200 5.01 0.177 0.166 -0.149 0.503
0.8 0.8030 6.31 0.177 0.167 -0.151 0.505
0.9 0.7830 7.94 0.177 0.171 -0.158 0.511
1.0 0.7750 10.00 0.177 0.171 -0.159 0.513
1.1 0.7610 12.60 0.177 0.174 -0.164 0.518
1.2 0.7430 15.80 0.177 0.173 -0.161 0.515
1.3 0.7250 20.00 0.177 0.173 -0.162 0.516
1.4 0.7020 25.10 0.177 0.176 -0.168 0.522
1.5 0.6710 31.60 0.177 0.176 -0.168 0.521
1.6 0.6690 39.80 0.177 0.176 -0.169 0.522
1.7 0.6400 50.10 0.177 0.181 -0.178 0.532
1.8 0.6190 63.10 0.177 0.185 -0.185 0.539
1.9 0.5880 79.40 0.177 0.191 -0.198 0.552
2.0 0.5710 100.00 0.177 0.189 -0.194 0.548
2.1 0.5480 126.00 0.177 0.195 -0.205 0.558
2.2 0.4890 158.00 0.177 0.200 -0.215 0.569
2.3 0.4610 200.00 0.177 0.209 -0.234 0.587
2.4 0.4200 251.00 0.177 0.225 -0.263 0.617
2.5 0.3670 316.00 0.177 0.244 -0.302 0.656
2.6 0.3540 398.00 0.177 0.243 -0.299 0.653
2.7 0.2920 501.00 0.177 0.269 -0.351 0.705
2.8 0.2620 631.00 0.177 0.306 -0.423 0.776
2.9 0.2270 794.00 0.177 0.302 -0.415 0.768
3.0 0.1980 1000.00 0.180 0.325 -0.457 0.816
3.1 0.1810 1260.00 0.180 0.335 -0.477 0.837
3.2 0.1470 1580.00 0.180 0.362 -0.531 0.890
3.3 0.1420 2000.00 0.180 0.375 -0.554 0.914
3.4 0.0954 2510.00 0.180 0.916 -1.620 1.970
3.5 0.0944 3160.00 0.419 0.304 -0.175 1.010
3.6 0.0741 3980.00 0.419 0.363 -0.292 1.130

HVTN 702

  • Adjustment covariates: AGELE25, RSCORCAT
  • Event time variable: HIV6.5_24FU
  • Event type variable: HIV6.5_24
  • Weight variable: SAMPWT
  • Reference timepoint: 552 days
  • All learners: GLM

IgG V1V2 B.CaseA-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.136 0.0122 0.11200 0.160
0.1 0.6080 1.26 0.136 0.0309 0.07560 0.197
0.2 0.6080 1.58 0.136 0.0309 0.07560 0.197
0.3 0.6080 2.00 0.136 0.0309 0.07560 0.197
0.4 0.5870 2.51 0.136 0.0331 0.07150 0.201
0.5 0.5870 3.16 0.136 0.0331 0.07150 0.201
0.6 0.5870 3.98 0.136 0.0331 0.07150 0.201
0.7 0.5870 5.01 0.136 0.0331 0.07150 0.201
0.8 0.5870 6.31 0.136 0.0331 0.07150 0.201
0.9 0.5460 7.94 0.136 0.0312 0.07520 0.197
1.0 0.5460 10.00 0.136 0.0312 0.07520 0.197
1.1 0.5460 12.60 0.136 0.0312 0.07520 0.197
1.2 0.5460 15.80 0.136 0.0312 0.07520 0.197
1.3 0.5100 20.00 0.136 0.0313 0.07500 0.198
1.4 0.4850 25.10 0.136 0.0305 0.07650 0.196
1.5 0.4840 31.60 0.136 0.0302 0.07710 0.195
1.6 0.4820 39.80 0.136 0.0299 0.07770 0.195
1.7 0.4800 50.10 0.136 0.0295 0.07840 0.194
1.8 0.4560 63.10 0.136 0.0291 0.07920 0.193
1.9 0.4380 79.40 0.136 0.0300 0.07740 0.195
2.0 0.4120 100.00 0.136 0.0317 0.07420 0.198
2.1 0.3840 126.00 0.136 0.0348 0.06810 0.204
2.2 0.3580 158.00 0.136 0.0399 0.05810 0.215
2.3 0.3400 200.00 0.136 0.0373 0.06320 0.209
2.4 0.3080 251.00 0.136 0.0357 0.06630 0.206
2.5 0.3080 316.00 0.136 0.0357 0.06630 0.206
2.6 0.2700 398.00 0.136 0.0350 0.06760 0.205
2.7 0.2040 501.00 0.136 0.0423 0.05330 0.219
2.8 0.1480 631.00 0.136 0.0689 0.00121 0.271
2.9 0.1310 794.00 0.136 0.0800 -0.02040 0.293
3.0 0.1300 1000.00 0.136 0.0786 -0.01780 0.290
3.1 0.0964 1260.00 0.136 0.1030 -0.06500 0.338
3.2 0.0704 1580.00 0.136 0.1540 -0.16500 0.437
3.3 0.0635 2000.00 0.136 0.1490 -0.15500 0.428
3.4 0.0618 2510.00 0.136 0.1560 -0.16900 0.442
3.5 0.0512 3160.00 0.136 0.1600 -0.17600 0.449

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.0952 0.0122 0.0636 0.129
0.1 1.26 0.6080 0.1300 0.0309 0.0692 0.191
0.2 1.58 0.6080 0.1300 0.0309 0.0692 0.191
0.3 2.00 0.6080 0.1300 0.0309 0.0692 0.191
0.4 2.51 0.5870 0.1360 0.0331 0.0712 0.201
0.5 3.16 0.5870 0.1360 0.0331 0.0712 0.201
0.6 3.98 0.5870 0.1360 0.0331 0.0712 0.201
0.7 5.01 0.5870 0.1360 0.0331 0.0712 0.201
0.8 6.31 0.5870 0.1360 0.0331 0.0712 0.201
0.9 7.94 0.5460 0.1330 0.0312 0.0722 0.194
1.0 10.00 0.5460 0.1330 0.0312 0.0722 0.194
1.1 12.60 0.5460 0.1330 0.0312 0.0722 0.194
1.2 15.80 0.5460 0.1330 0.0312 0.0722 0.194
1.3 20.00 0.5100 0.1360 0.0313 0.0751 0.198
1.4 25.10 0.4850 0.1340 0.0305 0.0747 0.194
1.5 31.60 0.4840 0.1320 0.0302 0.0726 0.191
1.6 39.80 0.4820 0.1290 0.0299 0.0707 0.188
1.7 50.10 0.4800 0.1270 0.0295 0.0687 0.184
1.8 63.10 0.4560 0.1240 0.0291 0.0670 0.181
1.9 79.40 0.4380 0.1240 0.0300 0.0650 0.183
2.0 100.00 0.4120 0.1240 0.0317 0.0618 0.186
2.1 126.00 0.3840 0.1270 0.0348 0.0589 0.195
2.2 158.00 0.3580 0.1360 0.0399 0.0580 0.214
2.3 200.00 0.3400 0.1190 0.0373 0.0456 0.192
2.4 251.00 0.3080 0.1090 0.0357 0.0391 0.179
2.5 316.00 0.3080 0.1090 0.0357 0.0391 0.179
2.6 398.00 0.2700 0.1020 0.0350 0.0329 0.170
2.7 501.00 0.2040 0.1130 0.0423 0.0305 0.196
2.8 631.00 0.1480 0.1900 0.0689 0.0546 0.325
2.9 794.00 0.1310 0.2140 0.0800 0.0572 0.371
3.0 1000.00 0.1300 0.2020 0.0786 0.0475 0.356
3.1 1260.00 0.0964 0.4160 0.1030 0.2150 0.617
3.2 1580.00 0.0704 0.6290 0.1540 0.3280 0.930
3.3 2000.00 0.0635 0.5310 0.1490 0.2400 0.823
3.4 2510.00 0.0618 0.5070 0.1560 0.2010 0.813
3.5 3160.00 0.0512 0.4990 0.1600 0.1860 0.811

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 -0.656 0.276 -1.20 -0.114
0.1 0.6080 1.26 -0.656 0.442 -1.52 0.212
0.2 0.6080 1.58 -0.656 0.442 -1.52 0.212
0.3 0.6080 2.00 -0.656 0.442 -1.52 0.212
0.4 0.5870 2.51 -0.656 0.464 -1.57 0.255
0.5 0.5870 3.16 -0.656 0.464 -1.57 0.255
0.6 0.5870 3.98 -0.656 0.464 -1.57 0.255
0.7 0.5870 5.01 -0.656 0.464 -1.57 0.255
0.8 0.5870 6.31 -0.656 0.464 -1.57 0.255
0.9 0.5460 7.94 -0.656 0.445 -1.53 0.217
1.0 0.5460 10.00 -0.656 0.445 -1.53 0.217
1.1 0.5460 12.60 -0.656 0.445 -1.53 0.217
1.2 0.5460 15.80 -0.656 0.445 -1.53 0.217
1.3 0.5100 20.00 -0.656 0.446 -1.53 0.218
1.4 0.4850 25.10 -0.656 0.438 -1.51 0.203
1.5 0.4840 31.60 -0.656 0.435 -1.51 0.197
1.6 0.4820 39.80 -0.656 0.432 -1.50 0.190
1.7 0.4800 50.10 -0.656 0.428 -1.49 0.183
1.8 0.4560 63.10 -0.656 0.424 -1.49 0.175
1.9 0.4380 79.40 -0.656 0.433 -1.50 0.193
2.0 0.4120 100.00 -0.656 0.450 -1.54 0.227
2.1 0.3840 126.00 -0.656 0.483 -1.60 0.290
2.2 0.3580 158.00 -0.656 0.538 -1.71 0.399
2.3 0.3400 200.00 -0.656 0.509 -1.65 0.343
2.4 0.3080 251.00 -0.656 0.493 -1.62 0.310
2.5 0.3080 316.00 -0.656 0.493 -1.62 0.310
2.6 0.2700 398.00 -0.656 0.485 -1.61 0.296
2.7 0.2040 501.00 -0.656 0.565 -1.76 0.451
2.8 0.1480 631.00 -0.656 0.869 -2.36 1.050
2.9 0.1310 794.00 -0.656 0.999 -2.61 1.300
3.0 0.1300 1000.00 -0.656 0.983 -2.58 1.270
3.1 0.0964 1260.00 -0.656 1.270 -3.14 1.830
3.2 0.0704 1580.00 -0.656 1.880 -4.34 3.030
3.3 0.0635 2000.00 -0.656 1.820 -4.23 2.920
3.4 0.0618 2510.00 -0.656 1.910 -4.40 3.090
3.5 0.0512 3160.00 -0.656 1.950 -4.48 3.170

IgG V1V2 AE.A244-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.0997 0.0122 0.07580 0.124
0.1 0.9580 1.26 0.0997 0.0165 0.06730 0.132
0.2 0.9580 1.58 0.0997 0.0165 0.06730 0.132
0.3 0.9580 2.00 0.0997 0.0165 0.06730 0.132
0.4 0.9580 2.51 0.0997 0.0165 0.06730 0.132
0.5 0.9580 3.16 0.0997 0.0165 0.06730 0.132
0.6 0.9580 3.98 0.0997 0.0165 0.06730 0.132
0.7 0.9580 5.01 0.0997 0.0165 0.06730 0.132
0.8 0.9580 6.31 0.0997 0.0165 0.06730 0.132
0.9 0.9580 7.94 0.0997 0.0165 0.06730 0.132
1.0 0.9580 10.00 0.0997 0.0165 0.06730 0.132
1.1 0.9560 12.60 0.0997 0.0166 0.06710 0.132
1.2 0.9560 15.80 0.0997 0.0166 0.06710 0.132
1.3 0.9540 20.00 0.0997 0.0164 0.06760 0.132
1.4 0.9400 25.10 0.0997 0.0168 0.06670 0.133
1.5 0.9400 31.60 0.0997 0.0168 0.06670 0.133
1.6 0.9400 39.80 0.0997 0.0168 0.06670 0.133
1.7 0.9380 50.10 0.0997 0.0166 0.06710 0.132
1.8 0.9380 63.10 0.0997 0.0166 0.06710 0.132
1.9 0.9150 79.40 0.0997 0.0173 0.06580 0.134
2.0 0.9150 100.00 0.0997 0.0173 0.06580 0.134
2.1 0.9140 126.00 0.0997 0.0171 0.06610 0.133
2.2 0.8980 158.00 0.0997 0.0167 0.06700 0.132
2.3 0.8860 200.00 0.0997 0.0170 0.06630 0.133
2.4 0.8300 251.00 0.0997 0.0182 0.06400 0.135
2.5 0.7770 316.00 0.0997 0.0186 0.06310 0.136
2.6 0.7440 398.00 0.0997 0.0200 0.06050 0.139
2.7 0.7080 501.00 0.0997 0.0207 0.05900 0.140
2.8 0.6200 631.00 0.0997 0.0237 0.05330 0.146
2.9 0.5410 794.00 0.0997 0.0270 0.04680 0.153
3.0 0.4010 1000.00 0.0997 0.0342 0.03260 0.167
3.1 0.3400 1260.00 0.0997 0.0392 0.02290 0.176
3.2 0.2510 1580.00 0.0997 0.0539 -0.00603 0.205
3.3 0.2090 2000.00 0.0997 0.0557 -0.00954 0.209
3.4 0.1890 2510.00 0.0997 0.0523 -0.00280 0.202
3.5 0.1710 3160.00 0.0997 0.0521 -0.00250 0.202
3.6 0.1680 3980.00 0.0997 0.0487 0.00428 0.195
3.7 0.1290 5010.00 0.0997 0.0414 0.01850 0.181
3.8 0.1270 6310.00 0.0997 0.0375 0.02630 0.173
3.9 0.0856 7940.00 0.0997 0.0491 0.00346 0.196
4.0 0.0385 10000.00 0.0997 0.2240 -0.34000 0.539
4.1 0.0279 12600.00 0.0997 0.2350 -0.36200 0.561

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.0952 0.0122 0.06360 0.129
0.1 1.26 0.9580 0.0928 0.0165 0.06040 0.125
0.2 1.58 0.9580 0.0928 0.0165 0.06040 0.125
0.3 2.00 0.9580 0.0928 0.0165 0.06040 0.125
0.4 2.51 0.9580 0.0928 0.0165 0.06040 0.125
0.5 3.16 0.9580 0.0928 0.0165 0.06040 0.125
0.6 3.98 0.9580 0.0928 0.0165 0.06040 0.125
0.7 5.01 0.9580 0.0928 0.0165 0.06040 0.125
0.8 6.31 0.9580 0.0928 0.0165 0.06040 0.125
0.9 7.94 0.9580 0.0928 0.0165 0.06040 0.125
1.0 10.00 0.9580 0.0928 0.0165 0.06040 0.125
1.1 12.60 0.9560 0.0932 0.0166 0.06060 0.126
1.2 15.80 0.9560 0.0932 0.0166 0.06060 0.126
1.3 20.00 0.9540 0.0915 0.0164 0.05940 0.124
1.4 25.10 0.9400 0.0936 0.0168 0.06060 0.127
1.5 31.60 0.9400 0.0936 0.0168 0.06060 0.127
1.6 39.80 0.9400 0.0936 0.0168 0.06060 0.127
1.7 50.10 0.9380 0.0918 0.0166 0.05930 0.124
1.8 63.10 0.9380 0.0918 0.0166 0.05930 0.124
1.9 79.40 0.9150 0.0947 0.0173 0.06080 0.129
2.0 100.00 0.9150 0.0947 0.0173 0.06080 0.129
2.1 126.00 0.9140 0.0932 0.0171 0.05960 0.127
2.2 158.00 0.8980 0.0884 0.0167 0.05570 0.121
2.3 200.00 0.8860 0.0889 0.0170 0.05550 0.122
2.4 251.00 0.8300 0.0929 0.0182 0.05720 0.129
2.5 316.00 0.7770 0.0905 0.0186 0.05390 0.127
2.6 398.00 0.7440 0.0932 0.0200 0.05410 0.132
2.7 501.00 0.7080 0.0927 0.0207 0.05200 0.133
2.8 631.00 0.6200 0.0980 0.0237 0.05160 0.144
2.9 794.00 0.5410 0.1070 0.0270 0.05460 0.160
3.0 1000.00 0.4010 0.1320 0.0342 0.06440 0.199
3.1 1260.00 0.3400 0.1400 0.0392 0.06330 0.217
3.2 1580.00 0.2510 0.1770 0.0539 0.07080 0.282
3.3 2000.00 0.2090 0.1620 0.0557 0.05230 0.271
3.4 2510.00 0.1890 0.1500 0.0523 0.04740 0.252
3.5 3160.00 0.1710 0.1450 0.0521 0.04260 0.247
3.6 3980.00 0.1680 0.1270 0.0487 0.03150 0.222
3.7 5010.00 0.1290 0.0922 0.0414 0.01100 0.173
3.8 6310.00 0.1270 0.0781 0.0375 0.00469 0.152
3.9 7940.00 0.0856 0.0895 0.0491 -0.00675 0.186
4.0 10000.00 0.0385 0.4350 0.2240 -0.00457 0.874
4.1 12600.00 0.0279 0.4590 0.2350 -0.00225 0.920

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 -0.211 0.226 -0.654 0.232
0.1 0.9580 1.26 -0.211 0.264 -0.727 0.306
0.2 0.9580 1.58 -0.211 0.264 -0.727 0.306
0.3 0.9580 2.00 -0.211 0.264 -0.727 0.306
0.4 0.9580 2.51 -0.211 0.264 -0.727 0.306
0.5 0.9580 3.16 -0.211 0.264 -0.727 0.306
0.6 0.9580 3.98 -0.211 0.264 -0.727 0.306
0.7 0.9580 5.01 -0.211 0.264 -0.727 0.306
0.8 0.9580 6.31 -0.211 0.264 -0.727 0.306
0.9 0.9580 7.94 -0.211 0.264 -0.727 0.306
1.0 0.9580 10.00 -0.211 0.264 -0.727 0.306
1.1 0.9560 12.60 -0.211 0.264 -0.729 0.307
1.2 0.9560 15.80 -0.211 0.264 -0.729 0.307
1.3 0.9540 20.00 -0.211 0.262 -0.725 0.303
1.4 0.9400 25.10 -0.211 0.266 -0.733 0.311
1.5 0.9400 31.60 -0.211 0.266 -0.733 0.311
1.6 0.9400 39.80 -0.211 0.266 -0.733 0.311
1.7 0.9380 50.10 -0.211 0.264 -0.729 0.307
1.8 0.9380 63.10 -0.211 0.264 -0.729 0.307
1.9 0.9150 79.40 -0.211 0.271 -0.742 0.320
2.0 0.9150 100.00 -0.211 0.271 -0.742 0.320
2.1 0.9140 126.00 -0.211 0.269 -0.739 0.317
2.2 0.8980 158.00 -0.211 0.265 -0.730 0.308
2.3 0.8860 200.00 -0.211 0.268 -0.737 0.315
2.4 0.8300 251.00 -0.211 0.279 -0.758 0.336
2.5 0.7770 316.00 -0.211 0.284 -0.767 0.345
2.6 0.7440 398.00 -0.211 0.297 -0.792 0.371
2.7 0.7080 501.00 -0.211 0.304 -0.808 0.386
2.8 0.6200 631.00 -0.211 0.334 -0.866 0.445
2.9 0.5410 794.00 -0.211 0.370 -0.935 0.514
3.0 0.4010 1000.00 -0.211 0.450 -1.090 0.670
3.1 0.3400 1260.00 -0.211 0.506 -1.200 0.780
3.2 0.2510 1580.00 -0.211 0.677 -1.540 1.120
3.3 0.2090 2000.00 -0.211 0.698 -1.580 1.160
3.4 0.1890 2510.00 -0.211 0.658 -1.500 1.080
3.5 0.1710 3160.00 -0.211 0.656 -1.500 1.070
3.6 0.1680 3980.00 -0.211 0.615 -1.420 0.995
3.7 0.1290 5010.00 -0.211 0.531 -1.250 0.830
3.8 0.1270 6310.00 -0.211 0.486 -1.160 0.742
3.9 0.0856 7940.00 -0.211 0.620 -1.430 1.000
4.0 0.0385 10000.00 -0.211 2.730 -5.560 5.140
4.1 0.0279 12600.00 -0.211 2.860 -5.830 5.400

IgG V1V2 C.1086-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.0985 0.0122 0.07460 0.122
0.1 0.9730 1.26 0.0985 0.0170 0.06520 0.132
0.2 0.9730 1.58 0.0985 0.0170 0.06520 0.132
0.3 0.9730 2.00 0.0985 0.0170 0.06520 0.132
0.4 0.9730 2.51 0.0985 0.0170 0.06520 0.132
0.5 0.9730 3.16 0.0985 0.0170 0.06520 0.132
0.6 0.9730 3.98 0.0985 0.0170 0.06520 0.132
0.7 0.9710 5.01 0.0985 0.0168 0.06560 0.131
0.8 0.9710 6.31 0.0985 0.0168 0.06560 0.131
0.9 0.9710 7.94 0.0985 0.0168 0.06560 0.131
1.0 0.9700 10.00 0.0985 0.0166 0.06600 0.131
1.1 0.9550 12.60 0.0985 0.0170 0.06510 0.132
1.2 0.9540 15.80 0.0985 0.0168 0.06550 0.132
1.3 0.9540 20.00 0.0985 0.0168 0.06550 0.132
1.4 0.9310 25.10 0.0985 0.0175 0.06410 0.133
1.5 0.9270 31.60 0.0985 0.0175 0.06420 0.133
1.6 0.9260 39.80 0.0985 0.0173 0.06460 0.132
1.7 0.9120 50.10 0.0985 0.0170 0.06510 0.132
1.8 0.9100 63.10 0.0985 0.0168 0.06560 0.131
1.9 0.8960 79.40 0.0985 0.0170 0.06520 0.132
2.0 0.8600 100.00 0.0985 0.0181 0.06300 0.134
2.1 0.8260 126.00 0.0985 0.0185 0.06210 0.135
2.2 0.8060 158.00 0.0985 0.0189 0.06140 0.136
2.3 0.7410 200.00 0.0985 0.0202 0.05890 0.138
2.4 0.6930 251.00 0.0985 0.0247 0.05000 0.147
2.5 0.5700 316.00 0.0985 0.0237 0.05210 0.145
2.6 0.5230 398.00 0.0985 0.0251 0.04920 0.148
2.7 0.4260 501.00 0.0985 0.0286 0.04250 0.155
2.8 0.3590 631.00 0.0985 0.0348 0.03040 0.167
2.9 0.2870 794.00 0.0985 0.0410 0.01800 0.179
3.0 0.2660 1000.00 0.0985 0.0378 0.02430 0.173
3.1 0.2050 1260.00 0.0985 0.0425 0.01520 0.182
3.2 0.1590 1580.00 0.0985 0.0472 0.00602 0.191
3.3 0.1390 2000.00 0.0985 0.0394 0.02130 0.176
3.4 0.1110 2510.00 0.0985 0.0405 0.01920 0.178
3.5 0.0506 3160.00 0.0985 0.0928 -0.08340 0.280
3.6 0.0263 3980.00 0.0985 0.2510 -0.39400 0.591

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.0952 0.0122 0.06360 0.129
0.1 1.26 0.9730 0.0973 0.0170 0.06400 0.131
0.2 1.58 0.9730 0.0973 0.0170 0.06400 0.131
0.3 2.00 0.9730 0.0973 0.0170 0.06400 0.131
0.4 2.51 0.9730 0.0973 0.0170 0.06400 0.131
0.5 3.16 0.9730 0.0973 0.0170 0.06400 0.131
0.6 3.98 0.9730 0.0973 0.0170 0.06400 0.131
0.7 5.01 0.9710 0.0956 0.0168 0.06280 0.129
0.8 6.31 0.9710 0.0956 0.0168 0.06280 0.129
0.9 7.94 0.9710 0.0956 0.0168 0.06280 0.129
1.0 10.00 0.9700 0.0939 0.0166 0.06140 0.126
1.1 12.60 0.9550 0.0962 0.0170 0.06280 0.130
1.2 15.80 0.9540 0.0945 0.0168 0.06150 0.128
1.3 20.00 0.9540 0.0945 0.0168 0.06150 0.128
1.4 25.10 0.9310 0.0977 0.0175 0.06330 0.132
1.5 31.60 0.9270 0.0964 0.0175 0.06220 0.131
1.6 39.80 0.9260 0.0948 0.0173 0.06090 0.129
1.7 50.10 0.9120 0.0918 0.0170 0.05840 0.125
1.8 63.10 0.9100 0.0899 0.0168 0.05700 0.123
1.9 79.40 0.8960 0.0888 0.0170 0.05560 0.122
2.0 100.00 0.8600 0.0936 0.0181 0.05800 0.129
2.1 126.00 0.8260 0.0924 0.0185 0.05600 0.129
2.2 158.00 0.8060 0.0907 0.0189 0.05350 0.128
2.3 200.00 0.7410 0.0921 0.0202 0.05250 0.132
2.4 251.00 0.6930 0.1050 0.0247 0.05690 0.154
2.5 316.00 0.5700 0.1050 0.0237 0.05830 0.151
2.6 398.00 0.5230 0.1070 0.0251 0.05800 0.156
2.7 501.00 0.4260 0.1130 0.0286 0.05700 0.169
2.8 631.00 0.3590 0.1220 0.0348 0.05430 0.190
2.9 794.00 0.2870 0.1350 0.0410 0.05500 0.216
3.0 1000.00 0.2660 0.1180 0.0378 0.04380 0.192
3.1 1260.00 0.2050 0.1100 0.0425 0.02670 0.193
3.2 1580.00 0.1590 0.1120 0.0472 0.01920 0.204
3.3 2000.00 0.1390 0.0868 0.0394 0.00965 0.164
3.4 2510.00 0.1110 0.0815 0.0405 0.00218 0.161
3.5 3160.00 0.0506 0.1160 0.0928 -0.06570 0.298
3.6 3980.00 0.0263 0.4350 0.2510 -0.05770 0.928

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 -0.196 0.224 -0.636 0.243
0.1 0.9730 1.26 -0.196 0.267 -0.719 0.326
0.2 0.9730 1.58 -0.196 0.267 -0.719 0.326
0.3 0.9730 2.00 -0.196 0.267 -0.719 0.326
0.4 0.9730 2.51 -0.196 0.267 -0.719 0.326
0.5 0.9730 3.16 -0.196 0.267 -0.719 0.326
0.6 0.9730 3.98 -0.196 0.267 -0.719 0.326
0.7 0.9710 5.01 -0.196 0.265 -0.715 0.322
0.8 0.9710 6.31 -0.196 0.265 -0.715 0.322
0.9 0.9710 7.94 -0.196 0.265 -0.715 0.322
1.0 0.9700 10.00 -0.196 0.263 -0.711 0.318
1.1 0.9550 12.60 -0.196 0.267 -0.720 0.327
1.2 0.9540 15.80 -0.196 0.265 -0.716 0.323
1.3 0.9540 20.00 -0.196 0.265 -0.716 0.323
1.4 0.9310 25.10 -0.196 0.272 -0.729 0.336
1.5 0.9270 31.60 -0.196 0.271 -0.728 0.335
1.6 0.9260 39.80 -0.196 0.269 -0.724 0.331
1.7 0.9120 50.10 -0.196 0.267 -0.720 0.327
1.8 0.9100 63.10 -0.196 0.265 -0.715 0.322
1.9 0.8960 79.40 -0.196 0.266 -0.718 0.325
2.0 0.8600 100.00 -0.196 0.277 -0.740 0.347
2.1 0.8260 126.00 -0.196 0.281 -0.748 0.355
2.2 0.8060 158.00 -0.196 0.285 -0.756 0.363
2.3 0.7410 200.00 -0.196 0.298 -0.780 0.387
2.4 0.6930 251.00 -0.196 0.344 -0.872 0.479
2.5 0.5700 316.00 -0.196 0.334 -0.850 0.457
2.6 0.5230 398.00 -0.196 0.349 -0.880 0.487
2.7 0.4260 501.00 -0.196 0.386 -0.953 0.560
2.8 0.3590 631.00 -0.196 0.455 -1.090 0.695
2.9 0.2870 794.00 -0.196 0.526 -1.230 0.835
3.0 0.2660 1000.00 -0.196 0.490 -1.160 0.763
3.1 0.2050 1260.00 -0.196 0.543 -1.260 0.868
3.2 0.1590 1580.00 -0.196 0.597 -1.370 0.974
3.3 0.1390 2000.00 -0.196 0.507 -1.190 0.798
3.4 0.1110 2510.00 -0.196 0.520 -1.210 0.822
3.5 0.0506 3160.00 -0.196 1.140 -2.430 2.040
3.6 0.0263 3980.00 -0.196 3.060 -6.190 5.800

IgG V1V2 C.1086-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.0990 0.0122 0.07510 0.123
0.1 0.9840 1.26 0.0990 0.0165 0.06660 0.131
0.2 0.9840 1.58 0.0990 0.0165 0.06660 0.131
0.3 0.9840 2.00 0.0990 0.0165 0.06660 0.131
0.4 0.9840 2.51 0.0990 0.0165 0.06660 0.131
0.5 0.9840 3.16 0.0990 0.0165 0.06660 0.131
0.6 0.9840 3.98 0.0990 0.0165 0.06660 0.131
0.7 0.9840 5.01 0.0990 0.0165 0.06660 0.131
0.8 0.9840 6.31 0.0990 0.0165 0.06660 0.131
0.9 0.9840 7.94 0.0990 0.0165 0.06660 0.131
1.0 0.9840 10.00 0.0990 0.0165 0.06660 0.131
1.1 0.9700 12.60 0.0990 0.0170 0.06570 0.132
1.2 0.9700 15.80 0.0990 0.0170 0.06570 0.132
1.3 0.9700 20.00 0.0990 0.0170 0.06570 0.132
1.4 0.9700 25.10 0.0990 0.0170 0.06570 0.132
1.5 0.9680 31.60 0.0990 0.0168 0.06600 0.132
1.6 0.9580 39.80 0.0990 0.0169 0.06590 0.132
1.7 0.9410 50.10 0.0990 0.0168 0.06600 0.132
1.8 0.9410 63.10 0.0990 0.0168 0.06600 0.132
1.9 0.9400 79.40 0.0990 0.0166 0.06640 0.132
2.0 0.9400 100.00 0.0990 0.0166 0.06640 0.132
2.1 0.9380 126.00 0.0990 0.0167 0.06630 0.132
2.2 0.8780 158.00 0.0990 0.0179 0.06380 0.134
2.3 0.8760 200.00 0.0990 0.0178 0.06410 0.134
2.4 0.8760 251.00 0.0990 0.0178 0.06410 0.134
2.5 0.8710 316.00 0.0990 0.0172 0.06530 0.133
2.6 0.8320 398.00 0.0990 0.0179 0.06400 0.134
2.7 0.7830 501.00 0.0990 0.0198 0.06010 0.138
2.8 0.7360 631.00 0.0990 0.0209 0.05810 0.140
2.9 0.6600 794.00 0.0990 0.0222 0.05550 0.142
3.0 0.6200 1000.00 0.0990 0.0236 0.05270 0.145
3.1 0.5880 1260.00 0.0990 0.0225 0.05490 0.143
3.2 0.5130 1580.00 0.0990 0.0268 0.04650 0.151
3.3 0.4550 2000.00 0.0990 0.0304 0.03930 0.159
3.4 0.3850 2510.00 0.0990 0.0313 0.03760 0.160
3.5 0.3240 3160.00 0.0990 0.0346 0.03110 0.167
3.6 0.2410 3980.00 0.0990 0.0610 -0.02060 0.219
3.7 0.1950 5010.00 0.0990 0.0571 -0.01300 0.211
3.8 0.1770 6310.00 0.0990 0.0521 -0.00310 0.201
3.9 0.1680 7940.00 0.0990 0.0457 0.00948 0.188
4.0 0.1260 10000.00 0.0990 0.0568 -0.01230 0.210
4.1 0.1220 12600.00 0.0990 0.0558 -0.01030 0.208
4.2 0.1060 15800.00 0.0990 0.0519 -0.00284 0.201
4.3 0.0878 20000.00 0.0917 0.0484 -0.00310 0.187

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.0952 0.0122 0.0636 0.129
0.1 1.26 0.9840 0.0935 0.0165 0.0611 0.126
0.2 1.58 0.9840 0.0935 0.0165 0.0611 0.126
0.3 2.00 0.9840 0.0935 0.0165 0.0611 0.126
0.4 2.51 0.9840 0.0935 0.0165 0.0611 0.126
0.5 3.16 0.9840 0.0935 0.0165 0.0611 0.126
0.6 3.98 0.9840 0.0935 0.0165 0.0611 0.126
0.7 5.01 0.9840 0.0935 0.0165 0.0611 0.126
0.8 6.31 0.9840 0.0935 0.0165 0.0611 0.126
0.9 7.94 0.9840 0.0935 0.0165 0.0611 0.126
1.0 10.00 0.9840 0.0935 0.0165 0.0611 0.126
1.1 12.60 0.9700 0.0959 0.0170 0.0626 0.129
1.2 15.80 0.9700 0.0959 0.0170 0.0626 0.129
1.3 20.00 0.9700 0.0959 0.0170 0.0626 0.129
1.4 25.10 0.9700 0.0959 0.0170 0.0626 0.129
1.5 31.60 0.9680 0.0943 0.0168 0.0614 0.127
1.6 39.80 0.9580 0.0947 0.0169 0.0615 0.128
1.7 50.10 0.9410 0.0936 0.0168 0.0606 0.127
1.8 63.10 0.9410 0.0936 0.0168 0.0606 0.127
1.9 79.40 0.9400 0.0918 0.0166 0.0593 0.124
2.0 100.00 0.9400 0.0918 0.0166 0.0593 0.124
2.1 126.00 0.9380 0.0922 0.0167 0.0595 0.125
2.2 158.00 0.8780 0.0976 0.0179 0.0624 0.133
2.3 200.00 0.8760 0.0960 0.0178 0.0612 0.131
2.4 251.00 0.8760 0.0960 0.0178 0.0612 0.131
2.5 316.00 0.8710 0.0906 0.0172 0.0570 0.124
2.6 398.00 0.8320 0.0928 0.0179 0.0578 0.128
2.7 501.00 0.7830 0.0986 0.0198 0.0598 0.137
2.8 631.00 0.7360 0.0978 0.0209 0.0569 0.139
2.9 794.00 0.6600 0.1000 0.0222 0.0567 0.144
3.0 1000.00 0.6200 0.1020 0.0236 0.0555 0.148
3.1 1260.00 0.5880 0.0916 0.0225 0.0475 0.136
3.2 1580.00 0.5130 0.1020 0.0268 0.0491 0.154
3.3 2000.00 0.4550 0.1150 0.0304 0.0555 0.175
3.4 2510.00 0.3850 0.1200 0.0313 0.0582 0.181
3.5 3160.00 0.3240 0.1180 0.0346 0.0499 0.186
3.6 3980.00 0.2410 0.1710 0.0610 0.0512 0.290
3.7 5010.00 0.1950 0.1600 0.0571 0.0482 0.272
3.8 6310.00 0.1770 0.1430 0.0521 0.0413 0.245
3.9 7940.00 0.1680 0.1100 0.0457 0.0204 0.199
4.0 10000.00 0.1260 0.1350 0.0568 0.0241 0.247
4.1 12600.00 0.1220 0.1260 0.0558 0.0167 0.235
4.2 15800.00 0.1060 0.1160 0.0519 0.0137 0.217
4.3 20000.00 0.0878 0.0917 0.0484 -0.0031 0.187

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 -0.202 0.225 -0.643 0.239
0.1 0.9840 1.26 -0.202 0.263 -0.717 0.312
0.2 0.9840 1.58 -0.202 0.263 -0.717 0.312
0.3 0.9840 2.00 -0.202 0.263 -0.717 0.312
0.4 0.9840 2.51 -0.202 0.263 -0.717 0.312
0.5 0.9840 3.16 -0.202 0.263 -0.717 0.312
0.6 0.9840 3.98 -0.202 0.263 -0.717 0.312
0.7 0.9840 5.01 -0.202 0.263 -0.717 0.312
0.8 0.9840 6.31 -0.202 0.263 -0.717 0.312
0.9 0.9840 7.94 -0.202 0.263 -0.717 0.312
1.0 0.9840 10.00 -0.202 0.263 -0.717 0.312
1.1 0.9700 12.60 -0.202 0.267 -0.726 0.321
1.2 0.9700 15.80 -0.202 0.267 -0.726 0.321
1.3 0.9700 20.00 -0.202 0.267 -0.726 0.321
1.4 0.9700 25.10 -0.202 0.267 -0.726 0.321
1.5 0.9680 31.60 -0.202 0.266 -0.723 0.318
1.6 0.9580 39.80 -0.202 0.266 -0.724 0.319
1.7 0.9410 50.10 -0.202 0.265 -0.723 0.318
1.8 0.9410 63.10 -0.202 0.265 -0.723 0.318
1.9 0.9400 79.40 -0.202 0.263 -0.719 0.314
2.0 0.9400 100.00 -0.202 0.263 -0.719 0.314
2.1 0.9380 126.00 -0.202 0.264 -0.720 0.315
2.2 0.8780 158.00 -0.202 0.276 -0.743 0.339
2.3 0.8760 200.00 -0.202 0.274 -0.740 0.336
2.4 0.8760 251.00 -0.202 0.274 -0.740 0.336
2.5 0.8710 316.00 -0.202 0.269 -0.729 0.324
2.6 0.8320 398.00 -0.202 0.275 -0.742 0.337
2.7 0.7830 501.00 -0.202 0.294 -0.779 0.375
2.8 0.7360 631.00 -0.202 0.305 -0.800 0.395
2.9 0.6600 794.00 -0.202 0.318 -0.826 0.421
3.0 0.6200 1000.00 -0.202 0.333 -0.855 0.450
3.1 0.5880 1260.00 -0.202 0.321 -0.832 0.427
3.2 0.5130 1580.00 -0.202 0.367 -0.922 0.517
3.3 0.4550 2000.00 -0.202 0.407 -0.999 0.595
3.4 0.3850 2510.00 -0.202 0.416 -1.020 0.614
3.5 0.3240 3160.00 -0.202 0.454 -1.090 0.687
3.6 0.2410 3980.00 -0.202 0.760 -1.690 1.290
3.7 0.1950 5010.00 -0.202 0.714 -1.600 1.200
3.8 0.1770 6310.00 -0.202 0.655 -1.490 1.080
3.9 0.1680 7940.00 -0.202 0.580 -1.340 0.934
4.0 0.1260 10000.00 -0.202 0.710 -1.590 1.190
4.1 0.1220 12600.00 -0.202 0.698 -1.570 1.170
4.2 0.1060 15800.00 -0.202 0.653 -1.480 1.080
4.3 0.0878 20000.00 -0.114 0.608 -1.310 1.080

IgG3 V1V2 B.CaseA-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.181 0.0122 0.15800 0.205
0.1 0.2810 1.26 0.181 0.0387 0.10600 0.257
0.2 0.2810 1.58 0.181 0.0387 0.10600 0.257
0.3 0.2810 2.00 0.181 0.0387 0.10600 0.257
0.4 0.2550 2.51 0.181 0.0394 0.10400 0.259
0.5 0.2530 3.16 0.181 0.0383 0.10600 0.257
0.6 0.2300 3.98 0.181 0.0503 0.08280 0.280
0.7 0.2080 5.01 0.181 0.0523 0.07890 0.284
0.8 0.1920 6.31 0.181 0.0688 0.04670 0.316
0.9 0.1920 7.94 0.181 0.0688 0.04670 0.316
1.0 0.1330 10.00 0.181 0.0977 -0.01000 0.373
1.1 0.1330 12.60 0.181 0.0977 -0.01000 0.373
1.2 0.1310 15.80 0.181 0.0967 -0.00817 0.371
1.3 0.1200 20.00 0.181 0.1080 -0.02990 0.393
1.4 0.1190 25.10 0.181 0.1050 -0.02400 0.387
1.5 0.1170 31.60 0.181 0.1080 -0.02990 0.393
1.6 0.1070 39.80 0.181 0.1020 -0.01850 0.381
1.7 0.0574 50.10 0.181 0.1240 -0.06070 0.424
1.8 0.0556 63.10 0.181 0.1270 -0.06770 0.431
1.9 0.0539 79.40 0.181 0.1360 -0.08580 0.449
2.0 0.0418 100.00 0.181 0.1420 -0.09670 0.460
2.1 0.0418 126.00 0.181 0.1420 -0.09670 0.460
2.2 0.0383 158.00 0.181 0.1580 -0.12900 0.492
2.3 0.0383 200.00 0.181 0.1580 -0.12900 0.492
2.4 0.0383 251.00 0.181 0.1580 -0.12900 0.492
2.5 0.0383 316.00 0.181 0.1580 -0.12900 0.492
2.6 0.0365 398.00 0.181 0.1130 -0.03990 0.403
2.7 0.0365 501.00 0.181 0.1130 -0.03990 0.403
2.8 0.0365 631.00 0.181 0.1130 -0.03990 0.403

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.0952 0.0122 0.0648 0.130
0.1 1.26 0.2810 0.1150 0.0387 0.0389 0.191
0.2 1.58 0.2810 0.1150 0.0387 0.0389 0.191
0.3 2.00 0.2810 0.1150 0.0387 0.0389 0.191
0.4 2.51 0.2550 0.1110 0.0394 0.0340 0.188
0.5 3.16 0.2530 0.1060 0.0383 0.0308 0.181
0.6 3.98 0.2300 0.1230 0.0503 0.0246 0.222
0.7 5.01 0.2080 0.1350 0.0523 0.0323 0.237
0.8 6.31 0.1920 0.1740 0.0688 0.0388 0.308
0.9 7.94 0.1920 0.1740 0.0688 0.0388 0.308
1.0 10.00 0.1330 0.2710 0.0977 0.0797 0.463
1.1 12.60 0.1330 0.2710 0.0977 0.0797 0.463
1.2 15.80 0.1310 0.2610 0.0967 0.0718 0.451
1.3 20.00 0.1200 0.2870 0.1080 0.0759 0.498
1.4 25.10 0.1190 0.2760 0.1050 0.0709 0.482
1.5 31.60 0.1170 0.2630 0.1080 0.0518 0.474
1.6 39.80 0.1070 0.4530 0.1020 0.2530 0.653
1.7 50.10 0.0574 0.5390 0.1240 0.2970 0.781
1.8 63.10 0.0556 0.5400 0.1270 0.2910 0.789
1.9 79.40 0.0539 0.5300 0.1360 0.2630 0.797
2.0 100.00 0.0418 0.5220 0.1420 0.2440 0.800
2.1 126.00 0.0418 0.5220 0.1420 0.2440 0.800
2.2 158.00 0.0383 0.5010 0.1580 0.1910 0.811
2.3 200.00 0.0383 0.5010 0.1580 0.1910 0.811
2.4 251.00 0.0383 0.5010 0.1580 0.1910 0.811
2.5 316.00 0.0383 0.5010 0.1580 0.1910 0.811
2.6 398.00 0.0365 0.3660 0.1130 0.1450 0.588
2.7 501.00 0.0365 0.3660 0.1130 0.1450 0.588
2.8 631.00 0.0365 0.3660 0.1130 0.1450 0.588

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 -1.2 0.344 -1.88 -0.5290
0.1 0.2810 1.26 -1.2 0.563 -2.31 -0.0998
0.2 0.2810 1.58 -1.2 0.563 -2.31 -0.0998
0.3 0.2810 2.00 -1.2 0.563 -2.31 -0.0998
0.4 0.2550 2.51 -1.2 0.571 -2.32 -0.0855
0.5 0.2530 3.16 -1.2 0.560 -2.30 -0.1070
0.6 0.2300 3.98 -1.2 0.686 -2.55 0.1400
0.7 0.2080 5.01 -1.2 0.707 -2.59 0.1830
0.8 0.1920 6.31 -1.2 0.891 -2.95 0.5430
0.9 0.1920 7.94 -1.2 0.891 -2.95 0.5430
1.0 0.1330 10.00 -1.2 1.230 -3.61 1.2000
1.1 0.1330 12.60 -1.2 1.230 -3.61 1.2000
1.2 0.1310 15.80 -1.2 1.220 -3.59 1.1800
1.3 0.1200 20.00 -1.2 1.350 -3.84 1.4300
1.4 0.1190 25.10 -1.2 1.310 -3.77 1.3600
1.5 0.1170 31.60 -1.2 1.350 -3.84 1.4300
1.6 0.1070 39.80 -1.2 1.280 -3.71 1.3000
1.7 0.0574 50.10 -1.2 1.530 -4.21 1.8000
1.8 0.0556 63.10 -1.2 1.580 -4.29 1.8800
1.9 0.0539 79.40 -1.2 1.690 -4.51 2.1000
2.0 0.0418 100.00 -1.2 1.750 -4.64 2.2300
2.1 0.0418 126.00 -1.2 1.750 -4.64 2.2300
2.2 0.0383 158.00 -1.2 1.950 -5.02 2.6200
2.3 0.0383 200.00 -1.2 1.950 -5.02 2.6200
2.4 0.0383 251.00 -1.2 1.950 -5.02 2.6200
2.5 0.0383 316.00 -1.2 1.950 -5.02 2.6200
2.6 0.0365 398.00 -1.2 1.410 -3.96 1.5500
2.7 0.0365 501.00 -1.2 1.410 -3.96 1.5500
2.8 0.0365 631.00 -1.2 1.410 -3.96 1.5500

IgG3 V1V2 AE.A244-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.154 0.0122 0.13000 0.178
0.1 0.9130 1.26 0.154 0.0184 0.11800 0.190
0.2 0.9130 1.58 0.154 0.0184 0.11800 0.190
0.3 0.9120 2.00 0.154 0.0183 0.11800 0.190
0.4 0.8580 2.51 0.154 0.0194 0.11600 0.192
0.5 0.8580 3.16 0.154 0.0194 0.11600 0.192
0.6 0.8560 3.98 0.154 0.0192 0.11600 0.192
0.7 0.8330 5.01 0.154 0.0199 0.11500 0.193
0.8 0.7950 6.31 0.154 0.0205 0.11400 0.194
0.9 0.7910 7.94 0.154 0.0200 0.11500 0.193
1.0 0.7840 10.00 0.154 0.0190 0.11700 0.191
1.1 0.7840 12.60 0.154 0.0190 0.11700 0.191
1.2 0.7340 15.80 0.154 0.0215 0.11200 0.196
1.3 0.6930 20.00 0.154 0.0252 0.10500 0.203
1.4 0.6550 25.10 0.154 0.0284 0.09830 0.210
1.5 0.5710 31.60 0.154 0.0349 0.08560 0.222
1.6 0.5370 39.80 0.154 0.0316 0.09210 0.216
1.7 0.4730 50.10 0.154 0.0322 0.09080 0.217
1.8 0.4460 63.10 0.154 0.0336 0.08800 0.220
1.9 0.4100 79.40 0.154 0.0396 0.07640 0.232
2.0 0.3940 100.00 0.154 0.0430 0.06970 0.238
2.1 0.3730 126.00 0.154 0.0468 0.06230 0.246
2.2 0.3250 158.00 0.154 0.0544 0.04740 0.261
2.3 0.2920 200.00 0.154 0.0529 0.05040 0.258
2.4 0.2150 251.00 0.154 0.0812 -0.00514 0.313
2.5 0.2050 316.00 0.154 0.0978 -0.03760 0.346
2.6 0.1310 398.00 0.154 0.0955 -0.03320 0.341
2.7 0.1160 501.00 0.154 0.1120 -0.06470 0.373
2.8 0.0907 631.00 0.154 0.1330 -0.10800 0.416
2.9 0.0907 794.00 0.154 0.1330 -0.10800 0.416
3.0 0.0630 1000.00 0.154 0.2440 -0.32500 0.632
3.1 0.0612 1260.00 0.154 0.2440 -0.32500 0.633
3.2 0.0578 1580.00 0.154 0.2500 -0.33500 0.643
3.3 0.0335 2000.00 0.154 0.2210 -0.27900 0.587
3.4 0.0318 2510.00 0.154 0.2270 -0.29200 0.600
3.5 0.0156 3160.00 0.154 0.2810 -0.39700 0.705
3.6 0.0156 3980.00 0.154 0.2810 -0.39700 0.705
3.7 0.0156 5010.00 0.154 0.2810 -0.39700 0.705
3.8 0.0156 6310.00 0.154 0.2810 -0.39700 0.705

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.0952 0.0122 0.0648 0.130
0.1 1.26 0.9130 0.1010 0.0184 0.0650 0.137
0.2 1.58 0.9130 0.1010 0.0184 0.0650 0.137
0.3 2.00 0.9120 0.0995 0.0183 0.0637 0.135
0.4 2.51 0.8580 0.1050 0.0194 0.0667 0.143
0.5 3.16 0.8580 0.1050 0.0194 0.0667 0.143
0.6 3.98 0.8560 0.1030 0.0192 0.0653 0.141
0.7 5.01 0.8330 0.1040 0.0199 0.0655 0.143
0.8 6.31 0.7950 0.1070 0.0205 0.0673 0.148
0.9 7.94 0.7910 0.1030 0.0200 0.0641 0.143
1.0 10.00 0.7840 0.0950 0.0190 0.0578 0.132
1.1 12.60 0.7840 0.0950 0.0190 0.0578 0.132
1.2 15.80 0.7340 0.1060 0.0215 0.0640 0.148
1.3 20.00 0.6930 0.1250 0.0252 0.0758 0.174
1.4 25.10 0.6550 0.1370 0.0284 0.0818 0.193
1.5 31.60 0.5710 0.1520 0.0349 0.0838 0.221
1.6 39.80 0.5370 0.1430 0.0316 0.0812 0.205
1.7 50.10 0.4730 0.1460 0.0322 0.0826 0.209
1.8 63.10 0.4460 0.1460 0.0336 0.0803 0.212
1.9 79.40 0.4100 0.1530 0.0396 0.0758 0.231
2.0 100.00 0.3940 0.1820 0.0430 0.0976 0.266
2.1 126.00 0.3730 0.1960 0.0468 0.1040 0.288
2.2 158.00 0.3250 0.2210 0.0544 0.1150 0.328
2.3 200.00 0.2920 0.2220 0.0529 0.1180 0.326
2.4 251.00 0.2150 0.3310 0.0812 0.1710 0.490
2.5 316.00 0.2050 0.3180 0.0978 0.1270 0.510
2.6 398.00 0.1310 0.3330 0.0955 0.1460 0.520
2.7 501.00 0.1160 0.3550 0.1120 0.1370 0.574
2.8 631.00 0.0907 0.4560 0.1330 0.1950 0.718
2.9 794.00 0.0907 0.4560 0.1330 0.1950 0.718
3.0 1000.00 0.0630 0.6290 0.2440 0.1510 1.110
3.1 1260.00 0.0612 0.6340 0.2440 0.1550 1.110
3.2 1580.00 0.0578 0.6370 0.2500 0.1480 1.130
3.3 2000.00 0.0335 0.6230 0.2210 0.1900 1.060
3.4 2510.00 0.0318 0.6060 0.2270 0.1610 1.050
3.5 3160.00 0.0156 0.5760 0.2810 0.0248 1.130
3.6 3980.00 0.0156 0.5760 0.2810 0.0248 1.130
3.7 5010.00 0.0156 0.5760 0.2810 0.0248 1.130
3.8 6310.00 0.0156 0.5760 0.2810 0.0248 1.130

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 -0.87 0.302 -1.46 -0.2780
0.1 0.9130 1.26 -0.87 0.346 -1.55 -0.1920
0.2 0.9130 1.58 -0.87 0.346 -1.55 -0.1920
0.3 0.9120 2.00 -0.87 0.345 -1.55 -0.1950
0.4 0.8580 2.51 -0.87 0.354 -1.56 -0.1770
0.5 0.8580 3.16 -0.87 0.354 -1.56 -0.1770
0.6 0.8560 3.98 -0.87 0.352 -1.56 -0.1800
0.7 0.8330 5.01 -0.87 0.357 -1.57 -0.1700
0.8 0.7950 6.31 -0.87 0.363 -1.58 -0.1590
0.9 0.7910 7.94 -0.87 0.359 -1.57 -0.1670
1.0 0.7840 10.00 -0.87 0.350 -1.56 -0.1840
1.1 0.7840 12.60 -0.87 0.350 -1.56 -0.1840
1.2 0.7340 15.80 -0.87 0.371 -1.60 -0.1430
1.3 0.6930 20.00 -0.87 0.404 -1.66 -0.0790
1.4 0.6550 25.10 -0.87 0.434 -1.72 -0.0197
1.5 0.5710 31.60 -0.87 0.499 -1.85 0.1080
1.6 0.5370 39.80 -0.87 0.465 -1.78 0.0418
1.7 0.4730 50.10 -0.87 0.472 -1.80 0.0545
1.8 0.4460 63.10 -0.87 0.486 -1.82 0.0829
1.9 0.4100 79.40 -0.87 0.549 -1.95 0.2050
2.0 0.3940 100.00 -0.87 0.585 -2.02 0.2760
2.1 0.3730 126.00 -0.87 0.626 -2.10 0.3570
2.2 0.3250 158.00 -0.87 0.711 -2.26 0.5230
2.3 0.2920 200.00 -0.87 0.694 -2.23 0.4900
2.4 0.2150 251.00 -0.87 1.020 -2.87 1.1300
2.5 0.2050 316.00 -0.87 1.220 -3.25 1.5100
2.6 0.1310 398.00 -0.87 1.190 -3.20 1.4600
2.7 0.1160 501.00 -0.87 1.380 -3.58 1.8400
2.8 0.0907 631.00 -0.87 1.640 -4.09 2.3500
2.9 0.0907 794.00 -0.87 1.640 -4.09 2.3500
3.0 0.0630 1000.00 -0.87 2.980 -6.71 4.9700
3.1 0.0612 1260.00 -0.87 2.980 -6.71 4.9700
3.2 0.0578 1580.00 -0.87 3.040 -6.83 5.0900
3.3 0.0335 2000.00 -0.87 2.690 -6.15 4.4100
3.4 0.0318 2510.00 -0.87 2.780 -6.31 4.5700
3.5 0.0156 3160.00 -0.87 3.420 -7.58 5.8400
3.6 0.0156 3980.00 -0.87 3.420 -7.58 5.8400
3.7 0.0156 5010.00 -0.87 3.420 -7.58 5.8400
3.8 0.0156 6310.00 -0.87 3.420 -7.58 5.8400

IgG3 V1V2 C.1086-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.171 0.0122 0.1470 0.195
0.1 0.9000 1.26 0.171 0.0165 0.1390 0.204
0.2 0.8900 1.58 0.171 0.0170 0.1380 0.205
0.3 0.8900 2.00 0.171 0.0170 0.1380 0.205
0.4 0.8610 2.51 0.171 0.0179 0.1360 0.206
0.5 0.8430 3.16 0.171 0.0175 0.1370 0.206
0.6 0.8140 3.98 0.171 0.0189 0.1340 0.208
0.7 0.7960 5.01 0.171 0.0195 0.1330 0.209
0.8 0.7320 6.31 0.171 0.0212 0.1300 0.213
0.9 0.7070 7.94 0.171 0.0236 0.1250 0.217
1.0 0.6880 10.00 0.171 0.0250 0.1220 0.220
1.1 0.6240 12.60 0.171 0.0279 0.1170 0.226
1.2 0.5730 15.80 0.171 0.0268 0.1190 0.224
1.3 0.5170 20.00 0.171 0.0256 0.1210 0.221
1.4 0.4800 25.10 0.171 0.0284 0.1150 0.227
1.5 0.4400 31.60 0.171 0.0330 0.1070 0.236
1.6 0.4190 39.80 0.171 0.0385 0.0958 0.247
1.7 0.3860 50.10 0.171 0.0448 0.0833 0.259
1.8 0.3510 63.10 0.171 0.0455 0.0821 0.260
1.9 0.3020 79.40 0.171 0.0564 0.0606 0.282
2.0 0.2350 100.00 0.171 0.1290 -0.0821 0.424
2.1 0.1480 126.00 0.171 0.1050 -0.0345 0.377
2.2 0.1220 158.00 0.171 0.1010 -0.0267 0.369
2.3 0.1030 200.00 0.171 0.1170 -0.0584 0.401
2.4 0.0924 251.00 0.171 0.1270 -0.0777 0.420
2.5 0.0681 316.00 0.171 0.2300 -0.2790 0.621
2.6 0.0646 398.00 0.171 0.2370 -0.2930 0.635
2.7 0.0403 501.00 0.171 0.2400 -0.2990 0.641
2.8 0.0352 631.00 0.171 0.2540 -0.3270 0.670
2.9 0.0335 794.00 0.171 0.2620 -0.3420 0.684
3.0 0.0173 1000.00 0.171 0.2650 -0.3490 0.691
3.1 0.0156 1260.00 0.171 0.2810 -0.3800 0.722
3.2 0.0156 1580.00 0.171 0.2810 -0.3800 0.722
3.3 0.0156 2000.00 0.171 0.2810 -0.3800 0.722

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.0952 0.0122 0.0648 0.130
0.1 1.26 0.9000 0.0893 0.0165 0.0569 0.122
0.2 1.58 0.8900 0.0913 0.0170 0.0580 0.125
0.3 2.00 0.8900 0.0913 0.0170 0.0580 0.125
0.4 2.51 0.8610 0.0954 0.0179 0.0603 0.130
0.5 3.16 0.8430 0.0920 0.0175 0.0576 0.126
0.6 3.98 0.8140 0.0985 0.0189 0.0614 0.136
0.7 5.01 0.7960 0.1000 0.0195 0.0618 0.138
0.8 6.31 0.7320 0.1060 0.0212 0.0642 0.147
0.9 7.94 0.7070 0.1160 0.0236 0.0694 0.162
1.0 10.00 0.6880 0.1220 0.0250 0.0731 0.171
1.1 12.60 0.6240 0.1310 0.0279 0.0766 0.186
1.2 15.80 0.5730 0.1260 0.0268 0.0732 0.178
1.3 20.00 0.5170 0.1160 0.0256 0.0658 0.166
1.4 25.10 0.4800 0.1230 0.0284 0.0673 0.179
1.5 31.60 0.4400 0.1320 0.0330 0.0676 0.197
1.6 39.80 0.4190 0.1520 0.0385 0.0770 0.228
1.7 50.10 0.3860 0.1970 0.0448 0.1100 0.285
1.8 63.10 0.3510 0.1990 0.0455 0.1100 0.288
1.9 79.40 0.3020 0.2320 0.0564 0.1220 0.343
2.0 100.00 0.2350 0.3880 0.1290 0.1350 0.641
2.1 126.00 0.1480 0.3940 0.1050 0.1880 0.600
2.2 158.00 0.1220 0.3610 0.1010 0.1630 0.559
2.3 200.00 0.1030 0.4030 0.1170 0.1730 0.633
2.4 251.00 0.0924 0.4460 0.1270 0.1970 0.695
2.5 316.00 0.0681 0.6540 0.2300 0.2040 1.100
2.6 398.00 0.0646 0.6470 0.2370 0.1830 1.110
2.7 501.00 0.0403 0.7550 0.2400 0.2850 1.230
2.8 631.00 0.0352 0.7180 0.2540 0.2190 1.220
2.9 794.00 0.0335 0.7030 0.2620 0.1900 1.220
3.0 1000.00 0.0173 0.6110 0.2650 0.0910 1.130
3.1 1260.00 0.0156 0.5760 0.2810 0.0248 1.130
3.2 1580.00 0.0156 0.5760 0.2810 0.0248 1.130
3.3 2000.00 0.0156 0.5760 0.2810 0.0248 1.130

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 -1.08 0.328 -1.72 -0.43600
0.1 0.9000 1.26 -1.08 0.355 -1.78 -0.38300
0.2 0.8900 1.58 -1.08 0.359 -1.78 -0.37700
0.3 0.8900 2.00 -1.08 0.359 -1.78 -0.37700
0.4 0.8610 2.51 -1.08 0.365 -1.79 -0.36400
0.5 0.8430 3.16 -1.08 0.362 -1.79 -0.37000
0.6 0.8140 3.98 -1.08 0.373 -1.81 -0.34900
0.7 0.7960 5.01 -1.08 0.377 -1.82 -0.34000
0.8 0.7320 6.31 -1.08 0.390 -1.84 -0.31400
0.9 0.7070 7.94 -1.08 0.410 -1.88 -0.27600
1.0 0.6880 10.00 -1.08 0.422 -1.91 -0.25200
1.1 0.6240 12.60 -1.08 0.448 -1.96 -0.20200
1.2 0.5730 15.80 -1.08 0.438 -1.94 -0.22100
1.3 0.5170 20.00 -1.08 0.428 -1.92 -0.24100
1.4 0.4800 25.10 -1.08 0.453 -1.97 -0.19200
1.5 0.4400 31.60 -1.08 0.496 -2.05 -0.10700
1.6 0.4190 39.80 -1.08 0.551 -2.16 0.00141
1.7 0.3860 50.10 -1.08 0.619 -2.29 0.13300
1.8 0.3510 63.10 -1.08 0.625 -2.31 0.14600
1.9 0.3020 79.40 -1.08 0.745 -2.54 0.38100
2.0 0.2350 100.00 -1.08 1.600 -4.21 2.05000
2.1 0.1480 126.00 -1.08 1.310 -3.64 1.48000
2.2 0.1220 158.00 -1.08 1.260 -3.55 1.39000
2.3 0.1030 200.00 -1.08 1.450 -3.93 1.77000
2.4 0.0924 251.00 -1.08 1.570 -4.16 2.00000
2.5 0.0681 316.00 -1.08 2.800 -6.58 4.42000
2.6 0.0646 398.00 -1.08 2.890 -6.75 4.59000
2.7 0.0403 501.00 -1.08 2.930 -6.82 4.66000
2.8 0.0352 631.00 -1.08 3.100 -7.16 5.00000
2.9 0.0335 794.00 -1.08 3.190 -7.34 5.18000
3.0 0.0173 1000.00 -1.08 3.240 -7.42 5.26000
3.1 0.0156 1260.00 -1.08 3.430 -7.80 5.64000
3.2 0.0156 1580.00 -1.08 3.430 -7.80 5.64000
3.3 0.0156 2000.00 -1.08 3.430 -7.80 5.64000

IgG3 V1V2 C.1086-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.162 0.0122 0.1380 0.186
0.1 0.6850 1.26 0.162 0.0227 0.1180 0.207
0.2 0.6850 1.58 0.162 0.0227 0.1180 0.207
0.3 0.6830 2.00 0.162 0.0225 0.1180 0.206
0.4 0.6830 2.51 0.162 0.0225 0.1180 0.206
0.5 0.6580 3.16 0.162 0.0238 0.1160 0.209
0.6 0.6420 3.98 0.162 0.0248 0.1140 0.211
0.7 0.6420 5.01 0.162 0.0248 0.1140 0.211
0.8 0.6400 6.31 0.162 0.0245 0.1140 0.210
0.9 0.6400 7.94 0.162 0.0245 0.1140 0.210
1.0 0.6260 10.00 0.162 0.0263 0.1110 0.214
1.1 0.6030 12.60 0.162 0.0284 0.1070 0.218
1.2 0.6000 15.80 0.162 0.0278 0.1080 0.217
1.3 0.5850 20.00 0.162 0.0294 0.1050 0.220
1.4 0.5600 25.10 0.162 0.0302 0.1030 0.221
1.5 0.5360 31.60 0.162 0.0332 0.0972 0.227
1.6 0.4890 39.80 0.162 0.0403 0.0832 0.241
1.7 0.4860 50.10 0.162 0.0396 0.0846 0.240
1.8 0.4860 63.10 0.162 0.0396 0.0846 0.240
1.9 0.4610 79.40 0.162 0.0432 0.0776 0.247
2.0 0.4260 100.00 0.162 0.0397 0.0844 0.240
2.1 0.3420 126.00 0.162 0.0440 0.0760 0.248
2.2 0.3410 158.00 0.162 0.0435 0.0770 0.247
2.3 0.3370 200.00 0.162 0.0426 0.0787 0.246
2.4 0.2950 251.00 0.162 0.0528 0.0587 0.266
2.5 0.2940 316.00 0.162 0.0526 0.0592 0.265
2.6 0.2550 398.00 0.162 0.0545 0.0554 0.269
2.7 0.2270 501.00 0.162 0.0738 0.0175 0.307
2.8 0.1880 631.00 0.162 0.0960 -0.0259 0.350
2.9 0.1370 794.00 0.162 0.0945 -0.0229 0.347
3.0 0.0995 1000.00 0.162 0.1200 -0.0721 0.397
3.1 0.0977 1260.00 0.162 0.1270 -0.0862 0.411
3.2 0.0872 1580.00 0.162 0.1390 -0.1100 0.435
3.3 0.0629 2000.00 0.162 0.2420 -0.3110 0.636
3.4 0.0612 2510.00 0.162 0.2470 -0.3210 0.646
3.5 0.0369 3160.00 0.162 0.2540 -0.3350 0.660
3.6 0.0335 3980.00 0.162 0.2620 -0.3510 0.676
3.7 0.0317 5010.00 0.162 0.2700 -0.3670 0.692
3.8 0.0317 6310.00 0.162 0.2700 -0.3670 0.692
3.9 0.0156 7940.00 0.162 0.2810 -0.3890 0.713
4.0 0.0156 10000.00 0.162 0.2810 -0.3890 0.713
4.1 0.0156 12600.00 0.162 0.2810 -0.3890 0.713

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.0952 0.0122 0.0648 0.130
0.1 1.26 0.6850 0.1110 0.0227 0.0665 0.156
0.2 1.58 0.6850 0.1110 0.0227 0.0665 0.156
0.3 2.00 0.6830 0.1090 0.0225 0.0649 0.153
0.4 2.51 0.6830 0.1090 0.0225 0.0649 0.153
0.5 3.16 0.6580 0.1140 0.0238 0.0676 0.161
0.6 3.98 0.6420 0.1170 0.0248 0.0685 0.166
0.7 5.01 0.6420 0.1170 0.0248 0.0685 0.166
0.8 6.31 0.6400 0.1150 0.0245 0.0669 0.163
0.9 7.94 0.6400 0.1150 0.0245 0.0669 0.163
1.0 10.00 0.6260 0.1220 0.0263 0.0708 0.174
1.1 12.60 0.6030 0.1280 0.0284 0.0727 0.184
1.2 15.80 0.6000 0.1240 0.0278 0.0692 0.178
1.3 20.00 0.5850 0.1300 0.0294 0.0724 0.187
1.4 25.10 0.5600 0.1310 0.0302 0.0724 0.191
1.5 31.60 0.5360 0.1380 0.0332 0.0725 0.203
1.6 39.80 0.4890 0.1640 0.0403 0.0846 0.243
1.7 50.10 0.4860 0.1580 0.0396 0.0800 0.235
1.8 63.10 0.4860 0.1580 0.0396 0.0800 0.235
1.9 79.40 0.4610 0.1670 0.0432 0.0828 0.252
2.0 100.00 0.4260 0.1600 0.0397 0.0825 0.238
2.1 126.00 0.3420 0.1760 0.0440 0.0894 0.262
2.2 158.00 0.3410 0.1690 0.0435 0.0841 0.255
2.3 200.00 0.3370 0.1640 0.0426 0.0802 0.247
2.4 251.00 0.2950 0.2300 0.0528 0.1260 0.333
2.5 316.00 0.2940 0.2260 0.0526 0.1230 0.329
2.6 398.00 0.2550 0.2230 0.0545 0.1160 0.330
2.7 501.00 0.2270 0.3110 0.0738 0.1660 0.456
2.8 631.00 0.1880 0.3280 0.0960 0.1400 0.516
2.9 794.00 0.1370 0.3000 0.0945 0.1150 0.486
3.0 1000.00 0.0995 0.3730 0.1200 0.1390 0.608
3.1 1260.00 0.0977 0.3760 0.1270 0.1280 0.625
3.2 1580.00 0.0872 0.4340 0.1390 0.1620 0.707
3.3 2000.00 0.0629 0.6380 0.2420 0.1650 1.110
3.4 2510.00 0.0612 0.6300 0.2470 0.1470 1.110
3.5 3160.00 0.0369 0.7250 0.2540 0.2280 1.220
3.6 3980.00 0.0335 0.7030 0.2620 0.1900 1.220
3.7 5010.00 0.0317 0.6880 0.2700 0.1580 1.220
3.8 6310.00 0.0317 0.6880 0.2700 0.1580 1.220
3.9 7940.00 0.0156 0.5760 0.2810 0.0248 1.130
4.0 10000.00 0.0156 0.5760 0.2810 0.0248 1.130
4.1 12600.00 0.0156 0.5760 0.2810 0.0248 1.130

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 -0.971 0.315 -1.59 -0.3540
0.1 0.6850 1.26 -0.971 0.392 -1.74 -0.2030
0.2 0.6850 1.58 -0.971 0.392 -1.74 -0.2030
0.3 0.6830 2.00 -0.971 0.390 -1.73 -0.2060
0.4 0.6830 2.51 -0.971 0.390 -1.73 -0.2060
0.5 0.6580 3.16 -0.971 0.401 -1.76 -0.1850
0.6 0.6420 3.98 -0.971 0.410 -1.77 -0.1680
0.7 0.6420 5.01 -0.971 0.410 -1.77 -0.1680
0.8 0.6400 6.31 -0.971 0.407 -1.77 -0.1720
0.9 0.6400 7.94 -0.971 0.407 -1.77 -0.1720
1.0 0.6260 10.00 -0.971 0.423 -1.80 -0.1420
1.1 0.6030 12.60 -0.971 0.443 -1.84 -0.1020
1.2 0.6000 15.80 -0.971 0.437 -1.83 -0.1140
1.3 0.5850 20.00 -0.971 0.452 -1.86 -0.0845
1.4 0.5600 25.10 -0.971 0.460 -1.87 -0.0697
1.5 0.5360 31.60 -0.971 0.490 -1.93 -0.0109
1.6 0.4890 39.80 -0.971 0.563 -2.07 0.1330
1.7 0.4860 50.10 -0.971 0.556 -2.06 0.1180
1.8 0.4860 63.10 -0.971 0.556 -2.06 0.1180
1.9 0.4610 79.40 -0.971 0.593 -2.13 0.1920
2.0 0.4260 100.00 -0.971 0.556 -2.06 0.1200
2.1 0.3420 126.00 -0.971 0.602 -2.15 0.2100
2.2 0.3410 158.00 -0.971 0.597 -2.14 0.1990
2.3 0.3370 200.00 -0.971 0.588 -2.12 0.1810
2.4 0.2950 251.00 -0.971 0.699 -2.34 0.4000
2.5 0.2940 316.00 -0.971 0.696 -2.34 0.3940
2.6 0.2550 398.00 -0.971 0.718 -2.38 0.4370
2.7 0.2270 501.00 -0.971 0.939 -2.81 0.8700
2.8 0.1880 631.00 -0.971 1.200 -3.32 1.3800
2.9 0.1370 794.00 -0.971 1.180 -3.29 1.3400
3.0 0.0995 1000.00 -0.971 1.480 -3.87 1.9300
3.1 0.0977 1260.00 -0.971 1.560 -4.04 2.1000
3.2 0.0872 1580.00 -0.971 1.710 -4.33 2.3900
3.3 0.0629 2000.00 -0.971 2.950 -6.75 4.8100
3.4 0.0612 2510.00 -0.971 3.010 -6.87 4.9300
3.5 0.0369 3160.00 -0.971 3.100 -7.04 5.1000
3.6 0.0335 3980.00 -0.971 3.190 -7.23 5.2900
3.7 0.0317 5010.00 -0.971 3.290 -7.43 5.4900
3.8 0.0317 6310.00 -0.971 3.290 -7.43 5.4900
3.9 0.0156 7940.00 -0.971 3.430 -7.68 5.7400
4.0 0.0156 10000.00 -0.971 3.430 -7.68 5.7400
4.1 0.0156 12600.00 -0.971 3.430 -7.68 5.7400

HVTN 505

  • Adjustment covariates: age, racecc, BMI, bhvrisk
  • Event time variable: HIVwk28preunblfu
  • Event type variable: HIVwk28preunbl
  • Weight variable: weight
  • Reference timepoint: 514 days
  • All learners: GLM

IgG V1V2 B.CaseA-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.0913 0.0174 0.057100 0.125
0.1 0.282 1.26 0.0570 0.0238 0.010400 0.104
0.2 0.282 1.58 0.0570 0.0238 0.010400 0.104
0.3 0.282 2.00 0.0570 0.0238 0.010400 0.104
0.4 0.273 2.51 0.0570 0.0248 0.008420 0.106
0.5 0.273 3.16 0.0570 0.0248 0.008420 0.106
0.6 0.273 3.98 0.0570 0.0248 0.008420 0.106
0.7 0.253 5.01 0.0570 0.0258 0.006380 0.108
0.8 0.253 6.31 0.0570 0.0258 0.006380 0.108
0.9 0.253 7.94 0.0570 0.0258 0.006380 0.108
1.0 0.248 10.00 0.0570 0.0271 0.003900 0.110
1.1 0.236 12.60 0.0570 0.0286 0.000932 0.113
1.2 0.236 15.80 0.0570 0.0286 0.000932 0.113
1.3 0.236 20.00 0.0570 0.0286 0.000932 0.113
1.4 0.211 25.10 0.0570 0.0317 -0.005170 0.119
1.5 0.207 31.60 0.0570 0.0332 -0.008050 0.122
1.6 0.207 39.80 0.0570 0.0332 -0.008050 0.122
1.7 0.207 50.10 0.0570 0.0332 -0.008050 0.122
1.8 0.196 63.10 0.0570 0.0349 -0.011500 0.125
1.9 0.182 79.40 0.0570 0.0387 -0.018900 0.133
2.0 0.173 100.00 0.0570 0.0391 -0.019600 0.134
2.1 0.141 126.00 0.0570 0.0455 -0.032100 0.146

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.0913 0.0174 0.049500 0.1220
0.1 1.26 0.282 0.0464 0.0238 -0.000179 0.0930
0.2 1.58 0.282 0.0464 0.0238 -0.000179 0.0930
0.3 2.00 0.282 0.0464 0.0238 -0.000179 0.0930
0.4 2.51 0.273 0.0476 0.0248 -0.000919 0.0962
0.5 3.16 0.273 0.0476 0.0248 -0.000919 0.0962
0.6 3.98 0.273 0.0476 0.0248 -0.000919 0.0962
0.7 5.01 0.253 0.0493 0.0258 -0.001260 0.0999
0.8 6.31 0.253 0.0493 0.0258 -0.001260 0.0999
0.9 7.94 0.253 0.0493 0.0258 -0.001260 0.0999
1.0 10.00 0.248 0.0541 0.0271 0.001060 0.1070
1.1 12.60 0.236 0.0557 0.0286 -0.000311 0.1120
1.2 15.80 0.236 0.0557 0.0286 -0.000311 0.1120
1.3 20.00 0.236 0.0557 0.0286 -0.000311 0.1120
1.4 25.10 0.211 0.0619 0.0317 -0.000237 0.1240
1.5 31.60 0.207 0.0662 0.0332 0.001180 0.1310
1.6 39.80 0.207 0.0662 0.0332 0.001180 0.1310
1.7 50.10 0.207 0.0662 0.0332 0.001180 0.1310
1.8 63.10 0.196 0.0696 0.0349 0.001200 0.1380
1.9 79.40 0.182 0.0689 0.0387 -0.006920 0.1450
2.0 100.00 0.173 0.0700 0.0391 -0.006530 0.1470
2.1 126.00 0.141 0.0758 0.0455 -0.013300 0.1650

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 -0.319 0.387 -1.080 0.439
0.1 0.282 1.26 0.177 0.389 -0.586 0.940
0.2 0.282 1.58 0.177 0.389 -0.586 0.940
0.3 0.282 2.00 0.177 0.389 -0.586 0.940
0.4 0.273 2.51 0.177 0.402 -0.611 0.965
0.5 0.273 3.16 0.177 0.402 -0.611 0.965
0.6 0.273 3.98 0.177 0.402 -0.611 0.965
0.7 0.253 5.01 0.177 0.415 -0.637 0.991
0.8 0.253 6.31 0.177 0.415 -0.637 0.991
0.9 0.253 7.94 0.177 0.415 -0.637 0.991
1.0 0.248 10.00 0.177 0.432 -0.670 1.020
1.1 0.236 12.60 0.177 0.452 -0.709 1.060
1.2 0.236 15.80 0.177 0.452 -0.709 1.060
1.3 0.236 20.00 0.177 0.452 -0.709 1.060
1.4 0.211 25.10 0.177 0.493 -0.790 1.140
1.5 0.207 31.60 0.177 0.513 -0.829 1.180
1.6 0.207 39.80 0.177 0.513 -0.829 1.180
1.7 0.207 50.10 0.177 0.513 -0.829 1.180
1.8 0.196 63.10 0.177 0.537 -0.875 1.230
1.9 0.182 79.40 0.177 0.588 -0.976 1.330
2.0 0.173 100.00 0.177 0.593 -0.986 1.340
2.1 0.141 126.00 0.177 0.682 -1.160 1.510

IgG V1V2 AE.A244-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.0913 0.0174 0.05710 0.125
0.1 0.641 1.26 0.0888 0.0219 0.04580 0.132
0.2 0.633 1.58 0.0888 0.0223 0.04520 0.132
0.3 0.633 2.00 0.0888 0.0223 0.04520 0.132
0.4 0.626 2.51 0.0888 0.0228 0.04410 0.133
0.5 0.626 3.16 0.0888 0.0228 0.04410 0.133
0.6 0.622 3.98 0.0888 0.0232 0.04340 0.134
0.7 0.614 5.01 0.0888 0.0231 0.04350 0.134
0.8 0.594 6.31 0.0888 0.0238 0.04220 0.135
0.9 0.581 7.94 0.0888 0.0247 0.04040 0.137
1.0 0.570 10.00 0.0888 0.0251 0.03960 0.138
1.1 0.558 12.60 0.0888 0.0251 0.03950 0.138
1.2 0.554 15.80 0.0888 0.0254 0.03900 0.139
1.3 0.534 20.00 0.0888 0.0258 0.03820 0.139
1.4 0.502 25.10 0.0888 0.0262 0.03750 0.140
1.5 0.482 31.60 0.0888 0.0264 0.03700 0.141
1.6 0.441 39.80 0.0888 0.0293 0.03130 0.146
1.7 0.430 50.10 0.0888 0.0305 0.02890 0.149
1.8 0.408 63.10 0.0888 0.0316 0.02690 0.151
1.9 0.380 79.40 0.0888 0.0330 0.02410 0.154
2.0 0.355 100.00 0.0888 0.0333 0.02350 0.154
2.1 0.305 126.00 0.0888 0.0356 0.01890 0.159
2.2 0.264 158.00 0.0888 0.0362 0.01780 0.160
2.3 0.237 200.00 0.0846 0.0310 0.02380 0.145
2.4 0.225 251.00 0.0846 0.0336 0.01880 0.150
2.5 0.210 316.00 0.0846 0.0344 0.01710 0.152
2.6 0.178 398.00 0.0846 0.0384 0.00920 0.160
2.7 0.151 501.00 0.0846 0.0473 -0.00821 0.177
2.8 0.139 631.00 0.0846 0.0518 -0.01710 0.186
2.9 0.135 794.00 0.0846 0.0570 -0.02720 0.196
3.0 0.114 1000.00 0.0846 0.0643 -0.04150 0.211
3.1 0.103 1260.00 0.0846 0.0639 -0.04070 0.210

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.0913 0.0174 0.05170 0.125
0.1 1.26 0.641 0.0788 0.0219 0.03580 0.122
0.2 1.58 0.633 0.0800 0.0223 0.03630 0.124
0.3 2.00 0.633 0.0800 0.0223 0.03630 0.124
0.4 2.51 0.626 0.0816 0.0228 0.03700 0.126
0.5 3.16 0.626 0.0816 0.0228 0.03700 0.126
0.6 3.98 0.622 0.0827 0.0232 0.03730 0.128
0.7 5.01 0.614 0.0826 0.0231 0.03720 0.128
0.8 6.31 0.594 0.0848 0.0238 0.03820 0.131
0.9 7.94 0.581 0.0888 0.0247 0.04040 0.137
1.0 10.00 0.570 0.0902 0.0251 0.04100 0.139
1.1 12.60 0.558 0.0902 0.0251 0.04100 0.140
1.2 15.80 0.554 0.0912 0.0254 0.04140 0.141
1.3 20.00 0.534 0.0922 0.0258 0.04150 0.143
1.4 25.10 0.502 0.0898 0.0262 0.03850 0.141
1.5 31.60 0.482 0.0866 0.0264 0.03480 0.138
1.6 39.80 0.441 0.0966 0.0293 0.03910 0.154
1.7 50.10 0.430 0.1010 0.0305 0.04080 0.161
1.8 63.10 0.408 0.0992 0.0316 0.03730 0.161
1.9 79.40 0.380 0.1050 0.0330 0.04000 0.169
2.0 100.00 0.355 0.1070 0.0333 0.04140 0.172
2.1 126.00 0.305 0.1090 0.0356 0.03920 0.179
2.2 158.00 0.264 0.0965 0.0362 0.02540 0.167
2.3 200.00 0.237 0.0633 0.0310 0.00250 0.124
2.4 251.00 0.225 0.0687 0.0336 0.00294 0.135
2.5 316.00 0.210 0.0603 0.0344 -0.00722 0.128
2.6 398.00 0.178 0.0660 0.0384 -0.00940 0.141
2.7 501.00 0.151 0.0864 0.0473 -0.00631 0.179
2.8 631.00 0.139 0.0926 0.0518 -0.00901 0.194
2.9 794.00 0.135 0.1000 0.0570 -0.01140 0.212
3.0 1000.00 0.114 0.1120 0.0643 -0.01430 0.238
3.1 1260.00 0.103 0.1120 0.0639 -0.01360 0.237

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 -0.319 0.387 -1.08 0.439
0.1 0.641 1.26 -0.283 0.427 -1.12 0.553
0.2 0.633 1.58 -0.283 0.430 -1.13 0.560
0.3 0.633 2.00 -0.283 0.430 -1.13 0.560
0.4 0.626 2.51 -0.283 0.436 -1.14 0.571
0.5 0.626 3.16 -0.283 0.436 -1.14 0.571
0.6 0.622 3.98 -0.283 0.440 -1.15 0.579
0.7 0.614 5.01 -0.283 0.440 -1.14 0.578
0.8 0.594 6.31 -0.283 0.447 -1.16 0.592
0.9 0.581 7.94 -0.283 0.457 -1.18 0.613
1.0 0.570 10.00 -0.283 0.461 -1.19 0.621
1.1 0.558 12.60 -0.283 0.462 -1.19 0.622
1.2 0.554 15.80 -0.283 0.465 -1.19 0.628
1.3 0.534 20.00 -0.283 0.470 -1.20 0.638
1.4 0.502 25.10 -0.283 0.474 -1.21 0.645
1.5 0.482 31.60 -0.283 0.477 -1.22 0.651
1.6 0.441 39.80 -0.283 0.511 -1.28 0.719
1.7 0.430 50.10 -0.283 0.526 -1.31 0.747
1.8 0.408 63.10 -0.283 0.538 -1.34 0.772
1.9 0.380 79.40 -0.283 0.556 -1.37 0.806
2.0 0.355 100.00 -0.283 0.560 -1.38 0.814
2.1 0.305 126.00 -0.283 0.589 -1.44 0.871
2.2 0.264 158.00 -0.283 0.596 -1.45 0.886
2.3 0.237 200.00 -0.222 0.524 -1.25 0.805
2.4 0.225 251.00 -0.222 0.556 -1.31 0.868
2.5 0.210 316.00 -0.222 0.567 -1.33 0.890
2.6 0.178 398.00 -0.222 0.618 -1.43 0.990
2.7 0.151 501.00 -0.222 0.736 -1.66 1.220
2.8 0.139 631.00 -0.222 0.797 -1.78 1.340
2.9 0.135 794.00 -0.222 0.867 -1.92 1.480
3.0 0.114 1000.00 -0.222 0.968 -2.12 1.680
3.1 0.103 1260.00 -0.222 0.963 -2.11 1.670

IgG V1V2 C.1086-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.0913 0.0174 0.05710 0.125
0.1 0.672 1.26 0.0840 0.0220 0.04100 0.127
0.2 0.672 1.58 0.0840 0.0220 0.04100 0.127
0.3 0.666 2.00 0.0840 0.0226 0.03970 0.128
0.4 0.666 2.51 0.0840 0.0226 0.03970 0.128
0.5 0.662 3.16 0.0840 0.0232 0.03850 0.129
0.6 0.662 3.98 0.0840 0.0232 0.03850 0.129
0.7 0.653 5.01 0.0840 0.0234 0.03820 0.130
0.8 0.648 6.31 0.0840 0.0241 0.03670 0.131
0.9 0.648 7.94 0.0840 0.0241 0.03670 0.131
1.0 0.618 10.00 0.0840 0.0243 0.03640 0.132
1.1 0.601 12.60 0.0840 0.0253 0.03430 0.134
1.2 0.577 15.80 0.0775 0.0225 0.03330 0.122
1.3 0.541 20.00 0.0775 0.0237 0.03090 0.124
1.4 0.526 25.10 0.0775 0.0243 0.02980 0.125
1.5 0.498 31.60 0.0727 0.0238 0.02610 0.119
1.6 0.494 39.80 0.0656 0.0228 0.02100 0.110
1.7 0.462 50.10 0.0642 0.0218 0.02150 0.107
1.8 0.451 63.10 0.0642 0.0223 0.02060 0.108
1.9 0.408 79.40 0.0642 0.0227 0.01960 0.109
2.0 0.377 100.00 0.0642 0.0204 0.02420 0.104
2.1 0.353 126.00 0.0642 0.0224 0.02030 0.108
2.2 0.330 158.00 0.0642 0.0244 0.01640 0.112
2.3 0.318 200.00 0.0642 0.0273 0.01060 0.118
2.4 0.292 251.00 0.0642 0.0265 0.01210 0.116
2.5 0.276 316.00 0.0642 0.0282 0.00892 0.119
2.6 0.256 398.00 0.0642 0.0291 0.00707 0.121
2.7 0.227 501.00 0.0642 0.0373 -0.00889 0.137

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.0913 0.0174 0.05410 0.1280
0.1 1.26 0.672 0.0788 0.0220 0.03580 0.1220
0.2 1.58 0.672 0.0788 0.0220 0.03580 0.1220
0.3 2.00 0.666 0.0806 0.0226 0.03630 0.1250
0.4 2.51 0.666 0.0806 0.0226 0.03630 0.1250
0.5 3.16 0.662 0.0838 0.0232 0.03830 0.1290
0.6 3.98 0.662 0.0838 0.0232 0.03830 0.1290
0.7 5.01 0.653 0.0844 0.0234 0.03860 0.1300
0.8 6.31 0.648 0.0874 0.0241 0.04010 0.1350
0.9 7.94 0.648 0.0874 0.0241 0.04010 0.1350
1.0 10.00 0.618 0.0882 0.0243 0.04060 0.1360
1.1 12.60 0.601 0.0910 0.0253 0.04130 0.1410
1.2 15.80 0.577 0.0737 0.0225 0.02950 0.1180
1.3 20.00 0.541 0.0784 0.0237 0.03190 0.1250
1.4 25.10 0.526 0.0805 0.0243 0.03290 0.1280
1.5 31.60 0.498 0.0727 0.0238 0.02610 0.1190
1.6 39.80 0.494 0.0656 0.0228 0.02100 0.1100
1.7 50.10 0.462 0.0608 0.0218 0.01820 0.1030
1.8 63.10 0.451 0.0632 0.0223 0.01960 0.1070
1.9 79.40 0.408 0.0630 0.0227 0.01850 0.1080
2.0 100.00 0.377 0.0549 0.0204 0.01500 0.0949
2.1 126.00 0.353 0.0603 0.0224 0.01640 0.1040
2.2 158.00 0.330 0.0648 0.0244 0.01700 0.1130
2.3 200.00 0.318 0.0682 0.0273 0.01460 0.1220
2.4 251.00 0.292 0.0623 0.0265 0.01030 0.1140
2.5 316.00 0.276 0.0660 0.0282 0.01080 0.1210
2.6 398.00 0.256 0.0637 0.0291 0.00663 0.1210
2.7 501.00 0.227 0.0786 0.0373 0.00555 0.1520

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 -0.3190 0.387 -1.080 0.439
0.1 0.672 1.26 -0.2140 0.416 -1.030 0.603
0.2 0.672 1.58 -0.2140 0.416 -1.030 0.603
0.3 0.666 2.00 -0.2140 0.424 -1.040 0.617
0.4 0.666 2.51 -0.2140 0.424 -1.040 0.617
0.5 0.662 3.16 -0.2140 0.430 -1.060 0.630
0.6 0.662 3.98 -0.2140 0.430 -1.060 0.630
0.7 0.653 5.01 -0.2140 0.432 -1.060 0.633
0.8 0.648 6.31 -0.2140 0.441 -1.080 0.650
0.9 0.648 7.94 -0.2140 0.441 -1.080 0.650
1.0 0.618 10.00 -0.2140 0.443 -1.080 0.654
1.1 0.601 12.60 -0.2140 0.455 -1.110 0.678
1.2 0.577 15.80 -0.1190 0.410 -0.923 0.684
1.3 0.541 20.00 -0.1190 0.424 -0.949 0.711
1.4 0.526 25.10 -0.1190 0.430 -0.962 0.724
1.5 0.498 31.60 -0.0498 0.415 -0.863 0.764
1.6 0.494 39.80 0.0516 0.391 -0.714 0.818
1.7 0.462 50.10 0.0727 0.376 -0.664 0.810
1.8 0.451 63.10 0.0727 0.382 -0.676 0.821
1.9 0.408 79.40 0.0727 0.388 -0.687 0.833
2.0 0.377 100.00 0.0727 0.360 -0.632 0.777
2.1 0.353 126.00 0.0727 0.384 -0.680 0.825
2.2 0.330 158.00 0.0727 0.408 -0.728 0.873
2.3 0.318 200.00 0.0727 0.445 -0.800 0.946
2.4 0.292 251.00 0.0727 0.436 -0.781 0.926
2.5 0.276 316.00 0.0727 0.457 -0.822 0.968
2.6 0.256 398.00 0.0727 0.469 -0.846 0.992
2.7 0.227 501.00 0.0727 0.577 -1.060 1.200

IgG V1V2 C.1086-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.0913 0.0174 0.057100 0.1250
0.1 0.411 1.26 0.0530 0.0232 0.007610 0.0985
0.2 0.411 1.58 0.0530 0.0232 0.007610 0.0985
0.3 0.411 2.00 0.0530 0.0232 0.007610 0.0985
0.4 0.399 2.51 0.0530 0.0235 0.007000 0.0991
0.5 0.387 3.16 0.0530 0.0240 0.005930 0.1000
0.6 0.387 3.98 0.0530 0.0240 0.005930 0.1000
0.7 0.379 5.01 0.0530 0.0238 0.006340 0.0998
0.8 0.374 6.31 0.0530 0.0245 0.005000 0.1010
0.9 0.374 7.94 0.0530 0.0245 0.005000 0.1010
1.0 0.353 10.00 0.0530 0.0248 0.004360 0.1020
1.1 0.345 12.60 0.0530 0.0250 0.004010 0.1020
1.2 0.336 15.80 0.0530 0.0252 0.003740 0.1020
1.3 0.328 20.00 0.0530 0.0257 0.002770 0.1030
1.4 0.320 25.10 0.0510 0.0225 0.006780 0.0952
1.5 0.296 31.60 0.0510 0.0234 0.005180 0.0968
1.6 0.291 39.80 0.0510 0.0248 0.002460 0.0995
1.7 0.291 50.10 0.0510 0.0248 0.002460 0.0995
1.8 0.280 63.10 0.0510 0.0257 0.000605 0.1010
1.9 0.275 79.40 0.0510 0.0265 -0.000994 0.1030
2.0 0.258 100.00 0.0510 0.0277 -0.003390 0.1050
2.1 0.252 126.00 0.0510 0.0296 -0.007020 0.1090

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.0913 0.0174 0.049500 0.1220
0.1 1.26 0.411 0.0510 0.0232 0.005520 0.0964
0.2 1.58 0.411 0.0510 0.0232 0.005520 0.0964
0.3 2.00 0.411 0.0510 0.0232 0.005520 0.0964
0.4 2.51 0.399 0.0516 0.0235 0.005510 0.0976
0.5 3.16 0.387 0.0524 0.0240 0.005280 0.0995
0.6 3.98 0.387 0.0524 0.0240 0.005280 0.0995
0.7 5.01 0.379 0.0522 0.0238 0.005480 0.0989
0.8 6.31 0.374 0.0540 0.0245 0.005970 0.1020
0.9 7.94 0.374 0.0540 0.0245 0.005970 0.1020
1.0 10.00 0.353 0.0546 0.0248 0.005910 0.1030
1.1 12.60 0.345 0.0549 0.0250 0.005860 0.1040
1.2 15.80 0.336 0.0550 0.0252 0.005730 0.1040
1.3 20.00 0.328 0.0557 0.0257 0.005370 0.1060
1.4 25.10 0.320 0.0438 0.0225 -0.000362 0.0880
1.5 31.60 0.296 0.0452 0.0234 -0.000624 0.0910
1.6 39.80 0.291 0.0500 0.0248 0.001540 0.0986
1.7 50.10 0.291 0.0500 0.0248 0.001540 0.0986
1.8 63.10 0.280 0.0517 0.0257 0.001360 0.1020
1.9 79.40 0.275 0.0531 0.0265 0.001150 0.1050
2.0 100.00 0.258 0.0550 0.0277 0.000610 0.1090
2.1 126.00 0.252 0.0589 0.0296 0.000881 0.1170

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 -0.319 0.387 -1.080 0.439
0.1 0.411 1.26 0.234 0.376 -0.503 0.970
0.2 0.411 1.58 0.234 0.376 -0.503 0.970
0.3 0.411 2.00 0.234 0.376 -0.503 0.970
0.4 0.399 2.51 0.234 0.380 -0.511 0.978
0.5 0.387 3.16 0.234 0.387 -0.525 0.992
0.6 0.387 3.98 0.234 0.387 -0.525 0.992
0.7 0.379 5.01 0.234 0.384 -0.520 0.987
0.8 0.374 6.31 0.234 0.393 -0.537 1.000
0.9 0.374 7.94 0.234 0.393 -0.537 1.000
1.0 0.353 10.00 0.234 0.397 -0.545 1.010
1.1 0.345 12.60 0.234 0.400 -0.550 1.020
1.2 0.336 15.80 0.234 0.402 -0.553 1.020
1.3 0.328 20.00 0.234 0.408 -0.566 1.030
1.4 0.320 25.10 0.263 0.365 -0.451 0.978
1.5 0.296 31.60 0.263 0.375 -0.472 0.999
1.6 0.291 39.80 0.263 0.393 -0.507 1.030
1.7 0.291 50.10 0.263 0.393 -0.507 1.030
1.8 0.280 63.10 0.263 0.406 -0.532 1.060
1.9 0.275 79.40 0.263 0.417 -0.553 1.080
2.0 0.258 100.00 0.263 0.433 -0.585 1.110
2.1 0.252 126.00 0.263 0.458 -0.634 1.160

IgG3 V1V2 B.CaseA-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.0913 0.0174 0.05710 0.125
0.1 0.546 1.26 0.0811 0.0238 0.03450 0.128
0.2 0.514 1.58 0.0793 0.0223 0.03560 0.123
0.3 0.514 2.00 0.0793 0.0223 0.03560 0.123
0.4 0.446 2.51 0.0793 0.0253 0.02970 0.129
0.5 0.414 3.16 0.0793 0.0266 0.02710 0.132
0.6 0.375 3.98 0.0793 0.0298 0.02090 0.138
0.7 0.319 5.01 0.0793 0.0361 0.00854 0.150
0.8 0.306 6.31 0.0793 0.0385 0.00378 0.155
0.9 0.279 7.94 0.0793 0.0427 -0.00446 0.163
1.0 0.232 10.00 0.0793 0.0449 -0.00868 0.167
1.1 0.190 12.60 0.0793 0.0500 -0.01860 0.177
1.2 0.178 15.80 0.0793 0.0485 -0.01580 0.174
1.3 0.164 20.00 0.0793 0.0521 -0.02280 0.181
1.4 0.164 25.10 0.0793 0.0521 -0.02280 0.181
1.5 0.144 31.60 0.0793 0.0473 -0.01340 0.172

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.0913 0.0174 0.057400 0.133
0.1 1.26 0.546 0.0811 0.0238 0.034500 0.128
0.2 1.58 0.514 0.0732 0.0223 0.029400 0.117
0.3 2.00 0.514 0.0732 0.0223 0.029400 0.117
0.4 2.51 0.446 0.0783 0.0253 0.028600 0.128
0.5 3.16 0.414 0.0827 0.0266 0.030500 0.135
0.6 3.98 0.375 0.0907 0.0298 0.032200 0.149
0.7 5.01 0.319 0.1050 0.0361 0.034200 0.176
0.8 6.31 0.306 0.1120 0.0385 0.036000 0.187
0.9 7.94 0.279 0.1200 0.0427 0.036400 0.204
1.0 10.00 0.232 0.0954 0.0449 0.007410 0.183
1.1 12.60 0.190 0.1090 0.0500 0.011500 0.207
1.2 15.80 0.178 0.1090 0.0485 0.014000 0.204
1.3 20.00 0.164 0.1100 0.0521 0.007590 0.212
1.4 25.10 0.164 0.1100 0.0521 0.007590 0.212
1.5 31.60 0.144 0.0921 0.0473 -0.000628 0.185

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 -0.319 0.387 -1.080 0.439
0.1 0.546 1.26 -0.172 0.432 -1.020 0.674
0.2 0.514 1.58 -0.146 0.411 -0.952 0.660
0.3 0.514 2.00 -0.146 0.411 -0.952 0.660
0.4 0.446 2.51 -0.146 0.446 -1.020 0.728
0.5 0.414 3.16 -0.146 0.462 -1.050 0.759
0.6 0.375 3.98 -0.146 0.501 -1.130 0.835
0.7 0.319 5.01 -0.146 0.581 -1.280 0.992
0.8 0.306 6.31 -0.146 0.612 -1.350 1.050
0.9 0.279 7.94 -0.146 0.668 -1.460 1.160
1.0 0.232 10.00 -0.146 0.697 -1.510 1.220
1.1 0.190 12.60 -0.146 0.765 -1.650 1.350
1.2 0.178 15.80 -0.146 0.746 -1.610 1.320
1.3 0.164 20.00 -0.146 0.795 -1.700 1.410
1.4 0.164 25.10 -0.146 0.795 -1.700 1.410
1.5 0.144 31.60 -0.146 0.730 -1.580 1.280

IgG3 V1V2 AE.A244-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.0954 0.0174 0.06120 0.130
0.1 0.7520 1.26 0.0954 0.0215 0.05320 0.138
0.2 0.7340 1.58 0.0954 0.0212 0.05390 0.137
0.3 0.7160 2.00 0.0954 0.0218 0.05260 0.138
0.4 0.6720 2.51 0.0954 0.0223 0.05180 0.139
0.5 0.6570 3.16 0.0954 0.0231 0.05020 0.141
0.6 0.5980 3.98 0.0954 0.0244 0.04760 0.143
0.7 0.5530 5.01 0.0954 0.0258 0.04490 0.146
0.8 0.4920 6.31 0.0954 0.0294 0.03780 0.153
0.9 0.4360 7.94 0.0954 0.0348 0.02720 0.164
1.0 0.4060 10.00 0.0954 0.0380 0.02080 0.170
1.1 0.3560 12.60 0.0954 0.0351 0.02650 0.164
1.2 0.3200 15.80 0.0954 0.0393 0.01840 0.172
1.3 0.3120 20.00 0.0954 0.0371 0.02270 0.168
1.4 0.2610 25.10 0.0954 0.0322 0.03230 0.159
1.5 0.2500 31.60 0.0954 0.0330 0.03080 0.160
1.6 0.2100 39.80 0.0954 0.0399 0.01720 0.174
1.7 0.1680 50.10 0.0954 0.0509 -0.00436 0.195
1.8 0.1680 63.10 0.0954 0.0509 -0.00436 0.195
1.9 0.1260 79.40 0.0954 0.0668 -0.03550 0.226
2.0 0.1150 100.00 0.0954 0.0791 -0.05970 0.251
2.1 0.1110 126.00 0.0954 0.0813 -0.06390 0.255
2.2 0.0909 158.00 0.0954 0.0826 -0.06650 0.257
2.3 0.0796 200.00 0.0954 0.0842 -0.06970 0.261
2.4 0.0796 251.00 0.0954 0.0842 -0.06970 0.261

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.0913 0.0174 0.0560 0.130
0.1 1.26 0.7520 0.0872 0.0215 0.0450 0.129
0.2 1.58 0.7340 0.0838 0.0212 0.0423 0.125
0.3 2.00 0.7160 0.0856 0.0218 0.0428 0.128
0.4 2.51 0.6720 0.0827 0.0223 0.0391 0.126
0.5 3.16 0.6570 0.0851 0.0231 0.0400 0.130
0.6 3.98 0.5980 0.0877 0.0244 0.0400 0.136
0.7 5.01 0.5530 0.0932 0.0258 0.0428 0.144
0.8 6.31 0.4920 0.1080 0.0294 0.0501 0.165
0.9 7.94 0.4360 0.1280 0.0348 0.0601 0.196
1.0 10.00 0.4060 0.1330 0.0380 0.0586 0.208
1.1 12.60 0.3560 0.0948 0.0351 0.0259 0.164
1.2 15.80 0.3200 0.0986 0.0393 0.0215 0.176
1.3 20.00 0.3120 0.0995 0.0371 0.0268 0.172
1.4 25.10 0.2610 0.0878 0.0322 0.0246 0.151
1.5 31.60 0.2500 0.0861 0.0330 0.0215 0.151
1.6 39.80 0.2100 0.1080 0.0399 0.0301 0.186
1.7 50.10 0.1680 0.1420 0.0509 0.0421 0.242
1.8 63.10 0.1680 0.1420 0.0509 0.0421 0.242
1.9 79.40 0.1260 0.1780 0.0668 0.0472 0.309
2.0 100.00 0.1150 0.2070 0.0791 0.0521 0.362
2.1 126.00 0.1110 0.1910 0.0813 0.0313 0.350
2.2 158.00 0.0909 0.1930 0.0826 0.0311 0.355
2.3 200.00 0.0796 0.2870 0.0842 0.1220 0.452
2.4 251.00 0.0796 0.2870 0.0842 0.1220 0.452

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 -0.378 0.397 -1.16 0.400
0.1 0.7520 1.26 -0.378 0.436 -1.23 0.477
0.2 0.7340 1.58 -0.378 0.433 -1.23 0.470
0.3 0.7160 2.00 -0.378 0.440 -1.24 0.484
0.4 0.6720 2.51 -0.378 0.444 -1.25 0.492
0.5 0.6570 3.16 -0.378 0.453 -1.27 0.509
0.6 0.5980 3.98 -0.378 0.467 -1.29 0.537
0.7 0.5530 5.01 -0.378 0.482 -1.32 0.567
0.8 0.4920 6.31 -0.378 0.524 -1.40 0.648
0.9 0.4360 7.94 -0.378 0.589 -1.53 0.776
1.0 0.4060 10.00 -0.378 0.629 -1.61 0.855
1.1 0.3560 12.60 -0.378 0.593 -1.54 0.784
1.2 0.3200 15.80 -0.378 0.645 -1.64 0.886
1.3 0.3120 20.00 -0.378 0.617 -1.59 0.832
1.4 0.2610 25.10 -0.378 0.557 -1.47 0.714
1.5 0.2500 31.60 -0.378 0.566 -1.49 0.732
1.6 0.2100 39.80 -0.378 0.653 -1.66 0.902
1.7 0.1680 50.10 -0.378 0.797 -1.94 1.180
1.8 0.1680 63.10 -0.378 0.797 -1.94 1.180
1.9 0.1260 79.40 -0.378 1.010 -2.36 1.610
2.0 0.1150 100.00 -0.378 1.180 -2.70 1.940
2.1 0.1110 126.00 -0.378 1.210 -2.76 2.000
2.2 0.0909 158.00 -0.378 1.230 -2.79 2.040
2.3 0.0796 200.00 -0.378 1.260 -2.84 2.080
2.4 0.0796 251.00 -0.378 1.260 -2.84 2.080

IgG3 V1V2 C.1086-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.1 0.0174 0.06590 0.134
0.1 0.7520 1.26 0.1 0.0205 0.05990 0.140
0.2 0.7200 1.58 0.1 0.0211 0.05870 0.141
0.3 0.6780 2.00 0.1 0.0217 0.05760 0.143
0.4 0.6480 2.51 0.1 0.0230 0.05500 0.145
0.5 0.6480 3.16 0.1 0.0230 0.05500 0.145
0.6 0.6140 3.98 0.1 0.0247 0.05170 0.148
0.7 0.5680 5.01 0.1 0.0260 0.04920 0.151
0.8 0.5020 6.31 0.1 0.0282 0.04470 0.155
0.9 0.4600 7.94 0.1 0.0340 0.03340 0.167
1.0 0.4210 10.00 0.1 0.0272 0.04680 0.153
1.1 0.3980 12.60 0.1 0.0297 0.04180 0.158
1.2 0.3790 15.80 0.1 0.0311 0.03910 0.161
1.3 0.3310 20.00 0.1 0.0371 0.02730 0.173
1.4 0.2890 25.10 0.1 0.0383 0.02490 0.175
1.5 0.2730 31.60 0.1 0.0419 0.01790 0.182
1.6 0.2620 39.80 0.1 0.0446 0.01260 0.188
1.7 0.2430 50.10 0.1 0.0471 0.00773 0.192
1.8 0.1850 63.10 0.1 0.0460 0.00998 0.190
1.9 0.1630 79.40 0.1 0.0500 0.00201 0.198
2.0 0.1630 100.00 0.1 0.0500 0.00201 0.198
2.1 0.1360 126.00 0.1 0.0549 -0.00749 0.208
2.2 0.1360 158.00 0.1 0.0549 -0.00749 0.208
2.3 0.1210 200.00 0.1 0.0551 -0.00796 0.208
2.4 0.0843 251.00 0.1 0.0940 -0.08430 0.284
2.5 0.0843 316.00 0.1 0.0940 -0.08430 0.284
2.6 0.0765 398.00 0.1 0.0951 -0.08640 0.287

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.0913 0.0174 0.05600 0.130
0.1 1.26 0.7520 0.0841 0.0205 0.04390 0.124
0.2 1.58 0.7200 0.0862 0.0211 0.04490 0.128
0.3 2.00 0.6780 0.0844 0.0217 0.04200 0.127
0.4 2.51 0.6480 0.0898 0.0230 0.04470 0.135
0.5 3.16 0.6480 0.0898 0.0230 0.04470 0.135
0.6 3.98 0.6140 0.0979 0.0247 0.04950 0.146
0.7 5.01 0.5680 0.0981 0.0260 0.04720 0.149
0.8 6.31 0.5020 0.0984 0.0282 0.04300 0.154
0.9 7.94 0.4600 0.1160 0.0340 0.04950 0.183
1.0 10.00 0.4210 0.0855 0.0272 0.03230 0.139
1.1 12.60 0.3980 0.0902 0.0297 0.03200 0.149
1.2 15.80 0.3790 0.0977 0.0311 0.03680 0.159
1.3 20.00 0.3310 0.1220 0.0371 0.04890 0.194
1.4 25.10 0.2890 0.1190 0.0383 0.04390 0.194
1.5 31.60 0.2730 0.1240 0.0419 0.04140 0.206
1.6 39.80 0.2620 0.1310 0.0446 0.04360 0.219
1.7 50.10 0.2430 0.1430 0.0471 0.05080 0.235
1.8 63.10 0.1850 0.1090 0.0460 0.01900 0.199
1.9 79.40 0.1630 0.1050 0.0500 0.00646 0.203
2.0 100.00 0.1630 0.1050 0.0500 0.00646 0.203
2.1 126.00 0.1360 0.1660 0.0549 0.05810 0.273
2.2 158.00 0.1360 0.1660 0.0549 0.05810 0.273
2.3 200.00 0.1210 0.1630 0.0551 0.05530 0.271
2.4 251.00 0.0843 0.2040 0.0940 0.01940 0.388
2.5 316.00 0.0843 0.2040 0.0940 0.01940 0.388
2.6 398.00 0.0765 0.2190 0.0951 0.03280 0.406

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 -0.446 0.409 -1.25 0.355
0.1 0.7520 1.26 -0.446 0.437 -1.30 0.411
0.2 0.7200 1.58 -0.446 0.443 -1.31 0.423
0.3 0.6780 2.00 -0.446 0.449 -1.33 0.434
0.4 0.6480 2.51 -0.446 0.463 -1.35 0.461
0.5 0.6480 3.16 -0.446 0.463 -1.35 0.461
0.6 0.6140 3.98 -0.446 0.480 -1.39 0.495
0.7 0.5680 5.01 -0.446 0.494 -1.41 0.523
0.8 0.5020 6.31 -0.446 0.519 -1.46 0.572
0.9 0.4600 7.94 -0.446 0.587 -1.60 0.705
1.0 0.4210 10.00 -0.446 0.507 -1.44 0.549
1.1 0.3980 12.60 -0.446 0.537 -1.50 0.606
1.2 0.3790 15.80 -0.446 0.552 -1.53 0.637
1.3 0.3310 20.00 -0.446 0.625 -1.67 0.779
1.4 0.2890 25.10 -0.446 0.640 -1.70 0.809
1.5 0.2730 31.60 -0.446 0.685 -1.79 0.898
1.6 0.2620 39.80 -0.446 0.721 -1.86 0.967
1.7 0.2430 50.10 -0.446 0.753 -1.92 1.030
1.8 0.1850 63.10 -0.446 0.738 -1.89 1.000
1.9 0.1630 79.40 -0.446 0.791 -2.00 1.100
2.0 0.1630 100.00 -0.446 0.791 -2.00 1.100
2.1 0.1360 126.00 -0.446 0.856 -2.12 1.230
2.2 0.1360 158.00 -0.446 0.856 -2.12 1.230
2.3 0.1210 200.00 -0.446 0.859 -2.13 1.240
2.4 0.0843 251.00 -0.446 1.400 -3.18 2.290
2.5 0.0843 316.00 -0.446 1.400 -3.18 2.290
2.6 0.0765 398.00 -0.446 1.410 -3.21 2.320

IgG3 V1V2 C.1086-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.0913 0.0174 0.05710 0.125
0.1 0.740 1.26 0.0848 0.0213 0.04310 0.127
0.2 0.732 1.58 0.0848 0.0216 0.04250 0.127
0.3 0.722 2.00 0.0829 0.0215 0.04090 0.125
0.4 0.666 2.51 0.0829 0.0224 0.03900 0.127
0.5 0.666 3.16 0.0829 0.0224 0.03900 0.127
0.6 0.628 3.98 0.0829 0.0231 0.03770 0.128
0.7 0.571 5.01 0.0712 0.0213 0.02940 0.113
0.8 0.528 6.31 0.0712 0.0225 0.02710 0.115
0.9 0.472 7.94 0.0712 0.0251 0.02200 0.120
1.0 0.387 10.00 0.0712 0.0276 0.01710 0.125
1.1 0.347 12.60 0.0712 0.0285 0.01530 0.127
1.2 0.319 15.80 0.0712 0.0320 0.00858 0.134
1.3 0.259 20.00 0.0712 0.0352 0.00223 0.140
1.4 0.241 25.10 0.0712 0.0389 -0.00494 0.147
1.5 0.195 31.60 0.0712 0.0605 -0.04730 0.190
1.6 0.156 39.80 0.0712 0.0402 -0.00761 0.150
1.7 0.147 50.10 0.0712 0.0406 -0.00833 0.151
1.8 0.132 63.10 0.0712 0.0493 -0.02540 0.168
1.9 0.128 79.40 0.0712 0.0469 -0.02060 0.163

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.0913 0.0174 0.05740 0.133
0.1 1.26 0.740 0.0844 0.0213 0.04260 0.126
0.2 1.58 0.732 0.0853 0.0216 0.04300 0.128
0.3 2.00 0.722 0.0821 0.0215 0.04000 0.124
0.4 2.51 0.666 0.0822 0.0224 0.03820 0.126
0.5 3.16 0.666 0.0822 0.0224 0.03820 0.126
0.6 3.98 0.628 0.0853 0.0231 0.04000 0.131
0.7 5.01 0.571 0.0662 0.0213 0.02440 0.108
0.8 6.31 0.528 0.0703 0.0225 0.02610 0.114
0.9 7.94 0.472 0.0774 0.0251 0.02820 0.127
1.0 10.00 0.387 0.0831 0.0276 0.02890 0.137
1.1 12.60 0.347 0.0801 0.0285 0.02410 0.136
1.2 15.80 0.319 0.0896 0.0320 0.02690 0.152
1.3 20.00 0.259 0.0916 0.0352 0.02260 0.161
1.4 25.10 0.241 0.1040 0.0389 0.02740 0.180
1.5 31.60 0.195 0.1450 0.0605 0.02600 0.263
1.6 39.80 0.156 0.0897 0.0402 0.01090 0.169
1.7 50.10 0.147 0.0851 0.0406 0.00557 0.165
1.8 63.10 0.132 0.1010 0.0493 0.00406 0.197
1.9 79.40 0.128 0.0871 0.0469 -0.00473 0.179

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 -0.3190 0.387 -1.080 0.439
0.1 0.740 1.26 -0.2260 0.411 -1.030 0.580
0.2 0.732 1.58 -0.2260 0.414 -1.040 0.586
0.3 0.722 2.00 -0.1990 0.409 -1.000 0.603
0.4 0.666 2.51 -0.1990 0.420 -1.020 0.624
0.5 0.666 3.16 -0.1990 0.420 -1.020 0.624
0.6 0.628 3.98 -0.1990 0.427 -1.040 0.639
0.7 0.571 5.01 -0.0295 0.384 -0.782 0.723
0.8 0.528 6.31 -0.0295 0.398 -0.810 0.751
0.9 0.472 7.94 -0.0295 0.429 -0.870 0.811
1.0 0.387 10.00 -0.0295 0.460 -0.932 0.873
1.1 0.347 12.60 -0.0295 0.472 -0.954 0.895
1.2 0.319 15.80 -0.0295 0.516 -1.040 0.981
1.3 0.259 20.00 -0.0295 0.558 -1.120 1.060
1.4 0.241 25.10 -0.0295 0.607 -1.220 1.160
1.5 0.195 31.60 -0.0295 0.903 -1.800 1.740
1.6 0.156 39.80 -0.0295 0.625 -1.250 1.200
1.7 0.147 50.10 -0.0295 0.630 -1.260 1.200
1.8 0.132 63.10 -0.0295 0.748 -1.500 1.440
1.9 0.128 79.40 -0.0295 0.715 -1.430 1.370

RV144 (24 month)

  • Adjustment covariates: dem_sex, BRA_risk
  • Event time variable: HIVwk26fu
  • Event type variable: HIVwk26
  • Weight variable: sample_weight
  • Reference timepoint: 459 days
  • All learners: GLM

IgG V1V2 B.CaseA-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00361 0.000724 0.002190 0.00503
0.1 0.995 1.26 0.00349 0.000758 0.002000 0.00497
0.2 0.995 1.58 0.00349 0.000758 0.002000 0.00497
0.3 0.995 2.00 0.00349 0.000758 0.002000 0.00497
0.4 0.994 2.51 0.00349 0.000758 0.002000 0.00497
0.5 0.994 3.16 0.00349 0.000758 0.002000 0.00497
0.6 0.994 3.98 0.00349 0.000758 0.002000 0.00497
0.7 0.994 5.01 0.00349 0.000758 0.002000 0.00497
0.8 0.992 6.31 0.00349 0.000759 0.002000 0.00498
0.9 0.992 7.94 0.00349 0.000759 0.002000 0.00498
1.0 0.989 10.00 0.00349 0.000760 0.002000 0.00498
1.1 0.988 12.60 0.00349 0.000761 0.002000 0.00498
1.2 0.982 15.80 0.00349 0.000766 0.001990 0.00499
1.3 0.974 20.00 0.00349 0.000770 0.001980 0.00500
1.4 0.972 25.10 0.00341 0.000754 0.001940 0.00489
1.5 0.967 31.60 0.00341 0.000757 0.001930 0.00490
1.6 0.959 39.80 0.00341 0.000763 0.001920 0.00491
1.7 0.955 50.10 0.00331 0.000748 0.001840 0.00477
1.8 0.934 63.10 0.00322 0.000747 0.001760 0.00469
1.9 0.933 79.40 0.00309 0.000729 0.001670 0.00452
2.0 0.920 100.00 0.00309 0.000737 0.001650 0.00454
2.1 0.907 126.00 0.00299 0.000726 0.001570 0.00442
2.2 0.882 158.00 0.00291 0.000724 0.001490 0.00433
2.3 0.828 200.00 0.00271 0.000716 0.001310 0.00411
2.4 0.790 251.00 0.00271 0.000733 0.001270 0.00415
2.5 0.731 316.00 0.00271 0.000771 0.001200 0.00422
2.6 0.674 398.00 0.00233 0.000741 0.000882 0.00379
2.7 0.617 501.00 0.00229 0.000764 0.000790 0.00379
2.8 0.522 631.00 0.00229 0.000842 0.000637 0.00394
2.9 0.487 794.00 0.00229 0.000918 0.000488 0.00409
3.0 0.411 1000.00 0.00229 0.001110 0.000116 0.00446
3.1 0.351 1260.00 0.00229 0.001250 -0.000163 0.00474
3.2 0.280 1580.00 0.00229 0.001440 -0.000532 0.00511
3.3 0.206 2000.00 0.00229 0.001740 -0.001130 0.00570
3.4 0.165 2510.00 0.00229 0.001450 -0.000557 0.00513

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 0.002100 0.00513
0.1 1.26 0.995 0.00348 0.000758 0.001990 0.00496
0.2 1.58 0.995 0.00348 0.000758 0.001990 0.00496
0.3 2.00 0.995 0.00348 0.000758 0.001990 0.00496
0.4 2.51 0.994 0.00348 0.000758 0.001990 0.00497
0.5 3.16 0.994 0.00348 0.000758 0.001990 0.00497
0.6 3.98 0.994 0.00348 0.000758 0.001990 0.00497
0.7 5.01 0.994 0.00348 0.000758 0.001990 0.00497
0.8 6.31 0.992 0.00348 0.000759 0.001990 0.00497
0.9 7.94 0.992 0.00348 0.000759 0.001990 0.00497
1.0 10.00 0.989 0.00349 0.000760 0.002000 0.00498
1.1 12.60 0.988 0.00349 0.000761 0.002000 0.00498
1.2 15.80 0.982 0.00351 0.000766 0.002010 0.00501
1.3 20.00 0.974 0.00354 0.000770 0.002030 0.00505
1.4 25.10 0.972 0.00340 0.000754 0.001920 0.00487
1.5 31.60 0.967 0.00341 0.000757 0.001920 0.00489
1.6 39.80 0.959 0.00344 0.000763 0.001940 0.00494
1.7 50.10 0.955 0.00331 0.000748 0.001840 0.00477
1.8 63.10 0.934 0.00322 0.000747 0.001760 0.00469
1.9 79.40 0.933 0.00308 0.000729 0.001650 0.00451
2.0 100.00 0.920 0.00311 0.000737 0.001670 0.00455
2.1 126.00 0.907 0.00299 0.000726 0.001570 0.00442
2.2 158.00 0.882 0.00291 0.000724 0.001490 0.00433
2.3 200.00 0.828 0.00271 0.000716 0.001310 0.00411
2.4 251.00 0.790 0.00269 0.000733 0.001250 0.00413
2.5 316.00 0.731 0.00273 0.000771 0.001220 0.00424
2.6 398.00 0.674 0.00233 0.000741 0.000882 0.00379
2.7 501.00 0.617 0.00228 0.000764 0.000787 0.00378
2.8 631.00 0.522 0.00239 0.000842 0.000738 0.00404
2.9 794.00 0.487 0.00260 0.000918 0.000804 0.00440
3.0 1000.00 0.411 0.00290 0.001110 0.000729 0.00507
3.1 1260.00 0.351 0.00322 0.001250 0.000774 0.00567
3.2 1580.00 0.280 0.00321 0.001440 0.000391 0.00603
3.3 2000.00 0.206 0.00301 0.001740 -0.000402 0.00643
3.4 2510.00 0.165 0.00239 0.001450 -0.000459 0.00523

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.220 0.214 -0.19900 0.638
0.1 0.995 1.26 0.246 0.216 -0.17600 0.669
0.2 0.995 1.58 0.246 0.216 -0.17600 0.669
0.3 0.995 2.00 0.246 0.216 -0.17600 0.669
0.4 0.994 2.51 0.246 0.216 -0.17700 0.669
0.5 0.994 3.16 0.246 0.216 -0.17700 0.669
0.6 0.994 3.98 0.246 0.216 -0.17700 0.669
0.7 0.994 5.01 0.246 0.216 -0.17700 0.669
0.8 0.992 6.31 0.246 0.216 -0.17700 0.669
0.9 0.992 7.94 0.246 0.216 -0.17700 0.669
1.0 0.989 10.00 0.246 0.216 -0.17700 0.670
1.1 0.988 12.60 0.246 0.216 -0.17800 0.670
1.2 0.982 15.80 0.246 0.217 -0.17900 0.672
1.3 0.974 20.00 0.246 0.218 -0.18100 0.673
1.4 0.972 25.10 0.262 0.213 -0.15600 0.680
1.5 0.967 31.60 0.262 0.214 -0.15700 0.681
1.6 0.959 39.80 0.262 0.215 -0.15900 0.683
1.7 0.955 50.10 0.286 0.209 -0.12500 0.696
1.8 0.934 63.10 0.303 0.207 -0.10300 0.709
1.9 0.933 79.40 0.331 0.201 -0.06200 0.725
2.0 0.920 100.00 0.331 0.202 -0.06470 0.728
2.1 0.907 126.00 0.353 0.198 -0.03440 0.741
2.2 0.882 158.00 0.372 0.195 -0.01120 0.755
2.3 0.828 200.00 0.415 0.189 0.04370 0.785
2.4 0.790 251.00 0.415 0.192 0.03770 0.791
2.5 0.731 316.00 0.415 0.199 0.02440 0.805
2.6 0.674 398.00 0.496 0.186 0.13200 0.859
2.7 0.617 501.00 0.506 0.189 0.13500 0.876
2.8 0.522 631.00 0.506 0.204 0.10600 0.905
2.9 0.487 794.00 0.506 0.219 0.07680 0.934
3.0 0.411 1000.00 0.506 0.257 0.00264 1.010
3.1 0.351 1260.00 0.506 0.285 -0.05390 1.070
3.2 0.280 1580.00 0.506 0.324 -0.13000 1.140
3.3 0.206 2000.00 0.506 0.388 -0.25400 1.270
3.4 0.165 2510.00 0.506 0.327 -0.13500 1.150

IgG V1V2 AE.A244-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00362 0.000724 0.002200 0.00504
0.1 0.995 1.26 0.00362 0.000775 0.002100 0.00514
0.2 0.995 1.58 0.00362 0.000775 0.002100 0.00514
0.3 0.995 2.00 0.00362 0.000775 0.002100 0.00514
0.4 0.995 2.51 0.00362 0.000775 0.002100 0.00514
0.5 0.995 3.16 0.00362 0.000775 0.002100 0.00514
0.6 0.995 3.98 0.00362 0.000775 0.002100 0.00514
0.7 0.994 5.01 0.00362 0.000776 0.002100 0.00514
0.8 0.992 6.31 0.00362 0.000776 0.002100 0.00514
0.9 0.992 7.94 0.00349 0.000759 0.002000 0.00498
1.0 0.992 10.00 0.00349 0.000759 0.002000 0.00498
1.1 0.992 12.60 0.00349 0.000759 0.002000 0.00498
1.2 0.992 15.80 0.00349 0.000759 0.002000 0.00498
1.3 0.992 20.00 0.00349 0.000759 0.002000 0.00498
1.4 0.992 25.10 0.00349 0.000759 0.002000 0.00498
1.5 0.992 31.60 0.00349 0.000759 0.002000 0.00498
1.6 0.992 39.80 0.00349 0.000759 0.002000 0.00498
1.7 0.992 50.10 0.00349 0.000759 0.002000 0.00498
1.8 0.991 63.10 0.00349 0.000760 0.002000 0.00498
1.9 0.991 79.40 0.00349 0.000760 0.002000 0.00498
2.0 0.991 100.00 0.00349 0.000760 0.002000 0.00498
2.1 0.989 126.00 0.00349 0.000760 0.002000 0.00498
2.2 0.988 158.00 0.00349 0.000761 0.002000 0.00498
2.3 0.988 200.00 0.00349 0.000761 0.002000 0.00498
2.4 0.988 251.00 0.00349 0.000761 0.002000 0.00498
2.5 0.986 316.00 0.00349 0.000763 0.001990 0.00498
2.6 0.986 398.00 0.00349 0.000763 0.001990 0.00498
2.7 0.981 501.00 0.00349 0.000765 0.001990 0.00499
2.8 0.981 631.00 0.00337 0.000748 0.001900 0.00483
2.9 0.981 794.00 0.00337 0.000748 0.001900 0.00483
3.0 0.981 1000.00 0.00337 0.000748 0.001900 0.00483
3.1 0.979 1260.00 0.00328 0.000731 0.001850 0.00472
3.2 0.967 1580.00 0.00328 0.000743 0.001830 0.00474
3.3 0.958 2000.00 0.00328 0.000749 0.001810 0.00475
3.4 0.957 2510.00 0.00328 0.000751 0.001810 0.00475
3.5 0.944 3160.00 0.00319 0.000739 0.001750 0.00464
3.6 0.924 3980.00 0.00310 0.000734 0.001660 0.00453
3.7 0.898 5010.00 0.00285 0.000710 0.001460 0.00424
3.8 0.855 6310.00 0.00270 0.000709 0.001310 0.00409
3.9 0.805 7940.00 0.00262 0.000702 0.001240 0.00399
4.0 0.733 10000.00 0.00262 0.000759 0.001130 0.00411
4.1 0.623 12600.00 0.00262 0.000849 0.000956 0.00428
4.2 0.573 15800.00 0.00249 0.000830 0.000862 0.00412
4.3 0.477 20000.00 0.00249 0.000924 0.000679 0.00430
4.4 0.236 25100.00 0.00249 0.001640 -0.000729 0.00571

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 0.002100 0.00513
0.1 1.26 0.995 0.00362 0.000775 0.002100 0.00514
0.2 1.58 0.995 0.00362 0.000775 0.002100 0.00514
0.3 2.00 0.995 0.00362 0.000775 0.002100 0.00514
0.4 2.51 0.995 0.00362 0.000775 0.002100 0.00514
0.5 3.16 0.995 0.00362 0.000775 0.002100 0.00514
0.6 3.98 0.995 0.00362 0.000775 0.002100 0.00514
0.7 5.01 0.994 0.00362 0.000776 0.002100 0.00514
0.8 6.31 0.992 0.00363 0.000776 0.002110 0.00515
0.9 7.94 0.992 0.00348 0.000759 0.001990 0.00497
1.0 10.00 0.992 0.00348 0.000759 0.001990 0.00497
1.1 12.60 0.992 0.00348 0.000759 0.001990 0.00497
1.2 15.80 0.992 0.00348 0.000759 0.001990 0.00497
1.3 20.00 0.992 0.00348 0.000759 0.001990 0.00497
1.4 25.10 0.992 0.00348 0.000759 0.001990 0.00497
1.5 31.60 0.992 0.00348 0.000759 0.001990 0.00497
1.6 39.80 0.992 0.00348 0.000759 0.001990 0.00497
1.7 50.10 0.992 0.00348 0.000759 0.001990 0.00497
1.8 63.10 0.991 0.00348 0.000760 0.002000 0.00497
1.9 79.40 0.991 0.00348 0.000760 0.002000 0.00497
2.0 100.00 0.991 0.00348 0.000760 0.002000 0.00497
2.1 126.00 0.989 0.00349 0.000760 0.002000 0.00498
2.2 158.00 0.988 0.00349 0.000761 0.002000 0.00498
2.3 200.00 0.988 0.00349 0.000761 0.002000 0.00498
2.4 251.00 0.988 0.00349 0.000761 0.002000 0.00498
2.5 316.00 0.986 0.00350 0.000763 0.002010 0.00500
2.6 398.00 0.986 0.00350 0.000763 0.002010 0.00500
2.7 501.00 0.981 0.00351 0.000765 0.002010 0.00501
2.8 631.00 0.981 0.00337 0.000748 0.001900 0.00483
2.9 794.00 0.981 0.00337 0.000748 0.001900 0.00483
3.0 1000.00 0.981 0.00337 0.000748 0.001900 0.00483
3.1 1260.00 0.979 0.00323 0.000731 0.001790 0.00466
3.2 1580.00 0.967 0.00328 0.000743 0.001830 0.00474
3.3 2000.00 0.958 0.00331 0.000749 0.001840 0.00478
3.4 2510.00 0.957 0.00331 0.000751 0.001840 0.00479
3.5 3160.00 0.944 0.00319 0.000739 0.001750 0.00464
3.6 3980.00 0.924 0.00310 0.000734 0.001660 0.00453
3.7 5010.00 0.898 0.00285 0.000710 0.001460 0.00424
3.8 6310.00 0.855 0.00270 0.000709 0.001310 0.00409
3.9 7940.00 0.805 0.00250 0.000702 0.001130 0.00388
4.0 10000.00 0.733 0.00260 0.000759 0.001110 0.00409
4.1 12600.00 0.623 0.00278 0.000849 0.001110 0.00444
4.2 15800.00 0.573 0.00249 0.000830 0.000862 0.00412
4.3 20000.00 0.477 0.00245 0.000924 0.000639 0.00426
4.4 25100.00 0.236 0.00306 0.001640 -0.000157 0.00628

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.217 0.214 -0.20200 0.637
0.1 0.995 1.26 0.217 0.222 -0.21800 0.652
0.2 0.995 1.58 0.217 0.222 -0.21800 0.652
0.3 0.995 2.00 0.217 0.222 -0.21800 0.652
0.4 0.995 2.51 0.217 0.222 -0.21800 0.652
0.5 0.995 3.16 0.217 0.222 -0.21800 0.652
0.6 0.995 3.98 0.217 0.222 -0.21800 0.652
0.7 0.994 5.01 0.217 0.222 -0.21800 0.653
0.8 0.992 6.31 0.217 0.222 -0.21800 0.653
0.9 0.992 7.94 0.246 0.216 -0.17700 0.669
1.0 0.992 10.00 0.246 0.216 -0.17700 0.669
1.1 0.992 12.60 0.246 0.216 -0.17700 0.669
1.2 0.992 15.80 0.246 0.216 -0.17700 0.669
1.3 0.992 20.00 0.246 0.216 -0.17700 0.669
1.4 0.992 25.10 0.246 0.216 -0.17700 0.669
1.5 0.992 31.60 0.246 0.216 -0.17700 0.669
1.6 0.992 39.80 0.246 0.216 -0.17700 0.669
1.7 0.992 50.10 0.246 0.216 -0.17700 0.669
1.8 0.991 63.10 0.246 0.216 -0.17700 0.670
1.9 0.991 79.40 0.246 0.216 -0.17700 0.670
2.0 0.991 100.00 0.246 0.216 -0.17700 0.670
2.1 0.989 126.00 0.246 0.216 -0.17700 0.670
2.2 0.988 158.00 0.246 0.216 -0.17800 0.670
2.3 0.988 200.00 0.246 0.216 -0.17800 0.670
2.4 0.988 251.00 0.246 0.216 -0.17800 0.670
2.5 0.986 316.00 0.246 0.217 -0.17800 0.671
2.6 0.986 398.00 0.246 0.217 -0.17800 0.671
2.7 0.981 501.00 0.246 0.217 -0.17900 0.671
2.8 0.981 631.00 0.272 0.211 -0.14100 0.686
2.9 0.981 794.00 0.272 0.211 -0.14100 0.686
3.0 0.981 1000.00 0.272 0.211 -0.14100 0.686
3.1 0.979 1260.00 0.291 0.206 -0.11300 0.694
3.2 0.967 1580.00 0.291 0.208 -0.11700 0.698
3.3 0.958 2000.00 0.291 0.209 -0.11900 0.700
3.4 0.957 2510.00 0.291 0.209 -0.12000 0.701
3.5 0.944 3160.00 0.310 0.205 -0.09230 0.712
3.6 0.924 3980.00 0.331 0.202 -0.06450 0.726
3.7 0.898 5010.00 0.383 0.192 0.00777 0.759
3.8 0.855 6310.00 0.417 0.188 0.04930 0.786
3.9 0.805 7940.00 0.434 0.185 0.07200 0.796
4.0 0.733 10000.00 0.434 0.195 0.05180 0.816
4.1 0.623 12600.00 0.434 0.212 0.01920 0.849
4.2 0.573 15800.00 0.462 0.206 0.05920 0.865
4.3 0.477 20000.00 0.462 0.223 0.02430 0.900
4.4 0.236 25100.00 0.462 0.369 -0.26100 1.180

IgG V1V2 C.1086-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00361 0.000724 0.002190 0.00503
0.1 0.995 1.26 0.00349 0.000758 0.002000 0.00497
0.2 0.994 1.58 0.00349 0.000758 0.002000 0.00497
0.3 0.994 2.00 0.00349 0.000758 0.002000 0.00497
0.4 0.992 2.51 0.00349 0.000759 0.002000 0.00498
0.5 0.992 3.16 0.00349 0.000759 0.002000 0.00498
0.6 0.992 3.98 0.00349 0.000759 0.002000 0.00498
0.7 0.992 5.01 0.00349 0.000759 0.002000 0.00498
0.8 0.992 6.31 0.00349 0.000759 0.002000 0.00498
0.9 0.992 7.94 0.00349 0.000759 0.002000 0.00498
1.0 0.992 10.00 0.00349 0.000759 0.002000 0.00498
1.1 0.992 12.60 0.00349 0.000759 0.002000 0.00498
1.2 0.992 15.80 0.00349 0.000759 0.002000 0.00498
1.3 0.991 20.00 0.00349 0.000760 0.002000 0.00498
1.4 0.991 25.10 0.00349 0.000760 0.002000 0.00498
1.5 0.989 31.60 0.00349 0.000761 0.002000 0.00498
1.6 0.988 39.80 0.00349 0.000762 0.002000 0.00498
1.7 0.988 50.10 0.00349 0.000762 0.002000 0.00498
1.8 0.988 63.10 0.00349 0.000762 0.002000 0.00498
1.9 0.981 79.40 0.00349 0.000765 0.001990 0.00499
2.0 0.981 100.00 0.00349 0.000765 0.001990 0.00499
2.1 0.981 126.00 0.00349 0.000765 0.001990 0.00499
2.2 0.981 158.00 0.00337 0.000748 0.001900 0.00483
2.3 0.981 200.00 0.00337 0.000748 0.001900 0.00483
2.4 0.981 251.00 0.00337 0.000748 0.001900 0.00483
2.5 0.963 316.00 0.00332 0.000747 0.001860 0.00478
2.6 0.953 398.00 0.00332 0.000753 0.001840 0.00480
2.7 0.949 501.00 0.00332 0.000756 0.001840 0.00480
2.8 0.944 631.00 0.00319 0.000738 0.001740 0.00464
2.9 0.940 794.00 0.00308 0.000720 0.001670 0.00449
3.0 0.931 1000.00 0.00308 0.000725 0.001660 0.00450
3.1 0.902 1260.00 0.00308 0.000744 0.001620 0.00454
3.2 0.849 1580.00 0.00285 0.000730 0.001420 0.00428
3.3 0.795 2000.00 0.00274 0.000744 0.001280 0.00420
3.4 0.741 2510.00 0.00255 0.000745 0.001090 0.00401
3.5 0.637 3160.00 0.00230 0.000762 0.000802 0.00379
3.6 0.558 3980.00 0.00230 0.000807 0.000713 0.00388
3.7 0.471 5010.00 0.00230 0.000876 0.000579 0.00401
3.8 0.393 6310.00 0.00230 0.001100 0.000137 0.00445
3.9 0.285 7940.00 0.00230 0.001340 -0.000325 0.00492
4.0 0.200 10000.00 0.00230 0.001720 -0.001080 0.00567
4.1 0.159 12600.00 0.00230 0.002130 -0.001870 0.00646

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 0.002100 0.00513
0.1 1.26 0.995 0.00348 0.000758 0.001990 0.00496
0.2 1.58 0.994 0.00348 0.000758 0.001990 0.00497
0.3 2.00 0.994 0.00348 0.000758 0.001990 0.00497
0.4 2.51 0.992 0.00348 0.000759 0.001990 0.00497
0.5 3.16 0.992 0.00348 0.000759 0.001990 0.00497
0.6 3.98 0.992 0.00348 0.000759 0.001990 0.00497
0.7 5.01 0.992 0.00348 0.000759 0.001990 0.00497
0.8 6.31 0.992 0.00348 0.000759 0.001990 0.00497
0.9 7.94 0.992 0.00348 0.000759 0.001990 0.00497
1.0 10.00 0.992 0.00348 0.000759 0.001990 0.00497
1.1 12.60 0.992 0.00348 0.000759 0.001990 0.00497
1.2 15.80 0.992 0.00348 0.000759 0.001990 0.00497
1.3 20.00 0.991 0.00348 0.000760 0.002000 0.00497
1.4 25.10 0.991 0.00348 0.000760 0.002000 0.00497
1.5 31.60 0.989 0.00349 0.000761 0.002000 0.00499
1.6 39.80 0.988 0.00350 0.000762 0.002000 0.00499
1.7 50.10 0.988 0.00350 0.000762 0.002000 0.00499
1.8 63.10 0.988 0.00350 0.000762 0.002000 0.00499
1.9 79.40 0.981 0.00351 0.000765 0.002010 0.00501
2.0 100.00 0.981 0.00351 0.000765 0.002010 0.00501
2.1 126.00 0.981 0.00351 0.000765 0.002010 0.00501
2.2 158.00 0.981 0.00337 0.000748 0.001900 0.00483
2.3 200.00 0.981 0.00337 0.000748 0.001900 0.00483
2.4 251.00 0.981 0.00337 0.000748 0.001900 0.00483
2.5 316.00 0.963 0.00330 0.000747 0.001840 0.00477
2.6 398.00 0.953 0.00332 0.000753 0.001850 0.00480
2.7 501.00 0.949 0.00334 0.000756 0.001850 0.00482
2.8 631.00 0.944 0.00319 0.000738 0.001740 0.00464
2.9 794.00 0.940 0.00304 0.000720 0.001630 0.00446
3.0 1000.00 0.931 0.00306 0.000725 0.001640 0.00448
3.1 1260.00 0.902 0.00314 0.000744 0.001680 0.00460
3.2 1580.00 0.849 0.00285 0.000730 0.001420 0.00428
3.3 2000.00 0.795 0.00274 0.000744 0.001280 0.00420
3.4 2510.00 0.741 0.00255 0.000745 0.001090 0.00401
3.5 3160.00 0.637 0.00229 0.000762 0.000800 0.00379
3.6 3980.00 0.558 0.00230 0.000807 0.000715 0.00388
3.7 5010.00 0.471 0.00220 0.000876 0.000479 0.00391
3.8 6310.00 0.393 0.00268 0.001100 0.000520 0.00484
3.9 7940.00 0.285 0.00274 0.001340 0.000122 0.00536
4.0 10000.00 0.200 0.00310 0.001720 -0.000272 0.00648
4.1 12600.00 0.159 0.00377 0.002130 -0.000400 0.00794

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.220 0.214 -0.19900 0.638
0.1 0.995 1.26 0.246 0.216 -0.17700 0.669
0.2 0.994 1.58 0.246 0.216 -0.17700 0.669
0.3 0.994 2.00 0.246 0.216 -0.17700 0.669
0.4 0.992 2.51 0.246 0.216 -0.17700 0.669
0.5 0.992 3.16 0.246 0.216 -0.17700 0.669
0.6 0.992 3.98 0.246 0.216 -0.17700 0.669
0.7 0.992 5.01 0.246 0.216 -0.17700 0.669
0.8 0.992 6.31 0.246 0.216 -0.17700 0.669
0.9 0.992 7.94 0.246 0.216 -0.17700 0.669
1.0 0.992 10.00 0.246 0.216 -0.17700 0.669
1.1 0.992 12.60 0.246 0.216 -0.17700 0.669
1.2 0.992 15.80 0.246 0.216 -0.17700 0.669
1.3 0.991 20.00 0.246 0.216 -0.17700 0.669
1.4 0.991 25.10 0.246 0.216 -0.17700 0.669
1.5 0.989 31.60 0.246 0.216 -0.17800 0.670
1.6 0.988 39.80 0.246 0.216 -0.17800 0.670
1.7 0.988 50.10 0.246 0.216 -0.17800 0.670
1.8 0.988 63.10 0.246 0.216 -0.17800 0.670
1.9 0.981 79.40 0.246 0.217 -0.17900 0.671
2.0 0.981 100.00 0.246 0.217 -0.17900 0.671
2.1 0.981 126.00 0.246 0.217 -0.17900 0.671
2.2 0.981 158.00 0.272 0.211 -0.14100 0.686
2.3 0.981 200.00 0.272 0.211 -0.14100 0.686
2.4 0.981 251.00 0.272 0.211 -0.14100 0.686
2.5 0.963 316.00 0.283 0.210 -0.12800 0.693
2.6 0.953 398.00 0.283 0.210 -0.13000 0.695
2.7 0.949 501.00 0.283 0.211 -0.13100 0.696
2.8 0.944 631.00 0.311 0.205 -0.09040 0.712
2.9 0.940 794.00 0.334 0.199 -0.05600 0.724
3.0 0.931 1000.00 0.334 0.200 -0.05740 0.726
3.1 0.902 1260.00 0.334 0.203 -0.06400 0.732
3.2 0.849 1580.00 0.384 0.195 0.00198 0.766
3.3 0.795 2000.00 0.409 0.195 0.02650 0.791
3.4 0.741 2510.00 0.449 0.191 0.07450 0.823
3.5 0.637 3160.00 0.504 0.189 0.13400 0.874
3.6 0.558 3980.00 0.504 0.197 0.11700 0.891
3.7 0.471 5010.00 0.504 0.211 0.09130 0.917
3.8 0.393 6310.00 0.504 0.255 0.00383 1.000
3.9 0.285 7940.00 0.504 0.303 -0.09040 1.100
4.0 0.200 10000.00 0.504 0.384 -0.24800 1.260
4.1 0.159 12600.00 0.504 0.469 -0.41500 1.420

IgG V1V2 C.1086-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00362 0.000724 0.002200 0.00504
0.1 0.995 1.26 0.00362 0.000775 0.002100 0.00514
0.2 0.995 1.58 0.00362 0.000775 0.002100 0.00514
0.3 0.995 2.00 0.00362 0.000775 0.002100 0.00514
0.4 0.994 2.51 0.00362 0.000776 0.002100 0.00514
0.5 0.992 3.16 0.00362 0.000776 0.002100 0.00514
0.6 0.992 3.98 0.00362 0.000776 0.002100 0.00514
0.7 0.992 5.01 0.00349 0.000759 0.002000 0.00498
0.8 0.992 6.31 0.00349 0.000759 0.002000 0.00498
0.9 0.992 7.94 0.00349 0.000759 0.002000 0.00498
1.0 0.992 10.00 0.00349 0.000759 0.002000 0.00498
1.1 0.991 12.60 0.00349 0.000760 0.002000 0.00498
1.2 0.991 15.80 0.00349 0.000760 0.002000 0.00498
1.3 0.991 20.00 0.00349 0.000760 0.002000 0.00498
1.4 0.991 25.10 0.00349 0.000760 0.002000 0.00498
1.5 0.991 31.60 0.00349 0.000760 0.002000 0.00498
1.6 0.991 39.80 0.00349 0.000760 0.002000 0.00498
1.7 0.991 50.10 0.00349 0.000760 0.002000 0.00498
1.8 0.991 63.10 0.00349 0.000760 0.002000 0.00498
1.9 0.989 79.40 0.00349 0.000761 0.002000 0.00498
2.0 0.988 100.00 0.00349 0.000762 0.002000 0.00499
2.1 0.986 126.00 0.00349 0.000763 0.002000 0.00499
2.2 0.986 158.00 0.00349 0.000763 0.002000 0.00499
2.3 0.986 200.00 0.00349 0.000763 0.002000 0.00499
2.4 0.986 251.00 0.00349 0.000763 0.002000 0.00499
2.5 0.981 316.00 0.00349 0.000765 0.001990 0.00499
2.6 0.981 398.00 0.00349 0.000765 0.001990 0.00499
2.7 0.981 501.00 0.00343 0.000748 0.001960 0.00489
2.8 0.977 631.00 0.00343 0.000753 0.001950 0.00490
2.9 0.960 794.00 0.00343 0.000766 0.001920 0.00493
3.0 0.960 1000.00 0.00343 0.000766 0.001920 0.00493
3.1 0.956 1260.00 0.00343 0.000769 0.001920 0.00493
3.2 0.946 1580.00 0.00334 0.000756 0.001860 0.00482
3.3 0.928 2000.00 0.00308 0.000728 0.001650 0.00450
3.4 0.909 2510.00 0.00306 0.000727 0.001630 0.00449
3.5 0.889 3160.00 0.00306 0.000744 0.001600 0.00452
3.6 0.855 3980.00 0.00306 0.000751 0.001590 0.00453
3.7 0.767 5010.00 0.00306 0.000808 0.001480 0.00464
3.8 0.685 6310.00 0.00306 0.000800 0.001490 0.00463
3.9 0.593 7940.00 0.00306 0.000919 0.001260 0.00486
4.0 0.498 10000.00 0.00306 0.001140 0.000834 0.00529
4.1 0.410 12600.00 0.00306 0.001120 0.000865 0.00526
4.2 0.326 15800.00 0.00306 0.001290 0.000540 0.00558
4.3 0.240 20000.00 0.00306 0.001650 -0.000170 0.00629

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 0.002100 0.00513
0.1 1.26 0.995 0.00362 0.000775 0.002100 0.00514
0.2 1.58 0.995 0.00362 0.000775 0.002100 0.00514
0.3 2.00 0.995 0.00362 0.000775 0.002100 0.00514
0.4 2.51 0.994 0.00362 0.000776 0.002100 0.00514
0.5 3.16 0.992 0.00363 0.000776 0.002110 0.00515
0.6 3.98 0.992 0.00363 0.000776 0.002110 0.00515
0.7 5.01 0.992 0.00348 0.000759 0.001990 0.00497
0.8 6.31 0.992 0.00348 0.000759 0.001990 0.00497
0.9 7.94 0.992 0.00348 0.000759 0.001990 0.00497
1.0 10.00 0.992 0.00348 0.000759 0.001990 0.00497
1.1 12.60 0.991 0.00348 0.000760 0.002000 0.00497
1.2 15.80 0.991 0.00348 0.000760 0.002000 0.00497
1.3 20.00 0.991 0.00348 0.000760 0.002000 0.00497
1.4 25.10 0.991 0.00348 0.000760 0.002000 0.00497
1.5 31.60 0.991 0.00348 0.000760 0.002000 0.00497
1.6 39.80 0.991 0.00348 0.000760 0.002000 0.00497
1.7 50.10 0.991 0.00348 0.000760 0.002000 0.00497
1.8 63.10 0.991 0.00348 0.000760 0.002000 0.00497
1.9 79.40 0.989 0.00349 0.000761 0.002000 0.00499
2.0 100.00 0.988 0.00350 0.000762 0.002010 0.00499
2.1 126.00 0.986 0.00350 0.000763 0.002010 0.00500
2.2 158.00 0.986 0.00350 0.000763 0.002010 0.00500
2.3 200.00 0.986 0.00350 0.000763 0.002010 0.00500
2.4 251.00 0.986 0.00350 0.000763 0.002010 0.00500
2.5 316.00 0.981 0.00351 0.000765 0.002010 0.00501
2.6 398.00 0.981 0.00351 0.000765 0.002010 0.00501
2.7 501.00 0.981 0.00337 0.000748 0.001900 0.00483
2.8 631.00 0.977 0.00339 0.000753 0.001920 0.00487
2.9 794.00 0.960 0.00345 0.000766 0.001950 0.00496
3.0 1000.00 0.960 0.00345 0.000766 0.001950 0.00496
3.1 1260.00 0.956 0.00347 0.000769 0.001960 0.00497
3.2 1580.00 0.946 0.00334 0.000756 0.001860 0.00482
3.3 2000.00 0.928 0.00308 0.000728 0.001650 0.00450
3.4 2510.00 0.909 0.00300 0.000727 0.001570 0.00442
3.5 3160.00 0.889 0.00306 0.000744 0.001600 0.00452
3.6 3980.00 0.855 0.00301 0.000751 0.001540 0.00448
3.7 5010.00 0.767 0.00305 0.000808 0.001460 0.00463
3.8 6310.00 0.685 0.00273 0.000800 0.001160 0.00430
3.9 7940.00 0.593 0.00301 0.000919 0.001210 0.00481
4.0 10000.00 0.498 0.00366 0.001140 0.001430 0.00589
4.1 12600.00 0.410 0.00299 0.001120 0.000793 0.00518
4.2 15800.00 0.326 0.00315 0.001290 0.000632 0.00567
4.3 20000.00 0.240 0.00373 0.001650 0.000501 0.00696

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.217 0.214 -0.2020 0.636
0.1 0.995 1.26 0.217 0.222 -0.2180 0.652
0.2 0.995 1.58 0.217 0.222 -0.2180 0.652
0.3 0.995 2.00 0.217 0.222 -0.2180 0.652
0.4 0.994 2.51 0.217 0.222 -0.2180 0.653
0.5 0.992 3.16 0.217 0.222 -0.2180 0.653
0.6 0.992 3.98 0.217 0.222 -0.2180 0.653
0.7 0.992 5.01 0.246 0.216 -0.1780 0.669
0.8 0.992 6.31 0.246 0.216 -0.1780 0.669
0.9 0.992 7.94 0.246 0.216 -0.1780 0.669
1.0 0.992 10.00 0.246 0.216 -0.1780 0.669
1.1 0.991 12.60 0.246 0.216 -0.1780 0.669
1.2 0.991 15.80 0.246 0.216 -0.1780 0.669
1.3 0.991 20.00 0.246 0.216 -0.1780 0.669
1.4 0.991 25.10 0.246 0.216 -0.1780 0.669
1.5 0.991 31.60 0.246 0.216 -0.1780 0.669
1.6 0.991 39.80 0.246 0.216 -0.1780 0.669
1.7 0.991 50.10 0.246 0.216 -0.1780 0.669
1.8 0.991 63.10 0.246 0.216 -0.1780 0.669
1.9 0.989 79.40 0.246 0.216 -0.1790 0.670
2.0 0.988 100.00 0.246 0.216 -0.1790 0.670
2.1 0.986 126.00 0.246 0.217 -0.1790 0.670
2.2 0.986 158.00 0.246 0.217 -0.1790 0.670
2.3 0.986 200.00 0.246 0.217 -0.1790 0.670
2.4 0.986 251.00 0.246 0.217 -0.1790 0.670
2.5 0.981 316.00 0.246 0.217 -0.1800 0.671
2.6 0.981 398.00 0.246 0.217 -0.1800 0.671
2.7 0.981 501.00 0.259 0.212 -0.1570 0.676
2.8 0.977 631.00 0.259 0.213 -0.1580 0.677
2.9 0.960 794.00 0.259 0.215 -0.1630 0.682
3.0 0.960 1000.00 0.259 0.215 -0.1630 0.682
3.1 0.956 1260.00 0.259 0.216 -0.1640 0.683
3.2 0.946 1580.00 0.278 0.212 -0.1370 0.693
3.3 0.928 2000.00 0.335 0.200 -0.0572 0.728
3.4 0.909 2510.00 0.339 0.200 -0.0527 0.730
3.5 0.889 3160.00 0.339 0.202 -0.0582 0.736
3.6 0.855 3980.00 0.339 0.204 -0.0607 0.738
3.7 0.767 5010.00 0.339 0.214 -0.0802 0.757
3.8 0.685 6310.00 0.339 0.212 -0.0775 0.755
3.9 0.593 7940.00 0.339 0.234 -0.1190 0.797
4.0 0.498 10000.00 0.339 0.275 -0.2000 0.877
4.1 0.410 12600.00 0.339 0.272 -0.1940 0.871
4.2 0.326 15800.00 0.339 0.304 -0.2570 0.934
4.3 0.240 20000.00 0.339 0.377 -0.4000 1.080

IgG3 V1V2 B.CaseA-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00361 0.000724 0.002190 0.00503
0.1 0.976 1.26 0.00341 0.000755 0.001930 0.00489
0.2 0.972 1.58 0.00341 0.000758 0.001930 0.00490
0.3 0.972 2.00 0.00341 0.000758 0.001930 0.00490
0.4 0.948 2.51 0.00339 0.000757 0.001900 0.00487
0.5 0.948 3.16 0.00339 0.000757 0.001900 0.00487
0.6 0.932 3.98 0.00339 0.000769 0.001880 0.00489
0.7 0.921 5.01 0.00339 0.000777 0.001860 0.00491
0.8 0.921 6.31 0.00339 0.000777 0.001860 0.00491
0.9 0.913 7.94 0.00335 0.000764 0.001860 0.00485
1.0 0.882 10.00 0.00335 0.000789 0.001810 0.00490
1.1 0.824 12.60 0.00335 0.000790 0.001810 0.00490
1.2 0.792 15.80 0.00335 0.000821 0.001740 0.00496
1.3 0.754 20.00 0.00335 0.000835 0.001720 0.00499
1.4 0.715 25.10 0.00335 0.000881 0.001630 0.00508
1.5 0.666 31.60 0.00335 0.000904 0.001580 0.00513
1.6 0.614 39.80 0.00324 0.000920 0.001440 0.00504
1.7 0.517 50.10 0.00324 0.001000 0.001280 0.00521
1.8 0.475 63.10 0.00324 0.001040 0.001190 0.00529
1.9 0.400 79.40 0.00316 0.001080 0.001040 0.00529
2.0 0.330 100.00 0.00316 0.001080 0.001040 0.00528
2.1 0.284 126.00 0.00316 0.001240 0.000727 0.00560
2.2 0.232 158.00 0.00316 0.001540 0.000139 0.00619
2.3 0.206 200.00 0.00316 0.001520 0.000189 0.00614
2.4 0.162 251.00 0.00316 0.002080 -0.000907 0.00724
2.5 0.132 316.00 0.00316 0.002880 -0.002490 0.00882

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 0.002100 0.00513
0.1 1.26 0.976 0.00341 0.000755 0.001930 0.00489
0.2 1.58 0.972 0.00342 0.000758 0.001930 0.00490
0.3 2.00 0.972 0.00342 0.000758 0.001930 0.00490
0.4 2.51 0.948 0.00334 0.000757 0.001860 0.00482
0.5 3.16 0.948 0.00334 0.000757 0.001860 0.00482
0.6 3.98 0.932 0.00339 0.000769 0.001890 0.00490
0.7 5.01 0.921 0.00343 0.000777 0.001900 0.00495
0.8 6.31 0.921 0.00343 0.000777 0.001900 0.00495
0.9 7.94 0.913 0.00330 0.000764 0.001800 0.00479
1.0 10.00 0.882 0.00340 0.000789 0.001850 0.00495
1.1 12.60 0.824 0.00324 0.000790 0.001690 0.00479
1.2 15.80 0.792 0.00336 0.000821 0.001750 0.00497
1.3 20.00 0.754 0.00332 0.000835 0.001680 0.00496
1.4 25.10 0.715 0.00349 0.000881 0.001770 0.00522
1.5 31.60 0.666 0.00338 0.000904 0.001610 0.00516
1.6 39.80 0.614 0.00323 0.000920 0.001420 0.00503
1.7 50.10 0.517 0.00326 0.001000 0.001290 0.00522
1.8 63.10 0.475 0.00324 0.001040 0.001190 0.00529
1.9 79.40 0.400 0.00289 0.001080 0.000762 0.00501
2.0 100.00 0.330 0.00229 0.001080 0.000171 0.00441
2.1 126.00 0.284 0.00263 0.001240 0.000191 0.00507
2.2 158.00 0.232 0.00323 0.001540 0.000202 0.00625
2.3 200.00 0.206 0.00285 0.001520 -0.000122 0.00583
2.4 251.00 0.162 0.00379 0.002080 -0.000282 0.00786
2.5 316.00 0.132 0.00448 0.002880 -0.001180 0.01010

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.220 0.214 -0.199 0.638
0.1 0.976 1.26 0.262 0.213 -0.156 0.680
0.2 0.972 1.58 0.262 0.214 -0.157 0.681
0.3 0.972 2.00 0.262 0.214 -0.157 0.681
0.4 0.948 2.51 0.268 0.213 -0.149 0.686
0.5 0.948 3.16 0.268 0.213 -0.149 0.686
0.6 0.932 3.98 0.268 0.215 -0.153 0.690
0.7 0.921 5.01 0.268 0.216 -0.155 0.692
0.8 0.921 6.31 0.268 0.216 -0.155 0.692
0.9 0.913 7.94 0.275 0.213 -0.143 0.693
1.0 0.882 10.00 0.275 0.217 -0.151 0.701
1.1 0.824 12.60 0.275 0.218 -0.151 0.702
1.2 0.792 15.80 0.275 0.223 -0.162 0.712
1.3 0.754 20.00 0.275 0.225 -0.167 0.717
1.4 0.715 25.10 0.275 0.233 -0.182 0.733
1.5 0.666 31.60 0.275 0.238 -0.190 0.741
1.6 0.614 39.80 0.299 0.238 -0.167 0.765
1.7 0.517 50.10 0.299 0.253 -0.196 0.795
1.8 0.475 63.10 0.300 0.261 -0.211 0.811
1.9 0.400 79.40 0.316 0.267 -0.206 0.839
2.0 0.330 100.00 0.316 0.266 -0.206 0.838
2.1 0.284 126.00 0.316 0.297 -0.267 0.899
2.2 0.232 158.00 0.316 0.357 -0.384 1.020
2.3 0.206 200.00 0.316 0.352 -0.374 1.010
2.4 0.162 251.00 0.316 0.467 -0.599 1.230
2.5 0.132 316.00 0.316 0.636 -0.931 1.560

IgG3 V1V2 AE.A244-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00361 0.000724 2.19e-03 0.00503
0.1 0.988 1.26 0.00350 0.000756 2.02e-03 0.00499
0.2 0.988 1.58 0.00350 0.000756 2.02e-03 0.00499
0.3 0.988 2.00 0.00350 0.000756 2.02e-03 0.00499
0.4 0.988 2.51 0.00350 0.000756 2.02e-03 0.00499
0.5 0.988 3.16 0.00350 0.000756 2.02e-03 0.00499
0.6 0.988 3.98 0.00350 0.000756 2.02e-03 0.00499
0.7 0.987 5.01 0.00350 0.000761 2.01e-03 0.00500
0.8 0.985 6.31 0.00350 0.000762 2.01e-03 0.00500
0.9 0.981 7.94 0.00350 0.000765 2.01e-03 0.00500
1.0 0.981 10.00 0.00350 0.000765 2.01e-03 0.00500
1.1 0.980 12.60 0.00350 0.000765 2.00e-03 0.00500
1.2 0.978 15.80 0.00350 0.000766 2.00e-03 0.00501
1.3 0.973 20.00 0.00350 0.000770 1.99e-03 0.00501
1.4 0.971 25.10 0.00341 0.000753 1.93e-03 0.00489
1.5 0.967 31.60 0.00341 0.000756 1.93e-03 0.00489
1.6 0.967 39.80 0.00341 0.000756 1.93e-03 0.00489
1.7 0.960 50.10 0.00341 0.000760 1.92e-03 0.00490
1.8 0.952 63.10 0.00332 0.000747 1.85e-03 0.00478
1.9 0.944 79.40 0.00332 0.000755 1.84e-03 0.00480
2.0 0.934 100.00 0.00322 0.000746 1.76e-03 0.00469
2.1 0.934 126.00 0.00315 0.000724 1.73e-03 0.00457
2.2 0.922 158.00 0.00315 0.000732 1.71e-03 0.00458
2.3 0.895 200.00 0.00315 0.000730 1.72e-03 0.00458
2.4 0.853 251.00 0.00315 0.000763 1.65e-03 0.00464
2.5 0.815 316.00 0.00315 0.000797 1.59e-03 0.00471
2.6 0.751 398.00 0.00315 0.000844 1.50e-03 0.00480
2.7 0.705 501.00 0.00315 0.000841 1.50e-03 0.00480
2.8 0.651 631.00 0.00281 0.000815 1.22e-03 0.00441
2.9 0.583 794.00 0.00281 0.000880 1.09e-03 0.00454
3.0 0.488 1000.00 0.00281 0.001010 8.35e-04 0.00479
3.1 0.404 1260.00 0.00281 0.001130 6.08e-04 0.00502
3.2 0.338 1580.00 0.00281 0.001260 3.52e-04 0.00527
3.3 0.277 2000.00 0.00281 0.001480 -7.81e-05 0.00571
3.4 0.206 2510.00 0.00281 0.002080 -1.26e-03 0.00689
3.5 0.172 3160.00 0.00281 0.002560 -2.21e-03 0.00784
3.6 0.133 3980.00 0.00281 0.002770 -2.62e-03 0.00825
3.7 0.114 5010.00 0.00281 0.002960 -2.99e-03 0.00862

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 2.10e-03 0.00513
0.1 1.26 0.988 0.00349 0.000756 2.01e-03 0.00498
0.2 1.58 0.988 0.00349 0.000756 2.01e-03 0.00498
0.3 2.00 0.988 0.00349 0.000756 2.01e-03 0.00498
0.4 2.51 0.988 0.00349 0.000756 2.01e-03 0.00498
0.5 3.16 0.988 0.00349 0.000756 2.01e-03 0.00498
0.6 3.98 0.988 0.00349 0.000756 2.01e-03 0.00498
0.7 5.01 0.987 0.00349 0.000761 2.00e-03 0.00498
0.8 6.31 0.985 0.00350 0.000762 2.00e-03 0.00499
0.9 7.94 0.981 0.00351 0.000765 2.01e-03 0.00501
1.0 10.00 0.981 0.00351 0.000765 2.01e-03 0.00501
1.1 12.60 0.980 0.00352 0.000765 2.02e-03 0.00502
1.2 15.80 0.978 0.00352 0.000766 2.02e-03 0.00502
1.3 20.00 0.973 0.00354 0.000770 2.03e-03 0.00504
1.4 25.10 0.971 0.00340 0.000753 1.92e-03 0.00487
1.5 31.60 0.967 0.00341 0.000756 1.93e-03 0.00489
1.6 39.80 0.967 0.00341 0.000756 1.93e-03 0.00489
1.7 50.10 0.960 0.00343 0.000760 1.94e-03 0.00492
1.8 63.10 0.952 0.00330 0.000747 1.84e-03 0.00477
1.9 79.40 0.944 0.00333 0.000755 1.85e-03 0.00481
2.0 100.00 0.934 0.00322 0.000746 1.76e-03 0.00469
2.1 126.00 0.934 0.00306 0.000724 1.64e-03 0.00448
2.2 158.00 0.922 0.00309 0.000732 1.66e-03 0.00453
2.3 200.00 0.895 0.00301 0.000730 1.58e-03 0.00444
2.4 251.00 0.853 0.00313 0.000763 1.64e-03 0.00463
2.5 316.00 0.815 0.00326 0.000797 1.70e-03 0.00482
2.6 398.00 0.751 0.00335 0.000844 1.70e-03 0.00501
2.7 501.00 0.705 0.00316 0.000841 1.51e-03 0.00481
2.8 631.00 0.651 0.00268 0.000815 1.08e-03 0.00428
2.9 794.00 0.583 0.00276 0.000880 1.04e-03 0.00449
3.0 1000.00 0.488 0.00301 0.001010 1.03e-03 0.00499
3.1 1260.00 0.404 0.00299 0.001130 7.84e-04 0.00520
3.2 1580.00 0.338 0.00313 0.001260 6.65e-04 0.00559
3.3 2000.00 0.277 0.00339 0.001480 4.97e-04 0.00628
3.4 2510.00 0.206 0.00470 0.002080 6.18e-04 0.00877
3.5 3160.00 0.172 0.00512 0.002560 9.62e-05 0.01010
3.6 3980.00 0.133 0.00495 0.002770 -4.85e-04 0.01040
3.7 5010.00 0.114 0.00463 0.002960 -1.17e-03 0.01040

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.220 0.214 -0.1990 0.638
0.1 0.988 1.26 0.243 0.216 -0.1800 0.666
0.2 0.988 1.58 0.243 0.216 -0.1800 0.666
0.3 0.988 2.00 0.243 0.216 -0.1800 0.666
0.4 0.988 2.51 0.243 0.216 -0.1800 0.666
0.5 0.988 3.16 0.243 0.216 -0.1800 0.666
0.6 0.988 3.98 0.243 0.216 -0.1800 0.666
0.7 0.987 5.01 0.243 0.217 -0.1820 0.667
0.8 0.985 6.31 0.243 0.217 -0.1820 0.668
0.9 0.981 7.94 0.243 0.217 -0.1830 0.669
1.0 0.981 10.00 0.243 0.217 -0.1830 0.669
1.1 0.980 12.60 0.243 0.217 -0.1830 0.669
1.2 0.978 15.80 0.243 0.217 -0.1830 0.669
1.3 0.973 20.00 0.243 0.218 -0.1850 0.670
1.4 0.971 25.10 0.263 0.213 -0.1540 0.680
1.5 0.967 31.60 0.263 0.213 -0.1550 0.681
1.6 0.967 39.80 0.263 0.213 -0.1550 0.681
1.7 0.960 50.10 0.263 0.214 -0.1560 0.682
1.8 0.952 63.10 0.283 0.210 -0.1280 0.694
1.9 0.944 79.40 0.283 0.211 -0.1300 0.696
2.0 0.934 100.00 0.303 0.207 -0.1020 0.709
2.1 0.934 126.00 0.319 0.201 -0.0753 0.714
2.2 0.922 158.00 0.319 0.203 -0.0780 0.717
2.3 0.895 200.00 0.319 0.202 -0.0772 0.716
2.4 0.853 251.00 0.319 0.208 -0.0880 0.727
2.5 0.815 316.00 0.319 0.214 -0.0996 0.738
2.6 0.751 398.00 0.319 0.222 -0.1160 0.755
2.7 0.705 501.00 0.319 0.222 -0.1150 0.754
2.8 0.651 631.00 0.392 0.209 -0.0185 0.802
2.9 0.583 794.00 0.392 0.221 -0.0419 0.826
3.0 0.488 1000.00 0.392 0.246 -0.0898 0.874
3.1 0.404 1260.00 0.392 0.268 -0.1340 0.918
3.2 0.338 1580.00 0.392 0.294 -0.1840 0.968
3.3 0.277 2000.00 0.392 0.338 -0.2710 1.060
3.4 0.206 2510.00 0.392 0.464 -0.5170 1.300
3.5 0.172 3160.00 0.392 0.566 -0.7170 1.500
3.6 0.133 3980.00 0.392 0.610 -0.8040 1.590
3.7 0.114 5010.00 0.392 0.650 -0.8820 1.670

IgG3 V1V2 C.1086-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00365 0.000724 0.002230 0.00507
0.1 0.983 1.26 0.00365 0.000780 0.002120 0.00518
0.2 0.983 1.58 0.00365 0.000780 0.002120 0.00518
0.3 0.983 2.00 0.00365 0.000780 0.002120 0.00518
0.4 0.983 2.51 0.00365 0.000780 0.002120 0.00518
0.5 0.979 3.16 0.00365 0.000784 0.002110 0.00518
0.6 0.979 3.98 0.00352 0.000767 0.002020 0.00502
0.7 0.974 5.01 0.00342 0.000752 0.001940 0.00489
0.8 0.970 6.31 0.00342 0.000754 0.001940 0.00489
0.9 0.963 7.94 0.00342 0.000761 0.001920 0.00491
1.0 0.959 10.00 0.00342 0.000764 0.001920 0.00491
1.1 0.953 12.60 0.00333 0.000749 0.001860 0.00480
1.2 0.942 15.80 0.00333 0.000756 0.001850 0.00481
1.3 0.942 20.00 0.00333 0.000756 0.001850 0.00481
1.4 0.938 25.10 0.00326 0.000741 0.001810 0.00471
1.5 0.929 31.60 0.00326 0.000750 0.001790 0.00473
1.6 0.915 39.80 0.00326 0.000760 0.001770 0.00475
1.7 0.903 50.10 0.00326 0.000769 0.001750 0.00477
1.8 0.870 63.10 0.00319 0.000748 0.001720 0.00465
1.9 0.839 79.40 0.00319 0.000751 0.001710 0.00466
2.0 0.763 100.00 0.00319 0.000831 0.001560 0.00481
2.1 0.706 126.00 0.00319 0.000875 0.001470 0.00490
2.2 0.653 158.00 0.00295 0.000836 0.001320 0.00459
2.3 0.614 200.00 0.00295 0.000900 0.001190 0.00472
2.4 0.551 251.00 0.00295 0.000943 0.001110 0.00480
2.5 0.469 316.00 0.00295 0.000979 0.001030 0.00487
2.6 0.378 398.00 0.00295 0.001280 0.000442 0.00547
2.7 0.329 501.00 0.00295 0.001430 0.000143 0.00576
2.8 0.251 631.00 0.00295 0.001780 -0.000533 0.00644
2.9 0.193 794.00 0.00295 0.002270 -0.001490 0.00740
3.0 0.176 1000.00 0.00295 0.002470 -0.001890 0.00780
3.1 0.134 1260.00 0.00295 0.002450 -0.001840 0.00775

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 0.002100 0.00513
0.1 1.26 0.983 0.00365 0.000780 0.002120 0.00518
0.2 1.58 0.983 0.00365 0.000780 0.002120 0.00518
0.3 2.00 0.983 0.00365 0.000780 0.002120 0.00518
0.4 2.51 0.983 0.00365 0.000780 0.002120 0.00518
0.5 3.16 0.979 0.00367 0.000784 0.002130 0.00520
0.6 3.98 0.979 0.00352 0.000767 0.002020 0.00502
0.7 5.01 0.974 0.00339 0.000752 0.001910 0.00486
0.8 6.31 0.970 0.00340 0.000754 0.001920 0.00488
0.9 7.94 0.963 0.00343 0.000761 0.001940 0.00492
1.0 10.00 0.959 0.00344 0.000764 0.001950 0.00494
1.1 12.60 0.953 0.00331 0.000749 0.001840 0.00478
1.2 15.80 0.942 0.00334 0.000756 0.001860 0.00482
1.3 20.00 0.942 0.00334 0.000756 0.001860 0.00482
1.4 25.10 0.938 0.00320 0.000741 0.001750 0.00466
1.5 31.60 0.929 0.00324 0.000750 0.001770 0.00471
1.6 39.80 0.915 0.00328 0.000760 0.001790 0.00477
1.7 50.10 0.903 0.00332 0.000769 0.001810 0.00483
1.8 63.10 0.870 0.00308 0.000748 0.001610 0.00454
1.9 79.40 0.839 0.00300 0.000751 0.001530 0.00448
2.0 100.00 0.763 0.00331 0.000831 0.001680 0.00494
2.1 126.00 0.706 0.00338 0.000875 0.001660 0.00509
2.2 158.00 0.653 0.00285 0.000836 0.001210 0.00448
2.3 200.00 0.614 0.00306 0.000900 0.001290 0.00482
2.4 251.00 0.551 0.00295 0.000943 0.001110 0.00480
2.5 316.00 0.469 0.00277 0.000979 0.000852 0.00469
2.6 398.00 0.378 0.00354 0.001280 0.001030 0.00606
2.7 501.00 0.329 0.00374 0.001430 0.000930 0.00655
2.8 631.00 0.251 0.00429 0.001780 0.000802 0.00777
2.9 794.00 0.193 0.00507 0.002270 0.000624 0.00952
3.0 1000.00 0.176 0.00497 0.002470 0.000124 0.00981
3.1 1260.00 0.134 0.00389 0.002450 -0.000902 0.00868

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.212 0.215 -0.2080 0.633
0.1 0.983 1.26 0.212 0.224 -0.2260 0.650
0.2 0.983 1.58 0.212 0.224 -0.2260 0.650
0.3 0.983 2.00 0.212 0.224 -0.2260 0.650
0.4 0.983 2.51 0.212 0.224 -0.2260 0.650
0.5 0.979 3.16 0.212 0.224 -0.2270 0.651
0.6 0.979 3.98 0.239 0.218 -0.1880 0.666
0.7 0.974 5.01 0.262 0.213 -0.1550 0.679
0.8 0.970 6.31 0.262 0.213 -0.1560 0.680
0.9 0.963 7.94 0.262 0.214 -0.1580 0.682
1.0 0.959 10.00 0.262 0.215 -0.1590 0.683
1.1 0.953 12.60 0.281 0.210 -0.1310 0.692
1.2 0.942 15.80 0.281 0.211 -0.1340 0.695
1.3 0.942 20.00 0.281 0.211 -0.1340 0.695
1.4 0.938 25.10 0.295 0.207 -0.1100 0.701
1.5 0.929 31.60 0.295 0.209 -0.1130 0.704
1.6 0.915 39.80 0.295 0.210 -0.1160 0.707
1.7 0.903 50.10 0.295 0.212 -0.1200 0.710
1.8 0.870 63.10 0.312 0.206 -0.0927 0.716
1.9 0.839 79.40 0.312 0.207 -0.0938 0.717
2.0 0.763 100.00 0.312 0.221 -0.1210 0.744
2.1 0.706 126.00 0.312 0.228 -0.1360 0.759
2.2 0.653 158.00 0.362 0.216 -0.0621 0.786
2.3 0.614 200.00 0.362 0.228 -0.0851 0.808
2.4 0.551 251.00 0.362 0.236 -0.1010 0.824
2.5 0.469 316.00 0.362 0.243 -0.1140 0.837
2.6 0.378 398.00 0.362 0.301 -0.2290 0.952
2.7 0.329 501.00 0.362 0.332 -0.2890 1.010
2.8 0.251 631.00 0.362 0.402 -0.4270 1.150
2.9 0.193 794.00 0.362 0.504 -0.6270 1.350
3.0 0.176 1000.00 0.362 0.547 -0.7100 1.430
3.1 0.134 1260.00 0.362 0.542 -0.7000 1.420

IgG3 V1V2 C.1086-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00361 0.000724 2.19e-03 0.00503
0.1 0.9840 1.26 0.00355 0.000765 2.05e-03 0.00505
0.2 0.9840 1.58 0.00355 0.000765 2.05e-03 0.00505
0.3 0.9840 2.00 0.00355 0.000765 2.05e-03 0.00505
0.4 0.9790 2.51 0.00355 0.000768 2.04e-03 0.00505
0.5 0.9770 3.16 0.00355 0.000768 2.04e-03 0.00505
0.6 0.9770 3.98 0.00355 0.000768 2.04e-03 0.00505
0.7 0.9720 5.01 0.00355 0.000773 2.03e-03 0.00506
0.8 0.9650 6.31 0.00355 0.000777 2.02e-03 0.00507
0.9 0.9650 7.94 0.00355 0.000777 2.02e-03 0.00507
1.0 0.9590 10.00 0.00355 0.000782 2.02e-03 0.00508
1.1 0.9510 12.60 0.00355 0.000788 2.00e-03 0.00509
1.2 0.9480 15.80 0.00348 0.000772 1.96e-03 0.00499
1.3 0.9470 20.00 0.00336 0.000753 1.88e-03 0.00484
1.4 0.9410 25.10 0.00336 0.000756 1.88e-03 0.00484
1.5 0.9190 31.60 0.00336 0.000775 1.84e-03 0.00488
1.6 0.9070 39.80 0.00335 0.000766 1.85e-03 0.00485
1.7 0.8850 50.10 0.00335 0.000788 1.81e-03 0.00489
1.8 0.8690 63.10 0.00327 0.000759 1.78e-03 0.00475
1.9 0.8690 79.40 0.00327 0.000759 1.78e-03 0.00475
2.0 0.8370 100.00 0.00327 0.000761 1.77e-03 0.00476
2.1 0.7940 126.00 0.00327 0.000786 1.73e-03 0.00481
2.2 0.7390 158.00 0.00327 0.000819 1.66e-03 0.00487
2.3 0.6800 200.00 0.00327 0.000843 1.61e-03 0.00492
2.4 0.6430 251.00 0.00327 0.000887 1.53e-03 0.00501
2.5 0.5840 316.00 0.00327 0.000970 1.37e-03 0.00517
2.6 0.5210 398.00 0.00327 0.001010 1.29e-03 0.00524
2.7 0.4470 501.00 0.00327 0.001180 9.55e-04 0.00558
2.8 0.3610 631.00 0.00327 0.001510 3.12e-04 0.00622
2.9 0.2960 794.00 0.00327 0.001660 2.18e-05 0.00651
3.0 0.2490 1000.00 0.00327 0.001980 -6.09e-04 0.00714
3.1 0.2030 1260.00 0.00327 0.002240 -1.12e-03 0.00765
3.2 0.1500 1580.00 0.00327 0.002330 -1.30e-03 0.00784
3.3 0.1200 2000.00 0.00327 0.002490 -1.62e-03 0.00816
3.4 0.0937 2510.00 0.00327 0.003900 -4.39e-03 0.01090
3.5 0.0656 3160.00 0.00327 0.006600 -9.66e-03 0.01620

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00361 0.000724 0.002100 0.00513
0.1 1.26 0.9840 0.00352 0.000765 0.002020 0.00501
0.2 1.58 0.9840 0.00352 0.000765 0.002020 0.00501
0.3 2.00 0.9840 0.00352 0.000765 0.002020 0.00501
0.4 2.51 0.9790 0.00353 0.000768 0.002020 0.00503
0.5 3.16 0.9770 0.00353 0.000768 0.002020 0.00503
0.6 3.98 0.9770 0.00353 0.000768 0.002020 0.00503
0.7 5.01 0.9720 0.00355 0.000773 0.002030 0.00506
0.8 6.31 0.9650 0.00357 0.000777 0.002040 0.00509
0.9 7.94 0.9650 0.00357 0.000777 0.002040 0.00509
1.0 10.00 0.9590 0.00359 0.000782 0.002060 0.00512
1.1 12.60 0.9510 0.00362 0.000788 0.002070 0.00516
1.2 15.80 0.9480 0.00348 0.000772 0.001960 0.00499
1.3 20.00 0.9470 0.00333 0.000753 0.001850 0.00480
1.4 25.10 0.9410 0.00334 0.000756 0.001860 0.00482
1.5 31.60 0.9190 0.00342 0.000775 0.001900 0.00493
1.6 39.80 0.9070 0.00331 0.000766 0.001800 0.00481
1.7 50.10 0.8850 0.00339 0.000788 0.001850 0.00494
1.8 63.10 0.8690 0.00312 0.000759 0.001630 0.00461
1.9 79.40 0.8690 0.00312 0.000759 0.001630 0.00461
2.0 100.00 0.8370 0.00305 0.000761 0.001560 0.00454
2.1 126.00 0.7940 0.00305 0.000786 0.001510 0.00460
2.2 158.00 0.7390 0.00308 0.000819 0.001480 0.00469
2.3 200.00 0.6800 0.00297 0.000843 0.001310 0.00462
2.4 251.00 0.6430 0.00312 0.000887 0.001380 0.00486
2.5 316.00 0.5840 0.00340 0.000970 0.001500 0.00530
2.6 398.00 0.5210 0.00328 0.001010 0.001300 0.00525
2.7 501.00 0.4470 0.00366 0.001180 0.001340 0.00597
2.8 631.00 0.3610 0.00458 0.001510 0.001630 0.00754
2.9 794.00 0.2960 0.00453 0.001660 0.001280 0.00777
3.0 1000.00 0.2490 0.00464 0.001980 0.000768 0.00852
3.1 1260.00 0.2030 0.00528 0.002240 0.000896 0.00967
3.2 1580.00 0.1500 0.00429 0.002330 -0.000284 0.00886
3.3 2000.00 0.1200 0.00453 0.002490 -0.000354 0.00942
3.4 2510.00 0.0937 0.00681 0.003900 -0.000840 0.01450
3.5 3160.00 0.0656 0.01110 0.006600 -0.001830 0.02400

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.220 0.214 -0.199 0.638
0.1 0.9840 1.26 0.233 0.218 -0.195 0.662
0.2 0.9840 1.58 0.233 0.218 -0.195 0.662
0.3 0.9840 2.00 0.233 0.218 -0.195 0.662
0.4 0.9790 2.51 0.233 0.219 -0.195 0.662
0.5 0.9770 3.16 0.233 0.219 -0.196 0.663
0.6 0.9770 3.98 0.233 0.219 -0.196 0.663
0.7 0.9720 5.01 0.233 0.220 -0.197 0.664
0.8 0.9650 6.31 0.233 0.220 -0.199 0.666
0.9 0.9650 7.94 0.233 0.220 -0.199 0.666
1.0 0.9590 10.00 0.233 0.221 -0.200 0.667
1.1 0.9510 12.60 0.233 0.222 -0.202 0.669
1.2 0.9480 15.80 0.249 0.218 -0.178 0.675
1.3 0.9470 20.00 0.274 0.212 -0.141 0.689
1.4 0.9410 25.10 0.274 0.212 -0.142 0.689
1.5 0.9190 31.60 0.274 0.215 -0.148 0.696
1.6 0.9070 39.80 0.276 0.213 -0.142 0.694
1.7 0.8850 50.10 0.276 0.217 -0.150 0.702
1.8 0.8690 63.10 0.294 0.210 -0.118 0.706
1.9 0.8690 79.40 0.294 0.210 -0.118 0.706
2.0 0.8370 100.00 0.294 0.211 -0.119 0.707
2.1 0.7940 126.00 0.294 0.215 -0.127 0.715
2.2 0.7390 158.00 0.294 0.220 -0.138 0.726
2.3 0.6800 200.00 0.294 0.225 -0.146 0.734
2.4 0.6430 251.00 0.294 0.232 -0.162 0.750
2.5 0.5840 316.00 0.294 0.247 -0.191 0.779
2.6 0.5210 398.00 0.294 0.255 -0.205 0.793
2.7 0.4470 501.00 0.294 0.287 -0.268 0.856
2.8 0.3610 631.00 0.294 0.351 -0.394 0.983
2.9 0.2960 794.00 0.294 0.381 -0.453 1.040
3.0 0.2490 1000.00 0.294 0.447 -0.582 1.170
3.1 0.2030 1260.00 0.294 0.501 -0.688 1.280
3.2 0.1500 1580.00 0.294 0.521 -0.727 1.310
3.3 0.1200 2000.00 0.294 0.555 -0.793 1.380
3.4 0.0937 2510.00 0.294 0.854 -1.380 1.970
3.5 0.0656 3160.00 0.294 1.430 -2.510 3.100

IgG_V1V2_CaseA2_elisa

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
-0.903 1.000 0.125 0.00361 0.000724 2.19e-03 0.00503
-0.803 0.980 0.157 0.00352 0.000766 2.02e-03 0.00502
-0.703 0.914 0.198 0.00346 0.000785 1.92e-03 0.00500
-0.603 0.783 0.249 0.00315 0.000809 1.56e-03 0.00473
-0.503 0.672 0.314 0.00236 0.000746 8.96e-04 0.00382
-0.403 0.486 0.395 0.00234 0.000849 6.72e-04 0.00400
-0.303 0.330 0.498 0.00234 0.001210 -2.56e-05 0.00470

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
-0.903 0.125 1.000 0.00361 0.000724 0.002100 0.00513
-0.803 0.157 0.980 0.00352 0.000766 0.002020 0.00502
-0.703 0.198 0.914 0.00346 0.000785 0.001920 0.00500
-0.603 0.249 0.783 0.00315 0.000809 0.001560 0.00473
-0.503 0.314 0.672 0.00236 0.000746 0.000896 0.00382
-0.403 0.395 0.486 0.00215 0.000849 0.000481 0.00381
-0.303 0.498 0.330 0.00253 0.001210 0.000166 0.00489

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
-0.903 1.000 0.125 0.220 0.214 -0.1990 0.638
-0.803 0.980 0.157 0.239 0.218 -0.1870 0.666
-0.703 0.914 0.198 0.252 0.220 -0.1780 0.682
-0.603 0.783 0.249 0.320 0.216 -0.1030 0.743
-0.503 0.672 0.314 0.491 0.187 0.1240 0.857
-0.403 0.486 0.395 0.495 0.206 0.0908 0.899
-0.303 0.330 0.498 0.495 0.277 -0.0478 1.040

IgG_gp70.V1V2CaseA2

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00361 0.000724 0.002190 0.00503
0.1 0.995 1.26 0.00349 0.000757 0.002010 0.00498
0.2 0.995 1.58 0.00349 0.000757 0.002010 0.00498
0.3 0.995 2.00 0.00349 0.000757 0.002010 0.00498
0.4 0.994 2.51 0.00349 0.000758 0.002010 0.00498
0.5 0.994 3.16 0.00349 0.000758 0.002010 0.00498
0.6 0.985 3.98 0.00349 0.000764 0.002000 0.00499
0.7 0.985 5.01 0.00349 0.000764 0.002000 0.00499
0.8 0.985 6.31 0.00349 0.000764 0.002000 0.00499
0.9 0.985 7.94 0.00349 0.000764 0.002000 0.00499
1.0 0.978 10.00 0.00349 0.000768 0.001990 0.00500
1.1 0.972 12.60 0.00342 0.000754 0.001940 0.00489
1.2 0.963 15.80 0.00342 0.000761 0.001920 0.00491
1.3 0.957 20.00 0.00330 0.000746 0.001830 0.00476
1.4 0.945 25.10 0.00319 0.000738 0.001740 0.00463
1.5 0.930 31.60 0.00310 0.000730 0.001670 0.00453
1.6 0.922 39.80 0.00310 0.000733 0.001670 0.00454
1.7 0.914 50.10 0.00310 0.000742 0.001650 0.00456
1.8 0.895 63.10 0.00291 0.000718 0.001510 0.00432
1.9 0.855 79.40 0.00291 0.000729 0.001490 0.00434
2.0 0.805 100.00 0.00291 0.000776 0.001390 0.00444
2.1 0.741 126.00 0.00263 0.000743 0.001170 0.00409
2.2 0.681 158.00 0.00250 0.000760 0.001010 0.00399
2.3 0.653 200.00 0.00242 0.000771 0.000913 0.00393
2.4 0.591 251.00 0.00212 0.000710 0.000727 0.00351
2.5 0.520 316.00 0.00212 0.000824 0.000503 0.00373
2.6 0.456 398.00 0.00212 0.000842 0.000468 0.00377
2.7 0.375 501.00 0.00212 0.000957 0.000242 0.00399
2.8 0.293 631.00 0.00191 0.001010 -0.000080 0.00390

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 2.10e-03 0.00513
0.1 1.26 0.995 0.00348 0.000757 1.99e-03 0.00496
0.2 1.58 0.995 0.00348 0.000757 1.99e-03 0.00496
0.3 2.00 0.995 0.00348 0.000757 1.99e-03 0.00496
0.4 2.51 0.994 0.00348 0.000758 1.99e-03 0.00497
0.5 3.16 0.994 0.00348 0.000758 1.99e-03 0.00497
0.6 3.98 0.985 0.00351 0.000764 2.01e-03 0.00501
0.7 5.01 0.985 0.00351 0.000764 2.01e-03 0.00501
0.8 6.31 0.985 0.00351 0.000764 2.01e-03 0.00501
0.9 7.94 0.985 0.00351 0.000764 2.01e-03 0.00501
1.0 10.00 0.978 0.00353 0.000768 2.02e-03 0.00503
1.1 12.60 0.972 0.00340 0.000754 1.92e-03 0.00487
1.2 15.80 0.963 0.00343 0.000761 1.94e-03 0.00493
1.3 20.00 0.957 0.00330 0.000746 1.83e-03 0.00476
1.4 25.10 0.945 0.00319 0.000738 1.74e-03 0.00463
1.5 31.60 0.930 0.00308 0.000730 1.65e-03 0.00452
1.6 39.80 0.922 0.00309 0.000733 1.66e-03 0.00453
1.7 50.10 0.914 0.00313 0.000742 1.68e-03 0.00458
1.8 63.10 0.895 0.00288 0.000718 1.48e-03 0.00429
1.9 79.40 0.855 0.00285 0.000729 1.42e-03 0.00428
2.0 100.00 0.805 0.00302 0.000776 1.50e-03 0.00454
2.1 126.00 0.741 0.00263 0.000743 1.17e-03 0.00409
2.2 158.00 0.681 0.00250 0.000760 1.01e-03 0.00399
2.3 200.00 0.653 0.00242 0.000771 9.13e-04 0.00393
2.4 251.00 0.591 0.00192 0.000710 5.27e-04 0.00331
2.5 316.00 0.520 0.00222 0.000824 6.05e-04 0.00384
2.6 398.00 0.456 0.00212 0.000842 4.71e-04 0.00377
2.7 501.00 0.375 0.00221 0.000957 3.38e-04 0.00409
2.8 631.00 0.293 0.00191 0.001010 -7.99e-05 0.00390

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.220 0.214 -0.1990 0.638
0.1 0.995 1.26 0.245 0.216 -0.1780 0.668
0.2 0.995 1.58 0.245 0.216 -0.1780 0.668
0.3 0.995 2.00 0.245 0.216 -0.1780 0.668
0.4 0.994 2.51 0.245 0.216 -0.1780 0.668
0.5 0.994 3.16 0.245 0.216 -0.1780 0.668
0.6 0.985 3.98 0.245 0.217 -0.1800 0.670
0.7 0.985 5.01 0.245 0.217 -0.1800 0.670
0.8 0.985 6.31 0.245 0.217 -0.1800 0.670
0.9 0.985 7.94 0.245 0.217 -0.1800 0.670
1.0 0.978 10.00 0.245 0.218 -0.1820 0.671
1.1 0.972 12.60 0.262 0.213 -0.1560 0.680
1.2 0.963 15.80 0.262 0.214 -0.1580 0.682
1.3 0.957 20.00 0.288 0.209 -0.1210 0.697
1.4 0.945 25.10 0.311 0.205 -0.0900 0.712
1.5 0.930 31.60 0.329 0.201 -0.0649 0.724
1.6 0.922 39.80 0.329 0.202 -0.0658 0.725
1.7 0.914 50.10 0.329 0.203 -0.0687 0.728
1.8 0.895 63.10 0.370 0.195 -0.0110 0.751
1.9 0.855 79.40 0.370 0.196 -0.0147 0.755
2.0 0.805 100.00 0.370 0.205 -0.0309 0.771
2.1 0.741 126.00 0.432 0.192 0.0549 0.808
2.2 0.681 158.00 0.461 0.192 0.0834 0.838
2.3 0.653 200.00 0.476 0.193 0.0979 0.854
2.4 0.591 251.00 0.542 0.175 0.1980 0.886
2.5 0.520 316.00 0.542 0.197 0.1550 0.929
2.6 0.456 398.00 0.542 0.201 0.1480 0.936
2.7 0.375 501.00 0.542 0.224 0.1040 0.981
2.8 0.293 631.00 0.587 0.232 0.1320 1.040

IgG_A244D11K169

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00361 0.000724 0.002190 0.00503
0.1 0.994 1.26 0.00349 0.000758 0.002000 0.00497
0.2 0.994 1.58 0.00349 0.000758 0.002000 0.00497
0.3 0.994 2.00 0.00349 0.000758 0.002000 0.00497
0.4 0.994 2.51 0.00349 0.000758 0.002000 0.00497
0.5 0.994 3.16 0.00349 0.000758 0.002000 0.00497
0.6 0.994 3.98 0.00349 0.000758 0.002000 0.00497
0.7 0.992 5.01 0.00349 0.000759 0.002000 0.00498
0.8 0.992 6.31 0.00349 0.000759 0.002000 0.00498
0.9 0.992 7.94 0.00349 0.000759 0.002000 0.00498
1.0 0.992 10.00 0.00349 0.000759 0.002000 0.00498
1.1 0.992 12.60 0.00349 0.000759 0.002000 0.00498
1.2 0.992 15.80 0.00349 0.000759 0.002000 0.00498
1.3 0.992 20.00 0.00349 0.000759 0.002000 0.00498
1.4 0.991 25.10 0.00349 0.000760 0.002000 0.00498
1.5 0.991 31.60 0.00349 0.000760 0.002000 0.00498
1.6 0.989 39.80 0.00349 0.000760 0.002000 0.00498
1.7 0.989 50.10 0.00349 0.000760 0.002000 0.00498
1.8 0.988 63.10 0.00349 0.000761 0.002000 0.00498
1.9 0.988 79.40 0.00349 0.000761 0.002000 0.00498
2.0 0.986 100.00 0.00349 0.000763 0.001990 0.00498
2.1 0.986 126.00 0.00349 0.000763 0.001990 0.00498
2.2 0.985 158.00 0.00349 0.000764 0.001990 0.00499
2.3 0.985 200.00 0.00349 0.000764 0.001990 0.00499
2.4 0.985 251.00 0.00349 0.000764 0.001990 0.00499
2.5 0.985 316.00 0.00349 0.000764 0.001990 0.00499
2.6 0.985 398.00 0.00349 0.000764 0.001990 0.00499
2.7 0.984 501.00 0.00346 0.000746 0.002000 0.00492
2.8 0.970 631.00 0.00346 0.000757 0.001980 0.00494
2.9 0.959 794.00 0.00346 0.000763 0.001960 0.00495
3.0 0.947 1000.00 0.00346 0.000772 0.001950 0.00497
3.1 0.912 1260.00 0.00346 0.000784 0.001920 0.00500
3.2 0.860 1580.00 0.00346 0.000810 0.001870 0.00505
3.3 0.804 2000.00 0.00346 0.000823 0.001850 0.00507
3.4 0.706 2510.00 0.00346 0.000862 0.001770 0.00515
3.5 0.582 3160.00 0.00346 0.001100 0.001300 0.00562
3.6 0.428 3980.00 0.00346 0.001240 0.001020 0.00590
3.7 0.385 5010.00 0.00346 0.001200 0.001110 0.00581
3.8 0.272 6310.00 0.00346 0.001340 0.000831 0.00609
3.9 0.149 7940.00 0.00346 0.002320 -0.001090 0.00801
4.0 0.085 10000.00 0.00346 0.003790 -0.003980 0.01090

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 0.002100 0.00513
0.1 1.26 0.994 0.00348 0.000758 0.001990 0.00497
0.2 1.58 0.994 0.00348 0.000758 0.001990 0.00497
0.3 2.00 0.994 0.00348 0.000758 0.001990 0.00497
0.4 2.51 0.994 0.00348 0.000758 0.001990 0.00497
0.5 3.16 0.994 0.00348 0.000758 0.001990 0.00497
0.6 3.98 0.994 0.00348 0.000758 0.001990 0.00497
0.7 5.01 0.992 0.00348 0.000759 0.001990 0.00497
0.8 6.31 0.992 0.00348 0.000759 0.001990 0.00497
0.9 7.94 0.992 0.00348 0.000759 0.001990 0.00497
1.0 10.00 0.992 0.00348 0.000759 0.001990 0.00497
1.1 12.60 0.992 0.00348 0.000759 0.001990 0.00497
1.2 15.80 0.992 0.00348 0.000759 0.001990 0.00497
1.3 20.00 0.992 0.00348 0.000759 0.001990 0.00497
1.4 25.10 0.991 0.00348 0.000760 0.002000 0.00497
1.5 31.60 0.991 0.00348 0.000760 0.002000 0.00497
1.6 39.80 0.989 0.00349 0.000760 0.002000 0.00498
1.7 50.10 0.989 0.00349 0.000760 0.002000 0.00498
1.8 63.10 0.988 0.00349 0.000761 0.002000 0.00498
1.9 79.40 0.988 0.00349 0.000761 0.002000 0.00498
2.0 100.00 0.986 0.00350 0.000763 0.002010 0.00500
2.1 126.00 0.986 0.00350 0.000763 0.002010 0.00500
2.2 158.00 0.985 0.00350 0.000764 0.002010 0.00500
2.3 200.00 0.985 0.00350 0.000764 0.002010 0.00500
2.4 251.00 0.985 0.00350 0.000764 0.002010 0.00500
2.5 316.00 0.985 0.00350 0.000764 0.002010 0.00500
2.6 398.00 0.985 0.00350 0.000764 0.002010 0.00500
2.7 501.00 0.984 0.00336 0.000746 0.001900 0.00482
2.8 631.00 0.970 0.00341 0.000757 0.001930 0.00490
2.9 794.00 0.959 0.00344 0.000763 0.001940 0.00494
3.0 1000.00 0.947 0.00348 0.000772 0.001970 0.00499
3.1 1260.00 0.912 0.00346 0.000784 0.001920 0.00499
3.2 1580.00 0.860 0.00348 0.000810 0.001890 0.00507
3.3 2000.00 0.804 0.00337 0.000823 0.001750 0.00498
3.4 2510.00 0.706 0.00322 0.000862 0.001530 0.00491
3.5 3160.00 0.582 0.00370 0.001100 0.001540 0.00587
3.6 3980.00 0.428 0.00379 0.001240 0.001360 0.00623
3.7 5010.00 0.385 0.00330 0.001200 0.000953 0.00566
3.8 6310.00 0.272 0.00328 0.001340 0.000656 0.00591
3.9 7940.00 0.149 0.00511 0.002320 0.000562 0.00966
4.0 10000.00 0.085 0.00562 0.003790 -0.001820 0.01310

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.220 0.214 -0.199 0.638
0.1 0.994 1.26 0.246 0.216 -0.177 0.669
0.2 0.994 1.58 0.246 0.216 -0.177 0.669
0.3 0.994 2.00 0.246 0.216 -0.177 0.669
0.4 0.994 2.51 0.246 0.216 -0.177 0.669
0.5 0.994 3.16 0.246 0.216 -0.177 0.669
0.6 0.994 3.98 0.246 0.216 -0.177 0.669
0.7 0.992 5.01 0.246 0.216 -0.177 0.669
0.8 0.992 6.31 0.246 0.216 -0.177 0.669
0.9 0.992 7.94 0.246 0.216 -0.177 0.669
1.0 0.992 10.00 0.246 0.216 -0.177 0.669
1.1 0.992 12.60 0.246 0.216 -0.177 0.669
1.2 0.992 15.80 0.246 0.216 -0.177 0.669
1.3 0.992 20.00 0.246 0.216 -0.177 0.669
1.4 0.991 25.10 0.246 0.216 -0.177 0.669
1.5 0.991 31.60 0.246 0.216 -0.177 0.669
1.6 0.989 39.80 0.246 0.216 -0.178 0.670
1.7 0.989 50.10 0.246 0.216 -0.178 0.670
1.8 0.988 63.10 0.246 0.216 -0.178 0.670
1.9 0.988 79.40 0.246 0.216 -0.178 0.670
2.0 0.986 100.00 0.246 0.217 -0.178 0.670
2.1 0.986 126.00 0.246 0.217 -0.178 0.670
2.2 0.985 158.00 0.246 0.217 -0.179 0.671
2.3 0.985 200.00 0.246 0.217 -0.179 0.671
2.4 0.985 251.00 0.246 0.217 -0.179 0.671
2.5 0.985 316.00 0.246 0.217 -0.179 0.671
2.6 0.985 398.00 0.246 0.217 -0.179 0.671
2.7 0.984 501.00 0.252 0.213 -0.165 0.670
2.8 0.970 631.00 0.252 0.215 -0.168 0.673
2.9 0.959 794.00 0.252 0.216 -0.171 0.675
3.0 0.947 1000.00 0.252 0.217 -0.173 0.678
3.1 0.912 1260.00 0.252 0.219 -0.177 0.682
3.2 0.860 1580.00 0.252 0.224 -0.186 0.691
3.3 0.804 2000.00 0.252 0.226 -0.190 0.695
3.4 0.706 2510.00 0.252 0.233 -0.203 0.708
3.5 0.582 3160.00 0.252 0.276 -0.288 0.793
3.6 0.428 3980.00 0.252 0.303 -0.340 0.845
3.7 0.385 5010.00 0.252 0.294 -0.324 0.829
3.8 0.272 6310.00 0.252 0.321 -0.378 0.883
3.9 0.149 7940.00 0.252 0.520 -0.767 1.270
4.0 0.085 10000.00 0.252 0.832 -1.380 1.880

IgG_gp70ClAEV1V2

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00362 0.000724 0.00220 0.00504
0.1 0.997 1.26 0.00362 0.000774 0.00211 0.00514
0.2 0.997 1.58 0.00362 0.000774 0.00211 0.00514
0.3 0.997 2.00 0.00362 0.000774 0.00211 0.00514
0.4 0.995 2.51 0.00362 0.000775 0.00210 0.00514
0.5 0.994 3.16 0.00362 0.000776 0.00210 0.00514
0.6 0.992 3.98 0.00362 0.000776 0.00210 0.00514
0.7 0.992 5.01 0.00362 0.000776 0.00210 0.00514
0.8 0.992 6.31 0.00362 0.000776 0.00210 0.00514
0.9 0.992 7.94 0.00362 0.000776 0.00210 0.00514
1.0 0.992 10.00 0.00362 0.000776 0.00210 0.00514
1.1 0.992 12.60 0.00362 0.000776 0.00210 0.00514
1.2 0.992 15.80 0.00362 0.000776 0.00210 0.00514
1.3 0.992 20.00 0.00349 0.000759 0.00200 0.00498
1.4 0.992 25.10 0.00349 0.000759 0.00200 0.00498
1.5 0.992 31.60 0.00349 0.000759 0.00200 0.00498
1.6 0.992 39.80 0.00349 0.000759 0.00200 0.00498
1.7 0.991 50.10 0.00349 0.000760 0.00200 0.00498
1.8 0.991 63.10 0.00349 0.000760 0.00200 0.00498
1.9 0.991 79.40 0.00349 0.000760 0.00200 0.00498
2.0 0.991 100.00 0.00349 0.000760 0.00200 0.00498
2.1 0.991 126.00 0.00349 0.000760 0.00200 0.00498
2.2 0.991 158.00 0.00349 0.000760 0.00200 0.00498
2.3 0.991 200.00 0.00349 0.000760 0.00200 0.00498
2.4 0.989 251.00 0.00349 0.000761 0.00200 0.00498
2.5 0.988 316.00 0.00349 0.000762 0.00200 0.00498
2.6 0.986 398.00 0.00349 0.000763 0.00200 0.00499
2.7 0.986 501.00 0.00349 0.000763 0.00200 0.00499
2.8 0.986 631.00 0.00349 0.000763 0.00200 0.00499
2.9 0.981 794.00 0.00349 0.000765 0.00199 0.00499
3.0 0.981 1000.00 0.00349 0.000765 0.00199 0.00499
3.1 0.981 1260.00 0.00342 0.000748 0.00196 0.00489
3.2 0.977 1580.00 0.00342 0.000753 0.00195 0.00490
3.3 0.972 2000.00 0.00342 0.000755 0.00194 0.00490
3.4 0.960 2510.00 0.00342 0.000766 0.00192 0.00493
3.5 0.960 3160.00 0.00342 0.000766 0.00192 0.00493
3.6 0.956 3980.00 0.00342 0.000769 0.00192 0.00493
3.7 0.956 5010.00 0.00318 0.000732 0.00174 0.00461
3.8 0.945 6310.00 0.00318 0.000738 0.00173 0.00463
3.9 0.923 7940.00 0.00300 0.000718 0.00159 0.00441
4.0 0.914 10000.00 0.00300 0.000724 0.00158 0.00442
4.1 0.868 12600.00 0.00300 0.000748 0.00154 0.00447
4.2 0.807 15800.00 0.00300 0.000788 0.00146 0.00455
4.3 0.729 20000.00 0.00294 0.000805 0.00136 0.00452
4.4 0.401 25100.00 0.00294 0.001230 0.00054 0.00534

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 0.00210 0.00513
0.1 1.26 0.997 0.00362 0.000774 0.00210 0.00514
0.2 1.58 0.997 0.00362 0.000774 0.00210 0.00514
0.3 2.00 0.997 0.00362 0.000774 0.00210 0.00514
0.4 2.51 0.995 0.00362 0.000775 0.00210 0.00514
0.5 3.16 0.994 0.00362 0.000776 0.00210 0.00514
0.6 3.98 0.992 0.00363 0.000776 0.00211 0.00515
0.7 5.01 0.992 0.00363 0.000776 0.00211 0.00515
0.8 6.31 0.992 0.00363 0.000776 0.00211 0.00515
0.9 7.94 0.992 0.00363 0.000776 0.00211 0.00515
1.0 10.00 0.992 0.00363 0.000776 0.00211 0.00515
1.1 12.60 0.992 0.00363 0.000776 0.00211 0.00515
1.2 15.80 0.992 0.00363 0.000776 0.00211 0.00515
1.3 20.00 0.992 0.00348 0.000759 0.00199 0.00497
1.4 25.10 0.992 0.00348 0.000759 0.00199 0.00497
1.5 31.60 0.992 0.00348 0.000759 0.00199 0.00497
1.6 39.80 0.992 0.00348 0.000759 0.00199 0.00497
1.7 50.10 0.991 0.00348 0.000760 0.00200 0.00497
1.8 63.10 0.991 0.00348 0.000760 0.00200 0.00497
1.9 79.40 0.991 0.00348 0.000760 0.00200 0.00497
2.0 100.00 0.991 0.00348 0.000760 0.00200 0.00497
2.1 126.00 0.991 0.00348 0.000760 0.00200 0.00497
2.2 158.00 0.991 0.00348 0.000760 0.00200 0.00497
2.3 200.00 0.991 0.00348 0.000760 0.00200 0.00497
2.4 251.00 0.989 0.00349 0.000761 0.00200 0.00499
2.5 316.00 0.988 0.00350 0.000762 0.00200 0.00499
2.6 398.00 0.986 0.00350 0.000763 0.00201 0.00500
2.7 501.00 0.986 0.00350 0.000763 0.00201 0.00500
2.8 631.00 0.986 0.00350 0.000763 0.00201 0.00500
2.9 794.00 0.981 0.00351 0.000765 0.00201 0.00501
3.0 1000.00 0.981 0.00351 0.000765 0.00201 0.00501
3.1 1260.00 0.981 0.00337 0.000748 0.00190 0.00483
3.2 1580.00 0.977 0.00339 0.000753 0.00192 0.00487
3.3 2000.00 0.972 0.00341 0.000755 0.00193 0.00489
3.4 2510.00 0.960 0.00345 0.000766 0.00195 0.00496
3.5 3160.00 0.960 0.00345 0.000766 0.00195 0.00496
3.6 3980.00 0.956 0.00347 0.000769 0.00196 0.00497
3.7 5010.00 0.956 0.00317 0.000732 0.00173 0.00460
3.8 6310.00 0.945 0.00319 0.000738 0.00175 0.00464
3.9 7940.00 0.923 0.00296 0.000718 0.00156 0.00437
4.0 10000.00 0.914 0.00298 0.000724 0.00157 0.00440
4.1 12600.00 0.868 0.00300 0.000748 0.00153 0.00446
4.2 15800.00 0.807 0.00306 0.000788 0.00152 0.00461
4.3 20000.00 0.729 0.00294 0.000805 0.00136 0.00452
4.4 25100.00 0.401 0.00345 0.001230 0.00105 0.00585

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.217 0.214 -0.2020 0.636
0.1 0.997 1.26 0.217 0.222 -0.2180 0.652
0.2 0.997 1.58 0.217 0.222 -0.2180 0.652
0.3 0.997 2.00 0.217 0.222 -0.2180 0.652
0.4 0.995 2.51 0.217 0.222 -0.2180 0.652
0.5 0.994 3.16 0.217 0.222 -0.2180 0.652
0.6 0.992 3.98 0.217 0.222 -0.2190 0.653
0.7 0.992 5.01 0.217 0.222 -0.2190 0.653
0.8 0.992 6.31 0.217 0.222 -0.2190 0.653
0.9 0.992 7.94 0.217 0.222 -0.2190 0.653
1.0 0.992 10.00 0.217 0.222 -0.2190 0.653
1.1 0.992 12.60 0.217 0.222 -0.2190 0.653
1.2 0.992 15.80 0.217 0.222 -0.2190 0.653
1.3 0.992 20.00 0.246 0.216 -0.1780 0.669
1.4 0.992 25.10 0.246 0.216 -0.1780 0.669
1.5 0.992 31.60 0.246 0.216 -0.1780 0.669
1.6 0.992 39.80 0.246 0.216 -0.1780 0.669
1.7 0.991 50.10 0.246 0.216 -0.1780 0.669
1.8 0.991 63.10 0.246 0.216 -0.1780 0.669
1.9 0.991 79.40 0.246 0.216 -0.1780 0.669
2.0 0.991 100.00 0.246 0.216 -0.1780 0.669
2.1 0.991 126.00 0.246 0.216 -0.1780 0.669
2.2 0.991 158.00 0.246 0.216 -0.1780 0.669
2.3 0.991 200.00 0.246 0.216 -0.1780 0.669
2.4 0.989 251.00 0.246 0.216 -0.1780 0.670
2.5 0.988 316.00 0.246 0.216 -0.1790 0.670
2.6 0.986 398.00 0.246 0.217 -0.1790 0.670
2.7 0.986 501.00 0.246 0.217 -0.1790 0.670
2.8 0.986 631.00 0.246 0.217 -0.1790 0.670
2.9 0.981 794.00 0.246 0.217 -0.1800 0.671
3.0 0.981 1000.00 0.246 0.217 -0.1800 0.671
3.1 0.981 1260.00 0.260 0.212 -0.1560 0.676
3.2 0.977 1580.00 0.260 0.213 -0.1580 0.678
3.3 0.972 2000.00 0.260 0.214 -0.1590 0.679
3.4 0.960 2510.00 0.260 0.215 -0.1620 0.682
3.5 0.960 3160.00 0.260 0.215 -0.1620 0.682
3.6 0.956 3980.00 0.260 0.216 -0.1630 0.683
3.7 0.956 5010.00 0.313 0.203 -0.0857 0.712
3.8 0.945 6310.00 0.313 0.205 -0.0879 0.714
3.9 0.923 7940.00 0.351 0.197 -0.0340 0.737
4.0 0.914 10000.00 0.351 0.198 -0.0360 0.739
4.1 0.868 12600.00 0.351 0.202 -0.0440 0.747
4.2 0.807 15800.00 0.351 0.209 -0.0579 0.761
4.3 0.729 20000.00 0.364 0.210 -0.0482 0.777
4.4 0.401 25100.00 0.364 0.290 -0.2050 0.933

IgG_gp70V1V2A

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00361 0.000724 2.19e-03 0.00503
0.1 0.9920 1.26 0.00352 0.000759 2.03e-03 0.00501
0.2 0.9920 1.58 0.00352 0.000759 2.03e-03 0.00501
0.3 0.9920 2.00 0.00352 0.000759 2.03e-03 0.00501
0.4 0.9910 2.51 0.00352 0.000761 2.03e-03 0.00501
0.5 0.9890 3.16 0.00352 0.000761 2.03e-03 0.00501
0.6 0.9890 3.98 0.00352 0.000761 2.03e-03 0.00501
0.7 0.9880 5.01 0.00352 0.000762 2.02e-03 0.00501
0.8 0.9860 6.31 0.00352 0.000763 2.02e-03 0.00501
0.9 0.9820 7.94 0.00352 0.000765 2.02e-03 0.00502
1.0 0.9820 10.00 0.00352 0.000765 2.02e-03 0.00502
1.1 0.9820 12.60 0.00352 0.000765 2.02e-03 0.00502
1.2 0.9680 15.80 0.00352 0.000775 2.00e-03 0.00504
1.3 0.9680 20.00 0.00352 0.000775 2.00e-03 0.00504
1.4 0.9680 25.10 0.00352 0.000775 2.00e-03 0.00504
1.5 0.9680 31.60 0.00352 0.000775 2.00e-03 0.00504
1.6 0.9530 39.80 0.00347 0.000767 1.97e-03 0.00498
1.7 0.9480 50.10 0.00347 0.000774 1.96e-03 0.00499
1.8 0.9420 63.10 0.00338 0.000760 1.89e-03 0.00487
1.9 0.9290 79.40 0.00338 0.000772 1.87e-03 0.00489
2.0 0.9000 100.00 0.00332 0.000769 1.81e-03 0.00482
2.1 0.8790 126.00 0.00323 0.000768 1.73e-03 0.00474
2.2 0.8520 158.00 0.00286 0.000732 1.42e-03 0.00429
2.3 0.8390 200.00 0.00254 0.000689 1.19e-03 0.00389
2.4 0.8080 251.00 0.00246 0.000691 1.11e-03 0.00382
2.5 0.7580 316.00 0.00206 0.000648 7.92e-04 0.00333
2.6 0.7120 398.00 0.00206 0.000629 8.28e-04 0.00329
2.7 0.6310 501.00 0.00206 0.000675 7.37e-04 0.00338
2.8 0.5160 631.00 0.00206 0.000755 5.80e-04 0.00354
2.9 0.4650 794.00 0.00206 0.000850 3.95e-04 0.00373
3.0 0.4290 1000.00 0.00206 0.000831 4.31e-04 0.00369
3.1 0.3440 1260.00 0.00206 0.000961 1.76e-04 0.00395
3.2 0.2870 1580.00 0.00206 0.001100 -8.71e-05 0.00421
3.3 0.2160 2000.00 0.00206 0.001380 -6.51e-04 0.00477
3.4 0.1630 2510.00 0.00206 0.001870 -1.60e-03 0.00572
3.5 0.1300 3160.00 0.00206 0.002510 -2.86e-03 0.00698
3.6 0.0981 3980.00 0.00206 0.003960 -5.70e-03 0.00982

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00361 0.000724 0.002100 0.00513
0.1 1.26 0.9920 0.00348 0.000759 0.002000 0.00497
0.2 1.58 0.9920 0.00348 0.000759 0.002000 0.00497
0.3 2.00 0.9920 0.00348 0.000759 0.002000 0.00497
0.4 2.51 0.9910 0.00349 0.000761 0.002000 0.00498
0.5 3.16 0.9890 0.00350 0.000761 0.002000 0.00499
0.6 3.98 0.9890 0.00350 0.000761 0.002000 0.00499
0.7 5.01 0.9880 0.00350 0.000762 0.002010 0.00499
0.8 6.31 0.9860 0.00350 0.000763 0.002010 0.00500
0.9 7.94 0.9820 0.00352 0.000765 0.002020 0.00502
1.0 10.00 0.9820 0.00352 0.000765 0.002020 0.00502
1.1 12.60 0.9820 0.00352 0.000765 0.002020 0.00502
1.2 15.80 0.9680 0.00357 0.000775 0.002050 0.00509
1.3 20.00 0.9680 0.00357 0.000775 0.002050 0.00509
1.4 25.10 0.9680 0.00357 0.000775 0.002050 0.00509
1.5 31.60 0.9680 0.00357 0.000775 0.002050 0.00509
1.6 39.80 0.9530 0.00346 0.000767 0.001960 0.00496
1.7 50.10 0.9480 0.00349 0.000774 0.001970 0.00500
1.8 63.10 0.9420 0.00336 0.000760 0.001870 0.00484
1.9 79.40 0.9290 0.00341 0.000772 0.001890 0.00492
2.0 100.00 0.9000 0.00332 0.000769 0.001810 0.00482
2.1 126.00 0.8790 0.00323 0.000768 0.001730 0.00474
2.2 158.00 0.8520 0.00286 0.000732 0.001420 0.00429
2.3 200.00 0.8390 0.00254 0.000689 0.001190 0.00389
2.4 251.00 0.8080 0.00246 0.000691 0.001110 0.00382
2.5 316.00 0.7580 0.00205 0.000648 0.000785 0.00332
2.6 398.00 0.7120 0.00181 0.000629 0.000579 0.00305
2.7 501.00 0.6310 0.00182 0.000675 0.000502 0.00315
2.8 631.00 0.5160 0.00189 0.000755 0.000405 0.00337
2.9 794.00 0.4650 0.00212 0.000850 0.000454 0.00378
3.0 1000.00 0.4290 0.00190 0.000831 0.000275 0.00353
3.1 1260.00 0.3440 0.00175 0.000961 -0.000134 0.00363
3.2 1580.00 0.2870 0.00201 0.001100 -0.000142 0.00415
3.3 2000.00 0.2160 0.00259 0.001380 -0.000121 0.00530
3.4 2510.00 0.1630 0.00349 0.001870 -0.000174 0.00715
3.5 3160.00 0.1300 0.00463 0.002510 -0.000286 0.00955
3.6 3980.00 0.0981 0.00694 0.003960 -0.000818 0.01470

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.220 0.214 -0.199000 0.638
0.1 0.9920 1.26 0.240 0.217 -0.185000 0.664
0.2 0.9920 1.58 0.240 0.217 -0.185000 0.664
0.3 0.9920 2.00 0.240 0.217 -0.185000 0.664
0.4 0.9910 2.51 0.240 0.217 -0.185000 0.665
0.5 0.9890 3.16 0.240 0.217 -0.186000 0.665
0.6 0.9890 3.98 0.240 0.217 -0.186000 0.665
0.7 0.9880 5.01 0.240 0.217 -0.186000 0.666
0.8 0.9860 6.31 0.240 0.217 -0.186000 0.666
0.9 0.9820 7.94 0.240 0.218 -0.187000 0.666
1.0 0.9820 10.00 0.240 0.218 -0.187000 0.666
1.1 0.9820 12.60 0.240 0.218 -0.187000 0.666
1.2 0.9680 15.80 0.240 0.219 -0.190000 0.670
1.3 0.9680 20.00 0.240 0.219 -0.190000 0.670
1.4 0.9680 25.10 0.240 0.219 -0.190000 0.670
1.5 0.9680 31.60 0.240 0.219 -0.190000 0.670
1.6 0.9530 39.80 0.250 0.217 -0.175000 0.675
1.7 0.9480 50.10 0.250 0.218 -0.178000 0.677
1.8 0.9420 63.10 0.269 0.213 -0.149000 0.687
1.9 0.9290 79.40 0.269 0.215 -0.153000 0.691
2.0 0.9000 100.00 0.283 0.213 -0.135000 0.701
2.1 0.8790 126.00 0.301 0.211 -0.112000 0.714
2.2 0.8520 158.00 0.383 0.195 -0.000602 0.766
2.3 0.8390 200.00 0.451 0.181 0.097600 0.805
2.4 0.8080 251.00 0.468 0.179 0.117000 0.819
2.5 0.7580 316.00 0.555 0.163 0.236000 0.873
2.6 0.7120 398.00 0.555 0.159 0.243000 0.867
2.7 0.6310 501.00 0.555 0.168 0.226000 0.884
2.8 0.5160 631.00 0.555 0.183 0.196000 0.914
2.9 0.4650 794.00 0.555 0.202 0.160000 0.950
3.0 0.4290 1000.00 0.555 0.198 0.167000 0.943
3.1 0.3440 1260.00 0.555 0.224 0.116000 0.993
3.2 0.2870 1580.00 0.555 0.251 0.062900 1.050
3.3 0.2160 2000.00 0.555 0.310 -0.053400 1.160
3.4 0.1630 2510.00 0.555 0.412 -0.253000 1.360
3.5 0.1300 3160.00 0.555 0.549 -0.521000 1.630
3.6 0.0981 3980.00 0.555 0.859 -1.130000 2.240

IgG_gp70V1V2AP

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00361 0.000724 0.002190 0.00503
0.1 0.998 1.26 0.00348 0.000756 0.002000 0.00497
0.2 0.998 1.58 0.00348 0.000756 0.002000 0.00497
0.3 0.998 2.00 0.00348 0.000756 0.002000 0.00497
0.4 0.997 2.51 0.00348 0.000757 0.002000 0.00497
0.5 0.997 3.16 0.00348 0.000757 0.002000 0.00497
0.6 0.992 3.98 0.00348 0.000759 0.002000 0.00497
0.7 0.987 5.01 0.00348 0.000762 0.001990 0.00498
0.8 0.982 6.31 0.00348 0.000765 0.001980 0.00498
0.9 0.974 7.94 0.00342 0.000753 0.001940 0.00490
1.0 0.974 10.00 0.00342 0.000753 0.001940 0.00490
1.1 0.974 12.60 0.00342 0.000753 0.001940 0.00490
1.2 0.974 15.80 0.00342 0.000753 0.001940 0.00490
1.3 0.958 20.00 0.00342 0.000767 0.001920 0.00492
1.4 0.950 25.10 0.00342 0.000773 0.001900 0.00493
1.5 0.950 31.60 0.00334 0.000754 0.001860 0.00482
1.6 0.940 39.80 0.00334 0.000759 0.001850 0.00483
1.7 0.919 50.10 0.00312 0.000734 0.001680 0.00456
1.8 0.908 63.10 0.00312 0.000743 0.001660 0.00457
1.9 0.885 79.40 0.00294 0.000720 0.001530 0.00435
2.0 0.844 100.00 0.00294 0.000748 0.001480 0.00441
2.1 0.792 126.00 0.00271 0.000739 0.001270 0.00416
2.2 0.735 158.00 0.00258 0.000726 0.001150 0.00400
2.3 0.652 200.00 0.00258 0.000789 0.001030 0.00412
2.4 0.606 251.00 0.00258 0.000811 0.000986 0.00417
2.5 0.524 316.00 0.00258 0.000902 0.000808 0.00435
2.6 0.460 398.00 0.00258 0.001030 0.000558 0.00459
2.7 0.398 501.00 0.00258 0.001190 0.000241 0.00491
2.8 0.341 631.00 0.00258 0.001130 0.000366 0.00479
2.9 0.258 794.00 0.00258 0.001230 0.000166 0.00499
3.0 0.207 1000.00 0.00258 0.001660 -0.000673 0.00583
3.1 0.175 1260.00 0.00258 0.001250 0.000119 0.00503
3.2 0.124 1580.00 0.00258 0.002010 -0.001360 0.00651

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 0.002100 0.00513
0.1 1.26 0.998 0.00347 0.000756 0.001990 0.00495
0.2 1.58 0.998 0.00347 0.000756 0.001990 0.00495
0.3 2.00 0.998 0.00347 0.000756 0.001990 0.00495
0.4 2.51 0.997 0.00347 0.000757 0.001990 0.00496
0.5 3.16 0.997 0.00347 0.000757 0.001990 0.00496
0.6 3.98 0.992 0.00348 0.000759 0.001990 0.00497
0.7 5.01 0.987 0.00350 0.000762 0.002010 0.00500
0.8 6.31 0.982 0.00352 0.000765 0.002020 0.00501
0.9 7.94 0.974 0.00339 0.000753 0.001920 0.00487
1.0 10.00 0.974 0.00339 0.000753 0.001920 0.00487
1.1 12.60 0.974 0.00339 0.000753 0.001920 0.00487
1.2 15.80 0.974 0.00339 0.000753 0.001920 0.00487
1.3 20.00 0.958 0.00346 0.000767 0.001960 0.00496
1.4 25.10 0.950 0.00348 0.000773 0.001970 0.00500
1.5 31.60 0.950 0.00333 0.000754 0.001850 0.00481
1.6 39.80 0.940 0.00335 0.000759 0.001860 0.00484
1.7 50.10 0.919 0.00310 0.000734 0.001660 0.00454
1.8 63.10 0.908 0.00313 0.000743 0.001680 0.00459
1.9 79.40 0.885 0.00289 0.000720 0.001480 0.00430
2.0 100.00 0.844 0.00300 0.000748 0.001530 0.00446
2.1 126.00 0.792 0.00271 0.000739 0.001270 0.00416
2.2 158.00 0.735 0.00249 0.000726 0.001060 0.00391
2.3 200.00 0.652 0.00259 0.000789 0.001050 0.00414
2.4 251.00 0.606 0.00255 0.000811 0.000963 0.00414
2.5 316.00 0.524 0.00269 0.000902 0.000921 0.00446
2.6 398.00 0.460 0.00290 0.001030 0.000886 0.00492
2.7 501.00 0.398 0.00333 0.001190 0.000996 0.00567
2.8 631.00 0.341 0.00278 0.001130 0.000568 0.00499
2.9 794.00 0.258 0.00227 0.001230 -0.000137 0.00468
3.0 1000.00 0.207 0.00296 0.001660 -0.000289 0.00621
3.1 1260.00 0.175 0.00207 0.001250 -0.000392 0.00452
3.2 1580.00 0.124 0.00325 0.002010 -0.000692 0.00718

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.220 0.214 -0.1990 0.638
0.1 0.998 1.26 0.247 0.215 -0.1750 0.669
0.2 0.998 1.58 0.247 0.215 -0.1750 0.669
0.3 0.998 2.00 0.247 0.215 -0.1750 0.669
0.4 0.997 2.51 0.247 0.215 -0.1750 0.670
0.5 0.997 3.16 0.247 0.215 -0.1750 0.670
0.6 0.992 3.98 0.247 0.216 -0.1750 0.670
0.7 0.987 5.01 0.247 0.216 -0.1770 0.671
0.8 0.982 6.31 0.247 0.217 -0.1770 0.672
0.9 0.974 7.94 0.261 0.213 -0.1570 0.679
1.0 0.974 10.00 0.261 0.213 -0.1570 0.679
1.1 0.974 12.60 0.261 0.213 -0.1570 0.679
1.2 0.974 15.80 0.261 0.213 -0.1570 0.679
1.3 0.958 20.00 0.261 0.215 -0.1610 0.683
1.4 0.950 25.10 0.261 0.216 -0.1630 0.685
1.5 0.950 31.60 0.278 0.211 -0.1360 0.692
1.6 0.940 39.80 0.278 0.212 -0.1380 0.694
1.7 0.919 50.10 0.326 0.202 -0.0700 0.723
1.8 0.908 63.10 0.326 0.204 -0.0729 0.726
1.9 0.885 79.40 0.364 0.196 -0.0191 0.747
2.0 0.844 100.00 0.364 0.200 -0.0286 0.757
2.1 0.792 126.00 0.414 0.193 0.0345 0.793
2.2 0.735 158.00 0.443 0.188 0.0747 0.812
2.3 0.652 200.00 0.443 0.200 0.0521 0.834
2.4 0.606 251.00 0.443 0.204 0.0440 0.842
2.5 0.524 316.00 0.443 0.221 0.0104 0.876
2.6 0.460 398.00 0.443 0.245 -0.0379 0.924
2.7 0.398 501.00 0.443 0.278 -0.1010 0.987
2.8 0.341 631.00 0.443 0.265 -0.0759 0.962
2.9 0.258 794.00 0.443 0.285 -0.1160 1.000
3.0 0.207 1000.00 0.443 0.373 -0.2880 1.170
3.1 0.175 1260.00 0.443 0.290 -0.1250 1.010
3.2 0.124 1580.00 0.443 0.446 -0.4320 1.320

IgG_gp70V1V2C

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00361 0.000724 2.19e-03 0.00503
0.1 0.988 1.26 0.00354 0.000766 2.03e-03 0.00504
0.2 0.988 1.58 0.00354 0.000766 2.03e-03 0.00504
0.3 0.988 2.00 0.00354 0.000766 2.03e-03 0.00504
0.4 0.987 2.51 0.00354 0.000767 2.03e-03 0.00504
0.5 0.985 3.16 0.00354 0.000767 2.03e-03 0.00504
0.6 0.985 3.98 0.00354 0.000767 2.03e-03 0.00504
0.7 0.984 5.01 0.00354 0.000770 2.03e-03 0.00505
0.8 0.984 6.31 0.00354 0.000770 2.03e-03 0.00505
0.9 0.978 7.94 0.00354 0.000771 2.02e-03 0.00505
1.0 0.969 10.00 0.00354 0.000778 2.01e-03 0.00506
1.1 0.962 12.60 0.00354 0.000783 2.00e-03 0.00507
1.2 0.956 15.80 0.00349 0.000768 1.98e-03 0.00499
1.3 0.946 20.00 0.00349 0.000779 1.96e-03 0.00501
1.4 0.936 25.10 0.00323 0.000748 1.76e-03 0.00470
1.5 0.927 31.60 0.00298 0.000716 1.58e-03 0.00438
1.6 0.915 39.80 0.00298 0.000722 1.57e-03 0.00440
1.7 0.899 50.10 0.00298 0.000731 1.55e-03 0.00441
1.8 0.881 63.10 0.00276 0.000706 1.38e-03 0.00415
1.9 0.852 79.40 0.00266 0.000700 1.29e-03 0.00403
2.0 0.830 100.00 0.00260 0.000693 1.24e-03 0.00395
2.1 0.796 126.00 0.00260 0.000721 1.18e-03 0.00401
2.2 0.738 158.00 0.00244 0.000715 1.04e-03 0.00384
2.3 0.678 200.00 0.00243 0.000743 9.80e-04 0.00389
2.4 0.624 251.00 0.00243 0.000812 8.43e-04 0.00403
2.5 0.575 316.00 0.00192 0.000707 5.29e-04 0.00330
2.6 0.533 398.00 0.00179 0.000704 4.12e-04 0.00317
2.7 0.449 501.00 0.00179 0.000739 3.42e-04 0.00324
2.8 0.378 631.00 0.00179 0.000877 7.32e-05 0.00351
2.9 0.304 794.00 0.00179 0.000966 -1.02e-04 0.00368
3.0 0.252 1000.00 0.00179 0.001130 -4.22e-04 0.00400

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 2.10e-03 0.00513
0.1 1.26 0.988 0.00352 0.000766 2.01e-03 0.00502
0.2 1.58 0.988 0.00352 0.000766 2.01e-03 0.00502
0.3 2.00 0.988 0.00352 0.000766 2.01e-03 0.00502
0.4 2.51 0.987 0.00352 0.000767 2.02e-03 0.00502
0.5 3.16 0.985 0.00352 0.000767 2.02e-03 0.00503
0.6 3.98 0.985 0.00352 0.000767 2.02e-03 0.00503
0.7 5.01 0.984 0.00353 0.000770 2.02e-03 0.00504
0.8 6.31 0.984 0.00353 0.000770 2.02e-03 0.00504
0.9 7.94 0.978 0.00355 0.000771 2.04e-03 0.00506
1.0 10.00 0.969 0.00358 0.000778 2.05e-03 0.00510
1.1 12.60 0.962 0.00360 0.000783 2.06e-03 0.00513
1.2 15.80 0.956 0.00346 0.000768 1.96e-03 0.00497
1.3 20.00 0.946 0.00351 0.000779 1.98e-03 0.00504
1.4 25.10 0.936 0.00323 0.000748 1.76e-03 0.00470
1.5 31.60 0.927 0.00295 0.000716 1.55e-03 0.00436
1.6 39.80 0.915 0.00298 0.000722 1.56e-03 0.00439
1.7 50.10 0.899 0.00301 0.000731 1.58e-03 0.00444
1.8 63.10 0.881 0.00276 0.000706 1.38e-03 0.00415
1.9 79.40 0.852 0.00266 0.000700 1.29e-03 0.00403
2.0 100.00 0.830 0.00255 0.000693 1.19e-03 0.00391
2.1 126.00 0.796 0.00264 0.000721 1.23e-03 0.00406
2.2 158.00 0.738 0.00244 0.000715 1.04e-03 0.00384
2.3 200.00 0.678 0.00233 0.000743 8.74e-04 0.00378
2.4 251.00 0.624 0.00254 0.000812 9.53e-04 0.00414
2.5 316.00 0.575 0.00192 0.000707 5.29e-04 0.00330
2.6 398.00 0.533 0.00178 0.000704 4.04e-04 0.00316
2.7 501.00 0.449 0.00159 0.000739 1.43e-04 0.00304
2.8 631.00 0.378 0.00187 0.000877 1.57e-04 0.00359
2.9 794.00 0.304 0.00183 0.000966 -6.63e-05 0.00372
3.0 1000.00 0.252 0.00188 0.001130 -3.34e-04 0.00409

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.220 0.214 -0.1990 0.638
0.1 0.988 1.26 0.236 0.218 -0.1920 0.664
0.2 0.988 1.58 0.236 0.218 -0.1920 0.664
0.3 0.988 2.00 0.236 0.218 -0.1920 0.664
0.4 0.987 2.51 0.236 0.218 -0.1920 0.664
0.5 0.985 3.16 0.236 0.219 -0.1920 0.664
0.6 0.985 3.98 0.236 0.219 -0.1920 0.664
0.7 0.984 5.01 0.236 0.219 -0.1930 0.665
0.8 0.984 6.31 0.236 0.219 -0.1930 0.665
0.9 0.978 7.94 0.236 0.219 -0.1940 0.665
1.0 0.969 10.00 0.236 0.220 -0.1960 0.667
1.1 0.962 12.60 0.236 0.221 -0.1970 0.669
1.2 0.956 15.80 0.247 0.217 -0.1790 0.673
1.3 0.946 20.00 0.247 0.219 -0.1830 0.676
1.4 0.936 25.10 0.302 0.207 -0.1040 0.708
1.5 0.927 31.60 0.356 0.196 -0.0278 0.740
1.6 0.915 39.80 0.356 0.197 -0.0299 0.742
1.7 0.899 50.10 0.356 0.198 -0.0328 0.745
1.8 0.881 63.10 0.403 0.189 0.0333 0.773
1.9 0.852 79.40 0.426 0.185 0.0623 0.789
2.0 0.830 100.00 0.439 0.183 0.0813 0.797
2.1 0.796 126.00 0.439 0.188 0.0715 0.807
2.2 0.738 158.00 0.473 0.183 0.1140 0.832
2.3 0.678 200.00 0.474 0.188 0.1050 0.842
2.4 0.624 251.00 0.474 0.201 0.0799 0.868
2.5 0.575 316.00 0.586 0.171 0.2510 0.922
2.6 0.533 398.00 0.613 0.168 0.2830 0.943
2.7 0.449 501.00 0.613 0.175 0.2690 0.956
2.8 0.378 631.00 0.613 0.203 0.2160 1.010
2.9 0.304 794.00 0.613 0.221 0.1800 1.050
3.0 0.252 1000.00 0.613 0.254 0.1140 1.110

IgG_gp70BCaseA2V1V2169K

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00361 0.000724 2.19e-03 0.00503
0.1 0.998 1.26 0.00349 0.000756 2.00e-03 0.00497
0.2 0.998 1.58 0.00349 0.000756 2.00e-03 0.00497
0.3 0.998 2.00 0.00349 0.000756 2.00e-03 0.00497
0.4 0.997 2.51 0.00349 0.000757 2.00e-03 0.00497
0.5 0.995 3.16 0.00349 0.000758 2.00e-03 0.00497
0.6 0.995 3.98 0.00349 0.000758 2.00e-03 0.00497
0.7 0.994 5.01 0.00349 0.000758 2.00e-03 0.00497
0.8 0.994 6.31 0.00349 0.000758 2.00e-03 0.00497
0.9 0.991 7.94 0.00349 0.000760 2.00e-03 0.00497
1.0 0.989 10.00 0.00349 0.000760 1.99e-03 0.00498
1.1 0.989 12.60 0.00349 0.000760 1.99e-03 0.00498
1.2 0.989 15.80 0.00349 0.000760 1.99e-03 0.00498
1.3 0.982 20.00 0.00349 0.000766 1.98e-03 0.00499
1.4 0.975 25.10 0.00349 0.000769 1.98e-03 0.00499
1.5 0.971 31.60 0.00342 0.000755 1.94e-03 0.00489
1.6 0.967 39.80 0.00342 0.000758 1.93e-03 0.00490
1.7 0.961 50.10 0.00342 0.000763 1.92e-03 0.00491
1.8 0.957 63.10 0.00330 0.000747 1.83e-03 0.00476
1.9 0.941 79.40 0.00321 0.000742 1.75e-03 0.00466
2.0 0.941 100.00 0.00305 0.000722 1.64e-03 0.00447
2.1 0.937 126.00 0.00292 0.000708 1.53e-03 0.00431
2.2 0.920 158.00 0.00282 0.000701 1.44e-03 0.00419
2.3 0.885 200.00 0.00276 0.000699 1.39e-03 0.00413
2.4 0.864 251.00 0.00276 0.000716 1.36e-03 0.00417
2.5 0.827 316.00 0.00256 0.000696 1.19e-03 0.00392
2.6 0.781 398.00 0.00254 0.000717 1.13e-03 0.00394
2.7 0.723 501.00 0.00235 0.000715 9.51e-04 0.00375
2.8 0.675 631.00 0.00217 0.000683 8.27e-04 0.00350
2.9 0.615 794.00 0.00217 0.000758 6.79e-04 0.00365
3.0 0.539 1000.00 0.00217 0.000822 5.55e-04 0.00378
3.1 0.501 1260.00 0.00217 0.000869 4.62e-04 0.00387
3.2 0.399 1580.00 0.00217 0.001110 -1.56e-05 0.00435
3.3 0.337 2000.00 0.00217 0.001260 -3.13e-04 0.00464
3.4 0.263 2510.00 0.00217 0.001400 -5.70e-04 0.00490
3.5 0.207 3160.00 0.00217 0.001990 -1.74e-03 0.00607

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 2.10e-03 0.00513
0.1 1.26 0.998 0.00347 0.000756 1.99e-03 0.00495
0.2 1.58 0.998 0.00347 0.000756 1.99e-03 0.00495
0.3 2.00 0.998 0.00347 0.000756 1.99e-03 0.00495
0.4 2.51 0.997 0.00347 0.000757 1.99e-03 0.00496
0.5 3.16 0.995 0.00348 0.000758 1.99e-03 0.00496
0.6 3.98 0.995 0.00348 0.000758 1.99e-03 0.00496
0.7 5.01 0.994 0.00348 0.000758 1.99e-03 0.00497
0.8 6.31 0.994 0.00348 0.000758 1.99e-03 0.00497
0.9 7.94 0.991 0.00348 0.000760 2.00e-03 0.00497
1.0 10.00 0.989 0.00349 0.000760 2.00e-03 0.00498
1.1 12.60 0.989 0.00349 0.000760 2.00e-03 0.00498
1.2 15.80 0.989 0.00349 0.000760 2.00e-03 0.00498
1.3 20.00 0.982 0.00351 0.000766 2.01e-03 0.00501
1.4 25.10 0.975 0.00352 0.000769 2.02e-03 0.00503
1.5 31.60 0.971 0.00340 0.000755 1.92e-03 0.00488
1.6 39.80 0.967 0.00341 0.000758 1.93e-03 0.00490
1.7 50.10 0.961 0.00344 0.000763 1.94e-03 0.00493
1.8 63.10 0.957 0.00330 0.000747 1.83e-03 0.00476
1.9 79.40 0.941 0.00321 0.000742 1.75e-03 0.00466
2.0 100.00 0.941 0.00305 0.000722 1.64e-03 0.00447
2.1 126.00 0.937 0.00292 0.000708 1.53e-03 0.00431
2.2 158.00 0.920 0.00282 0.000701 1.44e-03 0.00419
2.3 200.00 0.885 0.00273 0.000699 1.36e-03 0.00410
2.4 251.00 0.864 0.00280 0.000716 1.39e-03 0.00420
2.5 316.00 0.827 0.00256 0.000696 1.19e-03 0.00392
2.6 398.00 0.781 0.00254 0.000717 1.13e-03 0.00394
2.7 501.00 0.723 0.00235 0.000715 9.51e-04 0.00375
2.8 631.00 0.675 0.00206 0.000683 7.17e-04 0.00339
2.9 794.00 0.615 0.00228 0.000758 7.91e-04 0.00376
3.0 1000.00 0.539 0.00233 0.000822 7.20e-04 0.00394
3.1 1260.00 0.501 0.00231 0.000869 6.06e-04 0.00401
3.2 1580.00 0.399 0.00268 0.001110 5.03e-04 0.00486
3.3 2000.00 0.337 0.00275 0.001260 2.71e-04 0.00523
3.4 2510.00 0.263 0.00281 0.001400 7.51e-05 0.00554
3.5 3160.00 0.207 0.00350 0.001990 -4.06e-04 0.00741

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.220 0.214 -0.19900 0.638
0.1 0.998 1.26 0.247 0.215 -0.17500 0.669
0.2 0.998 1.58 0.247 0.215 -0.17500 0.669
0.3 0.998 2.00 0.247 0.215 -0.17500 0.669
0.4 0.997 2.51 0.247 0.215 -0.17500 0.669
0.5 0.995 3.16 0.247 0.216 -0.17600 0.669
0.6 0.995 3.98 0.247 0.216 -0.17600 0.669
0.7 0.994 5.01 0.247 0.216 -0.17600 0.670
0.8 0.994 6.31 0.247 0.216 -0.17600 0.670
0.9 0.991 7.94 0.247 0.216 -0.17600 0.670
1.0 0.989 10.00 0.247 0.216 -0.17700 0.670
1.1 0.989 12.60 0.247 0.216 -0.17700 0.670
1.2 0.989 15.80 0.247 0.216 -0.17700 0.670
1.3 0.982 20.00 0.247 0.217 -0.17800 0.672
1.4 0.975 25.10 0.247 0.217 -0.17900 0.673
1.5 0.971 31.60 0.262 0.213 -0.15600 0.680
1.6 0.967 39.80 0.262 0.214 -0.15700 0.681
1.7 0.961 50.10 0.262 0.215 -0.15900 0.683
1.8 0.957 63.10 0.287 0.209 -0.12200 0.697
1.9 0.941 79.40 0.307 0.206 -0.09610 0.711
2.0 0.941 100.00 0.341 0.199 -0.04860 0.730
2.1 0.937 126.00 0.369 0.193 -0.00972 0.747
2.2 0.920 158.00 0.391 0.189 0.02070 0.762
2.3 0.885 200.00 0.403 0.188 0.03480 0.770
2.4 0.864 251.00 0.403 0.191 0.02910 0.776
2.5 0.827 316.00 0.448 0.182 0.09080 0.805
2.6 0.781 398.00 0.452 0.186 0.08820 0.816
2.7 0.723 501.00 0.492 0.181 0.13600 0.847
2.8 0.675 631.00 0.532 0.171 0.19600 0.868
2.9 0.615 794.00 0.532 0.186 0.16800 0.896
3.0 0.539 1000.00 0.532 0.198 0.14400 0.920
3.1 0.501 1260.00 0.532 0.207 0.12600 0.938
3.2 0.399 1580.00 0.532 0.256 0.03090 1.030
3.3 0.337 2000.00 0.532 0.287 -0.03010 1.090
3.4 0.263 2510.00 0.532 0.314 -0.08310 1.150
3.5 0.207 3160.00 0.532 0.440 -0.33000 1.390

IgG_gp70BCaseA2V1V2mut3

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00362 0.000724 0.002200 0.00504
0.1 0.997 1.26 0.00362 0.000774 0.002100 0.00514
0.2 0.997 1.58 0.00362 0.000774 0.002100 0.00514
0.3 0.997 2.00 0.00362 0.000774 0.002100 0.00514
0.4 0.997 2.51 0.00362 0.000774 0.002100 0.00514
0.5 0.997 3.16 0.00362 0.000774 0.002100 0.00514
0.6 0.995 3.98 0.00362 0.000775 0.002100 0.00514
0.7 0.994 5.01 0.00362 0.000776 0.002100 0.00514
0.8 0.994 6.31 0.00362 0.000776 0.002100 0.00514
0.9 0.992 7.94 0.00362 0.000776 0.002100 0.00514
1.0 0.992 10.00 0.00362 0.000776 0.002100 0.00514
1.1 0.992 12.60 0.00362 0.000776 0.002100 0.00514
1.2 0.992 15.80 0.00362 0.000776 0.002100 0.00514
1.3 0.992 20.00 0.00349 0.000759 0.002000 0.00498
1.4 0.992 25.10 0.00349 0.000759 0.002000 0.00498
1.5 0.992 31.60 0.00349 0.000759 0.002000 0.00498
1.6 0.991 39.80 0.00349 0.000760 0.002000 0.00498
1.7 0.991 50.10 0.00349 0.000760 0.002000 0.00498
1.8 0.991 63.10 0.00349 0.000760 0.002000 0.00498
1.9 0.991 79.40 0.00349 0.000760 0.002000 0.00498
2.0 0.991 100.00 0.00349 0.000760 0.002000 0.00498
2.1 0.991 126.00 0.00349 0.000760 0.002000 0.00498
2.2 0.991 158.00 0.00349 0.000760 0.002000 0.00498
2.3 0.989 200.00 0.00349 0.000761 0.002000 0.00498
2.4 0.986 251.00 0.00349 0.000763 0.002000 0.00499
2.5 0.986 316.00 0.00349 0.000763 0.002000 0.00499
2.6 0.986 398.00 0.00349 0.000763 0.002000 0.00499
2.7 0.986 501.00 0.00349 0.000763 0.002000 0.00499
2.8 0.981 631.00 0.00349 0.000765 0.001990 0.00499
2.9 0.981 794.00 0.00349 0.000765 0.001990 0.00499
3.0 0.981 1000.00 0.00342 0.000748 0.001950 0.00488
3.1 0.977 1260.00 0.00342 0.000753 0.001940 0.00489
3.2 0.972 1580.00 0.00342 0.000755 0.001940 0.00490
3.3 0.960 2000.00 0.00342 0.000766 0.001920 0.00492
3.4 0.956 2510.00 0.00342 0.000769 0.001910 0.00492
3.5 0.956 3160.00 0.00331 0.000750 0.001840 0.00478
3.6 0.950 3980.00 0.00318 0.000735 0.001740 0.00462
3.7 0.931 5010.00 0.00300 0.000711 0.001600 0.00439
3.8 0.914 6310.00 0.00300 0.000723 0.001580 0.00441
3.9 0.905 7940.00 0.00300 0.000733 0.001560 0.00443
4.0 0.829 10000.00 0.00300 0.000761 0.001500 0.00449
4.1 0.751 12600.00 0.00300 0.000817 0.001390 0.00460
4.2 0.683 15800.00 0.00298 0.000813 0.001390 0.00457
4.3 0.558 20000.00 0.00298 0.000986 0.001050 0.00491
4.4 0.314 25100.00 0.00298 0.001620 -0.000189 0.00615

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 0.002100 0.00513
0.1 1.26 0.997 0.00362 0.000774 0.002100 0.00514
0.2 1.58 0.997 0.00362 0.000774 0.002100 0.00514
0.3 2.00 0.997 0.00362 0.000774 0.002100 0.00514
0.4 2.51 0.997 0.00362 0.000774 0.002100 0.00514
0.5 3.16 0.997 0.00362 0.000774 0.002100 0.00514
0.6 3.98 0.995 0.00362 0.000775 0.002100 0.00514
0.7 5.01 0.994 0.00362 0.000776 0.002100 0.00514
0.8 6.31 0.994 0.00362 0.000776 0.002100 0.00514
0.9 7.94 0.992 0.00363 0.000776 0.002110 0.00515
1.0 10.00 0.992 0.00363 0.000776 0.002110 0.00515
1.1 12.60 0.992 0.00363 0.000776 0.002110 0.00515
1.2 15.80 0.992 0.00363 0.000776 0.002110 0.00515
1.3 20.00 0.992 0.00348 0.000759 0.001990 0.00497
1.4 25.10 0.992 0.00348 0.000759 0.001990 0.00497
1.5 31.60 0.992 0.00348 0.000759 0.001990 0.00497
1.6 39.80 0.991 0.00348 0.000760 0.002000 0.00497
1.7 50.10 0.991 0.00348 0.000760 0.002000 0.00497
1.8 63.10 0.991 0.00348 0.000760 0.002000 0.00497
1.9 79.40 0.991 0.00348 0.000760 0.002000 0.00497
2.0 100.00 0.991 0.00348 0.000760 0.002000 0.00497
2.1 126.00 0.991 0.00348 0.000760 0.002000 0.00497
2.2 158.00 0.991 0.00348 0.000760 0.002000 0.00497
2.3 200.00 0.989 0.00349 0.000761 0.002000 0.00499
2.4 251.00 0.986 0.00350 0.000763 0.002010 0.00500
2.5 316.00 0.986 0.00350 0.000763 0.002010 0.00500
2.6 398.00 0.986 0.00350 0.000763 0.002010 0.00500
2.7 501.00 0.986 0.00350 0.000763 0.002010 0.00500
2.8 631.00 0.981 0.00351 0.000765 0.002010 0.00501
2.9 794.00 0.981 0.00351 0.000765 0.002010 0.00501
3.0 1000.00 0.981 0.00337 0.000748 0.001900 0.00483
3.1 1260.00 0.977 0.00339 0.000753 0.001920 0.00487
3.2 1580.00 0.972 0.00341 0.000755 0.001930 0.00489
3.3 2000.00 0.960 0.00345 0.000766 0.001950 0.00496
3.4 2510.00 0.956 0.00347 0.000769 0.001960 0.00497
3.5 3160.00 0.956 0.00331 0.000750 0.001840 0.00478
3.6 3980.00 0.950 0.00318 0.000735 0.001740 0.00462
3.7 5010.00 0.931 0.00293 0.000711 0.001540 0.00433
3.8 6310.00 0.914 0.00298 0.000723 0.001560 0.00440
3.9 7940.00 0.905 0.00302 0.000733 0.001580 0.00446
4.0 10000.00 0.829 0.00297 0.000761 0.001480 0.00446
4.1 12600.00 0.751 0.00308 0.000817 0.001480 0.00468
4.2 15800.00 0.683 0.00277 0.000813 0.001180 0.00436
4.3 20000.00 0.558 0.00321 0.000986 0.001270 0.00514
4.4 25100.00 0.314 0.00400 0.001620 0.000831 0.00717

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.217 0.214 -0.2020 0.636
0.1 0.997 1.26 0.217 0.222 -0.2180 0.652
0.2 0.997 1.58 0.217 0.222 -0.2180 0.652
0.3 0.997 2.00 0.217 0.222 -0.2180 0.652
0.4 0.997 2.51 0.217 0.222 -0.2180 0.652
0.5 0.997 3.16 0.217 0.222 -0.2180 0.652
0.6 0.995 3.98 0.217 0.222 -0.2180 0.652
0.7 0.994 5.01 0.217 0.222 -0.2180 0.653
0.8 0.994 6.31 0.217 0.222 -0.2180 0.653
0.9 0.992 7.94 0.217 0.222 -0.2180 0.653
1.0 0.992 10.00 0.217 0.222 -0.2180 0.653
1.1 0.992 12.60 0.217 0.222 -0.2180 0.653
1.2 0.992 15.80 0.217 0.222 -0.2180 0.653
1.3 0.992 20.00 0.245 0.216 -0.1780 0.669
1.4 0.992 25.10 0.245 0.216 -0.1780 0.669
1.5 0.992 31.60 0.245 0.216 -0.1780 0.669
1.6 0.991 39.80 0.245 0.216 -0.1780 0.669
1.7 0.991 50.10 0.245 0.216 -0.1780 0.669
1.8 0.991 63.10 0.245 0.216 -0.1780 0.669
1.9 0.991 79.40 0.245 0.216 -0.1780 0.669
2.0 0.991 100.00 0.245 0.216 -0.1780 0.669
2.1 0.991 126.00 0.245 0.216 -0.1780 0.669
2.2 0.991 158.00 0.245 0.216 -0.1780 0.669
2.3 0.989 200.00 0.245 0.216 -0.1790 0.669
2.4 0.986 251.00 0.245 0.217 -0.1790 0.670
2.5 0.986 316.00 0.245 0.217 -0.1790 0.670
2.6 0.986 398.00 0.245 0.217 -0.1790 0.670
2.7 0.986 501.00 0.245 0.217 -0.1790 0.670
2.8 0.981 631.00 0.245 0.217 -0.1800 0.671
2.9 0.981 794.00 0.245 0.217 -0.1800 0.671
3.0 0.981 1000.00 0.261 0.212 -0.1550 0.677
3.1 0.977 1260.00 0.261 0.213 -0.1560 0.679
3.2 0.972 1580.00 0.261 0.213 -0.1570 0.680
3.3 0.960 2000.00 0.261 0.215 -0.1600 0.683
3.4 0.956 2510.00 0.261 0.216 -0.1610 0.684
3.5 0.956 3160.00 0.284 0.210 -0.1280 0.695
3.6 0.950 3980.00 0.313 0.204 -0.0872 0.713
3.7 0.931 5010.00 0.353 0.195 -0.0300 0.735
3.8 0.914 6310.00 0.353 0.197 -0.0341 0.740
3.9 0.905 7940.00 0.353 0.199 -0.0373 0.743
4.0 0.829 10000.00 0.353 0.204 -0.0470 0.752
4.1 0.751 12600.00 0.353 0.214 -0.0663 0.772
4.2 0.683 15800.00 0.356 0.213 -0.0605 0.773
4.3 0.558 20000.00 0.356 0.244 -0.1230 0.835
4.4 0.314 25100.00 0.356 0.369 -0.3680 1.080

IgG3_A244D11K169

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00362 0.000724 0.002200 0.00504
0.1 0.994 1.26 0.00362 0.000776 0.002100 0.00514
0.2 0.994 1.58 0.00350 0.000759 0.002010 0.00499
0.3 0.994 2.00 0.00350 0.000759 0.002010 0.00499
0.4 0.990 2.51 0.00350 0.000763 0.002000 0.00499
0.5 0.988 3.16 0.00350 0.000764 0.002000 0.00500
0.6 0.988 3.98 0.00350 0.000764 0.002000 0.00500
0.7 0.986 5.01 0.00342 0.000746 0.001960 0.00488
0.8 0.979 6.31 0.00342 0.000750 0.001950 0.00489
0.9 0.979 7.94 0.00342 0.000750 0.001950 0.00489
1.0 0.979 10.00 0.00342 0.000750 0.001950 0.00489
1.1 0.968 12.60 0.00342 0.000756 0.001940 0.00490
1.2 0.962 15.80 0.00342 0.000763 0.001920 0.00491
1.3 0.954 20.00 0.00342 0.000750 0.001950 0.00489
1.4 0.942 25.10 0.00342 0.000762 0.001920 0.00491
1.5 0.924 31.60 0.00342 0.000774 0.001900 0.00494
1.6 0.909 39.80 0.00342 0.000789 0.001870 0.00497
1.7 0.887 50.10 0.00342 0.000787 0.001880 0.00496
1.8 0.851 63.10 0.00342 0.000821 0.001810 0.00503
1.9 0.806 79.40 0.00342 0.000850 0.001750 0.00508
2.0 0.761 100.00 0.00319 0.000820 0.001580 0.00479
2.1 0.676 126.00 0.00317 0.000808 0.001590 0.00476
2.2 0.580 158.00 0.00317 0.000971 0.001270 0.00508
2.3 0.502 200.00 0.00317 0.001100 0.001020 0.00533
2.4 0.370 251.00 0.00317 0.001160 0.000906 0.00544
2.5 0.297 316.00 0.00317 0.001470 0.000301 0.00604
2.6 0.236 398.00 0.00317 0.001830 -0.000414 0.00676
2.7 0.193 501.00 0.00317 0.002150 -0.001030 0.00738
2.8 0.136 631.00 0.00317 0.002720 -0.002160 0.00850
2.9 0.092 794.00 0.00317 0.003120 -0.002930 0.00928

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 0.002100 0.00513
0.1 1.26 0.994 0.00362 0.000776 0.002100 0.00514
0.2 1.58 0.994 0.00348 0.000759 0.001990 0.00497
0.3 2.00 0.994 0.00348 0.000759 0.001990 0.00497
0.4 2.51 0.990 0.00351 0.000763 0.002010 0.00500
0.5 3.16 0.988 0.00351 0.000764 0.002020 0.00501
0.6 3.98 0.988 0.00351 0.000764 0.002020 0.00501
0.7 5.01 0.986 0.00337 0.000746 0.001900 0.00483
0.8 6.31 0.979 0.00339 0.000750 0.001920 0.00486
0.9 7.94 0.979 0.00339 0.000750 0.001920 0.00486
1.0 10.00 0.979 0.00339 0.000750 0.001920 0.00486
1.1 12.60 0.968 0.00341 0.000756 0.001930 0.00489
1.2 15.80 0.962 0.00344 0.000763 0.001940 0.00493
1.3 20.00 0.954 0.00331 0.000750 0.001840 0.00478
1.4 25.10 0.942 0.00337 0.000762 0.001870 0.00486
1.5 31.60 0.924 0.00342 0.000774 0.001900 0.00494
1.6 39.80 0.909 0.00348 0.000789 0.001930 0.00503
1.7 50.10 0.887 0.00339 0.000787 0.001850 0.00494
1.8 63.10 0.851 0.00354 0.000821 0.001930 0.00515
1.9 79.40 0.806 0.00357 0.000850 0.001900 0.00523
2.0 100.00 0.761 0.00319 0.000820 0.001580 0.00479
2.1 126.00 0.676 0.00275 0.000808 0.001170 0.00434
2.2 158.00 0.580 0.00327 0.000971 0.001360 0.00517
2.3 200.00 0.502 0.00355 0.001100 0.001390 0.00570
2.4 251.00 0.370 0.00306 0.001160 0.000795 0.00533
2.5 316.00 0.297 0.00381 0.001470 0.000940 0.00668
2.6 398.00 0.236 0.00438 0.001830 0.000796 0.00797
2.7 501.00 0.193 0.00472 0.002150 0.000519 0.00893
2.8 631.00 0.136 0.00489 0.002720 -0.000440 0.01020
2.9 794.00 0.092 0.00473 0.003120 -0.001380 0.01080

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.218 0.214 -0.201 0.637
0.1 0.994 1.26 0.218 0.222 -0.217 0.653
0.2 0.994 1.58 0.244 0.216 -0.180 0.667
0.3 0.994 2.00 0.244 0.216 -0.180 0.667
0.4 0.990 2.51 0.244 0.217 -0.181 0.669
0.5 0.988 3.16 0.244 0.217 -0.181 0.669
0.6 0.988 3.98 0.244 0.217 -0.181 0.669
0.7 0.986 5.01 0.261 0.212 -0.154 0.677
0.8 0.979 6.31 0.261 0.213 -0.155 0.678
0.9 0.979 7.94 0.261 0.213 -0.155 0.678
1.0 0.979 10.00 0.261 0.213 -0.155 0.678
1.1 0.968 12.60 0.261 0.214 -0.157 0.680
1.2 0.962 15.80 0.261 0.215 -0.160 0.682
1.3 0.954 20.00 0.261 0.213 -0.155 0.678
1.4 0.942 25.10 0.261 0.215 -0.159 0.682
1.5 0.924 31.60 0.261 0.217 -0.163 0.686
1.6 0.909 39.80 0.261 0.219 -0.168 0.691
1.7 0.887 50.10 0.261 0.219 -0.167 0.690
1.8 0.851 63.10 0.261 0.225 -0.179 0.701
1.9 0.806 79.40 0.261 0.229 -0.188 0.711
2.0 0.761 100.00 0.312 0.219 -0.117 0.740
2.1 0.676 126.00 0.314 0.216 -0.109 0.738
2.2 0.580 158.00 0.314 0.246 -0.167 0.796
2.3 0.502 200.00 0.314 0.270 -0.214 0.843
2.4 0.370 251.00 0.314 0.281 -0.236 0.864
2.5 0.297 316.00 0.314 0.341 -0.355 0.983
2.6 0.236 398.00 0.314 0.416 -0.500 1.130
2.7 0.193 501.00 0.314 0.481 -0.628 1.260
2.8 0.136 631.00 0.314 0.601 -0.864 1.490
2.9 0.092 794.00 0.314 0.685 -1.030 1.660

IgG3_gp70ClAEV1V2

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00361 0.000724 0.002190 0.00503
0.1 0.9840 1.26 0.00354 0.000765 0.002040 0.00504
0.2 0.9840 1.58 0.00354 0.000765 0.002040 0.00504
0.3 0.9840 2.00 0.00354 0.000765 0.002040 0.00504
0.4 0.9830 2.51 0.00354 0.000766 0.002040 0.00504
0.5 0.9810 3.16 0.00354 0.000767 0.002040 0.00504
0.6 0.9810 3.98 0.00354 0.000767 0.002040 0.00504
0.7 0.9810 5.01 0.00354 0.000767 0.002040 0.00504
0.8 0.9770 6.31 0.00354 0.000770 0.002030 0.00505
0.9 0.9730 7.94 0.00354 0.000772 0.002030 0.00505
1.0 0.9730 10.00 0.00354 0.000772 0.002030 0.00505
1.1 0.9660 12.60 0.00354 0.000776 0.002020 0.00506
1.2 0.9660 15.80 0.00354 0.000776 0.002020 0.00506
1.3 0.9660 20.00 0.00354 0.000776 0.002020 0.00506
1.4 0.9660 25.10 0.00354 0.000776 0.002020 0.00506
1.5 0.9630 31.60 0.00354 0.000778 0.002010 0.00506
1.6 0.9530 39.80 0.00335 0.000750 0.001880 0.00482
1.7 0.9490 50.10 0.00335 0.000752 0.001880 0.00482
1.8 0.9470 63.10 0.00335 0.000753 0.001870 0.00483
1.9 0.9390 79.40 0.00335 0.000760 0.001860 0.00484
2.0 0.9330 100.00 0.00335 0.000764 0.001850 0.00485
2.1 0.9110 126.00 0.00335 0.000763 0.001850 0.00485
2.2 0.8890 158.00 0.00335 0.000785 0.001810 0.00489
2.3 0.8780 200.00 0.00335 0.000794 0.001790 0.00491
2.4 0.8660 251.00 0.00335 0.000763 0.001860 0.00484
2.5 0.8320 316.00 0.00335 0.000791 0.001800 0.00490
2.6 0.8070 398.00 0.00335 0.000792 0.001800 0.00490
2.7 0.7200 501.00 0.00335 0.000847 0.001690 0.00501
2.8 0.6820 631.00 0.00335 0.000895 0.001590 0.00511
2.9 0.6430 794.00 0.00335 0.000888 0.001610 0.00509
3.0 0.5850 1000.00 0.00335 0.000980 0.001430 0.00527
3.1 0.5130 1260.00 0.00335 0.001050 0.001290 0.00541
3.2 0.4480 1580.00 0.00335 0.001180 0.001050 0.00565
3.3 0.3480 2000.00 0.00335 0.001430 0.000553 0.00615
3.4 0.3010 2510.00 0.00335 0.001630 0.000157 0.00654
3.5 0.2480 3160.00 0.00335 0.001910 -0.000388 0.00709
3.6 0.2030 3980.00 0.00335 0.002040 -0.000658 0.00736
3.7 0.1640 5010.00 0.00335 0.002440 -0.001430 0.00813
3.8 0.1150 6310.00 0.00335 0.002940 -0.002420 0.00912
3.9 0.0801 7940.00 0.00335 0.004710 -0.005880 0.01260
4.0 0.0654 10000.00 0.00335 0.006400 -0.009200 0.01590

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00361 0.000724 0.002100 0.00513
0.1 1.26 0.9840 0.00352 0.000765 0.002020 0.00501
0.2 1.58 0.9840 0.00352 0.000765 0.002020 0.00501
0.3 2.00 0.9840 0.00352 0.000765 0.002020 0.00501
0.4 2.51 0.9830 0.00352 0.000766 0.002020 0.00502
0.5 3.16 0.9810 0.00352 0.000767 0.002020 0.00502
0.6 3.98 0.9810 0.00352 0.000767 0.002020 0.00502
0.7 5.01 0.9810 0.00352 0.000767 0.002020 0.00502
0.8 6.31 0.9770 0.00354 0.000770 0.002030 0.00505
0.9 7.94 0.9730 0.00355 0.000772 0.002030 0.00506
1.0 10.00 0.9730 0.00355 0.000772 0.002030 0.00506
1.1 12.60 0.9660 0.00356 0.000776 0.002040 0.00508
1.2 15.80 0.9660 0.00356 0.000776 0.002040 0.00508
1.3 20.00 0.9660 0.00356 0.000776 0.002040 0.00508
1.4 25.10 0.9660 0.00356 0.000776 0.002040 0.00508
1.5 31.60 0.9630 0.00358 0.000778 0.002050 0.00510
1.6 39.80 0.9530 0.00331 0.000750 0.001840 0.00478
1.7 50.10 0.9490 0.00332 0.000752 0.001850 0.00480
1.8 63.10 0.9470 0.00333 0.000753 0.001850 0.00480
1.9 79.40 0.9390 0.00336 0.000760 0.001870 0.00485
2.0 100.00 0.9330 0.00337 0.000764 0.001870 0.00487
2.1 126.00 0.9110 0.00329 0.000763 0.001800 0.00479
2.2 158.00 0.8890 0.00338 0.000785 0.001840 0.00492
2.3 200.00 0.8780 0.00342 0.000794 0.001860 0.00497
2.4 251.00 0.8660 0.00314 0.000763 0.001640 0.00463
2.5 316.00 0.8320 0.00324 0.000791 0.001690 0.00480
2.6 398.00 0.8070 0.00316 0.000792 0.001610 0.00471
2.7 501.00 0.7200 0.00317 0.000847 0.001510 0.00483
2.8 631.00 0.6820 0.00336 0.000895 0.001600 0.00511
2.9 794.00 0.6430 0.00313 0.000888 0.001390 0.00487
3.0 1000.00 0.5850 0.00343 0.000980 0.001510 0.00536
3.1 1260.00 0.5130 0.00341 0.001050 0.001350 0.00546
3.2 1580.00 0.4480 0.00364 0.001180 0.001340 0.00594
3.3 2000.00 0.3480 0.00418 0.001430 0.001380 0.00697
3.4 2510.00 0.3010 0.00448 0.001630 0.001280 0.00767
3.5 3160.00 0.2480 0.00486 0.001910 0.001120 0.00859
3.6 3980.00 0.2030 0.00456 0.002040 0.000557 0.00857
3.7 5010.00 0.1640 0.00499 0.002440 0.000211 0.00976
3.8 6310.00 0.1150 0.00528 0.002940 -0.000492 0.01100
3.9 7940.00 0.0801 0.00811 0.004710 -0.001120 0.01730
4.0 10000.00 0.0654 0.00987 0.006400 -0.002680 0.02240

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.220 0.214 -0.199 0.638
0.1 0.9840 1.26 0.235 0.218 -0.192 0.663
0.2 0.9840 1.58 0.235 0.218 -0.192 0.663
0.3 0.9840 2.00 0.235 0.218 -0.192 0.663
0.4 0.9830 2.51 0.235 0.218 -0.193 0.663
0.5 0.9810 3.16 0.235 0.218 -0.193 0.663
0.6 0.9810 3.98 0.235 0.218 -0.193 0.663
0.7 0.9810 5.01 0.235 0.218 -0.193 0.663
0.8 0.9770 6.31 0.235 0.219 -0.194 0.664
0.9 0.9730 7.94 0.235 0.219 -0.195 0.665
1.0 0.9730 10.00 0.235 0.219 -0.195 0.665
1.1 0.9660 12.60 0.235 0.220 -0.196 0.666
1.2 0.9660 15.80 0.235 0.220 -0.196 0.666
1.3 0.9660 20.00 0.235 0.220 -0.196 0.666
1.4 0.9660 25.10 0.235 0.220 -0.196 0.666
1.5 0.9630 31.60 0.235 0.220 -0.197 0.667
1.6 0.9530 39.80 0.276 0.211 -0.137 0.689
1.7 0.9490 50.10 0.276 0.211 -0.138 0.690
1.8 0.9470 63.10 0.276 0.211 -0.138 0.690
1.9 0.9390 79.40 0.276 0.213 -0.141 0.693
2.0 0.9330 100.00 0.276 0.213 -0.142 0.694
2.1 0.9110 126.00 0.276 0.213 -0.141 0.694
2.2 0.8890 158.00 0.276 0.217 -0.149 0.701
2.3 0.8780 200.00 0.276 0.218 -0.152 0.704
2.4 0.8660 251.00 0.276 0.213 -0.141 0.693
2.5 0.8320 316.00 0.276 0.218 -0.151 0.703
2.6 0.8070 398.00 0.276 0.218 -0.151 0.703
2.7 0.7200 501.00 0.276 0.227 -0.170 0.722
2.8 0.6820 631.00 0.276 0.236 -0.186 0.738
2.9 0.6430 794.00 0.276 0.235 -0.184 0.736
3.0 0.5850 1000.00 0.276 0.251 -0.216 0.768
3.1 0.5130 1260.00 0.276 0.264 -0.241 0.793
3.2 0.4480 1580.00 0.276 0.288 -0.288 0.840
3.3 0.3480 2000.00 0.276 0.337 -0.384 0.936
3.4 0.3010 2510.00 0.276 0.377 -0.463 1.010
3.5 0.2480 3160.00 0.276 0.434 -0.574 1.130
3.6 0.2030 3980.00 0.276 0.462 -0.629 1.180
3.7 0.1640 5010.00 0.276 0.544 -0.789 1.340
3.8 0.1150 6310.00 0.276 0.650 -0.998 1.550
3.9 0.0801 7940.00 0.276 1.030 -1.740 2.290
4.0 0.0654 10000.00 0.276 1.390 -2.450 3.000

IgG3_gp70V1V2A

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00373 0.000724 0.002310 0.00515
0.1 0.931 1.26 0.00373 0.000820 0.002120 0.00534
0.2 0.923 1.58 0.00373 0.000826 0.002110 0.00535
0.3 0.922 2.00 0.00373 0.000827 0.002110 0.00535
0.4 0.916 2.51 0.00369 0.000813 0.002100 0.00529
0.5 0.914 3.16 0.00369 0.000815 0.002100 0.00529
0.6 0.894 3.98 0.00369 0.000829 0.002070 0.00532
0.7 0.882 5.01 0.00369 0.000837 0.002050 0.00533
0.8 0.867 6.31 0.00364 0.000829 0.002020 0.00527
0.9 0.849 7.94 0.00355 0.000827 0.001930 0.00517
1.0 0.824 10.00 0.00342 0.000779 0.001890 0.00494
1.1 0.778 12.60 0.00342 0.000831 0.001790 0.00505
1.2 0.722 15.80 0.00342 0.000840 0.001770 0.00507
1.3 0.668 20.00 0.00342 0.000910 0.001630 0.00520
1.4 0.565 25.10 0.00342 0.001030 0.001410 0.00543
1.5 0.518 31.60 0.00342 0.001060 0.001330 0.00551
1.6 0.471 39.80 0.00342 0.001130 0.001210 0.00562
1.7 0.385 50.10 0.00342 0.001260 0.000954 0.00588
1.8 0.318 63.10 0.00342 0.001200 0.001070 0.00577
1.9 0.241 79.40 0.00342 0.001690 0.000108 0.00673
2.0 0.213 100.00 0.00342 0.002060 -0.000626 0.00746
2.1 0.179 126.00 0.00342 0.002120 -0.000732 0.00757
2.2 0.122 158.00 0.00342 0.002650 -0.001780 0.00862
2.3 0.113 200.00 0.00342 0.002400 -0.001290 0.00813

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 0.002100 0.00513
0.1 1.26 0.931 0.00376 0.000820 0.002150 0.00536
0.2 1.58 0.923 0.00378 0.000826 0.002160 0.00540
0.3 2.00 0.922 0.00378 0.000827 0.002160 0.00541
0.4 2.51 0.916 0.00365 0.000813 0.002060 0.00525
0.5 3.16 0.914 0.00366 0.000815 0.002060 0.00525
0.6 3.98 0.894 0.00372 0.000829 0.002090 0.00534
0.7 5.01 0.882 0.00375 0.000837 0.002110 0.00539
0.8 6.31 0.867 0.00364 0.000829 0.002020 0.00527
0.9 7.94 0.849 0.00355 0.000827 0.001930 0.00517
1.0 10.00 0.824 0.00312 0.000779 0.001590 0.00464
1.1 12.60 0.778 0.00331 0.000831 0.001680 0.00494
1.2 15.80 0.722 0.00316 0.000840 0.001510 0.00481
1.3 20.00 0.668 0.00341 0.000910 0.001630 0.00520
1.4 25.10 0.565 0.00359 0.001030 0.001580 0.00560
1.5 31.60 0.518 0.00359 0.001060 0.001500 0.00568
1.6 39.80 0.471 0.00364 0.001130 0.001430 0.00584
1.7 50.10 0.385 0.00371 0.001260 0.001250 0.00617
1.8 63.10 0.318 0.00277 0.001200 0.000426 0.00512
1.9 79.40 0.241 0.00353 0.001690 0.000218 0.00684
2.0 100.00 0.213 0.00427 0.002060 0.000222 0.00831
2.1 126.00 0.179 0.00396 0.002120 -0.000188 0.00811
2.2 158.00 0.122 0.00478 0.002650 -0.000423 0.00998
2.3 200.00 0.113 0.00384 0.002400 -0.000872 0.00855

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.194 0.217 -0.232 0.619
0.1 0.931 1.26 0.194 0.232 -0.262 0.649
0.2 0.923 1.58 0.194 0.233 -0.264 0.651
0.3 0.922 2.00 0.194 0.233 -0.264 0.651
0.4 0.916 2.51 0.202 0.230 -0.249 0.653
0.5 0.914 3.16 0.202 0.230 -0.250 0.653
0.6 0.894 3.98 0.202 0.233 -0.254 0.658
0.7 0.882 5.01 0.202 0.234 -0.257 0.661
0.8 0.867 6.31 0.213 0.231 -0.241 0.667
0.9 0.849 7.94 0.232 0.229 -0.216 0.681
1.0 0.824 10.00 0.261 0.217 -0.165 0.687
1.1 0.778 12.60 0.261 0.226 -0.182 0.705
1.2 0.722 15.80 0.261 0.228 -0.185 0.708
1.3 0.668 20.00 0.261 0.240 -0.209 0.732
1.4 0.565 25.10 0.261 0.261 -0.250 0.773
1.5 0.518 31.60 0.261 0.268 -0.264 0.787
1.6 0.471 39.80 0.261 0.279 -0.286 0.809
1.7 0.385 50.10 0.261 0.305 -0.336 0.858
1.8 0.318 63.10 0.261 0.293 -0.313 0.836
1.9 0.241 79.40 0.261 0.390 -0.503 1.030
2.0 0.213 100.00 0.261 0.467 -0.653 1.180
2.1 0.179 126.00 0.261 0.478 -0.675 1.200
2.2 0.122 158.00 0.261 0.590 -0.894 1.420
2.3 0.113 200.00 0.261 0.537 -0.792 1.310

IgG3_gp70V1V2AP

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00370 0.000724 0.002280 0.00512
0.1 0.932 1.26 0.00370 0.000806 0.002120 0.00527
0.2 0.932 1.58 0.00370 0.000806 0.002120 0.00527
0.3 0.916 2.00 0.00370 0.000820 0.002090 0.00530
0.4 0.907 2.51 0.00370 0.000814 0.002100 0.00529
0.5 0.894 3.16 0.00370 0.000822 0.002080 0.00531
0.6 0.871 3.98 0.00370 0.000839 0.002050 0.00534
0.7 0.846 5.01 0.00357 0.000822 0.001950 0.00518
0.8 0.831 6.31 0.00357 0.000839 0.001920 0.00521
0.9 0.787 7.94 0.00340 0.000832 0.001770 0.00504
1.0 0.745 10.00 0.00340 0.000826 0.001790 0.00502
1.1 0.709 12.60 0.00340 0.000874 0.001690 0.00512
1.2 0.648 15.80 0.00340 0.000935 0.001570 0.00524
1.3 0.580 20.00 0.00340 0.000983 0.001480 0.00533
1.4 0.473 25.10 0.00340 0.001110 0.001240 0.00557
1.5 0.413 31.60 0.00337 0.001140 0.001130 0.00561
1.6 0.336 39.80 0.00337 0.001180 0.001050 0.00569
1.7 0.291 50.10 0.00337 0.001300 0.000822 0.00592
1.8 0.219 63.10 0.00337 0.001590 0.000262 0.00648
1.9 0.178 79.40 0.00337 0.002100 -0.000736 0.00748
2.0 0.165 100.00 0.00320 0.001870 -0.000460 0.00686
2.1 0.149 126.00 0.00320 0.002190 -0.001100 0.00750

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 0.002100 0.00513
0.1 1.26 0.932 0.00370 0.000806 0.002120 0.00528
0.2 1.58 0.932 0.00370 0.000806 0.002120 0.00528
0.3 2.00 0.916 0.00376 0.000820 0.002150 0.00537
0.4 2.51 0.907 0.00366 0.000814 0.002060 0.00526
0.5 3.16 0.894 0.00369 0.000822 0.002080 0.00530
0.6 3.98 0.871 0.00376 0.000839 0.002120 0.00541
0.7 5.01 0.846 0.00353 0.000822 0.001920 0.00514
0.8 6.31 0.831 0.00360 0.000839 0.001960 0.00525
0.9 7.94 0.787 0.00340 0.000832 0.001760 0.00503
1.0 10.00 0.745 0.00320 0.000826 0.001580 0.00481
1.1 12.60 0.709 0.00337 0.000874 0.001660 0.00508
1.2 15.80 0.648 0.00350 0.000935 0.001660 0.00533
1.3 20.00 0.580 0.00344 0.000983 0.001520 0.00537
1.4 25.10 0.473 0.00357 0.001110 0.001400 0.00574
1.5 31.60 0.413 0.00337 0.001140 0.001130 0.00561
1.6 39.80 0.336 0.00294 0.001180 0.000623 0.00526
1.7 50.10 0.291 0.00298 0.001300 0.000432 0.00553
1.8 63.10 0.219 0.00333 0.001590 0.000217 0.00643
1.9 79.40 0.178 0.00428 0.002100 0.000173 0.00839
2.0 100.00 0.165 0.00294 0.001870 -0.000723 0.00659
2.1 126.00 0.149 0.00346 0.002190 -0.000840 0.00776

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.201 0.216 -0.222 0.624
0.1 0.932 1.26 0.201 0.229 -0.247 0.650
0.2 0.932 1.58 0.201 0.229 -0.247 0.650
0.3 0.916 2.00 0.201 0.231 -0.252 0.655
0.4 0.907 2.51 0.201 0.230 -0.250 0.653
0.5 0.894 3.16 0.201 0.232 -0.253 0.655
0.6 0.871 3.98 0.201 0.235 -0.258 0.661
0.7 0.846 5.01 0.229 0.228 -0.218 0.677
0.8 0.831 6.31 0.229 0.231 -0.224 0.683
0.9 0.787 7.94 0.264 0.226 -0.179 0.707
1.0 0.745 10.00 0.264 0.225 -0.177 0.705
1.1 0.709 12.60 0.264 0.233 -0.193 0.722
1.2 0.648 15.80 0.264 0.244 -0.214 0.743
1.3 0.580 20.00 0.264 0.253 -0.231 0.760
1.4 0.473 25.10 0.264 0.275 -0.276 0.804
1.5 0.413 31.60 0.272 0.282 -0.280 0.824
1.6 0.336 39.80 0.272 0.289 -0.296 0.839
1.7 0.291 50.10 0.272 0.312 -0.340 0.883
1.8 0.219 63.10 0.272 0.369 -0.451 0.994
1.9 0.178 79.40 0.272 0.473 -0.655 1.200
2.0 0.165 100.00 0.309 0.423 -0.521 1.140
2.1 0.149 126.00 0.309 0.491 -0.654 1.270

IgG3_gp70V1V2C

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00361 0.000724 2.19e-03 0.00503
0.1 0.927 1.26 0.00313 0.000729 1.70e-03 0.00456
0.2 0.922 1.58 0.00313 0.000733 1.70e-03 0.00457
0.3 0.918 2.00 0.00313 0.000736 1.69e-03 0.00458
0.4 0.914 2.51 0.00313 0.000741 1.68e-03 0.00459
0.5 0.907 3.16 0.00313 0.000750 1.66e-03 0.00460
0.6 0.888 3.98 0.00313 0.000746 1.67e-03 0.00460
0.7 0.874 5.01 0.00313 0.000755 1.65e-03 0.00461
0.8 0.851 6.31 0.00313 0.000751 1.66e-03 0.00461
0.9 0.827 7.94 0.00313 0.000773 1.62e-03 0.00465
1.0 0.801 10.00 0.00313 0.000774 1.62e-03 0.00465
1.1 0.753 12.60 0.00313 0.000826 1.51e-03 0.00475
1.2 0.717 15.80 0.00313 0.000838 1.49e-03 0.00478
1.3 0.656 20.00 0.00313 0.000905 1.36e-03 0.00491
1.4 0.605 25.10 0.00313 0.000875 1.42e-03 0.00485
1.5 0.544 31.60 0.00313 0.000973 1.23e-03 0.00504
1.6 0.490 39.80 0.00313 0.001050 1.08e-03 0.00519
1.7 0.444 50.10 0.00313 0.001070 1.04e-03 0.00523
1.8 0.362 63.10 0.00287 0.001160 6.10e-04 0.00514
1.9 0.303 79.40 0.00275 0.001210 3.67e-04 0.00513
2.0 0.274 100.00 0.00275 0.001140 5.20e-04 0.00498
2.1 0.215 126.00 0.00275 0.001440 -7.36e-05 0.00557
2.2 0.180 158.00 0.00275 0.001730 -6.48e-04 0.00614
2.3 0.133 200.00 0.00275 0.002470 -2.10e-03 0.00759

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 0.002100 0.00513
0.1 1.26 0.927 0.00308 0.000729 0.001650 0.00451
0.2 1.58 0.922 0.00309 0.000733 0.001660 0.00453
0.3 2.00 0.918 0.00311 0.000736 0.001660 0.00455
0.4 2.51 0.914 0.00313 0.000741 0.001670 0.00458
0.5 3.16 0.907 0.00316 0.000750 0.001690 0.00463
0.6 3.98 0.888 0.00307 0.000746 0.001610 0.00454
0.7 5.01 0.874 0.00311 0.000755 0.001630 0.00459
0.8 6.31 0.851 0.00301 0.000751 0.001540 0.00448
0.9 7.94 0.827 0.00310 0.000773 0.001580 0.00461
1.0 10.00 0.801 0.00301 0.000774 0.001500 0.00453
1.1 12.60 0.753 0.00321 0.000826 0.001590 0.00483
1.2 15.80 0.717 0.00316 0.000838 0.001520 0.00480
1.3 20.00 0.656 0.00339 0.000905 0.001620 0.00517
1.4 25.10 0.605 0.00297 0.000875 0.001250 0.00468
1.5 31.60 0.544 0.00327 0.000973 0.001360 0.00517
1.6 39.80 0.490 0.00336 0.001050 0.001310 0.00541
1.7 50.10 0.444 0.00313 0.001070 0.001040 0.00523
1.8 63.10 0.362 0.00287 0.001160 0.000610 0.00514
1.9 79.40 0.303 0.00256 0.001210 0.000185 0.00494
2.0 100.00 0.274 0.00190 0.001140 -0.000328 0.00413
2.1 126.00 0.215 0.00239 0.001440 -0.000428 0.00521
2.2 158.00 0.180 0.00287 0.001730 -0.000528 0.00626
2.3 200.00 0.133 0.00401 0.002470 -0.000835 0.00886

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.220 0.214 -0.1990 0.638
0.1 0.927 1.26 0.323 0.202 -0.0728 0.718
0.2 0.922 1.58 0.323 0.202 -0.0740 0.720
0.3 0.918 2.00 0.323 0.203 -0.0749 0.721
0.4 0.914 2.51 0.323 0.204 -0.0767 0.722
0.5 0.907 3.16 0.323 0.205 -0.0796 0.725
0.6 0.888 3.98 0.323 0.205 -0.0785 0.724
0.7 0.874 5.01 0.323 0.206 -0.0814 0.727
0.8 0.851 6.31 0.323 0.206 -0.0800 0.726
0.9 0.827 7.94 0.323 0.209 -0.0873 0.733
1.0 0.801 10.00 0.323 0.209 -0.0876 0.733
1.1 0.753 12.60 0.323 0.219 -0.1050 0.751
1.2 0.717 15.80 0.323 0.221 -0.1100 0.756
1.3 0.656 20.00 0.323 0.233 -0.1330 0.779
1.4 0.605 25.10 0.323 0.227 -0.1230 0.768
1.5 0.544 31.60 0.323 0.245 -0.1580 0.803
1.6 0.490 39.80 0.323 0.259 -0.1850 0.831
1.7 0.444 50.10 0.323 0.263 -0.1930 0.839
1.8 0.362 63.10 0.379 0.275 -0.1610 0.918
1.9 0.303 79.40 0.406 0.285 -0.1520 0.964
2.0 0.274 100.00 0.406 0.269 -0.1220 0.934
2.1 0.215 126.00 0.406 0.330 -0.2410 1.050
2.2 0.180 158.00 0.406 0.390 -0.3590 1.170
2.3 0.133 200.00 0.406 0.546 -0.6630 1.480

IgG3_gp70.V1V2CaseA2

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00361 0.000724 0.002190 0.00503
0.1 0.939 1.26 0.00354 0.000786 0.002000 0.00507
0.2 0.939 1.58 0.00354 0.000786 0.002000 0.00507
0.3 0.934 2.00 0.00339 0.000768 0.001880 0.00489
0.4 0.922 2.51 0.00331 0.000757 0.001830 0.00480
0.5 0.909 3.16 0.00331 0.000767 0.001810 0.00482
0.6 0.891 3.98 0.00331 0.000764 0.001820 0.00481
0.7 0.873 5.01 0.00331 0.000778 0.001790 0.00484
0.8 0.849 6.31 0.00331 0.000799 0.001750 0.00488
0.9 0.821 7.94 0.00331 0.000825 0.001700 0.00493
1.0 0.785 10.00 0.00330 0.000815 0.001710 0.00490
1.1 0.710 12.60 0.00330 0.000866 0.001610 0.00500
1.2 0.656 15.80 0.00330 0.000887 0.001570 0.00504
1.3 0.640 20.00 0.00330 0.000907 0.001530 0.00508
1.4 0.578 25.10 0.00330 0.000974 0.001400 0.00521
1.5 0.487 31.60 0.00322 0.001020 0.001220 0.00522
1.6 0.428 39.80 0.00322 0.001120 0.001030 0.00541
1.7 0.350 50.10 0.00272 0.001100 0.000566 0.00488
1.8 0.312 63.10 0.00272 0.001070 0.000624 0.00483
1.9 0.256 79.40 0.00272 0.001120 0.000521 0.00493
2.0 0.228 100.00 0.00272 0.001380 0.000029 0.00542
2.1 0.161 126.00 0.00272 0.001940 -0.001070 0.00652
2.2 0.122 158.00 0.00272 0.002620 -0.002420 0.00787

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 0.002100 0.00513
0.1 1.26 0.939 0.00354 0.000786 0.002000 0.00507
0.2 1.58 0.939 0.00354 0.000786 0.002000 0.00507
0.3 2.00 0.934 0.00339 0.000768 0.001880 0.00489
0.4 2.51 0.922 0.00327 0.000757 0.001780 0.00475
0.5 3.16 0.909 0.00331 0.000767 0.001810 0.00481
0.6 3.98 0.891 0.00322 0.000764 0.001720 0.00472
0.7 5.01 0.873 0.00328 0.000778 0.001750 0.00480
0.8 6.31 0.849 0.00336 0.000799 0.001790 0.00493
0.9 7.94 0.821 0.00346 0.000825 0.001840 0.00507
1.0 10.00 0.785 0.00325 0.000815 0.001650 0.00484
1.1 12.60 0.710 0.00335 0.000866 0.001650 0.00504
1.2 15.80 0.656 0.00323 0.000887 0.001490 0.00497
1.3 20.00 0.640 0.00330 0.000907 0.001520 0.00508
1.4 25.10 0.578 0.00341 0.000974 0.001500 0.00532
1.5 31.60 0.487 0.00315 0.001020 0.001150 0.00515
1.6 39.80 0.428 0.00330 0.001120 0.001100 0.00549
1.7 50.10 0.350 0.00251 0.001100 0.000355 0.00467
1.8 63.10 0.312 0.00224 0.001070 0.000143 0.00434
1.9 79.40 0.256 0.00188 0.001120 -0.000326 0.00408
2.0 100.00 0.228 0.00229 0.001380 -0.000405 0.00499
2.1 126.00 0.161 0.00319 0.001940 -0.000602 0.00699
2.2 158.00 0.122 0.00423 0.002620 -0.000914 0.00937

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.220 0.214 -0.1990 0.638
0.1 0.939 1.26 0.236 0.221 -0.1980 0.670
0.2 0.939 1.58 0.236 0.221 -0.1980 0.670
0.3 0.934 2.00 0.268 0.215 -0.1530 0.689
0.4 0.922 2.51 0.284 0.211 -0.1300 0.698
0.5 0.909 3.16 0.284 0.213 -0.1330 0.701
0.6 0.891 3.98 0.284 0.212 -0.1320 0.700
0.7 0.873 5.01 0.284 0.215 -0.1370 0.705
0.8 0.849 6.31 0.284 0.218 -0.1440 0.712
0.9 0.821 7.94 0.284 0.223 -0.1520 0.720
1.0 0.785 10.00 0.286 0.221 -0.1470 0.718
1.1 0.710 12.60 0.286 0.230 -0.1640 0.736
1.2 0.656 15.80 0.286 0.233 -0.1710 0.743
1.3 0.640 20.00 0.286 0.237 -0.1780 0.750
1.4 0.578 25.10 0.286 0.249 -0.2020 0.774
1.5 0.487 31.60 0.304 0.255 -0.1970 0.805
1.6 0.428 39.80 0.304 0.274 -0.2330 0.842
1.7 0.350 50.10 0.411 0.262 -0.1020 0.925
1.8 0.312 63.10 0.411 0.256 -0.0911 0.913
1.9 0.256 79.40 0.411 0.267 -0.1110 0.934
2.0 0.228 100.00 0.411 0.317 -0.2100 1.030
2.1 0.161 126.00 0.411 0.432 -0.4360 1.260
2.2 0.122 158.00 0.411 0.578 -0.7210 1.540

IgG3_gp70BCaseA2V1V2169K

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00361 0.000724 0.002190 0.00503
0.1 0.966 1.26 0.00330 0.000741 0.001840 0.00475
0.2 0.966 1.58 0.00330 0.000741 0.001840 0.00475
0.3 0.966 2.00 0.00330 0.000741 0.001840 0.00475
0.4 0.966 2.51 0.00330 0.000741 0.001840 0.00475
0.5 0.964 3.16 0.00330 0.000742 0.001840 0.00475
0.6 0.960 3.98 0.00330 0.000744 0.001840 0.00475
0.7 0.955 5.01 0.00330 0.000748 0.001830 0.00476
0.8 0.932 6.31 0.00330 0.000767 0.001790 0.00480
0.9 0.910 7.94 0.00330 0.000764 0.001800 0.00479
1.0 0.902 10.00 0.00330 0.000769 0.001790 0.00480
1.1 0.889 12.60 0.00321 0.000755 0.001730 0.00469
1.2 0.874 15.80 0.00321 0.000769 0.001700 0.00471
1.3 0.850 20.00 0.00321 0.000767 0.001710 0.00471
1.4 0.825 25.10 0.00321 0.000788 0.001660 0.00475
1.5 0.776 31.60 0.00321 0.000806 0.001630 0.00479
1.6 0.740 39.80 0.00321 0.000795 0.001650 0.00477
1.7 0.687 50.10 0.00321 0.000861 0.001520 0.00489
1.8 0.644 63.10 0.00321 0.000897 0.001450 0.00497
1.9 0.608 79.40 0.00321 0.000887 0.001470 0.00495
2.0 0.530 100.00 0.00321 0.000983 0.001280 0.00513
2.1 0.457 126.00 0.00321 0.001140 0.000980 0.00544
2.2 0.379 158.00 0.00321 0.001170 0.000911 0.00550
2.3 0.325 200.00 0.00321 0.001180 0.000889 0.00553
2.4 0.278 251.00 0.00321 0.001340 0.000588 0.00583
2.5 0.218 316.00 0.00321 0.001470 0.000320 0.00610
2.6 0.168 398.00 0.00321 0.001900 -0.000508 0.00692
2.7 0.127 501.00 0.00321 0.002630 -0.001950 0.00837

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 0.002100 0.00513
0.1 1.26 0.966 0.00327 0.000741 0.001820 0.00473
0.2 1.58 0.966 0.00327 0.000741 0.001820 0.00473
0.3 2.00 0.966 0.00327 0.000741 0.001820 0.00473
0.4 2.51 0.966 0.00327 0.000741 0.001820 0.00473
0.5 3.16 0.964 0.00328 0.000742 0.001820 0.00473
0.6 3.98 0.960 0.00329 0.000744 0.001830 0.00474
0.7 5.01 0.955 0.00331 0.000748 0.001840 0.00477
0.8 6.31 0.932 0.00338 0.000767 0.001880 0.00489
0.9 7.94 0.910 0.00330 0.000764 0.001800 0.00480
1.0 10.00 0.902 0.00332 0.000769 0.001810 0.00482
1.1 12.60 0.889 0.00318 0.000755 0.001700 0.00466
1.2 15.80 0.874 0.00324 0.000769 0.001730 0.00474
1.3 20.00 0.850 0.00315 0.000767 0.001650 0.00465
1.4 25.10 0.825 0.00323 0.000788 0.001690 0.00478
1.5 31.60 0.776 0.00321 0.000806 0.001630 0.00479
1.6 39.80 0.740 0.00299 0.000795 0.001430 0.00455
1.7 50.10 0.687 0.00323 0.000861 0.001540 0.00491
1.8 63.10 0.644 0.00326 0.000897 0.001510 0.00502
1.9 79.40 0.608 0.00301 0.000887 0.001270 0.00475
2.0 100.00 0.530 0.00319 0.000983 0.001270 0.00512
2.1 126.00 0.457 0.00367 0.001140 0.001440 0.00589
2.2 158.00 0.379 0.00312 0.001170 0.000819 0.00541
2.3 200.00 0.325 0.00274 0.001180 0.000422 0.00506
2.4 251.00 0.278 0.00279 0.001340 0.000166 0.00541
2.5 316.00 0.218 0.00273 0.001470 -0.000161 0.00562
2.6 398.00 0.168 0.00349 0.001900 -0.000223 0.00721
2.7 501.00 0.127 0.00466 0.002630 -0.000500 0.00981

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.220 0.214 -0.199 0.638
0.1 0.966 1.26 0.288 0.208 -0.120 0.695
0.2 0.966 1.58 0.288 0.208 -0.120 0.695
0.3 0.966 2.00 0.288 0.208 -0.120 0.695
0.4 0.966 2.51 0.288 0.208 -0.120 0.695
0.5 0.964 3.16 0.288 0.208 -0.120 0.695
0.6 0.960 3.98 0.288 0.208 -0.121 0.696
0.7 0.955 5.01 0.288 0.209 -0.122 0.698
0.8 0.932 6.31 0.288 0.212 -0.128 0.704
0.9 0.910 7.94 0.288 0.212 -0.128 0.703
1.0 0.902 10.00 0.288 0.213 -0.129 0.704
1.1 0.889 12.60 0.307 0.208 -0.101 0.714
1.2 0.874 15.80 0.307 0.210 -0.106 0.719
1.3 0.850 20.00 0.307 0.210 -0.105 0.718
1.4 0.825 25.10 0.307 0.214 -0.112 0.726
1.5 0.776 31.60 0.307 0.217 -0.118 0.732
1.6 0.740 39.80 0.307 0.215 -0.114 0.728
1.7 0.687 50.10 0.307 0.226 -0.137 0.750
1.8 0.644 63.10 0.307 0.233 -0.150 0.763
1.9 0.608 79.40 0.307 0.231 -0.146 0.760
2.0 0.530 100.00 0.307 0.249 -0.180 0.794
2.1 0.457 126.00 0.307 0.277 -0.237 0.851
2.2 0.379 158.00 0.307 0.284 -0.250 0.864
2.3 0.325 200.00 0.307 0.286 -0.255 0.868
2.4 0.278 251.00 0.307 0.316 -0.313 0.927
2.5 0.218 316.00 0.307 0.344 -0.367 0.980
2.6 0.168 398.00 0.307 0.430 -0.535 1.150
2.7 0.127 501.00 0.307 0.583 -0.836 1.450

IgG3_gp70BCaseA2V1V2mut3

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00361 0.000724 2.19e-03 0.00503
0.1 0.9830 1.26 0.00355 0.000766 2.04e-03 0.00505
0.2 0.9830 1.58 0.00355 0.000766 2.04e-03 0.00505
0.3 0.9830 2.00 0.00355 0.000766 2.04e-03 0.00505
0.4 0.9830 2.51 0.00355 0.000766 2.04e-03 0.00505
0.5 0.9810 3.16 0.00355 0.000767 2.04e-03 0.00505
0.6 0.9810 3.98 0.00355 0.000767 2.04e-03 0.00505
0.7 0.9770 5.01 0.00355 0.000770 2.04e-03 0.00505
0.8 0.9770 6.31 0.00355 0.000770 2.04e-03 0.00505
0.9 0.9730 7.94 0.00355 0.000772 2.03e-03 0.00506
1.0 0.9730 10.00 0.00355 0.000772 2.03e-03 0.00506
1.1 0.9660 12.60 0.00355 0.000776 2.02e-03 0.00507
1.2 0.9660 15.80 0.00355 0.000776 2.02e-03 0.00507
1.3 0.9660 20.00 0.00355 0.000776 2.02e-03 0.00507
1.4 0.9570 25.10 0.00355 0.000783 2.01e-03 0.00508
1.5 0.9530 31.60 0.00355 0.000786 2.00e-03 0.00509
1.6 0.9490 39.80 0.00336 0.000752 1.89e-03 0.00484
1.7 0.9490 50.10 0.00336 0.000752 1.89e-03 0.00484
1.8 0.9390 63.10 0.00336 0.000760 1.87e-03 0.00485
1.9 0.9250 79.40 0.00336 0.000769 1.85e-03 0.00487
2.0 0.9110 100.00 0.00336 0.000761 1.87e-03 0.00485
2.1 0.8890 126.00 0.00336 0.000783 1.83e-03 0.00490
2.2 0.8700 158.00 0.00336 0.000778 1.84e-03 0.00489
2.3 0.8460 200.00 0.00336 0.000778 1.84e-03 0.00489
2.4 0.8320 251.00 0.00336 0.000791 1.81e-03 0.00491
2.5 0.8110 316.00 0.00336 0.000787 1.82e-03 0.00490
2.6 0.7360 398.00 0.00336 0.000790 1.81e-03 0.00491
2.7 0.6820 501.00 0.00336 0.000855 1.69e-03 0.00504
2.8 0.6280 631.00 0.00336 0.000905 1.59e-03 0.00513
2.9 0.5600 794.00 0.00336 0.001020 1.37e-03 0.00536
3.0 0.4840 1000.00 0.00336 0.001120 1.17e-03 0.00555
3.1 0.4250 1260.00 0.00336 0.001240 9.24e-04 0.00580
3.2 0.3220 1580.00 0.00336 0.001600 2.17e-04 0.00650
3.3 0.2660 2000.00 0.00336 0.001730 -2.66e-05 0.00675
3.4 0.2400 2510.00 0.00336 0.001930 -4.15e-04 0.00714
3.5 0.1780 3160.00 0.00336 0.002360 -1.27e-03 0.00800
3.6 0.1400 3980.00 0.00336 0.002990 -2.50e-03 0.00922
3.7 0.0991 5010.00 0.00336 0.004080 -4.63e-03 0.01140
3.8 0.0738 6310.00 0.00336 0.005050 -6.53e-03 0.01330

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00361 0.000724 0.002100 0.00513
0.1 1.26 0.9830 0.00352 0.000766 0.002020 0.00502
0.2 1.58 0.9830 0.00352 0.000766 0.002020 0.00502
0.3 2.00 0.9830 0.00352 0.000766 0.002020 0.00502
0.4 2.51 0.9830 0.00352 0.000766 0.002020 0.00502
0.5 3.16 0.9810 0.00352 0.000767 0.002020 0.00502
0.6 3.98 0.9810 0.00352 0.000767 0.002020 0.00502
0.7 5.01 0.9770 0.00354 0.000770 0.002030 0.00505
0.8 6.31 0.9770 0.00354 0.000770 0.002030 0.00505
0.9 7.94 0.9730 0.00355 0.000772 0.002030 0.00506
1.0 10.00 0.9730 0.00355 0.000772 0.002030 0.00506
1.1 12.60 0.9660 0.00356 0.000776 0.002040 0.00508
1.2 15.80 0.9660 0.00356 0.000776 0.002040 0.00508
1.3 20.00 0.9660 0.00356 0.000776 0.002040 0.00508
1.4 25.10 0.9570 0.00360 0.000783 0.002060 0.00513
1.5 31.60 0.9530 0.00361 0.000786 0.002070 0.00515
1.6 39.80 0.9490 0.00332 0.000752 0.001850 0.00480
1.7 50.10 0.9490 0.00332 0.000752 0.001850 0.00480
1.8 63.10 0.9390 0.00336 0.000760 0.001870 0.00485
1.9 79.40 0.9250 0.00340 0.000769 0.001890 0.00490
2.0 100.00 0.9110 0.00329 0.000761 0.001790 0.00478
2.1 126.00 0.8890 0.00337 0.000783 0.001840 0.00491
2.2 158.00 0.8700 0.00328 0.000778 0.001750 0.00480
2.3 200.00 0.8460 0.00319 0.000778 0.001670 0.00472
2.4 251.00 0.8320 0.00324 0.000791 0.001690 0.00480
2.5 316.00 0.8110 0.00314 0.000787 0.001600 0.00468
2.6 398.00 0.7360 0.00288 0.000790 0.001330 0.00443
2.7 501.00 0.6820 0.00311 0.000855 0.001440 0.00479
2.8 631.00 0.6280 0.00318 0.000905 0.001410 0.00496
2.9 794.00 0.5600 0.00356 0.001020 0.001560 0.00555
3.0 1000.00 0.4840 0.00362 0.001120 0.001420 0.00581
3.1 1260.00 0.4250 0.00384 0.001240 0.001400 0.00628
3.2 1580.00 0.3220 0.00466 0.001600 0.001510 0.00780
3.3 2000.00 0.2660 0.00445 0.001730 0.001060 0.00784
3.4 2510.00 0.2400 0.00459 0.001930 0.000814 0.00837
3.5 3160.00 0.1780 0.00524 0.002360 0.000602 0.00987
3.6 3980.00 0.1400 0.00603 0.002990 0.000172 0.01190
3.7 5010.00 0.0991 0.00709 0.004080 -0.000909 0.01510
3.8 6310.00 0.0738 0.00872 0.005050 -0.001170 0.01860

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.220 0.214 -0.199 0.638
0.1 0.9830 1.26 0.234 0.218 -0.194 0.662
0.2 0.9830 1.58 0.234 0.218 -0.194 0.662
0.3 0.9830 2.00 0.234 0.218 -0.194 0.662
0.4 0.9830 2.51 0.234 0.218 -0.194 0.662
0.5 0.9810 3.16 0.234 0.219 -0.195 0.662
0.6 0.9810 3.98 0.234 0.219 -0.195 0.662
0.7 0.9770 5.01 0.234 0.219 -0.196 0.663
0.8 0.9770 6.31 0.234 0.219 -0.196 0.663
0.9 0.9730 7.94 0.234 0.219 -0.196 0.664
1.0 0.9730 10.00 0.234 0.219 -0.196 0.664
1.1 0.9660 12.60 0.234 0.220 -0.198 0.665
1.2 0.9660 15.80 0.234 0.220 -0.198 0.665
1.3 0.9660 20.00 0.234 0.220 -0.198 0.665
1.4 0.9570 25.10 0.234 0.221 -0.200 0.668
1.5 0.9530 31.60 0.234 0.222 -0.201 0.669
1.6 0.9490 39.80 0.274 0.211 -0.141 0.688
1.7 0.9490 50.10 0.274 0.211 -0.141 0.688
1.8 0.9390 63.10 0.274 0.213 -0.143 0.691
1.9 0.9250 79.40 0.274 0.214 -0.146 0.694
2.0 0.9110 100.00 0.274 0.213 -0.144 0.691
2.1 0.8890 126.00 0.274 0.217 -0.151 0.698
2.2 0.8700 158.00 0.274 0.216 -0.149 0.697
2.3 0.8460 200.00 0.274 0.216 -0.149 0.697
2.4 0.8320 251.00 0.274 0.218 -0.154 0.701
2.5 0.8110 316.00 0.274 0.217 -0.152 0.700
2.6 0.7360 398.00 0.274 0.218 -0.153 0.701
2.7 0.6820 501.00 0.274 0.229 -0.175 0.722
2.8 0.6280 631.00 0.274 0.238 -0.192 0.740
2.9 0.5600 794.00 0.274 0.258 -0.232 0.780
3.0 0.4840 1000.00 0.274 0.277 -0.269 0.817
3.1 0.4250 1260.00 0.274 0.301 -0.316 0.863
3.2 0.3220 1580.00 0.274 0.372 -0.456 1.000
3.3 0.2660 2000.00 0.274 0.397 -0.505 1.050
3.4 0.2400 2510.00 0.274 0.438 -0.584 1.130
3.5 0.1780 3160.00 0.274 0.529 -0.762 1.310
3.6 0.1400 3980.00 0.274 0.660 -1.020 1.570
3.7 0.0991 5010.00 0.274 0.892 -1.470 2.020
3.8 0.0738 6310.00 0.274 1.100 -1.880 2.430

IgG_PE_A9004SS_V1_V2_Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00361 0.000724 0.002190 0.00503
0.1 0.993 1.26 0.00325 0.000733 0.001810 0.00468
0.2 0.993 1.58 0.00325 0.000733 0.001810 0.00468
0.3 0.993 2.00 0.00325 0.000733 0.001810 0.00468
0.4 0.993 2.51 0.00325 0.000733 0.001810 0.00468
0.5 0.993 3.16 0.00325 0.000733 0.001810 0.00468
0.6 0.992 3.98 0.00325 0.000734 0.001810 0.00469
0.7 0.990 5.01 0.00325 0.000734 0.001810 0.00469
0.8 0.990 6.31 0.00325 0.000734 0.001810 0.00469
0.9 0.989 7.94 0.00325 0.000736 0.001800 0.00469
1.0 0.989 10.00 0.00325 0.000736 0.001800 0.00469
1.1 0.986 12.60 0.00325 0.000738 0.001800 0.00469
1.2 0.986 15.80 0.00325 0.000738 0.001800 0.00469
1.3 0.986 20.00 0.00325 0.000738 0.001800 0.00469
1.4 0.976 25.10 0.00325 0.000742 0.001790 0.00470
1.5 0.973 31.60 0.00325 0.000744 0.001790 0.00471
1.6 0.969 39.80 0.00301 0.000710 0.001620 0.00440
1.7 0.969 50.10 0.00301 0.000710 0.001620 0.00440
1.8 0.965 63.10 0.00301 0.000715 0.001610 0.00441
1.9 0.964 79.40 0.00287 0.000695 0.001510 0.00424
2.0 0.964 100.00 0.00272 0.000676 0.001400 0.00405
2.1 0.956 126.00 0.00259 0.000659 0.001300 0.00388
2.2 0.947 158.00 0.00259 0.000661 0.001290 0.00389
2.3 0.925 200.00 0.00256 0.000636 0.001320 0.00381
2.4 0.907 251.00 0.00256 0.000648 0.001290 0.00383
2.5 0.873 316.00 0.00256 0.000670 0.001250 0.00387
2.6 0.830 398.00 0.00256 0.000703 0.001180 0.00394
2.7 0.769 501.00 0.00256 0.000762 0.001070 0.00405
2.8 0.716 631.00 0.00256 0.000796 0.001000 0.00412
2.9 0.673 794.00 0.00236 0.000746 0.000897 0.00382
3.0 0.614 1000.00 0.00236 0.000788 0.000814 0.00390
3.1 0.536 1260.00 0.00236 0.000808 0.000774 0.00394
3.2 0.489 1580.00 0.00236 0.000887 0.000621 0.00410
3.3 0.377 2000.00 0.00236 0.001070 0.000266 0.00445
3.4 0.302 2510.00 0.00236 0.001450 -0.000475 0.00519
3.5 0.213 3160.00 0.00236 0.001730 -0.001030 0.00574

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 0.002010 0.00502
0.1 1.26 0.993 0.00323 0.000733 0.001800 0.00467
0.2 1.58 0.993 0.00323 0.000733 0.001800 0.00467
0.3 2.00 0.993 0.00323 0.000733 0.001800 0.00467
0.4 2.51 0.993 0.00323 0.000733 0.001800 0.00467
0.5 3.16 0.993 0.00323 0.000733 0.001800 0.00467
0.6 3.98 0.992 0.00324 0.000734 0.001800 0.00468
0.7 5.01 0.990 0.00324 0.000734 0.001800 0.00468
0.8 6.31 0.990 0.00324 0.000734 0.001800 0.00468
0.9 7.94 0.989 0.00325 0.000736 0.001810 0.00469
1.0 10.00 0.989 0.00325 0.000736 0.001810 0.00469
1.1 12.60 0.986 0.00326 0.000738 0.001810 0.00470
1.2 15.80 0.986 0.00326 0.000738 0.001810 0.00470
1.3 20.00 0.986 0.00326 0.000738 0.001810 0.00470
1.4 25.10 0.976 0.00328 0.000742 0.001820 0.00473
1.5 31.60 0.973 0.00328 0.000744 0.001830 0.00474
1.6 39.80 0.969 0.00300 0.000710 0.001610 0.00439
1.7 50.10 0.969 0.00300 0.000710 0.001610 0.00439
1.8 63.10 0.965 0.00302 0.000715 0.001620 0.00443
1.9 79.40 0.964 0.00287 0.000695 0.001510 0.00424
2.0 100.00 0.964 0.00272 0.000676 0.001400 0.00405
2.1 126.00 0.956 0.00259 0.000659 0.001290 0.00388
2.2 158.00 0.947 0.00260 0.000661 0.001300 0.00389
2.3 200.00 0.925 0.00235 0.000636 0.001100 0.00359
2.4 251.00 0.907 0.00239 0.000648 0.001120 0.00366
2.5 316.00 0.873 0.00247 0.000670 0.001160 0.00378
2.6 398.00 0.830 0.00258 0.000703 0.001210 0.00396
2.7 501.00 0.769 0.00280 0.000762 0.001300 0.00429
2.8 631.00 0.716 0.00282 0.000796 0.001260 0.00438
2.9 794.00 0.673 0.00235 0.000746 0.000890 0.00381
3.0 1000.00 0.614 0.00237 0.000788 0.000821 0.00391
3.1 1260.00 0.536 0.00217 0.000808 0.000582 0.00375
3.2 1580.00 0.489 0.00237 0.000887 0.000630 0.00411
3.3 2000.00 0.377 0.00241 0.001070 0.000315 0.00450
3.4 2510.00 0.302 0.00289 0.001450 0.000058 0.00573
3.5 3160.00 0.213 0.00275 0.001730 -0.000630 0.00614

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.220 0.214 -0.19900 0.638
0.1 0.993 1.26 0.298 0.205 -0.10400 0.701
0.2 0.993 1.58 0.298 0.205 -0.10400 0.701
0.3 0.993 2.00 0.298 0.205 -0.10400 0.701
0.4 0.993 2.51 0.298 0.205 -0.10400 0.701
0.5 0.993 3.16 0.298 0.205 -0.10400 0.701
0.6 0.992 3.98 0.298 0.205 -0.10500 0.701
0.7 0.990 5.01 0.298 0.206 -0.10500 0.701
0.8 0.990 6.31 0.298 0.206 -0.10500 0.701
0.9 0.989 7.94 0.298 0.206 -0.10500 0.702
1.0 0.989 10.00 0.298 0.206 -0.10500 0.702
1.1 0.986 12.60 0.298 0.206 -0.10600 0.702
1.2 0.986 15.80 0.298 0.206 -0.10600 0.702
1.3 0.986 20.00 0.298 0.206 -0.10600 0.702
1.4 0.976 25.10 0.298 0.207 -0.10700 0.704
1.5 0.973 31.60 0.298 0.207 -0.10800 0.704
1.6 0.969 39.80 0.350 0.195 -0.03330 0.733
1.7 0.969 50.10 0.350 0.195 -0.03330 0.733
1.8 0.965 63.10 0.350 0.196 -0.03510 0.734
1.9 0.964 79.40 0.379 0.190 0.00764 0.751
2.0 0.964 100.00 0.411 0.183 0.05360 0.769
2.1 0.956 126.00 0.440 0.176 0.09430 0.786
2.2 0.947 158.00 0.440 0.177 0.09330 0.787
2.3 0.925 200.00 0.447 0.172 0.11000 0.783
2.4 0.907 251.00 0.447 0.174 0.10600 0.787
2.5 0.873 316.00 0.447 0.178 0.09830 0.795
2.6 0.830 398.00 0.447 0.184 0.08670 0.807
2.7 0.769 501.00 0.447 0.194 0.06600 0.827
2.8 0.716 631.00 0.447 0.201 0.05350 0.840
2.9 0.673 794.00 0.490 0.187 0.12400 0.857
3.0 0.614 1000.00 0.490 0.195 0.10800 0.872
3.1 0.536 1260.00 0.490 0.199 0.10000 0.880
3.2 0.489 1580.00 0.490 0.214 0.07110 0.909
3.3 0.377 2000.00 0.490 0.250 0.00114 0.979
3.4 0.302 2510.00 0.490 0.327 -0.15000 1.130
3.5 0.213 3160.00 0.490 0.385 -0.26500 1.240

IgG_PE_AQ23_V1_V2_Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00361 0.000724 0.002190 0.00503
0.1 0.995 1.26 0.00342 0.000760 0.001930 0.00491
0.2 0.994 1.58 0.00342 0.000760 0.001930 0.00491
0.3 0.994 2.00 0.00342 0.000760 0.001930 0.00491
0.4 0.989 2.51 0.00342 0.000762 0.001930 0.00492
0.5 0.989 3.16 0.00342 0.000762 0.001930 0.00492
0.6 0.989 3.98 0.00342 0.000762 0.001930 0.00492
0.7 0.989 5.01 0.00331 0.000744 0.001850 0.00477
0.8 0.988 6.31 0.00331 0.000745 0.001850 0.00477
0.9 0.986 7.94 0.00331 0.000746 0.001850 0.00477
1.0 0.985 10.00 0.00331 0.000746 0.001840 0.00477
1.1 0.983 12.60 0.00331 0.000747 0.001840 0.00477
1.2 0.977 15.80 0.00331 0.000751 0.001840 0.00478
1.3 0.974 20.00 0.00331 0.000753 0.001830 0.00478
1.4 0.969 25.10 0.00331 0.000756 0.001830 0.00479
1.5 0.969 31.60 0.00331 0.000756 0.001830 0.00479
1.6 0.960 39.80 0.00321 0.000744 0.001750 0.00467
1.7 0.960 50.10 0.00306 0.000724 0.001640 0.00448
1.8 0.950 63.10 0.00264 0.000671 0.001330 0.00396
1.9 0.935 79.40 0.00264 0.000680 0.001310 0.00398
2.0 0.922 100.00 0.00253 0.000664 0.001230 0.00384
2.1 0.914 126.00 0.00253 0.000668 0.001220 0.00384
2.2 0.893 158.00 0.00235 0.000640 0.001100 0.00361
2.3 0.875 200.00 0.00235 0.000653 0.001080 0.00363
2.4 0.837 251.00 0.00235 0.000658 0.001070 0.00364
2.5 0.786 316.00 0.00235 0.000698 0.000987 0.00372
2.6 0.758 398.00 0.00235 0.000724 0.000935 0.00377
2.7 0.710 501.00 0.00235 0.000730 0.000923 0.00379
2.8 0.648 631.00 0.00226 0.000754 0.000777 0.00373
2.9 0.585 794.00 0.00226 0.000817 0.000653 0.00386
3.0 0.519 1000.00 0.00226 0.000883 0.000525 0.00398
3.1 0.469 1260.00 0.00226 0.000878 0.000534 0.00398
3.2 0.371 1580.00 0.00226 0.000977 0.000340 0.00417
3.3 0.298 2000.00 0.00226 0.001320 -0.000338 0.00485

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 2.03e-03 0.00507
0.1 1.26 0.995 0.00341 0.000760 1.93e-03 0.00490
0.2 1.58 0.994 0.00342 0.000760 1.93e-03 0.00491
0.3 2.00 0.994 0.00342 0.000760 1.93e-03 0.00491
0.4 2.51 0.989 0.00343 0.000762 1.94e-03 0.00493
0.5 3.16 0.989 0.00343 0.000762 1.94e-03 0.00493
0.6 3.98 0.989 0.00343 0.000762 1.94e-03 0.00493
0.7 5.01 0.989 0.00328 0.000744 1.82e-03 0.00474
0.8 6.31 0.988 0.00329 0.000745 1.83e-03 0.00475
0.9 7.94 0.986 0.00329 0.000746 1.83e-03 0.00476
1.0 10.00 0.985 0.00330 0.000746 1.83e-03 0.00476
1.1 12.60 0.983 0.00330 0.000747 1.84e-03 0.00477
1.2 15.80 0.977 0.00332 0.000751 1.85e-03 0.00479
1.3 20.00 0.974 0.00332 0.000753 1.85e-03 0.00480
1.4 25.10 0.969 0.00333 0.000756 1.85e-03 0.00482
1.5 31.60 0.969 0.00333 0.000756 1.85e-03 0.00482
1.6 39.80 0.960 0.00321 0.000744 1.75e-03 0.00467
1.7 50.10 0.960 0.00306 0.000724 1.64e-03 0.00448
1.8 63.10 0.950 0.00263 0.000671 1.31e-03 0.00394
1.9 79.40 0.935 0.00266 0.000680 1.33e-03 0.00400
2.0 100.00 0.922 0.00253 0.000664 1.23e-03 0.00383
2.1 126.00 0.914 0.00254 0.000668 1.23e-03 0.00385
2.2 158.00 0.893 0.00228 0.000640 1.03e-03 0.00354
2.3 200.00 0.875 0.00233 0.000653 1.05e-03 0.00361
2.4 251.00 0.837 0.00226 0.000658 9.70e-04 0.00355
2.5 316.00 0.786 0.00239 0.000698 1.02e-03 0.00376
2.6 398.00 0.758 0.00248 0.000724 1.06e-03 0.00390
2.7 501.00 0.710 0.00240 0.000730 9.71e-04 0.00383
2.8 631.00 0.648 0.00225 0.000754 7.77e-04 0.00373
2.9 794.00 0.585 0.00232 0.000817 7.17e-04 0.00392
3.0 1000.00 0.519 0.00235 0.000883 6.25e-04 0.00408
3.1 1260.00 0.469 0.00219 0.000878 4.67e-04 0.00391
3.2 1580.00 0.371 0.00206 0.000977 1.45e-04 0.00397
3.3 2000.00 0.298 0.00269 0.001320 9.59e-05 0.00528

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.220 0.214 -0.1990 0.638
0.1 0.995 1.26 0.260 0.214 -0.1600 0.680
0.2 0.994 1.58 0.260 0.214 -0.1600 0.680
0.3 0.994 2.00 0.260 0.214 -0.1600 0.680
0.4 0.989 2.51 0.260 0.215 -0.1610 0.681
0.5 0.989 3.16 0.260 0.215 -0.1610 0.681
0.6 0.989 3.98 0.260 0.215 -0.1610 0.681
0.7 0.989 5.01 0.285 0.209 -0.1240 0.694
0.8 0.988 6.31 0.285 0.209 -0.1240 0.695
0.9 0.986 7.94 0.285 0.209 -0.1240 0.695
1.0 0.985 10.00 0.285 0.209 -0.1250 0.695
1.1 0.983 12.60 0.285 0.209 -0.1250 0.695
1.2 0.977 15.80 0.285 0.210 -0.1260 0.697
1.3 0.974 20.00 0.285 0.210 -0.1270 0.697
1.4 0.969 25.10 0.285 0.211 -0.1280 0.698
1.5 0.969 31.60 0.285 0.211 -0.1280 0.698
1.6 0.960 39.80 0.306 0.206 -0.0980 0.710
1.7 0.960 50.10 0.339 0.199 -0.0513 0.729
1.8 0.950 63.10 0.428 0.180 0.0760 0.781
1.9 0.935 79.40 0.428 0.181 0.0728 0.784
2.0 0.922 100.00 0.452 0.176 0.1070 0.797
2.1 0.914 126.00 0.452 0.177 0.1060 0.799
2.2 0.893 158.00 0.491 0.168 0.1620 0.820
2.3 0.875 200.00 0.491 0.170 0.1580 0.824
2.4 0.837 251.00 0.491 0.171 0.1560 0.826
2.5 0.786 316.00 0.491 0.178 0.1420 0.840
2.6 0.758 398.00 0.491 0.183 0.1320 0.850
2.7 0.710 501.00 0.491 0.184 0.1300 0.852
2.8 0.648 631.00 0.513 0.187 0.1470 0.878
2.9 0.585 794.00 0.513 0.199 0.1230 0.902
3.0 0.519 1000.00 0.513 0.211 0.0987 0.927
3.1 0.469 1260.00 0.513 0.210 0.1000 0.925
3.2 0.371 1580.00 0.513 0.230 0.0622 0.963
3.3 0.298 2000.00 0.513 0.300 -0.0752 1.100

IgG_PE_BioRV144_V2_AE

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00361 0.000724 0.002190 0.00503
0.1 0.9740 1.26 0.00329 0.000743 0.001830 0.00474
0.2 0.9740 1.58 0.00316 0.000725 0.001740 0.00458
0.3 0.9740 2.00 0.00316 0.000725 0.001740 0.00458
0.4 0.9740 2.51 0.00316 0.000725 0.001740 0.00458
0.5 0.9740 3.16 0.00316 0.000725 0.001740 0.00458
0.6 0.9740 3.98 0.00316 0.000725 0.001740 0.00458
0.7 0.9670 5.01 0.00316 0.000727 0.001740 0.00459
0.8 0.9660 6.31 0.00316 0.000728 0.001740 0.00459
0.9 0.9530 7.94 0.00316 0.000739 0.001710 0.00461
1.0 0.9520 10.00 0.00316 0.000740 0.001710 0.00461
1.1 0.9320 12.60 0.00316 0.000752 0.001690 0.00464
1.2 0.9090 15.80 0.00316 0.000748 0.001690 0.00462
1.3 0.8990 20.00 0.00302 0.000733 0.001580 0.00446
1.4 0.8760 25.10 0.00279 0.000714 0.001390 0.00419
1.5 0.8390 31.60 0.00276 0.000715 0.001360 0.00416
1.6 0.8090 39.80 0.00276 0.000739 0.001310 0.00421
1.7 0.7800 50.10 0.00269 0.000733 0.001250 0.00412
1.8 0.7130 63.10 0.00232 0.000706 0.000939 0.00371
1.9 0.6660 79.40 0.00230 0.000729 0.000870 0.00373
2.0 0.6130 100.00 0.00230 0.000675 0.000976 0.00362
2.1 0.5840 126.00 0.00230 0.000644 0.001040 0.00356
2.2 0.4970 158.00 0.00230 0.000761 0.000808 0.00379
2.3 0.4330 200.00 0.00230 0.000882 0.000572 0.00403
2.4 0.3770 251.00 0.00230 0.001030 0.000290 0.00431
2.5 0.3120 316.00 0.00230 0.000987 0.000365 0.00423
2.6 0.2590 398.00 0.00230 0.000859 0.000615 0.00398
2.7 0.2180 501.00 0.00230 0.000959 0.000420 0.00418
2.8 0.1770 631.00 0.00230 0.001270 -0.000192 0.00479
2.9 0.1390 794.00 0.00230 0.001510 -0.000657 0.00526
3.0 0.1030 1000.00 0.00230 0.001930 -0.001480 0.00608
3.1 0.0622 1260.00 0.00230 0.003730 -0.005010 0.00961
3.2 0.0568 1580.00 0.00230 0.004040 -0.005620 0.01020

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00361 0.000724 0.002000 0.00499
0.1 1.26 0.9740 0.00329 0.000743 0.001830 0.00474
0.2 1.58 0.9740 0.00314 0.000725 0.001720 0.00456
0.3 2.00 0.9740 0.00314 0.000725 0.001720 0.00456
0.4 2.51 0.9740 0.00314 0.000725 0.001720 0.00456
0.5 3.16 0.9740 0.00314 0.000725 0.001720 0.00456
0.6 3.98 0.9740 0.00314 0.000725 0.001720 0.00456
0.7 5.01 0.9670 0.00315 0.000727 0.001720 0.00457
0.8 6.31 0.9660 0.00315 0.000728 0.001720 0.00458
0.9 7.94 0.9530 0.00320 0.000739 0.001750 0.00465
1.0 10.00 0.9520 0.00320 0.000740 0.001750 0.00465
1.1 12.60 0.9320 0.00325 0.000752 0.001780 0.00473
1.2 15.80 0.9090 0.00316 0.000748 0.001690 0.00462
1.3 20.00 0.8990 0.00302 0.000733 0.001580 0.00446
1.4 25.10 0.8760 0.00279 0.000714 0.001390 0.00419
1.5 31.60 0.8390 0.00271 0.000715 0.001310 0.00411
1.6 39.80 0.8090 0.00280 0.000739 0.001350 0.00425
1.7 50.10 0.7800 0.00269 0.000733 0.001250 0.00412
1.8 63.10 0.7130 0.00232 0.000706 0.000939 0.00371
1.9 79.40 0.6660 0.00230 0.000729 0.000866 0.00373
2.0 100.00 0.6130 0.00193 0.000675 0.000606 0.00325
2.1 126.00 0.5840 0.00174 0.000644 0.000476 0.00300
2.2 158.00 0.4970 0.00191 0.000761 0.000419 0.00340
2.3 200.00 0.4330 0.00221 0.000882 0.000483 0.00394
2.4 251.00 0.3770 0.00255 0.001030 0.000541 0.00456
2.5 316.00 0.3120 0.00207 0.000987 0.000139 0.00401
2.6 398.00 0.2590 0.00143 0.000859 -0.000259 0.00311
2.7 501.00 0.2180 0.00155 0.000959 -0.000329 0.00343
2.8 631.00 0.1770 0.00205 0.001270 -0.000442 0.00454
2.9 794.00 0.1390 0.00247 0.001510 -0.000489 0.00542
3.0 1000.00 0.1030 0.00310 0.001930 -0.000679 0.00689
3.1 1260.00 0.0622 0.00555 0.003730 -0.001760 0.01290
3.2 1580.00 0.0568 0.00630 0.004040 -0.001620 0.01420

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.220 0.214 -0.1990 0.638
0.1 0.9740 1.26 0.290 0.208 -0.1180 0.698
0.2 0.9740 1.58 0.316 0.202 -0.0793 0.712
0.3 0.9740 2.00 0.316 0.202 -0.0793 0.712
0.4 0.9740 2.51 0.316 0.202 -0.0793 0.712
0.5 0.9740 3.16 0.316 0.202 -0.0793 0.712
0.6 0.9740 3.98 0.316 0.202 -0.0793 0.712
0.7 0.9670 5.01 0.316 0.202 -0.0802 0.713
0.8 0.9660 6.31 0.316 0.202 -0.0804 0.713
0.9 0.9530 7.94 0.316 0.204 -0.0842 0.717
1.0 0.9520 10.00 0.316 0.204 -0.0845 0.717
1.1 0.9320 12.60 0.316 0.207 -0.0885 0.721
1.2 0.9090 15.80 0.318 0.205 -0.0848 0.721
1.3 0.8990 20.00 0.347 0.200 -0.0440 0.739
1.4 0.8760 25.10 0.397 0.191 0.0227 0.771
1.5 0.8390 31.60 0.404 0.190 0.0316 0.777
1.6 0.8090 39.80 0.404 0.194 0.0232 0.786
1.7 0.7800 50.10 0.419 0.192 0.0431 0.795
1.8 0.7130 63.10 0.498 0.179 0.1480 0.849
1.9 0.6660 79.40 0.503 0.183 0.1450 0.861
2.0 0.6130 100.00 0.503 0.173 0.1640 0.842
2.1 0.5840 126.00 0.503 0.167 0.1750 0.831
2.2 0.4970 158.00 0.503 0.189 0.1330 0.873
2.3 0.4330 200.00 0.503 0.212 0.0879 0.918
2.4 0.3770 251.00 0.503 0.240 0.0324 0.974
2.5 0.3120 316.00 0.503 0.233 0.0472 0.959
2.6 0.2590 398.00 0.503 0.207 0.0964 0.910
2.7 0.2180 501.00 0.503 0.227 0.0581 0.948
2.8 0.1770 631.00 0.503 0.290 -0.0652 1.070
2.9 0.1390 794.00 0.503 0.339 -0.1610 1.170
3.0 0.1030 1000.00 0.503 0.427 -0.3350 1.340
3.1 0.0622 1260.00 0.503 0.811 -1.0900 2.090
3.2 0.0568 1580.00 0.503 0.878 -1.2200 2.220

IgG_PE_BioRV144_V2_B

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00384 0.000724 0.002420 0.00526
0.1 0.842 1.26 0.00384 0.000854 0.002170 0.00552
0.2 0.838 1.58 0.00384 0.000858 0.002160 0.00553
0.3 0.828 2.00 0.00384 0.000871 0.002140 0.00555
0.4 0.790 2.51 0.00384 0.000921 0.002040 0.00565
0.5 0.774 3.16 0.00384 0.000940 0.002000 0.00569
0.6 0.769 3.98 0.00384 0.000945 0.001990 0.00570
0.7 0.755 5.01 0.00384 0.000938 0.002010 0.00568
0.8 0.717 6.31 0.00384 0.000963 0.001960 0.00573
0.9 0.698 7.94 0.00384 0.000990 0.001900 0.00578
1.0 0.685 10.00 0.00384 0.000978 0.001930 0.00576
1.1 0.651 12.60 0.00346 0.000935 0.001630 0.00529
1.2 0.584 15.80 0.00346 0.000996 0.001510 0.00541
1.3 0.543 20.00 0.00346 0.001040 0.001420 0.00550
1.4 0.499 25.10 0.00333 0.001040 0.001300 0.00536
1.5 0.462 31.60 0.00333 0.001110 0.001150 0.00551
1.6 0.414 39.80 0.00287 0.001080 0.000751 0.00499
1.7 0.358 50.10 0.00283 0.001140 0.000598 0.00507
1.8 0.281 63.10 0.00280 0.001330 0.000202 0.00540
1.9 0.241 79.40 0.00264 0.001400 -0.000104 0.00538

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00361 0.000724 0.002150 0.00526
0.1 1.26 0.842 0.00367 0.000854 0.001990 0.00534
0.2 1.58 0.838 0.00368 0.000858 0.002000 0.00536
0.3 2.00 0.828 0.00374 0.000871 0.002030 0.00544
0.4 2.51 0.790 0.00393 0.000921 0.002130 0.00574
0.5 3.16 0.774 0.00401 0.000940 0.002170 0.00585
0.6 3.98 0.769 0.00403 0.000945 0.002180 0.00588
0.7 5.01 0.755 0.00391 0.000938 0.002070 0.00575
0.8 6.31 0.717 0.00391 0.000963 0.002020 0.00580
0.9 7.94 0.698 0.00401 0.000990 0.002070 0.00595
1.0 10.00 0.685 0.00386 0.000978 0.001940 0.00577
1.1 12.60 0.651 0.00339 0.000935 0.001550 0.00522
1.2 15.80 0.584 0.00349 0.000996 0.001530 0.00544
1.3 20.00 0.543 0.00351 0.001040 0.001470 0.00555
1.4 25.10 0.499 0.00323 0.001040 0.001200 0.00526
1.5 31.60 0.462 0.00344 0.001110 0.001260 0.00562
1.6 39.80 0.414 0.00287 0.001080 0.000751 0.00499
1.7 50.10 0.358 0.00283 0.001140 0.000598 0.00507
1.8 63.10 0.281 0.00280 0.001330 0.000202 0.00540
1.9 79.40 0.241 0.00264 0.001400 -0.000104 0.00538

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.169 0.220 -0.262 0.601
0.1 0.842 1.26 0.169 0.241 -0.303 0.641
0.2 0.838 1.58 0.169 0.241 -0.304 0.643
0.3 0.828 2.00 0.169 0.244 -0.308 0.647
0.4 0.790 2.51 0.169 0.252 -0.325 0.663
0.5 0.774 3.16 0.169 0.255 -0.331 0.670
0.6 0.769 3.98 0.169 0.256 -0.333 0.671
0.7 0.755 5.01 0.169 0.255 -0.330 0.669
0.8 0.717 6.31 0.169 0.259 -0.339 0.678
0.9 0.698 7.94 0.169 0.264 -0.348 0.687
1.0 0.685 10.00 0.169 0.262 -0.344 0.683
1.1 0.651 12.60 0.253 0.245 -0.228 0.734
1.2 0.584 15.80 0.253 0.256 -0.250 0.755
1.3 0.543 20.00 0.253 0.264 -0.265 0.771
1.4 0.499 25.10 0.280 0.261 -0.232 0.792
1.5 0.462 31.60 0.280 0.275 -0.260 0.819
1.6 0.414 39.80 0.379 0.261 -0.132 0.891
1.7 0.358 50.10 0.388 0.271 -0.144 0.920
1.8 0.281 63.10 0.394 0.308 -0.210 0.998
1.9 0.241 79.40 0.430 0.320 -0.198 1.060

IgG_PE_BioRV144_V2_C

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00361 0.000724 2.19e-03 0.00503
0.1 0.9480 1.26 0.00352 0.000778 1.99e-03 0.00504
0.2 0.9470 1.58 0.00352 0.000779 1.99e-03 0.00504
0.3 0.9470 2.00 0.00352 0.000779 1.99e-03 0.00504
0.4 0.9470 2.51 0.00352 0.000779 1.99e-03 0.00504
0.5 0.9410 3.16 0.00352 0.000786 1.97e-03 0.00506
0.6 0.9350 3.98 0.00341 0.000773 1.89e-03 0.00492
0.7 0.9350 5.01 0.00341 0.000773 1.89e-03 0.00492
0.8 0.9350 6.31 0.00326 0.000754 1.78e-03 0.00474
0.9 0.9270 7.94 0.00300 0.000720 1.59e-03 0.00441
1.0 0.9050 10.00 0.00300 0.000737 1.56e-03 0.00445
1.1 0.8840 12.60 0.00297 0.000732 1.53e-03 0.00440
1.2 0.8700 15.80 0.00297 0.000745 1.51e-03 0.00443
1.3 0.8480 20.00 0.00289 0.000741 1.44e-03 0.00435
1.4 0.8050 25.10 0.00284 0.000752 1.37e-03 0.00432
1.5 0.7530 31.60 0.00280 0.000768 1.30e-03 0.00431
1.6 0.7180 39.80 0.00238 0.000719 9.68e-04 0.00379
1.7 0.6560 50.10 0.00238 0.000762 8.84e-04 0.00387
1.8 0.6040 63.10 0.00233 0.000784 7.96e-04 0.00387
1.9 0.5470 79.40 0.00233 0.000833 6.99e-04 0.00397
2.0 0.4630 100.00 0.00233 0.000854 6.57e-04 0.00401
2.1 0.4140 126.00 0.00233 0.000918 5.33e-04 0.00413
2.2 0.3610 158.00 0.00233 0.001070 2.38e-04 0.00443
2.3 0.3250 200.00 0.00233 0.001210 -3.78e-05 0.00470
2.4 0.2830 251.00 0.00233 0.001160 5.90e-05 0.00461
2.5 0.2420 316.00 0.00233 0.001270 -1.65e-04 0.00483
2.6 0.1980 398.00 0.00233 0.001540 -6.96e-04 0.00536
2.7 0.1400 501.00 0.00233 0.002290 -2.16e-03 0.00683
2.8 0.1120 631.00 0.00233 0.002170 -1.92e-03 0.00659
2.9 0.0985 794.00 0.00233 0.002290 -2.15e-03 0.00681

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00361 0.000724 0.002110 0.00517
0.1 1.26 0.9480 0.00351 0.000778 0.001980 0.00503
0.2 1.58 0.9470 0.00351 0.000779 0.001980 0.00504
0.3 2.00 0.9470 0.00351 0.000779 0.001980 0.00504
0.4 2.51 0.9470 0.00351 0.000779 0.001980 0.00504
0.5 3.16 0.9410 0.00354 0.000786 0.002000 0.00508
0.6 3.98 0.9350 0.00341 0.000773 0.001890 0.00492
0.7 5.01 0.9350 0.00341 0.000773 0.001890 0.00492
0.8 6.31 0.9350 0.00326 0.000754 0.001780 0.00474
0.9 7.94 0.9270 0.00297 0.000720 0.001560 0.00438
1.0 10.00 0.9050 0.00304 0.000737 0.001590 0.00448
1.1 12.60 0.8840 0.00294 0.000732 0.001510 0.00438
1.2 15.80 0.8700 0.00299 0.000745 0.001530 0.00445
1.3 20.00 0.8480 0.00289 0.000741 0.001440 0.00435
1.4 25.10 0.8050 0.00284 0.000752 0.001370 0.00432
1.5 31.60 0.7530 0.00280 0.000768 0.001300 0.00431
1.6 39.80 0.7180 0.00237 0.000719 0.000960 0.00378
1.7 50.10 0.6560 0.00238 0.000762 0.000891 0.00388
1.8 63.10 0.6040 0.00233 0.000784 0.000792 0.00386
1.9 79.40 0.5470 0.00233 0.000833 0.000696 0.00396
2.0 100.00 0.4630 0.00210 0.000854 0.000422 0.00377
2.1 126.00 0.4140 0.00225 0.000918 0.000455 0.00405
2.2 158.00 0.3610 0.00257 0.001070 0.000471 0.00466
2.3 200.00 0.3250 0.00289 0.001210 0.000521 0.00526
2.4 251.00 0.2830 0.00238 0.001160 0.000111 0.00466
2.5 316.00 0.2420 0.00235 0.001270 -0.000148 0.00485
2.6 398.00 0.1980 0.00285 0.001540 -0.000174 0.00588
2.7 501.00 0.1400 0.00423 0.002290 -0.000267 0.00872
2.8 631.00 0.1120 0.00348 0.002170 -0.000771 0.00774
2.9 794.00 0.0985 0.00365 0.002290 -0.000831 0.00813

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.220 0.214 -0.19900 0.638
0.1 0.9480 1.26 0.240 0.220 -0.19000 0.671
0.2 0.9470 1.58 0.240 0.220 -0.19100 0.671
0.3 0.9470 2.00 0.240 0.220 -0.19100 0.671
0.4 0.9470 2.51 0.240 0.220 -0.19100 0.671
0.5 0.9410 3.16 0.240 0.221 -0.19300 0.674
0.6 0.9350 3.98 0.263 0.216 -0.16000 0.687
0.7 0.9350 5.01 0.263 0.216 -0.16000 0.687
0.8 0.9350 6.31 0.296 0.209 -0.11400 0.706
0.9 0.9270 7.94 0.351 0.197 -0.03520 0.737
1.0 0.9050 10.00 0.351 0.200 -0.04100 0.743
1.1 0.8840 12.60 0.359 0.198 -0.02920 0.748
1.2 0.8700 15.80 0.359 0.200 -0.03370 0.752
1.3 0.8480 20.00 0.375 0.198 -0.01330 0.763
1.4 0.8050 25.10 0.385 0.199 -0.00433 0.775
1.5 0.7530 31.60 0.394 0.201 0.00114 0.788
1.6 0.7180 39.80 0.486 0.182 0.12900 0.844
1.7 0.6560 50.10 0.486 0.190 0.11300 0.860
1.8 0.6040 63.10 0.496 0.194 0.11700 0.875
1.9 0.5470 79.40 0.496 0.203 0.09810 0.894
2.0 0.4630 100.00 0.496 0.207 0.09010 0.902
2.1 0.4140 126.00 0.496 0.219 0.06600 0.926
2.2 0.3610 158.00 0.496 0.249 0.00756 0.985
2.3 0.3250 200.00 0.496 0.278 -0.04810 1.040
2.4 0.2830 251.00 0.496 0.268 -0.02850 1.020
2.5 0.2420 316.00 0.496 0.291 -0.07410 1.070
2.6 0.1980 398.00 0.496 0.347 -0.18400 1.180
2.7 0.1400 501.00 0.496 0.504 -0.49300 1.480
2.8 0.1120 631.00 0.496 0.478 -0.44200 1.430
2.9 0.0985 794.00 0.496 0.503 -0.48900 1.480

RV144 (42 month)

  • Adjustment covariates: dem_sex, BRA_risk
  • Event time variable: HIVwk42fu
  • Event type variable: HIVwk42
  • Weight variable: sample_weight
  • Reference timepoint: 1014 days
  • All learners: GLM

IgG V1V2 B.CaseA-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00595 0.000929 0.004130 0.00777
0.1 0.995 1.26 0.00584 0.001020 0.003840 0.00785
0.2 0.995 1.58 0.00584 0.001020 0.003840 0.00785
0.3 0.995 2.00 0.00584 0.001020 0.003840 0.00785
0.4 0.994 2.51 0.00584 0.001020 0.003840 0.00785
0.5 0.994 3.16 0.00584 0.001020 0.003840 0.00785
0.6 0.994 3.98 0.00584 0.001020 0.003840 0.00785
0.7 0.994 5.01 0.00584 0.001020 0.003840 0.00785
0.8 0.992 6.31 0.00584 0.001020 0.003840 0.00785
0.9 0.992 7.94 0.00584 0.001020 0.003840 0.00785
1.0 0.989 10.00 0.00584 0.001030 0.003830 0.00786
1.1 0.987 12.60 0.00584 0.001030 0.003830 0.00786
1.2 0.981 15.80 0.00584 0.001030 0.003820 0.00787
1.3 0.972 20.00 0.00584 0.001040 0.003800 0.00789
1.4 0.970 25.10 0.00584 0.001030 0.003820 0.00785
1.5 0.965 31.60 0.00584 0.001030 0.003810 0.00787
1.6 0.956 39.80 0.00584 0.001040 0.003790 0.00788
1.7 0.951 50.10 0.00576 0.001030 0.003740 0.00779
1.8 0.935 63.10 0.00541 0.001010 0.003440 0.00738
1.9 0.933 79.40 0.00530 0.000992 0.003360 0.00725
2.0 0.920 100.00 0.00530 0.001010 0.003330 0.00728
2.1 0.905 126.00 0.00527 0.001010 0.003290 0.00724
2.2 0.878 158.00 0.00525 0.001020 0.003250 0.00725
2.3 0.825 200.00 0.00502 0.001020 0.003010 0.00702
2.4 0.793 251.00 0.00488 0.001000 0.002910 0.00684
2.5 0.730 316.00 0.00488 0.001070 0.002780 0.00698
2.6 0.668 398.00 0.00488 0.001090 0.002740 0.00702
2.7 0.612 501.00 0.00488 0.001130 0.002670 0.00709
2.8 0.518 631.00 0.00488 0.001230 0.002460 0.00730
2.9 0.481 794.00 0.00488 0.001370 0.002200 0.00756
3.0 0.409 1000.00 0.00488 0.001540 0.001850 0.00790
3.1 0.349 1260.00 0.00488 0.001580 0.001770 0.00798
3.2 0.278 1580.00 0.00488 0.001870 0.001210 0.00854
3.3 0.204 2000.00 0.00488 0.002220 0.000531 0.00923
3.4 0.164 2510.00 0.00468 0.002270 0.000232 0.00913
3.5 0.132 3160.00 0.00330 0.002060 -0.000725 0.00733

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00595 0.000929 0.003920 0.00797
0.1 1.26 0.995 0.00582 0.001020 0.003820 0.00782
0.2 1.58 0.995 0.00582 0.001020 0.003820 0.00782
0.3 2.00 0.995 0.00582 0.001020 0.003820 0.00782
0.4 2.51 0.994 0.00583 0.001020 0.003820 0.00783
0.5 3.16 0.994 0.00583 0.001020 0.003820 0.00783
0.6 3.98 0.994 0.00583 0.001020 0.003820 0.00783
0.7 5.01 0.994 0.00583 0.001020 0.003820 0.00783
0.8 6.31 0.992 0.00583 0.001020 0.003830 0.00784
0.9 7.94 0.992 0.00583 0.001020 0.003830 0.00784
1.0 10.00 0.989 0.00585 0.001030 0.003840 0.00787
1.1 12.60 0.987 0.00586 0.001030 0.003840 0.00788
1.2 15.80 0.981 0.00589 0.001030 0.003860 0.00791
1.3 20.00 0.972 0.00594 0.001040 0.003890 0.00798
1.4 25.10 0.970 0.00580 0.001030 0.003780 0.00782
1.5 31.60 0.965 0.00583 0.001030 0.003800 0.00785
1.6 39.80 0.956 0.00589 0.001040 0.003840 0.00793
1.7 50.10 0.951 0.00576 0.001030 0.003740 0.00779
1.8 63.10 0.935 0.00541 0.001010 0.003440 0.00738
1.9 79.40 0.933 0.00527 0.000992 0.003320 0.00721
2.0 100.00 0.920 0.00534 0.001010 0.003370 0.00732
2.1 126.00 0.905 0.00527 0.001010 0.003290 0.00724
2.2 158.00 0.878 0.00525 0.001020 0.003250 0.00725
2.3 200.00 0.825 0.00502 0.001020 0.003010 0.00702
2.4 251.00 0.793 0.00469 0.001000 0.002720 0.00665
2.5 316.00 0.730 0.00489 0.001070 0.002790 0.00699
2.6 398.00 0.668 0.00469 0.001090 0.002550 0.00684
2.7 501.00 0.612 0.00461 0.001130 0.002400 0.00682
2.8 631.00 0.518 0.00463 0.001230 0.002220 0.00705
2.9 794.00 0.481 0.00511 0.001370 0.002440 0.00779
3.0 1000.00 0.409 0.00515 0.001540 0.002130 0.00818
3.1 1260.00 0.349 0.00511 0.001580 0.002000 0.00821
3.2 1580.00 0.278 0.00529 0.001870 0.001630 0.00896
3.3 2000.00 0.204 0.00515 0.002220 0.000806 0.00950
3.4 2510.00 0.164 0.00468 0.002270 0.000232 0.00913
3.5 3160.00 0.132 0.00330 0.002060 -0.000725 0.00733

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.228 0.164 -0.09420 0.549
0.1 0.995 1.26 0.241 0.172 -0.09590 0.578
0.2 0.995 1.58 0.241 0.172 -0.09590 0.578
0.3 0.995 2.00 0.241 0.172 -0.09590 0.578
0.4 0.994 2.51 0.241 0.172 -0.09610 0.578
0.5 0.994 3.16 0.241 0.172 -0.09610 0.578
0.6 0.994 3.98 0.241 0.172 -0.09610 0.578
0.7 0.994 5.01 0.241 0.172 -0.09610 0.578
0.8 0.992 6.31 0.241 0.172 -0.09640 0.579
0.9 0.992 7.94 0.241 0.172 -0.09640 0.579
1.0 0.989 10.00 0.241 0.173 -0.09720 0.580
1.1 0.987 12.60 0.241 0.173 -0.09740 0.580
1.2 0.981 15.80 0.241 0.173 -0.09840 0.581
1.3 0.972 20.00 0.241 0.174 -0.09990 0.582
1.4 0.970 25.10 0.242 0.173 -0.09630 0.580
1.5 0.965 31.60 0.242 0.173 -0.09740 0.582
1.6 0.956 39.80 0.242 0.174 -0.09930 0.583
1.7 0.951 50.10 0.252 0.172 -0.08590 0.589
1.8 0.935 63.10 0.298 0.165 -0.02590 0.622
1.9 0.933 79.40 0.311 0.163 -0.00742 0.630
2.0 0.920 100.00 0.311 0.164 -0.01060 0.633
2.1 0.905 126.00 0.316 0.164 -0.00539 0.637
2.2 0.878 158.00 0.318 0.165 -0.00559 0.641
2.3 0.825 200.00 0.349 0.163 0.03000 0.667
2.4 0.793 251.00 0.367 0.159 0.05470 0.678
2.5 0.730 316.00 0.367 0.166 0.04040 0.693
2.6 0.668 398.00 0.367 0.169 0.03560 0.697
2.7 0.612 501.00 0.367 0.173 0.02800 0.705
2.8 0.518 631.00 0.367 0.184 0.00496 0.728
2.9 0.481 794.00 0.367 0.200 -0.02460 0.758
3.0 0.409 1000.00 0.367 0.220 -0.06520 0.798
3.1 0.349 1260.00 0.367 0.225 -0.07450 0.808
3.2 0.278 1580.00 0.367 0.259 -0.14200 0.875
3.3 0.204 2000.00 0.367 0.302 -0.22600 0.959
3.4 0.164 2510.00 0.392 0.308 -0.21100 0.995
3.5 0.132 3160.00 0.571 0.274 0.03390 1.110

IgG V1V2 AE.A244-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00597 0.000929 0.004140 0.00779
0.1 0.995 1.26 0.00597 0.001040 0.003930 0.00800
0.2 0.995 1.58 0.00597 0.001040 0.003930 0.00800
0.3 0.995 2.00 0.00597 0.001040 0.003930 0.00800
0.4 0.995 2.51 0.00597 0.001040 0.003930 0.00800
0.5 0.995 3.16 0.00597 0.001040 0.003930 0.00800
0.6 0.995 3.98 0.00597 0.001040 0.003930 0.00800
0.7 0.994 5.01 0.00597 0.001040 0.003930 0.00800
0.8 0.992 6.31 0.00597 0.001040 0.003930 0.00800
0.9 0.992 7.94 0.00584 0.001020 0.003830 0.00785
1.0 0.992 10.00 0.00584 0.001020 0.003830 0.00785
1.1 0.992 12.60 0.00584 0.001020 0.003830 0.00785
1.2 0.992 15.80 0.00584 0.001020 0.003830 0.00785
1.3 0.992 20.00 0.00584 0.001020 0.003830 0.00785
1.4 0.992 25.10 0.00584 0.001020 0.003830 0.00785
1.5 0.992 31.60 0.00584 0.001020 0.003830 0.00785
1.6 0.992 39.80 0.00584 0.001020 0.003830 0.00785
1.7 0.992 50.10 0.00584 0.001020 0.003830 0.00785
1.8 0.990 63.10 0.00584 0.001030 0.003830 0.00785
1.9 0.990 79.40 0.00584 0.001030 0.003830 0.00785
2.0 0.990 100.00 0.00584 0.001030 0.003830 0.00785
2.1 0.989 126.00 0.00584 0.001030 0.003820 0.00785
2.2 0.988 158.00 0.00572 0.001010 0.003730 0.00770
2.3 0.988 200.00 0.00572 0.001010 0.003730 0.00770
2.4 0.988 251.00 0.00572 0.001010 0.003730 0.00770
2.5 0.987 316.00 0.00572 0.001020 0.003730 0.00771
2.6 0.987 398.00 0.00572 0.001020 0.003730 0.00771
2.7 0.981 501.00 0.00572 0.001020 0.003720 0.00772
2.8 0.981 631.00 0.00560 0.001010 0.003630 0.00758
2.9 0.981 794.00 0.00560 0.001010 0.003630 0.00758
3.0 0.981 1000.00 0.00560 0.001010 0.003630 0.00758
3.1 0.979 1260.00 0.00547 0.000993 0.003520 0.00742
3.2 0.970 1580.00 0.00539 0.000990 0.003450 0.00733
3.3 0.965 2000.00 0.00526 0.000976 0.003350 0.00718
3.4 0.964 2510.00 0.00526 0.000978 0.003350 0.00718
3.5 0.950 3160.00 0.00517 0.000973 0.003260 0.00708
3.6 0.932 3980.00 0.00495 0.000958 0.003070 0.00683
3.7 0.904 5010.00 0.00481 0.000952 0.002950 0.00668
3.8 0.859 6310.00 0.00481 0.000974 0.002900 0.00672
3.9 0.804 7940.00 0.00481 0.001000 0.002850 0.00678
4.0 0.731 10000.00 0.00481 0.001060 0.002730 0.00690
4.1 0.623 12600.00 0.00481 0.001190 0.002480 0.00715
4.2 0.570 15800.00 0.00481 0.001230 0.002400 0.00723
4.3 0.472 20000.00 0.00481 0.001370 0.002120 0.00750
4.4 0.237 25100.00 0.00481 0.002230 0.000433 0.00919

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00595 0.000929 0.00392 0.00797
0.1 1.26 0.995 0.00596 0.001040 0.00393 0.00800
0.2 1.58 0.995 0.00596 0.001040 0.00393 0.00800
0.3 2.00 0.995 0.00596 0.001040 0.00393 0.00800
0.4 2.51 0.995 0.00596 0.001040 0.00393 0.00800
0.5 3.16 0.995 0.00596 0.001040 0.00393 0.00800
0.6 3.98 0.995 0.00596 0.001040 0.00393 0.00800
0.7 5.01 0.994 0.00597 0.001040 0.00394 0.00801
0.8 6.31 0.992 0.00598 0.001040 0.00394 0.00802
0.9 7.94 0.992 0.00583 0.001020 0.00383 0.00784
1.0 10.00 0.992 0.00583 0.001020 0.00383 0.00784
1.1 12.60 0.992 0.00583 0.001020 0.00383 0.00784
1.2 15.80 0.992 0.00583 0.001020 0.00383 0.00784
1.3 20.00 0.992 0.00583 0.001020 0.00383 0.00784
1.4 25.10 0.992 0.00583 0.001020 0.00383 0.00784
1.5 31.60 0.992 0.00583 0.001020 0.00383 0.00784
1.6 39.80 0.992 0.00583 0.001020 0.00383 0.00784
1.7 50.10 0.992 0.00583 0.001020 0.00383 0.00784
1.8 63.10 0.990 0.00584 0.001030 0.00383 0.00785
1.9 79.40 0.990 0.00584 0.001030 0.00383 0.00785
2.0 100.00 0.990 0.00584 0.001030 0.00383 0.00785
2.1 126.00 0.989 0.00585 0.001030 0.00384 0.00787
2.2 158.00 0.988 0.00570 0.001010 0.00372 0.00769
2.3 200.00 0.988 0.00570 0.001010 0.00372 0.00769
2.4 251.00 0.988 0.00570 0.001010 0.00372 0.00769
2.5 316.00 0.987 0.00572 0.001020 0.00373 0.00771
2.6 398.00 0.987 0.00572 0.001020 0.00373 0.00771
2.7 501.00 0.981 0.00575 0.001020 0.00374 0.00775
2.8 631.00 0.981 0.00560 0.001010 0.00363 0.00758
2.9 794.00 0.981 0.00560 0.001010 0.00363 0.00758
3.0 1000.00 0.981 0.00560 0.001010 0.00363 0.00758
3.1 1260.00 0.979 0.00547 0.000993 0.00352 0.00742
3.2 1580.00 0.970 0.00539 0.000990 0.00345 0.00733
3.3 2000.00 0.965 0.00526 0.000976 0.00334 0.00717
3.4 2510.00 0.964 0.00527 0.000978 0.00335 0.00718
3.5 3160.00 0.950 0.00517 0.000973 0.00326 0.00708
3.6 3980.00 0.932 0.00495 0.000958 0.00307 0.00683
3.7 5010.00 0.904 0.00477 0.000952 0.00291 0.00664
3.8 6310.00 0.859 0.00472 0.000974 0.00281 0.00663
3.9 7940.00 0.804 0.00468 0.001000 0.00272 0.00664
4.0 10000.00 0.731 0.00477 0.001060 0.00268 0.00685
4.1 12600.00 0.623 0.00496 0.001190 0.00262 0.00730
4.2 15800.00 0.570 0.00489 0.001230 0.00248 0.00731
4.3 20000.00 0.472 0.00495 0.001370 0.00226 0.00764
4.4 25100.00 0.237 0.00565 0.002230 0.00127 0.01000

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.225 0.164 -0.09680 0.548
0.1 0.995 1.26 0.225 0.175 -0.11700 0.568
0.2 0.995 1.58 0.225 0.175 -0.11700 0.568
0.3 0.995 2.00 0.225 0.175 -0.11700 0.568
0.4 0.995 2.51 0.225 0.175 -0.11700 0.568
0.5 0.995 3.16 0.225 0.175 -0.11700 0.568
0.6 0.995 3.98 0.225 0.175 -0.11700 0.568
0.7 0.994 5.01 0.225 0.175 -0.11800 0.568
0.8 0.992 6.31 0.225 0.175 -0.11800 0.569
0.9 0.992 7.94 0.242 0.172 -0.09550 0.579
1.0 0.992 10.00 0.242 0.172 -0.09550 0.579
1.1 0.992 12.60 0.242 0.172 -0.09550 0.579
1.2 0.992 15.80 0.242 0.172 -0.09550 0.579
1.3 0.992 20.00 0.242 0.172 -0.09550 0.579
1.4 0.992 25.10 0.242 0.172 -0.09550 0.579
1.5 0.992 31.60 0.242 0.172 -0.09550 0.579
1.6 0.992 39.80 0.242 0.172 -0.09550 0.579
1.7 0.992 50.10 0.242 0.172 -0.09550 0.579
1.8 0.990 63.10 0.242 0.172 -0.09580 0.580
1.9 0.990 79.40 0.242 0.172 -0.09580 0.580
2.0 0.990 100.00 0.242 0.172 -0.09580 0.580
2.1 0.989 126.00 0.242 0.173 -0.09620 0.580
2.2 0.988 158.00 0.258 0.170 -0.07460 0.590
2.3 0.988 200.00 0.258 0.170 -0.07460 0.590
2.4 0.988 251.00 0.258 0.170 -0.07460 0.590
2.5 0.987 316.00 0.258 0.170 -0.07510 0.591
2.6 0.987 398.00 0.258 0.170 -0.07510 0.591
2.7 0.981 501.00 0.258 0.170 -0.07620 0.592
2.8 0.981 631.00 0.272 0.168 -0.05600 0.601
2.9 0.981 794.00 0.272 0.168 -0.05600 0.601
3.0 0.981 1000.00 0.272 0.168 -0.05600 0.601
3.1 0.979 1260.00 0.290 0.165 -0.03310 0.613
3.2 0.970 1580.00 0.300 0.163 -0.02010 0.620
3.3 0.965 2000.00 0.317 0.161 0.00200 0.631
3.4 0.964 2510.00 0.317 0.161 0.00166 0.632
3.5 0.950 3160.00 0.328 0.159 0.01640 0.641
3.6 0.932 3980.00 0.357 0.155 0.05290 0.661
3.7 0.904 5010.00 0.375 0.153 0.07540 0.675
3.8 0.859 6310.00 0.375 0.155 0.07070 0.680
3.9 0.804 7940.00 0.375 0.158 0.06500 0.685
4.0 0.731 10000.00 0.375 0.165 0.05190 0.698
4.1 0.623 12600.00 0.375 0.179 0.02400 0.726
4.2 0.570 15800.00 0.375 0.184 0.01520 0.735
4.3 0.472 20000.00 0.375 0.200 -0.01610 0.766
4.4 0.237 25100.00 0.375 0.304 -0.22000 0.971

IgG V1V2 C.1086-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00595 0.000929 0.004130 0.00777
0.1 0.995 1.26 0.00584 0.001020 0.003840 0.00784
0.2 0.994 1.58 0.00584 0.001020 0.003830 0.00785
0.3 0.994 2.00 0.00584 0.001020 0.003830 0.00785
0.4 0.992 2.51 0.00584 0.001020 0.003830 0.00785
0.5 0.992 3.16 0.00584 0.001020 0.003830 0.00785
0.6 0.992 3.98 0.00584 0.001020 0.003830 0.00785
0.7 0.992 5.01 0.00584 0.001020 0.003830 0.00785
0.8 0.992 6.31 0.00584 0.001020 0.003830 0.00785
0.9 0.992 7.94 0.00584 0.001020 0.003830 0.00785
1.0 0.992 10.00 0.00584 0.001020 0.003830 0.00785
1.1 0.992 12.60 0.00584 0.001020 0.003830 0.00785
1.2 0.992 15.80 0.00584 0.001020 0.003830 0.00785
1.3 0.990 20.00 0.00584 0.001030 0.003830 0.00785
1.4 0.990 25.10 0.00584 0.001030 0.003830 0.00785
1.5 0.989 31.60 0.00584 0.001030 0.003820 0.00786
1.6 0.987 39.80 0.00584 0.001030 0.003820 0.00786
1.7 0.987 50.10 0.00584 0.001030 0.003820 0.00786
1.8 0.987 63.10 0.00584 0.001030 0.003820 0.00786
1.9 0.981 79.40 0.00575 0.001020 0.003740 0.00775
2.0 0.981 100.00 0.00575 0.001020 0.003740 0.00775
2.1 0.981 126.00 0.00575 0.001020 0.003740 0.00775
2.2 0.981 158.00 0.00560 0.001010 0.003630 0.00758
2.3 0.981 200.00 0.00560 0.001010 0.003630 0.00758
2.4 0.981 251.00 0.00560 0.001010 0.003630 0.00758
2.5 0.961 316.00 0.00558 0.001010 0.003590 0.00756
2.6 0.955 398.00 0.00545 0.001000 0.003490 0.00742
2.7 0.955 501.00 0.00530 0.000985 0.003370 0.00723
2.8 0.950 631.00 0.00517 0.000973 0.003260 0.00707
2.9 0.950 794.00 0.00494 0.000940 0.003090 0.00678
3.0 0.940 1000.00 0.00494 0.000948 0.003080 0.00679
3.1 0.909 1260.00 0.00494 0.000977 0.003020 0.00685
3.2 0.852 1580.00 0.00491 0.000992 0.002970 0.00686
3.3 0.794 2000.00 0.00491 0.001040 0.002870 0.00696
3.4 0.736 2510.00 0.00490 0.001070 0.002800 0.00701
3.5 0.634 3160.00 0.00489 0.001120 0.002690 0.00708
3.6 0.554 3980.00 0.00489 0.001210 0.002520 0.00725
3.7 0.466 5010.00 0.00489 0.001340 0.002250 0.00752
3.8 0.386 6310.00 0.00489 0.001600 0.001760 0.00802
3.9 0.281 7940.00 0.00489 0.001890 0.001180 0.00860
4.0 0.198 10000.00 0.00489 0.002100 0.000777 0.00900
4.1 0.158 12600.00 0.00489 0.002370 0.000243 0.00953
4.2 0.116 15800.00 0.00324 0.002010 -0.000699 0.00718

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00595 0.000929 0.003920 0.00797
0.1 1.26 0.995 0.00582 0.001020 0.003820 0.00782
0.2 1.58 0.994 0.00583 0.001020 0.003820 0.00783
0.3 2.00 0.994 0.00583 0.001020 0.003820 0.00783
0.4 2.51 0.992 0.00583 0.001020 0.003830 0.00784
0.5 3.16 0.992 0.00583 0.001020 0.003830 0.00784
0.6 3.98 0.992 0.00583 0.001020 0.003830 0.00784
0.7 5.01 0.992 0.00583 0.001020 0.003830 0.00784
0.8 6.31 0.992 0.00583 0.001020 0.003830 0.00784
0.9 7.94 0.992 0.00583 0.001020 0.003830 0.00784
1.0 10.00 0.992 0.00583 0.001020 0.003830 0.00784
1.1 12.60 0.992 0.00583 0.001020 0.003830 0.00784
1.2 15.80 0.992 0.00583 0.001020 0.003830 0.00784
1.3 20.00 0.990 0.00584 0.001030 0.003830 0.00785
1.4 25.10 0.990 0.00584 0.001030 0.003830 0.00785
1.5 31.60 0.989 0.00586 0.001030 0.003840 0.00787
1.6 39.80 0.987 0.00586 0.001030 0.003850 0.00788
1.7 50.10 0.987 0.00586 0.001030 0.003850 0.00788
1.8 63.10 0.987 0.00586 0.001030 0.003850 0.00788
1.9 79.40 0.981 0.00575 0.001020 0.003740 0.00775
2.0 100.00 0.981 0.00575 0.001020 0.003740 0.00775
2.1 126.00 0.981 0.00575 0.001020 0.003740 0.00775
2.2 158.00 0.981 0.00560 0.001010 0.003630 0.00758
2.3 200.00 0.981 0.00560 0.001010 0.003630 0.00758
2.4 251.00 0.981 0.00560 0.001010 0.003630 0.00758
2.5 316.00 0.961 0.00558 0.001010 0.003590 0.00756
2.6 398.00 0.955 0.00545 0.001000 0.003490 0.00742
2.7 501.00 0.955 0.00530 0.000985 0.003370 0.00723
2.8 631.00 0.950 0.00517 0.000973 0.003260 0.00707
2.9 794.00 0.950 0.00487 0.000940 0.003020 0.00671
3.0 1000.00 0.940 0.00491 0.000948 0.003050 0.00676
3.1 1260.00 0.909 0.00504 0.000977 0.003130 0.00695
3.2 1580.00 0.852 0.00489 0.000992 0.002940 0.00683
3.3 2000.00 0.794 0.00494 0.001040 0.002900 0.00699
3.4 2510.00 0.736 0.00490 0.001070 0.002800 0.00701
3.5 3160.00 0.634 0.00458 0.001120 0.002390 0.00677
3.6 3980.00 0.554 0.00467 0.001210 0.002300 0.00703
3.7 5010.00 0.466 0.00475 0.001340 0.002110 0.00738
3.8 6310.00 0.386 0.00530 0.001600 0.002170 0.00843
3.9 7940.00 0.281 0.00534 0.001890 0.001630 0.00905
4.0 10000.00 0.198 0.00492 0.002100 0.000811 0.00903
4.1 12600.00 0.158 0.00509 0.002370 0.000446 0.00974
4.2 15800.00 0.116 0.00324 0.002010 -0.000699 0.00718

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.228 0.164 -0.09420 0.549
0.1 0.995 1.26 0.242 0.172 -0.09530 0.579
0.2 0.994 1.58 0.242 0.172 -0.09560 0.579
0.3 0.994 2.00 0.242 0.172 -0.09560 0.579
0.4 0.992 2.51 0.242 0.172 -0.09580 0.579
0.5 0.992 3.16 0.242 0.172 -0.09580 0.579
0.6 0.992 3.98 0.242 0.172 -0.09580 0.579
0.7 0.992 5.01 0.242 0.172 -0.09580 0.579
0.8 0.992 6.31 0.242 0.172 -0.09580 0.579
0.9 0.992 7.94 0.242 0.172 -0.09580 0.579
1.0 0.992 10.00 0.242 0.172 -0.09580 0.579
1.1 0.992 12.60 0.242 0.172 -0.09580 0.579
1.2 0.992 15.80 0.242 0.172 -0.09580 0.579
1.3 0.990 20.00 0.242 0.172 -0.09620 0.580
1.4 0.990 25.10 0.242 0.172 -0.09620 0.580
1.5 0.989 31.60 0.242 0.173 -0.09670 0.580
1.6 0.987 39.80 0.242 0.173 -0.09700 0.580
1.7 0.987 50.10 0.242 0.173 -0.09700 0.580
1.8 0.987 63.10 0.242 0.173 -0.09700 0.580
1.9 0.981 79.40 0.254 0.171 -0.08070 0.589
2.0 0.981 100.00 0.254 0.171 -0.08070 0.589
2.1 0.981 126.00 0.254 0.171 -0.08070 0.589
2.2 0.981 158.00 0.272 0.168 -0.05600 0.601
2.3 0.981 200.00 0.272 0.168 -0.05600 0.601
2.4 0.981 251.00 0.272 0.168 -0.05600 0.601
2.5 0.961 316.00 0.276 0.168 -0.05330 0.605
2.6 0.955 398.00 0.292 0.165 -0.03230 0.616
2.7 0.955 501.00 0.311 0.162 -0.00594 0.629
2.8 0.950 631.00 0.329 0.159 0.01700 0.641
2.9 0.950 794.00 0.359 0.153 0.05900 0.659
3.0 0.940 1000.00 0.359 0.154 0.05730 0.661
3.1 0.909 1260.00 0.359 0.157 0.05140 0.667
3.2 0.852 1580.00 0.362 0.158 0.05150 0.672
3.3 0.794 2000.00 0.362 0.164 0.04090 0.683
3.4 0.736 2510.00 0.363 0.167 0.03600 0.691
3.5 0.634 3160.00 0.365 0.172 0.02870 0.702
3.6 0.554 3980.00 0.365 0.181 0.00969 0.721
3.7 0.466 5010.00 0.365 0.197 -0.02100 0.752
3.8 0.386 6310.00 0.365 0.227 -0.07870 0.809
3.9 0.281 7940.00 0.365 0.262 -0.14900 0.880
4.0 0.198 10000.00 0.365 0.287 -0.19800 0.928
4.1 0.158 12600.00 0.365 0.321 -0.26400 0.995
4.2 0.116 15800.00 0.579 0.268 0.05420 1.100

IgG V1V2 C.1086-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00597 0.000929 0.00415 0.00779
0.1 0.9950 1.26 0.00597 0.001040 0.00394 0.00800
0.2 0.9950 1.58 0.00597 0.001040 0.00394 0.00800
0.3 0.9950 2.00 0.00597 0.001040 0.00394 0.00800
0.4 0.9940 2.51 0.00597 0.001040 0.00393 0.00800
0.5 0.9920 3.16 0.00597 0.001040 0.00393 0.00800
0.6 0.9920 3.98 0.00597 0.001040 0.00393 0.00800
0.7 0.9920 5.01 0.00584 0.001020 0.00383 0.00785
0.8 0.9920 6.31 0.00584 0.001020 0.00383 0.00785
0.9 0.9920 7.94 0.00584 0.001020 0.00383 0.00785
1.0 0.9920 10.00 0.00584 0.001020 0.00383 0.00785
1.1 0.9900 12.60 0.00584 0.001030 0.00383 0.00785
1.2 0.9900 15.80 0.00584 0.001030 0.00383 0.00785
1.3 0.9900 20.00 0.00584 0.001030 0.00383 0.00785
1.4 0.9900 25.10 0.00584 0.001030 0.00383 0.00785
1.5 0.9900 31.60 0.00584 0.001030 0.00383 0.00785
1.6 0.9900 39.80 0.00584 0.001030 0.00383 0.00785
1.7 0.9900 50.10 0.00584 0.001030 0.00383 0.00785
1.8 0.9900 63.10 0.00584 0.001030 0.00383 0.00785
1.9 0.9890 79.40 0.00584 0.001030 0.00382 0.00786
2.0 0.9880 100.00 0.00573 0.001010 0.00374 0.00771
2.1 0.9870 126.00 0.00573 0.001020 0.00374 0.00772
2.2 0.9870 158.00 0.00573 0.001020 0.00374 0.00772
2.3 0.9870 200.00 0.00573 0.001020 0.00374 0.00772
2.4 0.9870 251.00 0.00573 0.001020 0.00374 0.00772
2.5 0.9810 316.00 0.00573 0.001020 0.00372 0.00773
2.6 0.9810 398.00 0.00573 0.001020 0.00372 0.00773
2.7 0.9810 501.00 0.00562 0.001010 0.00365 0.00759
2.8 0.9760 631.00 0.00562 0.001010 0.00364 0.00760
2.9 0.9670 794.00 0.00540 0.000990 0.00346 0.00735
3.0 0.9670 1000.00 0.00540 0.000990 0.00346 0.00735
3.1 0.9630 1260.00 0.00540 0.000994 0.00346 0.00735
3.2 0.9520 1580.00 0.00531 0.000988 0.00338 0.00725
3.3 0.9370 2000.00 0.00527 0.000951 0.00341 0.00714
3.4 0.9160 2510.00 0.00527 0.000961 0.00339 0.00716
3.5 0.8940 3160.00 0.00527 0.000984 0.00334 0.00720
3.6 0.8580 3980.00 0.00527 0.001010 0.00329 0.00725
3.7 0.7630 5010.00 0.00527 0.001110 0.00309 0.00746
3.8 0.6750 6310.00 0.00527 0.001170 0.00298 0.00756
3.9 0.5820 7940.00 0.00527 0.001360 0.00261 0.00793
4.0 0.4960 10000.00 0.00527 0.001540 0.00226 0.00829
4.1 0.4170 12600.00 0.00500 0.001430 0.00220 0.00780
4.2 0.3270 15800.00 0.00500 0.001710 0.00165 0.00835
4.3 0.2430 20000.00 0.00500 0.001950 0.00117 0.00883
4.4 0.0777 25100.00 0.00500 0.004890 -0.00459 0.01460

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00595 0.000929 0.00392 0.00797
0.1 1.26 0.9950 0.00596 0.001040 0.00393 0.00800
0.2 1.58 0.9950 0.00596 0.001040 0.00393 0.00800
0.3 2.00 0.9950 0.00596 0.001040 0.00393 0.00800
0.4 2.51 0.9940 0.00597 0.001040 0.00394 0.00801
0.5 3.16 0.9920 0.00598 0.001040 0.00394 0.00802
0.6 3.98 0.9920 0.00598 0.001040 0.00394 0.00802
0.7 5.01 0.9920 0.00583 0.001020 0.00383 0.00784
0.8 6.31 0.9920 0.00583 0.001020 0.00383 0.00784
0.9 7.94 0.9920 0.00583 0.001020 0.00383 0.00784
1.0 10.00 0.9920 0.00583 0.001020 0.00383 0.00784
1.1 12.60 0.9900 0.00584 0.001030 0.00383 0.00785
1.2 15.80 0.9900 0.00584 0.001030 0.00383 0.00785
1.3 20.00 0.9900 0.00584 0.001030 0.00383 0.00785
1.4 25.10 0.9900 0.00584 0.001030 0.00383 0.00785
1.5 31.60 0.9900 0.00584 0.001030 0.00383 0.00785
1.6 39.80 0.9900 0.00584 0.001030 0.00383 0.00785
1.7 50.10 0.9900 0.00584 0.001030 0.00383 0.00785
1.8 63.10 0.9900 0.00584 0.001030 0.00383 0.00785
1.9 79.40 0.9890 0.00586 0.001030 0.00384 0.00787
2.0 100.00 0.9880 0.00571 0.001010 0.00372 0.00770
2.1 126.00 0.9870 0.00572 0.001020 0.00373 0.00771
2.2 158.00 0.9870 0.00572 0.001020 0.00373 0.00771
2.3 200.00 0.9870 0.00572 0.001020 0.00373 0.00771
2.4 251.00 0.9870 0.00572 0.001020 0.00373 0.00771
2.5 316.00 0.9810 0.00575 0.001020 0.00374 0.00775
2.6 398.00 0.9810 0.00575 0.001020 0.00374 0.00775
2.7 501.00 0.9810 0.00560 0.001010 0.00363 0.00758
2.8 631.00 0.9760 0.00564 0.001010 0.00366 0.00762
2.9 794.00 0.9670 0.00540 0.000990 0.00346 0.00734
3.0 1000.00 0.9670 0.00540 0.000990 0.00346 0.00734
3.1 1260.00 0.9630 0.00542 0.000994 0.00347 0.00737
3.2 1580.00 0.9520 0.00531 0.000988 0.00338 0.00725
3.3 2000.00 0.9370 0.00492 0.000951 0.00306 0.00678
3.4 2510.00 0.9160 0.00489 0.000961 0.00301 0.00678
3.5 3160.00 0.8940 0.00500 0.000984 0.00307 0.00693
3.6 3980.00 0.8580 0.00504 0.001010 0.00306 0.00702
3.7 5010.00 0.7630 0.00534 0.001110 0.00316 0.00753
3.8 6310.00 0.6750 0.00530 0.001170 0.00301 0.00760
3.9 7940.00 0.5820 0.00585 0.001360 0.00319 0.00851
4.0 10000.00 0.4960 0.00615 0.001540 0.00313 0.00916
4.1 12600.00 0.4170 0.00471 0.001430 0.00191 0.00751
4.2 15800.00 0.3270 0.00532 0.001710 0.00197 0.00867
4.3 20000.00 0.2430 0.00528 0.001950 0.00146 0.00911
4.4 25100.00 0.0777 0.00646 0.004890 -0.00313 0.01610

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.225 0.164 -0.097100 0.547
0.1 0.9950 1.26 0.225 0.175 -0.118000 0.568
0.2 0.9950 1.58 0.225 0.175 -0.118000 0.568
0.3 0.9950 2.00 0.225 0.175 -0.118000 0.568
0.4 0.9940 2.51 0.225 0.175 -0.118000 0.568
0.5 0.9920 3.16 0.225 0.175 -0.118000 0.569
0.6 0.9920 3.98 0.225 0.175 -0.118000 0.569
0.7 0.9920 5.01 0.242 0.172 -0.096000 0.579
0.8 0.9920 6.31 0.242 0.172 -0.096000 0.579
0.9 0.9920 7.94 0.242 0.172 -0.096000 0.579
1.0 0.9920 10.00 0.242 0.172 -0.096000 0.579
1.1 0.9900 12.60 0.242 0.172 -0.096300 0.579
1.2 0.9900 15.80 0.242 0.172 -0.096300 0.579
1.3 0.9900 20.00 0.242 0.172 -0.096300 0.579
1.4 0.9900 25.10 0.242 0.172 -0.096300 0.579
1.5 0.9900 31.60 0.242 0.172 -0.096300 0.579
1.6 0.9900 39.80 0.242 0.172 -0.096300 0.579
1.7 0.9900 50.10 0.242 0.172 -0.096300 0.579
1.8 0.9900 63.10 0.242 0.172 -0.096300 0.579
1.9 0.9890 79.40 0.242 0.173 -0.096900 0.580
2.0 0.9880 100.00 0.257 0.170 -0.076100 0.589
2.1 0.9870 126.00 0.257 0.170 -0.076500 0.590
2.2 0.9870 158.00 0.257 0.170 -0.076500 0.590
2.3 0.9870 200.00 0.257 0.170 -0.076500 0.590
2.4 0.9870 251.00 0.257 0.170 -0.076500 0.590
2.5 0.9810 316.00 0.257 0.170 -0.077600 0.591
2.6 0.9810 398.00 0.257 0.170 -0.077600 0.591
2.7 0.9810 501.00 0.270 0.168 -0.058700 0.599
2.8 0.9760 631.00 0.270 0.168 -0.059600 0.600
2.9 0.9670 794.00 0.298 0.164 -0.022500 0.619
3.0 0.9670 1000.00 0.298 0.164 -0.022500 0.619
3.1 0.9630 1260.00 0.298 0.164 -0.023300 0.620
3.2 0.9520 1580.00 0.310 0.162 -0.008270 0.628
3.3 0.9370 2000.00 0.315 0.158 0.005630 0.625
3.4 0.9160 2510.00 0.315 0.159 0.003590 0.627
3.5 0.8940 3160.00 0.315 0.161 -0.000982 0.632
3.6 0.8580 3980.00 0.315 0.164 -0.006340 0.637
3.7 0.7630 5010.00 0.315 0.175 -0.027800 0.659
3.8 0.6750 6310.00 0.315 0.181 -0.039600 0.671
3.9 0.5820 7940.00 0.315 0.202 -0.080400 0.711
4.0 0.4960 10000.00 0.315 0.223 -0.121000 0.752
4.1 0.4170 12600.00 0.351 0.208 -0.056200 0.758
4.2 0.3270 15800.00 0.351 0.241 -0.121000 0.823
4.3 0.2430 20000.00 0.351 0.270 -0.179000 0.880
4.4 0.0777 25100.00 0.351 0.642 -0.908000 1.610

IgG3 V1V2 B.CaseA-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00595 0.000929 0.004130 0.00777
0.1 0.9800 1.26 0.00558 0.000993 0.003630 0.00753
0.2 0.9760 1.58 0.00558 0.000996 0.003630 0.00753
0.3 0.9760 2.00 0.00558 0.000996 0.003630 0.00753
0.4 0.9510 2.51 0.00558 0.001010 0.003600 0.00755
0.5 0.9510 3.16 0.00558 0.001010 0.003600 0.00755
0.6 0.9330 3.98 0.00558 0.001030 0.003560 0.00759
0.7 0.9210 5.01 0.00558 0.001040 0.003540 0.00762
0.8 0.9210 6.31 0.00558 0.001040 0.003540 0.00762
0.9 0.9120 7.94 0.00558 0.001040 0.003550 0.00761
1.0 0.8790 10.00 0.00558 0.001070 0.003470 0.00769
1.1 0.8220 12.60 0.00558 0.001090 0.003450 0.00771
1.2 0.7910 15.80 0.00558 0.001120 0.003390 0.00777
1.3 0.7510 20.00 0.00558 0.001160 0.003310 0.00784
1.4 0.7170 25.10 0.00558 0.001180 0.003270 0.00789
1.5 0.6690 31.60 0.00545 0.001190 0.003110 0.00778
1.6 0.6180 39.80 0.00545 0.001230 0.003040 0.00786
1.7 0.5140 50.10 0.00545 0.001410 0.002690 0.00821
1.8 0.4730 63.10 0.00545 0.001460 0.002580 0.00831
1.9 0.4040 79.40 0.00512 0.001440 0.002300 0.00793
2.0 0.3280 100.00 0.00512 0.001500 0.002170 0.00807
2.1 0.2790 126.00 0.00512 0.001780 0.001630 0.00861
2.2 0.2230 158.00 0.00512 0.002320 0.000566 0.00967
2.3 0.1990 200.00 0.00512 0.002340 0.000531 0.00971
2.4 0.1570 251.00 0.00512 0.002980 -0.000724 0.01100
2.5 0.1290 316.00 0.00512 0.003390 -0.001530 0.01180
2.6 0.0959 398.00 0.00512 0.002770 -0.000314 0.01060
2.7 0.0761 501.00 0.00512 0.003640 -0.002010 0.01220
2.8 0.0512 631.00 0.00512 0.006910 -0.008430 0.01870
2.9 0.0455 794.00 0.00512 0.009340 -0.013200 0.02340
3.0 0.0340 1000.00 0.00512 0.007420 -0.009430 0.01970
3.1 0.0239 1260.00 0.00512 0.007110 -0.008820 0.01910
3.2 0.0239 1580.00 0.00512 0.007110 -0.008820 0.01910
3.3 0.0239 2000.00 0.00512 0.007110 -0.008820 0.01910

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00595 0.000929 0.003920 0.00797
0.1 1.26 0.9800 0.00548 0.000993 0.003530 0.00743
0.2 1.58 0.9760 0.00550 0.000996 0.003550 0.00745
0.3 2.00 0.9760 0.00550 0.000996 0.003550 0.00745
0.4 2.51 0.9510 0.00549 0.001010 0.003510 0.00746
0.5 3.16 0.9510 0.00549 0.001010 0.003510 0.00746
0.6 3.98 0.9330 0.00559 0.001030 0.003580 0.00761
0.7 5.01 0.9210 0.00566 0.001040 0.003620 0.00770
0.8 6.31 0.9210 0.00566 0.001040 0.003620 0.00770
0.9 7.94 0.9120 0.00556 0.001040 0.003530 0.00759
1.0 10.00 0.8790 0.00575 0.001070 0.003640 0.00785
1.1 12.60 0.8220 0.00556 0.001090 0.003430 0.00769
1.2 15.80 0.7910 0.00560 0.001120 0.003420 0.00779
1.3 20.00 0.7510 0.00570 0.001160 0.003430 0.00796
1.4 25.10 0.7170 0.00562 0.001180 0.003300 0.00793
1.5 31.60 0.6690 0.00537 0.001190 0.003040 0.00771
1.6 39.80 0.6180 0.00522 0.001230 0.002810 0.00763
1.7 50.10 0.5140 0.00566 0.001410 0.002900 0.00842
1.8 63.10 0.4730 0.00557 0.001460 0.002700 0.00843
1.9 79.40 0.4040 0.00473 0.001440 0.001910 0.00754
2.0 100.00 0.3280 0.00434 0.001500 0.001390 0.00729
2.1 126.00 0.2790 0.00510 0.001780 0.001610 0.00858
2.2 158.00 0.2230 0.00650 0.002320 0.001950 0.01110
2.3 200.00 0.1990 0.00591 0.002340 0.001320 0.01050
2.4 251.00 0.1570 0.00677 0.002980 0.000927 0.01260
2.5 316.00 0.1290 0.00646 0.003390 -0.000196 0.01310
2.6 398.00 0.0959 0.00476 0.002770 -0.000669 0.01020
2.7 501.00 0.0761 0.00523 0.003640 -0.001890 0.01240
2.8 631.00 0.0512 0.00766 0.006910 -0.005890 0.02120
2.9 794.00 0.0455 0.01030 0.009340 -0.007990 0.02860
3.0 1000.00 0.0340 0.01030 0.007420 -0.004250 0.02480
3.1 1260.00 0.0239 0.01570 0.007110 0.001720 0.02960
3.2 1580.00 0.0239 0.01570 0.007110 0.001720 0.02960
3.3 2000.00 0.0239 0.01570 0.007110 0.001720 0.02960

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.228 0.164 -0.0942 0.549
0.1 0.9800 1.26 0.276 0.166 -0.0497 0.601
0.2 0.9760 1.58 0.276 0.166 -0.0503 0.601
0.3 0.9760 2.00 0.276 0.166 -0.0503 0.601
0.4 0.9510 2.51 0.276 0.167 -0.0526 0.604
0.5 0.9510 3.16 0.276 0.167 -0.0526 0.604
0.6 0.9330 3.98 0.276 0.170 -0.0568 0.608
0.7 0.9210 5.01 0.276 0.171 -0.0593 0.610
0.8 0.9210 6.31 0.276 0.171 -0.0593 0.610
0.9 0.9120 7.94 0.276 0.170 -0.0583 0.609
1.0 0.8790 10.00 0.276 0.174 -0.0661 0.617
1.1 0.8220 12.60 0.276 0.176 -0.0685 0.620
1.2 0.7910 15.80 0.276 0.179 -0.0747 0.626
1.3 0.7510 20.00 0.276 0.183 -0.0829 0.634
1.4 0.7170 25.10 0.276 0.185 -0.0880 0.639
1.5 0.6690 31.60 0.293 0.185 -0.0705 0.656
1.6 0.6180 39.80 0.293 0.190 -0.0789 0.664
1.7 0.5140 50.10 0.293 0.209 -0.1180 0.703
1.8 0.4730 63.10 0.293 0.215 -0.1300 0.715
1.9 0.4040 79.40 0.335 0.210 -0.0757 0.746
2.0 0.3280 100.00 0.335 0.218 -0.0912 0.762
2.1 0.2790 126.00 0.335 0.250 -0.1550 0.825
2.2 0.2230 158.00 0.335 0.317 -0.2850 0.956
2.3 0.1990 200.00 0.335 0.319 -0.2890 0.960
2.4 0.1570 251.00 0.335 0.399 -0.4460 1.120
2.5 0.1290 316.00 0.335 0.451 -0.5490 1.220
2.6 0.0959 398.00 0.335 0.372 -0.3950 1.070
2.7 0.0761 501.00 0.335 0.482 -0.6090 1.280
2.8 0.0512 631.00 0.335 0.903 -1.4300 2.110
2.9 0.0455 794.00 0.335 1.220 -2.0500 2.720
3.0 0.0340 1000.00 0.335 0.968 -1.5600 2.230
3.1 0.0239 1260.00 0.335 0.928 -1.4800 2.150
3.2 0.0239 1580.00 0.335 0.928 -1.4800 2.150
3.3 0.0239 2000.00 0.335 0.928 -1.4800 2.150

IgG3 V1V2 AE.A244-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00595 0.000929 0.004130 0.00777
0.1 0.9880 1.26 0.00585 0.001030 0.003840 0.00787
0.2 0.9880 1.58 0.00585 0.001030 0.003840 0.00787
0.3 0.9880 2.00 0.00585 0.001030 0.003840 0.00787
0.4 0.9880 2.51 0.00585 0.001030 0.003840 0.00787
0.5 0.9880 3.16 0.00585 0.001030 0.003840 0.00787
0.6 0.9880 3.98 0.00585 0.001030 0.003840 0.00787
0.7 0.9860 5.01 0.00585 0.001030 0.003840 0.00787
0.8 0.9860 6.31 0.00574 0.001010 0.003750 0.00773
0.9 0.9820 7.94 0.00574 0.001020 0.003750 0.00773
1.0 0.9820 10.00 0.00574 0.001020 0.003750 0.00773
1.1 0.9800 12.60 0.00574 0.001020 0.003750 0.00774
1.2 0.9780 15.80 0.00574 0.001020 0.003740 0.00774
1.3 0.9720 20.00 0.00574 0.001030 0.003730 0.00775
1.4 0.9700 25.10 0.00568 0.001010 0.003690 0.00766
1.5 0.9660 31.60 0.00568 0.001020 0.003680 0.00767
1.6 0.9660 39.80 0.00568 0.001020 0.003680 0.00767
1.7 0.9590 50.10 0.00568 0.001020 0.003670 0.00768
1.8 0.9500 63.10 0.00563 0.001020 0.003640 0.00763
1.9 0.9410 79.40 0.00563 0.001030 0.003620 0.00765
2.0 0.9300 100.00 0.00559 0.001030 0.003570 0.00760
2.1 0.9300 126.00 0.00546 0.001010 0.003480 0.00744
2.2 0.9170 158.00 0.00546 0.001020 0.003450 0.00747
2.3 0.8940 200.00 0.00535 0.001010 0.003370 0.00733
2.4 0.8530 251.00 0.00535 0.001040 0.003310 0.00739
2.5 0.8170 316.00 0.00535 0.001060 0.003270 0.00743
2.6 0.7530 398.00 0.00535 0.001110 0.003170 0.00753
2.7 0.7070 501.00 0.00520 0.001110 0.003020 0.00738
2.8 0.6480 631.00 0.00520 0.001150 0.002940 0.00746
2.9 0.5840 794.00 0.00520 0.001180 0.002880 0.00752
3.0 0.4820 1000.00 0.00520 0.001400 0.002450 0.00795
3.1 0.4010 1260.00 0.00520 0.001510 0.002230 0.00817
3.2 0.3360 1580.00 0.00520 0.001690 0.001890 0.00851
3.3 0.2710 2000.00 0.00520 0.002020 0.001240 0.00916
3.4 0.2050 2510.00 0.00520 0.002570 0.000160 0.01020
3.5 0.1730 3160.00 0.00520 0.002870 -0.000418 0.01080
3.6 0.1310 3980.00 0.00520 0.003200 -0.001060 0.01150
3.7 0.1110 5010.00 0.00520 0.003760 -0.002170 0.01260
3.8 0.0759 6310.00 0.00520 0.003860 -0.002370 0.01280
3.9 0.0645 7940.00 0.00520 0.005640 -0.005860 0.01630

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00595 0.000929 3.92e-03 0.00797
0.1 1.26 0.9880 0.00585 0.001030 3.84e-03 0.00787
0.2 1.58 0.9880 0.00585 0.001030 3.84e-03 0.00787
0.3 2.00 0.9880 0.00585 0.001030 3.84e-03 0.00787
0.4 2.51 0.9880 0.00585 0.001030 3.84e-03 0.00787
0.5 3.16 0.9880 0.00585 0.001030 3.84e-03 0.00787
0.6 3.98 0.9880 0.00585 0.001030 3.84e-03 0.00787
0.7 5.01 0.9860 0.00586 0.001030 3.84e-03 0.00788
0.8 6.31 0.9860 0.00571 0.001010 3.73e-03 0.00770
0.9 7.94 0.9820 0.00573 0.001020 3.74e-03 0.00772
1.0 10.00 0.9820 0.00573 0.001020 3.74e-03 0.00772
1.1 12.60 0.9800 0.00574 0.001020 3.75e-03 0.00774
1.2 15.80 0.9780 0.00575 0.001020 3.75e-03 0.00775
1.3 20.00 0.9720 0.00578 0.001030 3.77e-03 0.00780
1.4 25.10 0.9700 0.00565 0.001010 3.67e-03 0.00764
1.5 31.60 0.9660 0.00567 0.001020 3.68e-03 0.00767
1.6 39.80 0.9660 0.00567 0.001020 3.68e-03 0.00767
1.7 50.10 0.9590 0.00571 0.001020 3.70e-03 0.00772
1.8 63.10 0.9500 0.00560 0.001020 3.61e-03 0.00760
1.9 79.40 0.9410 0.00566 0.001030 3.65e-03 0.00768
2.0 100.00 0.9300 0.00559 0.001030 3.57e-03 0.00760
2.1 126.00 0.9300 0.00543 0.001010 3.45e-03 0.00741
2.2 158.00 0.9170 0.00550 0.001020 3.49e-03 0.00751
2.3 200.00 0.8940 0.00528 0.001010 3.30e-03 0.00726
2.4 251.00 0.8530 0.00534 0.001040 3.30e-03 0.00738
2.5 316.00 0.8170 0.00536 0.001060 3.28e-03 0.00744
2.6 398.00 0.7530 0.00542 0.001110 3.24e-03 0.00761
2.7 501.00 0.7070 0.00514 0.001110 2.96e-03 0.00732
2.8 631.00 0.6480 0.00494 0.001150 2.68e-03 0.00721
2.9 794.00 0.5840 0.00472 0.001180 2.41e-03 0.00704
3.0 1000.00 0.4820 0.00540 0.001400 2.65e-03 0.00816
3.1 1260.00 0.4010 0.00514 0.001510 2.18e-03 0.00811
3.2 1580.00 0.3360 0.00532 0.001690 2.01e-03 0.00864
3.3 2000.00 0.2710 0.00602 0.002020 2.06e-03 0.00998
3.4 2510.00 0.2050 0.00682 0.002570 1.78e-03 0.01190
3.5 3160.00 0.1730 0.00661 0.002870 9.92e-04 0.01220
3.6 3980.00 0.1310 0.00677 0.003200 5.07e-04 0.01300
3.7 5010.00 0.1110 0.00737 0.003760 9.00e-07 0.01470
3.8 6310.00 0.0759 0.00586 0.003860 -1.71e-03 0.01340
3.9 7940.00 0.0645 0.00763 0.005640 -3.43e-03 0.01870

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.228 0.164 -0.0942 0.549
0.1 0.9880 1.26 0.240 0.173 -0.0986 0.578
0.2 0.9880 1.58 0.240 0.173 -0.0986 0.578
0.3 0.9880 2.00 0.240 0.173 -0.0986 0.578
0.4 0.9880 2.51 0.240 0.173 -0.0986 0.578
0.5 0.9880 3.16 0.240 0.173 -0.0986 0.578
0.6 0.9880 3.98 0.240 0.173 -0.0986 0.578
0.7 0.9860 5.01 0.240 0.173 -0.0989 0.579
0.8 0.9860 6.31 0.254 0.170 -0.0789 0.588
0.9 0.9820 7.94 0.254 0.170 -0.0793 0.588
1.0 0.9820 10.00 0.254 0.170 -0.0793 0.588
1.1 0.9800 12.60 0.254 0.170 -0.0797 0.588
1.2 0.9780 15.80 0.254 0.171 -0.0800 0.589
1.3 0.9720 20.00 0.254 0.171 -0.0813 0.590
1.4 0.9700 25.10 0.263 0.169 -0.0688 0.594
1.5 0.9660 31.60 0.263 0.170 -0.0696 0.595
1.6 0.9660 39.80 0.263 0.170 -0.0696 0.595
1.7 0.9590 50.10 0.263 0.170 -0.0709 0.596
1.8 0.9500 63.10 0.268 0.169 -0.0627 0.600
1.9 0.9410 79.40 0.268 0.170 -0.0651 0.602
2.0 0.9300 100.00 0.274 0.170 -0.0582 0.607
2.1 0.9300 126.00 0.291 0.166 -0.0352 0.617
2.2 0.9170 158.00 0.291 0.168 -0.0381 0.620
2.3 0.8940 200.00 0.305 0.165 -0.0182 0.629
2.4 0.8530 251.00 0.305 0.168 -0.0241 0.635
2.5 0.8170 316.00 0.305 0.170 -0.0285 0.639
2.6 0.7530 398.00 0.305 0.176 -0.0396 0.650
2.7 0.7070 501.00 0.325 0.174 -0.0165 0.666
2.8 0.6480 631.00 0.325 0.179 -0.0256 0.675
2.9 0.5840 794.00 0.325 0.182 -0.0316 0.681
3.0 0.4820 1000.00 0.325 0.207 -0.0804 0.730
3.1 0.4010 1260.00 0.325 0.219 -0.1050 0.755
3.2 0.3360 1580.00 0.325 0.240 -0.1460 0.795
3.3 0.2710 2000.00 0.325 0.280 -0.2240 0.873
3.4 0.2050 2510.00 0.325 0.348 -0.3570 1.010
3.5 0.1730 3160.00 0.325 0.385 -0.4290 1.080
3.6 0.1310 3980.00 0.325 0.426 -0.5110 1.160
3.7 0.1110 5010.00 0.325 0.498 -0.6510 1.300
3.8 0.0759 6310.00 0.325 0.511 -0.6770 1.330
3.9 0.0645 7940.00 0.325 0.739 -1.1200 1.770

IgG3 V1V2 C.1086-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00595 0.000929 0.004130 0.00777
0.1 0.9840 1.26 0.00588 0.001030 0.003860 0.00790
0.2 0.9840 1.58 0.00588 0.001030 0.003860 0.00790
0.3 0.9840 2.00 0.00588 0.001030 0.003860 0.00790
0.4 0.9840 2.51 0.00588 0.001030 0.003860 0.00790
0.5 0.9790 3.16 0.00588 0.001030 0.003850 0.00790
0.6 0.9790 3.98 0.00575 0.001020 0.003750 0.00775
0.7 0.9740 5.01 0.00568 0.001010 0.003710 0.00766
0.8 0.9690 6.31 0.00568 0.001010 0.003700 0.00767
0.9 0.9610 7.94 0.00568 0.001020 0.003680 0.00769
1.0 0.9570 10.00 0.00568 0.001030 0.003670 0.00770
1.1 0.9500 12.60 0.00565 0.001020 0.003660 0.00765
1.2 0.9390 15.80 0.00565 0.001030 0.003630 0.00767
1.3 0.9390 20.00 0.00565 0.001030 0.003630 0.00767
1.4 0.9350 25.10 0.00562 0.001020 0.003620 0.00762
1.5 0.9240 31.60 0.00562 0.001030 0.003600 0.00765
1.6 0.9100 39.80 0.00562 0.001050 0.003570 0.00768
1.7 0.9010 50.10 0.00558 0.001040 0.003540 0.00762
1.8 0.8720 63.10 0.00540 0.001010 0.003420 0.00738
1.9 0.8430 79.40 0.00540 0.001010 0.003430 0.00738
2.0 0.7660 100.00 0.00540 0.001100 0.003250 0.00755
2.1 0.7090 126.00 0.00540 0.001140 0.003170 0.00764
2.2 0.6560 158.00 0.00540 0.001100 0.003240 0.00757
2.3 0.6130 200.00 0.00540 0.001210 0.003040 0.00777
2.4 0.5500 251.00 0.00540 0.001280 0.002900 0.00790
2.5 0.4620 316.00 0.00540 0.001420 0.002630 0.00818
2.6 0.3750 398.00 0.00540 0.001730 0.002010 0.00879
2.7 0.3280 501.00 0.00540 0.001990 0.001510 0.00929
2.8 0.2490 631.00 0.00540 0.002370 0.000750 0.01010
2.9 0.1910 794.00 0.00540 0.002860 -0.000205 0.01100
3.0 0.1730 1000.00 0.00540 0.003350 -0.001160 0.01200
3.1 0.1320 1260.00 0.00540 0.003270 -0.000998 0.01180
3.2 0.0894 1580.00 0.00540 0.003430 -0.001320 0.01210
3.3 0.0645 2000.00 0.00540 0.004280 -0.003000 0.01380

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00595 0.000929 0.003920 0.00797
0.1 1.26 0.9840 0.00587 0.001030 0.003850 0.00789
0.2 1.58 0.9840 0.00587 0.001030 0.003850 0.00789
0.3 2.00 0.9840 0.00587 0.001030 0.003850 0.00789
0.4 2.51 0.9840 0.00587 0.001030 0.003850 0.00789
0.5 3.16 0.9790 0.00590 0.001030 0.003870 0.00792
0.6 3.98 0.9790 0.00575 0.001020 0.003750 0.00775
0.7 5.01 0.9740 0.00563 0.001010 0.003650 0.00760
0.8 6.31 0.9690 0.00566 0.001010 0.003670 0.00764
0.9 7.94 0.9610 0.00571 0.001020 0.003700 0.00772
1.0 10.00 0.9570 0.00574 0.001030 0.003720 0.00775
1.1 12.60 0.9500 0.00561 0.001020 0.003620 0.00761
1.2 15.80 0.9390 0.00567 0.001030 0.003650 0.00769
1.3 20.00 0.9390 0.00567 0.001030 0.003650 0.00769
1.4 25.10 0.9350 0.00555 0.001020 0.003550 0.00755
1.5 31.60 0.9240 0.00562 0.001030 0.003590 0.00764
1.6 39.80 0.9100 0.00570 0.001050 0.003640 0.00775
1.7 50.10 0.9010 0.00558 0.001040 0.003540 0.00762
1.8 63.10 0.8720 0.00521 0.001010 0.003230 0.00719
1.9 79.40 0.8430 0.00503 0.001010 0.003060 0.00701
2.0 100.00 0.7660 0.00534 0.001100 0.003190 0.00749
2.1 126.00 0.7090 0.00536 0.001140 0.003130 0.00759
2.2 158.00 0.6560 0.00474 0.001100 0.002570 0.00690
2.3 200.00 0.6130 0.00515 0.001210 0.002790 0.00752
2.4 251.00 0.5500 0.00506 0.001280 0.002560 0.00756
2.5 316.00 0.4620 0.00529 0.001420 0.002520 0.00807
2.6 398.00 0.3750 0.00595 0.001730 0.002570 0.00934
2.7 501.00 0.3280 0.00637 0.001990 0.002480 0.01030
2.8 631.00 0.2490 0.00690 0.002370 0.002250 0.01160
2.9 794.00 0.1910 0.00748 0.002860 0.001880 0.01310
3.0 1000.00 0.1730 0.00808 0.003350 0.001520 0.01460
3.1 1260.00 0.1320 0.00653 0.003270 0.000133 0.01290
3.2 1580.00 0.0894 0.00615 0.003430 -0.000571 0.01290
3.3 2000.00 0.0645 0.00649 0.004280 -0.001910 0.01490

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.228 0.164 -0.0942 0.549
0.1 0.9840 1.26 0.237 0.173 -0.1030 0.577
0.2 0.9840 1.58 0.237 0.173 -0.1030 0.577
0.3 0.9840 2.00 0.237 0.173 -0.1030 0.577
0.4 0.9840 2.51 0.237 0.173 -0.1030 0.577
0.5 0.9790 3.16 0.237 0.174 -0.1040 0.577
0.6 0.9790 3.98 0.253 0.171 -0.0812 0.588
0.7 0.9740 5.01 0.262 0.169 -0.0687 0.593
0.8 0.9690 6.31 0.262 0.169 -0.0696 0.594
0.9 0.9610 7.94 0.262 0.170 -0.0718 0.596
1.0 0.9570 10.00 0.262 0.171 -0.0727 0.597
1.1 0.9500 12.60 0.266 0.169 -0.0662 0.598
1.2 0.9390 15.80 0.266 0.171 -0.0685 0.600
1.3 0.9390 20.00 0.266 0.171 -0.0685 0.600
1.4 0.9350 25.10 0.270 0.169 -0.0617 0.602
1.5 0.9240 31.60 0.270 0.171 -0.0644 0.604
1.6 0.9100 39.80 0.270 0.172 -0.0676 0.607
1.7 0.9010 50.10 0.275 0.171 -0.0593 0.610
1.8 0.8720 63.10 0.299 0.166 -0.0264 0.624
1.9 0.8430 79.40 0.299 0.165 -0.0258 0.623
2.0 0.7660 100.00 0.299 0.175 -0.0436 0.641
2.1 0.7090 126.00 0.299 0.179 -0.0527 0.650
2.2 0.6560 158.00 0.299 0.176 -0.0455 0.643
2.3 0.6130 200.00 0.299 0.187 -0.0672 0.664
2.4 0.5500 251.00 0.299 0.194 -0.0817 0.679
2.5 0.4620 316.00 0.299 0.210 -0.1130 0.710
2.6 0.3750 398.00 0.299 0.246 -0.1840 0.781
2.7 0.3280 501.00 0.299 0.277 -0.2440 0.841
2.8 0.2490 631.00 0.299 0.324 -0.3370 0.934
2.9 0.1910 794.00 0.299 0.385 -0.4560 1.050
3.0 0.1730 1000.00 0.299 0.446 -0.5760 1.170
3.1 0.1320 1260.00 0.299 0.436 -0.5560 1.150
3.2 0.0894 1580.00 0.299 0.456 -0.5960 1.190
3.3 0.0645 2000.00 0.299 0.566 -0.8100 1.410

IgG3 V1V2 C.1086-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00595 0.000929 4.13e-03 0.00777
0.1 0.9850 1.26 0.00582 0.001010 3.84e-03 0.00781
0.2 0.9850 1.58 0.00582 0.001010 3.84e-03 0.00781
0.3 0.9850 2.00 0.00582 0.001010 3.84e-03 0.00781
0.4 0.9790 2.51 0.00582 0.001020 3.83e-03 0.00782
0.5 0.9780 3.16 0.00582 0.001020 3.83e-03 0.00782
0.6 0.9780 3.98 0.00582 0.001020 3.83e-03 0.00782
0.7 0.9720 5.01 0.00582 0.001030 3.81e-03 0.00783
0.8 0.9640 6.31 0.00582 0.001030 3.80e-03 0.00785
0.9 0.9640 7.94 0.00582 0.001030 3.80e-03 0.00785
1.0 0.9580 10.00 0.00582 0.001040 3.79e-03 0.00786
1.1 0.9490 12.60 0.00582 0.001050 3.77e-03 0.00788
1.2 0.9450 15.80 0.00582 0.001040 3.79e-03 0.00786
1.3 0.9450 20.00 0.00582 0.001020 3.82e-03 0.00783
1.4 0.9380 25.10 0.00582 0.001030 3.81e-03 0.00784
1.5 0.9190 31.60 0.00582 0.001040 3.79e-03 0.00785
1.6 0.9050 39.80 0.00582 0.001040 3.79e-03 0.00785
1.7 0.8820 50.10 0.00582 0.001070 3.73e-03 0.00792
1.8 0.8640 63.10 0.00582 0.001050 3.76e-03 0.00788
1.9 0.8640 79.40 0.00582 0.001050 3.76e-03 0.00788
2.0 0.8310 100.00 0.00582 0.001080 3.72e-03 0.00793
2.1 0.7930 126.00 0.00582 0.001070 3.73e-03 0.00792
2.2 0.7390 158.00 0.00582 0.001110 3.66e-03 0.00799
2.3 0.6760 200.00 0.00582 0.001190 3.49e-03 0.00816
2.4 0.6350 251.00 0.00582 0.001260 3.36e-03 0.00829
2.5 0.5740 316.00 0.00582 0.001390 3.10e-03 0.00855
2.6 0.5150 398.00 0.00582 0.001410 3.06e-03 0.00859
2.7 0.4440 501.00 0.00582 0.001590 2.71e-03 0.00894
2.8 0.3620 631.00 0.00582 0.001890 2.12e-03 0.00953
2.9 0.2910 794.00 0.00582 0.002230 1.45e-03 0.01020
3.0 0.2470 1000.00 0.00582 0.002570 7.95e-04 0.01090
3.1 0.1980 1260.00 0.00582 0.003020 -8.86e-05 0.01170
3.2 0.1450 1580.00 0.00582 0.003330 -7.10e-04 0.01240
3.3 0.1130 2000.00 0.00582 0.003740 -1.50e-03 0.01310
3.4 0.0892 2510.00 0.00582 0.004910 -3.81e-03 0.01550
3.5 0.0656 3160.00 0.00582 0.007050 -8.00e-03 0.01960
3.6 0.0552 3980.00 0.00582 0.005750 -5.44e-03 0.01710
3.7 0.0398 5010.00 0.00582 0.008030 -9.91e-03 0.02160

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00595 0.000929 0.003920 0.00797
0.1 1.26 0.9850 0.00572 0.001010 0.003730 0.00770
0.2 1.58 0.9850 0.00572 0.001010 0.003730 0.00770
0.3 2.00 0.9850 0.00572 0.001010 0.003730 0.00770
0.4 2.51 0.9790 0.00574 0.001020 0.003750 0.00774
0.5 3.16 0.9780 0.00575 0.001020 0.003750 0.00774
0.6 3.98 0.9780 0.00575 0.001020 0.003750 0.00774
0.7 5.01 0.9720 0.00578 0.001030 0.003770 0.00779
0.8 6.31 0.9640 0.00582 0.001030 0.003800 0.00785
0.9 7.94 0.9640 0.00582 0.001030 0.003800 0.00785
1.0 10.00 0.9580 0.00586 0.001040 0.003820 0.00790
1.1 12.60 0.9490 0.00592 0.001050 0.003860 0.00797
1.2 15.80 0.9450 0.00578 0.001040 0.003750 0.00782
1.3 20.00 0.9450 0.00563 0.001020 0.003630 0.00763
1.4 25.10 0.9380 0.00567 0.001030 0.003650 0.00768
1.5 31.60 0.9190 0.00563 0.001040 0.003600 0.00766
1.6 39.80 0.9050 0.00555 0.001040 0.003520 0.00758
1.7 50.10 0.8820 0.00572 0.001070 0.003620 0.00781
1.8 63.10 0.8640 0.00548 0.001050 0.003420 0.00754
1.9 79.40 0.8640 0.00548 0.001050 0.003420 0.00754
2.0 100.00 0.8310 0.00551 0.001080 0.003400 0.00762
2.1 126.00 0.7930 0.00524 0.001070 0.003140 0.00733
2.2 158.00 0.7390 0.00522 0.001110 0.003050 0.00738
2.3 200.00 0.6760 0.00539 0.001190 0.003050 0.00773
2.4 251.00 0.6350 0.00568 0.001260 0.003220 0.00815
2.5 316.00 0.5740 0.00622 0.001390 0.003500 0.00894
2.6 398.00 0.5150 0.00583 0.001410 0.003060 0.00860
2.7 501.00 0.4440 0.00606 0.001590 0.002950 0.00918
2.8 631.00 0.3620 0.00672 0.001890 0.003010 0.01040
2.9 794.00 0.2910 0.00730 0.002230 0.002930 0.01170
3.0 1000.00 0.2470 0.00726 0.002570 0.002240 0.01230
3.1 1260.00 0.1980 0.00858 0.003020 0.002660 0.01450
3.2 1580.00 0.1450 0.00774 0.003330 0.001210 0.01430
3.3 2000.00 0.1130 0.00855 0.003740 0.001230 0.01590
3.4 2510.00 0.0892 0.01010 0.004910 0.000497 0.01980
3.5 3160.00 0.0656 0.01290 0.007050 -0.000889 0.02680
3.6 3980.00 0.0552 0.00861 0.005750 -0.002650 0.01990
3.7 5010.00 0.0398 0.01170 0.008030 -0.004020 0.02740

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.228 0.164 -0.0942 0.549
0.1 0.9850 1.26 0.244 0.171 -0.0911 0.579
0.2 0.9850 1.58 0.244 0.171 -0.0911 0.579
0.3 0.9850 2.00 0.244 0.171 -0.0911 0.579
0.4 0.9790 2.51 0.244 0.171 -0.0919 0.579
0.5 0.9780 3.16 0.244 0.171 -0.0922 0.580
0.6 0.9780 3.98 0.244 0.171 -0.0922 0.580
0.7 0.9720 5.01 0.244 0.172 -0.0935 0.581
0.8 0.9640 6.31 0.244 0.173 -0.0952 0.583
0.9 0.9640 7.94 0.244 0.173 -0.0952 0.583
1.0 0.9580 10.00 0.244 0.174 -0.0963 0.584
1.1 0.9490 12.60 0.244 0.175 -0.0984 0.586
1.2 0.9450 15.80 0.244 0.173 -0.0960 0.584
1.3 0.9450 20.00 0.244 0.172 -0.0929 0.580
1.4 0.9380 25.10 0.244 0.172 -0.0943 0.582
1.5 0.9190 31.60 0.244 0.173 -0.0957 0.583
1.6 0.9050 39.80 0.244 0.173 -0.0956 0.583
1.7 0.8820 50.10 0.244 0.177 -0.1020 0.590
1.8 0.8640 63.10 0.244 0.175 -0.0987 0.586
1.9 0.8640 79.40 0.244 0.175 -0.0987 0.586
2.0 0.8310 100.00 0.244 0.177 -0.1030 0.591
2.1 0.7930 126.00 0.244 0.177 -0.1020 0.590
2.2 0.7390 158.00 0.244 0.180 -0.1100 0.597
2.3 0.6760 200.00 0.244 0.189 -0.1280 0.615
2.4 0.6350 251.00 0.244 0.197 -0.1420 0.629
2.5 0.5740 316.00 0.244 0.211 -0.1690 0.657
2.6 0.5150 398.00 0.244 0.213 -0.1740 0.662
2.7 0.4440 501.00 0.244 0.233 -0.2140 0.701
2.8 0.3620 631.00 0.244 0.268 -0.2820 0.770
2.9 0.2910 794.00 0.244 0.309 -0.3630 0.850
3.0 0.2470 1000.00 0.244 0.351 -0.4430 0.931
3.1 0.1980 1260.00 0.244 0.407 -0.5530 1.040
3.2 0.1450 1580.00 0.244 0.446 -0.6310 1.120
3.3 0.1130 2000.00 0.244 0.497 -0.7310 1.220
3.4 0.0892 2510.00 0.244 0.647 -1.0200 1.510
3.5 0.0656 3160.00 0.244 0.922 -1.5600 2.050
3.6 0.0552 3980.00 0.244 0.754 -1.2300 1.720
3.7 0.0398 5010.00 0.244 1.050 -1.8100 2.300

IgG_V1V2_CaseA2_elisa

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
-0.903 1.0000 0.125 0.00595 0.000929 0.004130 0.00777
-0.803 0.9790 0.157 0.00590 0.001040 0.003870 0.00793
-0.703 0.9160 0.198 0.00569 0.001050 0.003640 0.00774
-0.603 0.7770 0.249 0.00558 0.001130 0.003380 0.00779
-0.503 0.6720 0.314 0.00454 0.001070 0.002450 0.00664
-0.403 0.4790 0.395 0.00454 0.001300 0.002000 0.00708
-0.303 0.3360 0.498 0.00374 0.001450 0.000906 0.00658
-0.203 0.2160 0.626 0.00275 0.001350 0.000109 0.00539
-0.103 0.0986 0.789 0.00275 0.001880 -0.000932 0.00643

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
-0.903 0.125 1.0000 0.00595 0.000929 0.003920 0.00797
-0.803 0.157 0.9790 0.00590 0.001040 0.003870 0.00793
-0.703 0.198 0.9160 0.00569 0.001050 0.003640 0.00774
-0.603 0.249 0.7770 0.00558 0.001130 0.003380 0.00779
-0.503 0.314 0.6720 0.00450 0.001070 0.002410 0.00660
-0.403 0.395 0.4790 0.00459 0.001300 0.002050 0.00713
-0.303 0.498 0.3360 0.00374 0.001450 0.000906 0.00658
-0.203 0.626 0.2160 0.00250 0.001350 -0.000133 0.00514
-0.103 0.789 0.0986 0.00299 0.001880 -0.000690 0.00667

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
-0.903 1.0000 0.125 0.228 0.164 -0.0942 0.549
-0.803 0.9790 0.157 0.234 0.174 -0.1080 0.575
-0.703 0.9160 0.198 0.261 0.173 -0.0773 0.600
-0.603 0.7770 0.249 0.275 0.180 -0.0772 0.627
-0.503 0.6720 0.314 0.410 0.163 0.0910 0.729
-0.403 0.4790 0.395 0.410 0.189 0.0406 0.780
-0.303 0.3360 0.498 0.514 0.201 0.1210 0.907
-0.203 0.2160 0.626 0.643 0.182 0.2860 1.000
-0.103 0.0986 0.789 0.643 0.249 0.1550 1.130

IgG_gp70.V1V2CaseA2

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00595 0.000929 0.004130 0.00777
0.1 0.9950 1.26 0.00585 0.001020 0.003850 0.00785
0.2 0.9950 1.58 0.00585 0.001020 0.003850 0.00785
0.3 0.9950 2.00 0.00585 0.001020 0.003850 0.00785
0.4 0.9930 2.51 0.00585 0.001020 0.003850 0.00786
0.5 0.9930 3.16 0.00585 0.001020 0.003850 0.00786
0.6 0.9840 3.98 0.00585 0.001030 0.003830 0.00787
0.7 0.9840 5.01 0.00585 0.001030 0.003830 0.00787
0.8 0.9840 6.31 0.00585 0.001030 0.003830 0.00787
0.9 0.9840 7.94 0.00585 0.001030 0.003830 0.00787
1.0 0.9770 10.00 0.00585 0.001040 0.003820 0.00788
1.1 0.9700 12.60 0.00580 0.001030 0.003780 0.00782
1.2 0.9640 15.80 0.00569 0.001020 0.003690 0.00769
1.3 0.9580 20.00 0.00557 0.001010 0.003590 0.00755
1.4 0.9450 25.10 0.00550 0.001010 0.003520 0.00747
1.5 0.9290 31.60 0.00549 0.001010 0.003500 0.00748
1.6 0.9200 39.80 0.00549 0.001020 0.003490 0.00749
1.7 0.9110 50.10 0.00549 0.001030 0.003460 0.00752
1.8 0.8930 63.10 0.00519 0.001010 0.003220 0.00716
1.9 0.8530 79.40 0.00513 0.001010 0.003140 0.00712
2.0 0.8040 100.00 0.00513 0.001060 0.003050 0.00720
2.1 0.7400 126.00 0.00481 0.001040 0.002770 0.00685
2.2 0.6750 158.00 0.00481 0.001110 0.002650 0.00698
2.3 0.6450 200.00 0.00481 0.001130 0.002590 0.00704
2.4 0.5840 251.00 0.00460 0.001130 0.002390 0.00681
2.5 0.5120 316.00 0.00460 0.001280 0.002090 0.00711
2.6 0.4520 398.00 0.00438 0.001280 0.001870 0.00689
2.7 0.3730 501.00 0.00396 0.001300 0.001400 0.00651
2.8 0.2950 631.00 0.00309 0.001270 0.000607 0.00557
2.9 0.2310 794.00 0.00293 0.001130 0.000711 0.00515
3.0 0.1630 1000.00 0.00293 0.001970 -0.000929 0.00679
3.1 0.1400 1260.00 0.00293 0.001580 -0.000160 0.00602
3.2 0.0888 1580.00 0.00293 0.002250 -0.001470 0.00733

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00595 0.000929 3.92e-03 0.00797
0.1 1.26 0.9950 0.00582 0.001020 3.82e-03 0.00782
0.2 1.58 0.9950 0.00582 0.001020 3.82e-03 0.00782
0.3 2.00 0.9950 0.00582 0.001020 3.82e-03 0.00782
0.4 2.51 0.9930 0.00583 0.001020 3.82e-03 0.00783
0.5 3.16 0.9930 0.00583 0.001020 3.82e-03 0.00783
0.6 3.98 0.9840 0.00587 0.001030 3.85e-03 0.00789
0.7 5.01 0.9840 0.00587 0.001030 3.85e-03 0.00789
0.8 6.31 0.9840 0.00587 0.001030 3.85e-03 0.00789
0.9 7.94 0.9840 0.00587 0.001030 3.85e-03 0.00789
1.0 10.00 0.9770 0.00591 0.001040 3.88e-03 0.00794
1.1 12.60 0.9700 0.00580 0.001030 3.78e-03 0.00782
1.2 15.80 0.9640 0.00569 0.001020 3.69e-03 0.00769
1.3 20.00 0.9580 0.00557 0.001010 3.59e-03 0.00755
1.4 25.10 0.9450 0.00550 0.001010 3.52e-03 0.00747
1.5 31.60 0.9290 0.00544 0.001010 3.46e-03 0.00743
1.6 39.80 0.9200 0.00548 0.001020 3.48e-03 0.00748
1.7 50.10 0.9110 0.00554 0.001030 3.52e-03 0.00757
1.8 63.10 0.8930 0.00519 0.001010 3.22e-03 0.00716
1.9 79.40 0.8530 0.00507 0.001010 3.08e-03 0.00706
2.0 100.00 0.8040 0.00519 0.001060 3.11e-03 0.00726
2.1 126.00 0.7400 0.00475 0.001040 2.71e-03 0.00679
2.2 158.00 0.6750 0.00484 0.001110 2.67e-03 0.00701
2.3 200.00 0.6450 0.00485 0.001130 2.63e-03 0.00707
2.4 251.00 0.5840 0.00440 0.001130 2.19e-03 0.00661
2.5 316.00 0.5120 0.00481 0.001280 2.30e-03 0.00732
2.6 398.00 0.4520 0.00438 0.001280 1.87e-03 0.00689
2.7 501.00 0.3730 0.00396 0.001300 1.40e-03 0.00651
2.8 631.00 0.2950 0.00309 0.001270 6.07e-04 0.00557
2.9 794.00 0.2310 0.00213 0.001130 -8.53e-05 0.00435
3.0 1000.00 0.1630 0.00343 0.001970 -4.32e-04 0.00729
3.1 1260.00 0.1400 0.00258 0.001580 -5.10e-04 0.00567
3.2 1580.00 0.0888 0.00358 0.002250 -8.24e-04 0.00798

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.228 0.164 -0.09420 0.549
0.1 0.9950 1.26 0.240 0.172 -0.09700 0.577
0.2 0.9950 1.58 0.240 0.172 -0.09700 0.577
0.3 0.9950 2.00 0.240 0.172 -0.09700 0.577
0.4 0.9930 2.51 0.240 0.172 -0.09730 0.578
0.5 0.9930 3.16 0.240 0.172 -0.09730 0.578
0.6 0.9840 3.98 0.240 0.173 -0.09890 0.579
0.7 0.9840 5.01 0.240 0.173 -0.09890 0.579
0.8 0.9840 6.31 0.240 0.173 -0.09890 0.579
0.9 0.9840 7.94 0.240 0.173 -0.09890 0.579
1.0 0.9770 10.00 0.240 0.174 -0.10000 0.581
1.1 0.9700 12.60 0.247 0.172 -0.09060 0.584
1.2 0.9640 15.80 0.261 0.170 -0.07150 0.594
1.3 0.9580 20.00 0.277 0.167 -0.05110 0.605
1.4 0.9450 25.10 0.286 0.167 -0.04030 0.613
1.5 0.9290 31.60 0.287 0.167 -0.04000 0.615
1.6 0.9200 39.80 0.287 0.168 -0.04150 0.616
1.7 0.9110 50.10 0.287 0.169 -0.04410 0.619
1.8 0.8930 63.10 0.326 0.163 0.00665 0.645
1.9 0.8530 79.40 0.334 0.163 0.01470 0.654
2.0 0.8040 100.00 0.334 0.168 0.00537 0.663
2.1 0.7400 126.00 0.375 0.162 0.05650 0.693
2.2 0.6750 158.00 0.375 0.170 0.04250 0.707
2.3 0.6450 200.00 0.375 0.173 0.03660 0.713
2.4 0.5840 251.00 0.403 0.170 0.06940 0.736
2.5 0.5120 316.00 0.403 0.187 0.03560 0.770
2.6 0.4520 398.00 0.431 0.185 0.06810 0.795
2.7 0.3730 501.00 0.486 0.185 0.12400 0.848
2.8 0.2950 631.00 0.599 0.174 0.25800 0.941
2.9 0.2310 794.00 0.620 0.157 0.31200 0.927
3.0 0.1630 1000.00 0.620 0.261 0.10700 1.130
3.1 0.1400 1260.00 0.620 0.212 0.20400 1.030
3.2 0.0888 1580.00 0.620 0.297 0.03790 1.200

IgG_A244D11K169

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00595 0.000929 0.00413 0.00777
0.1 0.9940 1.26 0.00585 0.001020 0.00384 0.00785
0.2 0.9940 1.58 0.00585 0.001020 0.00384 0.00785
0.3 0.9940 2.00 0.00585 0.001020 0.00384 0.00785
0.4 0.9940 2.51 0.00585 0.001020 0.00384 0.00785
0.5 0.9940 3.16 0.00585 0.001020 0.00384 0.00785
0.6 0.9940 3.98 0.00585 0.001020 0.00384 0.00785
0.7 0.9920 5.01 0.00585 0.001020 0.00384 0.00785
0.8 0.9920 6.31 0.00585 0.001020 0.00384 0.00785
0.9 0.9920 7.94 0.00585 0.001020 0.00384 0.00785
1.0 0.9920 10.00 0.00585 0.001020 0.00384 0.00785
1.1 0.9920 12.60 0.00585 0.001020 0.00384 0.00785
1.2 0.9920 15.80 0.00585 0.001020 0.00384 0.00785
1.3 0.9920 20.00 0.00585 0.001020 0.00384 0.00785
1.4 0.9900 25.10 0.00585 0.001030 0.00383 0.00786
1.5 0.9900 31.60 0.00585 0.001030 0.00383 0.00786
1.6 0.9890 39.80 0.00585 0.001030 0.00383 0.00786
1.7 0.9890 50.10 0.00585 0.001030 0.00383 0.00786
1.8 0.9880 63.10 0.00585 0.001010 0.00386 0.00783
1.9 0.9880 79.40 0.00585 0.001010 0.00386 0.00783
2.0 0.9870 100.00 0.00585 0.001020 0.00386 0.00784
2.1 0.9870 126.00 0.00585 0.001020 0.00386 0.00784
2.2 0.9850 158.00 0.00585 0.001020 0.00385 0.00784
2.3 0.9850 200.00 0.00585 0.001020 0.00385 0.00784
2.4 0.9850 251.00 0.00585 0.001020 0.00385 0.00784
2.5 0.9850 316.00 0.00585 0.001020 0.00385 0.00784
2.6 0.9850 398.00 0.00585 0.001020 0.00385 0.00784
2.7 0.9850 501.00 0.00585 0.001000 0.00388 0.00781
2.8 0.9690 631.00 0.00585 0.001020 0.00385 0.00784
2.9 0.9610 794.00 0.00585 0.001010 0.00387 0.00782
3.0 0.9520 1000.00 0.00585 0.001000 0.00388 0.00781
3.1 0.9150 1260.00 0.00585 0.001030 0.00383 0.00786
3.2 0.8590 1580.00 0.00585 0.001080 0.00374 0.00796
3.3 0.8030 2000.00 0.00585 0.001100 0.00369 0.00800
3.4 0.7020 2510.00 0.00585 0.001160 0.00357 0.00813
3.5 0.5770 3160.00 0.00585 0.001350 0.00321 0.00849
3.6 0.4180 3980.00 0.00585 0.001700 0.00252 0.00917
3.7 0.3710 5010.00 0.00585 0.001770 0.00237 0.00932
3.8 0.2660 6310.00 0.00585 0.002060 0.00180 0.00989
3.9 0.1340 7940.00 0.00585 0.004570 -0.00312 0.01480
4.0 0.0839 10000.00 0.00585 0.005760 -0.00545 0.01710
4.1 0.0476 12600.00 0.00585 0.010400 -0.01460 0.02630
4.2 0.0252 15800.00 0.00585 0.019300 -0.03190 0.04360

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00595 0.000929 0.00392 0.00797
0.1 1.26 0.9940 0.00583 0.001020 0.00382 0.00783
0.2 1.58 0.9940 0.00583 0.001020 0.00382 0.00783
0.3 2.00 0.9940 0.00583 0.001020 0.00382 0.00783
0.4 2.51 0.9940 0.00583 0.001020 0.00382 0.00783
0.5 3.16 0.9940 0.00583 0.001020 0.00382 0.00783
0.6 3.98 0.9940 0.00583 0.001020 0.00382 0.00783
0.7 5.01 0.9920 0.00583 0.001020 0.00383 0.00784
0.8 6.31 0.9920 0.00583 0.001020 0.00383 0.00784
0.9 7.94 0.9920 0.00583 0.001020 0.00383 0.00784
1.0 10.00 0.9920 0.00583 0.001020 0.00383 0.00784
1.1 12.60 0.9920 0.00583 0.001020 0.00383 0.00784
1.2 15.80 0.9920 0.00583 0.001020 0.00383 0.00784
1.3 20.00 0.9920 0.00583 0.001020 0.00383 0.00784
1.4 25.10 0.9900 0.00584 0.001030 0.00383 0.00785
1.5 31.60 0.9900 0.00584 0.001030 0.00383 0.00785
1.6 39.80 0.9890 0.00585 0.001030 0.00384 0.00787
1.7 50.10 0.9890 0.00585 0.001030 0.00384 0.00787
1.8 63.10 0.9880 0.00570 0.001010 0.00372 0.00769
1.9 79.40 0.9880 0.00570 0.001010 0.00372 0.00769
2.0 100.00 0.9870 0.00572 0.001020 0.00373 0.00771
2.1 126.00 0.9870 0.00572 0.001020 0.00373 0.00771
2.2 158.00 0.9850 0.00573 0.001020 0.00373 0.00772
2.3 200.00 0.9850 0.00573 0.001020 0.00373 0.00772
2.4 251.00 0.9850 0.00573 0.001020 0.00373 0.00772
2.5 316.00 0.9850 0.00573 0.001020 0.00373 0.00772
2.6 398.00 0.9850 0.00573 0.001020 0.00373 0.00772
2.7 501.00 0.9850 0.00559 0.001000 0.00362 0.00755
2.8 631.00 0.9690 0.00568 0.001020 0.00368 0.00767
2.9 794.00 0.9610 0.00556 0.001010 0.00358 0.00753
3.0 1000.00 0.9520 0.00545 0.001000 0.00349 0.00742
3.1 1260.00 0.9150 0.00552 0.001030 0.00350 0.00754
3.2 1580.00 0.8590 0.00568 0.001080 0.00357 0.00779
3.3 2000.00 0.8030 0.00554 0.001100 0.00339 0.00770
3.4 2510.00 0.7020 0.00545 0.001160 0.00317 0.00773
3.5 3160.00 0.5770 0.00568 0.001350 0.00304 0.00832
3.6 3980.00 0.4180 0.00655 0.001700 0.00322 0.00988
3.7 5010.00 0.3710 0.00645 0.001770 0.00298 0.00992
3.8 6310.00 0.2660 0.00627 0.002060 0.00223 0.01030
3.9 7940.00 0.1340 0.01230 0.004570 0.00331 0.02120
4.0 10000.00 0.0839 0.00970 0.005760 -0.00160 0.02100
4.1 12600.00 0.0476 0.01520 0.010400 -0.00526 0.03560
4.2 15800.00 0.0252 0.02460 0.019300 -0.01320 0.06230

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.228 0.164 -0.0942 0.549
0.1 0.9940 1.26 0.241 0.172 -0.0965 0.578
0.2 0.9940 1.58 0.241 0.172 -0.0965 0.578
0.3 0.9940 2.00 0.241 0.172 -0.0965 0.578
0.4 0.9940 2.51 0.241 0.172 -0.0965 0.578
0.5 0.9940 3.16 0.241 0.172 -0.0965 0.578
0.6 0.9940 3.98 0.241 0.172 -0.0965 0.578
0.7 0.9920 5.01 0.241 0.172 -0.0968 0.579
0.8 0.9920 6.31 0.241 0.172 -0.0968 0.579
0.9 0.9920 7.94 0.241 0.172 -0.0968 0.579
1.0 0.9920 10.00 0.241 0.172 -0.0968 0.579
1.1 0.9920 12.60 0.241 0.172 -0.0968 0.579
1.2 0.9920 15.80 0.241 0.172 -0.0968 0.579
1.3 0.9920 20.00 0.241 0.172 -0.0968 0.579
1.4 0.9900 25.10 0.241 0.172 -0.0972 0.579
1.5 0.9900 31.60 0.241 0.172 -0.0972 0.579
1.6 0.9890 39.80 0.241 0.173 -0.0975 0.579
1.7 0.9890 50.10 0.241 0.173 -0.0975 0.579
1.8 0.9880 63.10 0.241 0.171 -0.0946 0.576
1.9 0.9880 79.40 0.241 0.171 -0.0946 0.576
2.0 0.9870 100.00 0.241 0.171 -0.0950 0.577
2.1 0.9870 126.00 0.241 0.171 -0.0950 0.577
2.2 0.9850 158.00 0.241 0.172 -0.0954 0.577
2.3 0.9850 200.00 0.241 0.172 -0.0954 0.577
2.4 0.9850 251.00 0.241 0.172 -0.0954 0.577
2.5 0.9850 316.00 0.241 0.172 -0.0954 0.577
2.6 0.9850 398.00 0.241 0.172 -0.0954 0.577
2.7 0.9850 501.00 0.241 0.170 -0.0925 0.574
2.8 0.9690 631.00 0.241 0.172 -0.0955 0.577
2.9 0.9610 794.00 0.241 0.171 -0.0935 0.575
3.0 0.9520 1000.00 0.241 0.170 -0.0922 0.574
3.1 0.9150 1260.00 0.241 0.173 -0.0977 0.579
3.2 0.8590 1580.00 0.241 0.178 -0.1070 0.589
3.3 0.8030 2000.00 0.241 0.180 -0.1120 0.593
3.4 0.7020 2510.00 0.241 0.187 -0.1250 0.606
3.5 0.5770 3160.00 0.241 0.206 -0.1640 0.645
3.6 0.4180 3980.00 0.241 0.246 -0.2420 0.723
3.7 0.3710 5010.00 0.241 0.255 -0.2590 0.740
3.8 0.2660 6310.00 0.241 0.289 -0.3260 0.808
3.9 0.1340 7940.00 0.241 0.604 -0.9430 1.420
4.0 0.0839 10000.00 0.241 0.756 -1.2400 1.720
4.1 0.0476 12600.00 0.241 1.360 -2.4200 2.910
4.2 0.0252 15800.00 0.241 2.500 -4.6700 5.150

IgG_gp70ClAEV1V2

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00597 0.000929 0.00415 0.00779
0.1 0.997 1.26 0.00597 0.001030 0.00394 0.00800
0.2 0.997 1.58 0.00597 0.001030 0.00394 0.00800
0.3 0.997 2.00 0.00597 0.001030 0.00394 0.00800
0.4 0.995 2.51 0.00597 0.001040 0.00394 0.00800
0.5 0.994 3.16 0.00597 0.001040 0.00394 0.00800
0.6 0.992 3.98 0.00597 0.001040 0.00393 0.00801
0.7 0.992 5.01 0.00597 0.001040 0.00393 0.00801
0.8 0.992 6.31 0.00597 0.001040 0.00393 0.00801
0.9 0.992 7.94 0.00597 0.001040 0.00393 0.00801
1.0 0.992 10.00 0.00597 0.001040 0.00393 0.00801
1.1 0.992 12.60 0.00597 0.001040 0.00393 0.00801
1.2 0.992 15.80 0.00597 0.001040 0.00393 0.00801
1.3 0.992 20.00 0.00584 0.001020 0.00383 0.00785
1.4 0.992 25.10 0.00584 0.001020 0.00383 0.00785
1.5 0.992 31.60 0.00584 0.001020 0.00383 0.00785
1.6 0.992 39.80 0.00584 0.001020 0.00383 0.00785
1.7 0.990 50.10 0.00584 0.001030 0.00383 0.00785
1.8 0.990 63.10 0.00584 0.001030 0.00383 0.00785
1.9 0.990 79.40 0.00584 0.001030 0.00383 0.00785
2.0 0.990 100.00 0.00584 0.001030 0.00383 0.00785
2.1 0.990 126.00 0.00584 0.001030 0.00383 0.00785
2.2 0.990 158.00 0.00584 0.001030 0.00383 0.00785
2.3 0.990 200.00 0.00584 0.001030 0.00383 0.00785
2.4 0.989 251.00 0.00584 0.001030 0.00383 0.00786
2.5 0.987 316.00 0.00584 0.001030 0.00382 0.00786
2.6 0.987 398.00 0.00573 0.001020 0.00374 0.00772
2.7 0.987 501.00 0.00573 0.001020 0.00374 0.00772
2.8 0.987 631.00 0.00573 0.001020 0.00374 0.00772
2.9 0.981 794.00 0.00573 0.001020 0.00373 0.00773
3.0 0.981 1000.00 0.00573 0.001020 0.00373 0.00773
3.1 0.981 1260.00 0.00562 0.001010 0.00365 0.00759
3.2 0.976 1580.00 0.00562 0.001010 0.00364 0.00760
3.3 0.976 2000.00 0.00549 0.000996 0.00354 0.00744
3.4 0.967 2510.00 0.00540 0.000990 0.00346 0.00735
3.5 0.967 3160.00 0.00540 0.000990 0.00346 0.00735
3.6 0.963 3980.00 0.00540 0.000994 0.00346 0.00735
3.7 0.963 5010.00 0.00515 0.000963 0.00326 0.00704
3.8 0.951 6310.00 0.00515 0.000973 0.00324 0.00706
3.9 0.927 7940.00 0.00512 0.000969 0.00322 0.00702
4.0 0.922 10000.00 0.00512 0.000956 0.00325 0.00699
4.1 0.872 12600.00 0.00512 0.000998 0.00317 0.00708
4.2 0.807 15800.00 0.00512 0.001070 0.00303 0.00721
4.3 0.722 20000.00 0.00512 0.001150 0.00287 0.00738
4.4 0.408 25100.00 0.00512 0.001570 0.00204 0.00820

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00595 0.000929 0.00392 0.00797
0.1 1.26 0.997 0.00596 0.001030 0.00393 0.00799
0.2 1.58 0.997 0.00596 0.001030 0.00393 0.00799
0.3 2.00 0.997 0.00596 0.001030 0.00393 0.00799
0.4 2.51 0.995 0.00596 0.001040 0.00393 0.00800
0.5 3.16 0.994 0.00597 0.001040 0.00394 0.00801
0.6 3.98 0.992 0.00598 0.001040 0.00394 0.00802
0.7 5.01 0.992 0.00598 0.001040 0.00394 0.00802
0.8 6.31 0.992 0.00598 0.001040 0.00394 0.00802
0.9 7.94 0.992 0.00598 0.001040 0.00394 0.00802
1.0 10.00 0.992 0.00598 0.001040 0.00394 0.00802
1.1 12.60 0.992 0.00598 0.001040 0.00394 0.00802
1.2 15.80 0.992 0.00598 0.001040 0.00394 0.00802
1.3 20.00 0.992 0.00583 0.001020 0.00383 0.00784
1.4 25.10 0.992 0.00583 0.001020 0.00383 0.00784
1.5 31.60 0.992 0.00583 0.001020 0.00383 0.00784
1.6 39.80 0.992 0.00583 0.001020 0.00383 0.00784
1.7 50.10 0.990 0.00584 0.001030 0.00383 0.00785
1.8 63.10 0.990 0.00584 0.001030 0.00383 0.00785
1.9 79.40 0.990 0.00584 0.001030 0.00383 0.00785
2.0 100.00 0.990 0.00584 0.001030 0.00383 0.00785
2.1 126.00 0.990 0.00584 0.001030 0.00383 0.00785
2.2 158.00 0.990 0.00584 0.001030 0.00383 0.00785
2.3 200.00 0.990 0.00584 0.001030 0.00383 0.00785
2.4 251.00 0.989 0.00586 0.001030 0.00384 0.00787
2.5 316.00 0.987 0.00586 0.001030 0.00385 0.00788
2.6 398.00 0.987 0.00572 0.001020 0.00373 0.00771
2.7 501.00 0.987 0.00572 0.001020 0.00373 0.00771
2.8 631.00 0.987 0.00572 0.001020 0.00373 0.00771
2.9 794.00 0.981 0.00575 0.001020 0.00374 0.00775
3.0 1000.00 0.981 0.00575 0.001020 0.00374 0.00775
3.1 1260.00 0.981 0.00560 0.001010 0.00363 0.00758
3.2 1580.00 0.976 0.00564 0.001010 0.00366 0.00762
3.3 2000.00 0.976 0.00549 0.000996 0.00354 0.00744
3.4 2510.00 0.967 0.00540 0.000990 0.00346 0.00734
3.5 3160.00 0.967 0.00540 0.000990 0.00346 0.00734
3.6 3980.00 0.963 0.00542 0.000994 0.00347 0.00737
3.7 5010.00 0.963 0.00512 0.000963 0.00324 0.00701
3.8 6310.00 0.951 0.00518 0.000973 0.00327 0.00708
3.9 7940.00 0.927 0.00501 0.000969 0.00311 0.00691
4.0 10000.00 0.922 0.00487 0.000956 0.00300 0.00674
4.1 12600.00 0.872 0.00499 0.000998 0.00303 0.00694
4.2 15800.00 0.807 0.00522 0.001070 0.00313 0.00730
4.3 20000.00 0.722 0.00541 0.001150 0.00316 0.00767
4.4 25100.00 0.408 0.00534 0.001570 0.00226 0.00842

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.225 0.164 -0.09750 0.547
0.1 0.997 1.26 0.225 0.175 -0.11800 0.567
0.2 0.997 1.58 0.225 0.175 -0.11800 0.567
0.3 0.997 2.00 0.225 0.175 -0.11800 0.567
0.4 0.995 2.51 0.225 0.175 -0.11800 0.568
0.5 0.994 3.16 0.225 0.175 -0.11800 0.568
0.6 0.992 3.98 0.225 0.175 -0.11900 0.568
0.7 0.992 5.01 0.225 0.175 -0.11900 0.568
0.8 0.992 6.31 0.225 0.175 -0.11900 0.568
0.9 0.992 7.94 0.225 0.175 -0.11900 0.568
1.0 0.992 10.00 0.225 0.175 -0.11900 0.568
1.1 0.992 12.60 0.225 0.175 -0.11900 0.568
1.2 0.992 15.80 0.225 0.175 -0.11900 0.568
1.3 0.992 20.00 0.241 0.172 -0.09620 0.579
1.4 0.992 25.10 0.241 0.172 -0.09620 0.579
1.5 0.992 31.60 0.241 0.172 -0.09620 0.579
1.6 0.992 39.80 0.241 0.172 -0.09620 0.579
1.7 0.990 50.10 0.241 0.172 -0.09660 0.579
1.8 0.990 63.10 0.241 0.172 -0.09660 0.579
1.9 0.990 79.40 0.241 0.172 -0.09660 0.579
2.0 0.990 100.00 0.241 0.172 -0.09660 0.579
2.1 0.990 126.00 0.241 0.172 -0.09660 0.579
2.2 0.990 158.00 0.241 0.172 -0.09660 0.579
2.3 0.990 200.00 0.241 0.172 -0.09660 0.579
2.4 0.989 251.00 0.241 0.173 -0.09710 0.580
2.5 0.987 316.00 0.241 0.173 -0.09740 0.580
2.6 0.987 398.00 0.256 0.170 -0.07710 0.589
2.7 0.987 501.00 0.256 0.170 -0.07710 0.589
2.8 0.987 631.00 0.256 0.170 -0.07710 0.589
2.9 0.981 794.00 0.256 0.171 -0.07820 0.590
3.0 0.981 1000.00 0.256 0.171 -0.07820 0.590
3.1 0.981 1260.00 0.270 0.168 -0.05870 0.599
3.2 0.976 1580.00 0.270 0.168 -0.05960 0.600
3.3 0.976 2000.00 0.287 0.165 -0.03710 0.611
3.4 0.967 2510.00 0.298 0.164 -0.02250 0.619
3.5 0.967 3160.00 0.298 0.164 -0.02250 0.619
3.6 0.963 3980.00 0.298 0.164 -0.02330 0.620
3.7 0.963 5010.00 0.331 0.158 0.02180 0.641
3.8 0.951 6310.00 0.331 0.159 0.01970 0.643
3.9 0.927 7940.00 0.335 0.158 0.02490 0.645
4.0 0.922 10000.00 0.335 0.157 0.02770 0.642
4.1 0.872 12600.00 0.335 0.161 0.01920 0.651
4.2 0.807 15800.00 0.335 0.168 0.00509 0.665
4.3 0.722 20000.00 0.335 0.177 -0.01280 0.683
4.4 0.408 25100.00 0.335 0.225 -0.10700 0.777

IgG_gp70V1V2A

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00595 0.000929 0.004130 0.00777
0.1 0.9920 1.26 0.00590 0.001020 0.003890 0.00791
0.2 0.9920 1.58 0.00590 0.001020 0.003890 0.00791
0.3 0.9920 2.00 0.00590 0.001020 0.003890 0.00791
0.4 0.9900 2.51 0.00590 0.001030 0.003890 0.00791
0.5 0.9880 3.16 0.00590 0.001030 0.003890 0.00792
0.6 0.9880 3.98 0.00590 0.001030 0.003890 0.00792
0.7 0.9870 5.01 0.00590 0.001030 0.003880 0.00792
0.8 0.9850 6.31 0.00590 0.001030 0.003880 0.00792
0.9 0.9810 7.94 0.00590 0.001030 0.003880 0.00793
1.0 0.9810 10.00 0.00590 0.001030 0.003880 0.00793
1.1 0.9810 12.60 0.00590 0.001030 0.003880 0.00793
1.2 0.9660 15.80 0.00590 0.001050 0.003840 0.00796
1.3 0.9660 20.00 0.00590 0.001050 0.003840 0.00796
1.4 0.9660 25.10 0.00590 0.001050 0.003840 0.00796
1.5 0.9660 31.60 0.00590 0.001050 0.003840 0.00796
1.6 0.9500 39.80 0.00590 0.001050 0.003840 0.00796
1.7 0.9440 50.10 0.00590 0.001060 0.003820 0.00798
1.8 0.9390 63.10 0.00568 0.001030 0.003660 0.00771
1.9 0.9290 79.40 0.00560 0.001030 0.003580 0.00762
2.0 0.8990 100.00 0.00559 0.001040 0.003540 0.00763
2.1 0.8850 126.00 0.00521 0.001010 0.003230 0.00719
2.2 0.8550 158.00 0.00491 0.000996 0.002950 0.00686
2.3 0.8420 200.00 0.00462 0.000968 0.002720 0.00651
2.4 0.8180 251.00 0.00423 0.000935 0.002400 0.00606
2.5 0.7640 316.00 0.00395 0.000928 0.002130 0.00576
2.6 0.7150 398.00 0.00384 0.000948 0.001980 0.00570
2.7 0.6380 501.00 0.00377 0.000965 0.001880 0.00566
2.8 0.5210 631.00 0.00377 0.001100 0.001620 0.00592
2.9 0.4700 794.00 0.00377 0.001200 0.001430 0.00612
3.0 0.4320 1000.00 0.00377 0.001220 0.001380 0.00617
3.1 0.3450 1260.00 0.00377 0.001330 0.001170 0.00637
3.2 0.2870 1580.00 0.00377 0.001490 0.000858 0.00669
3.3 0.2200 2000.00 0.00377 0.001740 0.000354 0.00719
3.4 0.1630 2510.00 0.00377 0.002690 -0.001510 0.00905
3.5 0.1270 3160.00 0.00377 0.004290 -0.004640 0.01220
3.6 0.0993 3980.00 0.00377 0.004950 -0.005920 0.01350
3.7 0.0799 5010.00 0.00377 0.004820 -0.005670 0.01320

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00595 0.000929 0.003920 0.00797
0.1 1.26 0.9920 0.00584 0.001020 0.003830 0.00784
0.2 1.58 0.9920 0.00584 0.001020 0.003830 0.00784
0.3 2.00 0.9920 0.00584 0.001020 0.003830 0.00784
0.4 2.51 0.9900 0.00585 0.001030 0.003840 0.00786
0.5 3.16 0.9880 0.00586 0.001030 0.003840 0.00787
0.6 3.98 0.9880 0.00586 0.001030 0.003840 0.00787
0.7 5.01 0.9870 0.00586 0.001030 0.003850 0.00788
0.8 6.31 0.9850 0.00587 0.001030 0.003850 0.00790
0.9 7.94 0.9810 0.00590 0.001030 0.003870 0.00792
1.0 10.00 0.9810 0.00590 0.001030 0.003870 0.00792
1.1 12.60 0.9810 0.00590 0.001030 0.003870 0.00792
1.2 15.80 0.9660 0.00599 0.001050 0.003930 0.00805
1.3 20.00 0.9660 0.00599 0.001050 0.003930 0.00805
1.4 25.10 0.9660 0.00599 0.001050 0.003930 0.00805
1.5 31.60 0.9660 0.00599 0.001050 0.003930 0.00805
1.6 39.80 0.9500 0.00592 0.001050 0.003860 0.00798
1.7 50.10 0.9440 0.00597 0.001060 0.003890 0.00804
1.8 63.10 0.9390 0.00568 0.001030 0.003660 0.00771
1.9 79.40 0.9290 0.00560 0.001030 0.003580 0.00762
2.0 100.00 0.8990 0.00559 0.001040 0.003540 0.00763
2.1 126.00 0.8850 0.00521 0.001010 0.003230 0.00719
2.2 158.00 0.8550 0.00491 0.000996 0.002950 0.00686
2.3 200.00 0.8420 0.00462 0.000968 0.002720 0.00651
2.4 251.00 0.8180 0.00423 0.000935 0.002400 0.00606
2.5 316.00 0.7640 0.00395 0.000928 0.002130 0.00576
2.6 398.00 0.7150 0.00384 0.000948 0.001980 0.00570
2.7 501.00 0.6380 0.00359 0.000965 0.001690 0.00548
2.8 631.00 0.5210 0.00375 0.001100 0.001600 0.00590
2.9 794.00 0.4700 0.00394 0.001200 0.001590 0.00628
3.0 1000.00 0.4320 0.00383 0.001220 0.001440 0.00623
3.1 1260.00 0.3450 0.00360 0.001330 0.000997 0.00620
3.2 1580.00 0.2870 0.00381 0.001490 0.000896 0.00673
3.3 2000.00 0.2200 0.00394 0.001740 0.000523 0.00736
3.4 2510.00 0.1630 0.00597 0.002690 0.000691 0.01130
3.5 3160.00 0.1270 0.00909 0.004290 0.000679 0.01750
3.6 3980.00 0.0993 0.00928 0.004950 -0.000413 0.01900
3.7 5010.00 0.0799 0.00699 0.004820 -0.002460 0.01640

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.228 0.164 -0.09420 0.549
0.1 0.9920 1.26 0.234 0.173 -0.10500 0.573
0.2 0.9920 1.58 0.234 0.173 -0.10500 0.573
0.3 0.9920 2.00 0.234 0.173 -0.10500 0.573
0.4 0.9900 2.51 0.234 0.173 -0.10600 0.573
0.5 0.9880 3.16 0.234 0.173 -0.10600 0.573
0.6 0.9880 3.98 0.234 0.173 -0.10600 0.573
0.7 0.9870 5.01 0.234 0.173 -0.10600 0.574
0.8 0.9850 6.31 0.234 0.174 -0.10700 0.574
0.9 0.9810 7.94 0.234 0.174 -0.10700 0.574
1.0 0.9810 10.00 0.234 0.174 -0.10700 0.574
1.1 0.9810 12.60 0.234 0.174 -0.10700 0.574
1.2 0.9660 15.80 0.234 0.176 -0.11000 0.578
1.3 0.9660 20.00 0.234 0.176 -0.11000 0.578
1.4 0.9660 25.10 0.234 0.176 -0.11000 0.578
1.5 0.9660 31.60 0.234 0.176 -0.11000 0.578
1.6 0.9500 39.80 0.234 0.176 -0.11100 0.578
1.7 0.9440 50.10 0.234 0.177 -0.11200 0.580
1.8 0.9390 63.10 0.262 0.171 -0.07360 0.597
1.9 0.9290 79.40 0.273 0.170 -0.06020 0.606
2.0 0.8990 100.00 0.274 0.171 -0.06110 0.610
2.1 0.8850 126.00 0.324 0.164 0.00301 0.644
2.2 0.8550 158.00 0.363 0.159 0.05190 0.674
2.3 0.8420 200.00 0.401 0.153 0.10200 0.700
2.4 0.8180 251.00 0.451 0.145 0.16700 0.735
2.5 0.7640 316.00 0.488 0.141 0.21100 0.765
2.6 0.7150 398.00 0.502 0.143 0.22200 0.781
2.7 0.6380 501.00 0.510 0.144 0.22800 0.792
2.8 0.5210 631.00 0.510 0.159 0.19800 0.822
2.9 0.4700 794.00 0.510 0.171 0.17600 0.845
3.0 0.4320 1000.00 0.510 0.174 0.17000 0.850
3.1 0.3450 1260.00 0.510 0.186 0.14500 0.875
3.2 0.2870 1580.00 0.510 0.206 0.10700 0.913
3.3 0.2200 2000.00 0.510 0.237 0.04520 0.975
3.4 0.1630 2510.00 0.510 0.357 -0.19000 1.210
3.5 0.1270 3160.00 0.510 0.562 -0.59100 1.610
3.6 0.0993 3980.00 0.510 0.646 -0.75600 1.780
3.7 0.0799 5010.00 0.510 0.629 -0.72400 1.740

IgG_gp70V1V2AP

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00595 0.000929 0.004130 0.00777
0.1 0.998 1.26 0.00583 0.001020 0.003840 0.00783
0.2 0.998 1.58 0.00583 0.001020 0.003840 0.00783
0.3 0.998 2.00 0.00583 0.001020 0.003840 0.00783
0.4 0.997 2.51 0.00583 0.001020 0.003830 0.00783
0.5 0.997 3.16 0.00583 0.001020 0.003830 0.00783
0.6 0.992 3.98 0.00583 0.001020 0.003830 0.00784
0.7 0.986 5.01 0.00583 0.001030 0.003820 0.00785
0.8 0.982 6.31 0.00583 0.001030 0.003810 0.00786
0.9 0.972 7.94 0.00583 0.001030 0.003820 0.00785
1.0 0.972 10.00 0.00583 0.001030 0.003820 0.00785
1.1 0.972 12.60 0.00583 0.001030 0.003820 0.00785
1.2 0.972 15.80 0.00583 0.001030 0.003820 0.00785
1.3 0.954 20.00 0.00583 0.001050 0.003780 0.00789
1.4 0.946 25.10 0.00583 0.001060 0.003760 0.00791
1.5 0.945 31.60 0.00583 0.001040 0.003790 0.00788
1.6 0.935 39.80 0.00583 0.001050 0.003770 0.00789
1.7 0.917 50.10 0.00553 0.001020 0.003520 0.00754
1.8 0.905 63.10 0.00553 0.001040 0.003490 0.00756
1.9 0.886 79.40 0.00515 0.000990 0.003210 0.00709
2.0 0.842 100.00 0.00515 0.001040 0.003110 0.00719
2.1 0.787 126.00 0.00514 0.001070 0.003050 0.00724
2.2 0.725 158.00 0.00511 0.001100 0.002950 0.00727
2.3 0.659 200.00 0.00491 0.001050 0.002860 0.00696
2.4 0.609 251.00 0.00491 0.001110 0.002740 0.00707
2.5 0.521 316.00 0.00491 0.001280 0.002400 0.00742
2.6 0.456 398.00 0.00491 0.001410 0.002140 0.00767
2.7 0.395 501.00 0.00491 0.001600 0.001780 0.00804
2.8 0.335 631.00 0.00491 0.001640 0.001690 0.00812
2.9 0.256 794.00 0.00491 0.001780 0.001420 0.00840
3.0 0.201 1000.00 0.00491 0.002390 0.000221 0.00959
3.1 0.170 1260.00 0.00491 0.002340 0.000324 0.00949
3.2 0.120 1580.00 0.00491 0.003520 -0.001990 0.01180
3.3 0.091 2000.00 0.00491 0.004630 -0.004170 0.01400

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00595 0.000929 0.003920 0.00797
0.1 1.26 0.998 0.00581 0.001020 0.003810 0.00780
0.2 1.58 0.998 0.00581 0.001020 0.003810 0.00780
0.3 2.00 0.998 0.00581 0.001020 0.003810 0.00780
0.4 2.51 0.997 0.00581 0.001020 0.003810 0.00781
0.5 3.16 0.997 0.00581 0.001020 0.003810 0.00781
0.6 3.98 0.992 0.00583 0.001020 0.003830 0.00784
0.7 5.01 0.986 0.00587 0.001030 0.003850 0.00788
0.8 6.31 0.982 0.00589 0.001030 0.003870 0.00792
0.9 7.94 0.972 0.00579 0.001030 0.003780 0.00780
1.0 10.00 0.972 0.00579 0.001030 0.003780 0.00780
1.1 12.60 0.972 0.00579 0.001030 0.003780 0.00780
1.2 15.80 0.972 0.00579 0.001030 0.003780 0.00780
1.3 20.00 0.954 0.00591 0.001050 0.003860 0.00797
1.4 25.10 0.946 0.00596 0.001060 0.003890 0.00804
1.5 31.60 0.945 0.00581 0.001040 0.003770 0.00785
1.6 39.80 0.935 0.00586 0.001050 0.003790 0.00792
1.7 50.10 0.917 0.00549 0.001020 0.003490 0.00750
1.8 63.10 0.905 0.00556 0.001040 0.003530 0.00760
1.9 79.40 0.886 0.00503 0.000990 0.003090 0.00697
2.0 100.00 0.842 0.00527 0.001040 0.003230 0.00730
2.1 126.00 0.787 0.00514 0.001070 0.003050 0.00724
2.2 158.00 0.725 0.00511 0.001100 0.002950 0.00727
2.3 200.00 0.659 0.00431 0.001050 0.002260 0.00636
2.4 251.00 0.609 0.00443 0.001110 0.002260 0.00660
2.5 316.00 0.521 0.00494 0.001280 0.002430 0.00745
2.6 398.00 0.456 0.00513 0.001410 0.002360 0.00789
2.7 501.00 0.395 0.00558 0.001600 0.002450 0.00870
2.8 631.00 0.335 0.00534 0.001640 0.002120 0.00855
2.9 794.00 0.256 0.00457 0.001780 0.001080 0.00806
3.0 1000.00 0.201 0.00596 0.002390 0.001280 0.01060
3.1 1260.00 0.170 0.00521 0.002340 0.000621 0.00979
3.2 1580.00 0.120 0.00703 0.003520 0.000132 0.01390
3.3 2000.00 0.091 0.00707 0.004630 -0.002010 0.01610

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.228 0.164 -0.09420 0.549
0.1 0.998 1.26 0.242 0.172 -0.09380 0.579
0.2 0.998 1.58 0.242 0.172 -0.09380 0.579
0.3 0.998 2.00 0.242 0.172 -0.09380 0.579
0.4 0.997 2.51 0.242 0.172 -0.09410 0.579
0.5 0.997 3.16 0.242 0.172 -0.09410 0.579
0.6 0.992 3.98 0.242 0.172 -0.09490 0.580
0.7 0.986 5.01 0.242 0.173 -0.09570 0.581
0.8 0.982 6.31 0.242 0.173 -0.09660 0.582
0.9 0.972 7.94 0.242 0.172 -0.09550 0.580
1.0 0.972 10.00 0.242 0.172 -0.09550 0.580
1.1 0.972 12.60 0.242 0.172 -0.09550 0.580
1.2 0.972 15.80 0.242 0.172 -0.09550 0.580
1.3 0.954 20.00 0.242 0.175 -0.09960 0.585
1.4 0.946 25.10 0.242 0.176 -0.10200 0.587
1.5 0.945 31.60 0.243 0.174 -0.09820 0.583
1.6 0.935 39.80 0.243 0.175 -0.10000 0.585
1.7 0.917 50.10 0.282 0.169 -0.04820 0.612
1.8 0.905 63.10 0.282 0.170 -0.05100 0.615
1.9 0.886 79.40 0.332 0.161 0.01670 0.647
2.0 0.842 100.00 0.332 0.166 0.00639 0.657
2.1 0.787 126.00 0.332 0.169 0.00131 0.663
2.2 0.725 158.00 0.336 0.172 -0.00141 0.673
2.3 0.659 200.00 0.363 0.164 0.04120 0.684
2.4 0.609 251.00 0.363 0.170 0.02860 0.697
2.5 0.521 316.00 0.363 0.190 -0.00970 0.735
2.6 0.456 398.00 0.363 0.205 -0.03900 0.764
2.7 0.395 501.00 0.363 0.227 -0.08170 0.807
2.8 0.335 631.00 0.363 0.232 -0.09180 0.817
2.9 0.256 794.00 0.363 0.249 -0.12500 0.850
3.0 0.201 1000.00 0.363 0.324 -0.27200 0.997
3.1 0.170 1260.00 0.363 0.317 -0.25900 0.985
3.2 0.120 1580.00 0.363 0.466 -0.55100 1.280
3.3 0.091 2000.00 0.363 0.608 -0.83000 1.560

IgG_gp70V1V2C

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00595 0.000929 0.004130 0.00777
0.1 0.9880 1.26 0.00592 0.001030 0.003900 0.00794
0.2 0.9880 1.58 0.00592 0.001030 0.003900 0.00794
0.3 0.9880 2.00 0.00592 0.001030 0.003900 0.00794
0.4 0.9860 2.51 0.00592 0.001030 0.003890 0.00795
0.5 0.9840 3.16 0.00592 0.001040 0.003890 0.00795
0.6 0.9840 3.98 0.00592 0.001040 0.003890 0.00795
0.7 0.9820 5.01 0.00592 0.001040 0.003890 0.00795
0.8 0.9820 6.31 0.00592 0.001040 0.003890 0.00795
0.9 0.9760 7.94 0.00592 0.001040 0.003880 0.00796
1.0 0.9660 10.00 0.00592 0.001050 0.003860 0.00798
1.1 0.9590 12.60 0.00592 0.001060 0.003840 0.00800
1.2 0.9530 15.80 0.00592 0.001050 0.003860 0.00798
1.3 0.9410 20.00 0.00592 0.001070 0.003830 0.00801
1.4 0.9310 25.10 0.00574 0.001050 0.003690 0.00779
1.5 0.9220 31.60 0.00553 0.001020 0.003520 0.00754
1.6 0.9080 39.80 0.00553 0.001040 0.003490 0.00756
1.7 0.9010 50.10 0.00510 0.000990 0.003160 0.00704
1.8 0.8820 63.10 0.00491 0.000981 0.002990 0.00683
1.9 0.8550 79.40 0.00473 0.000970 0.002830 0.00663
2.0 0.8310 100.00 0.00473 0.000978 0.002820 0.00665
2.1 0.7940 126.00 0.00473 0.001020 0.002730 0.00674
2.2 0.7360 158.00 0.00461 0.001020 0.002610 0.00661
2.3 0.6760 200.00 0.00461 0.001050 0.002540 0.00667
2.4 0.6180 251.00 0.00461 0.001160 0.002330 0.00689
2.5 0.5660 316.00 0.00454 0.001160 0.002270 0.00680
2.6 0.5210 398.00 0.00454 0.001220 0.002150 0.00693
2.7 0.4440 501.00 0.00389 0.001220 0.001500 0.00627
2.8 0.3780 631.00 0.00387 0.001340 0.001240 0.00649
2.9 0.3070 794.00 0.00387 0.001220 0.001470 0.00627
3.0 0.2510 1000.00 0.00387 0.001420 0.001080 0.00665
3.1 0.2010 1260.00 0.00387 0.001570 0.000784 0.00695
3.2 0.1310 1580.00 0.00387 0.002690 -0.001410 0.00914
3.3 0.0791 2000.00 0.00387 0.003750 -0.003490 0.01120

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00595 0.000929 0.003920 0.00797
0.1 1.26 0.9880 0.00588 0.001030 0.003850 0.00790
0.2 1.58 0.9880 0.00588 0.001030 0.003850 0.00790
0.3 2.00 0.9880 0.00588 0.001030 0.003850 0.00790
0.4 2.51 0.9860 0.00588 0.001030 0.003860 0.00791
0.5 3.16 0.9840 0.00589 0.001040 0.003860 0.00792
0.6 3.98 0.9840 0.00589 0.001040 0.003860 0.00792
0.7 5.01 0.9820 0.00591 0.001040 0.003870 0.00794
0.8 6.31 0.9820 0.00591 0.001040 0.003870 0.00794
0.9 7.94 0.9760 0.00594 0.001040 0.003900 0.00798
1.0 10.00 0.9660 0.00599 0.001050 0.003930 0.00805
1.1 12.60 0.9590 0.00603 0.001060 0.003950 0.00811
1.2 15.80 0.9530 0.00591 0.001050 0.003850 0.00797
1.3 20.00 0.9410 0.00599 0.001070 0.003900 0.00808
1.4 25.10 0.9310 0.00574 0.001050 0.003690 0.00779
1.5 31.60 0.9220 0.00550 0.001020 0.003490 0.00751
1.6 39.80 0.9080 0.00556 0.001040 0.003530 0.00760
1.7 50.10 0.9010 0.00510 0.000990 0.003160 0.00704
1.8 63.10 0.8820 0.00491 0.000981 0.002990 0.00683
1.9 79.40 0.8550 0.00470 0.000970 0.002800 0.00660
2.0 100.00 0.8310 0.00465 0.000978 0.002740 0.00657
2.1 126.00 0.7940 0.00485 0.001020 0.002840 0.00685
2.2 158.00 0.7360 0.00457 0.001020 0.002570 0.00656
2.3 200.00 0.6760 0.00442 0.001050 0.002350 0.00648
2.4 251.00 0.6180 0.00485 0.001160 0.002570 0.00713
2.5 316.00 0.5660 0.00449 0.001160 0.002220 0.00676
2.6 398.00 0.5210 0.00459 0.001220 0.002200 0.00698
2.7 501.00 0.4440 0.00389 0.001220 0.001500 0.00627
2.8 631.00 0.3780 0.00386 0.001340 0.001240 0.00649
2.9 794.00 0.3070 0.00298 0.001220 0.000584 0.00538
3.0 1000.00 0.2510 0.00320 0.001420 0.000419 0.00599
3.1 1260.00 0.2010 0.00325 0.001570 0.000169 0.00633
3.2 1580.00 0.1310 0.00496 0.002690 -0.000318 0.01020
3.3 2000.00 0.0791 0.00600 0.003750 -0.001360 0.01340

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.228 0.164 -0.0942 0.549
0.1 0.9880 1.26 0.231 0.174 -0.1100 0.572
0.2 0.9880 1.58 0.231 0.174 -0.1100 0.572
0.3 0.9880 2.00 0.231 0.174 -0.1100 0.572
0.4 0.9860 2.51 0.231 0.174 -0.1100 0.572
0.5 0.9840 3.16 0.231 0.174 -0.1100 0.573
0.6 0.9840 3.98 0.231 0.174 -0.1100 0.573
0.7 0.9820 5.01 0.231 0.175 -0.1110 0.573
0.8 0.9820 6.31 0.231 0.175 -0.1110 0.573
0.9 0.9760 7.94 0.231 0.175 -0.1110 0.574
1.0 0.9660 10.00 0.231 0.176 -0.1130 0.576
1.1 0.9590 12.60 0.231 0.177 -0.1150 0.577
1.2 0.9530 15.80 0.231 0.176 -0.1130 0.576
1.3 0.9410 20.00 0.231 0.177 -0.1160 0.579
1.4 0.9310 25.10 0.254 0.173 -0.0852 0.594
1.5 0.9220 31.60 0.282 0.169 -0.0485 0.613
1.6 0.9080 39.80 0.282 0.170 -0.0512 0.615
1.7 0.9010 50.10 0.337 0.160 0.0234 0.651
1.8 0.8820 63.10 0.362 0.157 0.0543 0.670
1.9 0.8550 79.40 0.385 0.154 0.0836 0.687
2.0 0.8310 100.00 0.385 0.155 0.0819 0.689
2.1 0.7940 126.00 0.385 0.160 0.0726 0.698
2.2 0.7360 158.00 0.402 0.158 0.0919 0.711
2.3 0.6760 200.00 0.402 0.162 0.0848 0.719
2.4 0.6180 251.00 0.402 0.174 0.0608 0.743
2.5 0.5660 316.00 0.411 0.172 0.0725 0.749
2.6 0.5210 398.00 0.411 0.180 0.0579 0.763
2.7 0.4440 501.00 0.495 0.174 0.1540 0.836
2.8 0.3780 631.00 0.498 0.189 0.1280 0.868
2.9 0.3070 794.00 0.498 0.175 0.1560 0.840
3.0 0.2510 1000.00 0.498 0.198 0.1090 0.887
3.1 0.2010 1260.00 0.498 0.217 0.0735 0.923
3.2 0.1310 1580.00 0.498 0.357 -0.2020 1.200
3.3 0.0791 2000.00 0.498 0.493 -0.4680 1.460

IgG_gp70BCaseA2V1V2169K

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00595 0.000929 0.004130 0.00777
0.1 0.9980 1.26 0.00584 0.001020 0.003840 0.00784
0.2 0.9980 1.58 0.00584 0.001020 0.003840 0.00784
0.3 0.9980 2.00 0.00584 0.001020 0.003840 0.00784
0.4 0.9970 2.51 0.00584 0.001020 0.003840 0.00784
0.5 0.9950 3.16 0.00584 0.001020 0.003840 0.00784
0.6 0.9950 3.98 0.00584 0.001020 0.003840 0.00784
0.7 0.9940 5.01 0.00584 0.001020 0.003830 0.00784
0.8 0.9940 6.31 0.00584 0.001020 0.003830 0.00784
0.9 0.9900 7.94 0.00584 0.001030 0.003830 0.00785
1.0 0.9890 10.00 0.00584 0.001030 0.003820 0.00785
1.1 0.9890 12.60 0.00584 0.001030 0.003820 0.00785
1.2 0.9890 15.80 0.00584 0.001030 0.003820 0.00785
1.3 0.9810 20.00 0.00584 0.001030 0.003810 0.00787
1.4 0.9740 25.10 0.00584 0.001040 0.003790 0.00788
1.5 0.9690 31.60 0.00582 0.001030 0.003800 0.00784
1.6 0.9650 39.80 0.00582 0.001040 0.003790 0.00784
1.7 0.9630 50.10 0.00569 0.001020 0.003690 0.00769
1.8 0.9580 63.10 0.00557 0.001010 0.003590 0.00755
1.9 0.9420 79.40 0.00536 0.000997 0.003410 0.00732
2.0 0.9420 100.00 0.00521 0.000981 0.003290 0.00713
2.1 0.9370 126.00 0.00510 0.000972 0.003190 0.00700
2.2 0.9190 158.00 0.00505 0.000979 0.003130 0.00697
2.3 0.8900 200.00 0.00470 0.000952 0.002830 0.00656
2.4 0.8720 251.00 0.00460 0.000948 0.002750 0.00646
2.5 0.8320 316.00 0.00449 0.000949 0.002630 0.00635
2.6 0.7830 398.00 0.00449 0.000985 0.002560 0.00642
2.7 0.7210 501.00 0.00449 0.001030 0.002480 0.00650
2.8 0.6690 631.00 0.00444 0.001060 0.002370 0.00652
2.9 0.6140 794.00 0.00438 0.001100 0.002230 0.00653
3.0 0.5430 1000.00 0.00433 0.001150 0.002070 0.00659
3.1 0.5020 1260.00 0.00433 0.001260 0.001850 0.00681
3.2 0.4000 1580.00 0.00432 0.001380 0.001600 0.00703
3.3 0.3380 2000.00 0.00425 0.001520 0.001280 0.00722
3.4 0.2650 2510.00 0.00425 0.001650 0.001030 0.00748
3.5 0.2050 3160.00 0.00425 0.002260 -0.000171 0.00868
3.6 0.1490 3980.00 0.00384 0.001680 0.000547 0.00714
3.7 0.1310 5010.00 0.00384 0.002150 -0.000370 0.00805
3.8 0.0971 6310.00 0.00384 0.002740 -0.001530 0.00921

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00595 0.000929 0.003920 0.00797
0.1 1.26 0.9980 0.00581 0.001020 0.003810 0.00780
0.2 1.58 0.9980 0.00581 0.001020 0.003810 0.00780
0.3 2.00 0.9980 0.00581 0.001020 0.003810 0.00780
0.4 2.51 0.9970 0.00581 0.001020 0.003810 0.00781
0.5 3.16 0.9950 0.00582 0.001020 0.003820 0.00782
0.6 3.98 0.9950 0.00582 0.001020 0.003820 0.00782
0.7 5.01 0.9940 0.00583 0.001020 0.003820 0.00783
0.8 6.31 0.9940 0.00583 0.001020 0.003820 0.00783
0.9 7.94 0.9900 0.00584 0.001030 0.003830 0.00785
1.0 10.00 0.9890 0.00585 0.001030 0.003840 0.00787
1.1 12.60 0.9890 0.00585 0.001030 0.003840 0.00787
1.2 15.80 0.9890 0.00585 0.001030 0.003840 0.00787
1.3 20.00 0.9810 0.00589 0.001030 0.003860 0.00791
1.4 25.10 0.9740 0.00592 0.001040 0.003880 0.00797
1.5 31.60 0.9690 0.00580 0.001030 0.003780 0.00782
1.6 39.80 0.9650 0.00583 0.001040 0.003800 0.00786
1.7 50.10 0.9630 0.00569 0.001020 0.003690 0.00769
1.8 63.10 0.9580 0.00557 0.001010 0.003590 0.00755
1.9 79.40 0.9420 0.00536 0.000997 0.003410 0.00732
2.0 100.00 0.9420 0.00521 0.000981 0.003290 0.00713
2.1 126.00 0.9370 0.00510 0.000972 0.003190 0.00700
2.2 158.00 0.9190 0.00505 0.000979 0.003130 0.00697
2.3 200.00 0.8900 0.00470 0.000952 0.002830 0.00656
2.4 251.00 0.8720 0.00460 0.000948 0.002750 0.00646
2.5 316.00 0.8320 0.00445 0.000949 0.002590 0.00631
2.6 398.00 0.7830 0.00451 0.000985 0.002580 0.00644
2.7 501.00 0.7210 0.00452 0.001030 0.002500 0.00653
2.8 631.00 0.6690 0.00444 0.001060 0.002370 0.00652
2.9 794.00 0.6140 0.00438 0.001100 0.002230 0.00653
3.0 1000.00 0.5430 0.00422 0.001150 0.001960 0.00648
3.1 1260.00 0.5020 0.00445 0.001260 0.001970 0.00693
3.2 1580.00 0.4000 0.00432 0.001380 0.001600 0.00703
3.3 2000.00 0.3380 0.00425 0.001520 0.001280 0.00722
3.4 2510.00 0.2650 0.00418 0.001650 0.000954 0.00740
3.5 3160.00 0.2050 0.00515 0.002260 0.000727 0.00958
3.6 3980.00 0.1490 0.00314 0.001680 -0.000156 0.00643
3.7 5010.00 0.1310 0.00397 0.002150 -0.000243 0.00818
3.8 6310.00 0.0971 0.00442 0.002740 -0.000948 0.00979

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.228 0.164 -0.09420 0.549
0.1 0.9980 1.26 0.242 0.172 -0.09450 0.578
0.2 0.9980 1.58 0.242 0.172 -0.09450 0.578
0.3 0.9980 2.00 0.242 0.172 -0.09450 0.578
0.4 0.9970 2.51 0.242 0.172 -0.09470 0.579
0.5 0.9950 3.16 0.242 0.172 -0.09500 0.579
0.6 0.9950 3.98 0.242 0.172 -0.09500 0.579
0.7 0.9940 5.01 0.242 0.172 -0.09530 0.579
0.8 0.9940 6.31 0.242 0.172 -0.09530 0.579
0.9 0.9900 7.94 0.242 0.172 -0.09590 0.580
1.0 0.9890 10.00 0.242 0.172 -0.09620 0.580
1.1 0.9890 12.60 0.242 0.172 -0.09620 0.580
1.2 0.9890 15.80 0.242 0.172 -0.09620 0.580
1.3 0.9810 20.00 0.242 0.173 -0.09760 0.581
1.4 0.9740 25.10 0.242 0.174 -0.09910 0.583
1.5 0.9690 31.60 0.245 0.173 -0.09330 0.583
1.6 0.9650 39.80 0.245 0.173 -0.09430 0.584
1.7 0.9630 50.10 0.261 0.170 -0.07260 0.594
1.8 0.9580 63.10 0.277 0.168 -0.05130 0.605
1.9 0.9420 79.40 0.304 0.164 -0.01770 0.625
2.0 0.9420 100.00 0.323 0.160 0.00888 0.638
2.1 0.9370 126.00 0.338 0.158 0.02790 0.648
2.2 0.9190 158.00 0.344 0.158 0.03360 0.655
2.3 0.8900 200.00 0.390 0.152 0.09260 0.687
2.4 0.8720 251.00 0.402 0.150 0.10800 0.697
2.5 0.8320 316.00 0.417 0.149 0.12500 0.709
2.6 0.7830 398.00 0.417 0.153 0.11700 0.717
2.7 0.7210 501.00 0.417 0.158 0.10800 0.726
2.8 0.6690 631.00 0.423 0.161 0.10800 0.738
2.9 0.6140 794.00 0.431 0.164 0.11000 0.753
3.0 0.5430 1000.00 0.437 0.170 0.10400 0.771
3.1 0.5020 1260.00 0.437 0.183 0.07850 0.796
3.2 0.4000 1580.00 0.439 0.197 0.05310 0.826
3.3 0.3380 2000.00 0.447 0.212 0.03140 0.864
3.4 0.2650 2510.00 0.447 0.228 0.00059 0.894
3.5 0.2050 3160.00 0.447 0.304 -0.14800 1.040
3.6 0.1490 3980.00 0.501 0.230 0.05070 0.952
3.7 0.1310 5010.00 0.501 0.288 -0.06360 1.070
3.8 0.0971 6310.00 0.501 0.363 -0.21000 1.210

IgG_gp70BCaseA2V1V2mut3

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00597 0.000929 0.00415 0.00779
0.1 0.997 1.26 0.00597 0.001030 0.00394 0.00799
0.2 0.997 1.58 0.00597 0.001030 0.00394 0.00799
0.3 0.997 2.00 0.00597 0.001030 0.00394 0.00799
0.4 0.997 2.51 0.00597 0.001030 0.00394 0.00799
0.5 0.997 3.16 0.00597 0.001030 0.00394 0.00799
0.6 0.995 3.98 0.00597 0.001040 0.00394 0.00800
0.7 0.994 5.01 0.00597 0.001040 0.00393 0.00800
0.8 0.994 6.31 0.00597 0.001040 0.00393 0.00800
0.9 0.992 7.94 0.00597 0.001040 0.00393 0.00800
1.0 0.992 10.00 0.00597 0.001040 0.00393 0.00800
1.1 0.992 12.60 0.00597 0.001040 0.00393 0.00800
1.2 0.992 15.80 0.00597 0.001040 0.00393 0.00800
1.3 0.992 20.00 0.00584 0.001020 0.00383 0.00785
1.4 0.992 25.10 0.00584 0.001020 0.00383 0.00785
1.5 0.992 31.60 0.00584 0.001020 0.00383 0.00785
1.6 0.990 39.80 0.00584 0.001030 0.00383 0.00785
1.7 0.990 50.10 0.00584 0.001030 0.00383 0.00785
1.8 0.990 63.10 0.00584 0.001030 0.00383 0.00785
1.9 0.990 79.40 0.00584 0.001030 0.00383 0.00785
2.0 0.990 100.00 0.00584 0.001030 0.00383 0.00785
2.1 0.990 126.00 0.00584 0.001030 0.00383 0.00785
2.2 0.990 158.00 0.00584 0.001030 0.00383 0.00785
2.3 0.989 200.00 0.00584 0.001030 0.00382 0.00786
2.4 0.987 251.00 0.00573 0.001020 0.00374 0.00772
2.5 0.987 316.00 0.00573 0.001020 0.00374 0.00772
2.6 0.987 398.00 0.00573 0.001020 0.00374 0.00772
2.7 0.987 501.00 0.00573 0.001020 0.00374 0.00772
2.8 0.981 631.00 0.00573 0.001020 0.00373 0.00773
2.9 0.981 794.00 0.00573 0.001020 0.00373 0.00773
3.0 0.981 1000.00 0.00562 0.001010 0.00365 0.00759
3.1 0.976 1260.00 0.00562 0.001010 0.00364 0.00760
3.2 0.976 1580.00 0.00549 0.000996 0.00354 0.00744
3.3 0.967 2000.00 0.00541 0.000990 0.00347 0.00735
3.4 0.963 2510.00 0.00541 0.000994 0.00346 0.00736
3.5 0.963 3160.00 0.00527 0.000978 0.00335 0.00719
3.6 0.956 3980.00 0.00519 0.000968 0.00329 0.00708
3.7 0.940 5010.00 0.00519 0.000939 0.00335 0.00702
3.8 0.922 6310.00 0.00519 0.000956 0.00331 0.00706
3.9 0.912 7940.00 0.00519 0.000969 0.00329 0.00708
4.0 0.830 10000.00 0.00519 0.001030 0.00316 0.00721
4.1 0.746 12600.00 0.00519 0.001130 0.00296 0.00741
4.2 0.673 15800.00 0.00519 0.001190 0.00284 0.00753
4.3 0.550 20000.00 0.00519 0.001410 0.00243 0.00794
4.4 0.323 25100.00 0.00519 0.001870 0.00152 0.00885

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00595 0.000929 0.00392 0.00797
0.1 1.26 0.997 0.00596 0.001030 0.00393 0.00799
0.2 1.58 0.997 0.00596 0.001030 0.00393 0.00799
0.3 2.00 0.997 0.00596 0.001030 0.00393 0.00799
0.4 2.51 0.997 0.00596 0.001030 0.00393 0.00799
0.5 3.16 0.997 0.00596 0.001030 0.00393 0.00799
0.6 3.98 0.995 0.00596 0.001040 0.00393 0.00800
0.7 5.01 0.994 0.00597 0.001040 0.00394 0.00800
0.8 6.31 0.994 0.00597 0.001040 0.00394 0.00800
0.9 7.94 0.992 0.00598 0.001040 0.00394 0.00802
1.0 10.00 0.992 0.00598 0.001040 0.00394 0.00802
1.1 12.60 0.992 0.00598 0.001040 0.00394 0.00802
1.2 15.80 0.992 0.00598 0.001040 0.00394 0.00802
1.3 20.00 0.992 0.00583 0.001020 0.00383 0.00784
1.4 25.10 0.992 0.00583 0.001020 0.00383 0.00784
1.5 31.60 0.992 0.00583 0.001020 0.00383 0.00784
1.6 39.80 0.990 0.00584 0.001030 0.00383 0.00785
1.7 50.10 0.990 0.00584 0.001030 0.00383 0.00785
1.8 63.10 0.990 0.00584 0.001030 0.00383 0.00785
1.9 79.40 0.990 0.00584 0.001030 0.00383 0.00785
2.0 100.00 0.990 0.00584 0.001030 0.00383 0.00785
2.1 126.00 0.990 0.00584 0.001030 0.00383 0.00785
2.2 158.00 0.990 0.00584 0.001030 0.00383 0.00785
2.3 200.00 0.989 0.00586 0.001030 0.00384 0.00787
2.4 251.00 0.987 0.00572 0.001020 0.00373 0.00771
2.5 316.00 0.987 0.00572 0.001020 0.00373 0.00771
2.6 398.00 0.987 0.00572 0.001020 0.00373 0.00771
2.7 501.00 0.987 0.00572 0.001020 0.00373 0.00771
2.8 631.00 0.981 0.00575 0.001020 0.00374 0.00775
2.9 794.00 0.981 0.00575 0.001020 0.00374 0.00775
3.0 1000.00 0.981 0.00560 0.001010 0.00363 0.00758
3.1 1260.00 0.976 0.00564 0.001010 0.00366 0.00762
3.2 1580.00 0.976 0.00549 0.000996 0.00354 0.00744
3.3 2000.00 0.967 0.00540 0.000990 0.00346 0.00734
3.4 2510.00 0.963 0.00542 0.000994 0.00347 0.00737
3.5 3160.00 0.963 0.00527 0.000978 0.00335 0.00719
3.6 3980.00 0.956 0.00515 0.000968 0.00325 0.00705
3.7 5010.00 0.940 0.00479 0.000939 0.00295 0.00663
3.8 6310.00 0.922 0.00487 0.000956 0.00300 0.00675
3.9 7940.00 0.912 0.00493 0.000969 0.00303 0.00683
4.0 10000.00 0.830 0.00507 0.001030 0.00305 0.00710
4.1 12600.00 0.746 0.00544 0.001130 0.00322 0.00766
4.2 15800.00 0.673 0.00541 0.001190 0.00307 0.00775
4.3 20000.00 0.550 0.00593 0.001410 0.00317 0.00868
4.4 25100.00 0.323 0.00536 0.001870 0.00170 0.00903

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.225 0.164 -0.096900 0.548
0.1 0.997 1.26 0.225 0.175 -0.117000 0.568
0.2 0.997 1.58 0.225 0.175 -0.117000 0.568
0.3 0.997 2.00 0.225 0.175 -0.117000 0.568
0.4 0.997 2.51 0.225 0.175 -0.117000 0.568
0.5 0.997 3.16 0.225 0.175 -0.117000 0.568
0.6 0.995 3.98 0.225 0.175 -0.117000 0.568
0.7 0.994 5.01 0.225 0.175 -0.118000 0.568
0.8 0.994 6.31 0.225 0.175 -0.118000 0.568
0.9 0.992 7.94 0.225 0.175 -0.118000 0.569
1.0 0.992 10.00 0.225 0.175 -0.118000 0.569
1.1 0.992 12.60 0.225 0.175 -0.118000 0.569
1.2 0.992 15.80 0.225 0.175 -0.118000 0.569
1.3 0.992 20.00 0.241 0.172 -0.096000 0.579
1.4 0.992 25.10 0.241 0.172 -0.096000 0.579
1.5 0.992 31.60 0.241 0.172 -0.096000 0.579
1.6 0.990 39.80 0.241 0.172 -0.096400 0.579
1.7 0.990 50.10 0.241 0.172 -0.096400 0.579
1.8 0.990 63.10 0.241 0.172 -0.096400 0.579
1.9 0.990 79.40 0.241 0.172 -0.096400 0.579
2.0 0.990 100.00 0.241 0.172 -0.096400 0.579
2.1 0.990 126.00 0.241 0.172 -0.096400 0.579
2.2 0.990 158.00 0.241 0.172 -0.096400 0.579
2.3 0.989 200.00 0.241 0.173 -0.096900 0.580
2.4 0.987 251.00 0.256 0.170 -0.076900 0.589
2.5 0.987 316.00 0.256 0.170 -0.076900 0.589
2.6 0.987 398.00 0.256 0.170 -0.076900 0.589
2.7 0.987 501.00 0.256 0.170 -0.076900 0.589
2.8 0.981 631.00 0.256 0.171 -0.078000 0.590
2.9 0.981 794.00 0.256 0.171 -0.078000 0.590
3.0 0.981 1000.00 0.270 0.168 -0.058700 0.599
3.1 0.976 1260.00 0.270 0.168 -0.059600 0.600
3.2 0.976 1580.00 0.287 0.165 -0.037100 0.611
3.3 0.967 2000.00 0.298 0.164 -0.023000 0.619
3.4 0.963 2510.00 0.298 0.164 -0.023800 0.619
3.5 0.963 3160.00 0.316 0.161 0.000465 0.631
3.6 0.956 3980.00 0.327 0.159 0.015300 0.638
3.7 0.940 5010.00 0.327 0.156 0.021300 0.632
3.8 0.922 6310.00 0.327 0.158 0.017800 0.636
3.9 0.912 7940.00 0.327 0.159 0.015200 0.638
4.0 0.830 10000.00 0.327 0.166 0.002090 0.651
4.1 0.746 12600.00 0.327 0.176 -0.019100 0.673
4.2 0.673 15800.00 0.327 0.183 -0.031900 0.685
4.3 0.550 20000.00 0.327 0.207 -0.078800 0.732
4.4 0.323 25100.00 0.327 0.262 -0.186000 0.839

IgG3_A244D11K169

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00596 0.000929 0.004140 0.00778
0.1 0.9940 1.26 0.00596 0.001040 0.003930 0.00799
0.2 0.9940 1.58 0.00586 0.001020 0.003850 0.00786
0.3 0.9940 2.00 0.00586 0.001020 0.003850 0.00786
0.4 0.9890 2.51 0.00586 0.001030 0.003840 0.00787
0.5 0.9880 3.16 0.00586 0.001030 0.003840 0.00788
0.6 0.9880 3.98 0.00586 0.001030 0.003840 0.00788
0.7 0.9860 5.01 0.00584 0.001020 0.003850 0.00783
0.8 0.9790 6.31 0.00584 0.001010 0.003870 0.00781
0.9 0.9790 7.94 0.00584 0.001010 0.003870 0.00781
1.0 0.9790 10.00 0.00584 0.001010 0.003870 0.00781
1.1 0.9670 12.60 0.00584 0.001020 0.003850 0.00784
1.2 0.9610 15.80 0.00584 0.001030 0.003830 0.00785
1.3 0.9520 20.00 0.00584 0.001020 0.003840 0.00784
1.4 0.9390 25.10 0.00584 0.001040 0.003810 0.00787
1.5 0.9200 31.60 0.00584 0.001060 0.003770 0.00791
1.6 0.9040 39.80 0.00584 0.001080 0.003730 0.00795
1.7 0.8800 50.10 0.00584 0.001090 0.003710 0.00798
1.8 0.8500 63.10 0.00584 0.001090 0.003700 0.00798
1.9 0.8010 79.40 0.00584 0.001150 0.003600 0.00809
2.0 0.7590 100.00 0.00584 0.001120 0.003640 0.00804
2.1 0.6720 126.00 0.00584 0.001150 0.003590 0.00809
2.2 0.5800 158.00 0.00584 0.001290 0.003320 0.00837
2.3 0.4950 200.00 0.00584 0.001550 0.002800 0.00888
2.4 0.3620 251.00 0.00584 0.001730 0.002440 0.00924
2.5 0.2880 316.00 0.00584 0.002090 0.001740 0.00995
2.6 0.2260 398.00 0.00584 0.002380 0.001180 0.01050
2.7 0.1860 501.00 0.00584 0.002690 0.000562 0.01110
2.8 0.1310 631.00 0.00584 0.003070 -0.000173 0.01190
2.9 0.0839 794.00 0.00584 0.004060 -0.002120 0.01380
3.0 0.0608 1000.00 0.00584 0.006410 -0.006720 0.01840
3.1 0.0519 1260.00 0.00584 0.006030 -0.005980 0.01770
3.2 0.0462 1580.00 0.00584 0.009500 -0.012800 0.02450
3.3 0.0285 2000.00 0.00584 0.024500 -0.042300 0.05390
3.4 0.0183 2510.00 0.00584 0.035600 -0.063800 0.07550
3.5 0.0093 3160.00 0.00584 0.049700 -0.091600 0.10300

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00595 0.000929 0.003920 0.00797
0.1 1.26 0.9940 0.00597 0.001040 0.003940 0.00801
0.2 1.58 0.9940 0.00583 0.001020 0.003820 0.00783
0.3 2.00 0.9940 0.00583 0.001020 0.003820 0.00783
0.4 2.51 0.9890 0.00587 0.001030 0.003850 0.00788
0.5 3.16 0.9880 0.00588 0.001030 0.003860 0.00790
0.6 3.98 0.9880 0.00588 0.001030 0.003860 0.00790
0.7 5.01 0.9860 0.00574 0.001020 0.003750 0.00773
0.8 6.31 0.9790 0.00562 0.001010 0.003650 0.00760
0.9 7.94 0.9790 0.00562 0.001010 0.003650 0.00760
1.0 10.00 0.9790 0.00562 0.001010 0.003650 0.00760
1.1 12.60 0.9670 0.00568 0.001020 0.003680 0.00768
1.2 15.80 0.9610 0.00573 0.001030 0.003710 0.00774
1.3 20.00 0.9520 0.00562 0.001020 0.003620 0.00762
1.4 25.10 0.9390 0.00571 0.001040 0.003680 0.00774
1.5 31.60 0.9200 0.00581 0.001060 0.003740 0.00788
1.6 39.80 0.9040 0.00591 0.001080 0.003800 0.00802
1.7 50.10 0.8800 0.00590 0.001090 0.003770 0.00804
1.8 63.10 0.8500 0.00576 0.001090 0.003620 0.00790
1.9 79.40 0.8010 0.00595 0.001150 0.003700 0.00819
2.0 100.00 0.7590 0.00549 0.001120 0.003290 0.00769
2.1 126.00 0.6720 0.00512 0.001150 0.002870 0.00738
2.2 158.00 0.5800 0.00545 0.001290 0.002920 0.00797
2.3 200.00 0.4950 0.00633 0.001550 0.003290 0.00937
2.4 251.00 0.3620 0.00599 0.001730 0.002600 0.00939
2.5 316.00 0.2880 0.00684 0.002090 0.002740 0.01090
2.6 398.00 0.2260 0.00716 0.002380 0.002490 0.01180
2.7 501.00 0.1860 0.00737 0.002690 0.002100 0.01270
2.8 631.00 0.1310 0.00692 0.003070 0.000906 0.01290
2.9 794.00 0.0839 0.00811 0.004060 0.000158 0.01610
3.0 1000.00 0.0608 0.00982 0.006410 -0.002740 0.02240
3.1 1260.00 0.0519 0.00935 0.006030 -0.002470 0.02120
3.2 1580.00 0.0462 0.01210 0.009500 -0.006540 0.03070
3.3 2000.00 0.0285 0.03600 0.024500 -0.012100 0.08410
3.4 2510.00 0.0183 0.07070 0.035600 0.001010 0.14000
3.5 3160.00 0.0093 0.14500 0.049700 0.047300 0.24200

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.226 0.164 -0.0960 0.548
0.1 0.9940 1.26 0.226 0.175 -0.1170 0.569
0.2 0.9940 1.58 0.240 0.172 -0.0982 0.577
0.3 0.9940 2.00 0.240 0.172 -0.0982 0.577
0.4 0.9890 2.51 0.240 0.173 -0.0991 0.578
0.5 0.9880 3.16 0.240 0.173 -0.0995 0.579
0.6 0.9880 3.98 0.240 0.173 -0.0995 0.579
0.7 0.9860 5.01 0.242 0.171 -0.0944 0.577
0.8 0.9790 6.31 0.242 0.170 -0.0926 0.576
0.9 0.9790 7.94 0.242 0.170 -0.0926 0.576
1.0 0.9790 10.00 0.242 0.170 -0.0926 0.576
1.1 0.9670 12.60 0.242 0.172 -0.0948 0.578
1.2 0.9610 15.80 0.242 0.173 -0.0966 0.580
1.3 0.9520 20.00 0.242 0.172 -0.0950 0.578
1.4 0.9390 25.10 0.242 0.173 -0.0984 0.581
1.5 0.9200 31.60 0.242 0.175 -0.1020 0.585
1.6 0.9040 39.80 0.242 0.177 -0.1060 0.589
1.7 0.8800 50.10 0.242 0.179 -0.1090 0.592
1.8 0.8500 63.10 0.242 0.179 -0.1090 0.592
1.9 0.8010 79.40 0.242 0.185 -0.1200 0.603
2.0 0.7590 100.00 0.242 0.182 -0.1160 0.599
2.1 0.6720 126.00 0.242 0.185 -0.1210 0.604
2.2 0.5800 158.00 0.242 0.200 -0.1500 0.633
2.3 0.4950 200.00 0.242 0.229 -0.2080 0.691
2.4 0.3620 251.00 0.242 0.250 -0.2490 0.732
2.5 0.2880 316.00 0.242 0.293 -0.3330 0.816
2.6 0.2260 398.00 0.242 0.328 -0.4010 0.884
2.7 0.1860 501.00 0.242 0.366 -0.4770 0.960
2.8 0.1310 631.00 0.242 0.413 -0.5680 1.050
2.9 0.0839 794.00 0.242 0.538 -0.8140 1.300
3.0 0.0608 1000.00 0.242 0.839 -1.4000 1.890
3.1 0.0519 1260.00 0.242 0.791 -1.3100 1.790
3.2 0.0462 1580.00 0.242 1.240 -2.1900 2.670
3.3 0.0285 2000.00 0.242 3.190 -6.0100 6.490
3.4 0.0183 2510.00 0.242 4.620 -8.8100 9.290
3.5 0.0093 3160.00 0.242 6.450 -12.4000 12.900

IgG3_gp70ClAEV1V2

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00595 0.000929 0.004130 0.00777
0.1 0.9850 1.26 0.00582 0.001010 0.003830 0.00780
0.2 0.9850 1.58 0.00582 0.001010 0.003830 0.00780
0.3 0.9850 2.00 0.00582 0.001010 0.003830 0.00780
0.4 0.9830 2.51 0.00582 0.001010 0.003830 0.00781
0.5 0.9820 3.16 0.00582 0.001020 0.003830 0.00781
0.6 0.9820 3.98 0.00582 0.001020 0.003830 0.00781
0.7 0.9820 5.01 0.00582 0.001020 0.003830 0.00781
0.8 0.9770 6.31 0.00582 0.001020 0.003820 0.00782
0.9 0.9730 7.94 0.00582 0.001030 0.003810 0.00783
1.0 0.9730 10.00 0.00582 0.001030 0.003810 0.00783
1.1 0.9660 12.60 0.00582 0.001030 0.003800 0.00784
1.2 0.9660 15.80 0.00582 0.001030 0.003800 0.00784
1.3 0.9660 20.00 0.00582 0.001030 0.003800 0.00784
1.4 0.9660 25.10 0.00582 0.001030 0.003800 0.00784
1.5 0.9620 31.60 0.00582 0.001030 0.003790 0.00785
1.6 0.9510 39.80 0.00582 0.001020 0.003830 0.00781
1.7 0.9470 50.10 0.00582 0.001020 0.003820 0.00782
1.8 0.9450 63.10 0.00582 0.001020 0.003820 0.00782
1.9 0.9360 79.40 0.00582 0.001030 0.003790 0.00785
2.0 0.9290 100.00 0.00582 0.001040 0.003780 0.00786
2.1 0.9100 126.00 0.00582 0.001030 0.003800 0.00784
2.2 0.8860 158.00 0.00582 0.001060 0.003730 0.00791
2.3 0.8750 200.00 0.00582 0.001080 0.003710 0.00793
2.4 0.8610 251.00 0.00582 0.001060 0.003750 0.00789
2.5 0.8310 316.00 0.00582 0.001070 0.003710 0.00792
2.6 0.8040 398.00 0.00582 0.001100 0.003670 0.00797
2.7 0.7140 501.00 0.00582 0.001190 0.003480 0.00816
2.8 0.6780 631.00 0.00582 0.001220 0.003420 0.00822
2.9 0.6350 794.00 0.00582 0.001260 0.003350 0.00829
3.0 0.5780 1000.00 0.00582 0.001360 0.003160 0.00848
3.1 0.5070 1260.00 0.00582 0.001470 0.002930 0.00871
3.2 0.4410 1580.00 0.00582 0.001640 0.002600 0.00904
3.3 0.3480 2000.00 0.00582 0.001840 0.002220 0.00942
3.4 0.3030 2510.00 0.00582 0.002060 0.001790 0.00985
3.5 0.2460 3160.00 0.00582 0.002450 0.001010 0.01060
3.6 0.1980 3980.00 0.00582 0.002820 0.000283 0.01140
3.7 0.1560 5010.00 0.00582 0.003560 -0.001160 0.01280
3.8 0.1080 6310.00 0.00582 0.004320 -0.002640 0.01430
3.9 0.0747 7940.00 0.00582 0.005710 -0.005380 0.01700
4.0 0.0655 10000.00 0.00582 0.006590 -0.007100 0.01870
4.1 0.0609 12600.00 0.00582 0.005650 -0.005260 0.01690
4.2 0.0451 15800.00 0.00582 0.007840 -0.009540 0.02120

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00595 0.000929 0.003920 0.00797
0.1 1.26 0.9850 0.00572 0.001010 0.003730 0.00770
0.2 1.58 0.9850 0.00572 0.001010 0.003730 0.00770
0.3 2.00 0.9850 0.00572 0.001010 0.003730 0.00770
0.4 2.51 0.9830 0.00573 0.001010 0.003740 0.00771
0.5 3.16 0.9820 0.00573 0.001020 0.003740 0.00772
0.6 3.98 0.9820 0.00573 0.001020 0.003740 0.00772
0.7 5.01 0.9820 0.00573 0.001020 0.003740 0.00772
0.8 6.31 0.9770 0.00576 0.001020 0.003760 0.00776
0.9 7.94 0.9730 0.00578 0.001030 0.003770 0.00779
1.0 10.00 0.9730 0.00578 0.001030 0.003770 0.00779
1.1 12.60 0.9660 0.00581 0.001030 0.003790 0.00784
1.2 15.80 0.9660 0.00581 0.001030 0.003790 0.00784
1.3 20.00 0.9660 0.00581 0.001030 0.003790 0.00784
1.4 25.10 0.9660 0.00581 0.001030 0.003790 0.00784
1.5 31.60 0.9620 0.00583 0.001030 0.003810 0.00786
1.6 39.80 0.9510 0.00560 0.001020 0.003610 0.00759
1.7 50.10 0.9470 0.00562 0.001020 0.003620 0.00762
1.8 63.10 0.9450 0.00563 0.001020 0.003630 0.00763
1.9 79.40 0.9360 0.00569 0.001030 0.003670 0.00772
2.0 100.00 0.9290 0.00573 0.001040 0.003690 0.00777
2.1 126.00 0.9100 0.00553 0.001030 0.003510 0.00755
2.2 158.00 0.8860 0.00569 0.001060 0.003610 0.00778
2.3 200.00 0.8750 0.00575 0.001080 0.003640 0.00786
2.4 251.00 0.8610 0.00551 0.001060 0.003440 0.00758
2.5 316.00 0.8310 0.00550 0.001070 0.003400 0.00761
2.6 398.00 0.8040 0.00553 0.001100 0.003380 0.00768
2.7 501.00 0.7140 0.00567 0.001190 0.003330 0.00802
2.8 631.00 0.6780 0.00574 0.001220 0.003340 0.00813
2.9 794.00 0.6350 0.00570 0.001260 0.003220 0.00817
3.0 1000.00 0.5780 0.00597 0.001360 0.003320 0.00863
3.1 1260.00 0.5070 0.00607 0.001470 0.003190 0.00896
3.2 1580.00 0.4410 0.00642 0.001640 0.003200 0.00965
3.3 2000.00 0.3480 0.00636 0.001840 0.002760 0.00996
3.4 2510.00 0.3030 0.00660 0.002060 0.002560 0.01060
3.5 3160.00 0.2460 0.00738 0.002450 0.002580 0.01220
3.6 3980.00 0.1980 0.00783 0.002820 0.002300 0.01340
3.7 5010.00 0.1560 0.00926 0.003560 0.002280 0.01620
3.8 6310.00 0.1080 0.00960 0.004320 0.001130 0.01810
3.9 7940.00 0.0747 0.01150 0.005710 0.000331 0.02270
4.0 10000.00 0.0655 0.01110 0.006590 -0.001830 0.02400
4.1 12600.00 0.0609 0.00847 0.005650 -0.002610 0.01950
4.2 15800.00 0.0451 0.01110 0.007840 -0.004290 0.02640

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.228 0.164 -0.0942 0.549
0.1 0.9850 1.26 0.244 0.171 -0.0904 0.579
0.2 0.9850 1.58 0.244 0.171 -0.0904 0.579
0.3 0.9850 2.00 0.244 0.171 -0.0904 0.579
0.4 0.9830 2.51 0.244 0.171 -0.0906 0.579
0.5 0.9820 3.16 0.244 0.171 -0.0909 0.580
0.6 0.9820 3.98 0.244 0.171 -0.0909 0.580
0.7 0.9820 5.01 0.244 0.171 -0.0909 0.580
0.8 0.9770 6.31 0.244 0.172 -0.0919 0.581
0.9 0.9730 7.94 0.244 0.172 -0.0929 0.582
1.0 0.9730 10.00 0.244 0.172 -0.0929 0.582
1.1 0.9660 12.60 0.244 0.173 -0.0942 0.583
1.2 0.9660 15.80 0.244 0.173 -0.0942 0.583
1.3 0.9660 20.00 0.244 0.173 -0.0942 0.583
1.4 0.9660 25.10 0.244 0.173 -0.0942 0.583
1.5 0.9620 31.60 0.244 0.173 -0.0947 0.583
1.6 0.9510 39.80 0.244 0.171 -0.0910 0.580
1.7 0.9470 50.10 0.244 0.172 -0.0919 0.581
1.8 0.9450 63.10 0.244 0.172 -0.0923 0.581
1.9 0.9360 79.40 0.244 0.173 -0.0947 0.583
2.0 0.9290 100.00 0.244 0.174 -0.0960 0.585
2.1 0.9100 126.00 0.244 0.173 -0.0940 0.583
2.2 0.8860 158.00 0.244 0.176 -0.1010 0.589
2.3 0.8750 200.00 0.244 0.177 -0.1030 0.592
2.4 0.8610 251.00 0.244 0.175 -0.0993 0.588
2.5 0.8310 316.00 0.244 0.177 -0.1030 0.591
2.6 0.8040 398.00 0.244 0.179 -0.1070 0.596
2.7 0.7140 501.00 0.244 0.190 -0.1270 0.616
2.8 0.6780 631.00 0.244 0.193 -0.1330 0.622
2.9 0.6350 794.00 0.244 0.197 -0.1410 0.630
3.0 0.5780 1000.00 0.244 0.207 -0.1610 0.650
3.1 0.5070 1260.00 0.244 0.220 -0.1870 0.676
3.2 0.4410 1580.00 0.244 0.240 -0.2260 0.714
3.3 0.3480 2000.00 0.244 0.262 -0.2700 0.758
3.4 0.3030 2510.00 0.244 0.289 -0.3210 0.810
3.5 0.2460 3160.00 0.244 0.336 -0.4150 0.904
3.6 0.1980 3980.00 0.244 0.383 -0.5060 0.994
3.7 0.1560 5010.00 0.244 0.475 -0.6870 1.180
3.8 0.1080 6310.00 0.244 0.571 -0.8750 1.360
3.9 0.0747 7940.00 0.244 0.750 -1.2300 1.710
4.0 0.0655 10000.00 0.244 0.863 -1.4500 1.940
4.1 0.0609 12600.00 0.244 0.742 -1.2100 1.700
4.2 0.0451 15800.00 0.244 1.020 -1.7600 2.250

IgG3_gp70V1V2A

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00611 0.000929 0.004280 0.00793
0.1 0.9280 1.26 0.00611 0.001090 0.003960 0.00825
0.2 0.9200 1.58 0.00611 0.001100 0.003950 0.00826
0.3 0.9180 2.00 0.00611 0.001100 0.003940 0.00827
0.4 0.9120 2.51 0.00607 0.001090 0.003920 0.00821
0.5 0.9100 3.16 0.00607 0.001100 0.003920 0.00821
0.6 0.8940 3.98 0.00602 0.001090 0.003880 0.00816
0.7 0.8810 5.01 0.00602 0.001110 0.003850 0.00819
0.8 0.8640 6.31 0.00598 0.001110 0.003810 0.00815
0.9 0.8450 7.94 0.00595 0.001120 0.003760 0.00814
1.0 0.8230 10.00 0.00548 0.001070 0.003380 0.00758
1.1 0.7770 12.60 0.00548 0.001120 0.003280 0.00768
1.2 0.7290 15.80 0.00533 0.001100 0.003170 0.00749
1.3 0.6790 20.00 0.00533 0.001140 0.003100 0.00756
1.4 0.5720 25.10 0.00533 0.001310 0.002770 0.00789
1.5 0.5260 31.60 0.00533 0.001340 0.002700 0.00796
1.6 0.4750 39.80 0.00533 0.001440 0.002510 0.00815
1.7 0.3890 50.10 0.00533 0.001610 0.002170 0.00849
1.8 0.3320 63.10 0.00533 0.001360 0.002660 0.00799
1.9 0.2540 79.40 0.00533 0.001760 0.001890 0.00877
2.0 0.2230 100.00 0.00533 0.002150 0.001120 0.00954
2.1 0.1870 126.00 0.00533 0.002260 0.000908 0.00975
2.2 0.1270 158.00 0.00533 0.003340 -0.001210 0.01190
2.3 0.1160 200.00 0.00533 0.003320 -0.001180 0.01180
2.4 0.1020 251.00 0.00533 0.003570 -0.001660 0.01230
2.5 0.0569 316.00 0.00533 0.008910 -0.012100 0.02280
2.6 0.0467 398.00 0.00533 0.026800 -0.047200 0.05780

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00595 0.000929 0.003920 0.00797
0.1 1.26 0.9280 0.00613 0.001090 0.003990 0.00827
0.2 1.58 0.9200 0.00617 0.001100 0.004010 0.00833
0.3 2.00 0.9180 0.00618 0.001100 0.004020 0.00834
0.4 2.51 0.9120 0.00606 0.001090 0.003920 0.00820
0.5 3.16 0.9100 0.00607 0.001100 0.003920 0.00822
0.6 3.98 0.8940 0.00598 0.001090 0.003840 0.00813
0.7 5.01 0.8810 0.00605 0.001110 0.003880 0.00823
0.8 6.31 0.8640 0.00598 0.001110 0.003810 0.00815
0.9 7.94 0.8450 0.00595 0.001120 0.003760 0.00814
1.0 10.00 0.8230 0.00541 0.001070 0.003310 0.00751
1.1 12.60 0.7770 0.00555 0.001120 0.003360 0.00775
1.2 15.80 0.7290 0.00511 0.001100 0.002950 0.00726
1.3 20.00 0.6790 0.00508 0.001140 0.002850 0.00731
1.4 25.10 0.5720 0.00543 0.001310 0.002870 0.00799
1.5 31.60 0.5260 0.00531 0.001340 0.002680 0.00793
1.6 39.80 0.4750 0.00553 0.001440 0.002710 0.00835
1.7 50.10 0.3890 0.00562 0.001610 0.002470 0.00878
1.8 63.10 0.3320 0.00358 0.001360 0.000915 0.00625
1.9 79.40 0.2540 0.00398 0.001760 0.000537 0.00742
2.0 100.00 0.2230 0.00481 0.002150 0.000599 0.00901
2.1 126.00 0.1870 0.00466 0.002260 0.000240 0.00908
2.2 158.00 0.1270 0.00640 0.003340 -0.000144 0.01290
2.3 200.00 0.1160 0.00576 0.003320 -0.000750 0.01230
2.4 251.00 0.1020 0.00539 0.003570 -0.001600 0.01240
2.5 316.00 0.0569 0.01170 0.008910 -0.005820 0.02910
2.6 398.00 0.0467 0.02270 0.026800 -0.029800 0.07520

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.207 0.166 -0.1180 0.533
0.1 0.9280 1.26 0.207 0.182 -0.1500 0.564
0.2 0.9200 1.58 0.207 0.183 -0.1520 0.566
0.3 0.9180 2.00 0.207 0.183 -0.1520 0.566
0.4 0.9120 2.51 0.212 0.182 -0.1440 0.569
0.5 0.9100 3.16 0.212 0.182 -0.1440 0.569
0.6 0.8940 3.98 0.218 0.181 -0.1370 0.574
0.7 0.8810 5.01 0.218 0.183 -0.1400 0.576
0.8 0.8640 6.31 0.224 0.182 -0.1340 0.581
0.9 0.8450 7.94 0.227 0.183 -0.1310 0.586
1.0 0.8230 10.00 0.288 0.173 -0.0503 0.627
1.1 0.7770 12.60 0.288 0.178 -0.0604 0.637
1.2 0.7290 15.80 0.308 0.174 -0.0336 0.650
1.3 0.6790 20.00 0.308 0.178 -0.0414 0.657
1.4 0.5720 25.10 0.308 0.197 -0.0778 0.694
1.5 0.5260 31.60 0.308 0.201 -0.0852 0.701
1.6 0.4750 39.80 0.308 0.212 -0.1070 0.723
1.7 0.3890 50.10 0.308 0.232 -0.1460 0.762
1.8 0.3320 63.10 0.308 0.203 -0.0895 0.705
1.9 0.2540 79.40 0.308 0.249 -0.1800 0.796
2.0 0.2230 100.00 0.308 0.296 -0.2720 0.888
2.1 0.1870 126.00 0.308 0.309 -0.2990 0.915
2.2 0.1270 158.00 0.308 0.445 -0.5640 1.180
2.3 0.1160 200.00 0.308 0.442 -0.5590 1.180
2.4 0.1020 251.00 0.308 0.474 -0.6210 1.240
2.5 0.0569 316.00 0.308 1.160 -1.9700 2.580
2.6 0.0467 398.00 0.308 3.480 -6.5100 7.130

IgG3_gp70V1V2AP

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00607 0.000929 0.004250 0.00789
0.1 0.9290 1.26 0.00607 0.001080 0.003960 0.00818
0.2 0.9290 1.58 0.00607 0.001080 0.003960 0.00818
0.3 0.9120 2.00 0.00607 0.001100 0.003920 0.00822
0.4 0.9010 2.51 0.00607 0.001100 0.003910 0.00823
0.5 0.8970 3.16 0.00590 0.001070 0.003790 0.00800
0.6 0.8710 3.98 0.00590 0.001100 0.003740 0.00805
0.7 0.8450 5.01 0.00590 0.001100 0.003750 0.00805
0.8 0.8290 6.31 0.00590 0.001120 0.003690 0.00810
0.9 0.7810 7.94 0.00590 0.001160 0.003630 0.00816
1.0 0.7400 10.00 0.00590 0.001150 0.003640 0.00816
1.1 0.7020 12.60 0.00590 0.001230 0.003480 0.00831
1.2 0.6360 15.80 0.00590 0.001340 0.003260 0.00853
1.3 0.5770 20.00 0.00590 0.001320 0.003300 0.00849
1.4 0.4680 25.10 0.00590 0.001530 0.002900 0.00890
1.5 0.4130 31.60 0.00544 0.001510 0.002490 0.00839
1.6 0.3350 39.80 0.00530 0.001640 0.002090 0.00851
1.7 0.2870 50.10 0.00530 0.001790 0.001790 0.00882
1.8 0.2140 63.10 0.00530 0.002290 0.000809 0.00979
1.9 0.1690 79.40 0.00530 0.003040 -0.000663 0.01130
2.0 0.1560 100.00 0.00530 0.003180 -0.000938 0.01150
2.1 0.1420 126.00 0.00530 0.003640 -0.001830 0.01240
2.2 0.1190 158.00 0.00530 0.004150 -0.002830 0.01340
2.3 0.0961 200.00 0.00530 0.005210 -0.004900 0.01550
2.4 0.0758 251.00 0.00530 0.006550 -0.007540 0.01810
2.5 0.0646 316.00 0.00530 0.004890 -0.004290 0.01490
2.6 0.0556 398.00 0.00530 0.006500 -0.007450 0.01810
2.7 0.0455 501.00 0.00530 0.006230 -0.006900 0.01750
2.8 0.0353 631.00 0.00530 0.009160 -0.012700 0.02330
2.9 0.0252 794.00 0.00530 0.018100 -0.030100 0.04070

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00595 0.000929 0.003920 0.00797
0.1 1.26 0.9290 0.00606 0.001080 0.003950 0.00817
0.2 1.58 0.9290 0.00606 0.001080 0.003950 0.00817
0.3 2.00 0.9120 0.00617 0.001100 0.004020 0.00833
0.4 2.51 0.9010 0.00612 0.001100 0.003950 0.00828
0.5 3.16 0.8970 0.00581 0.001070 0.003710 0.00791
0.6 3.98 0.8710 0.00594 0.001100 0.003790 0.00810
0.7 5.01 0.8450 0.00578 0.001100 0.003630 0.00793
0.8 6.31 0.8290 0.00591 0.001120 0.003700 0.00811
0.9 7.94 0.7810 0.00587 0.001160 0.003600 0.00813
1.0 10.00 0.7400 0.00560 0.001150 0.003340 0.00786
1.1 12.60 0.7020 0.00594 0.001230 0.003530 0.00835
1.2 15.80 0.6360 0.00634 0.001340 0.003710 0.00898
1.3 20.00 0.5770 0.00572 0.001320 0.003120 0.00831
1.4 25.10 0.4680 0.00611 0.001530 0.003110 0.00911
1.5 31.60 0.4130 0.00544 0.001510 0.002490 0.00839
1.6 39.80 0.3350 0.00515 0.001640 0.001940 0.00836
1.7 50.10 0.2870 0.00539 0.001790 0.001870 0.00890
1.8 63.10 0.2140 0.00616 0.002290 0.001670 0.01070
1.9 79.40 0.1690 0.00783 0.003040 0.001870 0.01380
2.0 100.00 0.1560 0.00718 0.003180 0.000937 0.01340
2.1 126.00 0.1420 0.00759 0.003640 0.000459 0.01470
2.2 158.00 0.1190 0.00735 0.004150 -0.000776 0.01550
2.3 200.00 0.0961 0.00877 0.005210 -0.001430 0.01900
2.4 251.00 0.0758 0.01080 0.006550 -0.002000 0.02370
2.5 316.00 0.0646 0.00747 0.004890 -0.002130 0.01710
2.6 398.00 0.0556 0.00727 0.006500 -0.005480 0.02000
2.7 501.00 0.0455 0.01210 0.006230 -0.000140 0.02430
2.8 631.00 0.0353 0.01700 0.009160 -0.000976 0.03490
2.9 794.00 0.0252 0.03020 0.018100 -0.005190 0.06560

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.212 0.166 -0.113 0.537
0.1 0.9290 1.26 0.212 0.180 -0.141 0.565
0.2 0.9290 1.58 0.212 0.180 -0.141 0.565
0.3 0.9120 2.00 0.212 0.182 -0.146 0.569
0.4 0.9010 2.51 0.212 0.183 -0.146 0.570
0.5 0.8970 3.16 0.234 0.178 -0.114 0.583
0.6 0.8710 3.98 0.234 0.180 -0.119 0.588
0.7 0.8450 5.01 0.234 0.180 -0.119 0.588
0.8 0.8290 6.31 0.234 0.183 -0.124 0.593
0.9 0.7810 7.94 0.234 0.186 -0.131 0.599
1.0 0.7400 10.00 0.234 0.186 -0.130 0.599
1.1 0.7020 12.60 0.234 0.194 -0.146 0.615
1.2 0.6360 15.80 0.234 0.207 -0.171 0.639
1.3 0.5770 20.00 0.234 0.204 -0.166 0.635
1.4 0.4680 25.10 0.234 0.227 -0.211 0.680
1.5 0.4130 31.60 0.294 0.221 -0.138 0.726
1.6 0.3350 39.80 0.312 0.235 -0.148 0.771
1.7 0.2870 50.10 0.312 0.253 -0.185 0.808
1.8 0.2140 63.10 0.312 0.314 -0.303 0.927
1.9 0.1690 79.40 0.312 0.407 -0.487 1.110
2.0 0.1560 100.00 0.312 0.425 -0.522 1.140
2.1 0.1420 126.00 0.312 0.483 -0.634 1.260
2.2 0.1190 158.00 0.312 0.548 -0.762 1.380
2.3 0.0961 200.00 0.312 0.683 -1.030 1.650
2.4 0.0758 251.00 0.312 0.857 -1.370 1.990
2.5 0.0646 316.00 0.312 0.643 -0.949 1.570
2.6 0.0556 398.00 0.312 0.850 -1.360 1.980
2.7 0.0455 501.00 0.312 0.815 -1.290 1.910
2.8 0.0353 631.00 0.312 1.190 -2.030 2.650
2.9 0.0252 794.00 0.312 2.350 -4.290 4.910

IgG3_gp70V1V2C

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00595 0.000929 0.004130 0.00777
0.1 0.9280 1.26 0.00529 0.000996 0.003330 0.00724
0.2 0.9260 1.58 0.00518 0.000980 0.003260 0.00711
0.3 0.9210 2.00 0.00518 0.000984 0.003260 0.00711
0.4 0.9170 2.51 0.00518 0.000992 0.003240 0.00713
0.5 0.9100 3.16 0.00518 0.001010 0.003210 0.00715
0.6 0.8940 3.98 0.00510 0.000991 0.003160 0.00705
0.7 0.8780 5.01 0.00510 0.001010 0.003130 0.00707
0.8 0.8540 6.31 0.00510 0.001010 0.003120 0.00709
0.9 0.8320 7.94 0.00510 0.001020 0.003110 0.00710
1.0 0.8040 10.00 0.00510 0.001040 0.003070 0.00714
1.1 0.7570 12.60 0.00510 0.001090 0.002970 0.00724
1.2 0.7220 15.80 0.00510 0.001100 0.002960 0.00725
1.3 0.6570 20.00 0.00510 0.001210 0.002730 0.00748
1.4 0.6130 25.10 0.00503 0.001140 0.002790 0.00726
1.5 0.5470 31.60 0.00503 0.001290 0.002500 0.00755
1.6 0.4920 39.80 0.00503 0.001330 0.002410 0.00764
1.7 0.4430 50.10 0.00503 0.001380 0.002320 0.00774
1.8 0.3570 63.10 0.00503 0.001640 0.001810 0.00824
1.9 0.3040 79.40 0.00503 0.001540 0.002010 0.00804
2.0 0.2730 100.00 0.00503 0.001530 0.002030 0.00803
2.1 0.2150 126.00 0.00503 0.001880 0.001350 0.00871
2.2 0.1780 158.00 0.00503 0.002290 0.000544 0.00951
2.3 0.1270 200.00 0.00503 0.003730 -0.002290 0.01230
2.4 0.0928 251.00 0.00503 0.004480 -0.003750 0.01380
2.5 0.0546 316.00 0.00503 0.009350 -0.013300 0.02340

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00595 0.000929 0.003920 0.00797
0.1 1.26 0.9280 0.00529 0.000996 0.003330 0.00724
0.2 1.58 0.9260 0.00514 0.000980 0.003210 0.00706
0.3 2.00 0.9210 0.00515 0.000984 0.003220 0.00708
0.4 2.51 0.9170 0.00519 0.000992 0.003250 0.00714
0.5 3.16 0.9100 0.00526 0.001010 0.003290 0.00723
0.6 3.98 0.8940 0.00504 0.000991 0.003090 0.00698
0.7 5.01 0.8780 0.00510 0.001010 0.003130 0.00707
0.8 6.31 0.8540 0.00506 0.001010 0.003080 0.00704
0.9 7.94 0.8320 0.00501 0.001020 0.003010 0.00701
1.0 10.00 0.8040 0.00502 0.001040 0.002990 0.00706
1.1 12.60 0.7570 0.00515 0.001090 0.003020 0.00728
1.2 15.80 0.7220 0.00500 0.001100 0.002850 0.00714
1.3 20.00 0.6570 0.00549 0.001210 0.003110 0.00786
1.4 25.10 0.6130 0.00466 0.001140 0.002420 0.00689
1.5 31.60 0.5470 0.00518 0.001290 0.002650 0.00770
1.6 39.80 0.4920 0.00508 0.001330 0.002470 0.00770
1.7 50.10 0.4430 0.00496 0.001380 0.002250 0.00767
1.8 63.10 0.3570 0.00531 0.001640 0.002100 0.00853
1.9 79.40 0.3040 0.00419 0.001540 0.001180 0.00720
2.0 100.00 0.2730 0.00372 0.001530 0.000721 0.00672
2.1 126.00 0.2150 0.00425 0.001880 0.000565 0.00793
2.2 158.00 0.1780 0.00510 0.002290 0.000622 0.00958
2.3 200.00 0.1270 0.00798 0.003730 0.000665 0.01530
2.4 251.00 0.0928 0.00754 0.004480 -0.001240 0.01630
2.5 316.00 0.0546 0.01220 0.009350 -0.006170 0.03050

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.228 0.164 -0.09420 0.549
0.1 0.9280 1.26 0.314 0.163 -0.00556 0.633
0.2 0.9260 1.58 0.327 0.160 0.01300 0.641
0.3 0.9210 2.00 0.327 0.160 0.01230 0.641
0.4 0.9170 2.51 0.327 0.161 0.01070 0.643
0.5 0.9100 3.16 0.327 0.163 0.00802 0.646
0.6 0.8940 3.98 0.337 0.160 0.02310 0.651
0.7 0.8780 5.01 0.337 0.162 0.02010 0.654
0.8 0.8540 6.31 0.337 0.163 0.01860 0.656
0.9 0.8320 7.94 0.337 0.163 0.01720 0.657
1.0 0.8040 10.00 0.337 0.165 0.01290 0.662
1.1 0.7570 12.60 0.337 0.171 0.00278 0.672
1.2 0.7220 15.80 0.337 0.171 0.00135 0.673
1.3 0.6570 20.00 0.337 0.184 -0.02390 0.698
1.4 0.6130 25.10 0.347 0.176 0.00315 0.692
1.5 0.5470 31.60 0.347 0.192 -0.02850 0.723
1.6 0.4920 39.80 0.347 0.197 -0.03900 0.734
1.7 0.4430 50.10 0.347 0.203 -0.05000 0.745
1.8 0.3570 63.10 0.347 0.233 -0.10900 0.804
1.9 0.3040 79.40 0.347 0.221 -0.08490 0.780
2.0 0.2730 100.00 0.347 0.220 -0.08360 0.778
2.1 0.2150 126.00 0.347 0.261 -0.16500 0.860
2.2 0.1780 158.00 0.347 0.311 -0.26300 0.958
2.3 0.1270 200.00 0.347 0.493 -0.62000 1.310
2.4 0.0928 251.00 0.347 0.589 -0.80700 1.500
2.5 0.0546 316.00 0.347 1.220 -2.04000 2.730

IgG3_gp70.V1V2CaseA2

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00595 0.000929 0.004130 0.00777
0.1 0.9400 1.26 0.00571 0.001040 0.003680 0.00775
0.2 0.9400 1.58 0.00571 0.001040 0.003680 0.00775
0.3 0.9350 2.00 0.00558 0.001030 0.003570 0.00759
0.4 0.9220 2.51 0.00555 0.001020 0.003550 0.00756
0.5 0.9080 3.16 0.00555 0.001040 0.003520 0.00759
0.6 0.8880 3.98 0.00555 0.001050 0.003500 0.00760
0.7 0.8690 5.01 0.00555 0.001070 0.003460 0.00765
0.8 0.8530 6.31 0.00549 0.001050 0.003420 0.00755
0.9 0.8230 7.94 0.00549 0.001090 0.003350 0.00762
1.0 0.7850 10.00 0.00545 0.001100 0.003300 0.00761
1.1 0.7310 12.60 0.00468 0.001010 0.002690 0.00666
1.2 0.6730 15.80 0.00468 0.001080 0.002570 0.00679
1.3 0.6550 20.00 0.00468 0.001110 0.002510 0.00685
1.4 0.5890 25.10 0.00468 0.001210 0.002300 0.00705
1.5 0.4950 31.60 0.00468 0.001280 0.002170 0.00719
1.6 0.4320 39.80 0.00468 0.001400 0.001930 0.00742
1.7 0.3540 50.10 0.00403 0.001400 0.001280 0.00678
1.8 0.3130 63.10 0.00403 0.001420 0.001250 0.00681
1.9 0.2540 79.40 0.00403 0.001580 0.000937 0.00712
2.0 0.2240 100.00 0.00403 0.001820 0.000460 0.00759
2.1 0.1580 126.00 0.00403 0.002630 -0.001140 0.00919
2.2 0.1150 158.00 0.00403 0.004010 -0.003840 0.01190
2.3 0.0712 200.00 0.00403 0.006370 -0.008460 0.01650
2.4 0.0578 251.00 0.00403 0.011200 -0.017900 0.02590

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00595 0.000929 0.003920 0.00797
0.1 1.26 0.9400 0.00571 0.001040 0.003680 0.00775
0.2 1.58 0.9400 0.00571 0.001040 0.003680 0.00775
0.3 2.00 0.9350 0.00558 0.001030 0.003570 0.00759
0.4 2.51 0.9220 0.00548 0.001020 0.003480 0.00749
0.5 3.16 0.9080 0.00556 0.001040 0.003530 0.00759
0.6 3.98 0.8880 0.00553 0.001050 0.003480 0.00758
0.7 5.01 0.8690 0.00564 0.001070 0.003540 0.00774
0.8 6.31 0.8530 0.00541 0.001050 0.003340 0.00747
0.9 7.94 0.8230 0.00557 0.001090 0.003430 0.00771
1.0 10.00 0.7850 0.00545 0.001100 0.003300 0.00761
1.1 12.60 0.7310 0.00446 0.001010 0.002470 0.00645
1.2 15.80 0.6730 0.00453 0.001080 0.002420 0.00664
1.3 20.00 0.6550 0.00465 0.001110 0.002480 0.00682
1.4 25.10 0.5890 0.00494 0.001210 0.002560 0.00732
1.5 31.60 0.4950 0.00464 0.001280 0.002130 0.00715
1.6 39.80 0.4320 0.00491 0.001400 0.002160 0.00765
1.7 50.10 0.3540 0.00400 0.001400 0.001250 0.00675
1.8 63.10 0.3130 0.00386 0.001420 0.001080 0.00664
1.9 79.40 0.2540 0.00385 0.001580 0.000762 0.00694
2.0 100.00 0.2240 0.00436 0.001820 0.000797 0.00793
2.1 126.00 0.1580 0.00574 0.002630 0.000580 0.01090
2.2 158.00 0.1150 0.00837 0.004010 0.000499 0.01620
2.3 200.00 0.0712 0.00974 0.006370 -0.002740 0.02220
2.4 251.00 0.0578 0.01450 0.011200 -0.007390 0.03640

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.228 0.164 -0.09420 0.549
0.1 0.9400 1.26 0.258 0.172 -0.07900 0.596
0.2 0.9400 1.58 0.258 0.172 -0.07900 0.596
0.3 0.9350 2.00 0.276 0.169 -0.05600 0.608
0.4 0.9220 2.51 0.279 0.169 -0.05150 0.609
0.5 0.9080 3.16 0.279 0.170 -0.05460 0.612
0.6 0.8880 3.98 0.279 0.171 -0.05650 0.614
0.7 0.8690 5.01 0.279 0.174 -0.06130 0.619
0.8 0.8530 6.31 0.287 0.171 -0.04790 0.623
0.9 0.8230 7.94 0.287 0.175 -0.05540 0.630
1.0 0.7850 10.00 0.292 0.176 -0.05250 0.636
1.1 0.7310 12.60 0.393 0.158 0.08290 0.703
1.2 0.6730 15.80 0.393 0.165 0.06960 0.716
1.3 0.6550 20.00 0.393 0.168 0.06280 0.723
1.4 0.5890 25.10 0.393 0.180 0.03960 0.746
1.5 0.4950 31.60 0.393 0.188 0.02440 0.761
1.6 0.4320 39.80 0.393 0.202 -0.00308 0.789
1.7 0.3540 50.10 0.477 0.197 0.09080 0.863
1.8 0.3130 63.10 0.477 0.199 0.08690 0.867
1.9 0.2540 79.40 0.477 0.218 0.04940 0.905
2.0 0.2240 100.00 0.477 0.248 -0.00922 0.963
2.1 0.1580 126.00 0.477 0.350 -0.21000 1.160
2.2 0.1150 158.00 0.477 0.527 -0.55500 1.510
2.3 0.0712 200.00 0.477 0.830 -1.15000 2.100
2.4 0.0578 251.00 0.477 1.450 -2.37000 3.330

IgG3_gp70BCaseA2V1V2169K

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00595 0.000929 0.004130 0.00777
0.1 0.9690 1.26 0.00544 0.000984 0.003510 0.00737
0.2 0.9690 1.58 0.00544 0.000984 0.003510 0.00737
0.3 0.9690 2.00 0.00544 0.000984 0.003510 0.00737
0.4 0.9690 2.51 0.00544 0.000984 0.003510 0.00737
0.5 0.9680 3.16 0.00544 0.000985 0.003510 0.00737
0.6 0.9630 3.98 0.00544 0.000989 0.003500 0.00738
0.7 0.9570 5.01 0.00544 0.000995 0.003490 0.00739
0.8 0.9320 6.31 0.00544 0.001020 0.003430 0.00745
0.9 0.9090 7.94 0.00544 0.001030 0.003410 0.00747
1.0 0.9000 10.00 0.00544 0.001040 0.003390 0.00748
1.1 0.8910 12.60 0.00531 0.001020 0.003320 0.00731
1.2 0.8790 15.80 0.00526 0.001010 0.003280 0.00725
1.3 0.8530 20.00 0.00526 0.001020 0.003260 0.00727
1.4 0.8270 25.10 0.00526 0.001060 0.003190 0.00734
1.5 0.7790 31.60 0.00526 0.001090 0.003130 0.00740
1.6 0.7450 39.80 0.00497 0.001070 0.002870 0.00707
1.7 0.7010 50.10 0.00488 0.001080 0.002760 0.00701
1.8 0.6550 63.10 0.00488 0.001130 0.002670 0.00710
1.9 0.6150 79.40 0.00488 0.001160 0.002610 0.00715
2.0 0.5360 100.00 0.00488 0.001260 0.002400 0.00736
2.1 0.4630 126.00 0.00488 0.001400 0.002150 0.00762
2.2 0.3790 158.00 0.00488 0.001520 0.001910 0.00785
2.3 0.3270 200.00 0.00439 0.001510 0.001430 0.00735
2.4 0.2760 251.00 0.00439 0.001790 0.000871 0.00791
2.5 0.2130 316.00 0.00439 0.002160 0.000153 0.00862
2.6 0.1640 398.00 0.00439 0.002530 -0.000568 0.00935
2.7 0.1200 501.00 0.00439 0.003680 -0.002820 0.01160
2.8 0.1060 631.00 0.00439 0.002920 -0.001330 0.01010
2.9 0.0781 794.00 0.00439 0.004290 -0.004020 0.01280
3.0 0.0658 1000.00 0.00439 0.003860 -0.003180 0.01200
3.1 0.0512 1260.00 0.00439 0.005710 -0.006800 0.01560

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00595 0.000929 0.003920 0.00797
0.1 1.26 0.9690 0.00537 0.000984 0.003440 0.00730
0.2 1.58 0.9690 0.00537 0.000984 0.003440 0.00730
0.3 2.00 0.9690 0.00537 0.000984 0.003440 0.00730
0.4 2.51 0.9690 0.00537 0.000984 0.003440 0.00730
0.5 3.16 0.9680 0.00538 0.000985 0.003440 0.00731
0.6 3.98 0.9630 0.00540 0.000989 0.003460 0.00733
0.7 5.01 0.9570 0.00542 0.000995 0.003470 0.00737
0.8 6.31 0.9320 0.00558 0.001020 0.003570 0.00758
0.9 7.94 0.9090 0.00555 0.001030 0.003520 0.00758
1.0 10.00 0.9000 0.00560 0.001040 0.003550 0.00764
1.1 12.60 0.8910 0.00531 0.001020 0.003320 0.00731
1.2 15.80 0.8790 0.00521 0.001010 0.003230 0.00719
1.3 20.00 0.8530 0.00519 0.001020 0.003180 0.00720
1.4 25.10 0.8270 0.00535 0.001060 0.003280 0.00743
1.5 31.60 0.7790 0.00531 0.001090 0.003170 0.00744
1.6 39.80 0.7450 0.00497 0.001070 0.002870 0.00707
1.7 50.10 0.7010 0.00474 0.001080 0.002610 0.00686
1.8 63.10 0.6550 0.00484 0.001130 0.002620 0.00705
1.9 79.40 0.6150 0.00474 0.001160 0.002460 0.00701
2.0 100.00 0.5360 0.00488 0.001260 0.002410 0.00736
2.1 126.00 0.4630 0.00520 0.001400 0.002470 0.00794
2.2 158.00 0.3790 0.00496 0.001520 0.001990 0.00794
2.3 200.00 0.3270 0.00437 0.001510 0.001420 0.00733
2.4 251.00 0.2760 0.00481 0.001790 0.001290 0.00832
2.5 316.00 0.2130 0.00539 0.002160 0.001150 0.00962
2.6 398.00 0.1640 0.00597 0.002530 0.001010 0.01090
2.7 501.00 0.1200 0.00827 0.003680 0.001060 0.01550
2.8 631.00 0.1060 0.00518 0.002920 -0.000537 0.01090
2.9 794.00 0.0781 0.00653 0.004290 -0.001870 0.01490
3.0 1000.00 0.0658 0.00518 0.003860 -0.002380 0.01280
3.1 1260.00 0.0512 0.00655 0.005710 -0.004640 0.01770

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.228 0.164 -0.09420 0.549
0.1 0.9690 1.26 0.294 0.163 -0.02620 0.614
0.2 0.9690 1.58 0.294 0.163 -0.02620 0.614
0.3 0.9690 2.00 0.294 0.163 -0.02620 0.614
0.4 0.9690 2.51 0.294 0.163 -0.02620 0.614
0.5 0.9680 3.16 0.294 0.164 -0.02660 0.614
0.6 0.9630 3.98 0.294 0.164 -0.02740 0.615
0.7 0.9570 5.01 0.294 0.164 -0.02840 0.616
0.8 0.9320 6.31 0.294 0.168 -0.03460 0.622
0.9 0.9090 7.94 0.294 0.169 -0.03650 0.624
1.0 0.9000 10.00 0.294 0.170 -0.03840 0.626
1.1 0.8910 12.60 0.310 0.165 -0.01390 0.634
1.2 0.8790 15.80 0.316 0.164 -0.00540 0.638
1.3 0.8530 20.00 0.316 0.166 -0.00799 0.641
1.4 0.8270 25.10 0.316 0.169 -0.01510 0.648
1.5 0.7790 31.60 0.316 0.172 -0.02120 0.654
1.6 0.7450 39.80 0.355 0.167 0.02660 0.683
1.7 0.7010 50.10 0.366 0.168 0.03710 0.695
1.8 0.6550 63.10 0.366 0.173 0.02720 0.705
1.9 0.6150 79.40 0.366 0.176 0.02080 0.711
2.0 0.5360 100.00 0.366 0.188 -0.00210 0.734
2.1 0.4630 126.00 0.366 0.203 -0.03180 0.764
2.2 0.3790 158.00 0.366 0.217 -0.05930 0.791
2.3 0.3270 200.00 0.430 0.213 0.01360 0.847
2.4 0.2760 251.00 0.430 0.247 -0.05420 0.914
2.5 0.2130 316.00 0.430 0.292 -0.14300 1.000
2.6 0.1640 398.00 0.430 0.339 -0.23300 1.090
2.7 0.1200 501.00 0.430 0.485 -0.52000 1.380
2.8 0.1060 631.00 0.430 0.387 -0.32900 1.190
2.9 0.0781 794.00 0.430 0.563 -0.67300 1.530
3.0 0.0658 1000.00 0.430 0.508 -0.56600 1.430
3.1 0.0512 1260.00 0.430 0.746 -1.03000 1.890

IgG3_gp70BCaseA2V1V2mut3

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00595 0.000929 0.004130 0.00777
0.1 0.9830 1.26 0.00584 0.001010 0.003850 0.00783
0.2 0.9830 1.58 0.00584 0.001010 0.003850 0.00783
0.3 0.9830 2.00 0.00584 0.001010 0.003850 0.00783
0.4 0.9830 2.51 0.00584 0.001010 0.003850 0.00783
0.5 0.9820 3.16 0.00584 0.001020 0.003850 0.00783
0.6 0.9820 3.98 0.00584 0.001020 0.003850 0.00783
0.7 0.9770 5.01 0.00584 0.001020 0.003840 0.00784
0.8 0.9770 6.31 0.00584 0.001020 0.003840 0.00784
0.9 0.9730 7.94 0.00584 0.001030 0.003830 0.00785
1.0 0.9730 10.00 0.00584 0.001030 0.003830 0.00785
1.1 0.9660 12.60 0.00584 0.001030 0.003820 0.00786
1.2 0.9660 15.80 0.00584 0.001030 0.003820 0.00786
1.3 0.9660 20.00 0.00584 0.001030 0.003820 0.00786
1.4 0.9560 25.10 0.00584 0.001040 0.003800 0.00788
1.5 0.9510 31.60 0.00584 0.001050 0.003790 0.00789
1.6 0.9470 39.80 0.00584 0.001020 0.003840 0.00784
1.7 0.9470 50.10 0.00584 0.001020 0.003840 0.00784
1.8 0.9360 63.10 0.00584 0.001030 0.003810 0.00787
1.9 0.9240 79.40 0.00584 0.001030 0.003820 0.00786
2.0 0.9100 100.00 0.00584 0.001030 0.003830 0.00786
2.1 0.8860 126.00 0.00584 0.001060 0.003760 0.00792
2.2 0.8660 158.00 0.00584 0.001070 0.003750 0.00794
2.3 0.8400 200.00 0.00584 0.001080 0.003720 0.00796
2.4 0.8310 251.00 0.00584 0.001070 0.003740 0.00795
2.5 0.8130 316.00 0.00584 0.001060 0.003770 0.00792
2.6 0.7360 398.00 0.00584 0.001090 0.003710 0.00797
2.7 0.6780 501.00 0.00584 0.001190 0.003510 0.00817
2.8 0.6200 631.00 0.00584 0.001290 0.003320 0.00836
2.9 0.5480 794.00 0.00584 0.001470 0.002970 0.00872
3.0 0.4750 1000.00 0.00584 0.001580 0.002740 0.00894
3.1 0.4220 1260.00 0.00584 0.001710 0.002500 0.00918
3.2 0.3250 1580.00 0.00584 0.002010 0.001910 0.00977
3.3 0.2650 2000.00 0.00584 0.002200 0.001530 0.01020
3.4 0.2370 2510.00 0.00584 0.002530 0.000891 0.01080
3.5 0.1710 3160.00 0.00584 0.003350 -0.000720 0.01240
3.6 0.1350 3980.00 0.00584 0.003950 -0.001910 0.01360
3.7 0.0950 5010.00 0.00584 0.004830 -0.003620 0.01530
3.8 0.0745 6310.00 0.00584 0.005310 -0.004560 0.01620
3.9 0.0654 7940.00 0.00584 0.005130 -0.004210 0.01590
4.0 0.0451 10000.00 0.00584 0.007840 -0.009520 0.02120
4.1 0.0451 12600.00 0.00584 0.007840 -0.009520 0.02120

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00595 0.000929 0.003920 0.00797
0.1 1.26 0.9830 0.00573 0.001010 0.003740 0.00771
0.2 1.58 0.9830 0.00573 0.001010 0.003740 0.00771
0.3 2.00 0.9830 0.00573 0.001010 0.003740 0.00771
0.4 2.51 0.9830 0.00573 0.001010 0.003740 0.00771
0.5 3.16 0.9820 0.00573 0.001020 0.003740 0.00772
0.6 3.98 0.9820 0.00573 0.001020 0.003740 0.00772
0.7 5.01 0.9770 0.00576 0.001020 0.003760 0.00776
0.8 6.31 0.9770 0.00576 0.001020 0.003760 0.00776
0.9 7.94 0.9730 0.00578 0.001030 0.003770 0.00779
1.0 10.00 0.9730 0.00578 0.001030 0.003770 0.00779
1.1 12.60 0.9660 0.00581 0.001030 0.003790 0.00784
1.2 15.80 0.9660 0.00581 0.001030 0.003790 0.00784
1.3 20.00 0.9660 0.00581 0.001030 0.003790 0.00784
1.4 25.10 0.9560 0.00587 0.001040 0.003830 0.00791
1.5 31.60 0.9510 0.00590 0.001050 0.003840 0.00795
1.6 39.80 0.9470 0.00562 0.001020 0.003620 0.00762
1.7 50.10 0.9470 0.00562 0.001020 0.003620 0.00762
1.8 63.10 0.9360 0.00569 0.001030 0.003670 0.00772
1.9 79.40 0.9240 0.00560 0.001030 0.003580 0.00761
2.0 100.00 0.9100 0.00552 0.001030 0.003500 0.00754
2.1 126.00 0.8860 0.00568 0.001060 0.003600 0.00776
2.2 158.00 0.8660 0.00564 0.001070 0.003540 0.00773
2.3 200.00 0.8400 0.00563 0.001080 0.003500 0.00775
2.4 251.00 0.8310 0.00550 0.001070 0.003400 0.00761
2.5 316.00 0.8130 0.00527 0.001060 0.003190 0.00734
2.6 398.00 0.7360 0.00503 0.001090 0.002900 0.00716
2.7 501.00 0.6780 0.00548 0.001190 0.003150 0.00781
2.8 631.00 0.6200 0.00579 0.001290 0.003270 0.00831
2.9 794.00 0.5480 0.00655 0.001470 0.003670 0.00942
3.0 1000.00 0.4750 0.00648 0.001580 0.003380 0.00959
3.1 1260.00 0.4220 0.00648 0.001710 0.003140 0.00982
3.2 1580.00 0.3250 0.00669 0.002010 0.002750 0.01060
3.3 2000.00 0.2650 0.00673 0.002200 0.002420 0.01100
3.4 2510.00 0.2370 0.00727 0.002530 0.002320 0.01220
3.5 3160.00 0.1710 0.00913 0.003350 0.002570 0.01570
3.6 3980.00 0.1350 0.00953 0.003950 0.001780 0.01730
3.7 5010.00 0.0950 0.00992 0.004830 0.000462 0.01940
3.8 6310.00 0.0745 0.01000 0.005310 -0.000403 0.02040
3.9 7940.00 0.0654 0.00763 0.005130 -0.002420 0.01770
4.0 10000.00 0.0451 0.01110 0.007840 -0.004290 0.02640
4.1 12600.00 0.0451 0.01110 0.007840 -0.004290 0.02640

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.228 0.164 -0.0942 0.549
0.1 0.9830 1.26 0.241 0.171 -0.0941 0.577
0.2 0.9830 1.58 0.241 0.171 -0.0941 0.577
0.3 0.9830 2.00 0.241 0.171 -0.0941 0.577
0.4 0.9830 2.51 0.241 0.171 -0.0941 0.577
0.5 0.9820 3.16 0.241 0.171 -0.0943 0.577
0.6 0.9820 3.98 0.241 0.171 -0.0943 0.577
0.7 0.9770 5.01 0.241 0.172 -0.0953 0.578
0.8 0.9770 6.31 0.241 0.172 -0.0953 0.578
0.9 0.9730 7.94 0.241 0.172 -0.0963 0.579
1.0 0.9730 10.00 0.241 0.172 -0.0963 0.579
1.1 0.9660 12.60 0.241 0.173 -0.0976 0.580
1.2 0.9660 15.80 0.241 0.173 -0.0976 0.580
1.3 0.9660 20.00 0.241 0.173 -0.0976 0.580
1.4 0.9560 25.10 0.241 0.174 -0.0994 0.582
1.5 0.9510 31.60 0.241 0.174 -0.1000 0.583
1.6 0.9470 39.80 0.241 0.172 -0.0953 0.578
1.7 0.9470 50.10 0.241 0.172 -0.0953 0.578
1.8 0.9360 63.10 0.241 0.173 -0.0981 0.581
1.9 0.9240 79.40 0.241 0.173 -0.0970 0.580
2.0 0.9100 100.00 0.241 0.173 -0.0969 0.580
2.1 0.8860 126.00 0.241 0.176 -0.1030 0.586
2.2 0.8660 158.00 0.241 0.177 -0.1050 0.588
2.3 0.8400 200.00 0.241 0.178 -0.1080 0.591
2.4 0.8310 251.00 0.241 0.177 -0.1060 0.589
2.5 0.8130 316.00 0.241 0.176 -0.1030 0.586
2.6 0.7360 398.00 0.241 0.179 -0.1090 0.591
2.7 0.6780 501.00 0.241 0.189 -0.1290 0.612
2.8 0.6200 631.00 0.241 0.200 -0.1500 0.633
2.9 0.5480 794.00 0.241 0.220 -0.1890 0.672
3.0 0.4750 1000.00 0.241 0.233 -0.2150 0.698
3.1 0.4220 1260.00 0.241 0.247 -0.2430 0.725
3.2 0.3250 1580.00 0.241 0.283 -0.3120 0.795
3.3 0.2650 2000.00 0.241 0.306 -0.3580 0.841
3.4 0.2370 2510.00 0.241 0.346 -0.4360 0.919
3.5 0.1710 3160.00 0.241 0.448 -0.6370 1.120
3.6 0.1350 3980.00 0.241 0.525 -0.7870 1.270
3.7 0.0950 5010.00 0.241 0.636 -1.0100 1.490
3.8 0.0745 6310.00 0.241 0.698 -1.1300 1.610
3.9 0.0654 7940.00 0.241 0.675 -1.0800 1.560
4.0 0.0451 10000.00 0.241 1.020 -1.7600 2.250
4.1 0.0451 12600.00 0.241 1.020 -1.7600 2.250

Combined HVTN 705 + RV144 analyses (24 month)

  • Adjustment covariates: Region (RV144, South Africa, Outside South Africa), age above or below 26
  • Event time variable: HIVwk26fu (RV144) and Ttilde.D210 (HVTN 705)
  • Event type variable: HIVwk26 (RV144) and Delta.D210 (HVTN 705)
  • Weight variable: sample_weight (RV144) and wt.D210 (HVTN 705)
  • Reference timepoint: 459 days (earliest between RV144 and HVTN 705)
  • Filter for HVTN 705: !is.na(Ttilde.D210)
  • All learners: GLM

IgG V1V2 B.CaseA-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00871 0.00104 6.67e-03 0.01070
0.1 0.9830 1.26 0.00871 0.00122 6.32e-03 0.01110
0.2 0.9830 1.58 0.00871 0.00122 6.32e-03 0.01110
0.3 0.9830 2.00 0.00871 0.00122 6.32e-03 0.01110
0.4 0.9820 2.51 0.00871 0.00122 6.32e-03 0.01110
0.5 0.9820 3.16 0.00871 0.00122 6.32e-03 0.01110
0.6 0.9820 3.98 0.00871 0.00122 6.32e-03 0.01110
0.7 0.9820 5.01 0.00871 0.00122 6.32e-03 0.01110
0.8 0.9800 6.31 0.00871 0.00122 6.32e-03 0.01110
0.9 0.9800 7.94 0.00871 0.00122 6.32e-03 0.01110
1.0 0.9780 10.00 0.00871 0.00122 6.32e-03 0.01110
1.1 0.9760 12.60 0.00871 0.00122 6.31e-03 0.01110
1.2 0.9690 15.80 0.00871 0.00124 6.28e-03 0.01110
1.3 0.9620 20.00 0.00871 0.00124 6.27e-03 0.01110
1.4 0.9600 25.10 0.00871 0.00123 6.29e-03 0.01110
1.5 0.9540 31.60 0.00871 0.00125 6.26e-03 0.01120
1.6 0.9450 39.80 0.00871 0.00126 6.24e-03 0.01120
1.7 0.9380 50.10 0.00855 0.00125 6.09e-03 0.01100
1.8 0.9170 63.10 0.00831 0.00125 5.86e-03 0.01070
1.9 0.9150 79.40 0.00805 0.00122 5.65e-03 0.01050
2.0 0.9020 100.00 0.00805 0.00124 5.61e-03 0.01050
2.1 0.8880 126.00 0.00792 0.00123 5.51e-03 0.01030
2.2 0.8650 158.00 0.00792 0.00125 5.47e-03 0.01040
2.3 0.8160 200.00 0.00792 0.00125 5.47e-03 0.01040
2.4 0.7780 251.00 0.00792 0.00129 5.39e-03 0.01050
2.5 0.7250 316.00 0.00792 0.00131 5.35e-03 0.01050
2.6 0.6690 398.00 0.00792 0.00134 5.30e-03 0.01060
2.7 0.6130 501.00 0.00792 0.00145 5.08e-03 0.01080
2.8 0.5240 631.00 0.00792 0.00156 4.87e-03 0.01100
2.9 0.4900 794.00 0.00792 0.00157 4.84e-03 0.01100
3.0 0.4190 1000.00 0.00730 0.00155 4.26e-03 0.01030
3.1 0.3610 1260.00 0.00685 0.00160 3.72e-03 0.00999
3.2 0.2960 1580.00 0.00676 0.00168 3.47e-03 0.01000
3.3 0.2260 2000.00 0.00676 0.00198 2.88e-03 0.01060
3.4 0.1870 2510.00 0.00668 0.00217 2.42e-03 0.01090
3.5 0.1560 3160.00 0.00668 0.00209 2.57e-03 0.01080
3.6 0.1250 3980.00 0.00668 0.00298 8.43e-04 0.01250
3.7 0.0969 5010.00 0.00668 0.00325 3.00e-04 0.01310
3.8 0.0671 6310.00 0.00481 0.00180 1.29e-03 0.00833
3.9 0.0547 7940.00 0.00481 0.00184 1.20e-03 0.00842
4.0 0.0447 10000.00 0.00481 0.00247 -3.97e-05 0.00966
4.1 0.0379 12600.00 0.00481 0.00303 -1.13e-03 0.01080
4.2 0.0306 15800.00 0.00481 0.00323 -1.52e-03 0.01110
4.3 0.0225 20000.00 0.00409 0.00272 -1.25e-03 0.00943

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00870 0.00104 0.006720 0.01150
0.1 1.26 0.9830 0.00867 0.00122 0.006280 0.01110
0.2 1.58 0.9830 0.00867 0.00122 0.006280 0.01110
0.3 2.00 0.9830 0.00867 0.00122 0.006280 0.01110
0.4 2.51 0.9820 0.00868 0.00122 0.006290 0.01110
0.5 3.16 0.9820 0.00868 0.00122 0.006290 0.01110
0.6 3.98 0.9820 0.00868 0.00122 0.006290 0.01110
0.7 5.01 0.9820 0.00868 0.00122 0.006290 0.01110
0.8 6.31 0.9800 0.00868 0.00122 0.006290 0.01110
0.9 7.94 0.9800 0.00868 0.00122 0.006290 0.01110
1.0 10.00 0.9780 0.00869 0.00122 0.006300 0.01110
1.1 12.60 0.9760 0.00871 0.00122 0.006310 0.01110
1.2 15.80 0.9690 0.00881 0.00124 0.006380 0.01120
1.3 20.00 0.9620 0.00883 0.00124 0.006400 0.01130
1.4 25.10 0.9600 0.00871 0.00123 0.006290 0.01110
1.5 31.60 0.9540 0.00879 0.00125 0.006340 0.01120
1.6 39.80 0.9450 0.00877 0.00126 0.006300 0.01120
1.7 50.10 0.9380 0.00855 0.00125 0.006090 0.01100
1.8 63.10 0.9170 0.00831 0.00125 0.005860 0.01070
1.9 79.40 0.9150 0.00804 0.00122 0.005640 0.01040
2.0 100.00 0.9020 0.00806 0.00124 0.005620 0.01050
2.1 126.00 0.8880 0.00786 0.00123 0.005450 0.01030
2.2 158.00 0.8650 0.00790 0.00125 0.005450 0.01030
2.3 200.00 0.8160 0.00772 0.00125 0.005270 0.01020
2.4 251.00 0.7780 0.00779 0.00129 0.005260 0.01030
2.5 316.00 0.7250 0.00779 0.00131 0.005210 0.01040
2.6 398.00 0.6690 0.00759 0.00134 0.004970 0.01020
2.7 501.00 0.6130 0.00811 0.00145 0.005260 0.01100
2.8 631.00 0.5240 0.00845 0.00156 0.005400 0.01150
2.9 794.00 0.4900 0.00821 0.00157 0.005120 0.01130
3.0 1000.00 0.4190 0.00730 0.00155 0.004260 0.01030
3.1 1260.00 0.3610 0.00685 0.00160 0.003720 0.00999
3.2 1580.00 0.2960 0.00669 0.00168 0.003400 0.00998
3.3 2000.00 0.2260 0.00684 0.00198 0.002960 0.01070
3.4 2510.00 0.1870 0.00661 0.00217 0.002350 0.01090
3.5 3160.00 0.1560 0.00602 0.00209 0.001910 0.01010
3.6 3980.00 0.1250 0.00693 0.00298 0.001090 0.01280
3.7 5010.00 0.0969 0.00725 0.00325 0.000876 0.01360
3.8 6310.00 0.0671 0.00429 0.00180 0.000771 0.00781
3.9 7940.00 0.0547 0.00381 0.00184 0.000201 0.00742
4.0 10000.00 0.0447 0.00513 0.00247 0.000282 0.00998
4.1 12600.00 0.0379 0.00553 0.00303 -0.000410 0.01150
4.2 15800.00 0.0306 0.00528 0.00323 -0.001040 0.01160
4.3 20000.00 0.0225 0.00409 0.00272 -0.001250 0.00943

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.289 0.113 0.0671 0.510
0.1 0.9830 1.26 0.289 0.124 0.0447 0.532
0.2 0.9830 1.58 0.289 0.124 0.0447 0.532
0.3 0.9830 2.00 0.289 0.124 0.0447 0.532
0.4 0.9820 2.51 0.289 0.124 0.0446 0.533
0.5 0.9820 3.16 0.289 0.124 0.0446 0.533
0.6 0.9820 3.98 0.289 0.124 0.0446 0.533
0.7 0.9820 5.01 0.289 0.124 0.0446 0.533
0.8 0.9800 6.31 0.289 0.125 0.0445 0.533
0.9 0.9800 7.94 0.289 0.125 0.0445 0.533
1.0 0.9780 10.00 0.289 0.125 0.0444 0.533
1.1 0.9760 12.60 0.289 0.125 0.0440 0.533
1.2 0.9690 15.80 0.289 0.126 0.0420 0.535
1.3 0.9620 20.00 0.289 0.126 0.0415 0.536
1.4 0.9600 25.10 0.289 0.125 0.0427 0.535
1.5 0.9540 31.60 0.289 0.126 0.0407 0.536
1.6 0.9450 39.80 0.289 0.127 0.0397 0.538
1.7 0.9380 50.10 0.302 0.126 0.0553 0.549
1.8 0.9170 63.10 0.322 0.124 0.0782 0.565
1.9 0.9150 79.40 0.343 0.122 0.1040 0.581
2.0 0.9020 100.00 0.343 0.123 0.1020 0.583
2.1 0.8880 126.00 0.353 0.121 0.1150 0.591
2.2 0.8650 158.00 0.353 0.123 0.1130 0.593
2.3 0.8160 200.00 0.353 0.123 0.1120 0.594
2.4 0.7780 251.00 0.353 0.125 0.1070 0.599
2.5 0.7250 316.00 0.353 0.127 0.1040 0.602
2.6 0.6690 398.00 0.353 0.129 0.1000 0.605
2.7 0.6130 501.00 0.353 0.137 0.0849 0.621
2.8 0.5240 631.00 0.353 0.144 0.0698 0.636
2.9 0.4900 794.00 0.353 0.145 0.0679 0.638
3.0 0.4190 1000.00 0.404 0.141 0.1270 0.681
3.1 0.3610 1260.00 0.440 0.143 0.1590 0.721
3.2 0.2960 1580.00 0.448 0.149 0.1560 0.740
3.3 0.2260 2000.00 0.448 0.172 0.1110 0.784
3.4 0.1870 2510.00 0.455 0.187 0.0888 0.820
3.5 0.1560 3160.00 0.455 0.180 0.1010 0.808
3.6 0.1250 3980.00 0.455 0.250 -0.0352 0.944
3.7 0.0969 5010.00 0.455 0.272 -0.0784 0.987
3.8 0.0671 6310.00 0.607 0.152 0.3090 0.906
3.9 0.0547 7940.00 0.607 0.156 0.3020 0.913
4.0 0.0447 10000.00 0.607 0.206 0.2030 1.010
4.1 0.0379 12600.00 0.607 0.251 0.1150 1.100
4.2 0.0306 15800.00 0.607 0.267 0.0844 1.130
4.3 0.0225 20000.00 0.666 0.225 0.2250 1.110

IgG V1V2 AE.A244-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00899 0.001040 6.96e-03 0.01100
0.1 0.995 1.26 0.00899 0.001210 6.61e-03 0.01140
0.2 0.995 1.58 0.00899 0.001210 6.61e-03 0.01140
0.3 0.995 2.00 0.00899 0.001210 6.61e-03 0.01140
0.4 0.995 2.51 0.00899 0.001210 6.61e-03 0.01140
0.5 0.995 3.16 0.00899 0.001210 6.61e-03 0.01140
0.6 0.995 3.98 0.00899 0.001210 6.61e-03 0.01140
0.7 0.994 5.01 0.00899 0.001200 6.63e-03 0.01130
0.8 0.992 6.31 0.00899 0.001200 6.63e-03 0.01130
0.9 0.992 7.94 0.00899 0.001190 6.65e-03 0.01130
1.0 0.992 10.00 0.00899 0.001190 6.65e-03 0.01130
1.1 0.992 12.60 0.00899 0.001190 6.66e-03 0.01130
1.2 0.991 15.80 0.00899 0.001190 6.65e-03 0.01130
1.3 0.991 20.00 0.00899 0.001190 6.65e-03 0.01130
1.4 0.990 25.10 0.00899 0.001190 6.65e-03 0.01130
1.5 0.989 31.60 0.00899 0.001200 6.63e-03 0.01130
1.6 0.989 39.80 0.00899 0.001200 6.63e-03 0.01130
1.7 0.989 50.10 0.00899 0.001210 6.62e-03 0.01130
1.8 0.986 63.10 0.00899 0.001220 6.60e-03 0.01140
1.9 0.985 79.40 0.00899 0.001220 6.59e-03 0.01140
2.0 0.985 100.00 0.00899 0.001210 6.61e-03 0.01140
2.1 0.979 126.00 0.00899 0.001230 6.57e-03 0.01140
2.2 0.972 158.00 0.00899 0.001250 6.53e-03 0.01140
2.3 0.970 200.00 0.00899 0.001260 6.52e-03 0.01150
2.4 0.962 251.00 0.00899 0.001320 6.39e-03 0.01160
2.5 0.953 316.00 0.00899 0.001380 6.28e-03 0.01170
2.6 0.947 398.00 0.00899 0.001390 6.26e-03 0.01170
2.7 0.931 501.00 0.00899 0.001460 6.13e-03 0.01180
2.8 0.925 631.00 0.00899 0.001450 6.13e-03 0.01180
2.9 0.917 794.00 0.00899 0.001520 6.00e-03 0.01200
3.0 0.907 1000.00 0.00899 0.001660 5.74e-03 0.01220
3.1 0.895 1260.00 0.00899 0.001910 5.24e-03 0.01270
3.2 0.876 1580.00 0.00899 0.001940 5.19e-03 0.01280
3.3 0.862 2000.00 0.00899 0.002430 4.23e-03 0.01370
3.4 0.853 2510.00 0.00784 0.002290 3.34e-03 0.01230
3.5 0.838 3160.00 0.00728 0.002230 2.91e-03 0.01160
3.6 0.814 3980.00 0.00728 0.003010 1.38e-03 0.01320
3.7 0.788 5010.00 0.00620 0.003010 2.93e-04 0.01210
3.8 0.746 6310.00 0.00230 0.000708 9.13e-04 0.00369
3.9 0.700 7940.00 0.00230 0.000708 9.13e-04 0.00369
4.0 0.638 10000.00 0.00230 0.000790 7.51e-04 0.00385
4.1 0.541 12600.00 0.00230 0.000991 3.58e-04 0.00424
4.2 0.498 15800.00 0.00230 0.000963 4.13e-04 0.00419
4.3 0.413 20000.00 0.00230 0.000863 6.08e-04 0.00399
4.4 0.205 25100.00 0.00230 0.001220 -9.17e-05 0.00469

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00870 0.001040 0.006720 0.01150
0.1 1.26 0.995 0.00904 0.001210 0.006660 0.01140
0.2 1.58 0.995 0.00904 0.001210 0.006660 0.01140
0.3 2.00 0.995 0.00904 0.001210 0.006660 0.01140
0.4 2.51 0.995 0.00904 0.001210 0.006660 0.01140
0.5 3.16 0.995 0.00904 0.001210 0.006660 0.01140
0.6 3.98 0.995 0.00904 0.001210 0.006660 0.01140
0.7 5.01 0.994 0.00892 0.001200 0.006560 0.01130
0.8 6.31 0.992 0.00892 0.001200 0.006560 0.01130
0.9 7.94 0.992 0.00879 0.001190 0.006450 0.01110
1.0 10.00 0.992 0.00879 0.001190 0.006450 0.01110
1.1 12.60 0.992 0.00869 0.001190 0.006360 0.01100
1.2 15.80 0.991 0.00871 0.001190 0.006380 0.01100
1.3 20.00 0.991 0.00871 0.001190 0.006380 0.01100
1.4 25.10 0.990 0.00875 0.001190 0.006400 0.01110
1.5 31.60 0.989 0.00879 0.001200 0.006430 0.01110
1.6 39.80 0.989 0.00881 0.001200 0.006450 0.01120
1.7 50.10 0.989 0.00883 0.001210 0.006460 0.01120
1.8 63.10 0.986 0.00890 0.001220 0.006510 0.01130
1.9 79.40 0.985 0.00894 0.001220 0.006540 0.01130
2.0 100.00 0.985 0.00883 0.001210 0.006450 0.01120
2.1 126.00 0.979 0.00889 0.001230 0.006480 0.01130
2.2 158.00 0.972 0.00891 0.001250 0.006450 0.01140
2.3 200.00 0.970 0.00887 0.001260 0.006400 0.01130
2.4 251.00 0.962 0.00928 0.001320 0.006690 0.01190
2.5 316.00 0.953 0.00956 0.001380 0.006860 0.01230
2.6 398.00 0.947 0.00938 0.001390 0.006650 0.01210
2.7 501.00 0.931 0.00941 0.001460 0.006560 0.01230
2.8 631.00 0.925 0.00893 0.001450 0.006080 0.01180
2.9 794.00 0.917 0.00895 0.001520 0.005960 0.01190
3.0 1000.00 0.907 0.00931 0.001660 0.006060 0.01260
3.1 1260.00 0.895 0.01000 0.001910 0.006250 0.01370
3.2 1580.00 0.876 0.00868 0.001940 0.004880 0.01250
3.3 2000.00 0.862 0.00954 0.002430 0.004780 0.01430
3.4 2510.00 0.853 0.00784 0.002290 0.003340 0.01230
3.5 3160.00 0.838 0.00689 0.002230 0.002520 0.01130
3.6 3980.00 0.814 0.00768 0.003010 0.001780 0.01360
3.7 5010.00 0.788 0.00620 0.003010 0.000293 0.01210
3.8 6310.00 0.746 0.00226 0.000708 0.000876 0.00365
3.9 7940.00 0.700 0.00222 0.000708 0.000827 0.00360
4.0 10000.00 0.638 0.00228 0.000790 0.000726 0.00382
4.1 12600.00 0.541 0.00245 0.000991 0.000510 0.00439
4.2 15800.00 0.498 0.00231 0.000963 0.000425 0.00420
4.3 20000.00 0.413 0.00561 0.000863 0.003920 0.00730
4.4 25100.00 0.205 0.00643 0.001220 0.004040 0.00883

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.265 0.1150 0.040700 0.490
0.1 0.995 1.26 0.265 0.1260 0.019300 0.512
0.2 0.995 1.58 0.265 0.1260 0.019300 0.512
0.3 0.995 2.00 0.265 0.1260 0.019300 0.512
0.4 0.995 2.51 0.265 0.1260 0.019300 0.512
0.5 0.995 3.16 0.265 0.1260 0.019300 0.512
0.6 0.995 3.98 0.265 0.1260 0.019300 0.512
0.7 0.994 5.01 0.266 0.1250 0.021100 0.511
0.8 0.992 6.31 0.266 0.1250 0.021000 0.511
0.9 0.992 7.94 0.266 0.1240 0.022300 0.510
1.0 0.992 10.00 0.266 0.1240 0.022300 0.510
1.1 0.992 12.60 0.266 0.1240 0.023300 0.509
1.2 0.991 15.80 0.266 0.1240 0.022900 0.509
1.3 0.991 20.00 0.266 0.1240 0.022900 0.509
1.4 0.990 25.10 0.266 0.1240 0.022400 0.510
1.5 0.989 31.60 0.266 0.1250 0.021600 0.510
1.6 0.989 39.80 0.266 0.1250 0.021300 0.511
1.7 0.989 50.10 0.266 0.1250 0.020900 0.511
1.8 0.986 63.10 0.266 0.1260 0.019600 0.512
1.9 0.985 79.40 0.266 0.1260 0.018900 0.513
2.0 0.985 100.00 0.266 0.1260 0.019800 0.512
2.1 0.979 126.00 0.266 0.1270 0.017500 0.514
2.2 0.972 158.00 0.266 0.1280 0.014700 0.517
2.3 0.970 200.00 0.266 0.1290 0.014000 0.518
2.4 0.962 251.00 0.266 0.1330 0.005710 0.526
2.5 0.953 316.00 0.266 0.1370 -0.001940 0.534
2.6 0.947 398.00 0.266 0.1370 -0.003170 0.535
2.7 0.931 501.00 0.266 0.1420 -0.012000 0.544
2.8 0.925 631.00 0.266 0.1420 -0.011600 0.544
2.9 0.917 794.00 0.266 0.1460 -0.021000 0.553
3.0 0.907 1000.00 0.266 0.1560 -0.039100 0.571
3.1 0.895 1260.00 0.266 0.1740 -0.075500 0.607
3.2 0.876 1580.00 0.266 0.1760 -0.079100 0.611
3.3 0.862 2000.00 0.266 0.2130 -0.151000 0.683
3.4 0.853 2510.00 0.360 0.1990 -0.030500 0.750
3.5 0.838 3160.00 0.406 0.1920 0.028800 0.783
3.6 0.814 3980.00 0.406 0.2530 -0.091000 0.902
3.7 0.788 5010.00 0.494 0.2520 0.000786 0.987
3.8 0.746 6310.00 0.812 0.0611 0.692000 0.932
3.9 0.700 7940.00 0.812 0.0611 0.692000 0.932
4.0 0.638 10000.00 0.812 0.0675 0.680000 0.944
4.1 0.541 12600.00 0.812 0.0833 0.649000 0.975
4.2 0.498 15800.00 0.812 0.0811 0.653000 0.971
4.3 0.413 20000.00 0.812 0.0732 0.669000 0.956
4.4 0.205 25100.00 0.812 0.1020 0.613000 1.010

IgG V1V2 C.1086-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00895 0.00104 0.00692 0.01100
0.1 0.9940 1.26 0.00895 0.00120 0.00661 0.01130
0.2 0.9930 1.58 0.00895 0.00120 0.00661 0.01130
0.3 0.9930 2.00 0.00895 0.00120 0.00661 0.01130
0.4 0.9920 2.51 0.00895 0.00120 0.00661 0.01130
0.5 0.9920 3.16 0.00895 0.00120 0.00661 0.01130
0.6 0.9920 3.98 0.00895 0.00120 0.00661 0.01130
0.7 0.9920 5.01 0.00895 0.00120 0.00661 0.01130
0.8 0.9920 6.31 0.00895 0.00120 0.00661 0.01130
0.9 0.9920 7.94 0.00895 0.00120 0.00661 0.01130
1.0 0.9920 10.00 0.00895 0.00119 0.00663 0.01130
1.1 0.9920 12.60 0.00895 0.00118 0.00665 0.01130
1.2 0.9910 15.80 0.00895 0.00118 0.00663 0.01130
1.3 0.9890 20.00 0.00895 0.00119 0.00662 0.01130
1.4 0.9890 25.10 0.00895 0.00118 0.00664 0.01130
1.5 0.9850 31.60 0.00895 0.00120 0.00661 0.01130
1.6 0.9800 39.80 0.00895 0.00122 0.00657 0.01130
1.7 0.9790 50.10 0.00895 0.00121 0.00657 0.01130
1.8 0.9760 63.10 0.00895 0.00122 0.00656 0.01130
1.9 0.9680 79.40 0.00895 0.00124 0.00652 0.01140
2.0 0.9650 100.00 0.00895 0.00125 0.00650 0.01140
2.1 0.9590 126.00 0.00895 0.00131 0.00639 0.01150
2.2 0.9490 158.00 0.00895 0.00135 0.00632 0.01160
2.3 0.9440 200.00 0.00895 0.00136 0.00628 0.01160
2.4 0.9370 251.00 0.00895 0.00145 0.00611 0.01180
2.5 0.9120 316.00 0.00895 0.00155 0.00591 0.01200
2.6 0.8970 398.00 0.00895 0.00154 0.00593 0.01200
2.7 0.8820 501.00 0.00895 0.00183 0.00537 0.01250
2.8 0.8660 631.00 0.00895 0.00194 0.00516 0.01270
2.9 0.8560 794.00 0.00895 0.00196 0.00512 0.01280
3.0 0.8420 1000.00 0.00895 0.00202 0.00500 0.01290
3.1 0.8080 1260.00 0.00895 0.00259 0.00387 0.01400
3.2 0.7570 1580.00 0.00719 0.00226 0.00276 0.01160
3.3 0.7060 2000.00 0.00542 0.00178 0.00194 0.00890
3.4 0.6550 2510.00 0.00542 0.00206 0.00138 0.00946
3.5 0.5590 3160.00 0.00542 0.00340 -0.00124 0.01210
3.6 0.4860 3980.00 0.00542 0.00430 -0.00301 0.01380
3.7 0.4110 5010.00 0.00542 0.00443 -0.00327 0.01410
3.8 0.3430 6310.00 0.00542 0.00463 -0.00365 0.01450
3.9 0.2490 7940.00 0.00542 0.00522 -0.00482 0.01570
4.0 0.1750 10000.00 0.00542 0.00608 -0.00650 0.01730
4.1 0.1390 12600.00 0.00542 0.00764 -0.00956 0.02040
4.2 0.0994 15800.00 0.00542 0.00795 -0.01020 0.02100

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00870 0.00104 0.006720 0.01150
0.1 1.26 0.9940 0.00881 0.00120 0.006460 0.01120
0.2 1.58 0.9930 0.00881 0.00120 0.006470 0.01120
0.3 2.00 0.9930 0.00881 0.00120 0.006470 0.01120
0.4 2.51 0.9920 0.00882 0.00120 0.006470 0.01120
0.5 3.16 0.9920 0.00882 0.00120 0.006470 0.01120
0.6 3.98 0.9920 0.00882 0.00120 0.006470 0.01120
0.7 5.01 0.9920 0.00882 0.00120 0.006470 0.01120
0.8 6.31 0.9920 0.00882 0.00120 0.006470 0.01120
0.9 7.94 0.9920 0.00882 0.00120 0.006470 0.01120
1.0 10.00 0.9920 0.00869 0.00119 0.006360 0.01100
1.1 12.60 0.9920 0.00856 0.00118 0.006250 0.01090
1.2 15.80 0.9910 0.00860 0.00118 0.006280 0.01090
1.3 20.00 0.9890 0.00865 0.00119 0.006320 0.01100
1.4 25.10 0.9890 0.00852 0.00118 0.006210 0.01080
1.5 31.60 0.9850 0.00864 0.00120 0.006290 0.01100
1.6 39.80 0.9800 0.00879 0.00122 0.006400 0.01120
1.7 50.10 0.9790 0.00870 0.00121 0.006320 0.01110
1.8 63.10 0.9760 0.00868 0.00122 0.006290 0.01110
1.9 79.40 0.9680 0.00881 0.00124 0.006380 0.01120
2.0 100.00 0.9650 0.00883 0.00125 0.006370 0.01130
2.1 126.00 0.9590 0.00916 0.00131 0.006610 0.01170
2.2 158.00 0.9490 0.00921 0.00135 0.006570 0.01180
2.3 200.00 0.9440 0.00914 0.00136 0.006470 0.01180
2.4 251.00 0.9370 0.00967 0.00145 0.006820 0.01250
2.5 316.00 0.9120 0.00981 0.00155 0.006770 0.01290
2.6 398.00 0.8970 0.00922 0.00154 0.006190 0.01220
2.7 501.00 0.8820 0.01030 0.00183 0.006720 0.01390
2.8 631.00 0.8660 0.00959 0.00194 0.005800 0.01340
2.9 794.00 0.8560 0.00865 0.00196 0.004820 0.01250
3.0 1000.00 0.8420 0.00854 0.00202 0.004590 0.01250
3.1 1260.00 0.8080 0.01060 0.00259 0.005540 0.01570
3.2 1580.00 0.7570 0.00719 0.00226 0.002760 0.01160
3.3 2000.00 0.7060 0.00458 0.00178 0.001110 0.00806
3.4 2510.00 0.6550 0.00481 0.00206 0.000773 0.00885
3.5 3160.00 0.5590 0.00648 0.00340 -0.000180 0.01310
3.6 3980.00 0.4860 0.00602 0.00430 -0.002400 0.01440
3.7 5010.00 0.4110 0.00718 0.00443 -0.001500 0.01590
3.8 6310.00 0.3430 0.00799 0.00463 -0.001070 0.01710
3.9 7940.00 0.2490 0.00845 0.00522 -0.001780 0.01870
4.0 10000.00 0.1750 0.00924 0.00608 -0.002680 0.02120
4.1 12600.00 0.1390 0.01230 0.00764 -0.002680 0.02730
4.2 15800.00 0.0994 0.01200 0.00795 -0.003580 0.02760

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.269 0.114 0.04450 0.493
0.1 0.9940 1.26 0.269 0.124 0.02510 0.512
0.2 0.9930 1.58 0.269 0.124 0.02500 0.512
0.3 0.9930 2.00 0.269 0.124 0.02500 0.512
0.4 0.9920 2.51 0.269 0.124 0.02500 0.512
0.5 0.9920 3.16 0.269 0.124 0.02500 0.512
0.6 0.9920 3.98 0.269 0.124 0.02500 0.512
0.7 0.9920 5.01 0.269 0.124 0.02500 0.512
0.8 0.9920 6.31 0.269 0.124 0.02500 0.512
0.9 0.9920 7.94 0.269 0.124 0.02500 0.512
1.0 0.9920 10.00 0.269 0.124 0.02630 0.511
1.1 0.9920 12.60 0.269 0.123 0.02760 0.510
1.2 0.9910 15.80 0.269 0.123 0.02680 0.511
1.3 0.9890 20.00 0.269 0.124 0.02610 0.511
1.4 0.9890 25.10 0.269 0.123 0.02740 0.510
1.5 0.9850 31.60 0.269 0.124 0.02520 0.512
1.6 0.9800 39.80 0.269 0.126 0.02240 0.515
1.7 0.9790 50.10 0.269 0.125 0.02300 0.514
1.8 0.9760 63.10 0.269 0.126 0.02210 0.515
1.9 0.9680 79.40 0.269 0.127 0.01960 0.518
2.0 0.9650 100.00 0.269 0.128 0.01790 0.519
2.1 0.9590 126.00 0.269 0.131 0.01120 0.526
2.2 0.9490 158.00 0.269 0.134 0.00591 0.532
2.3 0.9440 200.00 0.269 0.135 0.00379 0.534
2.4 0.9370 251.00 0.269 0.141 -0.00808 0.546
2.5 0.9120 316.00 0.269 0.148 -0.02180 0.559
2.6 0.8970 398.00 0.269 0.148 -0.02070 0.558
2.7 0.8820 501.00 0.269 0.168 -0.06020 0.598
2.8 0.8660 631.00 0.269 0.176 -0.07600 0.613
2.9 0.8560 794.00 0.269 0.177 -0.07880 0.616
3.0 0.8420 1000.00 0.269 0.182 -0.08780 0.625
3.1 0.8080 1260.00 0.269 0.225 -0.17300 0.710
3.2 0.7570 1580.00 0.412 0.195 0.03040 0.794
3.3 0.7060 2000.00 0.558 0.152 0.25900 0.856
3.4 0.6550 2510.00 0.558 0.175 0.21500 0.900
3.5 0.5590 3160.00 0.558 0.281 0.00614 1.110
3.6 0.4860 3980.00 0.558 0.354 -0.13600 1.250
3.7 0.4110 5010.00 0.558 0.365 -0.15800 1.270
3.8 0.3430 6310.00 0.558 0.381 -0.18900 1.300
3.9 0.2490 7940.00 0.558 0.429 -0.28300 1.400
4.0 0.1750 10000.00 0.558 0.499 -0.42100 1.540
4.1 0.1390 12600.00 0.558 0.626 -0.66900 1.780
4.2 0.0994 15800.00 0.558 0.651 -0.71800 1.830

IgG V1V2 C.1086-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00909 0.00104 0.00705 0.0111
0.1 0.993 1.26 0.00909 0.00123 0.00668 0.0115
0.2 0.993 1.58 0.00909 0.00123 0.00668 0.0115
0.3 0.993 2.00 0.00909 0.00123 0.00668 0.0115
0.4 0.991 2.51 0.00909 0.00123 0.00668 0.0115
0.5 0.990 3.16 0.00909 0.00123 0.00668 0.0115
0.6 0.990 3.98 0.00909 0.00123 0.00668 0.0115
0.7 0.990 5.01 0.00903 0.00122 0.00664 0.0114
0.8 0.990 6.31 0.00903 0.00122 0.00664 0.0114
0.9 0.990 7.94 0.00903 0.00122 0.00664 0.0114
1.0 0.990 10.00 0.00903 0.00122 0.00664 0.0114
1.1 0.988 12.60 0.00900 0.00121 0.00663 0.0114
1.2 0.988 15.80 0.00900 0.00121 0.00663 0.0114
1.3 0.988 20.00 0.00900 0.00121 0.00663 0.0114
1.4 0.988 25.10 0.00900 0.00121 0.00662 0.0114
1.5 0.988 31.60 0.00900 0.00121 0.00662 0.0114
1.6 0.988 39.80 0.00900 0.00121 0.00662 0.0114
1.7 0.987 50.10 0.00900 0.00120 0.00664 0.0114
1.8 0.987 63.10 0.00900 0.00121 0.00663 0.0114
1.9 0.985 79.40 0.00900 0.00121 0.00663 0.0114
2.0 0.984 100.00 0.00900 0.00121 0.00662 0.0114
2.1 0.982 126.00 0.00900 0.00122 0.00661 0.0114
2.2 0.981 158.00 0.00900 0.00122 0.00661 0.0114
2.3 0.980 200.00 0.00900 0.00123 0.00659 0.0114
2.4 0.980 251.00 0.00900 0.00123 0.00659 0.0114
2.5 0.973 316.00 0.00900 0.00124 0.00657 0.0114
2.6 0.971 398.00 0.00900 0.00125 0.00654 0.0115
2.7 0.969 501.00 0.00900 0.00125 0.00655 0.0114
2.8 0.961 631.00 0.00900 0.00130 0.00646 0.0115
2.9 0.941 794.00 0.00900 0.00131 0.00642 0.0116
3.0 0.937 1000.00 0.00900 0.00134 0.00638 0.0116
3.1 0.929 1260.00 0.00900 0.00136 0.00633 0.0117
3.2 0.916 1580.00 0.00900 0.00136 0.00634 0.0117
3.3 0.894 2000.00 0.00900 0.00139 0.00627 0.0117
3.4 0.870 2510.00 0.00900 0.00141 0.00624 0.0118
3.5 0.846 3160.00 0.00900 0.00149 0.00607 0.0119
3.6 0.806 3980.00 0.00900 0.00163 0.00581 0.0122
3.7 0.723 5010.00 0.00900 0.00170 0.00567 0.0123
3.8 0.645 6310.00 0.00900 0.00171 0.00565 0.0123
3.9 0.557 7940.00 0.00900 0.00186 0.00536 0.0126
4.0 0.470 10000.00 0.00900 0.00222 0.00466 0.0133
4.1 0.386 12600.00 0.00857 0.00212 0.00441 0.0127
4.2 0.308 15800.00 0.00857 0.00235 0.00396 0.0132
4.3 0.228 20000.00 0.00857 0.00277 0.00314 0.0140

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00870 0.00104 0.00672 0.0115
0.1 1.26 0.993 0.00915 0.00123 0.00674 0.0116
0.2 1.58 0.993 0.00915 0.00123 0.00674 0.0116
0.3 2.00 0.993 0.00915 0.00123 0.00674 0.0116
0.4 2.51 0.991 0.00915 0.00123 0.00675 0.0116
0.5 3.16 0.990 0.00916 0.00123 0.00675 0.0116
0.6 3.98 0.990 0.00916 0.00123 0.00675 0.0116
0.7 5.01 0.990 0.00903 0.00122 0.00664 0.0114
0.8 6.31 0.990 0.00903 0.00122 0.00664 0.0114
0.9 7.94 0.990 0.00903 0.00122 0.00664 0.0114
1.0 10.00 0.990 0.00903 0.00122 0.00664 0.0114
1.1 12.60 0.988 0.00890 0.00121 0.00653 0.0113
1.2 15.80 0.988 0.00890 0.00121 0.00653 0.0113
1.3 20.00 0.988 0.00890 0.00121 0.00653 0.0113
1.4 25.10 0.988 0.00892 0.00121 0.00655 0.0113
1.5 31.60 0.988 0.00892 0.00121 0.00655 0.0113
1.6 39.80 0.988 0.00892 0.00121 0.00655 0.0113
1.7 50.10 0.987 0.00881 0.00120 0.00645 0.0112
1.8 63.10 0.987 0.00883 0.00121 0.00647 0.0112
1.9 79.40 0.985 0.00884 0.00121 0.00647 0.0112
2.0 100.00 0.984 0.00886 0.00121 0.00649 0.0112
2.1 126.00 0.982 0.00891 0.00122 0.00652 0.0113
2.2 158.00 0.981 0.00893 0.00122 0.00654 0.0113
2.3 200.00 0.980 0.00897 0.00123 0.00657 0.0114
2.4 251.00 0.980 0.00899 0.00123 0.00658 0.0114
2.5 316.00 0.973 0.00900 0.00124 0.00657 0.0114
2.6 398.00 0.971 0.00909 0.00125 0.00663 0.0115
2.7 501.00 0.969 0.00894 0.00125 0.00649 0.0114
2.8 631.00 0.961 0.00924 0.00130 0.00670 0.0118
2.9 794.00 0.941 0.00923 0.00131 0.00665 0.0118
3.0 1000.00 0.937 0.00929 0.00134 0.00668 0.0119
3.1 1260.00 0.929 0.00938 0.00136 0.00671 0.0120
3.2 1580.00 0.916 0.00899 0.00136 0.00633 0.0116
3.3 2000.00 0.894 0.00884 0.00139 0.00612 0.0116
3.4 2510.00 0.870 0.00865 0.00141 0.00589 0.0114
3.5 3160.00 0.846 0.00903 0.00149 0.00610 0.0120
3.6 3980.00 0.806 0.00946 0.00163 0.00627 0.0126
3.7 5010.00 0.723 0.00911 0.00170 0.00577 0.0124
3.8 6310.00 0.645 0.00852 0.00171 0.00518 0.0119
3.9 7940.00 0.557 0.00876 0.00186 0.00512 0.0124
4.0 10000.00 0.470 0.01020 0.00222 0.00583 0.0145
4.1 12600.00 0.386 0.00813 0.00212 0.00397 0.0123
4.2 15800.00 0.308 0.00826 0.00235 0.00365 0.0129
4.3 20000.00 0.228 0.00946 0.00277 0.00404 0.0149

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.258 0.115 0.032000 0.484
0.1 0.993 1.26 0.258 0.127 0.008860 0.507
0.2 0.993 1.58 0.258 0.127 0.008860 0.507
0.3 0.993 2.00 0.258 0.127 0.008860 0.507
0.4 0.991 2.51 0.258 0.127 0.008780 0.507
0.5 0.990 3.16 0.258 0.127 0.008710 0.507
0.6 0.990 3.98 0.258 0.127 0.008710 0.507
0.7 0.990 5.01 0.262 0.126 0.015200 0.510
0.8 0.990 6.31 0.262 0.126 0.015200 0.510
0.9 0.990 7.94 0.262 0.126 0.015200 0.510
1.0 0.990 10.00 0.262 0.126 0.015200 0.510
1.1 0.988 12.60 0.265 0.125 0.019400 0.511
1.2 0.988 15.80 0.265 0.125 0.019400 0.511
1.3 0.988 20.00 0.265 0.125 0.019400 0.511
1.4 0.988 25.10 0.265 0.125 0.019100 0.511
1.5 0.988 31.60 0.265 0.125 0.019100 0.511
1.6 0.988 39.80 0.265 0.125 0.019100 0.511
1.7 0.987 50.10 0.265 0.125 0.019900 0.510
1.8 0.987 63.10 0.265 0.125 0.019600 0.510
1.9 0.985 79.40 0.265 0.125 0.019500 0.510
2.0 0.984 100.00 0.265 0.125 0.019100 0.511
2.1 0.982 126.00 0.265 0.126 0.018200 0.512
2.2 0.981 158.00 0.265 0.126 0.017800 0.512
2.3 0.980 200.00 0.265 0.126 0.017100 0.513
2.4 0.980 251.00 0.265 0.127 0.016700 0.513
2.5 0.973 316.00 0.265 0.127 0.015400 0.515
2.6 0.971 398.00 0.265 0.128 0.013700 0.516
2.7 0.969 501.00 0.265 0.128 0.014200 0.516
2.8 0.961 631.00 0.265 0.131 0.008010 0.522
2.9 0.941 794.00 0.265 0.132 0.005880 0.524
3.0 0.937 1000.00 0.265 0.134 0.002980 0.527
3.1 0.929 1260.00 0.265 0.135 -0.000187 0.530
3.2 0.916 1580.00 0.265 0.135 0.000372 0.530
3.3 0.894 2000.00 0.265 0.137 -0.004330 0.534
3.4 0.870 2510.00 0.265 0.138 -0.006200 0.536
3.5 0.846 3160.00 0.265 0.144 -0.018000 0.548
3.6 0.806 3980.00 0.265 0.154 -0.036000 0.566
3.7 0.723 5010.00 0.265 0.159 -0.046400 0.576
3.8 0.645 6310.00 0.265 0.159 -0.047600 0.578
3.9 0.557 7940.00 0.265 0.170 -0.068500 0.598
4.0 0.470 10000.00 0.265 0.197 -0.121000 0.651
4.1 0.386 12600.00 0.300 0.188 -0.068800 0.669
4.2 0.308 15800.00 0.300 0.206 -0.103000 0.703
4.3 0.228 20000.00 0.300 0.238 -0.165000 0.766

IgG3 V1V2 B.CaseA-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00870 0.00104 0.006660 0.01070
0.1 0.9160 1.26 0.00851 0.00144 0.005680 0.01130
0.2 0.9110 1.58 0.00838 0.00144 0.005560 0.01120
0.3 0.9090 2.00 0.00838 0.00148 0.005490 0.01130
0.4 0.8870 2.51 0.00834 0.00147 0.005450 0.01120
0.5 0.8860 3.16 0.00826 0.00145 0.005420 0.01110
0.6 0.8690 3.98 0.00826 0.00151 0.005290 0.01120
0.7 0.8580 5.01 0.00799 0.00150 0.005040 0.01090
0.8 0.8570 6.31 0.00783 0.00150 0.004890 0.01080
0.9 0.8480 7.94 0.00782 0.00153 0.004820 0.01080
1.0 0.8200 10.00 0.00766 0.00148 0.004760 0.01050
1.1 0.7670 12.60 0.00766 0.00152 0.004670 0.01060
1.2 0.7380 15.80 0.00750 0.00150 0.004550 0.01040
1.3 0.7020 20.00 0.00735 0.00150 0.004400 0.01030
1.4 0.6650 25.10 0.00735 0.00160 0.004220 0.01050
1.5 0.6210 31.60 0.00713 0.00158 0.004040 0.01020
1.6 0.5750 39.80 0.00650 0.00152 0.003520 0.00949
1.7 0.4890 50.10 0.00650 0.00162 0.003320 0.00968
1.8 0.4480 63.10 0.00643 0.00167 0.003140 0.00971
1.9 0.3790 79.40 0.00607 0.00175 0.002640 0.00951
2.0 0.3170 100.00 0.00559 0.00177 0.002130 0.00905
2.1 0.2760 126.00 0.00559 0.00187 0.001940 0.00925
2.2 0.2270 158.00 0.00558 0.00205 0.001560 0.00959
2.3 0.2010 200.00 0.00558 0.00232 0.001030 0.01010
2.4 0.1610 251.00 0.00558 0.00236 0.000952 0.01020
2.5 0.1300 316.00 0.00558 0.00234 0.000992 0.01020
2.6 0.1020 398.00 0.00558 0.00247 0.000735 0.01040
2.7 0.0838 501.00 0.00558 0.00294 -0.000189 0.01130
2.8 0.0584 631.00 0.00558 0.00543 -0.005070 0.01620
2.9 0.0536 794.00 0.00558 0.00542 -0.005040 0.01620
3.0 0.0428 1000.00 0.00558 0.01250 -0.019000 0.03020
3.1 0.0327 1260.00 0.00558 0.01820 -0.030000 0.04120
3.2 0.0307 1580.00 0.00558 0.02400 -0.041500 0.05260
3.3 0.0304 2000.00 0.00558 0.02900 -0.051300 0.06250

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00870 0.00104 0.006720 0.01150
0.1 1.26 0.9160 0.00851 0.00144 0.005680 0.01130
0.2 1.58 0.9110 0.00830 0.00144 0.005480 0.01110
0.3 2.00 0.9090 0.00847 0.00148 0.005570 0.01140
0.4 2.51 0.8870 0.00834 0.00147 0.005450 0.01120
0.5 3.16 0.8860 0.00811 0.00145 0.005260 0.01090
0.6 3.98 0.8690 0.00842 0.00151 0.005450 0.01140
0.7 5.01 0.8580 0.00799 0.00150 0.005040 0.01090
0.8 6.31 0.8570 0.00783 0.00150 0.004890 0.01080
0.9 7.94 0.8480 0.00782 0.00153 0.004830 0.01080
1.0 10.00 0.8200 0.00764 0.00148 0.004750 0.01050
1.1 12.60 0.7670 0.00767 0.00152 0.004690 0.01070
1.2 15.80 0.7380 0.00750 0.00150 0.004550 0.01040
1.3 20.00 0.7020 0.00715 0.00150 0.004210 0.01010
1.4 25.10 0.6650 0.00755 0.00160 0.004420 0.01070
1.5 31.60 0.6210 0.00713 0.00158 0.004040 0.01020
1.6 39.80 0.5750 0.00637 0.00152 0.003390 0.00936
1.7 50.10 0.4890 0.00664 0.00162 0.003460 0.00982
1.8 63.10 0.4480 0.00643 0.00167 0.003140 0.00971
1.9 79.40 0.3790 0.00607 0.00175 0.002640 0.00951
2.0 100.00 0.3170 0.00557 0.00177 0.002110 0.00903
2.1 126.00 0.2760 0.00561 0.00187 0.001960 0.00927
2.2 158.00 0.2270 0.00551 0.00205 0.001490 0.00953
2.3 200.00 0.2010 0.00579 0.00232 0.001240 0.01030
2.4 251.00 0.1610 0.00552 0.00236 0.000900 0.01010
2.5 316.00 0.1300 0.00481 0.00234 0.000227 0.00940
2.6 398.00 0.1020 0.00454 0.00247 -0.000305 0.00938
2.7 501.00 0.0838 0.00529 0.00294 -0.000472 0.01110
2.8 631.00 0.0584 0.00809 0.00543 -0.002550 0.01870
2.9 794.00 0.0536 0.00744 0.00542 -0.003190 0.01810
3.0 1000.00 0.0428 0.01450 0.01250 -0.010100 0.03910
3.1 1260.00 0.0327 0.02130 0.01820 -0.014300 0.05690
3.2 1580.00 0.0307 0.02540 0.02400 -0.021600 0.07250
3.3 2000.00 0.0304 0.02970 0.02900 -0.027200 0.08660

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.290 0.113 0.0684 0.511
0.1 0.9160 1.26 0.305 0.139 0.0330 0.577
0.2 0.9110 1.58 0.315 0.138 0.0455 0.585
0.3 0.9090 2.00 0.315 0.140 0.0402 0.591
0.4 0.8870 2.51 0.319 0.140 0.0442 0.593
0.5 0.8860 3.16 0.325 0.138 0.0548 0.596
0.6 0.8690 3.98 0.325 0.143 0.0458 0.605
0.7 0.8580 5.01 0.347 0.141 0.0716 0.623
0.8 0.8570 6.31 0.360 0.140 0.0862 0.634
0.9 0.8480 7.94 0.361 0.142 0.0831 0.639
1.0 0.8200 10.00 0.375 0.137 0.1060 0.644
1.1 0.7670 12.60 0.375 0.141 0.0990 0.650
1.2 0.7380 15.80 0.388 0.139 0.1160 0.659
1.3 0.7020 20.00 0.400 0.138 0.1300 0.670
1.4 0.6650 25.10 0.400 0.145 0.1160 0.684
1.5 0.6210 31.60 0.418 0.143 0.1380 0.697
1.6 0.5750 39.80 0.469 0.136 0.2010 0.736
1.7 0.4890 50.10 0.469 0.144 0.1870 0.751
1.8 0.4480 63.10 0.475 0.147 0.1860 0.764
1.9 0.3790 79.40 0.504 0.152 0.2050 0.803
2.0 0.3170 100.00 0.543 0.152 0.2450 0.841
2.1 0.2760 126.00 0.543 0.160 0.2300 0.856
2.2 0.2270 158.00 0.545 0.174 0.2030 0.886
2.3 0.2010 200.00 0.545 0.196 0.1610 0.928
2.4 0.1610 251.00 0.545 0.199 0.1550 0.934
2.5 0.1300 316.00 0.545 0.197 0.1590 0.931
2.6 0.1020 398.00 0.545 0.207 0.1380 0.951
2.7 0.0838 501.00 0.545 0.245 0.0644 1.020
2.8 0.0584 631.00 0.545 0.446 -0.3300 1.420
2.9 0.0536 794.00 0.545 0.445 -0.3280 1.420
3.0 0.0428 1000.00 0.545 1.030 -1.4700 2.550
3.1 0.0327 1260.00 0.545 1.480 -2.3700 3.450
3.2 0.0307 1580.00 0.545 1.960 -3.3000 4.390
3.3 0.0304 2000.00 0.545 2.370 -4.1000 5.190

IgG3 V1V2 AE.A244-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00913 0.00104 7.09e-03 0.01120
0.1 0.9790 1.26 0.00913 0.00125 6.68e-03 0.01160
0.2 0.9780 1.58 0.00913 0.00126 6.66e-03 0.01160
0.3 0.9770 2.00 0.00913 0.00127 6.65e-03 0.01160
0.4 0.9760 2.51 0.00913 0.00127 6.63e-03 0.01160
0.5 0.9740 3.16 0.00913 0.00128 6.62e-03 0.01160
0.6 0.9710 3.98 0.00913 0.00128 6.63e-03 0.01160
0.7 0.9670 5.01 0.00913 0.00126 6.66e-03 0.01160
0.8 0.9640 6.31 0.00913 0.00128 6.62e-03 0.01160
0.9 0.9560 7.94 0.00913 0.00133 6.53e-03 0.01170
1.0 0.9500 10.00 0.00913 0.00134 6.49e-03 0.01180
1.1 0.9430 12.60 0.00913 0.00134 6.50e-03 0.01180
1.2 0.9390 15.80 0.00913 0.00135 6.48e-03 0.01180
1.3 0.9320 20.00 0.00913 0.00138 6.42e-03 0.01180
1.4 0.9220 25.10 0.00913 0.00145 6.28e-03 0.01200
1.5 0.9160 31.60 0.00913 0.00149 6.20e-03 0.01210
1.6 0.9110 39.80 0.00913 0.00150 6.19e-03 0.01210
1.7 0.9020 50.10 0.00904 0.00149 6.12e-03 0.01200
1.8 0.8880 63.10 0.00904 0.00159 5.93e-03 0.01210
1.9 0.8750 79.40 0.00894 0.00155 5.90e-03 0.01200
2.0 0.8630 100.00 0.00894 0.00159 5.83e-03 0.01210
2.1 0.8560 126.00 0.00894 0.00177 5.48e-03 0.01240
2.2 0.8390 158.00 0.00894 0.00201 5.01e-03 0.01290
2.3 0.8100 200.00 0.00894 0.00202 4.99e-03 0.01290
2.4 0.7710 251.00 0.00718 0.00177 3.72e-03 0.01060
2.5 0.7340 316.00 0.00690 0.00181 3.35e-03 0.01040
2.6 0.6760 398.00 0.00636 0.00169 3.04e-03 0.00967
2.7 0.6330 501.00 0.00542 0.00155 2.37e-03 0.00847
2.8 0.5810 631.00 0.00542 0.00169 2.10e-03 0.00873
2.9 0.5200 794.00 0.00542 0.00193 1.63e-03 0.00921
3.0 0.4340 1000.00 0.00542 0.00230 9.04e-04 0.00993
3.1 0.3580 1260.00 0.00542 0.00255 4.15e-04 0.01040
3.2 0.2990 1580.00 0.00542 0.00218 1.16e-03 0.00968
3.3 0.2440 2000.00 0.00542 0.00275 3.83e-05 0.01080
3.4 0.1820 2510.00 0.00542 0.00401 -2.45e-03 0.01330
3.5 0.1510 3160.00 0.00498 0.00200 1.07e-03 0.00889
3.6 0.1170 3980.00 0.00498 0.00238 3.12e-04 0.00965
3.7 0.0992 5010.00 0.00415 0.00247 -6.79e-04 0.00899

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00870 0.00104 0.006720 0.01150
0.1 1.26 0.9790 0.00913 0.00125 0.006680 0.01160
0.2 1.58 0.9780 0.00918 0.00126 0.006710 0.01160
0.3 2.00 0.9770 0.00923 0.00127 0.006750 0.01170
0.4 2.51 0.9760 0.00929 0.00127 0.006790 0.01180
0.5 3.16 0.9740 0.00925 0.00128 0.006740 0.01180
0.6 3.98 0.9710 0.00910 0.00128 0.006600 0.01160
0.7 5.01 0.9670 0.00888 0.00126 0.006410 0.01140
0.8 6.31 0.9640 0.00901 0.00128 0.006500 0.01150
0.9 7.94 0.9560 0.00931 0.00133 0.006710 0.01190
1.0 10.00 0.9500 0.00919 0.00134 0.006560 0.01180
1.1 12.60 0.9430 0.00892 0.00134 0.006300 0.01150
1.2 15.80 0.9390 0.00892 0.00135 0.006270 0.01160
1.3 20.00 0.9320 0.00907 0.00138 0.006360 0.01180
1.4 25.10 0.9220 0.00930 0.00145 0.006450 0.01220
1.5 31.60 0.9160 0.00953 0.00149 0.006600 0.01250
1.6 39.80 0.9110 0.00925 0.00150 0.006310 0.01220
1.7 50.10 0.9020 0.00890 0.00149 0.005980 0.01180
1.8 63.10 0.8880 0.00917 0.00159 0.006060 0.01230
1.9 79.40 0.8750 0.00851 0.00155 0.005470 0.01160
2.0 100.00 0.8630 0.00841 0.00159 0.005300 0.01150
2.1 126.00 0.8560 0.00905 0.00177 0.005580 0.01250
2.2 158.00 0.8390 0.00968 0.00201 0.005750 0.01360
2.3 200.00 0.8100 0.00913 0.00202 0.005170 0.01310
2.4 251.00 0.7710 0.00718 0.00177 0.003720 0.01060
2.5 316.00 0.7340 0.00690 0.00181 0.003350 0.01040
2.6 398.00 0.6760 0.00636 0.00169 0.003040 0.00967
2.7 501.00 0.6330 0.00534 0.00155 0.002290 0.00838
2.8 631.00 0.5810 0.00510 0.00169 0.001790 0.00842
2.9 794.00 0.5200 0.00557 0.00193 0.001780 0.00936
3.0 1000.00 0.4340 0.00570 0.00230 0.001190 0.01020
3.1 1260.00 0.3580 0.00543 0.00255 0.000430 0.01040
3.2 1580.00 0.2990 0.00505 0.00218 0.000782 0.00931
3.3 2000.00 0.2440 0.00646 0.00275 0.001080 0.01180
3.4 2510.00 0.1820 0.00930 0.00401 0.001440 0.01720
3.5 3160.00 0.1510 0.00480 0.00200 0.000885 0.00871
3.6 3980.00 0.1170 0.00517 0.00238 0.000497 0.00984
3.7 5010.00 0.0992 0.00415 0.00247 -0.000679 0.00899

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.254 0.115 0.028000 0.481
0.1 0.9790 1.26 0.254 0.129 0.001940 0.507
0.2 0.9780 1.58 0.254 0.129 0.001110 0.507
0.3 0.9770 2.00 0.254 0.130 0.000152 0.508
0.4 0.9760 2.51 0.254 0.130 -0.001060 0.510
0.5 0.9740 3.16 0.254 0.130 -0.001470 0.510
0.6 0.9710 3.98 0.254 0.130 -0.001160 0.510
0.7 0.9670 5.01 0.254 0.129 0.000543 0.508
0.8 0.9640 6.31 0.254 0.131 -0.001900 0.510
0.9 0.9560 7.94 0.254 0.134 -0.007850 0.516
1.0 0.9500 10.00 0.254 0.135 -0.010100 0.519
1.1 0.9430 12.60 0.254 0.135 -0.009360 0.518
1.2 0.9390 15.80 0.254 0.135 -0.011200 0.520
1.3 0.9320 20.00 0.254 0.137 -0.015200 0.524
1.4 0.9220 25.10 0.254 0.142 -0.024600 0.533
1.5 0.9160 31.60 0.254 0.145 -0.029900 0.539
1.6 0.9110 39.80 0.254 0.145 -0.030400 0.539
1.7 0.9020 50.10 0.262 0.144 -0.020700 0.545
1.8 0.8880 63.10 0.262 0.151 -0.034000 0.558
1.9 0.8750 79.40 0.269 0.148 -0.021200 0.560
2.0 0.8630 100.00 0.269 0.151 -0.025900 0.565
2.1 0.8560 126.00 0.269 0.163 -0.050800 0.590
2.2 0.8390 158.00 0.269 0.181 -0.085100 0.624
2.3 0.8100 200.00 0.269 0.182 -0.086800 0.626
2.4 0.7710 251.00 0.413 0.157 0.106000 0.721
2.5 0.7340 316.00 0.437 0.159 0.125000 0.749
2.6 0.6760 398.00 0.481 0.148 0.190000 0.772
2.7 0.6330 501.00 0.557 0.135 0.292000 0.822
2.8 0.5810 631.00 0.557 0.146 0.272000 0.843
2.9 0.5200 794.00 0.557 0.165 0.235000 0.880
3.0 0.4340 1000.00 0.557 0.194 0.178000 0.937
3.1 0.3580 1260.00 0.557 0.214 0.139000 0.976
3.2 0.2990 1580.00 0.557 0.184 0.197000 0.917
3.3 0.2440 2000.00 0.557 0.229 0.109000 1.010
3.4 0.1820 2510.00 0.557 0.331 -0.091600 1.210
3.5 0.1510 3160.00 0.593 0.169 0.263000 0.923
3.6 0.1170 3980.00 0.593 0.199 0.203000 0.984
3.7 0.0992 5010.00 0.661 0.205 0.260000 1.060

IgG3 V1V2 C.1086-Tags

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.00925 0.00104 0.007210 0.01130
0.1 0.971 1.26 0.00925 0.00129 0.006720 0.01180
0.2 0.970 1.58 0.00925 0.00128 0.006740 0.01180
0.3 0.970 2.00 0.00925 0.00128 0.006740 0.01180
0.4 0.968 2.51 0.00925 0.00129 0.006710 0.01180
0.5 0.963 3.16 0.00925 0.00130 0.006700 0.01180
0.6 0.962 3.98 0.00925 0.00130 0.006700 0.01180
0.7 0.956 5.01 0.00921 0.00130 0.006660 0.01180
0.8 0.947 6.31 0.00909 0.00129 0.006550 0.01160
0.9 0.935 7.94 0.00909 0.00133 0.006480 0.01170
1.0 0.927 10.00 0.00909 0.00137 0.006410 0.01180
1.1 0.916 12.60 0.00909 0.00140 0.006350 0.01180
1.2 0.903 15.80 0.00909 0.00141 0.006330 0.01180
1.3 0.897 20.00 0.00887 0.00142 0.006090 0.01160
1.4 0.887 25.10 0.00820 0.00138 0.005510 0.01090
1.5 0.873 31.60 0.00820 0.00141 0.005430 0.01100
1.6 0.856 39.80 0.00820 0.00147 0.005320 0.01110
1.7 0.840 50.10 0.00820 0.00151 0.005250 0.01120
1.8 0.804 63.10 0.00820 0.00162 0.005030 0.01140
1.9 0.772 79.40 0.00820 0.00168 0.004920 0.01150
2.0 0.704 100.00 0.00820 0.00178 0.004720 0.01170
2.1 0.652 126.00 0.00794 0.00174 0.004530 0.01140
2.2 0.601 158.00 0.00733 0.00182 0.003760 0.01090
2.3 0.560 200.00 0.00646 0.00171 0.003110 0.00981
2.4 0.500 251.00 0.00646 0.00184 0.002860 0.01010
2.5 0.424 316.00 0.00646 0.00196 0.002620 0.01030
2.6 0.341 398.00 0.00646 0.00242 0.001710 0.01120
2.7 0.297 501.00 0.00646 0.00268 0.001200 0.01170
2.8 0.228 631.00 0.00547 0.00213 0.001300 0.00963
2.9 0.175 794.00 0.00547 0.00247 0.000623 0.01030
3.0 0.159 1000.00 0.00547 0.00263 0.000311 0.01060
3.1 0.120 1260.00 0.00354 0.00214 -0.000658 0.00774

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.000 0.00870 0.00104 0.006720 0.01150
0.1 1.26 0.971 0.00946 0.00129 0.006930 0.01200
0.2 1.58 0.970 0.00926 0.00128 0.006750 0.01180
0.3 2.00 0.970 0.00926 0.00128 0.006750 0.01180
0.4 2.51 0.968 0.00935 0.00129 0.006810 0.01190
0.5 3.16 0.963 0.00941 0.00130 0.006860 0.01200
0.6 3.98 0.962 0.00933 0.00130 0.006780 0.01190
0.7 5.01 0.956 0.00921 0.00130 0.006660 0.01180
0.8 6.31 0.947 0.00889 0.00129 0.006350 0.01140
0.9 7.94 0.935 0.00905 0.00133 0.006440 0.01170
1.0 10.00 0.927 0.00919 0.00137 0.006510 0.01190
1.1 12.60 0.916 0.00923 0.00140 0.006490 0.01200
1.2 15.80 0.903 0.00910 0.00141 0.006340 0.01190
1.3 20.00 0.897 0.00887 0.00142 0.006090 0.01160
1.4 25.10 0.887 0.00808 0.00138 0.005380 0.01080
1.5 31.60 0.873 0.00806 0.00141 0.005290 0.01080
1.6 39.80 0.856 0.00822 0.00147 0.005330 0.01110
1.7 50.10 0.840 0.00813 0.00151 0.005180 0.01110
1.8 63.10 0.804 0.00826 0.00162 0.005090 0.01140
1.9 79.40 0.772 0.00810 0.00168 0.004820 0.01140
2.0 100.00 0.704 0.00863 0.00178 0.005150 0.01210
2.1 126.00 0.652 0.00794 0.00174 0.004530 0.01140
2.2 158.00 0.601 0.00733 0.00182 0.003760 0.01090
2.3 200.00 0.560 0.00641 0.00171 0.003060 0.00976
2.4 251.00 0.500 0.00628 0.00184 0.002670 0.00988
2.5 316.00 0.424 0.00593 0.00196 0.002080 0.00977
2.6 398.00 0.341 0.00673 0.00242 0.001980 0.01150
2.7 501.00 0.297 0.00714 0.00268 0.001880 0.01240
2.8 631.00 0.228 0.00475 0.00213 0.000578 0.00891
2.9 794.00 0.175 0.00545 0.00247 0.000606 0.01030
3.0 1000.00 0.159 0.00620 0.00263 0.001050 0.01140
3.1 1260.00 0.120 0.00354 0.00214 -0.000657 0.00774

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.000 1.00 0.245 0.116 0.017100 0.472
0.1 0.971 1.26 0.245 0.132 -0.013900 0.503
0.2 0.970 1.58 0.245 0.131 -0.012400 0.502
0.3 0.970 2.00 0.245 0.131 -0.012400 0.502
0.4 0.968 2.51 0.245 0.132 -0.014100 0.503
0.5 0.963 3.16 0.245 0.133 -0.015200 0.505
0.6 0.962 3.98 0.245 0.132 -0.014900 0.504
0.7 0.956 5.01 0.248 0.133 -0.012200 0.507
0.8 0.947 6.31 0.258 0.131 0.000177 0.515
0.9 0.935 7.94 0.258 0.134 -0.004600 0.520
1.0 0.927 10.00 0.258 0.136 -0.009130 0.524
1.1 0.916 12.60 0.258 0.138 -0.013400 0.529
1.2 0.903 15.80 0.258 0.139 -0.014400 0.530
1.3 0.897 20.00 0.276 0.138 0.004370 0.547
1.4 0.887 25.10 0.330 0.133 0.069900 0.590
1.5 0.873 31.60 0.330 0.135 0.064900 0.595
1.6 0.856 39.80 0.330 0.139 0.056600 0.603
1.7 0.840 50.10 0.330 0.142 0.052100 0.608
1.8 0.804 63.10 0.330 0.150 0.036400 0.623
1.9 0.772 79.40 0.330 0.154 0.028300 0.631
2.0 0.704 100.00 0.330 0.161 0.013700 0.646
2.1 0.652 126.00 0.352 0.158 0.042500 0.661
2.2 0.601 158.00 0.401 0.161 0.085200 0.718
2.3 0.560 200.00 0.472 0.150 0.178000 0.767
2.4 0.500 251.00 0.472 0.160 0.158000 0.786
2.5 0.424 316.00 0.472 0.170 0.140000 0.804
2.6 0.341 398.00 0.472 0.206 0.069200 0.875
2.7 0.297 501.00 0.472 0.226 0.028700 0.915
2.8 0.228 631.00 0.554 0.180 0.201000 0.906
2.9 0.175 794.00 0.554 0.207 0.148000 0.960
3.0 0.159 1000.00 0.554 0.220 0.123000 0.985
3.1 0.120 1260.00 0.711 0.178 0.363000 1.060

IgG3 V1V2 C.1086-gp70

Monotone

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.00870 0.00104 0.006660 0.0107
0.1 0.9660 1.26 0.00861 0.00123 0.006190 0.0110
0.2 0.9650 1.58 0.00861 0.00124 0.006180 0.0110
0.3 0.9650 2.00 0.00861 0.00124 0.006180 0.0110
0.4 0.9600 2.51 0.00861 0.00125 0.006170 0.0110
0.5 0.9580 3.16 0.00861 0.00125 0.006160 0.0111
0.6 0.9570 3.98 0.00852 0.00123 0.006120 0.0109
0.7 0.9510 5.01 0.00852 0.00124 0.006100 0.0109
0.8 0.9430 6.31 0.00852 0.00124 0.006090 0.0110
0.9 0.9400 7.94 0.00852 0.00126 0.006050 0.0110
1.0 0.9340 10.00 0.00852 0.00128 0.006020 0.0110
1.1 0.9250 12.60 0.00852 0.00130 0.005980 0.0111
1.2 0.9200 15.80 0.00846 0.00128 0.005960 0.0110
1.3 0.9170 20.00 0.00846 0.00127 0.005960 0.0110
1.4 0.9090 25.10 0.00846 0.00131 0.005900 0.0110
1.5 0.8860 31.60 0.00846 0.00129 0.005940 0.0110
1.6 0.8750 39.80 0.00846 0.00129 0.005940 0.0110
1.7 0.8520 50.10 0.00846 0.00132 0.005870 0.0111
1.8 0.8350 63.10 0.00846 0.00133 0.005860 0.0111
1.9 0.8310 79.40 0.00846 0.00138 0.005760 0.0112
2.0 0.8020 100.00 0.00846 0.00135 0.005820 0.0111
2.1 0.7610 126.00 0.00846 0.00140 0.005710 0.0112
2.2 0.7050 158.00 0.00846 0.00147 0.005580 0.0113
2.3 0.6510 200.00 0.00846 0.00155 0.005420 0.0115
2.4 0.6130 251.00 0.00846 0.00166 0.005200 0.0117
2.5 0.5550 316.00 0.00846 0.00182 0.004900 0.0120
2.6 0.4990 398.00 0.00846 0.00184 0.004850 0.0121
2.7 0.4260 501.00 0.00846 0.00211 0.004320 0.0126
2.8 0.3480 631.00 0.00846 0.00261 0.003350 0.0136
2.9 0.2870 794.00 0.00846 0.00288 0.002810 0.0141
3.0 0.2430 1000.00 0.00846 0.00326 0.002070 0.0149
3.1 0.2000 1260.00 0.00846 0.00319 0.002210 0.0147
3.2 0.1500 1580.00 0.00703 0.00287 0.001400 0.0127
3.3 0.1230 2000.00 0.00703 0.00352 0.000127 0.0139
3.4 0.0939 2510.00 0.00703 0.00453 -0.001840 0.0159
3.5 0.0695 3160.00 0.00703 0.00525 -0.003260 0.0173
3.6 0.0583 3980.00 0.00703 0.00477 -0.002320 0.0164
3.7 0.0421 5010.00 0.00703 0.00565 -0.004060 0.0181
3.8 0.0253 6310.00 0.00703 0.00904 -0.010700 0.0247

Not Monotone

Threshold (log10) Threshold rcdf Estimate SE Lower CI Upper CI
0.0 1.00 1.0000 0.00870 0.00104 6.72e-03 0.0115
0.1 1.26 0.9660 0.00858 0.00123 6.16e-03 0.0110
0.2 1.58 0.9650 0.00860 0.00124 6.17e-03 0.0110
0.3 2.00 0.9650 0.00860 0.00124 6.17e-03 0.0110
0.4 2.51 0.9600 0.00862 0.00125 6.18e-03 0.0111
0.5 3.16 0.9580 0.00865 0.00125 6.20e-03 0.0111
0.6 3.98 0.9570 0.00837 0.00123 5.97e-03 0.0108
0.7 5.01 0.9510 0.00844 0.00124 6.02e-03 0.0109
0.8 6.31 0.9430 0.00842 0.00124 5.98e-03 0.0108
0.9 7.94 0.9400 0.00855 0.00126 6.08e-03 0.0110
1.0 10.00 0.9340 0.00862 0.00128 6.12e-03 0.0111
1.1 12.60 0.9250 0.00875 0.00130 6.20e-03 0.0113
1.2 15.80 0.9200 0.00838 0.00128 5.88e-03 0.0109
1.3 20.00 0.9170 0.00821 0.00127 5.72e-03 0.0107
1.4 25.10 0.9090 0.00841 0.00131 5.85e-03 0.0110
1.5 31.60 0.8860 0.00811 0.00129 5.58e-03 0.0106
1.6 39.80 0.8750 0.00803 0.00129 5.51e-03 0.0106
1.7 50.10 0.8520 0.00816 0.00132 5.56e-03 0.0107
1.8 63.10 0.8350 0.00802 0.00133 5.42e-03 0.0106
1.9 79.40 0.8310 0.00829 0.00138 5.59e-03 0.0110
2.0 100.00 0.8020 0.00779 0.00135 5.15e-03 0.0104
2.1 126.00 0.7610 0.00799 0.00140 5.24e-03 0.0107
2.2 158.00 0.7050 0.00794 0.00147 5.05e-03 0.0108
2.3 200.00 0.6510 0.00809 0.00155 5.05e-03 0.0111
2.4 251.00 0.6130 0.00855 0.00166 5.29e-03 0.0118
2.5 316.00 0.5550 0.00909 0.00182 5.53e-03 0.0126
2.6 398.00 0.4990 0.00856 0.00184 4.95e-03 0.0122
2.7 501.00 0.4260 0.00870 0.00211 4.56e-03 0.0128
2.8 631.00 0.3480 0.01030 0.00261 5.15e-03 0.0154
2.9 794.00 0.2870 0.01020 0.00288 4.55e-03 0.0158
3.0 1000.00 0.2430 0.00943 0.00326 3.04e-03 0.0158
3.1 1260.00 0.2000 0.00933 0.00319 3.08e-03 0.0156
3.2 1580.00 0.1500 0.00647 0.00287 8.45e-04 0.0121
3.3 2000.00 0.1230 0.00758 0.00352 6.85e-04 0.0145
3.4 2510.00 0.0939 0.00890 0.00453 3.07e-05 0.0178
3.5 3160.00 0.0695 0.01130 0.00525 1.03e-03 0.0216
3.6 3980.00 0.0583 0.00945 0.00477 1.01e-04 0.0188
3.7 5010.00 0.0421 0.01020 0.00565 -8.55e-04 0.0213
3.8 6310.00 0.0253 0.01820 0.00904 4.83e-04 0.0359

Vaccine efficacy (monotone)

Threshold (log10) rcdf Threshold Estimate SE Lower CI Upper CI
0.0 1.0000 1.00 0.290 0.113 0.06840 0.511
0.1 0.9660 1.26 0.297 0.125 0.05200 0.542
0.2 0.9650 1.58 0.297 0.125 0.05160 0.542
0.3 0.9650 2.00 0.297 0.125 0.05160 0.542
0.4 0.9600 2.51 0.297 0.126 0.05060 0.543
0.5 0.9580 3.16 0.297 0.126 0.05010 0.544
0.6 0.9570 3.98 0.304 0.124 0.06050 0.547
0.7 0.9510 5.01 0.304 0.125 0.05940 0.548
0.8 0.9430 6.31 0.304 0.125 0.05870 0.549
0.9 0.9400 7.94 0.304 0.127 0.05570 0.552
1.0 0.9340 10.00 0.304 0.127 0.05400 0.553
1.1 0.9250 12.60 0.304 0.129 0.05110 0.556
1.2 0.9200 15.80 0.309 0.127 0.05970 0.558
1.3 0.9170 20.00 0.309 0.127 0.06000 0.557
1.4 0.9090 25.10 0.309 0.129 0.05590 0.562
1.5 0.8860 31.60 0.309 0.128 0.05810 0.559
1.6 0.8750 39.80 0.309 0.128 0.05840 0.559
1.7 0.8520 50.10 0.309 0.130 0.05360 0.564
1.8 0.8350 63.10 0.309 0.130 0.05320 0.564
1.9 0.8310 79.40 0.309 0.134 0.04630 0.571
2.0 0.8020 100.00 0.309 0.132 0.05000 0.568
2.1 0.7610 126.00 0.309 0.136 0.04290 0.575
2.2 0.7050 158.00 0.309 0.140 0.03350 0.584
2.3 0.6510 200.00 0.309 0.146 0.02220 0.595
2.4 0.6130 251.00 0.309 0.154 0.00689 0.611
2.5 0.5550 316.00 0.309 0.165 -0.01480 0.632
2.6 0.4990 398.00 0.309 0.167 -0.01850 0.636
2.7 0.4260 501.00 0.309 0.187 -0.05810 0.676
2.8 0.3480 631.00 0.309 0.225 -0.13200 0.750
2.9 0.2870 794.00 0.309 0.246 -0.17400 0.792
3.0 0.2430 1000.00 0.309 0.276 -0.23300 0.850
3.1 0.2000 1260.00 0.309 0.270 -0.22100 0.839
3.2 0.1500 1580.00 0.426 0.242 -0.04820 0.901
3.3 0.1230 2000.00 0.426 0.294 -0.15000 1.000
3.4 0.0939 2510.00 0.426 0.375 -0.30800 1.160
3.5 0.0695 3160.00 0.426 0.433 -0.42300 1.270
3.6 0.0583 3980.00 0.426 0.394 -0.34700 1.200
3.7 0.0421 5010.00 0.426 0.466 -0.48700 1.340
3.8 0.0253 6310.00 0.426 0.741 -1.03000 1.880