Threshold Analysis on HIV trials

Overview

• Threshold analysis run on four HIV vaccine trials: HVTN705, HVTN702, HVTN505, and RV144, as well as HVTN 705 + RV144 combined.
• Analyses run on vaccine participants only. (Marker variable values were missing or 0 for most placebo participants in each study.)
• Thresholds were selected over a grid of increments of 0.1, from the lowest marker value to the highest value of the marker such that there are at least 3 endpoints with a marker at least that value
• Reference timepoint was chosen as the timepoint of the latest endpoint
• For VE graphs, placebo risk was determined by using all data from the placebo arm, regardless of whether the marker was sampled. Note: For HVTN705, there are 210 placebo participants missing their event/censoring time variable. These are excluded when calculating the placebo risk.
• Vaccine efficacy confidence intervals cutoffs between -1 and 1.

HVTN 705

• Adjustment covariates: Age, RSA, BMI, Riskscore
• Event time variable: Ttilde.D210
• Event type variable: Delta.D210
• Weight variable: wt.D210
• Reference timepoint: 552 days
• Filter: !is.na(Ttilde.D210)
• All learners: GLM

IgG V1V2 B.CaseA-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.0515	0.00678	0.03820	0.0648
0.1	0.9030	1.26	0.0496	0.00777	0.03440	0.0648
0.2	0.9030	1.58	0.0496	0.00777	0.03440	0.0648
0.3	0.9030	2.00	0.0496	0.00777	0.03440	0.0648
0.4	0.9030	2.51	0.0496	0.00777	0.03440	0.0648
0.5	0.9030	3.16	0.0496	0.00777	0.03440	0.0648
0.6	0.9030	3.98	0.0496	0.00777	0.03440	0.0648
0.7	0.9030	5.01	0.0496	0.00777	0.03440	0.0648
0.8	0.9030	6.31	0.0496	0.00777	0.03440	0.0648
0.9	0.9030	7.94	0.0496	0.00777	0.03440	0.0648
1.0	0.9030	10.00	0.0496	0.00777	0.03440	0.0648
1.1	0.8980	12.60	0.0496	0.00782	0.03430	0.0649
1.2	0.8810	15.80	0.0496	0.00794	0.03400	0.0652
1.3	0.8810	20.00	0.0496	0.00794	0.03400	0.0652
1.4	0.8810	25.10	0.0496	0.00794	0.03400	0.0652
1.5	0.8700	31.60	0.0496	0.00803	0.03390	0.0653
1.6	0.8550	39.80	0.0496	0.00814	0.03360	0.0656
1.7	0.8280	50.10	0.0496	0.00815	0.03360	0.0656
1.8	0.8080	63.10	0.0496	0.00818	0.03360	0.0656
1.9	0.8040	79.40	0.0496	0.00813	0.03370	0.0655
2.0	0.7830	100.00	0.0496	0.00825	0.03340	0.0658
2.1	0.7690	126.00	0.0496	0.00825	0.03340	0.0658
2.2	0.7570	158.00	0.0496	0.00837	0.03320	0.0660
2.3	0.7350	200.00	0.0496	0.00853	0.03290	0.0663
2.4	0.7010	251.00	0.0496	0.00875	0.03240	0.0668
2.5	0.6830	316.00	0.0496	0.00879	0.03240	0.0668
2.6	0.6420	398.00	0.0496	0.00929	0.03140	0.0678
2.7	0.5890	501.00	0.0496	0.01020	0.02970	0.0695
2.8	0.5410	631.00	0.0496	0.01080	0.02840	0.0708
2.9	0.5110	794.00	0.0496	0.01090	0.02830	0.0709
3.0	0.4690	1000.00	0.0496	0.01110	0.02790	0.0713
3.1	0.4250	1260.00	0.0433	0.01090	0.02200	0.0646
3.2	0.4020	1580.00	0.0424	0.01050	0.02180	0.0631
3.3	0.3520	2000.00	0.0424	0.01170	0.01940	0.0655
3.4	0.3250	2510.00	0.0424	0.01130	0.02020	0.0647
3.5	0.2940	3160.00	0.0424	0.01280	0.01730	0.0676
3.6	0.2680	3980.00	0.0424	0.01440	0.01420	0.0707
3.7	0.2340	5010.00	0.0424	0.01500	0.01300	0.0719
3.8	0.2060	6310.00	0.0424	0.01580	0.01140	0.0735
3.9	0.1750	7940.00	0.0424	0.01510	0.01290	0.0720
4.0	0.1360	10000.00	0.0424	0.02220	-0.00115	0.0860
4.1	0.1190	12600.00	0.0424	0.02860	-0.01360	0.0985
4.2	0.0917	15800.00	0.0424	0.03270	-0.02160	0.1060
4.3	0.0722	20000.00	0.0348	0.02780	-0.01970	0.0892

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.0515	0.00678	0.03570	0.0650
0.1	1.26	0.9030	0.0490	0.00777	0.03380	0.0643
0.2	1.58	0.9030	0.0490	0.00777	0.03380	0.0643
0.3	2.00	0.9030	0.0490	0.00777	0.03380	0.0643
0.4	2.51	0.9030	0.0490	0.00777	0.03380	0.0643
0.5	3.16	0.9030	0.0490	0.00777	0.03380	0.0643
0.6	3.98	0.9030	0.0490	0.00777	0.03380	0.0643
0.7	5.01	0.9030	0.0490	0.00777	0.03380	0.0643
0.8	6.31	0.9030	0.0490	0.00777	0.03380	0.0643
0.9	7.94	0.9030	0.0490	0.00777	0.03380	0.0643
1.0	10.00	0.9030	0.0490	0.00777	0.03380	0.0643
1.1	12.60	0.8980	0.0493	0.00782	0.03400	0.0646
1.2	15.80	0.8810	0.0501	0.00794	0.03450	0.0656
1.3	20.00	0.8810	0.0501	0.00794	0.03450	0.0656
1.4	25.10	0.8810	0.0501	0.00794	0.03450	0.0656
1.5	31.60	0.8700	0.0506	0.00803	0.03480	0.0663
1.6	39.80	0.8550	0.0508	0.00814	0.03490	0.0668
1.7	50.10	0.8280	0.0499	0.00815	0.03390	0.0659
1.8	63.10	0.8080	0.0490	0.00818	0.03300	0.0651
1.9	79.40	0.8040	0.0482	0.00813	0.03220	0.0641
2.0	100.00	0.7830	0.0484	0.00825	0.03220	0.0646
2.1	126.00	0.7690	0.0477	0.00825	0.03150	0.0639
2.2	158.00	0.7570	0.0484	0.00837	0.03200	0.0648
2.3	200.00	0.7350	0.0486	0.00853	0.03180	0.0653
2.4	251.00	0.7010	0.0483	0.00875	0.03110	0.0654
2.5	316.00	0.6830	0.0478	0.00879	0.03060	0.0650
2.6	398.00	0.6420	0.0495	0.00929	0.03130	0.0677
2.7	501.00	0.5890	0.0535	0.01020	0.03360	0.0734
2.8	631.00	0.5410	0.0562	0.01080	0.03500	0.0775
2.9	794.00	0.5110	0.0533	0.01090	0.03200	0.0746
3.0	1000.00	0.4690	0.0501	0.01110	0.02840	0.0718
3.1	1260.00	0.4250	0.0433	0.01090	0.02200	0.0646
3.2	1580.00	0.4020	0.0410	0.01050	0.02040	0.0616
3.3	2000.00	0.3520	0.0425	0.01170	0.01950	0.0655
3.4	2510.00	0.3250	0.0381	0.01130	0.01580	0.0603
3.5	3160.00	0.2940	0.0429	0.01280	0.01780	0.0680
3.6	3980.00	0.2680	0.0461	0.01440	0.01780	0.0744
3.7	5010.00	0.2340	0.0450	0.01500	0.01550	0.0744
3.8	6310.00	0.2060	0.0427	0.01580	0.01170	0.0738
3.9	7940.00	0.1750	0.0325	0.01510	0.00291	0.0620
4.0	10000.00	0.1360	0.0451	0.02220	0.00149	0.0887
4.1	12600.00	0.1190	0.0511	0.02860	-0.00500	0.1070
4.2	15800.00	0.0917	0.0514	0.03270	-0.01260	0.1150
4.3	20000.00	0.0722	0.0348	0.02780	-0.01970	0.0892

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.122	0.157	-0.186	0.430
0.1	0.9030	1.26	0.155	0.168	-0.174	0.483
0.2	0.9030	1.58	0.155	0.168	-0.174	0.483
0.3	0.9030	2.00	0.155	0.168	-0.174	0.483
0.4	0.9030	2.51	0.155	0.168	-0.174	0.483
0.5	0.9030	3.16	0.155	0.168	-0.174	0.483
0.6	0.9030	3.98	0.155	0.168	-0.174	0.483
0.7	0.9030	5.01	0.155	0.168	-0.174	0.483
0.8	0.9030	6.31	0.155	0.168	-0.174	0.483
0.9	0.9030	7.94	0.155	0.168	-0.174	0.483
1.0	0.9030	10.00	0.155	0.168	-0.174	0.483
1.1	0.8980	12.60	0.155	0.168	-0.175	0.484
1.2	0.8810	15.80	0.155	0.170	-0.178	0.488
1.3	0.8810	20.00	0.155	0.170	-0.178	0.488
1.4	0.8810	25.10	0.155	0.170	-0.178	0.488
1.5	0.8700	31.60	0.155	0.171	-0.181	0.490
1.6	0.8550	39.80	0.155	0.173	-0.183	0.493
1.7	0.8280	50.10	0.155	0.173	-0.184	0.493
1.8	0.8080	63.10	0.155	0.173	-0.185	0.494
1.9	0.8040	79.40	0.155	0.172	-0.183	0.493
2.0	0.7830	100.00	0.155	0.174	-0.186	0.496
2.1	0.7690	126.00	0.155	0.174	-0.186	0.496
2.2	0.7570	158.00	0.155	0.176	-0.190	0.499
2.3	0.7350	200.00	0.155	0.178	-0.194	0.504
2.4	0.7010	251.00	0.155	0.181	-0.200	0.510
2.5	0.6830	316.00	0.155	0.182	-0.201	0.511
2.6	0.6420	398.00	0.155	0.189	-0.215	0.525
2.7	0.5890	501.00	0.155	0.201	-0.240	0.549
2.8	0.5410	631.00	0.155	0.211	-0.259	0.569
2.9	0.5110	794.00	0.155	0.212	-0.260	0.570
3.0	0.4690	1000.00	0.155	0.215	-0.266	0.575
3.1	0.4250	1260.00	0.262	0.206	-0.141	0.665
3.2	0.4020	1580.00	0.277	0.200	-0.115	0.668
3.3	0.3520	2000.00	0.277	0.219	-0.152	0.705
3.4	0.3250	2510.00	0.277	0.212	-0.140	0.693
3.5	0.2940	3160.00	0.277	0.236	-0.185	0.738
3.6	0.2680	3980.00	0.277	0.261	-0.235	0.788
3.7	0.2340	5010.00	0.277	0.271	-0.253	0.807
3.8	0.2060	6310.00	0.277	0.284	-0.280	0.833
3.9	0.1750	7940.00	0.277	0.272	-0.256	0.809
4.0	0.1360	10000.00	0.277	0.389	-0.486	1.040
4.1	0.1190	12600.00	0.277	0.495	-0.694	1.250
4.2	0.0917	15800.00	0.277	0.563	-0.827	1.380
4.3	0.0722	20000.00	0.408	0.479	-0.531	1.350

IgG V1V2 AE.A244-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.0515	0.00678	0.03820	0.0648
0.1	0.993	1.26	0.0511	0.00741	0.03660	0.0657
0.2	0.993	1.58	0.0511	0.00741	0.03660	0.0657
0.3	0.993	2.00	0.0511	0.00741	0.03660	0.0657
0.4	0.993	2.51	0.0511	0.00741	0.03660	0.0657
0.5	0.993	3.16	0.0511	0.00741	0.03660	0.0657
0.6	0.993	3.98	0.0511	0.00741	0.03660	0.0657
0.7	0.992	5.01	0.0511	0.00733	0.03680	0.0655
0.8	0.992	6.31	0.0511	0.00733	0.03680	0.0655
0.9	0.992	7.94	0.0511	0.00733	0.03680	0.0655
1.0	0.992	10.00	0.0511	0.00733	0.03680	0.0655
1.1	0.989	12.60	0.0511	0.00730	0.03680	0.0654
1.2	0.986	15.80	0.0511	0.00733	0.03680	0.0655
1.3	0.986	20.00	0.0511	0.00733	0.03680	0.0655
1.4	0.978	25.10	0.0511	0.00740	0.03660	0.0656
1.5	0.972	31.60	0.0511	0.00747	0.03650	0.0658
1.6	0.969	39.80	0.0511	0.00749	0.03640	0.0658
1.7	0.966	50.10	0.0511	0.00752	0.03640	0.0659
1.8	0.958	63.10	0.0511	0.00760	0.03620	0.0660
1.9	0.949	79.40	0.0511	0.00768	0.03610	0.0662
2.0	0.946	100.00	0.0511	0.00764	0.03620	0.0661
2.1	0.916	126.00	0.0511	0.00784	0.03580	0.0665
2.2	0.872	158.00	0.0511	0.00823	0.03500	0.0673
2.3	0.854	200.00	0.0511	0.00828	0.03490	0.0674
2.4	0.800	251.00	0.0511	0.00888	0.03370	0.0685
2.5	0.740	316.00	0.0511	0.00936	0.03280	0.0695
2.6	0.694	398.00	0.0511	0.00965	0.03220	0.0700
2.7	0.613	501.00	0.0511	0.01050	0.03050	0.0718
2.8	0.564	631.00	0.0511	0.01060	0.03040	0.0719
2.9	0.508	794.00	0.0511	0.01130	0.02910	0.0732
3.0	0.436	1000.00	0.0511	0.01270	0.02620	0.0761
3.1	0.351	1260.00	0.0511	0.01530	0.02120	0.0811
3.2	0.291	1580.00	0.0511	0.01670	0.01850	0.0838
3.3	0.239	2000.00	0.0511	0.01780	0.01620	0.0861
3.4	0.184	2510.00	0.0403	0.01570	0.00952	0.0710
3.5	0.154	3160.00	0.0353	0.01530	0.00519	0.0653
3.6	0.108	3980.00	0.0353	0.01870	-0.00130	0.0718

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.0515	0.00678	0.035700	0.0650
0.1	1.26	0.993	0.0495	0.00741	0.035000	0.0641
0.2	1.58	0.993	0.0495	0.00741	0.035000	0.0641
0.3	2.00	0.993	0.0495	0.00741	0.035000	0.0641
0.4	2.51	0.993	0.0495	0.00741	0.035000	0.0641
0.5	3.16	0.993	0.0495	0.00741	0.035000	0.0641
0.6	3.98	0.993	0.0495	0.00741	0.035000	0.0641
0.7	5.01	0.992	0.0486	0.00733	0.034200	0.0629
0.8	6.31	0.992	0.0486	0.00733	0.034200	0.0629
0.9	7.94	0.992	0.0486	0.00733	0.034200	0.0629
1.0	10.00	0.992	0.0486	0.00733	0.034200	0.0629
1.1	12.60	0.989	0.0480	0.00730	0.033700	0.0623
1.2	15.80	0.986	0.0482	0.00733	0.033800	0.0625
1.3	20.00	0.986	0.0482	0.00733	0.033800	0.0625
1.4	25.10	0.978	0.0486	0.00740	0.034100	0.0631
1.5	31.60	0.972	0.0490	0.00747	0.034400	0.0637
1.6	39.80	0.969	0.0492	0.00749	0.034500	0.0638
1.7	50.10	0.966	0.0493	0.00752	0.034600	0.0641
1.8	63.10	0.958	0.0498	0.00760	0.035000	0.0647
1.9	79.40	0.949	0.0503	0.00768	0.035300	0.0654
2.0	100.00	0.946	0.0495	0.00764	0.034600	0.0645
2.1	126.00	0.916	0.0503	0.00784	0.035000	0.0657
2.2	158.00	0.872	0.0516	0.00823	0.035500	0.0678
2.3	200.00	0.854	0.0514	0.00828	0.035200	0.0677
2.4	251.00	0.800	0.0548	0.00888	0.037400	0.0722
2.5	316.00	0.740	0.0564	0.00936	0.038100	0.0748
2.6	398.00	0.694	0.0546	0.00965	0.035600	0.0735
2.7	501.00	0.613	0.0564	0.01050	0.035700	0.0770
2.8	631.00	0.564	0.0534	0.01060	0.032700	0.0741
2.9	794.00	0.508	0.0537	0.01130	0.031600	0.0758
3.0	1000.00	0.436	0.0581	0.01270	0.033200	0.0831
3.1	1260.00	0.351	0.0672	0.01530	0.037300	0.0971
3.2	1580.00	0.291	0.0595	0.01670	0.026900	0.0922
3.3	2000.00	0.239	0.0584	0.01780	0.023400	0.0934
3.4	2510.00	0.184	0.0403	0.01570	0.009520	0.0710
3.5	3160.00	0.154	0.0335	0.01530	0.003450	0.0636
3.6	3980.00	0.108	0.0370	0.01870	0.000438	0.0736

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.122	0.157	-0.186	0.430
0.1	0.993	1.26	0.129	0.165	-0.194	0.452
0.2	0.993	1.58	0.129	0.165	-0.194	0.452
0.3	0.993	2.00	0.129	0.165	-0.194	0.452
0.4	0.993	2.51	0.129	0.165	-0.194	0.452
0.5	0.993	3.16	0.129	0.165	-0.194	0.452
0.6	0.993	3.98	0.129	0.165	-0.194	0.452
0.7	0.992	5.01	0.129	0.164	-0.192	0.450
0.8	0.992	6.31	0.129	0.164	-0.192	0.450
0.9	0.992	7.94	0.129	0.164	-0.192	0.450
1.0	0.992	10.00	0.129	0.164	-0.192	0.450
1.1	0.989	12.60	0.129	0.163	-0.191	0.449
1.2	0.986	15.80	0.129	0.164	-0.192	0.449
1.3	0.986	20.00	0.129	0.164	-0.192	0.449
1.4	0.978	25.10	0.129	0.165	-0.194	0.451
1.5	0.972	31.60	0.129	0.166	-0.196	0.453
1.6	0.969	39.80	0.129	0.166	-0.196	0.454
1.7	0.966	50.10	0.129	0.166	-0.197	0.454
1.8	0.958	63.10	0.129	0.167	-0.199	0.456
1.9	0.949	79.40	0.129	0.168	-0.201	0.459
2.0	0.946	100.00	0.129	0.168	-0.200	0.457
2.1	0.916	126.00	0.129	0.170	-0.205	0.463
2.2	0.872	158.00	0.129	0.176	-0.216	0.473
2.3	0.854	200.00	0.129	0.176	-0.217	0.474
2.4	0.800	251.00	0.129	0.185	-0.233	0.491
2.5	0.740	316.00	0.129	0.191	-0.246	0.504
2.6	0.694	398.00	0.129	0.196	-0.255	0.512
2.7	0.613	501.00	0.129	0.208	-0.280	0.537
2.8	0.564	631.00	0.129	0.209	-0.281	0.538
2.9	0.508	794.00	0.129	0.219	-0.301	0.558
3.0	0.436	1000.00	0.129	0.241	-0.344	0.601
3.1	0.351	1260.00	0.129	0.281	-0.422	0.679
3.2	0.291	1580.00	0.129	0.303	-0.465	0.723
3.3	0.239	2000.00	0.129	0.322	-0.502	0.760
3.4	0.184	2510.00	0.314	0.280	-0.235	0.863
3.5	0.154	3160.00	0.399	0.271	-0.133	0.931
3.6	0.108	3980.00	0.399	0.326	-0.240	1.040

IgG V1V2 C.1086-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.0515	0.00678	0.03820	0.0648
0.1	0.990	1.26	0.0514	0.00739	0.03690	0.0659
0.2	0.990	1.58	0.0514	0.00739	0.03690	0.0659
0.3	0.990	2.00	0.0514	0.00739	0.03690	0.0659
0.4	0.990	2.51	0.0514	0.00739	0.03690	0.0659
0.5	0.990	3.16	0.0514	0.00739	0.03690	0.0659
0.6	0.990	3.98	0.0514	0.00739	0.03690	0.0659
0.7	0.990	5.01	0.0514	0.00739	0.03690	0.0659
0.8	0.990	6.31	0.0514	0.00739	0.03690	0.0659
0.9	0.990	7.94	0.0514	0.00739	0.03690	0.0659
1.0	0.989	10.00	0.0514	0.00731	0.03710	0.0657
1.1	0.988	12.60	0.0514	0.00723	0.03720	0.0656
1.2	0.982	15.80	0.0514	0.00730	0.03710	0.0657
1.3	0.976	20.00	0.0514	0.00736	0.03700	0.0658
1.4	0.975	25.10	0.0514	0.00728	0.03710	0.0657
1.5	0.956	31.60	0.0514	0.00737	0.03700	0.0659
1.6	0.933	39.80	0.0514	0.00761	0.03650	0.0663
1.7	0.926	50.10	0.0514	0.00760	0.03650	0.0663
1.8	0.903	63.10	0.0514	0.00767	0.03640	0.0664
1.9	0.888	79.40	0.0514	0.00780	0.03610	0.0667
2.0	0.865	100.00	0.0514	0.00794	0.03590	0.0670
2.1	0.817	126.00	0.0514	0.00872	0.03430	0.0685
2.2	0.745	158.00	0.0514	0.00939	0.03300	0.0698
2.3	0.709	200.00	0.0514	0.00976	0.03230	0.0705
2.4	0.655	251.00	0.0514	0.01060	0.03070	0.0721
2.5	0.584	316.00	0.0514	0.01100	0.02980	0.0730
2.6	0.537	398.00	0.0514	0.01080	0.03030	0.0725
2.7	0.454	501.00	0.0514	0.01270	0.02650	0.0764
2.8	0.363	631.00	0.0514	0.01420	0.02350	0.0793
2.9	0.314	794.00	0.0514	0.01430	0.02340	0.0794
3.0	0.270	1000.00	0.0514	0.01680	0.01840	0.0844
3.1	0.205	1260.00	0.0514	0.02010	0.01200	0.0909
3.2	0.166	1580.00	0.0405	0.01650	0.00812	0.0729

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.0515	0.00678	0.03570	0.0650
0.1	1.26	0.990	0.0490	0.00739	0.03450	0.0635
0.2	1.58	0.990	0.0490	0.00739	0.03450	0.0635
0.3	2.00	0.990	0.0490	0.00739	0.03450	0.0635
0.4	2.51	0.990	0.0490	0.00739	0.03450	0.0635
0.5	3.16	0.990	0.0490	0.00739	0.03450	0.0635
0.6	3.98	0.990	0.0490	0.00739	0.03450	0.0635
0.7	5.01	0.990	0.0490	0.00739	0.03450	0.0635
0.8	6.31	0.990	0.0490	0.00739	0.03450	0.0635
0.9	7.94	0.990	0.0490	0.00739	0.03450	0.0635
1.0	10.00	0.989	0.0480	0.00731	0.03370	0.0623
1.1	12.60	0.988	0.0471	0.00723	0.03290	0.0613
1.2	15.80	0.982	0.0475	0.00730	0.03320	0.0618
1.3	20.00	0.976	0.0479	0.00736	0.03350	0.0623
1.4	25.10	0.975	0.0470	0.00728	0.03270	0.0613
1.5	31.60	0.956	0.0476	0.00737	0.03310	0.0620
1.6	39.80	0.933	0.0490	0.00761	0.03410	0.0640
1.7	50.10	0.926	0.0485	0.00760	0.03360	0.0634
1.8	63.10	0.903	0.0484	0.00767	0.03340	0.0634
1.9	79.40	0.888	0.0492	0.00780	0.03390	0.0645
2.0	100.00	0.865	0.0495	0.00794	0.03390	0.0651
2.1	126.00	0.817	0.0542	0.00872	0.03710	0.0712
2.2	158.00	0.745	0.0568	0.00939	0.03840	0.0752
2.3	200.00	0.709	0.0575	0.00976	0.03830	0.0766
2.4	251.00	0.655	0.0612	0.01060	0.04050	0.0819
2.5	316.00	0.584	0.0603	0.01100	0.03880	0.0819
2.6	398.00	0.537	0.0545	0.01080	0.03340	0.0756
2.7	501.00	0.454	0.0623	0.01270	0.03730	0.0872
2.8	631.00	0.363	0.0603	0.01420	0.03240	0.0882
2.9	794.00	0.314	0.0545	0.01430	0.02650	0.0826
3.0	1000.00	0.270	0.0589	0.01680	0.02590	0.0919
3.1	1260.00	0.205	0.0703	0.02010	0.03080	0.1100
3.2	1580.00	0.166	0.0405	0.01650	0.00812	0.0729

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.122	0.157	-0.186	0.430
0.1	0.990	1.26	0.124	0.165	-0.199	0.447
0.2	0.990	1.58	0.124	0.165	-0.199	0.447
0.3	0.990	2.00	0.124	0.165	-0.199	0.447
0.4	0.990	2.51	0.124	0.165	-0.199	0.447
0.5	0.990	3.16	0.124	0.165	-0.199	0.447
0.6	0.990	3.98	0.124	0.165	-0.199	0.447
0.7	0.990	5.01	0.124	0.165	-0.199	0.447
0.8	0.990	6.31	0.124	0.165	-0.199	0.447
0.9	0.990	7.94	0.124	0.165	-0.199	0.447
1.0	0.989	10.00	0.124	0.164	-0.197	0.445
1.1	0.988	12.60	0.124	0.163	-0.195	0.443
1.2	0.982	15.80	0.124	0.164	-0.197	0.445
1.3	0.976	20.00	0.124	0.164	-0.198	0.446
1.4	0.975	25.10	0.124	0.163	-0.197	0.444
1.5	0.956	31.60	0.124	0.165	-0.199	0.447
1.6	0.933	39.80	0.124	0.168	-0.205	0.453
1.7	0.926	50.10	0.124	0.168	-0.205	0.452
1.8	0.903	63.10	0.124	0.168	-0.206	0.454
1.9	0.888	79.40	0.124	0.170	-0.210	0.457
2.0	0.865	100.00	0.124	0.172	-0.214	0.461
2.1	0.817	126.00	0.124	0.183	-0.234	0.482
2.2	0.745	158.00	0.124	0.192	-0.253	0.500
2.3	0.709	200.00	0.124	0.197	-0.263	0.511
2.4	0.655	251.00	0.124	0.209	-0.286	0.533
2.5	0.584	316.00	0.124	0.216	-0.299	0.547
2.6	0.537	398.00	0.124	0.212	-0.292	0.540
2.7	0.454	501.00	0.124	0.242	-0.350	0.597
2.8	0.363	631.00	0.124	0.265	-0.395	0.643
2.9	0.314	794.00	0.124	0.266	-0.397	0.645
3.0	0.270	1000.00	0.124	0.306	-0.476	0.723
3.1	0.205	1260.00	0.124	0.359	-0.580	0.828
3.2	0.166	1580.00	0.310	0.294	-0.266	0.886

IgG V1V2 C.1086-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.0515	0.00678	0.03820	0.0648
0.1	0.974	1.26	0.0514	0.00761	0.03650	0.0663
0.2	0.974	1.58	0.0514	0.00761	0.03650	0.0663
0.3	0.974	2.00	0.0514	0.00761	0.03650	0.0663
0.4	0.974	2.51	0.0514	0.00761	0.03650	0.0663
0.5	0.974	3.16	0.0514	0.00761	0.03650	0.0663
0.6	0.974	3.98	0.0514	0.00761	0.03650	0.0663
0.7	0.974	5.01	0.0514	0.00761	0.03650	0.0663
0.8	0.974	6.31	0.0514	0.00761	0.03650	0.0663
0.9	0.974	7.94	0.0514	0.00761	0.03650	0.0663
1.0	0.974	10.00	0.0514	0.00761	0.03650	0.0663
1.1	0.973	12.60	0.0514	0.00752	0.03670	0.0661
1.2	0.973	15.80	0.0514	0.00752	0.03670	0.0661
1.3	0.973	20.00	0.0514	0.00752	0.03670	0.0661
1.4	0.970	25.10	0.0514	0.00754	0.03660	0.0662
1.5	0.970	31.60	0.0514	0.00754	0.03660	0.0662
1.6	0.970	39.80	0.0514	0.00754	0.03660	0.0662
1.7	0.964	50.10	0.0514	0.00749	0.03670	0.0661
1.8	0.961	63.10	0.0514	0.00753	0.03660	0.0662
1.9	0.961	79.40	0.0514	0.00753	0.03660	0.0662
2.0	0.958	100.00	0.0514	0.00756	0.03660	0.0662
2.1	0.952	126.00	0.0514	0.00761	0.03650	0.0663
2.2	0.949	158.00	0.0514	0.00764	0.03640	0.0664
2.3	0.944	200.00	0.0514	0.00769	0.03630	0.0665
2.4	0.941	251.00	0.0514	0.00772	0.03630	0.0665
2.5	0.920	316.00	0.0514	0.00778	0.03620	0.0666
2.6	0.909	398.00	0.0514	0.00792	0.03590	0.0669
2.7	0.894	501.00	0.0514	0.00799	0.03570	0.0671
2.8	0.859	631.00	0.0514	0.00843	0.03490	0.0679
2.9	0.818	794.00	0.0514	0.00861	0.03450	0.0683
3.0	0.787	1000.00	0.0514	0.00872	0.03430	0.0685
3.1	0.756	1260.00	0.0514	0.00898	0.03380	0.0690
3.2	0.725	1580.00	0.0514	0.00907	0.03360	0.0692
3.3	0.675	2000.00	0.0514	0.00947	0.03280	0.0700
3.4	0.621	2510.00	0.0514	0.00993	0.03190	0.0709
3.5	0.566	3160.00	0.0514	0.01040	0.03100	0.0718
3.6	0.490	3980.00	0.0514	0.01160	0.02870	0.0741
3.7	0.436	5010.00	0.0514	0.01160	0.02870	0.0741
3.8	0.390	6310.00	0.0514	0.01180	0.02820	0.0746
3.9	0.330	7940.00	0.0514	0.01320	0.02550	0.0773
4.0	0.286	10000.00	0.0514	0.01610	0.01980	0.0830
4.1	0.235	12600.00	0.0514	0.01650	0.01900	0.0838
4.2	0.191	15800.00	0.0467	0.01760	0.01220	0.0812
4.3	0.150	20000.00	0.0467	0.02020	0.00711	0.0863

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.0515	0.00678	0.03570	0.0650
0.1	1.26	0.974	0.0509	0.00761	0.03600	0.0658
0.2	1.58	0.974	0.0509	0.00761	0.03600	0.0658
0.3	2.00	0.974	0.0509	0.00761	0.03600	0.0658
0.4	2.51	0.974	0.0509	0.00761	0.03600	0.0658
0.5	3.16	0.974	0.0509	0.00761	0.03600	0.0658
0.6	3.98	0.974	0.0509	0.00761	0.03600	0.0658
0.7	5.01	0.974	0.0509	0.00761	0.03600	0.0658
0.8	6.31	0.974	0.0509	0.00761	0.03600	0.0658
0.9	7.94	0.974	0.0509	0.00761	0.03600	0.0658
1.0	10.00	0.974	0.0509	0.00761	0.03600	0.0658
1.1	12.60	0.973	0.0498	0.00752	0.03510	0.0646
1.2	15.80	0.973	0.0498	0.00752	0.03510	0.0646
1.3	20.00	0.973	0.0498	0.00752	0.03510	0.0646
1.4	25.10	0.970	0.0500	0.00754	0.03520	0.0648
1.5	31.60	0.970	0.0500	0.00754	0.03520	0.0648
1.6	39.80	0.970	0.0500	0.00754	0.03520	0.0648
1.7	50.10	0.964	0.0493	0.00749	0.03460	0.0639
1.8	63.10	0.961	0.0495	0.00753	0.03480	0.0643
1.9	79.40	0.961	0.0495	0.00753	0.03480	0.0643
2.0	100.00	0.958	0.0497	0.00756	0.03490	0.0645
2.1	126.00	0.952	0.0501	0.00761	0.03520	0.0650
2.2	158.00	0.949	0.0503	0.00764	0.03530	0.0653
2.3	200.00	0.944	0.0506	0.00769	0.03550	0.0657
2.4	251.00	0.941	0.0508	0.00772	0.03560	0.0659
2.5	316.00	0.920	0.0506	0.00778	0.03530	0.0658
2.6	398.00	0.909	0.0515	0.00792	0.03600	0.0670
2.7	501.00	0.894	0.0514	0.00799	0.03570	0.0670
2.8	631.00	0.859	0.0542	0.00843	0.03770	0.0707
2.9	794.00	0.818	0.0541	0.00861	0.03720	0.0710
3.0	1000.00	0.787	0.0529	0.00872	0.03580	0.0700
3.1	1260.00	0.756	0.0539	0.00898	0.03630	0.0715
3.2	1580.00	0.725	0.0524	0.00907	0.03460	0.0702
3.3	2000.00	0.675	0.0532	0.00947	0.03460	0.0717
3.4	2510.00	0.621	0.0529	0.00993	0.03340	0.0723
3.5	3160.00	0.566	0.0542	0.01040	0.03380	0.0746
3.6	3980.00	0.490	0.0581	0.01160	0.03540	0.0808
3.7	5010.00	0.436	0.0537	0.01160	0.03100	0.0764
3.8	6310.00	0.390	0.0501	0.01180	0.02690	0.0732
3.9	7940.00	0.330	0.0518	0.01320	0.02590	0.0777
4.0	10000.00	0.286	0.0612	0.01610	0.02970	0.0928
4.1	12600.00	0.235	0.0515	0.01650	0.01910	0.0839
4.2	15800.00	0.191	0.0443	0.01760	0.00982	0.0788
4.3	20000.00	0.150	0.0491	0.02020	0.00953	0.0888

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.122	0.157	-0.186	0.430
0.1	0.974	1.26	0.124	0.168	-0.205	0.453
0.2	0.974	1.58	0.124	0.168	-0.205	0.453
0.3	0.974	2.00	0.124	0.168	-0.205	0.453
0.4	0.974	2.51	0.124	0.168	-0.205	0.453
0.5	0.974	3.16	0.124	0.168	-0.205	0.453
0.6	0.974	3.98	0.124	0.168	-0.205	0.453
0.7	0.974	5.01	0.124	0.168	-0.205	0.453
0.8	0.974	6.31	0.124	0.168	-0.205	0.453
0.9	0.974	7.94	0.124	0.168	-0.205	0.453
1.0	0.974	10.00	0.124	0.168	-0.205	0.453
1.1	0.973	12.60	0.124	0.166	-0.202	0.450
1.2	0.973	15.80	0.124	0.166	-0.202	0.450
1.3	0.973	20.00	0.124	0.166	-0.202	0.450
1.4	0.970	25.10	0.124	0.167	-0.203	0.451
1.5	0.970	31.60	0.124	0.167	-0.203	0.451
1.6	0.970	39.80	0.124	0.167	-0.203	0.451
1.7	0.964	50.10	0.124	0.166	-0.201	0.450
1.8	0.961	63.10	0.124	0.167	-0.203	0.451
1.9	0.961	79.40	0.124	0.167	-0.203	0.451
2.0	0.958	100.00	0.124	0.167	-0.203	0.452
2.1	0.952	126.00	0.124	0.168	-0.205	0.453
2.2	0.949	158.00	0.124	0.168	-0.205	0.454
2.3	0.944	200.00	0.124	0.169	-0.207	0.455
2.4	0.941	251.00	0.124	0.169	-0.207	0.456
2.5	0.920	316.00	0.124	0.170	-0.209	0.457
2.6	0.909	398.00	0.124	0.172	-0.213	0.461
2.7	0.894	501.00	0.124	0.173	-0.214	0.463
2.8	0.859	631.00	0.124	0.179	-0.226	0.474
2.9	0.818	794.00	0.124	0.181	-0.231	0.479
3.0	0.787	1000.00	0.124	0.183	-0.234	0.482
3.1	0.756	1260.00	0.124	0.186	-0.241	0.489
3.2	0.725	1580.00	0.124	0.188	-0.244	0.492
3.3	0.675	2000.00	0.124	0.193	-0.255	0.503
3.4	0.621	2510.00	0.124	0.200	-0.268	0.516
3.5	0.566	3160.00	0.124	0.207	-0.281	0.529
3.6	0.490	3980.00	0.124	0.224	-0.316	0.564
3.7	0.436	5010.00	0.124	0.224	-0.315	0.563
3.8	0.390	6310.00	0.124	0.228	-0.322	0.571
3.9	0.330	7940.00	0.124	0.249	-0.364	0.612
4.0	0.286	10000.00	0.124	0.294	-0.453	0.701
4.1	0.235	12600.00	0.124	0.301	-0.466	0.715
4.2	0.191	15800.00	0.204	0.315	-0.414	0.821
4.3	0.150	20000.00	0.204	0.358	-0.497	0.905

IgG3 V1V2 B.CaseA-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.0515	0.00678	0.03820	0.0648
0.1	0.5320	1.26	0.0496	0.01020	0.02960	0.0697
0.2	0.5230	1.58	0.0493	0.01020	0.02940	0.0692
0.3	0.5060	2.00	0.0493	0.01050	0.02870	0.0700
0.4	0.4910	2.51	0.0487	0.01040	0.02830	0.0691
0.5	0.4840	3.16	0.0469	0.01000	0.02730	0.0665
0.6	0.4610	3.98	0.0469	0.01040	0.02650	0.0673
0.7	0.4510	5.01	0.0455	0.01030	0.02530	0.0656
0.8	0.4420	6.31	0.0451	0.01030	0.02490	0.0652
0.9	0.4330	7.94	0.0451	0.01060	0.02440	0.0658
1.0	0.4270	10.00	0.0451	0.01040	0.02480	0.0654
1.1	0.3980	12.60	0.0451	0.01120	0.02310	0.0671
1.2	0.3890	15.80	0.0451	0.01100	0.02350	0.0666
1.3	0.3670	20.00	0.0451	0.01140	0.02280	0.0674
1.4	0.3420	25.10	0.0451	0.01260	0.02040	0.0697
1.5	0.3350	31.60	0.0436	0.01200	0.02010	0.0671
1.6	0.3190	39.80	0.0436	0.01220	0.01980	0.0675
1.7	0.3050	50.10	0.0436	0.01330	0.01750	0.0698
1.8	0.2740	63.10	0.0436	0.01400	0.01620	0.0710
1.9	0.2430	79.40	0.0436	0.01580	0.01270	0.0746
2.0	0.2340	100.00	0.0436	0.01610	0.01200	0.0752
2.1	0.2190	126.00	0.0436	0.01770	0.00890	0.0783
2.2	0.1910	158.00	0.0436	0.01550	0.01330	0.0739
2.3	0.1680	200.00	0.0436	0.01760	0.00908	0.0782
2.4	0.1510	251.00	0.0436	0.01870	0.00696	0.0803
2.5	0.1140	316.00	0.0436	0.02450	-0.00447	0.0917
2.6	0.1060	398.00	0.0436	0.02840	-0.01200	0.0992
2.7	0.0932	501.00	0.0436	0.06170	-0.07730	0.1650

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.0515	0.00678	3.57e-02	0.0650
0.1	1.26	0.5320	0.0496	0.01020	2.96e-02	0.0697
0.2	1.58	0.5230	0.0485	0.01020	2.86e-02	0.0684
0.3	2.00	0.5060	0.0501	0.01050	2.95e-02	0.0708
0.4	2.51	0.4910	0.0487	0.01040	2.83e-02	0.0691
0.5	3.16	0.4840	0.0460	0.01000	2.64e-02	0.0656
0.6	3.98	0.4610	0.0478	0.01040	2.75e-02	0.0682
0.7	5.01	0.4510	0.0455	0.01030	2.53e-02	0.0656
0.8	6.31	0.4420	0.0445	0.01030	2.43e-02	0.0646
0.9	7.94	0.4330	0.0457	0.01060	2.50e-02	0.0664
1.0	10.00	0.4270	0.0437	0.01040	2.34e-02	0.0641
1.1	12.60	0.3980	0.0464	0.01120	2.44e-02	0.0684
1.2	15.80	0.3890	0.0442	0.01100	2.27e-02	0.0658
1.3	20.00	0.3670	0.0434	0.01140	2.11e-02	0.0657
1.4	25.10	0.3420	0.0477	0.01260	2.31e-02	0.0724
1.5	31.60	0.3350	0.0426	0.01200	1.91e-02	0.0660
1.6	39.80	0.3190	0.0403	0.01220	1.65e-02	0.0642
1.7	50.10	0.3050	0.0440	0.01330	1.79e-02	0.0702
1.8	63.10	0.2740	0.0437	0.01400	1.63e-02	0.0711
1.9	79.40	0.2430	0.0480	0.01580	1.71e-02	0.0790
2.0	100.00	0.2340	0.0469	0.01610	1.53e-02	0.0785
2.1	126.00	0.2190	0.0486	0.01770	1.39e-02	0.0833
2.2	158.00	0.1910	0.0346	0.01550	4.31e-03	0.0649
2.3	200.00	0.1680	0.0391	0.01760	4.54e-03	0.0736
2.4	251.00	0.1510	0.0367	0.01870	4.15e-05	0.0734
2.5	316.00	0.1140	0.0398	0.02450	-8.27e-03	0.0879
2.6	398.00	0.1060	0.0438	0.02840	-1.18e-02	0.0994
2.7	501.00	0.0932	0.0758	0.06170	-4.51e-02	0.1970

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.122	0.157	-0.186	0.430
0.1	0.5320	1.26	0.154	0.202	-0.242	0.550
0.2	0.5230	1.58	0.160	0.201	-0.234	0.554
0.3	0.5060	2.00	0.160	0.206	-0.245	0.565
0.4	0.4910	2.51	0.170	0.204	-0.229	0.570
0.5	0.4840	3.16	0.201	0.196	-0.184	0.585
0.6	0.4610	3.98	0.201	0.202	-0.196	0.597
0.7	0.4510	5.01	0.225	0.199	-0.165	0.615
0.8	0.4420	6.31	0.232	0.199	-0.157	0.621
0.9	0.4330	7.94	0.232	0.203	-0.166	0.629
1.0	0.4270	10.00	0.232	0.200	-0.160	0.623
1.1	0.3980	12.60	0.232	0.213	-0.186	0.649
1.2	0.3890	15.80	0.232	0.209	-0.178	0.642
1.3	0.3670	20.00	0.232	0.215	-0.190	0.654
1.4	0.3420	25.10	0.232	0.234	-0.226	0.690
1.5	0.3350	31.60	0.257	0.223	-0.181	0.694
1.6	0.3190	39.80	0.257	0.226	-0.186	0.700
1.7	0.3050	50.10	0.257	0.245	-0.223	0.736
1.8	0.2740	63.10	0.257	0.255	-0.243	0.756
1.9	0.2430	79.40	0.257	0.284	-0.300	0.813
2.0	0.2340	100.00	0.257	0.289	-0.310	0.824
2.1	0.2190	126.00	0.257	0.315	-0.361	0.874
2.2	0.1910	158.00	0.257	0.279	-0.289	0.803
2.3	0.1680	200.00	0.257	0.314	-0.358	0.871
2.4	0.1510	251.00	0.257	0.331	-0.393	0.906
2.5	0.1140	316.00	0.257	0.428	-0.582	1.100
2.6	0.1060	398.00	0.257	0.492	-0.707	1.220
2.7	0.0932	501.00	0.257	1.060	-1.810	2.330

IgG3 V1V2 AE.A244-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.0535	0.00678	0.04020	0.0668
0.1	0.9160	1.26	0.0535	0.00786	0.03810	0.0689
0.2	0.9110	1.58	0.0535	0.00789	0.03810	0.0690
0.3	0.9020	2.00	0.0535	0.00798	0.03790	0.0692
0.4	0.8940	2.51	0.0535	0.00810	0.03770	0.0694
0.5	0.8790	3.16	0.0535	0.00813	0.03760	0.0694
0.6	0.8580	3.98	0.0535	0.00813	0.03760	0.0695
0.7	0.8420	5.01	0.0535	0.00805	0.03770	0.0693
0.8	0.8280	6.31	0.0535	0.00822	0.03740	0.0696
0.9	0.7940	7.94	0.0535	0.00866	0.03650	0.0705
1.0	0.7490	10.00	0.0535	0.00882	0.03620	0.0708
1.1	0.7100	12.60	0.0535	0.00886	0.03620	0.0709
1.2	0.6870	15.80	0.0535	0.00912	0.03560	0.0714
1.3	0.6680	20.00	0.0535	0.00942	0.03510	0.0720
1.4	0.6080	25.10	0.0535	0.00998	0.03400	0.0731
1.5	0.5860	31.60	0.0535	0.01020	0.03360	0.0735
1.6	0.5500	39.80	0.0535	0.01020	0.03350	0.0736
1.7	0.5220	50.10	0.0535	0.01040	0.03320	0.0738
1.8	0.4730	63.10	0.0535	0.01130	0.03130	0.0757
1.9	0.4310	79.40	0.0535	0.01150	0.03110	0.0760
2.0	0.4060	100.00	0.0535	0.01190	0.03010	0.0769
2.1	0.3560	126.00	0.0535	0.01400	0.02600	0.0810
2.2	0.3050	158.00	0.0535	0.01550	0.02310	0.0839
2.3	0.2650	200.00	0.0535	0.01610	0.02190	0.0851
2.4	0.2450	251.00	0.0395	0.01340	0.01330	0.0657
2.5	0.2140	316.00	0.0395	0.01510	0.00993	0.0690
2.6	0.1880	398.00	0.0395	0.01590	0.00841	0.0706
2.7	0.1690	501.00	0.0367	0.01650	0.00439	0.0691
2.8	0.1350	631.00	0.0317	0.01490	0.00245	0.0609
2.9	0.1160	794.00	0.0315	0.01550	0.00111	0.0619
3.0	0.0861	1000.00	0.0315	0.02130	-0.01010	0.0732

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.0515	0.00678	0.03570	0.0650
0.1	1.26	0.9160	0.0516	0.00786	0.03620	0.0670
0.2	1.58	0.9110	0.0518	0.00789	0.03640	0.0673
0.3	2.00	0.9020	0.0524	0.00798	0.03670	0.0680
0.4	2.51	0.8940	0.0532	0.00810	0.03730	0.0690
0.5	3.16	0.8790	0.0528	0.00813	0.03690	0.0687
0.6	3.98	0.8580	0.0518	0.00813	0.03590	0.0677
0.7	5.01	0.8420	0.0502	0.00805	0.03440	0.0660
0.8	6.31	0.8280	0.0513	0.00822	0.03520	0.0674
0.9	7.94	0.7940	0.0539	0.00866	0.03700	0.0709
1.0	10.00	0.7490	0.0531	0.00882	0.03580	0.0703
1.1	12.60	0.7100	0.0513	0.00886	0.03390	0.0686
1.2	15.80	0.6870	0.0520	0.00912	0.03410	0.0699
1.3	20.00	0.6680	0.0536	0.00942	0.03510	0.0720
1.4	25.10	0.6080	0.0552	0.00998	0.03570	0.0748
1.5	31.60	0.5860	0.0564	0.01020	0.03640	0.0763
1.6	39.80	0.5500	0.0540	0.01020	0.03400	0.0740
1.7	50.10	0.5220	0.0522	0.01040	0.03190	0.0725
1.8	63.10	0.4730	0.0557	0.01130	0.03350	0.0779
1.9	79.40	0.4310	0.0523	0.01150	0.02980	0.0747
2.0	100.00	0.4060	0.0529	0.01190	0.02950	0.0763
2.1	126.00	0.3560	0.0609	0.01400	0.03340	0.0883
2.2	158.00	0.3050	0.0636	0.01550	0.03330	0.0940
2.3	200.00	0.2650	0.0611	0.01610	0.02950	0.0928
2.4	251.00	0.2450	0.0395	0.01340	0.01330	0.0657
2.5	316.00	0.2140	0.0403	0.01510	0.01070	0.0698
2.6	398.00	0.1880	0.0399	0.01590	0.00878	0.0709
2.7	501.00	0.1690	0.0367	0.01650	0.00439	0.0691
2.8	631.00	0.1350	0.0317	0.01490	0.00245	0.0609
2.9	794.00	0.1160	0.0292	0.01550	-0.00119	0.0596
3.0	1000.00	0.0861	0.0338	0.02130	-0.00784	0.0755

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.0879	0.160	-0.2260	0.402
0.1	0.9160	1.26	0.0879	0.174	-0.2530	0.428
0.2	0.9110	1.58	0.0879	0.174	-0.2530	0.429
0.3	0.9020	2.00	0.0879	0.175	-0.2560	0.432
0.4	0.8940	2.51	0.0879	0.177	-0.2590	0.435
0.5	0.8790	3.16	0.0879	0.177	-0.2600	0.435
0.6	0.8580	3.98	0.0879	0.177	-0.2600	0.436
0.7	0.8420	5.01	0.0879	0.176	-0.2580	0.433
0.8	0.8280	6.31	0.0879	0.179	-0.2620	0.438
0.9	0.7940	7.94	0.0879	0.185	-0.2740	0.450
1.0	0.7490	10.00	0.0879	0.187	-0.2780	0.454
1.1	0.7100	12.60	0.0879	0.187	-0.2790	0.455
1.2	0.6870	15.80	0.0879	0.191	-0.2860	0.462
1.3	0.6680	20.00	0.0879	0.195	-0.2940	0.470
1.4	0.6080	25.10	0.0879	0.203	-0.3100	0.486
1.5	0.5860	31.60	0.0879	0.206	-0.3160	0.492
1.6	0.5500	39.80	0.0879	0.206	-0.3170	0.492
1.7	0.5220	50.10	0.0879	0.208	-0.3210	0.497
1.8	0.4730	63.10	0.0879	0.223	-0.3480	0.524
1.9	0.4310	79.40	0.0879	0.225	-0.3520	0.528
2.0	0.4060	100.00	0.0879	0.232	-0.3660	0.542
2.1	0.3560	126.00	0.0879	0.263	-0.4280	0.604
2.2	0.3050	158.00	0.0879	0.286	-0.4730	0.649
2.3	0.2650	200.00	0.0879	0.296	-0.4930	0.669
2.4	0.2450	251.00	0.3270	0.242	-0.1470	0.801
2.5	0.2140	316.00	0.3270	0.270	-0.2010	0.856
2.6	0.1880	398.00	0.3270	0.282	-0.2260	0.880
2.7	0.1690	501.00	0.3740	0.291	-0.1970	0.945
2.8	0.1350	631.00	0.4600	0.263	-0.0549	0.975
2.9	0.1160	794.00	0.4630	0.272	-0.0707	0.997
3.0	0.0861	1000.00	0.4630	0.368	-0.2580	1.180

IgG3 V1V2 C.1086-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.0528	0.00678	0.03950	0.0661
0.1	0.8980	1.26	0.0528	0.00811	0.03690	0.0687
0.2	0.8850	1.58	0.0528	0.00807	0.03700	0.0686
0.3	0.8850	2.00	0.0528	0.00807	0.03700	0.0686
0.4	0.8720	2.51	0.0528	0.00820	0.03680	0.0689
0.5	0.8640	3.16	0.0528	0.00823	0.03670	0.0689
0.6	0.8560	3.98	0.0528	0.00827	0.03660	0.0690
0.7	0.8380	5.01	0.0528	0.00842	0.03630	0.0693
0.8	0.8020	6.31	0.0528	0.00839	0.03640	0.0693
0.9	0.7540	7.94	0.0528	0.00872	0.03570	0.0699
1.0	0.7200	10.00	0.0528	0.00914	0.03490	0.0707
1.1	0.6760	12.60	0.0528	0.00952	0.03420	0.0715
1.2	0.6470	15.80	0.0528	0.00963	0.03390	0.0717
1.3	0.6030	20.00	0.0527	0.00976	0.03360	0.0719
1.4	0.5570	25.10	0.0526	0.00995	0.03310	0.0721
1.5	0.5130	31.60	0.0526	0.01000	0.03300	0.0722
1.6	0.4770	39.80	0.0526	0.01060	0.03190	0.0733
1.7	0.4350	50.10	0.0526	0.01110	0.03090	0.0742
1.8	0.3780	63.10	0.0526	0.01290	0.02740	0.0778
1.9	0.3400	79.40	0.0526	0.01340	0.02640	0.0788
2.0	0.3240	100.00	0.0526	0.01370	0.02570	0.0794
2.1	0.3050	126.00	0.0526	0.01380	0.02560	0.0796
2.2	0.2600	158.00	0.0526	0.01560	0.02190	0.0832
2.3	0.2110	200.00	0.0467	0.01580	0.01560	0.0777
2.4	0.1690	251.00	0.0398	0.01430	0.01180	0.0677
2.5	0.1350	316.00	0.0398	0.01560	0.00927	0.0703
2.6	0.0995	398.00	0.0398	0.01940	0.00175	0.0778
2.7	0.0915	501.00	0.0398	0.02130	-0.00196	0.0815

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.0515	0.00678	0.03570	0.0650
0.1	1.26	0.8980	0.0531	0.00811	0.03720	0.0690
0.2	1.58	0.8850	0.0518	0.00807	0.03600	0.0676
0.3	2.00	0.8850	0.0518	0.00807	0.03600	0.0676
0.4	2.51	0.8720	0.0526	0.00820	0.03650	0.0687
0.5	3.16	0.8640	0.0529	0.00823	0.03670	0.0690
0.6	3.98	0.8560	0.0532	0.00827	0.03700	0.0694
0.7	5.01	0.8380	0.0535	0.00842	0.03700	0.0701
0.8	6.31	0.8020	0.0511	0.00839	0.03460	0.0675
0.9	7.94	0.7540	0.0523	0.00872	0.03520	0.0693
1.0	10.00	0.7200	0.0540	0.00914	0.03610	0.0720
1.1	12.60	0.6760	0.0552	0.00952	0.03660	0.0739
1.2	15.80	0.6470	0.0543	0.00963	0.03540	0.0732
1.3	20.00	0.6030	0.0527	0.00976	0.03360	0.0719
1.4	25.10	0.5570	0.0498	0.00995	0.03030	0.0693
1.5	31.60	0.5130	0.0486	0.01000	0.02900	0.0683
1.6	39.80	0.4770	0.0500	0.01060	0.02930	0.0708
1.7	50.10	0.4350	0.0503	0.01110	0.02870	0.0720
1.8	63.10	0.3780	0.0583	0.01290	0.03310	0.0835
1.9	79.40	0.3400	0.0558	0.01340	0.02960	0.0820
2.0	100.00	0.3240	0.0562	0.01370	0.02940	0.0830
2.1	126.00	0.3050	0.0518	0.01380	0.02480	0.0789
2.2	158.00	0.2600	0.0546	0.01560	0.02390	0.0852
2.3	200.00	0.2110	0.0467	0.01580	0.01560	0.0777
2.4	251.00	0.1690	0.0363	0.01430	0.00834	0.0643
2.5	316.00	0.1350	0.0353	0.01560	0.00479	0.0658
2.6	398.00	0.0995	0.0418	0.01940	0.00380	0.0798
2.7	501.00	0.0915	0.0457	0.02130	0.00396	0.0874

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.100	0.159	-0.212	0.412
0.1	0.8980	1.26	0.100	0.176	-0.245	0.445
0.2	0.8850	1.58	0.100	0.176	-0.244	0.444
0.3	0.8850	2.00	0.100	0.176	-0.244	0.444
0.4	0.8720	2.51	0.100	0.177	-0.248	0.448
0.5	0.8640	3.16	0.100	0.178	-0.249	0.448
0.6	0.8560	3.98	0.100	0.178	-0.250	0.450
0.7	0.8380	5.01	0.100	0.180	-0.254	0.454
0.8	0.8020	6.31	0.100	0.180	-0.253	0.453
0.9	0.7540	7.94	0.100	0.184	-0.262	0.461
1.0	0.7200	10.00	0.100	0.190	-0.273	0.473
1.1	0.6760	12.60	0.100	0.196	-0.283	0.483
1.2	0.6470	15.80	0.100	0.197	-0.286	0.486
1.3	0.6030	20.00	0.101	0.199	-0.288	0.491
1.4	0.5570	25.10	0.104	0.201	-0.291	0.499
1.5	0.5130	31.60	0.104	0.202	-0.293	0.501
1.6	0.4770	39.80	0.104	0.210	-0.309	0.516
1.7	0.4350	50.10	0.104	0.218	-0.322	0.530
1.8	0.3780	63.10	0.104	0.245	-0.376	0.583
1.9	0.3400	79.40	0.104	0.252	-0.391	0.598
2.0	0.3240	100.00	0.104	0.257	-0.401	0.609
2.1	0.3050	126.00	0.104	0.259	-0.404	0.611
2.2	0.2600	158.00	0.104	0.288	-0.460	0.668
2.3	0.2110	200.00	0.204	0.287	-0.358	0.766
2.4	0.1690	251.00	0.322	0.257	-0.181	0.825
2.5	0.1350	316.00	0.322	0.278	-0.222	0.867
2.6	0.0995	398.00	0.322	0.341	-0.346	0.990
2.7	0.0915	501.00	0.322	0.372	-0.407	1.050

IgG3 V1V2 C.1086-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.0515	0.00678	0.038200	0.0648
0.1	0.8460	1.26	0.0483	0.00778	0.033100	0.0636
0.2	0.8440	1.58	0.0483	0.00782	0.033000	0.0636
0.3	0.8440	2.00	0.0483	0.00782	0.033000	0.0636
0.4	0.8380	2.51	0.0483	0.00783	0.033000	0.0637
0.5	0.8350	3.16	0.0483	0.00789	0.032900	0.0638
0.6	0.8280	3.98	0.0483	0.00777	0.033100	0.0635
0.7	0.8200	5.01	0.0483	0.00780	0.033000	0.0636
0.8	0.8030	6.31	0.0483	0.00788	0.032900	0.0638
0.9	0.7830	7.94	0.0483	0.00812	0.032400	0.0642
1.0	0.7750	10.00	0.0483	0.00818	0.032300	0.0643
1.1	0.7610	12.60	0.0483	0.00835	0.031900	0.0647
1.2	0.7430	15.80	0.0483	0.00826	0.032100	0.0645
1.3	0.7250	20.00	0.0483	0.00829	0.032100	0.0646
1.4	0.7020	25.10	0.0483	0.00850	0.031600	0.0650
1.5	0.6710	31.60	0.0483	0.00848	0.031700	0.0649
1.6	0.6690	39.80	0.0483	0.00852	0.031600	0.0650
1.7	0.6400	50.10	0.0483	0.00886	0.030900	0.0657
1.8	0.6190	63.10	0.0483	0.00912	0.030400	0.0662
1.9	0.5880	79.40	0.0483	0.00956	0.029600	0.0671
2.0	0.5710	100.00	0.0483	0.00942	0.029800	0.0668
2.1	0.5480	126.00	0.0483	0.00981	0.029100	0.0675
2.2	0.4890	158.00	0.0483	0.01020	0.028400	0.0682
2.3	0.4610	200.00	0.0483	0.01080	0.027100	0.0695
2.4	0.4200	251.00	0.0483	0.01180	0.025200	0.0714
2.5	0.3670	316.00	0.0483	0.01310	0.022700	0.0739
2.6	0.3540	398.00	0.0483	0.01300	0.022900	0.0738
2.7	0.2920	501.00	0.0483	0.01470	0.019500	0.0771
2.8	0.2620	631.00	0.0483	0.01700	0.015100	0.0816
2.9	0.2270	794.00	0.0483	0.01670	0.015500	0.0811
3.0	0.1980	1000.00	0.0481	0.01810	0.012600	0.0837
3.1	0.1810	1260.00	0.0481	0.01880	0.011300	0.0849
3.2	0.1470	1580.00	0.0481	0.02040	0.008050	0.0882
3.3	0.1420	2000.00	0.0481	0.02120	0.006610	0.0897
3.4	0.0954	2510.00	0.0481	0.05340	-0.056600	0.1530
3.5	0.0944	3160.00	0.0341	0.01730	0.000118	0.0680
3.6	0.0741	3980.00	0.0341	0.02090	-0.006910	0.0750

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.0515	0.00678	0.03570	0.0650
0.1	1.26	0.8460	0.0469	0.00778	0.03170	0.0622
0.2	1.58	0.8440	0.0471	0.00782	0.03180	0.0625
0.3	2.00	0.8440	0.0471	0.00782	0.03180	0.0625
0.4	2.51	0.8380	0.0472	0.00783	0.03190	0.0626
0.5	3.16	0.8350	0.0476	0.00789	0.03210	0.0630
0.6	3.98	0.8280	0.0457	0.00777	0.03050	0.0610
0.7	5.01	0.8200	0.0459	0.00780	0.03070	0.0612
0.8	6.31	0.8030	0.0459	0.00788	0.03050	0.0614
0.9	7.94	0.7830	0.0473	0.00812	0.03140	0.0632
1.0	10.00	0.7750	0.0476	0.00818	0.03160	0.0636
1.1	12.60	0.7610	0.0485	0.00835	0.03220	0.0649
1.2	15.80	0.7430	0.0467	0.00826	0.03050	0.0629
1.3	20.00	0.7250	0.0463	0.00829	0.03010	0.0626
1.4	25.10	0.7020	0.0475	0.00850	0.03080	0.0641
1.5	31.60	0.6710	0.0453	0.00848	0.02870	0.0619
1.6	39.80	0.6690	0.0455	0.00852	0.02880	0.0622
1.7	50.10	0.6400	0.0466	0.00886	0.02920	0.0639
1.8	63.10	0.6190	0.0476	0.00912	0.02980	0.0655
1.9	79.40	0.5880	0.0500	0.00956	0.03120	0.0687
2.0	100.00	0.5710	0.0470	0.00942	0.02850	0.0654
2.1	126.00	0.5480	0.0489	0.00981	0.02970	0.0681
2.2	158.00	0.4890	0.0470	0.01020	0.02710	0.0669
2.3	200.00	0.4610	0.0497	0.01080	0.02850	0.0708
2.4	251.00	0.4200	0.0529	0.01180	0.02970	0.0760
2.5	316.00	0.3670	0.0567	0.01310	0.03110	0.0823
2.6	398.00	0.3540	0.0535	0.01300	0.02800	0.0789
2.7	501.00	0.2920	0.0525	0.01470	0.02380	0.0813
2.8	631.00	0.2620	0.0598	0.01700	0.02660	0.0931
2.9	794.00	0.2270	0.0550	0.01670	0.02220	0.0877
3.0	1000.00	0.1980	0.0481	0.01810	0.01250	0.0837
3.1	1260.00	0.1810	0.0453	0.01880	0.00852	0.0821
3.2	1580.00	0.1470	0.0428	0.02040	0.00269	0.0828
3.3	2000.00	0.1420	0.0443	0.02120	0.00274	0.0858
3.4	2510.00	0.0954	0.0830	0.05340	-0.02170	0.1880
3.5	3160.00	0.0944	0.0318	0.01730	-0.00211	0.0658
3.6	3980.00	0.0741	0.0363	0.02090	-0.00467	0.0773

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.122	0.157	-0.186	0.430
0.1	0.8460	1.26	0.177	0.166	-0.149	0.502
0.2	0.8440	1.58	0.177	0.167	-0.150	0.503
0.3	0.8440	2.00	0.177	0.167	-0.150	0.503
0.4	0.8380	2.51	0.177	0.167	-0.150	0.504
0.5	0.8350	3.16	0.177	0.167	-0.151	0.505
0.6	0.8280	3.98	0.177	0.166	-0.148	0.502
0.7	0.8200	5.01	0.177	0.166	-0.149	0.503
0.8	0.8030	6.31	0.177	0.167	-0.151	0.505
0.9	0.7830	7.94	0.177	0.171	-0.158	0.511
1.0	0.7750	10.00	0.177	0.171	-0.159	0.513
1.1	0.7610	12.60	0.177	0.174	-0.164	0.518
1.2	0.7430	15.80	0.177	0.173	-0.161	0.515
1.3	0.7250	20.00	0.177	0.173	-0.162	0.516
1.4	0.7020	25.10	0.177	0.176	-0.168	0.522
1.5	0.6710	31.60	0.177	0.176	-0.168	0.521
1.6	0.6690	39.80	0.177	0.176	-0.169	0.522
1.7	0.6400	50.10	0.177	0.181	-0.178	0.532
1.8	0.6190	63.10	0.177	0.185	-0.185	0.539
1.9	0.5880	79.40	0.177	0.191	-0.198	0.552
2.0	0.5710	100.00	0.177	0.189	-0.194	0.548
2.1	0.5480	126.00	0.177	0.195	-0.205	0.558
2.2	0.4890	158.00	0.177	0.200	-0.215	0.569
2.3	0.4610	200.00	0.177	0.209	-0.234	0.587
2.4	0.4200	251.00	0.177	0.225	-0.263	0.617
2.5	0.3670	316.00	0.177	0.244	-0.302	0.656
2.6	0.3540	398.00	0.177	0.243	-0.299	0.653
2.7	0.2920	501.00	0.177	0.269	-0.351	0.705
2.8	0.2620	631.00	0.177	0.306	-0.423	0.776
2.9	0.2270	794.00	0.177	0.302	-0.415	0.768
3.0	0.1980	1000.00	0.180	0.325	-0.457	0.816
3.1	0.1810	1260.00	0.180	0.335	-0.477	0.837
3.2	0.1470	1580.00	0.180	0.362	-0.531	0.890
3.3	0.1420	2000.00	0.180	0.375	-0.554	0.914
3.4	0.0954	2510.00	0.180	0.916	-1.620	1.970
3.5	0.0944	3160.00	0.419	0.304	-0.175	1.010
3.6	0.0741	3980.00	0.419	0.363	-0.292	1.130

HVTN 702

• Adjustment covariates: AGELE25, RSCORCAT
• Event time variable: HIV6.5_24FU
• Event type variable: HIV6.5_24
• Weight variable: SAMPWT
• Reference timepoint: 552 days
• All learners: GLM

IgG V1V2 B.CaseA-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.136	0.0122	0.11200	0.160
0.1	0.6080	1.26	0.136	0.0309	0.07560	0.197
0.2	0.6080	1.58	0.136	0.0309	0.07560	0.197
0.3	0.6080	2.00	0.136	0.0309	0.07560	0.197
0.4	0.5870	2.51	0.136	0.0331	0.07150	0.201
0.5	0.5870	3.16	0.136	0.0331	0.07150	0.201
0.6	0.5870	3.98	0.136	0.0331	0.07150	0.201
0.7	0.5870	5.01	0.136	0.0331	0.07150	0.201
0.8	0.5870	6.31	0.136	0.0331	0.07150	0.201
0.9	0.5460	7.94	0.136	0.0312	0.07520	0.197
1.0	0.5460	10.00	0.136	0.0312	0.07520	0.197
1.1	0.5460	12.60	0.136	0.0312	0.07520	0.197
1.2	0.5460	15.80	0.136	0.0312	0.07520	0.197
1.3	0.5100	20.00	0.136	0.0313	0.07500	0.198
1.4	0.4850	25.10	0.136	0.0305	0.07650	0.196
1.5	0.4840	31.60	0.136	0.0302	0.07710	0.195
1.6	0.4820	39.80	0.136	0.0299	0.07770	0.195
1.7	0.4800	50.10	0.136	0.0295	0.07840	0.194
1.8	0.4560	63.10	0.136	0.0291	0.07920	0.193
1.9	0.4380	79.40	0.136	0.0300	0.07740	0.195
2.0	0.4120	100.00	0.136	0.0317	0.07420	0.198
2.1	0.3840	126.00	0.136	0.0348	0.06810	0.204
2.2	0.3580	158.00	0.136	0.0399	0.05810	0.215
2.3	0.3400	200.00	0.136	0.0373	0.06320	0.209
2.4	0.3080	251.00	0.136	0.0357	0.06630	0.206
2.5	0.3080	316.00	0.136	0.0357	0.06630	0.206
2.6	0.2700	398.00	0.136	0.0350	0.06760	0.205
2.7	0.2040	501.00	0.136	0.0423	0.05330	0.219
2.8	0.1480	631.00	0.136	0.0689	0.00121	0.271
2.9	0.1310	794.00	0.136	0.0800	-0.02040	0.293
3.0	0.1300	1000.00	0.136	0.0786	-0.01780	0.290
3.1	0.0964	1260.00	0.136	0.1030	-0.06500	0.338
3.2	0.0704	1580.00	0.136	0.1540	-0.16500	0.437
3.3	0.0635	2000.00	0.136	0.1490	-0.15500	0.428
3.4	0.0618	2510.00	0.136	0.1560	-0.16900	0.442
3.5	0.0512	3160.00	0.136	0.1600	-0.17600	0.449

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.0952	0.0122	0.0636	0.129
0.1	1.26	0.6080	0.1300	0.0309	0.0692	0.191
0.2	1.58	0.6080	0.1300	0.0309	0.0692	0.191
0.3	2.00	0.6080	0.1300	0.0309	0.0692	0.191
0.4	2.51	0.5870	0.1360	0.0331	0.0712	0.201
0.5	3.16	0.5870	0.1360	0.0331	0.0712	0.201
0.6	3.98	0.5870	0.1360	0.0331	0.0712	0.201
0.7	5.01	0.5870	0.1360	0.0331	0.0712	0.201
0.8	6.31	0.5870	0.1360	0.0331	0.0712	0.201
0.9	7.94	0.5460	0.1330	0.0312	0.0722	0.194
1.0	10.00	0.5460	0.1330	0.0312	0.0722	0.194
1.1	12.60	0.5460	0.1330	0.0312	0.0722	0.194
1.2	15.80	0.5460	0.1330	0.0312	0.0722	0.194
1.3	20.00	0.5100	0.1360	0.0313	0.0751	0.198
1.4	25.10	0.4850	0.1340	0.0305	0.0747	0.194
1.5	31.60	0.4840	0.1320	0.0302	0.0726	0.191
1.6	39.80	0.4820	0.1290	0.0299	0.0707	0.188
1.7	50.10	0.4800	0.1270	0.0295	0.0687	0.184
1.8	63.10	0.4560	0.1240	0.0291	0.0670	0.181
1.9	79.40	0.4380	0.1240	0.0300	0.0650	0.183
2.0	100.00	0.4120	0.1240	0.0317	0.0618	0.186
2.1	126.00	0.3840	0.1270	0.0348	0.0589	0.195
2.2	158.00	0.3580	0.1360	0.0399	0.0580	0.214
2.3	200.00	0.3400	0.1190	0.0373	0.0456	0.192
2.4	251.00	0.3080	0.1090	0.0357	0.0391	0.179
2.5	316.00	0.3080	0.1090	0.0357	0.0391	0.179
2.6	398.00	0.2700	0.1020	0.0350	0.0329	0.170
2.7	501.00	0.2040	0.1130	0.0423	0.0305	0.196
2.8	631.00	0.1480	0.1900	0.0689	0.0546	0.325
2.9	794.00	0.1310	0.2140	0.0800	0.0572	0.371
3.0	1000.00	0.1300	0.2020	0.0786	0.0475	0.356
3.1	1260.00	0.0964	0.4160	0.1030	0.2150	0.617
3.2	1580.00	0.0704	0.6290	0.1540	0.3280	0.930
3.3	2000.00	0.0635	0.5310	0.1490	0.2400	0.823
3.4	2510.00	0.0618	0.5070	0.1560	0.2010	0.813
3.5	3160.00	0.0512	0.4990	0.1600	0.1860	0.811

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	-0.656	0.276	-1.20	-0.114
0.1	0.6080	1.26	-0.656	0.442	-1.52	0.212
0.2	0.6080	1.58	-0.656	0.442	-1.52	0.212
0.3	0.6080	2.00	-0.656	0.442	-1.52	0.212
0.4	0.5870	2.51	-0.656	0.464	-1.57	0.255
0.5	0.5870	3.16	-0.656	0.464	-1.57	0.255
0.6	0.5870	3.98	-0.656	0.464	-1.57	0.255
0.7	0.5870	5.01	-0.656	0.464	-1.57	0.255
0.8	0.5870	6.31	-0.656	0.464	-1.57	0.255
0.9	0.5460	7.94	-0.656	0.445	-1.53	0.217
1.0	0.5460	10.00	-0.656	0.445	-1.53	0.217
1.1	0.5460	12.60	-0.656	0.445	-1.53	0.217
1.2	0.5460	15.80	-0.656	0.445	-1.53	0.217
1.3	0.5100	20.00	-0.656	0.446	-1.53	0.218
1.4	0.4850	25.10	-0.656	0.438	-1.51	0.203
1.5	0.4840	31.60	-0.656	0.435	-1.51	0.197
1.6	0.4820	39.80	-0.656	0.432	-1.50	0.190
1.7	0.4800	50.10	-0.656	0.428	-1.49	0.183
1.8	0.4560	63.10	-0.656	0.424	-1.49	0.175
1.9	0.4380	79.40	-0.656	0.433	-1.50	0.193
2.0	0.4120	100.00	-0.656	0.450	-1.54	0.227
2.1	0.3840	126.00	-0.656	0.483	-1.60	0.290
2.2	0.3580	158.00	-0.656	0.538	-1.71	0.399
2.3	0.3400	200.00	-0.656	0.509	-1.65	0.343
2.4	0.3080	251.00	-0.656	0.493	-1.62	0.310
2.5	0.3080	316.00	-0.656	0.493	-1.62	0.310
2.6	0.2700	398.00	-0.656	0.485	-1.61	0.296
2.7	0.2040	501.00	-0.656	0.565	-1.76	0.451
2.8	0.1480	631.00	-0.656	0.869	-2.36	1.050
2.9	0.1310	794.00	-0.656	0.999	-2.61	1.300
3.0	0.1300	1000.00	-0.656	0.983	-2.58	1.270
3.1	0.0964	1260.00	-0.656	1.270	-3.14	1.830
3.2	0.0704	1580.00	-0.656	1.880	-4.34	3.030
3.3	0.0635	2000.00	-0.656	1.820	-4.23	2.920
3.4	0.0618	2510.00	-0.656	1.910	-4.40	3.090
3.5	0.0512	3160.00	-0.656	1.950	-4.48	3.170

IgG V1V2 AE.A244-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.0997	0.0122	0.07580	0.124
0.1	0.9580	1.26	0.0997	0.0165	0.06730	0.132
0.2	0.9580	1.58	0.0997	0.0165	0.06730	0.132
0.3	0.9580	2.00	0.0997	0.0165	0.06730	0.132
0.4	0.9580	2.51	0.0997	0.0165	0.06730	0.132
0.5	0.9580	3.16	0.0997	0.0165	0.06730	0.132
0.6	0.9580	3.98	0.0997	0.0165	0.06730	0.132
0.7	0.9580	5.01	0.0997	0.0165	0.06730	0.132
0.8	0.9580	6.31	0.0997	0.0165	0.06730	0.132
0.9	0.9580	7.94	0.0997	0.0165	0.06730	0.132
1.0	0.9580	10.00	0.0997	0.0165	0.06730	0.132
1.1	0.9560	12.60	0.0997	0.0166	0.06710	0.132
1.2	0.9560	15.80	0.0997	0.0166	0.06710	0.132
1.3	0.9540	20.00	0.0997	0.0164	0.06760	0.132
1.4	0.9400	25.10	0.0997	0.0168	0.06670	0.133
1.5	0.9400	31.60	0.0997	0.0168	0.06670	0.133
1.6	0.9400	39.80	0.0997	0.0168	0.06670	0.133
1.7	0.9380	50.10	0.0997	0.0166	0.06710	0.132
1.8	0.9380	63.10	0.0997	0.0166	0.06710	0.132
1.9	0.9150	79.40	0.0997	0.0173	0.06580	0.134
2.0	0.9150	100.00	0.0997	0.0173	0.06580	0.134
2.1	0.9140	126.00	0.0997	0.0171	0.06610	0.133
2.2	0.8980	158.00	0.0997	0.0167	0.06700	0.132
2.3	0.8860	200.00	0.0997	0.0170	0.06630	0.133
2.4	0.8300	251.00	0.0997	0.0182	0.06400	0.135
2.5	0.7770	316.00	0.0997	0.0186	0.06310	0.136
2.6	0.7440	398.00	0.0997	0.0200	0.06050	0.139
2.7	0.7080	501.00	0.0997	0.0207	0.05900	0.140
2.8	0.6200	631.00	0.0997	0.0237	0.05330	0.146
2.9	0.5410	794.00	0.0997	0.0270	0.04680	0.153
3.0	0.4010	1000.00	0.0997	0.0342	0.03260	0.167
3.1	0.3400	1260.00	0.0997	0.0392	0.02290	0.176
3.2	0.2510	1580.00	0.0997	0.0539	-0.00603	0.205
3.3	0.2090	2000.00	0.0997	0.0557	-0.00954	0.209
3.4	0.1890	2510.00	0.0997	0.0523	-0.00280	0.202
3.5	0.1710	3160.00	0.0997	0.0521	-0.00250	0.202
3.6	0.1680	3980.00	0.0997	0.0487	0.00428	0.195
3.7	0.1290	5010.00	0.0997	0.0414	0.01850	0.181
3.8	0.1270	6310.00	0.0997	0.0375	0.02630	0.173
3.9	0.0856	7940.00	0.0997	0.0491	0.00346	0.196
4.0	0.0385	10000.00	0.0997	0.2240	-0.34000	0.539
4.1	0.0279	12600.00	0.0997	0.2350	-0.36200	0.561

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.0952	0.0122	0.06360	0.129
0.1	1.26	0.9580	0.0928	0.0165	0.06040	0.125
0.2	1.58	0.9580	0.0928	0.0165	0.06040	0.125
0.3	2.00	0.9580	0.0928	0.0165	0.06040	0.125
0.4	2.51	0.9580	0.0928	0.0165	0.06040	0.125
0.5	3.16	0.9580	0.0928	0.0165	0.06040	0.125
0.6	3.98	0.9580	0.0928	0.0165	0.06040	0.125
0.7	5.01	0.9580	0.0928	0.0165	0.06040	0.125
0.8	6.31	0.9580	0.0928	0.0165	0.06040	0.125
0.9	7.94	0.9580	0.0928	0.0165	0.06040	0.125
1.0	10.00	0.9580	0.0928	0.0165	0.06040	0.125
1.1	12.60	0.9560	0.0932	0.0166	0.06060	0.126
1.2	15.80	0.9560	0.0932	0.0166	0.06060	0.126
1.3	20.00	0.9540	0.0915	0.0164	0.05940	0.124
1.4	25.10	0.9400	0.0936	0.0168	0.06060	0.127
1.5	31.60	0.9400	0.0936	0.0168	0.06060	0.127
1.6	39.80	0.9400	0.0936	0.0168	0.06060	0.127
1.7	50.10	0.9380	0.0918	0.0166	0.05930	0.124
1.8	63.10	0.9380	0.0918	0.0166	0.05930	0.124
1.9	79.40	0.9150	0.0947	0.0173	0.06080	0.129
2.0	100.00	0.9150	0.0947	0.0173	0.06080	0.129
2.1	126.00	0.9140	0.0932	0.0171	0.05960	0.127
2.2	158.00	0.8980	0.0884	0.0167	0.05570	0.121
2.3	200.00	0.8860	0.0889	0.0170	0.05550	0.122
2.4	251.00	0.8300	0.0929	0.0182	0.05720	0.129
2.5	316.00	0.7770	0.0905	0.0186	0.05390	0.127
2.6	398.00	0.7440	0.0932	0.0200	0.05410	0.132
2.7	501.00	0.7080	0.0927	0.0207	0.05200	0.133
2.8	631.00	0.6200	0.0980	0.0237	0.05160	0.144
2.9	794.00	0.5410	0.1070	0.0270	0.05460	0.160
3.0	1000.00	0.4010	0.1320	0.0342	0.06440	0.199
3.1	1260.00	0.3400	0.1400	0.0392	0.06330	0.217
3.2	1580.00	0.2510	0.1770	0.0539	0.07080	0.282
3.3	2000.00	0.2090	0.1620	0.0557	0.05230	0.271
3.4	2510.00	0.1890	0.1500	0.0523	0.04740	0.252
3.5	3160.00	0.1710	0.1450	0.0521	0.04260	0.247
3.6	3980.00	0.1680	0.1270	0.0487	0.03150	0.222
3.7	5010.00	0.1290	0.0922	0.0414	0.01100	0.173
3.8	6310.00	0.1270	0.0781	0.0375	0.00469	0.152
3.9	7940.00	0.0856	0.0895	0.0491	-0.00675	0.186
4.0	10000.00	0.0385	0.4350	0.2240	-0.00457	0.874
4.1	12600.00	0.0279	0.4590	0.2350	-0.00225	0.920

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	-0.211	0.226	-0.654	0.232
0.1	0.9580	1.26	-0.211	0.264	-0.727	0.306
0.2	0.9580	1.58	-0.211	0.264	-0.727	0.306
0.3	0.9580	2.00	-0.211	0.264	-0.727	0.306
0.4	0.9580	2.51	-0.211	0.264	-0.727	0.306
0.5	0.9580	3.16	-0.211	0.264	-0.727	0.306
0.6	0.9580	3.98	-0.211	0.264	-0.727	0.306
0.7	0.9580	5.01	-0.211	0.264	-0.727	0.306
0.8	0.9580	6.31	-0.211	0.264	-0.727	0.306
0.9	0.9580	7.94	-0.211	0.264	-0.727	0.306
1.0	0.9580	10.00	-0.211	0.264	-0.727	0.306
1.1	0.9560	12.60	-0.211	0.264	-0.729	0.307
1.2	0.9560	15.80	-0.211	0.264	-0.729	0.307
1.3	0.9540	20.00	-0.211	0.262	-0.725	0.303
1.4	0.9400	25.10	-0.211	0.266	-0.733	0.311
1.5	0.9400	31.60	-0.211	0.266	-0.733	0.311
1.6	0.9400	39.80	-0.211	0.266	-0.733	0.311
1.7	0.9380	50.10	-0.211	0.264	-0.729	0.307
1.8	0.9380	63.10	-0.211	0.264	-0.729	0.307
1.9	0.9150	79.40	-0.211	0.271	-0.742	0.320
2.0	0.9150	100.00	-0.211	0.271	-0.742	0.320
2.1	0.9140	126.00	-0.211	0.269	-0.739	0.317
2.2	0.8980	158.00	-0.211	0.265	-0.730	0.308
2.3	0.8860	200.00	-0.211	0.268	-0.737	0.315
2.4	0.8300	251.00	-0.211	0.279	-0.758	0.336
2.5	0.7770	316.00	-0.211	0.284	-0.767	0.345
2.6	0.7440	398.00	-0.211	0.297	-0.792	0.371
2.7	0.7080	501.00	-0.211	0.304	-0.808	0.386
2.8	0.6200	631.00	-0.211	0.334	-0.866	0.445
2.9	0.5410	794.00	-0.211	0.370	-0.935	0.514
3.0	0.4010	1000.00	-0.211	0.450	-1.090	0.670
3.1	0.3400	1260.00	-0.211	0.506	-1.200	0.780
3.2	0.2510	1580.00	-0.211	0.677	-1.540	1.120
3.3	0.2090	2000.00	-0.211	0.698	-1.580	1.160
3.4	0.1890	2510.00	-0.211	0.658	-1.500	1.080
3.5	0.1710	3160.00	-0.211	0.656	-1.500	1.070
3.6	0.1680	3980.00	-0.211	0.615	-1.420	0.995
3.7	0.1290	5010.00	-0.211	0.531	-1.250	0.830
3.8	0.1270	6310.00	-0.211	0.486	-1.160	0.742
3.9	0.0856	7940.00	-0.211	0.620	-1.430	1.000
4.0	0.0385	10000.00	-0.211	2.730	-5.560	5.140
4.1	0.0279	12600.00	-0.211	2.860	-5.830	5.400

IgG V1V2 C.1086-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.0985	0.0122	0.07460	0.122
0.1	0.9730	1.26	0.0985	0.0170	0.06520	0.132
0.2	0.9730	1.58	0.0985	0.0170	0.06520	0.132
0.3	0.9730	2.00	0.0985	0.0170	0.06520	0.132
0.4	0.9730	2.51	0.0985	0.0170	0.06520	0.132
0.5	0.9730	3.16	0.0985	0.0170	0.06520	0.132
0.6	0.9730	3.98	0.0985	0.0170	0.06520	0.132
0.7	0.9710	5.01	0.0985	0.0168	0.06560	0.131
0.8	0.9710	6.31	0.0985	0.0168	0.06560	0.131
0.9	0.9710	7.94	0.0985	0.0168	0.06560	0.131
1.0	0.9700	10.00	0.0985	0.0166	0.06600	0.131
1.1	0.9550	12.60	0.0985	0.0170	0.06510	0.132
1.2	0.9540	15.80	0.0985	0.0168	0.06550	0.132
1.3	0.9540	20.00	0.0985	0.0168	0.06550	0.132
1.4	0.9310	25.10	0.0985	0.0175	0.06410	0.133
1.5	0.9270	31.60	0.0985	0.0175	0.06420	0.133
1.6	0.9260	39.80	0.0985	0.0173	0.06460	0.132
1.7	0.9120	50.10	0.0985	0.0170	0.06510	0.132
1.8	0.9100	63.10	0.0985	0.0168	0.06560	0.131
1.9	0.8960	79.40	0.0985	0.0170	0.06520	0.132
2.0	0.8600	100.00	0.0985	0.0181	0.06300	0.134
2.1	0.8260	126.00	0.0985	0.0185	0.06210	0.135
2.2	0.8060	158.00	0.0985	0.0189	0.06140	0.136
2.3	0.7410	200.00	0.0985	0.0202	0.05890	0.138
2.4	0.6930	251.00	0.0985	0.0247	0.05000	0.147
2.5	0.5700	316.00	0.0985	0.0237	0.05210	0.145
2.6	0.5230	398.00	0.0985	0.0251	0.04920	0.148
2.7	0.4260	501.00	0.0985	0.0286	0.04250	0.155
2.8	0.3590	631.00	0.0985	0.0348	0.03040	0.167
2.9	0.2870	794.00	0.0985	0.0410	0.01800	0.179
3.0	0.2660	1000.00	0.0985	0.0378	0.02430	0.173
3.1	0.2050	1260.00	0.0985	0.0425	0.01520	0.182
3.2	0.1590	1580.00	0.0985	0.0472	0.00602	0.191
3.3	0.1390	2000.00	0.0985	0.0394	0.02130	0.176
3.4	0.1110	2510.00	0.0985	0.0405	0.01920	0.178
3.5	0.0506	3160.00	0.0985	0.0928	-0.08340	0.280
3.6	0.0263	3980.00	0.0985	0.2510	-0.39400	0.591

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.0952	0.0122	0.06360	0.129
0.1	1.26	0.9730	0.0973	0.0170	0.06400	0.131
0.2	1.58	0.9730	0.0973	0.0170	0.06400	0.131
0.3	2.00	0.9730	0.0973	0.0170	0.06400	0.131
0.4	2.51	0.9730	0.0973	0.0170	0.06400	0.131
0.5	3.16	0.9730	0.0973	0.0170	0.06400	0.131
0.6	3.98	0.9730	0.0973	0.0170	0.06400	0.131
0.7	5.01	0.9710	0.0956	0.0168	0.06280	0.129
0.8	6.31	0.9710	0.0956	0.0168	0.06280	0.129
0.9	7.94	0.9710	0.0956	0.0168	0.06280	0.129
1.0	10.00	0.9700	0.0939	0.0166	0.06140	0.126
1.1	12.60	0.9550	0.0962	0.0170	0.06280	0.130
1.2	15.80	0.9540	0.0945	0.0168	0.06150	0.128
1.3	20.00	0.9540	0.0945	0.0168	0.06150	0.128
1.4	25.10	0.9310	0.0977	0.0175	0.06330	0.132
1.5	31.60	0.9270	0.0964	0.0175	0.06220	0.131
1.6	39.80	0.9260	0.0948	0.0173	0.06090	0.129
1.7	50.10	0.9120	0.0918	0.0170	0.05840	0.125
1.8	63.10	0.9100	0.0899	0.0168	0.05700	0.123
1.9	79.40	0.8960	0.0888	0.0170	0.05560	0.122
2.0	100.00	0.8600	0.0936	0.0181	0.05800	0.129
2.1	126.00	0.8260	0.0924	0.0185	0.05600	0.129
2.2	158.00	0.8060	0.0907	0.0189	0.05350	0.128
2.3	200.00	0.7410	0.0921	0.0202	0.05250	0.132
2.4	251.00	0.6930	0.1050	0.0247	0.05690	0.154
2.5	316.00	0.5700	0.1050	0.0237	0.05830	0.151
2.6	398.00	0.5230	0.1070	0.0251	0.05800	0.156
2.7	501.00	0.4260	0.1130	0.0286	0.05700	0.169
2.8	631.00	0.3590	0.1220	0.0348	0.05430	0.190
2.9	794.00	0.2870	0.1350	0.0410	0.05500	0.216
3.0	1000.00	0.2660	0.1180	0.0378	0.04380	0.192
3.1	1260.00	0.2050	0.1100	0.0425	0.02670	0.193
3.2	1580.00	0.1590	0.1120	0.0472	0.01920	0.204
3.3	2000.00	0.1390	0.0868	0.0394	0.00965	0.164
3.4	2510.00	0.1110	0.0815	0.0405	0.00218	0.161
3.5	3160.00	0.0506	0.1160	0.0928	-0.06570	0.298
3.6	3980.00	0.0263	0.4350	0.2510	-0.05770	0.928

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	-0.196	0.224	-0.636	0.243
0.1	0.9730	1.26	-0.196	0.267	-0.719	0.326
0.2	0.9730	1.58	-0.196	0.267	-0.719	0.326
0.3	0.9730	2.00	-0.196	0.267	-0.719	0.326
0.4	0.9730	2.51	-0.196	0.267	-0.719	0.326
0.5	0.9730	3.16	-0.196	0.267	-0.719	0.326
0.6	0.9730	3.98	-0.196	0.267	-0.719	0.326
0.7	0.9710	5.01	-0.196	0.265	-0.715	0.322
0.8	0.9710	6.31	-0.196	0.265	-0.715	0.322
0.9	0.9710	7.94	-0.196	0.265	-0.715	0.322
1.0	0.9700	10.00	-0.196	0.263	-0.711	0.318
1.1	0.9550	12.60	-0.196	0.267	-0.720	0.327
1.2	0.9540	15.80	-0.196	0.265	-0.716	0.323
1.3	0.9540	20.00	-0.196	0.265	-0.716	0.323
1.4	0.9310	25.10	-0.196	0.272	-0.729	0.336
1.5	0.9270	31.60	-0.196	0.271	-0.728	0.335
1.6	0.9260	39.80	-0.196	0.269	-0.724	0.331
1.7	0.9120	50.10	-0.196	0.267	-0.720	0.327
1.8	0.9100	63.10	-0.196	0.265	-0.715	0.322
1.9	0.8960	79.40	-0.196	0.266	-0.718	0.325
2.0	0.8600	100.00	-0.196	0.277	-0.740	0.347
2.1	0.8260	126.00	-0.196	0.281	-0.748	0.355
2.2	0.8060	158.00	-0.196	0.285	-0.756	0.363
2.3	0.7410	200.00	-0.196	0.298	-0.780	0.387
2.4	0.6930	251.00	-0.196	0.344	-0.872	0.479
2.5	0.5700	316.00	-0.196	0.334	-0.850	0.457
2.6	0.5230	398.00	-0.196	0.349	-0.880	0.487
2.7	0.4260	501.00	-0.196	0.386	-0.953	0.560
2.8	0.3590	631.00	-0.196	0.455	-1.090	0.695
2.9	0.2870	794.00	-0.196	0.526	-1.230	0.835
3.0	0.2660	1000.00	-0.196	0.490	-1.160	0.763
3.1	0.2050	1260.00	-0.196	0.543	-1.260	0.868
3.2	0.1590	1580.00	-0.196	0.597	-1.370	0.974
3.3	0.1390	2000.00	-0.196	0.507	-1.190	0.798
3.4	0.1110	2510.00	-0.196	0.520	-1.210	0.822
3.5	0.0506	3160.00	-0.196	1.140	-2.430	2.040
3.6	0.0263	3980.00	-0.196	3.060	-6.190	5.800

IgG V1V2 C.1086-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.0990	0.0122	0.07510	0.123
0.1	0.9840	1.26	0.0990	0.0165	0.06660	0.131
0.2	0.9840	1.58	0.0990	0.0165	0.06660	0.131
0.3	0.9840	2.00	0.0990	0.0165	0.06660	0.131
0.4	0.9840	2.51	0.0990	0.0165	0.06660	0.131
0.5	0.9840	3.16	0.0990	0.0165	0.06660	0.131
0.6	0.9840	3.98	0.0990	0.0165	0.06660	0.131
0.7	0.9840	5.01	0.0990	0.0165	0.06660	0.131
0.8	0.9840	6.31	0.0990	0.0165	0.06660	0.131
0.9	0.9840	7.94	0.0990	0.0165	0.06660	0.131
1.0	0.9840	10.00	0.0990	0.0165	0.06660	0.131
1.1	0.9700	12.60	0.0990	0.0170	0.06570	0.132
1.2	0.9700	15.80	0.0990	0.0170	0.06570	0.132
1.3	0.9700	20.00	0.0990	0.0170	0.06570	0.132
1.4	0.9700	25.10	0.0990	0.0170	0.06570	0.132
1.5	0.9680	31.60	0.0990	0.0168	0.06600	0.132
1.6	0.9580	39.80	0.0990	0.0169	0.06590	0.132
1.7	0.9410	50.10	0.0990	0.0168	0.06600	0.132
1.8	0.9410	63.10	0.0990	0.0168	0.06600	0.132
1.9	0.9400	79.40	0.0990	0.0166	0.06640	0.132
2.0	0.9400	100.00	0.0990	0.0166	0.06640	0.132
2.1	0.9380	126.00	0.0990	0.0167	0.06630	0.132
2.2	0.8780	158.00	0.0990	0.0179	0.06380	0.134
2.3	0.8760	200.00	0.0990	0.0178	0.06410	0.134
2.4	0.8760	251.00	0.0990	0.0178	0.06410	0.134
2.5	0.8710	316.00	0.0990	0.0172	0.06530	0.133
2.6	0.8320	398.00	0.0990	0.0179	0.06400	0.134
2.7	0.7830	501.00	0.0990	0.0198	0.06010	0.138
2.8	0.7360	631.00	0.0990	0.0209	0.05810	0.140
2.9	0.6600	794.00	0.0990	0.0222	0.05550	0.142
3.0	0.6200	1000.00	0.0990	0.0236	0.05270	0.145
3.1	0.5880	1260.00	0.0990	0.0225	0.05490	0.143
3.2	0.5130	1580.00	0.0990	0.0268	0.04650	0.151
3.3	0.4550	2000.00	0.0990	0.0304	0.03930	0.159
3.4	0.3850	2510.00	0.0990	0.0313	0.03760	0.160
3.5	0.3240	3160.00	0.0990	0.0346	0.03110	0.167
3.6	0.2410	3980.00	0.0990	0.0610	-0.02060	0.219
3.7	0.1950	5010.00	0.0990	0.0571	-0.01300	0.211
3.8	0.1770	6310.00	0.0990	0.0521	-0.00310	0.201
3.9	0.1680	7940.00	0.0990	0.0457	0.00948	0.188
4.0	0.1260	10000.00	0.0990	0.0568	-0.01230	0.210
4.1	0.1220	12600.00	0.0990	0.0558	-0.01030	0.208
4.2	0.1060	15800.00	0.0990	0.0519	-0.00284	0.201
4.3	0.0878	20000.00	0.0917	0.0484	-0.00310	0.187

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.0952	0.0122	0.0636	0.129
0.1	1.26	0.9840	0.0935	0.0165	0.0611	0.126
0.2	1.58	0.9840	0.0935	0.0165	0.0611	0.126
0.3	2.00	0.9840	0.0935	0.0165	0.0611	0.126
0.4	2.51	0.9840	0.0935	0.0165	0.0611	0.126
0.5	3.16	0.9840	0.0935	0.0165	0.0611	0.126
0.6	3.98	0.9840	0.0935	0.0165	0.0611	0.126
0.7	5.01	0.9840	0.0935	0.0165	0.0611	0.126
0.8	6.31	0.9840	0.0935	0.0165	0.0611	0.126
0.9	7.94	0.9840	0.0935	0.0165	0.0611	0.126
1.0	10.00	0.9840	0.0935	0.0165	0.0611	0.126
1.1	12.60	0.9700	0.0959	0.0170	0.0626	0.129
1.2	15.80	0.9700	0.0959	0.0170	0.0626	0.129
1.3	20.00	0.9700	0.0959	0.0170	0.0626	0.129
1.4	25.10	0.9700	0.0959	0.0170	0.0626	0.129
1.5	31.60	0.9680	0.0943	0.0168	0.0614	0.127
1.6	39.80	0.9580	0.0947	0.0169	0.0615	0.128
1.7	50.10	0.9410	0.0936	0.0168	0.0606	0.127
1.8	63.10	0.9410	0.0936	0.0168	0.0606	0.127
1.9	79.40	0.9400	0.0918	0.0166	0.0593	0.124
2.0	100.00	0.9400	0.0918	0.0166	0.0593	0.124
2.1	126.00	0.9380	0.0922	0.0167	0.0595	0.125
2.2	158.00	0.8780	0.0976	0.0179	0.0624	0.133
2.3	200.00	0.8760	0.0960	0.0178	0.0612	0.131
2.4	251.00	0.8760	0.0960	0.0178	0.0612	0.131
2.5	316.00	0.8710	0.0906	0.0172	0.0570	0.124
2.6	398.00	0.8320	0.0928	0.0179	0.0578	0.128
2.7	501.00	0.7830	0.0986	0.0198	0.0598	0.137
2.8	631.00	0.7360	0.0978	0.0209	0.0569	0.139
2.9	794.00	0.6600	0.1000	0.0222	0.0567	0.144
3.0	1000.00	0.6200	0.1020	0.0236	0.0555	0.148
3.1	1260.00	0.5880	0.0916	0.0225	0.0475	0.136
3.2	1580.00	0.5130	0.1020	0.0268	0.0491	0.154
3.3	2000.00	0.4550	0.1150	0.0304	0.0555	0.175
3.4	2510.00	0.3850	0.1200	0.0313	0.0582	0.181
3.5	3160.00	0.3240	0.1180	0.0346	0.0499	0.186
3.6	3980.00	0.2410	0.1710	0.0610	0.0512	0.290
3.7	5010.00	0.1950	0.1600	0.0571	0.0482	0.272
3.8	6310.00	0.1770	0.1430	0.0521	0.0413	0.245
3.9	7940.00	0.1680	0.1100	0.0457	0.0204	0.199
4.0	10000.00	0.1260	0.1350	0.0568	0.0241	0.247
4.1	12600.00	0.1220	0.1260	0.0558	0.0167	0.235
4.2	15800.00	0.1060	0.1160	0.0519	0.0137	0.217
4.3	20000.00	0.0878	0.0917	0.0484	-0.0031	0.187

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	-0.202	0.225	-0.643	0.239
0.1	0.9840	1.26	-0.202	0.263	-0.717	0.312
0.2	0.9840	1.58	-0.202	0.263	-0.717	0.312
0.3	0.9840	2.00	-0.202	0.263	-0.717	0.312
0.4	0.9840	2.51	-0.202	0.263	-0.717	0.312
0.5	0.9840	3.16	-0.202	0.263	-0.717	0.312
0.6	0.9840	3.98	-0.202	0.263	-0.717	0.312
0.7	0.9840	5.01	-0.202	0.263	-0.717	0.312
0.8	0.9840	6.31	-0.202	0.263	-0.717	0.312
0.9	0.9840	7.94	-0.202	0.263	-0.717	0.312
1.0	0.9840	10.00	-0.202	0.263	-0.717	0.312
1.1	0.9700	12.60	-0.202	0.267	-0.726	0.321
1.2	0.9700	15.80	-0.202	0.267	-0.726	0.321
1.3	0.9700	20.00	-0.202	0.267	-0.726	0.321
1.4	0.9700	25.10	-0.202	0.267	-0.726	0.321
1.5	0.9680	31.60	-0.202	0.266	-0.723	0.318
1.6	0.9580	39.80	-0.202	0.266	-0.724	0.319
1.7	0.9410	50.10	-0.202	0.265	-0.723	0.318
1.8	0.9410	63.10	-0.202	0.265	-0.723	0.318
1.9	0.9400	79.40	-0.202	0.263	-0.719	0.314
2.0	0.9400	100.00	-0.202	0.263	-0.719	0.314
2.1	0.9380	126.00	-0.202	0.264	-0.720	0.315
2.2	0.8780	158.00	-0.202	0.276	-0.743	0.339
2.3	0.8760	200.00	-0.202	0.274	-0.740	0.336
2.4	0.8760	251.00	-0.202	0.274	-0.740	0.336
2.5	0.8710	316.00	-0.202	0.269	-0.729	0.324
2.6	0.8320	398.00	-0.202	0.275	-0.742	0.337
2.7	0.7830	501.00	-0.202	0.294	-0.779	0.375
2.8	0.7360	631.00	-0.202	0.305	-0.800	0.395
2.9	0.6600	794.00	-0.202	0.318	-0.826	0.421
3.0	0.6200	1000.00	-0.202	0.333	-0.855	0.450
3.1	0.5880	1260.00	-0.202	0.321	-0.832	0.427
3.2	0.5130	1580.00	-0.202	0.367	-0.922	0.517
3.3	0.4550	2000.00	-0.202	0.407	-0.999	0.595
3.4	0.3850	2510.00	-0.202	0.416	-1.020	0.614
3.5	0.3240	3160.00	-0.202	0.454	-1.090	0.687
3.6	0.2410	3980.00	-0.202	0.760	-1.690	1.290
3.7	0.1950	5010.00	-0.202	0.714	-1.600	1.200
3.8	0.1770	6310.00	-0.202	0.655	-1.490	1.080
3.9	0.1680	7940.00	-0.202	0.580	-1.340	0.934
4.0	0.1260	10000.00	-0.202	0.710	-1.590	1.190
4.1	0.1220	12600.00	-0.202	0.698	-1.570	1.170
4.2	0.1060	15800.00	-0.202	0.653	-1.480	1.080
4.3	0.0878	20000.00	-0.114	0.608	-1.310	1.080

IgG3 V1V2 B.CaseA-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.181	0.0122	0.15800	0.205
0.1	0.2810	1.26	0.181	0.0387	0.10600	0.257
0.2	0.2810	1.58	0.181	0.0387	0.10600	0.257
0.3	0.2810	2.00	0.181	0.0387	0.10600	0.257
0.4	0.2550	2.51	0.181	0.0394	0.10400	0.259
0.5	0.2530	3.16	0.181	0.0383	0.10600	0.257
0.6	0.2300	3.98	0.181	0.0503	0.08280	0.280
0.7	0.2080	5.01	0.181	0.0523	0.07890	0.284
0.8	0.1920	6.31	0.181	0.0688	0.04670	0.316
0.9	0.1920	7.94	0.181	0.0688	0.04670	0.316
1.0	0.1330	10.00	0.181	0.0977	-0.01000	0.373
1.1	0.1330	12.60	0.181	0.0977	-0.01000	0.373
1.2	0.1310	15.80	0.181	0.0967	-0.00817	0.371
1.3	0.1200	20.00	0.181	0.1080	-0.02990	0.393
1.4	0.1190	25.10	0.181	0.1050	-0.02400	0.387
1.5	0.1170	31.60	0.181	0.1080	-0.02990	0.393
1.6	0.1070	39.80	0.181	0.1020	-0.01850	0.381
1.7	0.0574	50.10	0.181	0.1240	-0.06070	0.424
1.8	0.0556	63.10	0.181	0.1270	-0.06770	0.431
1.9	0.0539	79.40	0.181	0.1360	-0.08580	0.449
2.0	0.0418	100.00	0.181	0.1420	-0.09670	0.460
2.1	0.0418	126.00	0.181	0.1420	-0.09670	0.460
2.2	0.0383	158.00	0.181	0.1580	-0.12900	0.492
2.3	0.0383	200.00	0.181	0.1580	-0.12900	0.492
2.4	0.0383	251.00	0.181	0.1580	-0.12900	0.492
2.5	0.0383	316.00	0.181	0.1580	-0.12900	0.492
2.6	0.0365	398.00	0.181	0.1130	-0.03990	0.403
2.7	0.0365	501.00	0.181	0.1130	-0.03990	0.403
2.8	0.0365	631.00	0.181	0.1130	-0.03990	0.403

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.0952	0.0122	0.0648	0.130
0.1	1.26	0.2810	0.1150	0.0387	0.0389	0.191
0.2	1.58	0.2810	0.1150	0.0387	0.0389	0.191
0.3	2.00	0.2810	0.1150	0.0387	0.0389	0.191
0.4	2.51	0.2550	0.1110	0.0394	0.0340	0.188
0.5	3.16	0.2530	0.1060	0.0383	0.0308	0.181
0.6	3.98	0.2300	0.1230	0.0503	0.0246	0.222
0.7	5.01	0.2080	0.1350	0.0523	0.0323	0.237
0.8	6.31	0.1920	0.1740	0.0688	0.0388	0.308
0.9	7.94	0.1920	0.1740	0.0688	0.0388	0.308
1.0	10.00	0.1330	0.2710	0.0977	0.0797	0.463
1.1	12.60	0.1330	0.2710	0.0977	0.0797	0.463
1.2	15.80	0.1310	0.2610	0.0967	0.0718	0.451
1.3	20.00	0.1200	0.2870	0.1080	0.0759	0.498
1.4	25.10	0.1190	0.2760	0.1050	0.0709	0.482
1.5	31.60	0.1170	0.2630	0.1080	0.0518	0.474
1.6	39.80	0.1070	0.4530	0.1020	0.2530	0.653
1.7	50.10	0.0574	0.5390	0.1240	0.2970	0.781
1.8	63.10	0.0556	0.5400	0.1270	0.2910	0.789
1.9	79.40	0.0539	0.5300	0.1360	0.2630	0.797
2.0	100.00	0.0418	0.5220	0.1420	0.2440	0.800
2.1	126.00	0.0418	0.5220	0.1420	0.2440	0.800
2.2	158.00	0.0383	0.5010	0.1580	0.1910	0.811
2.3	200.00	0.0383	0.5010	0.1580	0.1910	0.811
2.4	251.00	0.0383	0.5010	0.1580	0.1910	0.811
2.5	316.00	0.0383	0.5010	0.1580	0.1910	0.811
2.6	398.00	0.0365	0.3660	0.1130	0.1450	0.588
2.7	501.00	0.0365	0.3660	0.1130	0.1450	0.588
2.8	631.00	0.0365	0.3660	0.1130	0.1450	0.588

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	-1.2	0.344	-1.88	-0.5290
0.1	0.2810	1.26	-1.2	0.563	-2.31	-0.0998
0.2	0.2810	1.58	-1.2	0.563	-2.31	-0.0998
0.3	0.2810	2.00	-1.2	0.563	-2.31	-0.0998
0.4	0.2550	2.51	-1.2	0.571	-2.32	-0.0855
0.5	0.2530	3.16	-1.2	0.560	-2.30	-0.1070
0.6	0.2300	3.98	-1.2	0.686	-2.55	0.1400
0.7	0.2080	5.01	-1.2	0.707	-2.59	0.1830
0.8	0.1920	6.31	-1.2	0.891	-2.95	0.5430
0.9	0.1920	7.94	-1.2	0.891	-2.95	0.5430
1.0	0.1330	10.00	-1.2	1.230	-3.61	1.2000
1.1	0.1330	12.60	-1.2	1.230	-3.61	1.2000
1.2	0.1310	15.80	-1.2	1.220	-3.59	1.1800
1.3	0.1200	20.00	-1.2	1.350	-3.84	1.4300
1.4	0.1190	25.10	-1.2	1.310	-3.77	1.3600
1.5	0.1170	31.60	-1.2	1.350	-3.84	1.4300
1.6	0.1070	39.80	-1.2	1.280	-3.71	1.3000
1.7	0.0574	50.10	-1.2	1.530	-4.21	1.8000
1.8	0.0556	63.10	-1.2	1.580	-4.29	1.8800
1.9	0.0539	79.40	-1.2	1.690	-4.51	2.1000
2.0	0.0418	100.00	-1.2	1.750	-4.64	2.2300
2.1	0.0418	126.00	-1.2	1.750	-4.64	2.2300
2.2	0.0383	158.00	-1.2	1.950	-5.02	2.6200
2.3	0.0383	200.00	-1.2	1.950	-5.02	2.6200
2.4	0.0383	251.00	-1.2	1.950	-5.02	2.6200
2.5	0.0383	316.00	-1.2	1.950	-5.02	2.6200
2.6	0.0365	398.00	-1.2	1.410	-3.96	1.5500
2.7	0.0365	501.00	-1.2	1.410	-3.96	1.5500
2.8	0.0365	631.00	-1.2	1.410	-3.96	1.5500

IgG3 V1V2 AE.A244-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.154	0.0122	0.13000	0.178
0.1	0.9130	1.26	0.154	0.0184	0.11800	0.190
0.2	0.9130	1.58	0.154	0.0184	0.11800	0.190
0.3	0.9120	2.00	0.154	0.0183	0.11800	0.190
0.4	0.8580	2.51	0.154	0.0194	0.11600	0.192
0.5	0.8580	3.16	0.154	0.0194	0.11600	0.192
0.6	0.8560	3.98	0.154	0.0192	0.11600	0.192
0.7	0.8330	5.01	0.154	0.0199	0.11500	0.193
0.8	0.7950	6.31	0.154	0.0205	0.11400	0.194
0.9	0.7910	7.94	0.154	0.0200	0.11500	0.193
1.0	0.7840	10.00	0.154	0.0190	0.11700	0.191
1.1	0.7840	12.60	0.154	0.0190	0.11700	0.191
1.2	0.7340	15.80	0.154	0.0215	0.11200	0.196
1.3	0.6930	20.00	0.154	0.0252	0.10500	0.203
1.4	0.6550	25.10	0.154	0.0284	0.09830	0.210
1.5	0.5710	31.60	0.154	0.0349	0.08560	0.222
1.6	0.5370	39.80	0.154	0.0316	0.09210	0.216
1.7	0.4730	50.10	0.154	0.0322	0.09080	0.217
1.8	0.4460	63.10	0.154	0.0336	0.08800	0.220
1.9	0.4100	79.40	0.154	0.0396	0.07640	0.232
2.0	0.3940	100.00	0.154	0.0430	0.06970	0.238
2.1	0.3730	126.00	0.154	0.0468	0.06230	0.246
2.2	0.3250	158.00	0.154	0.0544	0.04740	0.261
2.3	0.2920	200.00	0.154	0.0529	0.05040	0.258
2.4	0.2150	251.00	0.154	0.0812	-0.00514	0.313
2.5	0.2050	316.00	0.154	0.0978	-0.03760	0.346
2.6	0.1310	398.00	0.154	0.0955	-0.03320	0.341
2.7	0.1160	501.00	0.154	0.1120	-0.06470	0.373
2.8	0.0907	631.00	0.154	0.1330	-0.10800	0.416
2.9	0.0907	794.00	0.154	0.1330	-0.10800	0.416
3.0	0.0630	1000.00	0.154	0.2440	-0.32500	0.632
3.1	0.0612	1260.00	0.154	0.2440	-0.32500	0.633
3.2	0.0578	1580.00	0.154	0.2500	-0.33500	0.643
3.3	0.0335	2000.00	0.154	0.2210	-0.27900	0.587
3.4	0.0318	2510.00	0.154	0.2270	-0.29200	0.600
3.5	0.0156	3160.00	0.154	0.2810	-0.39700	0.705
3.6	0.0156	3980.00	0.154	0.2810	-0.39700	0.705
3.7	0.0156	5010.00	0.154	0.2810	-0.39700	0.705
3.8	0.0156	6310.00	0.154	0.2810	-0.39700	0.705

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.0952	0.0122	0.0648	0.130
0.1	1.26	0.9130	0.1010	0.0184	0.0650	0.137
0.2	1.58	0.9130	0.1010	0.0184	0.0650	0.137
0.3	2.00	0.9120	0.0995	0.0183	0.0637	0.135
0.4	2.51	0.8580	0.1050	0.0194	0.0667	0.143
0.5	3.16	0.8580	0.1050	0.0194	0.0667	0.143
0.6	3.98	0.8560	0.1030	0.0192	0.0653	0.141
0.7	5.01	0.8330	0.1040	0.0199	0.0655	0.143
0.8	6.31	0.7950	0.1070	0.0205	0.0673	0.148
0.9	7.94	0.7910	0.1030	0.0200	0.0641	0.143
1.0	10.00	0.7840	0.0950	0.0190	0.0578	0.132
1.1	12.60	0.7840	0.0950	0.0190	0.0578	0.132
1.2	15.80	0.7340	0.1060	0.0215	0.0640	0.148
1.3	20.00	0.6930	0.1250	0.0252	0.0758	0.174
1.4	25.10	0.6550	0.1370	0.0284	0.0818	0.193
1.5	31.60	0.5710	0.1520	0.0349	0.0838	0.221
1.6	39.80	0.5370	0.1430	0.0316	0.0812	0.205
1.7	50.10	0.4730	0.1460	0.0322	0.0826	0.209
1.8	63.10	0.4460	0.1460	0.0336	0.0803	0.212
1.9	79.40	0.4100	0.1530	0.0396	0.0758	0.231
2.0	100.00	0.3940	0.1820	0.0430	0.0976	0.266
2.1	126.00	0.3730	0.1960	0.0468	0.1040	0.288
2.2	158.00	0.3250	0.2210	0.0544	0.1150	0.328
2.3	200.00	0.2920	0.2220	0.0529	0.1180	0.326
2.4	251.00	0.2150	0.3310	0.0812	0.1710	0.490
2.5	316.00	0.2050	0.3180	0.0978	0.1270	0.510
2.6	398.00	0.1310	0.3330	0.0955	0.1460	0.520
2.7	501.00	0.1160	0.3550	0.1120	0.1370	0.574
2.8	631.00	0.0907	0.4560	0.1330	0.1950	0.718
2.9	794.00	0.0907	0.4560	0.1330	0.1950	0.718
3.0	1000.00	0.0630	0.6290	0.2440	0.1510	1.110
3.1	1260.00	0.0612	0.6340	0.2440	0.1550	1.110
3.2	1580.00	0.0578	0.6370	0.2500	0.1480	1.130
3.3	2000.00	0.0335	0.6230	0.2210	0.1900	1.060
3.4	2510.00	0.0318	0.6060	0.2270	0.1610	1.050
3.5	3160.00	0.0156	0.5760	0.2810	0.0248	1.130
3.6	3980.00	0.0156	0.5760	0.2810	0.0248	1.130
3.7	5010.00	0.0156	0.5760	0.2810	0.0248	1.130
3.8	6310.00	0.0156	0.5760	0.2810	0.0248	1.130

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	-0.87	0.302	-1.46	-0.2780
0.1	0.9130	1.26	-0.87	0.346	-1.55	-0.1920
0.2	0.9130	1.58	-0.87	0.346	-1.55	-0.1920
0.3	0.9120	2.00	-0.87	0.345	-1.55	-0.1950
0.4	0.8580	2.51	-0.87	0.354	-1.56	-0.1770
0.5	0.8580	3.16	-0.87	0.354	-1.56	-0.1770
0.6	0.8560	3.98	-0.87	0.352	-1.56	-0.1800
0.7	0.8330	5.01	-0.87	0.357	-1.57	-0.1700
0.8	0.7950	6.31	-0.87	0.363	-1.58	-0.1590
0.9	0.7910	7.94	-0.87	0.359	-1.57	-0.1670
1.0	0.7840	10.00	-0.87	0.350	-1.56	-0.1840
1.1	0.7840	12.60	-0.87	0.350	-1.56	-0.1840
1.2	0.7340	15.80	-0.87	0.371	-1.60	-0.1430
1.3	0.6930	20.00	-0.87	0.404	-1.66	-0.0790
1.4	0.6550	25.10	-0.87	0.434	-1.72	-0.0197
1.5	0.5710	31.60	-0.87	0.499	-1.85	0.1080
1.6	0.5370	39.80	-0.87	0.465	-1.78	0.0418
1.7	0.4730	50.10	-0.87	0.472	-1.80	0.0545
1.8	0.4460	63.10	-0.87	0.486	-1.82	0.0829
1.9	0.4100	79.40	-0.87	0.549	-1.95	0.2050
2.0	0.3940	100.00	-0.87	0.585	-2.02	0.2760
2.1	0.3730	126.00	-0.87	0.626	-2.10	0.3570
2.2	0.3250	158.00	-0.87	0.711	-2.26	0.5230
2.3	0.2920	200.00	-0.87	0.694	-2.23	0.4900
2.4	0.2150	251.00	-0.87	1.020	-2.87	1.1300
2.5	0.2050	316.00	-0.87	1.220	-3.25	1.5100
2.6	0.1310	398.00	-0.87	1.190	-3.20	1.4600
2.7	0.1160	501.00	-0.87	1.380	-3.58	1.8400
2.8	0.0907	631.00	-0.87	1.640	-4.09	2.3500
2.9	0.0907	794.00	-0.87	1.640	-4.09	2.3500
3.0	0.0630	1000.00	-0.87	2.980	-6.71	4.9700
3.1	0.0612	1260.00	-0.87	2.980	-6.71	4.9700
3.2	0.0578	1580.00	-0.87	3.040	-6.83	5.0900
3.3	0.0335	2000.00	-0.87	2.690	-6.15	4.4100
3.4	0.0318	2510.00	-0.87	2.780	-6.31	4.5700
3.5	0.0156	3160.00	-0.87	3.420	-7.58	5.8400
3.6	0.0156	3980.00	-0.87	3.420	-7.58	5.8400
3.7	0.0156	5010.00	-0.87	3.420	-7.58	5.8400
3.8	0.0156	6310.00	-0.87	3.420	-7.58	5.8400

IgG3 V1V2 C.1086-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.171	0.0122	0.1470	0.195
0.1	0.9000	1.26	0.171	0.0165	0.1390	0.204
0.2	0.8900	1.58	0.171	0.0170	0.1380	0.205
0.3	0.8900	2.00	0.171	0.0170	0.1380	0.205
0.4	0.8610	2.51	0.171	0.0179	0.1360	0.206
0.5	0.8430	3.16	0.171	0.0175	0.1370	0.206
0.6	0.8140	3.98	0.171	0.0189	0.1340	0.208
0.7	0.7960	5.01	0.171	0.0195	0.1330	0.209
0.8	0.7320	6.31	0.171	0.0212	0.1300	0.213
0.9	0.7070	7.94	0.171	0.0236	0.1250	0.217
1.0	0.6880	10.00	0.171	0.0250	0.1220	0.220
1.1	0.6240	12.60	0.171	0.0279	0.1170	0.226
1.2	0.5730	15.80	0.171	0.0268	0.1190	0.224
1.3	0.5170	20.00	0.171	0.0256	0.1210	0.221
1.4	0.4800	25.10	0.171	0.0284	0.1150	0.227
1.5	0.4400	31.60	0.171	0.0330	0.1070	0.236
1.6	0.4190	39.80	0.171	0.0385	0.0958	0.247
1.7	0.3860	50.10	0.171	0.0448	0.0833	0.259
1.8	0.3510	63.10	0.171	0.0455	0.0821	0.260
1.9	0.3020	79.40	0.171	0.0564	0.0606	0.282
2.0	0.2350	100.00	0.171	0.1290	-0.0821	0.424
2.1	0.1480	126.00	0.171	0.1050	-0.0345	0.377
2.2	0.1220	158.00	0.171	0.1010	-0.0267	0.369
2.3	0.1030	200.00	0.171	0.1170	-0.0584	0.401
2.4	0.0924	251.00	0.171	0.1270	-0.0777	0.420
2.5	0.0681	316.00	0.171	0.2300	-0.2790	0.621
2.6	0.0646	398.00	0.171	0.2370	-0.2930	0.635
2.7	0.0403	501.00	0.171	0.2400	-0.2990	0.641
2.8	0.0352	631.00	0.171	0.2540	-0.3270	0.670
2.9	0.0335	794.00	0.171	0.2620	-0.3420	0.684
3.0	0.0173	1000.00	0.171	0.2650	-0.3490	0.691
3.1	0.0156	1260.00	0.171	0.2810	-0.3800	0.722
3.2	0.0156	1580.00	0.171	0.2810	-0.3800	0.722
3.3	0.0156	2000.00	0.171	0.2810	-0.3800	0.722

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.0952	0.0122	0.0648	0.130
0.1	1.26	0.9000	0.0893	0.0165	0.0569	0.122
0.2	1.58	0.8900	0.0913	0.0170	0.0580	0.125
0.3	2.00	0.8900	0.0913	0.0170	0.0580	0.125
0.4	2.51	0.8610	0.0954	0.0179	0.0603	0.130
0.5	3.16	0.8430	0.0920	0.0175	0.0576	0.126
0.6	3.98	0.8140	0.0985	0.0189	0.0614	0.136
0.7	5.01	0.7960	0.1000	0.0195	0.0618	0.138
0.8	6.31	0.7320	0.1060	0.0212	0.0642	0.147
0.9	7.94	0.7070	0.1160	0.0236	0.0694	0.162
1.0	10.00	0.6880	0.1220	0.0250	0.0731	0.171
1.1	12.60	0.6240	0.1310	0.0279	0.0766	0.186
1.2	15.80	0.5730	0.1260	0.0268	0.0732	0.178
1.3	20.00	0.5170	0.1160	0.0256	0.0658	0.166
1.4	25.10	0.4800	0.1230	0.0284	0.0673	0.179
1.5	31.60	0.4400	0.1320	0.0330	0.0676	0.197
1.6	39.80	0.4190	0.1520	0.0385	0.0770	0.228
1.7	50.10	0.3860	0.1970	0.0448	0.1100	0.285
1.8	63.10	0.3510	0.1990	0.0455	0.1100	0.288
1.9	79.40	0.3020	0.2320	0.0564	0.1220	0.343
2.0	100.00	0.2350	0.3880	0.1290	0.1350	0.641
2.1	126.00	0.1480	0.3940	0.1050	0.1880	0.600
2.2	158.00	0.1220	0.3610	0.1010	0.1630	0.559
2.3	200.00	0.1030	0.4030	0.1170	0.1730	0.633
2.4	251.00	0.0924	0.4460	0.1270	0.1970	0.695
2.5	316.00	0.0681	0.6540	0.2300	0.2040	1.100
2.6	398.00	0.0646	0.6470	0.2370	0.1830	1.110
2.7	501.00	0.0403	0.7550	0.2400	0.2850	1.230
2.8	631.00	0.0352	0.7180	0.2540	0.2190	1.220
2.9	794.00	0.0335	0.7030	0.2620	0.1900	1.220
3.0	1000.00	0.0173	0.6110	0.2650	0.0910	1.130
3.1	1260.00	0.0156	0.5760	0.2810	0.0248	1.130
3.2	1580.00	0.0156	0.5760	0.2810	0.0248	1.130
3.3	2000.00	0.0156	0.5760	0.2810	0.0248	1.130

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	-1.08	0.328	-1.72	-0.43600
0.1	0.9000	1.26	-1.08	0.355	-1.78	-0.38300
0.2	0.8900	1.58	-1.08	0.359	-1.78	-0.37700
0.3	0.8900	2.00	-1.08	0.359	-1.78	-0.37700
0.4	0.8610	2.51	-1.08	0.365	-1.79	-0.36400
0.5	0.8430	3.16	-1.08	0.362	-1.79	-0.37000
0.6	0.8140	3.98	-1.08	0.373	-1.81	-0.34900
0.7	0.7960	5.01	-1.08	0.377	-1.82	-0.34000
0.8	0.7320	6.31	-1.08	0.390	-1.84	-0.31400
0.9	0.7070	7.94	-1.08	0.410	-1.88	-0.27600
1.0	0.6880	10.00	-1.08	0.422	-1.91	-0.25200
1.1	0.6240	12.60	-1.08	0.448	-1.96	-0.20200
1.2	0.5730	15.80	-1.08	0.438	-1.94	-0.22100
1.3	0.5170	20.00	-1.08	0.428	-1.92	-0.24100
1.4	0.4800	25.10	-1.08	0.453	-1.97	-0.19200
1.5	0.4400	31.60	-1.08	0.496	-2.05	-0.10700
1.6	0.4190	39.80	-1.08	0.551	-2.16	0.00141
1.7	0.3860	50.10	-1.08	0.619	-2.29	0.13300
1.8	0.3510	63.10	-1.08	0.625	-2.31	0.14600
1.9	0.3020	79.40	-1.08	0.745	-2.54	0.38100
2.0	0.2350	100.00	-1.08	1.600	-4.21	2.05000
2.1	0.1480	126.00	-1.08	1.310	-3.64	1.48000
2.2	0.1220	158.00	-1.08	1.260	-3.55	1.39000
2.3	0.1030	200.00	-1.08	1.450	-3.93	1.77000
2.4	0.0924	251.00	-1.08	1.570	-4.16	2.00000
2.5	0.0681	316.00	-1.08	2.800	-6.58	4.42000
2.6	0.0646	398.00	-1.08	2.890	-6.75	4.59000
2.7	0.0403	501.00	-1.08	2.930	-6.82	4.66000
2.8	0.0352	631.00	-1.08	3.100	-7.16	5.00000
2.9	0.0335	794.00	-1.08	3.190	-7.34	5.18000
3.0	0.0173	1000.00	-1.08	3.240	-7.42	5.26000
3.1	0.0156	1260.00	-1.08	3.430	-7.80	5.64000
3.2	0.0156	1580.00	-1.08	3.430	-7.80	5.64000
3.3	0.0156	2000.00	-1.08	3.430	-7.80	5.64000

IgG3 V1V2 C.1086-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.162	0.0122	0.1380	0.186
0.1	0.6850	1.26	0.162	0.0227	0.1180	0.207
0.2	0.6850	1.58	0.162	0.0227	0.1180	0.207
0.3	0.6830	2.00	0.162	0.0225	0.1180	0.206
0.4	0.6830	2.51	0.162	0.0225	0.1180	0.206
0.5	0.6580	3.16	0.162	0.0238	0.1160	0.209
0.6	0.6420	3.98	0.162	0.0248	0.1140	0.211
0.7	0.6420	5.01	0.162	0.0248	0.1140	0.211
0.8	0.6400	6.31	0.162	0.0245	0.1140	0.210
0.9	0.6400	7.94	0.162	0.0245	0.1140	0.210
1.0	0.6260	10.00	0.162	0.0263	0.1110	0.214
1.1	0.6030	12.60	0.162	0.0284	0.1070	0.218
1.2	0.6000	15.80	0.162	0.0278	0.1080	0.217
1.3	0.5850	20.00	0.162	0.0294	0.1050	0.220
1.4	0.5600	25.10	0.162	0.0302	0.1030	0.221
1.5	0.5360	31.60	0.162	0.0332	0.0972	0.227
1.6	0.4890	39.80	0.162	0.0403	0.0832	0.241
1.7	0.4860	50.10	0.162	0.0396	0.0846	0.240
1.8	0.4860	63.10	0.162	0.0396	0.0846	0.240
1.9	0.4610	79.40	0.162	0.0432	0.0776	0.247
2.0	0.4260	100.00	0.162	0.0397	0.0844	0.240
2.1	0.3420	126.00	0.162	0.0440	0.0760	0.248
2.2	0.3410	158.00	0.162	0.0435	0.0770	0.247
2.3	0.3370	200.00	0.162	0.0426	0.0787	0.246
2.4	0.2950	251.00	0.162	0.0528	0.0587	0.266
2.5	0.2940	316.00	0.162	0.0526	0.0592	0.265
2.6	0.2550	398.00	0.162	0.0545	0.0554	0.269
2.7	0.2270	501.00	0.162	0.0738	0.0175	0.307
2.8	0.1880	631.00	0.162	0.0960	-0.0259	0.350
2.9	0.1370	794.00	0.162	0.0945	-0.0229	0.347
3.0	0.0995	1000.00	0.162	0.1200	-0.0721	0.397
3.1	0.0977	1260.00	0.162	0.1270	-0.0862	0.411
3.2	0.0872	1580.00	0.162	0.1390	-0.1100	0.435
3.3	0.0629	2000.00	0.162	0.2420	-0.3110	0.636
3.4	0.0612	2510.00	0.162	0.2470	-0.3210	0.646
3.5	0.0369	3160.00	0.162	0.2540	-0.3350	0.660
3.6	0.0335	3980.00	0.162	0.2620	-0.3510	0.676
3.7	0.0317	5010.00	0.162	0.2700	-0.3670	0.692
3.8	0.0317	6310.00	0.162	0.2700	-0.3670	0.692
3.9	0.0156	7940.00	0.162	0.2810	-0.3890	0.713
4.0	0.0156	10000.00	0.162	0.2810	-0.3890	0.713
4.1	0.0156	12600.00	0.162	0.2810	-0.3890	0.713

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.0952	0.0122	0.0648	0.130
0.1	1.26	0.6850	0.1110	0.0227	0.0665	0.156
0.2	1.58	0.6850	0.1110	0.0227	0.0665	0.156
0.3	2.00	0.6830	0.1090	0.0225	0.0649	0.153
0.4	2.51	0.6830	0.1090	0.0225	0.0649	0.153
0.5	3.16	0.6580	0.1140	0.0238	0.0676	0.161
0.6	3.98	0.6420	0.1170	0.0248	0.0685	0.166
0.7	5.01	0.6420	0.1170	0.0248	0.0685	0.166
0.8	6.31	0.6400	0.1150	0.0245	0.0669	0.163
0.9	7.94	0.6400	0.1150	0.0245	0.0669	0.163
1.0	10.00	0.6260	0.1220	0.0263	0.0708	0.174
1.1	12.60	0.6030	0.1280	0.0284	0.0727	0.184
1.2	15.80	0.6000	0.1240	0.0278	0.0692	0.178
1.3	20.00	0.5850	0.1300	0.0294	0.0724	0.187
1.4	25.10	0.5600	0.1310	0.0302	0.0724	0.191
1.5	31.60	0.5360	0.1380	0.0332	0.0725	0.203
1.6	39.80	0.4890	0.1640	0.0403	0.0846	0.243
1.7	50.10	0.4860	0.1580	0.0396	0.0800	0.235
1.8	63.10	0.4860	0.1580	0.0396	0.0800	0.235
1.9	79.40	0.4610	0.1670	0.0432	0.0828	0.252
2.0	100.00	0.4260	0.1600	0.0397	0.0825	0.238
2.1	126.00	0.3420	0.1760	0.0440	0.0894	0.262
2.2	158.00	0.3410	0.1690	0.0435	0.0841	0.255
2.3	200.00	0.3370	0.1640	0.0426	0.0802	0.247
2.4	251.00	0.2950	0.2300	0.0528	0.1260	0.333
2.5	316.00	0.2940	0.2260	0.0526	0.1230	0.329
2.6	398.00	0.2550	0.2230	0.0545	0.1160	0.330
2.7	501.00	0.2270	0.3110	0.0738	0.1660	0.456
2.8	631.00	0.1880	0.3280	0.0960	0.1400	0.516
2.9	794.00	0.1370	0.3000	0.0945	0.1150	0.486
3.0	1000.00	0.0995	0.3730	0.1200	0.1390	0.608
3.1	1260.00	0.0977	0.3760	0.1270	0.1280	0.625
3.2	1580.00	0.0872	0.4340	0.1390	0.1620	0.707
3.3	2000.00	0.0629	0.6380	0.2420	0.1650	1.110
3.4	2510.00	0.0612	0.6300	0.2470	0.1470	1.110
3.5	3160.00	0.0369	0.7250	0.2540	0.2280	1.220
3.6	3980.00	0.0335	0.7030	0.2620	0.1900	1.220
3.7	5010.00	0.0317	0.6880	0.2700	0.1580	1.220
3.8	6310.00	0.0317	0.6880	0.2700	0.1580	1.220
3.9	7940.00	0.0156	0.5760	0.2810	0.0248	1.130
4.0	10000.00	0.0156	0.5760	0.2810	0.0248	1.130
4.1	12600.00	0.0156	0.5760	0.2810	0.0248	1.130

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	-0.971	0.315	-1.59	-0.3540
0.1	0.6850	1.26	-0.971	0.392	-1.74	-0.2030
0.2	0.6850	1.58	-0.971	0.392	-1.74	-0.2030
0.3	0.6830	2.00	-0.971	0.390	-1.73	-0.2060
0.4	0.6830	2.51	-0.971	0.390	-1.73	-0.2060
0.5	0.6580	3.16	-0.971	0.401	-1.76	-0.1850
0.6	0.6420	3.98	-0.971	0.410	-1.77	-0.1680
0.7	0.6420	5.01	-0.971	0.410	-1.77	-0.1680
0.8	0.6400	6.31	-0.971	0.407	-1.77	-0.1720
0.9	0.6400	7.94	-0.971	0.407	-1.77	-0.1720
1.0	0.6260	10.00	-0.971	0.423	-1.80	-0.1420
1.1	0.6030	12.60	-0.971	0.443	-1.84	-0.1020
1.2	0.6000	15.80	-0.971	0.437	-1.83	-0.1140
1.3	0.5850	20.00	-0.971	0.452	-1.86	-0.0845
1.4	0.5600	25.10	-0.971	0.460	-1.87	-0.0697
1.5	0.5360	31.60	-0.971	0.490	-1.93	-0.0109
1.6	0.4890	39.80	-0.971	0.563	-2.07	0.1330
1.7	0.4860	50.10	-0.971	0.556	-2.06	0.1180
1.8	0.4860	63.10	-0.971	0.556	-2.06	0.1180
1.9	0.4610	79.40	-0.971	0.593	-2.13	0.1920
2.0	0.4260	100.00	-0.971	0.556	-2.06	0.1200
2.1	0.3420	126.00	-0.971	0.602	-2.15	0.2100
2.2	0.3410	158.00	-0.971	0.597	-2.14	0.1990
2.3	0.3370	200.00	-0.971	0.588	-2.12	0.1810
2.4	0.2950	251.00	-0.971	0.699	-2.34	0.4000
2.5	0.2940	316.00	-0.971	0.696	-2.34	0.3940
2.6	0.2550	398.00	-0.971	0.718	-2.38	0.4370
2.7	0.2270	501.00	-0.971	0.939	-2.81	0.8700
2.8	0.1880	631.00	-0.971	1.200	-3.32	1.3800
2.9	0.1370	794.00	-0.971	1.180	-3.29	1.3400
3.0	0.0995	1000.00	-0.971	1.480	-3.87	1.9300
3.1	0.0977	1260.00	-0.971	1.560	-4.04	2.1000
3.2	0.0872	1580.00	-0.971	1.710	-4.33	2.3900
3.3	0.0629	2000.00	-0.971	2.950	-6.75	4.8100
3.4	0.0612	2510.00	-0.971	3.010	-6.87	4.9300
3.5	0.0369	3160.00	-0.971	3.100	-7.04	5.1000
3.6	0.0335	3980.00	-0.971	3.190	-7.23	5.2900
3.7	0.0317	5010.00	-0.971	3.290	-7.43	5.4900
3.8	0.0317	6310.00	-0.971	3.290	-7.43	5.4900
3.9	0.0156	7940.00	-0.971	3.430	-7.68	5.7400
4.0	0.0156	10000.00	-0.971	3.430	-7.68	5.7400
4.1	0.0156	12600.00	-0.971	3.430	-7.68	5.7400

HVTN 505

• Adjustment covariates: age, racecc, BMI, bhvrisk
• Event time variable: HIVwk28preunblfu
• Event type variable: HIVwk28preunbl
• Weight variable: weight
• Reference timepoint: 514 days
• All learners: GLM

IgG V1V2 B.CaseA-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.0913	0.0174	0.057100	0.125
0.1	0.282	1.26	0.0570	0.0238	0.010400	0.104
0.2	0.282	1.58	0.0570	0.0238	0.010400	0.104
0.3	0.282	2.00	0.0570	0.0238	0.010400	0.104
0.4	0.273	2.51	0.0570	0.0248	0.008420	0.106
0.5	0.273	3.16	0.0570	0.0248	0.008420	0.106
0.6	0.273	3.98	0.0570	0.0248	0.008420	0.106
0.7	0.253	5.01	0.0570	0.0258	0.006380	0.108
0.8	0.253	6.31	0.0570	0.0258	0.006380	0.108
0.9	0.253	7.94	0.0570	0.0258	0.006380	0.108
1.0	0.248	10.00	0.0570	0.0271	0.003900	0.110
1.1	0.236	12.60	0.0570	0.0286	0.000932	0.113
1.2	0.236	15.80	0.0570	0.0286	0.000932	0.113
1.3	0.236	20.00	0.0570	0.0286	0.000932	0.113
1.4	0.211	25.10	0.0570	0.0317	-0.005170	0.119
1.5	0.207	31.60	0.0570	0.0332	-0.008050	0.122
1.6	0.207	39.80	0.0570	0.0332	-0.008050	0.122
1.7	0.207	50.10	0.0570	0.0332	-0.008050	0.122
1.8	0.196	63.10	0.0570	0.0349	-0.011500	0.125
1.9	0.182	79.40	0.0570	0.0387	-0.018900	0.133
2.0	0.173	100.00	0.0570	0.0391	-0.019600	0.134
2.1	0.141	126.00	0.0570	0.0455	-0.032100	0.146

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.0913	0.0174	0.049500	0.1220
0.1	1.26	0.282	0.0464	0.0238	-0.000179	0.0930
0.2	1.58	0.282	0.0464	0.0238	-0.000179	0.0930
0.3	2.00	0.282	0.0464	0.0238	-0.000179	0.0930
0.4	2.51	0.273	0.0476	0.0248	-0.000919	0.0962
0.5	3.16	0.273	0.0476	0.0248	-0.000919	0.0962
0.6	3.98	0.273	0.0476	0.0248	-0.000919	0.0962
0.7	5.01	0.253	0.0493	0.0258	-0.001260	0.0999
0.8	6.31	0.253	0.0493	0.0258	-0.001260	0.0999
0.9	7.94	0.253	0.0493	0.0258	-0.001260	0.0999
1.0	10.00	0.248	0.0541	0.0271	0.001060	0.1070
1.1	12.60	0.236	0.0557	0.0286	-0.000311	0.1120
1.2	15.80	0.236	0.0557	0.0286	-0.000311	0.1120
1.3	20.00	0.236	0.0557	0.0286	-0.000311	0.1120
1.4	25.10	0.211	0.0619	0.0317	-0.000237	0.1240
1.5	31.60	0.207	0.0662	0.0332	0.001180	0.1310
1.6	39.80	0.207	0.0662	0.0332	0.001180	0.1310
1.7	50.10	0.207	0.0662	0.0332	0.001180	0.1310
1.8	63.10	0.196	0.0696	0.0349	0.001200	0.1380
1.9	79.40	0.182	0.0689	0.0387	-0.006920	0.1450
2.0	100.00	0.173	0.0700	0.0391	-0.006530	0.1470
2.1	126.00	0.141	0.0758	0.0455	-0.013300	0.1650

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	-0.319	0.387	-1.080	0.439
0.1	0.282	1.26	0.177	0.389	-0.586	0.940
0.2	0.282	1.58	0.177	0.389	-0.586	0.940
0.3	0.282	2.00	0.177	0.389	-0.586	0.940
0.4	0.273	2.51	0.177	0.402	-0.611	0.965
0.5	0.273	3.16	0.177	0.402	-0.611	0.965
0.6	0.273	3.98	0.177	0.402	-0.611	0.965
0.7	0.253	5.01	0.177	0.415	-0.637	0.991
0.8	0.253	6.31	0.177	0.415	-0.637	0.991
0.9	0.253	7.94	0.177	0.415	-0.637	0.991
1.0	0.248	10.00	0.177	0.432	-0.670	1.020
1.1	0.236	12.60	0.177	0.452	-0.709	1.060
1.2	0.236	15.80	0.177	0.452	-0.709	1.060
1.3	0.236	20.00	0.177	0.452	-0.709	1.060
1.4	0.211	25.10	0.177	0.493	-0.790	1.140
1.5	0.207	31.60	0.177	0.513	-0.829	1.180
1.6	0.207	39.80	0.177	0.513	-0.829	1.180
1.7	0.207	50.10	0.177	0.513	-0.829	1.180
1.8	0.196	63.10	0.177	0.537	-0.875	1.230
1.9	0.182	79.40	0.177	0.588	-0.976	1.330
2.0	0.173	100.00	0.177	0.593	-0.986	1.340
2.1	0.141	126.00	0.177	0.682	-1.160	1.510

IgG V1V2 AE.A244-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.0913	0.0174	0.05710	0.125
0.1	0.641	1.26	0.0888	0.0219	0.04580	0.132
0.2	0.633	1.58	0.0888	0.0223	0.04520	0.132
0.3	0.633	2.00	0.0888	0.0223	0.04520	0.132
0.4	0.626	2.51	0.0888	0.0228	0.04410	0.133
0.5	0.626	3.16	0.0888	0.0228	0.04410	0.133
0.6	0.622	3.98	0.0888	0.0232	0.04340	0.134
0.7	0.614	5.01	0.0888	0.0231	0.04350	0.134
0.8	0.594	6.31	0.0888	0.0238	0.04220	0.135
0.9	0.581	7.94	0.0888	0.0247	0.04040	0.137
1.0	0.570	10.00	0.0888	0.0251	0.03960	0.138
1.1	0.558	12.60	0.0888	0.0251	0.03950	0.138
1.2	0.554	15.80	0.0888	0.0254	0.03900	0.139
1.3	0.534	20.00	0.0888	0.0258	0.03820	0.139
1.4	0.502	25.10	0.0888	0.0262	0.03750	0.140
1.5	0.482	31.60	0.0888	0.0264	0.03700	0.141
1.6	0.441	39.80	0.0888	0.0293	0.03130	0.146
1.7	0.430	50.10	0.0888	0.0305	0.02890	0.149
1.8	0.408	63.10	0.0888	0.0316	0.02690	0.151
1.9	0.380	79.40	0.0888	0.0330	0.02410	0.154
2.0	0.355	100.00	0.0888	0.0333	0.02350	0.154
2.1	0.305	126.00	0.0888	0.0356	0.01890	0.159
2.2	0.264	158.00	0.0888	0.0362	0.01780	0.160
2.3	0.237	200.00	0.0846	0.0310	0.02380	0.145
2.4	0.225	251.00	0.0846	0.0336	0.01880	0.150
2.5	0.210	316.00	0.0846	0.0344	0.01710	0.152
2.6	0.178	398.00	0.0846	0.0384	0.00920	0.160
2.7	0.151	501.00	0.0846	0.0473	-0.00821	0.177
2.8	0.139	631.00	0.0846	0.0518	-0.01710	0.186
2.9	0.135	794.00	0.0846	0.0570	-0.02720	0.196
3.0	0.114	1000.00	0.0846	0.0643	-0.04150	0.211
3.1	0.103	1260.00	0.0846	0.0639	-0.04070	0.210

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.0913	0.0174	0.05170	0.125
0.1	1.26	0.641	0.0788	0.0219	0.03580	0.122
0.2	1.58	0.633	0.0800	0.0223	0.03630	0.124
0.3	2.00	0.633	0.0800	0.0223	0.03630	0.124
0.4	2.51	0.626	0.0816	0.0228	0.03700	0.126
0.5	3.16	0.626	0.0816	0.0228	0.03700	0.126
0.6	3.98	0.622	0.0827	0.0232	0.03730	0.128
0.7	5.01	0.614	0.0826	0.0231	0.03720	0.128
0.8	6.31	0.594	0.0848	0.0238	0.03820	0.131
0.9	7.94	0.581	0.0888	0.0247	0.04040	0.137
1.0	10.00	0.570	0.0902	0.0251	0.04100	0.139
1.1	12.60	0.558	0.0902	0.0251	0.04100	0.140
1.2	15.80	0.554	0.0912	0.0254	0.04140	0.141
1.3	20.00	0.534	0.0922	0.0258	0.04150	0.143
1.4	25.10	0.502	0.0898	0.0262	0.03850	0.141
1.5	31.60	0.482	0.0866	0.0264	0.03480	0.138
1.6	39.80	0.441	0.0966	0.0293	0.03910	0.154
1.7	50.10	0.430	0.1010	0.0305	0.04080	0.161
1.8	63.10	0.408	0.0992	0.0316	0.03730	0.161
1.9	79.40	0.380	0.1050	0.0330	0.04000	0.169
2.0	100.00	0.355	0.1070	0.0333	0.04140	0.172
2.1	126.00	0.305	0.1090	0.0356	0.03920	0.179
2.2	158.00	0.264	0.0965	0.0362	0.02540	0.167
2.3	200.00	0.237	0.0633	0.0310	0.00250	0.124
2.4	251.00	0.225	0.0687	0.0336	0.00294	0.135
2.5	316.00	0.210	0.0603	0.0344	-0.00722	0.128
2.6	398.00	0.178	0.0660	0.0384	-0.00940	0.141
2.7	501.00	0.151	0.0864	0.0473	-0.00631	0.179
2.8	631.00	0.139	0.0926	0.0518	-0.00901	0.194
2.9	794.00	0.135	0.1000	0.0570	-0.01140	0.212
3.0	1000.00	0.114	0.1120	0.0643	-0.01430	0.238
3.1	1260.00	0.103	0.1120	0.0639	-0.01360	0.237

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	-0.319	0.387	-1.08	0.439
0.1	0.641	1.26	-0.283	0.427	-1.12	0.553
0.2	0.633	1.58	-0.283	0.430	-1.13	0.560
0.3	0.633	2.00	-0.283	0.430	-1.13	0.560
0.4	0.626	2.51	-0.283	0.436	-1.14	0.571
0.5	0.626	3.16	-0.283	0.436	-1.14	0.571
0.6	0.622	3.98	-0.283	0.440	-1.15	0.579
0.7	0.614	5.01	-0.283	0.440	-1.14	0.578
0.8	0.594	6.31	-0.283	0.447	-1.16	0.592
0.9	0.581	7.94	-0.283	0.457	-1.18	0.613
1.0	0.570	10.00	-0.283	0.461	-1.19	0.621
1.1	0.558	12.60	-0.283	0.462	-1.19	0.622
1.2	0.554	15.80	-0.283	0.465	-1.19	0.628
1.3	0.534	20.00	-0.283	0.470	-1.20	0.638
1.4	0.502	25.10	-0.283	0.474	-1.21	0.645
1.5	0.482	31.60	-0.283	0.477	-1.22	0.651
1.6	0.441	39.80	-0.283	0.511	-1.28	0.719
1.7	0.430	50.10	-0.283	0.526	-1.31	0.747
1.8	0.408	63.10	-0.283	0.538	-1.34	0.772
1.9	0.380	79.40	-0.283	0.556	-1.37	0.806
2.0	0.355	100.00	-0.283	0.560	-1.38	0.814
2.1	0.305	126.00	-0.283	0.589	-1.44	0.871
2.2	0.264	158.00	-0.283	0.596	-1.45	0.886
2.3	0.237	200.00	-0.222	0.524	-1.25	0.805
2.4	0.225	251.00	-0.222	0.556	-1.31	0.868
2.5	0.210	316.00	-0.222	0.567	-1.33	0.890
2.6	0.178	398.00	-0.222	0.618	-1.43	0.990
2.7	0.151	501.00	-0.222	0.736	-1.66	1.220
2.8	0.139	631.00	-0.222	0.797	-1.78	1.340
2.9	0.135	794.00	-0.222	0.867	-1.92	1.480
3.0	0.114	1000.00	-0.222	0.968	-2.12	1.680
3.1	0.103	1260.00	-0.222	0.963	-2.11	1.670

IgG V1V2 C.1086-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.0913	0.0174	0.05710	0.125
0.1	0.672	1.26	0.0840	0.0220	0.04100	0.127
0.2	0.672	1.58	0.0840	0.0220	0.04100	0.127
0.3	0.666	2.00	0.0840	0.0226	0.03970	0.128
0.4	0.666	2.51	0.0840	0.0226	0.03970	0.128
0.5	0.662	3.16	0.0840	0.0232	0.03850	0.129
0.6	0.662	3.98	0.0840	0.0232	0.03850	0.129
0.7	0.653	5.01	0.0840	0.0234	0.03820	0.130
0.8	0.648	6.31	0.0840	0.0241	0.03670	0.131
0.9	0.648	7.94	0.0840	0.0241	0.03670	0.131
1.0	0.618	10.00	0.0840	0.0243	0.03640	0.132
1.1	0.601	12.60	0.0840	0.0253	0.03430	0.134
1.2	0.577	15.80	0.0775	0.0225	0.03330	0.122
1.3	0.541	20.00	0.0775	0.0237	0.03090	0.124
1.4	0.526	25.10	0.0775	0.0243	0.02980	0.125
1.5	0.498	31.60	0.0727	0.0238	0.02610	0.119
1.6	0.494	39.80	0.0656	0.0228	0.02100	0.110
1.7	0.462	50.10	0.0642	0.0218	0.02150	0.107
1.8	0.451	63.10	0.0642	0.0223	0.02060	0.108
1.9	0.408	79.40	0.0642	0.0227	0.01960	0.109
2.0	0.377	100.00	0.0642	0.0204	0.02420	0.104
2.1	0.353	126.00	0.0642	0.0224	0.02030	0.108
2.2	0.330	158.00	0.0642	0.0244	0.01640	0.112
2.3	0.318	200.00	0.0642	0.0273	0.01060	0.118
2.4	0.292	251.00	0.0642	0.0265	0.01210	0.116
2.5	0.276	316.00	0.0642	0.0282	0.00892	0.119
2.6	0.256	398.00	0.0642	0.0291	0.00707	0.121
2.7	0.227	501.00	0.0642	0.0373	-0.00889	0.137

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.0913	0.0174	0.05410	0.1280
0.1	1.26	0.672	0.0788	0.0220	0.03580	0.1220
0.2	1.58	0.672	0.0788	0.0220	0.03580	0.1220
0.3	2.00	0.666	0.0806	0.0226	0.03630	0.1250
0.4	2.51	0.666	0.0806	0.0226	0.03630	0.1250
0.5	3.16	0.662	0.0838	0.0232	0.03830	0.1290
0.6	3.98	0.662	0.0838	0.0232	0.03830	0.1290
0.7	5.01	0.653	0.0844	0.0234	0.03860	0.1300
0.8	6.31	0.648	0.0874	0.0241	0.04010	0.1350
0.9	7.94	0.648	0.0874	0.0241	0.04010	0.1350
1.0	10.00	0.618	0.0882	0.0243	0.04060	0.1360
1.1	12.60	0.601	0.0910	0.0253	0.04130	0.1410
1.2	15.80	0.577	0.0737	0.0225	0.02950	0.1180
1.3	20.00	0.541	0.0784	0.0237	0.03190	0.1250
1.4	25.10	0.526	0.0805	0.0243	0.03290	0.1280
1.5	31.60	0.498	0.0727	0.0238	0.02610	0.1190
1.6	39.80	0.494	0.0656	0.0228	0.02100	0.1100
1.7	50.10	0.462	0.0608	0.0218	0.01820	0.1030
1.8	63.10	0.451	0.0632	0.0223	0.01960	0.1070
1.9	79.40	0.408	0.0630	0.0227	0.01850	0.1080
2.0	100.00	0.377	0.0549	0.0204	0.01500	0.0949
2.1	126.00	0.353	0.0603	0.0224	0.01640	0.1040
2.2	158.00	0.330	0.0648	0.0244	0.01700	0.1130
2.3	200.00	0.318	0.0682	0.0273	0.01460	0.1220
2.4	251.00	0.292	0.0623	0.0265	0.01030	0.1140
2.5	316.00	0.276	0.0660	0.0282	0.01080	0.1210
2.6	398.00	0.256	0.0637	0.0291	0.00663	0.1210
2.7	501.00	0.227	0.0786	0.0373	0.00555	0.1520

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	-0.3190	0.387	-1.080	0.439
0.1	0.672	1.26	-0.2140	0.416	-1.030	0.603
0.2	0.672	1.58	-0.2140	0.416	-1.030	0.603
0.3	0.666	2.00	-0.2140	0.424	-1.040	0.617
0.4	0.666	2.51	-0.2140	0.424	-1.040	0.617
0.5	0.662	3.16	-0.2140	0.430	-1.060	0.630
0.6	0.662	3.98	-0.2140	0.430	-1.060	0.630
0.7	0.653	5.01	-0.2140	0.432	-1.060	0.633
0.8	0.648	6.31	-0.2140	0.441	-1.080	0.650
0.9	0.648	7.94	-0.2140	0.441	-1.080	0.650
1.0	0.618	10.00	-0.2140	0.443	-1.080	0.654
1.1	0.601	12.60	-0.2140	0.455	-1.110	0.678
1.2	0.577	15.80	-0.1190	0.410	-0.923	0.684
1.3	0.541	20.00	-0.1190	0.424	-0.949	0.711
1.4	0.526	25.10	-0.1190	0.430	-0.962	0.724
1.5	0.498	31.60	-0.0498	0.415	-0.863	0.764
1.6	0.494	39.80	0.0516	0.391	-0.714	0.818
1.7	0.462	50.10	0.0727	0.376	-0.664	0.810
1.8	0.451	63.10	0.0727	0.382	-0.676	0.821
1.9	0.408	79.40	0.0727	0.388	-0.687	0.833
2.0	0.377	100.00	0.0727	0.360	-0.632	0.777
2.1	0.353	126.00	0.0727	0.384	-0.680	0.825
2.2	0.330	158.00	0.0727	0.408	-0.728	0.873
2.3	0.318	200.00	0.0727	0.445	-0.800	0.946
2.4	0.292	251.00	0.0727	0.436	-0.781	0.926
2.5	0.276	316.00	0.0727	0.457	-0.822	0.968
2.6	0.256	398.00	0.0727	0.469	-0.846	0.992
2.7	0.227	501.00	0.0727	0.577	-1.060	1.200

IgG V1V2 C.1086-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.0913	0.0174	0.057100	0.1250
0.1	0.411	1.26	0.0530	0.0232	0.007610	0.0985
0.2	0.411	1.58	0.0530	0.0232	0.007610	0.0985
0.3	0.411	2.00	0.0530	0.0232	0.007610	0.0985
0.4	0.399	2.51	0.0530	0.0235	0.007000	0.0991
0.5	0.387	3.16	0.0530	0.0240	0.005930	0.1000
0.6	0.387	3.98	0.0530	0.0240	0.005930	0.1000
0.7	0.379	5.01	0.0530	0.0238	0.006340	0.0998
0.8	0.374	6.31	0.0530	0.0245	0.005000	0.1010
0.9	0.374	7.94	0.0530	0.0245	0.005000	0.1010
1.0	0.353	10.00	0.0530	0.0248	0.004360	0.1020
1.1	0.345	12.60	0.0530	0.0250	0.004010	0.1020
1.2	0.336	15.80	0.0530	0.0252	0.003740	0.1020
1.3	0.328	20.00	0.0530	0.0257	0.002770	0.1030
1.4	0.320	25.10	0.0510	0.0225	0.006780	0.0952
1.5	0.296	31.60	0.0510	0.0234	0.005180	0.0968
1.6	0.291	39.80	0.0510	0.0248	0.002460	0.0995
1.7	0.291	50.10	0.0510	0.0248	0.002460	0.0995
1.8	0.280	63.10	0.0510	0.0257	0.000605	0.1010
1.9	0.275	79.40	0.0510	0.0265	-0.000994	0.1030
2.0	0.258	100.00	0.0510	0.0277	-0.003390	0.1050
2.1	0.252	126.00	0.0510	0.0296	-0.007020	0.1090

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.0913	0.0174	0.049500	0.1220
0.1	1.26	0.411	0.0510	0.0232	0.005520	0.0964
0.2	1.58	0.411	0.0510	0.0232	0.005520	0.0964
0.3	2.00	0.411	0.0510	0.0232	0.005520	0.0964
0.4	2.51	0.399	0.0516	0.0235	0.005510	0.0976
0.5	3.16	0.387	0.0524	0.0240	0.005280	0.0995
0.6	3.98	0.387	0.0524	0.0240	0.005280	0.0995
0.7	5.01	0.379	0.0522	0.0238	0.005480	0.0989
0.8	6.31	0.374	0.0540	0.0245	0.005970	0.1020
0.9	7.94	0.374	0.0540	0.0245	0.005970	0.1020
1.0	10.00	0.353	0.0546	0.0248	0.005910	0.1030
1.1	12.60	0.345	0.0549	0.0250	0.005860	0.1040
1.2	15.80	0.336	0.0550	0.0252	0.005730	0.1040
1.3	20.00	0.328	0.0557	0.0257	0.005370	0.1060
1.4	25.10	0.320	0.0438	0.0225	-0.000362	0.0880
1.5	31.60	0.296	0.0452	0.0234	-0.000624	0.0910
1.6	39.80	0.291	0.0500	0.0248	0.001540	0.0986
1.7	50.10	0.291	0.0500	0.0248	0.001540	0.0986
1.8	63.10	0.280	0.0517	0.0257	0.001360	0.1020
1.9	79.40	0.275	0.0531	0.0265	0.001150	0.1050
2.0	100.00	0.258	0.0550	0.0277	0.000610	0.1090
2.1	126.00	0.252	0.0589	0.0296	0.000881	0.1170

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	-0.319	0.387	-1.080	0.439
0.1	0.411	1.26	0.234	0.376	-0.503	0.970
0.2	0.411	1.58	0.234	0.376	-0.503	0.970
0.3	0.411	2.00	0.234	0.376	-0.503	0.970
0.4	0.399	2.51	0.234	0.380	-0.511	0.978
0.5	0.387	3.16	0.234	0.387	-0.525	0.992
0.6	0.387	3.98	0.234	0.387	-0.525	0.992
0.7	0.379	5.01	0.234	0.384	-0.520	0.987
0.8	0.374	6.31	0.234	0.393	-0.537	1.000
0.9	0.374	7.94	0.234	0.393	-0.537	1.000
1.0	0.353	10.00	0.234	0.397	-0.545	1.010
1.1	0.345	12.60	0.234	0.400	-0.550	1.020
1.2	0.336	15.80	0.234	0.402	-0.553	1.020
1.3	0.328	20.00	0.234	0.408	-0.566	1.030
1.4	0.320	25.10	0.263	0.365	-0.451	0.978
1.5	0.296	31.60	0.263	0.375	-0.472	0.999
1.6	0.291	39.80	0.263	0.393	-0.507	1.030
1.7	0.291	50.10	0.263	0.393	-0.507	1.030
1.8	0.280	63.10	0.263	0.406	-0.532	1.060
1.9	0.275	79.40	0.263	0.417	-0.553	1.080
2.0	0.258	100.00	0.263	0.433	-0.585	1.110
2.1	0.252	126.00	0.263	0.458	-0.634	1.160

IgG3 V1V2 B.CaseA-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.0913	0.0174	0.05710	0.125
0.1	0.546	1.26	0.0811	0.0238	0.03450	0.128
0.2	0.514	1.58	0.0793	0.0223	0.03560	0.123
0.3	0.514	2.00	0.0793	0.0223	0.03560	0.123
0.4	0.446	2.51	0.0793	0.0253	0.02970	0.129
0.5	0.414	3.16	0.0793	0.0266	0.02710	0.132
0.6	0.375	3.98	0.0793	0.0298	0.02090	0.138
0.7	0.319	5.01	0.0793	0.0361	0.00854	0.150
0.8	0.306	6.31	0.0793	0.0385	0.00378	0.155
0.9	0.279	7.94	0.0793	0.0427	-0.00446	0.163
1.0	0.232	10.00	0.0793	0.0449	-0.00868	0.167
1.1	0.190	12.60	0.0793	0.0500	-0.01860	0.177
1.2	0.178	15.80	0.0793	0.0485	-0.01580	0.174
1.3	0.164	20.00	0.0793	0.0521	-0.02280	0.181
1.4	0.164	25.10	0.0793	0.0521	-0.02280	0.181
1.5	0.144	31.60	0.0793	0.0473	-0.01340	0.172

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.0913	0.0174	0.057400	0.133
0.1	1.26	0.546	0.0811	0.0238	0.034500	0.128
0.2	1.58	0.514	0.0732	0.0223	0.029400	0.117
0.3	2.00	0.514	0.0732	0.0223	0.029400	0.117
0.4	2.51	0.446	0.0783	0.0253	0.028600	0.128
0.5	3.16	0.414	0.0827	0.0266	0.030500	0.135
0.6	3.98	0.375	0.0907	0.0298	0.032200	0.149
0.7	5.01	0.319	0.1050	0.0361	0.034200	0.176
0.8	6.31	0.306	0.1120	0.0385	0.036000	0.187
0.9	7.94	0.279	0.1200	0.0427	0.036400	0.204
1.0	10.00	0.232	0.0954	0.0449	0.007410	0.183
1.1	12.60	0.190	0.1090	0.0500	0.011500	0.207
1.2	15.80	0.178	0.1090	0.0485	0.014000	0.204
1.3	20.00	0.164	0.1100	0.0521	0.007590	0.212
1.4	25.10	0.164	0.1100	0.0521	0.007590	0.212
1.5	31.60	0.144	0.0921	0.0473	-0.000628	0.185

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	-0.319	0.387	-1.080	0.439
0.1	0.546	1.26	-0.172	0.432	-1.020	0.674
0.2	0.514	1.58	-0.146	0.411	-0.952	0.660
0.3	0.514	2.00	-0.146	0.411	-0.952	0.660
0.4	0.446	2.51	-0.146	0.446	-1.020	0.728
0.5	0.414	3.16	-0.146	0.462	-1.050	0.759
0.6	0.375	3.98	-0.146	0.501	-1.130	0.835
0.7	0.319	5.01	-0.146	0.581	-1.280	0.992
0.8	0.306	6.31	-0.146	0.612	-1.350	1.050
0.9	0.279	7.94	-0.146	0.668	-1.460	1.160
1.0	0.232	10.00	-0.146	0.697	-1.510	1.220
1.1	0.190	12.60	-0.146	0.765	-1.650	1.350
1.2	0.178	15.80	-0.146	0.746	-1.610	1.320
1.3	0.164	20.00	-0.146	0.795	-1.700	1.410
1.4	0.164	25.10	-0.146	0.795	-1.700	1.410
1.5	0.144	31.60	-0.146	0.730	-1.580	1.280

IgG3 V1V2 AE.A244-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.0954	0.0174	0.06120	0.130
0.1	0.7520	1.26	0.0954	0.0215	0.05320	0.138
0.2	0.7340	1.58	0.0954	0.0212	0.05390	0.137
0.3	0.7160	2.00	0.0954	0.0218	0.05260	0.138
0.4	0.6720	2.51	0.0954	0.0223	0.05180	0.139
0.5	0.6570	3.16	0.0954	0.0231	0.05020	0.141
0.6	0.5980	3.98	0.0954	0.0244	0.04760	0.143
0.7	0.5530	5.01	0.0954	0.0258	0.04490	0.146
0.8	0.4920	6.31	0.0954	0.0294	0.03780	0.153
0.9	0.4360	7.94	0.0954	0.0348	0.02720	0.164
1.0	0.4060	10.00	0.0954	0.0380	0.02080	0.170
1.1	0.3560	12.60	0.0954	0.0351	0.02650	0.164
1.2	0.3200	15.80	0.0954	0.0393	0.01840	0.172
1.3	0.3120	20.00	0.0954	0.0371	0.02270	0.168
1.4	0.2610	25.10	0.0954	0.0322	0.03230	0.159
1.5	0.2500	31.60	0.0954	0.0330	0.03080	0.160
1.6	0.2100	39.80	0.0954	0.0399	0.01720	0.174
1.7	0.1680	50.10	0.0954	0.0509	-0.00436	0.195
1.8	0.1680	63.10	0.0954	0.0509	-0.00436	0.195
1.9	0.1260	79.40	0.0954	0.0668	-0.03550	0.226
2.0	0.1150	100.00	0.0954	0.0791	-0.05970	0.251
2.1	0.1110	126.00	0.0954	0.0813	-0.06390	0.255
2.2	0.0909	158.00	0.0954	0.0826	-0.06650	0.257
2.3	0.0796	200.00	0.0954	0.0842	-0.06970	0.261
2.4	0.0796	251.00	0.0954	0.0842	-0.06970	0.261

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.0913	0.0174	0.0560	0.130
0.1	1.26	0.7520	0.0872	0.0215	0.0450	0.129
0.2	1.58	0.7340	0.0838	0.0212	0.0423	0.125
0.3	2.00	0.7160	0.0856	0.0218	0.0428	0.128
0.4	2.51	0.6720	0.0827	0.0223	0.0391	0.126
0.5	3.16	0.6570	0.0851	0.0231	0.0400	0.130
0.6	3.98	0.5980	0.0877	0.0244	0.0400	0.136
0.7	5.01	0.5530	0.0932	0.0258	0.0428	0.144
0.8	6.31	0.4920	0.1080	0.0294	0.0501	0.165
0.9	7.94	0.4360	0.1280	0.0348	0.0601	0.196
1.0	10.00	0.4060	0.1330	0.0380	0.0586	0.208
1.1	12.60	0.3560	0.0948	0.0351	0.0259	0.164
1.2	15.80	0.3200	0.0986	0.0393	0.0215	0.176
1.3	20.00	0.3120	0.0995	0.0371	0.0268	0.172
1.4	25.10	0.2610	0.0878	0.0322	0.0246	0.151
1.5	31.60	0.2500	0.0861	0.0330	0.0215	0.151
1.6	39.80	0.2100	0.1080	0.0399	0.0301	0.186
1.7	50.10	0.1680	0.1420	0.0509	0.0421	0.242
1.8	63.10	0.1680	0.1420	0.0509	0.0421	0.242
1.9	79.40	0.1260	0.1780	0.0668	0.0472	0.309
2.0	100.00	0.1150	0.2070	0.0791	0.0521	0.362
2.1	126.00	0.1110	0.1910	0.0813	0.0313	0.350
2.2	158.00	0.0909	0.1930	0.0826	0.0311	0.355
2.3	200.00	0.0796	0.2870	0.0842	0.1220	0.452
2.4	251.00	0.0796	0.2870	0.0842	0.1220	0.452

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	-0.378	0.397	-1.16	0.400
0.1	0.7520	1.26	-0.378	0.436	-1.23	0.477
0.2	0.7340	1.58	-0.378	0.433	-1.23	0.470
0.3	0.7160	2.00	-0.378	0.440	-1.24	0.484
0.4	0.6720	2.51	-0.378	0.444	-1.25	0.492
0.5	0.6570	3.16	-0.378	0.453	-1.27	0.509
0.6	0.5980	3.98	-0.378	0.467	-1.29	0.537
0.7	0.5530	5.01	-0.378	0.482	-1.32	0.567
0.8	0.4920	6.31	-0.378	0.524	-1.40	0.648
0.9	0.4360	7.94	-0.378	0.589	-1.53	0.776
1.0	0.4060	10.00	-0.378	0.629	-1.61	0.855
1.1	0.3560	12.60	-0.378	0.593	-1.54	0.784
1.2	0.3200	15.80	-0.378	0.645	-1.64	0.886
1.3	0.3120	20.00	-0.378	0.617	-1.59	0.832
1.4	0.2610	25.10	-0.378	0.557	-1.47	0.714
1.5	0.2500	31.60	-0.378	0.566	-1.49	0.732
1.6	0.2100	39.80	-0.378	0.653	-1.66	0.902
1.7	0.1680	50.10	-0.378	0.797	-1.94	1.180
1.8	0.1680	63.10	-0.378	0.797	-1.94	1.180
1.9	0.1260	79.40	-0.378	1.010	-2.36	1.610
2.0	0.1150	100.00	-0.378	1.180	-2.70	1.940
2.1	0.1110	126.00	-0.378	1.210	-2.76	2.000
2.2	0.0909	158.00	-0.378	1.230	-2.79	2.040
2.3	0.0796	200.00	-0.378	1.260	-2.84	2.080
2.4	0.0796	251.00	-0.378	1.260	-2.84	2.080

IgG3 V1V2 C.1086-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.1	0.0174	0.06590	0.134
0.1	0.7520	1.26	0.1	0.0205	0.05990	0.140
0.2	0.7200	1.58	0.1	0.0211	0.05870	0.141
0.3	0.6780	2.00	0.1	0.0217	0.05760	0.143
0.4	0.6480	2.51	0.1	0.0230	0.05500	0.145
0.5	0.6480	3.16	0.1	0.0230	0.05500	0.145
0.6	0.6140	3.98	0.1	0.0247	0.05170	0.148
0.7	0.5680	5.01	0.1	0.0260	0.04920	0.151
0.8	0.5020	6.31	0.1	0.0282	0.04470	0.155
0.9	0.4600	7.94	0.1	0.0340	0.03340	0.167
1.0	0.4210	10.00	0.1	0.0272	0.04680	0.153
1.1	0.3980	12.60	0.1	0.0297	0.04180	0.158
1.2	0.3790	15.80	0.1	0.0311	0.03910	0.161
1.3	0.3310	20.00	0.1	0.0371	0.02730	0.173
1.4	0.2890	25.10	0.1	0.0383	0.02490	0.175
1.5	0.2730	31.60	0.1	0.0419	0.01790	0.182
1.6	0.2620	39.80	0.1	0.0446	0.01260	0.188
1.7	0.2430	50.10	0.1	0.0471	0.00773	0.192
1.8	0.1850	63.10	0.1	0.0460	0.00998	0.190
1.9	0.1630	79.40	0.1	0.0500	0.00201	0.198
2.0	0.1630	100.00	0.1	0.0500	0.00201	0.198
2.1	0.1360	126.00	0.1	0.0549	-0.00749	0.208
2.2	0.1360	158.00	0.1	0.0549	-0.00749	0.208
2.3	0.1210	200.00	0.1	0.0551	-0.00796	0.208
2.4	0.0843	251.00	0.1	0.0940	-0.08430	0.284
2.5	0.0843	316.00	0.1	0.0940	-0.08430	0.284
2.6	0.0765	398.00	0.1	0.0951	-0.08640	0.287

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.0913	0.0174	0.05600	0.130
0.1	1.26	0.7520	0.0841	0.0205	0.04390	0.124
0.2	1.58	0.7200	0.0862	0.0211	0.04490	0.128
0.3	2.00	0.6780	0.0844	0.0217	0.04200	0.127
0.4	2.51	0.6480	0.0898	0.0230	0.04470	0.135
0.5	3.16	0.6480	0.0898	0.0230	0.04470	0.135
0.6	3.98	0.6140	0.0979	0.0247	0.04950	0.146
0.7	5.01	0.5680	0.0981	0.0260	0.04720	0.149
0.8	6.31	0.5020	0.0984	0.0282	0.04300	0.154
0.9	7.94	0.4600	0.1160	0.0340	0.04950	0.183
1.0	10.00	0.4210	0.0855	0.0272	0.03230	0.139
1.1	12.60	0.3980	0.0902	0.0297	0.03200	0.149
1.2	15.80	0.3790	0.0977	0.0311	0.03680	0.159
1.3	20.00	0.3310	0.1220	0.0371	0.04890	0.194
1.4	25.10	0.2890	0.1190	0.0383	0.04390	0.194
1.5	31.60	0.2730	0.1240	0.0419	0.04140	0.206
1.6	39.80	0.2620	0.1310	0.0446	0.04360	0.219
1.7	50.10	0.2430	0.1430	0.0471	0.05080	0.235
1.8	63.10	0.1850	0.1090	0.0460	0.01900	0.199
1.9	79.40	0.1630	0.1050	0.0500	0.00646	0.203
2.0	100.00	0.1630	0.1050	0.0500	0.00646	0.203
2.1	126.00	0.1360	0.1660	0.0549	0.05810	0.273
2.2	158.00	0.1360	0.1660	0.0549	0.05810	0.273
2.3	200.00	0.1210	0.1630	0.0551	0.05530	0.271
2.4	251.00	0.0843	0.2040	0.0940	0.01940	0.388
2.5	316.00	0.0843	0.2040	0.0940	0.01940	0.388
2.6	398.00	0.0765	0.2190	0.0951	0.03280	0.406

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	-0.446	0.409	-1.25	0.355
0.1	0.7520	1.26	-0.446	0.437	-1.30	0.411
0.2	0.7200	1.58	-0.446	0.443	-1.31	0.423
0.3	0.6780	2.00	-0.446	0.449	-1.33	0.434
0.4	0.6480	2.51	-0.446	0.463	-1.35	0.461
0.5	0.6480	3.16	-0.446	0.463	-1.35	0.461
0.6	0.6140	3.98	-0.446	0.480	-1.39	0.495
0.7	0.5680	5.01	-0.446	0.494	-1.41	0.523
0.8	0.5020	6.31	-0.446	0.519	-1.46	0.572
0.9	0.4600	7.94	-0.446	0.587	-1.60	0.705
1.0	0.4210	10.00	-0.446	0.507	-1.44	0.549
1.1	0.3980	12.60	-0.446	0.537	-1.50	0.606
1.2	0.3790	15.80	-0.446	0.552	-1.53	0.637
1.3	0.3310	20.00	-0.446	0.625	-1.67	0.779
1.4	0.2890	25.10	-0.446	0.640	-1.70	0.809
1.5	0.2730	31.60	-0.446	0.685	-1.79	0.898
1.6	0.2620	39.80	-0.446	0.721	-1.86	0.967
1.7	0.2430	50.10	-0.446	0.753	-1.92	1.030
1.8	0.1850	63.10	-0.446	0.738	-1.89	1.000
1.9	0.1630	79.40	-0.446	0.791	-2.00	1.100
2.0	0.1630	100.00	-0.446	0.791	-2.00	1.100
2.1	0.1360	126.00	-0.446	0.856	-2.12	1.230
2.2	0.1360	158.00	-0.446	0.856	-2.12	1.230
2.3	0.1210	200.00	-0.446	0.859	-2.13	1.240
2.4	0.0843	251.00	-0.446	1.400	-3.18	2.290
2.5	0.0843	316.00	-0.446	1.400	-3.18	2.290
2.6	0.0765	398.00	-0.446	1.410	-3.21	2.320

IgG3 V1V2 C.1086-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.0913	0.0174	0.05710	0.125
0.1	0.740	1.26	0.0848	0.0213	0.04310	0.127
0.2	0.732	1.58	0.0848	0.0216	0.04250	0.127
0.3	0.722	2.00	0.0829	0.0215	0.04090	0.125
0.4	0.666	2.51	0.0829	0.0224	0.03900	0.127
0.5	0.666	3.16	0.0829	0.0224	0.03900	0.127
0.6	0.628	3.98	0.0829	0.0231	0.03770	0.128
0.7	0.571	5.01	0.0712	0.0213	0.02940	0.113
0.8	0.528	6.31	0.0712	0.0225	0.02710	0.115
0.9	0.472	7.94	0.0712	0.0251	0.02200	0.120
1.0	0.387	10.00	0.0712	0.0276	0.01710	0.125
1.1	0.347	12.60	0.0712	0.0285	0.01530	0.127
1.2	0.319	15.80	0.0712	0.0320	0.00858	0.134
1.3	0.259	20.00	0.0712	0.0352	0.00223	0.140
1.4	0.241	25.10	0.0712	0.0389	-0.00494	0.147
1.5	0.195	31.60	0.0712	0.0605	-0.04730	0.190
1.6	0.156	39.80	0.0712	0.0402	-0.00761	0.150
1.7	0.147	50.10	0.0712	0.0406	-0.00833	0.151
1.8	0.132	63.10	0.0712	0.0493	-0.02540	0.168
1.9	0.128	79.40	0.0712	0.0469	-0.02060	0.163

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.0913	0.0174	0.05740	0.133
0.1	1.26	0.740	0.0844	0.0213	0.04260	0.126
0.2	1.58	0.732	0.0853	0.0216	0.04300	0.128
0.3	2.00	0.722	0.0821	0.0215	0.04000	0.124
0.4	2.51	0.666	0.0822	0.0224	0.03820	0.126
0.5	3.16	0.666	0.0822	0.0224	0.03820	0.126
0.6	3.98	0.628	0.0853	0.0231	0.04000	0.131
0.7	5.01	0.571	0.0662	0.0213	0.02440	0.108
0.8	6.31	0.528	0.0703	0.0225	0.02610	0.114
0.9	7.94	0.472	0.0774	0.0251	0.02820	0.127
1.0	10.00	0.387	0.0831	0.0276	0.02890	0.137
1.1	12.60	0.347	0.0801	0.0285	0.02410	0.136
1.2	15.80	0.319	0.0896	0.0320	0.02690	0.152
1.3	20.00	0.259	0.0916	0.0352	0.02260	0.161
1.4	25.10	0.241	0.1040	0.0389	0.02740	0.180
1.5	31.60	0.195	0.1450	0.0605	0.02600	0.263
1.6	39.80	0.156	0.0897	0.0402	0.01090	0.169
1.7	50.10	0.147	0.0851	0.0406	0.00557	0.165
1.8	63.10	0.132	0.1010	0.0493	0.00406	0.197
1.9	79.40	0.128	0.0871	0.0469	-0.00473	0.179

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	-0.3190	0.387	-1.080	0.439
0.1	0.740	1.26	-0.2260	0.411	-1.030	0.580
0.2	0.732	1.58	-0.2260	0.414	-1.040	0.586
0.3	0.722	2.00	-0.1990	0.409	-1.000	0.603
0.4	0.666	2.51	-0.1990	0.420	-1.020	0.624
0.5	0.666	3.16	-0.1990	0.420	-1.020	0.624
0.6	0.628	3.98	-0.1990	0.427	-1.040	0.639
0.7	0.571	5.01	-0.0295	0.384	-0.782	0.723
0.8	0.528	6.31	-0.0295	0.398	-0.810	0.751
0.9	0.472	7.94	-0.0295	0.429	-0.870	0.811
1.0	0.387	10.00	-0.0295	0.460	-0.932	0.873
1.1	0.347	12.60	-0.0295	0.472	-0.954	0.895
1.2	0.319	15.80	-0.0295	0.516	-1.040	0.981
1.3	0.259	20.00	-0.0295	0.558	-1.120	1.060
1.4	0.241	25.10	-0.0295	0.607	-1.220	1.160
1.5	0.195	31.60	-0.0295	0.903	-1.800	1.740
1.6	0.156	39.80	-0.0295	0.625	-1.250	1.200
1.7	0.147	50.10	-0.0295	0.630	-1.260	1.200
1.8	0.132	63.10	-0.0295	0.748	-1.500	1.440
1.9	0.128	79.40	-0.0295	0.715	-1.430	1.370

RV144 (24 month)

• Adjustment covariates: dem_sex, BRA_risk
• Event time variable: HIVwk26fu
• Event type variable: HIVwk26
• Weight variable: sample_weight
• Reference timepoint: 459 days
• All learners: GLM

IgG V1V2 B.CaseA-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00361	0.000724	0.002190	0.00503
0.1	0.995	1.26	0.00349	0.000758	0.002000	0.00497
0.2	0.995	1.58	0.00349	0.000758	0.002000	0.00497
0.3	0.995	2.00	0.00349	0.000758	0.002000	0.00497
0.4	0.994	2.51	0.00349	0.000758	0.002000	0.00497
0.5	0.994	3.16	0.00349	0.000758	0.002000	0.00497
0.6	0.994	3.98	0.00349	0.000758	0.002000	0.00497
0.7	0.994	5.01	0.00349	0.000758	0.002000	0.00497
0.8	0.992	6.31	0.00349	0.000759	0.002000	0.00498
0.9	0.992	7.94	0.00349	0.000759	0.002000	0.00498
1.0	0.989	10.00	0.00349	0.000760	0.002000	0.00498
1.1	0.988	12.60	0.00349	0.000761	0.002000	0.00498
1.2	0.982	15.80	0.00349	0.000766	0.001990	0.00499
1.3	0.974	20.00	0.00349	0.000770	0.001980	0.00500
1.4	0.972	25.10	0.00341	0.000754	0.001940	0.00489
1.5	0.967	31.60	0.00341	0.000757	0.001930	0.00490
1.6	0.959	39.80	0.00341	0.000763	0.001920	0.00491
1.7	0.955	50.10	0.00331	0.000748	0.001840	0.00477
1.8	0.934	63.10	0.00322	0.000747	0.001760	0.00469
1.9	0.933	79.40	0.00309	0.000729	0.001670	0.00452
2.0	0.920	100.00	0.00309	0.000737	0.001650	0.00454
2.1	0.907	126.00	0.00299	0.000726	0.001570	0.00442
2.2	0.882	158.00	0.00291	0.000724	0.001490	0.00433
2.3	0.828	200.00	0.00271	0.000716	0.001310	0.00411
2.4	0.790	251.00	0.00271	0.000733	0.001270	0.00415
2.5	0.731	316.00	0.00271	0.000771	0.001200	0.00422
2.6	0.674	398.00	0.00233	0.000741	0.000882	0.00379
2.7	0.617	501.00	0.00229	0.000764	0.000790	0.00379
2.8	0.522	631.00	0.00229	0.000842	0.000637	0.00394
2.9	0.487	794.00	0.00229	0.000918	0.000488	0.00409
3.0	0.411	1000.00	0.00229	0.001110	0.000116	0.00446
3.1	0.351	1260.00	0.00229	0.001250	-0.000163	0.00474
3.2	0.280	1580.00	0.00229	0.001440	-0.000532	0.00511
3.3	0.206	2000.00	0.00229	0.001740	-0.001130	0.00570
3.4	0.165	2510.00	0.00229	0.001450	-0.000557	0.00513

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	0.002100	0.00513
0.1	1.26	0.995	0.00348	0.000758	0.001990	0.00496
0.2	1.58	0.995	0.00348	0.000758	0.001990	0.00496
0.3	2.00	0.995	0.00348	0.000758	0.001990	0.00496
0.4	2.51	0.994	0.00348	0.000758	0.001990	0.00497
0.5	3.16	0.994	0.00348	0.000758	0.001990	0.00497
0.6	3.98	0.994	0.00348	0.000758	0.001990	0.00497
0.7	5.01	0.994	0.00348	0.000758	0.001990	0.00497
0.8	6.31	0.992	0.00348	0.000759	0.001990	0.00497
0.9	7.94	0.992	0.00348	0.000759	0.001990	0.00497
1.0	10.00	0.989	0.00349	0.000760	0.002000	0.00498
1.1	12.60	0.988	0.00349	0.000761	0.002000	0.00498
1.2	15.80	0.982	0.00351	0.000766	0.002010	0.00501
1.3	20.00	0.974	0.00354	0.000770	0.002030	0.00505
1.4	25.10	0.972	0.00340	0.000754	0.001920	0.00487
1.5	31.60	0.967	0.00341	0.000757	0.001920	0.00489
1.6	39.80	0.959	0.00344	0.000763	0.001940	0.00494
1.7	50.10	0.955	0.00331	0.000748	0.001840	0.00477
1.8	63.10	0.934	0.00322	0.000747	0.001760	0.00469
1.9	79.40	0.933	0.00308	0.000729	0.001650	0.00451
2.0	100.00	0.920	0.00311	0.000737	0.001670	0.00455
2.1	126.00	0.907	0.00299	0.000726	0.001570	0.00442
2.2	158.00	0.882	0.00291	0.000724	0.001490	0.00433
2.3	200.00	0.828	0.00271	0.000716	0.001310	0.00411
2.4	251.00	0.790	0.00269	0.000733	0.001250	0.00413
2.5	316.00	0.731	0.00273	0.000771	0.001220	0.00424
2.6	398.00	0.674	0.00233	0.000741	0.000882	0.00379
2.7	501.00	0.617	0.00228	0.000764	0.000787	0.00378
2.8	631.00	0.522	0.00239	0.000842	0.000738	0.00404
2.9	794.00	0.487	0.00260	0.000918	0.000804	0.00440
3.0	1000.00	0.411	0.00290	0.001110	0.000729	0.00507
3.1	1260.00	0.351	0.00322	0.001250	0.000774	0.00567
3.2	1580.00	0.280	0.00321	0.001440	0.000391	0.00603
3.3	2000.00	0.206	0.00301	0.001740	-0.000402	0.00643
3.4	2510.00	0.165	0.00239	0.001450	-0.000459	0.00523

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.220	0.214	-0.19900	0.638
0.1	0.995	1.26	0.246	0.216	-0.17600	0.669
0.2	0.995	1.58	0.246	0.216	-0.17600	0.669
0.3	0.995	2.00	0.246	0.216	-0.17600	0.669
0.4	0.994	2.51	0.246	0.216	-0.17700	0.669
0.5	0.994	3.16	0.246	0.216	-0.17700	0.669
0.6	0.994	3.98	0.246	0.216	-0.17700	0.669
0.7	0.994	5.01	0.246	0.216	-0.17700	0.669
0.8	0.992	6.31	0.246	0.216	-0.17700	0.669
0.9	0.992	7.94	0.246	0.216	-0.17700	0.669
1.0	0.989	10.00	0.246	0.216	-0.17700	0.670
1.1	0.988	12.60	0.246	0.216	-0.17800	0.670
1.2	0.982	15.80	0.246	0.217	-0.17900	0.672
1.3	0.974	20.00	0.246	0.218	-0.18100	0.673
1.4	0.972	25.10	0.262	0.213	-0.15600	0.680
1.5	0.967	31.60	0.262	0.214	-0.15700	0.681
1.6	0.959	39.80	0.262	0.215	-0.15900	0.683
1.7	0.955	50.10	0.286	0.209	-0.12500	0.696
1.8	0.934	63.10	0.303	0.207	-0.10300	0.709
1.9	0.933	79.40	0.331	0.201	-0.06200	0.725
2.0	0.920	100.00	0.331	0.202	-0.06470	0.728
2.1	0.907	126.00	0.353	0.198	-0.03440	0.741
2.2	0.882	158.00	0.372	0.195	-0.01120	0.755
2.3	0.828	200.00	0.415	0.189	0.04370	0.785
2.4	0.790	251.00	0.415	0.192	0.03770	0.791
2.5	0.731	316.00	0.415	0.199	0.02440	0.805
2.6	0.674	398.00	0.496	0.186	0.13200	0.859
2.7	0.617	501.00	0.506	0.189	0.13500	0.876
2.8	0.522	631.00	0.506	0.204	0.10600	0.905
2.9	0.487	794.00	0.506	0.219	0.07680	0.934
3.0	0.411	1000.00	0.506	0.257	0.00264	1.010
3.1	0.351	1260.00	0.506	0.285	-0.05390	1.070
3.2	0.280	1580.00	0.506	0.324	-0.13000	1.140
3.3	0.206	2000.00	0.506	0.388	-0.25400	1.270
3.4	0.165	2510.00	0.506	0.327	-0.13500	1.150

IgG V1V2 AE.A244-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00362	0.000724	0.002200	0.00504
0.1	0.995	1.26	0.00362	0.000775	0.002100	0.00514
0.2	0.995	1.58	0.00362	0.000775	0.002100	0.00514
0.3	0.995	2.00	0.00362	0.000775	0.002100	0.00514
0.4	0.995	2.51	0.00362	0.000775	0.002100	0.00514
0.5	0.995	3.16	0.00362	0.000775	0.002100	0.00514
0.6	0.995	3.98	0.00362	0.000775	0.002100	0.00514
0.7	0.994	5.01	0.00362	0.000776	0.002100	0.00514
0.8	0.992	6.31	0.00362	0.000776	0.002100	0.00514
0.9	0.992	7.94	0.00349	0.000759	0.002000	0.00498
1.0	0.992	10.00	0.00349	0.000759	0.002000	0.00498
1.1	0.992	12.60	0.00349	0.000759	0.002000	0.00498
1.2	0.992	15.80	0.00349	0.000759	0.002000	0.00498
1.3	0.992	20.00	0.00349	0.000759	0.002000	0.00498
1.4	0.992	25.10	0.00349	0.000759	0.002000	0.00498
1.5	0.992	31.60	0.00349	0.000759	0.002000	0.00498
1.6	0.992	39.80	0.00349	0.000759	0.002000	0.00498
1.7	0.992	50.10	0.00349	0.000759	0.002000	0.00498
1.8	0.991	63.10	0.00349	0.000760	0.002000	0.00498
1.9	0.991	79.40	0.00349	0.000760	0.002000	0.00498
2.0	0.991	100.00	0.00349	0.000760	0.002000	0.00498
2.1	0.989	126.00	0.00349	0.000760	0.002000	0.00498
2.2	0.988	158.00	0.00349	0.000761	0.002000	0.00498
2.3	0.988	200.00	0.00349	0.000761	0.002000	0.00498
2.4	0.988	251.00	0.00349	0.000761	0.002000	0.00498
2.5	0.986	316.00	0.00349	0.000763	0.001990	0.00498
2.6	0.986	398.00	0.00349	0.000763	0.001990	0.00498
2.7	0.981	501.00	0.00349	0.000765	0.001990	0.00499
2.8	0.981	631.00	0.00337	0.000748	0.001900	0.00483
2.9	0.981	794.00	0.00337	0.000748	0.001900	0.00483
3.0	0.981	1000.00	0.00337	0.000748	0.001900	0.00483
3.1	0.979	1260.00	0.00328	0.000731	0.001850	0.00472
3.2	0.967	1580.00	0.00328	0.000743	0.001830	0.00474
3.3	0.958	2000.00	0.00328	0.000749	0.001810	0.00475
3.4	0.957	2510.00	0.00328	0.000751	0.001810	0.00475
3.5	0.944	3160.00	0.00319	0.000739	0.001750	0.00464
3.6	0.924	3980.00	0.00310	0.000734	0.001660	0.00453
3.7	0.898	5010.00	0.00285	0.000710	0.001460	0.00424
3.8	0.855	6310.00	0.00270	0.000709	0.001310	0.00409
3.9	0.805	7940.00	0.00262	0.000702	0.001240	0.00399
4.0	0.733	10000.00	0.00262	0.000759	0.001130	0.00411
4.1	0.623	12600.00	0.00262	0.000849	0.000956	0.00428
4.2	0.573	15800.00	0.00249	0.000830	0.000862	0.00412
4.3	0.477	20000.00	0.00249	0.000924	0.000679	0.00430
4.4	0.236	25100.00	0.00249	0.001640	-0.000729	0.00571

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	0.002100	0.00513
0.1	1.26	0.995	0.00362	0.000775	0.002100	0.00514
0.2	1.58	0.995	0.00362	0.000775	0.002100	0.00514
0.3	2.00	0.995	0.00362	0.000775	0.002100	0.00514
0.4	2.51	0.995	0.00362	0.000775	0.002100	0.00514
0.5	3.16	0.995	0.00362	0.000775	0.002100	0.00514
0.6	3.98	0.995	0.00362	0.000775	0.002100	0.00514
0.7	5.01	0.994	0.00362	0.000776	0.002100	0.00514
0.8	6.31	0.992	0.00363	0.000776	0.002110	0.00515
0.9	7.94	0.992	0.00348	0.000759	0.001990	0.00497
1.0	10.00	0.992	0.00348	0.000759	0.001990	0.00497
1.1	12.60	0.992	0.00348	0.000759	0.001990	0.00497
1.2	15.80	0.992	0.00348	0.000759	0.001990	0.00497
1.3	20.00	0.992	0.00348	0.000759	0.001990	0.00497
1.4	25.10	0.992	0.00348	0.000759	0.001990	0.00497
1.5	31.60	0.992	0.00348	0.000759	0.001990	0.00497
1.6	39.80	0.992	0.00348	0.000759	0.001990	0.00497
1.7	50.10	0.992	0.00348	0.000759	0.001990	0.00497
1.8	63.10	0.991	0.00348	0.000760	0.002000	0.00497
1.9	79.40	0.991	0.00348	0.000760	0.002000	0.00497
2.0	100.00	0.991	0.00348	0.000760	0.002000	0.00497
2.1	126.00	0.989	0.00349	0.000760	0.002000	0.00498
2.2	158.00	0.988	0.00349	0.000761	0.002000	0.00498
2.3	200.00	0.988	0.00349	0.000761	0.002000	0.00498
2.4	251.00	0.988	0.00349	0.000761	0.002000	0.00498
2.5	316.00	0.986	0.00350	0.000763	0.002010	0.00500
2.6	398.00	0.986	0.00350	0.000763	0.002010	0.00500
2.7	501.00	0.981	0.00351	0.000765	0.002010	0.00501
2.8	631.00	0.981	0.00337	0.000748	0.001900	0.00483
2.9	794.00	0.981	0.00337	0.000748	0.001900	0.00483
3.0	1000.00	0.981	0.00337	0.000748	0.001900	0.00483
3.1	1260.00	0.979	0.00323	0.000731	0.001790	0.00466
3.2	1580.00	0.967	0.00328	0.000743	0.001830	0.00474
3.3	2000.00	0.958	0.00331	0.000749	0.001840	0.00478
3.4	2510.00	0.957	0.00331	0.000751	0.001840	0.00479
3.5	3160.00	0.944	0.00319	0.000739	0.001750	0.00464
3.6	3980.00	0.924	0.00310	0.000734	0.001660	0.00453
3.7	5010.00	0.898	0.00285	0.000710	0.001460	0.00424
3.8	6310.00	0.855	0.00270	0.000709	0.001310	0.00409
3.9	7940.00	0.805	0.00250	0.000702	0.001130	0.00388
4.0	10000.00	0.733	0.00260	0.000759	0.001110	0.00409
4.1	12600.00	0.623	0.00278	0.000849	0.001110	0.00444
4.2	15800.00	0.573	0.00249	0.000830	0.000862	0.00412
4.3	20000.00	0.477	0.00245	0.000924	0.000639	0.00426
4.4	25100.00	0.236	0.00306	0.001640	-0.000157	0.00628

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.217	0.214	-0.20200	0.637
0.1	0.995	1.26	0.217	0.222	-0.21800	0.652
0.2	0.995	1.58	0.217	0.222	-0.21800	0.652
0.3	0.995	2.00	0.217	0.222	-0.21800	0.652
0.4	0.995	2.51	0.217	0.222	-0.21800	0.652
0.5	0.995	3.16	0.217	0.222	-0.21800	0.652
0.6	0.995	3.98	0.217	0.222	-0.21800	0.652
0.7	0.994	5.01	0.217	0.222	-0.21800	0.653
0.8	0.992	6.31	0.217	0.222	-0.21800	0.653
0.9	0.992	7.94	0.246	0.216	-0.17700	0.669
1.0	0.992	10.00	0.246	0.216	-0.17700	0.669
1.1	0.992	12.60	0.246	0.216	-0.17700	0.669
1.2	0.992	15.80	0.246	0.216	-0.17700	0.669
1.3	0.992	20.00	0.246	0.216	-0.17700	0.669
1.4	0.992	25.10	0.246	0.216	-0.17700	0.669
1.5	0.992	31.60	0.246	0.216	-0.17700	0.669
1.6	0.992	39.80	0.246	0.216	-0.17700	0.669
1.7	0.992	50.10	0.246	0.216	-0.17700	0.669
1.8	0.991	63.10	0.246	0.216	-0.17700	0.670
1.9	0.991	79.40	0.246	0.216	-0.17700	0.670
2.0	0.991	100.00	0.246	0.216	-0.17700	0.670
2.1	0.989	126.00	0.246	0.216	-0.17700	0.670
2.2	0.988	158.00	0.246	0.216	-0.17800	0.670
2.3	0.988	200.00	0.246	0.216	-0.17800	0.670
2.4	0.988	251.00	0.246	0.216	-0.17800	0.670
2.5	0.986	316.00	0.246	0.217	-0.17800	0.671
2.6	0.986	398.00	0.246	0.217	-0.17800	0.671
2.7	0.981	501.00	0.246	0.217	-0.17900	0.671
2.8	0.981	631.00	0.272	0.211	-0.14100	0.686
2.9	0.981	794.00	0.272	0.211	-0.14100	0.686
3.0	0.981	1000.00	0.272	0.211	-0.14100	0.686
3.1	0.979	1260.00	0.291	0.206	-0.11300	0.694
3.2	0.967	1580.00	0.291	0.208	-0.11700	0.698
3.3	0.958	2000.00	0.291	0.209	-0.11900	0.700
3.4	0.957	2510.00	0.291	0.209	-0.12000	0.701
3.5	0.944	3160.00	0.310	0.205	-0.09230	0.712
3.6	0.924	3980.00	0.331	0.202	-0.06450	0.726
3.7	0.898	5010.00	0.383	0.192	0.00777	0.759
3.8	0.855	6310.00	0.417	0.188	0.04930	0.786
3.9	0.805	7940.00	0.434	0.185	0.07200	0.796
4.0	0.733	10000.00	0.434	0.195	0.05180	0.816
4.1	0.623	12600.00	0.434	0.212	0.01920	0.849
4.2	0.573	15800.00	0.462	0.206	0.05920	0.865
4.3	0.477	20000.00	0.462	0.223	0.02430	0.900
4.4	0.236	25100.00	0.462	0.369	-0.26100	1.180

IgG V1V2 C.1086-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00361	0.000724	0.002190	0.00503
0.1	0.995	1.26	0.00349	0.000758	0.002000	0.00497
0.2	0.994	1.58	0.00349	0.000758	0.002000	0.00497
0.3	0.994	2.00	0.00349	0.000758	0.002000	0.00497
0.4	0.992	2.51	0.00349	0.000759	0.002000	0.00498
0.5	0.992	3.16	0.00349	0.000759	0.002000	0.00498
0.6	0.992	3.98	0.00349	0.000759	0.002000	0.00498
0.7	0.992	5.01	0.00349	0.000759	0.002000	0.00498
0.8	0.992	6.31	0.00349	0.000759	0.002000	0.00498
0.9	0.992	7.94	0.00349	0.000759	0.002000	0.00498
1.0	0.992	10.00	0.00349	0.000759	0.002000	0.00498
1.1	0.992	12.60	0.00349	0.000759	0.002000	0.00498
1.2	0.992	15.80	0.00349	0.000759	0.002000	0.00498
1.3	0.991	20.00	0.00349	0.000760	0.002000	0.00498
1.4	0.991	25.10	0.00349	0.000760	0.002000	0.00498
1.5	0.989	31.60	0.00349	0.000761	0.002000	0.00498
1.6	0.988	39.80	0.00349	0.000762	0.002000	0.00498
1.7	0.988	50.10	0.00349	0.000762	0.002000	0.00498
1.8	0.988	63.10	0.00349	0.000762	0.002000	0.00498
1.9	0.981	79.40	0.00349	0.000765	0.001990	0.00499
2.0	0.981	100.00	0.00349	0.000765	0.001990	0.00499
2.1	0.981	126.00	0.00349	0.000765	0.001990	0.00499
2.2	0.981	158.00	0.00337	0.000748	0.001900	0.00483
2.3	0.981	200.00	0.00337	0.000748	0.001900	0.00483
2.4	0.981	251.00	0.00337	0.000748	0.001900	0.00483
2.5	0.963	316.00	0.00332	0.000747	0.001860	0.00478
2.6	0.953	398.00	0.00332	0.000753	0.001840	0.00480
2.7	0.949	501.00	0.00332	0.000756	0.001840	0.00480
2.8	0.944	631.00	0.00319	0.000738	0.001740	0.00464
2.9	0.940	794.00	0.00308	0.000720	0.001670	0.00449
3.0	0.931	1000.00	0.00308	0.000725	0.001660	0.00450
3.1	0.902	1260.00	0.00308	0.000744	0.001620	0.00454
3.2	0.849	1580.00	0.00285	0.000730	0.001420	0.00428
3.3	0.795	2000.00	0.00274	0.000744	0.001280	0.00420
3.4	0.741	2510.00	0.00255	0.000745	0.001090	0.00401
3.5	0.637	3160.00	0.00230	0.000762	0.000802	0.00379
3.6	0.558	3980.00	0.00230	0.000807	0.000713	0.00388
3.7	0.471	5010.00	0.00230	0.000876	0.000579	0.00401
3.8	0.393	6310.00	0.00230	0.001100	0.000137	0.00445
3.9	0.285	7940.00	0.00230	0.001340	-0.000325	0.00492
4.0	0.200	10000.00	0.00230	0.001720	-0.001080	0.00567
4.1	0.159	12600.00	0.00230	0.002130	-0.001870	0.00646

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	0.002100	0.00513
0.1	1.26	0.995	0.00348	0.000758	0.001990	0.00496
0.2	1.58	0.994	0.00348	0.000758	0.001990	0.00497
0.3	2.00	0.994	0.00348	0.000758	0.001990	0.00497
0.4	2.51	0.992	0.00348	0.000759	0.001990	0.00497
0.5	3.16	0.992	0.00348	0.000759	0.001990	0.00497
0.6	3.98	0.992	0.00348	0.000759	0.001990	0.00497
0.7	5.01	0.992	0.00348	0.000759	0.001990	0.00497
0.8	6.31	0.992	0.00348	0.000759	0.001990	0.00497
0.9	7.94	0.992	0.00348	0.000759	0.001990	0.00497
1.0	10.00	0.992	0.00348	0.000759	0.001990	0.00497
1.1	12.60	0.992	0.00348	0.000759	0.001990	0.00497
1.2	15.80	0.992	0.00348	0.000759	0.001990	0.00497
1.3	20.00	0.991	0.00348	0.000760	0.002000	0.00497
1.4	25.10	0.991	0.00348	0.000760	0.002000	0.00497
1.5	31.60	0.989	0.00349	0.000761	0.002000	0.00499
1.6	39.80	0.988	0.00350	0.000762	0.002000	0.00499
1.7	50.10	0.988	0.00350	0.000762	0.002000	0.00499
1.8	63.10	0.988	0.00350	0.000762	0.002000	0.00499
1.9	79.40	0.981	0.00351	0.000765	0.002010	0.00501
2.0	100.00	0.981	0.00351	0.000765	0.002010	0.00501
2.1	126.00	0.981	0.00351	0.000765	0.002010	0.00501
2.2	158.00	0.981	0.00337	0.000748	0.001900	0.00483
2.3	200.00	0.981	0.00337	0.000748	0.001900	0.00483
2.4	251.00	0.981	0.00337	0.000748	0.001900	0.00483
2.5	316.00	0.963	0.00330	0.000747	0.001840	0.00477
2.6	398.00	0.953	0.00332	0.000753	0.001850	0.00480
2.7	501.00	0.949	0.00334	0.000756	0.001850	0.00482
2.8	631.00	0.944	0.00319	0.000738	0.001740	0.00464
2.9	794.00	0.940	0.00304	0.000720	0.001630	0.00446
3.0	1000.00	0.931	0.00306	0.000725	0.001640	0.00448
3.1	1260.00	0.902	0.00314	0.000744	0.001680	0.00460
3.2	1580.00	0.849	0.00285	0.000730	0.001420	0.00428
3.3	2000.00	0.795	0.00274	0.000744	0.001280	0.00420
3.4	2510.00	0.741	0.00255	0.000745	0.001090	0.00401
3.5	3160.00	0.637	0.00229	0.000762	0.000800	0.00379
3.6	3980.00	0.558	0.00230	0.000807	0.000715	0.00388
3.7	5010.00	0.471	0.00220	0.000876	0.000479	0.00391
3.8	6310.00	0.393	0.00268	0.001100	0.000520	0.00484
3.9	7940.00	0.285	0.00274	0.001340	0.000122	0.00536
4.0	10000.00	0.200	0.00310	0.001720	-0.000272	0.00648
4.1	12600.00	0.159	0.00377	0.002130	-0.000400	0.00794

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.220	0.214	-0.19900	0.638
0.1	0.995	1.26	0.246	0.216	-0.17700	0.669
0.2	0.994	1.58	0.246	0.216	-0.17700	0.669
0.3	0.994	2.00	0.246	0.216	-0.17700	0.669
0.4	0.992	2.51	0.246	0.216	-0.17700	0.669
0.5	0.992	3.16	0.246	0.216	-0.17700	0.669
0.6	0.992	3.98	0.246	0.216	-0.17700	0.669
0.7	0.992	5.01	0.246	0.216	-0.17700	0.669
0.8	0.992	6.31	0.246	0.216	-0.17700	0.669
0.9	0.992	7.94	0.246	0.216	-0.17700	0.669
1.0	0.992	10.00	0.246	0.216	-0.17700	0.669
1.1	0.992	12.60	0.246	0.216	-0.17700	0.669
1.2	0.992	15.80	0.246	0.216	-0.17700	0.669
1.3	0.991	20.00	0.246	0.216	-0.17700	0.669
1.4	0.991	25.10	0.246	0.216	-0.17700	0.669
1.5	0.989	31.60	0.246	0.216	-0.17800	0.670
1.6	0.988	39.80	0.246	0.216	-0.17800	0.670
1.7	0.988	50.10	0.246	0.216	-0.17800	0.670
1.8	0.988	63.10	0.246	0.216	-0.17800	0.670
1.9	0.981	79.40	0.246	0.217	-0.17900	0.671
2.0	0.981	100.00	0.246	0.217	-0.17900	0.671
2.1	0.981	126.00	0.246	0.217	-0.17900	0.671
2.2	0.981	158.00	0.272	0.211	-0.14100	0.686
2.3	0.981	200.00	0.272	0.211	-0.14100	0.686
2.4	0.981	251.00	0.272	0.211	-0.14100	0.686
2.5	0.963	316.00	0.283	0.210	-0.12800	0.693
2.6	0.953	398.00	0.283	0.210	-0.13000	0.695
2.7	0.949	501.00	0.283	0.211	-0.13100	0.696
2.8	0.944	631.00	0.311	0.205	-0.09040	0.712
2.9	0.940	794.00	0.334	0.199	-0.05600	0.724
3.0	0.931	1000.00	0.334	0.200	-0.05740	0.726
3.1	0.902	1260.00	0.334	0.203	-0.06400	0.732
3.2	0.849	1580.00	0.384	0.195	0.00198	0.766
3.3	0.795	2000.00	0.409	0.195	0.02650	0.791
3.4	0.741	2510.00	0.449	0.191	0.07450	0.823
3.5	0.637	3160.00	0.504	0.189	0.13400	0.874
3.6	0.558	3980.00	0.504	0.197	0.11700	0.891
3.7	0.471	5010.00	0.504	0.211	0.09130	0.917
3.8	0.393	6310.00	0.504	0.255	0.00383	1.000
3.9	0.285	7940.00	0.504	0.303	-0.09040	1.100
4.0	0.200	10000.00	0.504	0.384	-0.24800	1.260
4.1	0.159	12600.00	0.504	0.469	-0.41500	1.420

IgG V1V2 C.1086-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00362	0.000724	0.002200	0.00504
0.1	0.995	1.26	0.00362	0.000775	0.002100	0.00514
0.2	0.995	1.58	0.00362	0.000775	0.002100	0.00514
0.3	0.995	2.00	0.00362	0.000775	0.002100	0.00514
0.4	0.994	2.51	0.00362	0.000776	0.002100	0.00514
0.5	0.992	3.16	0.00362	0.000776	0.002100	0.00514
0.6	0.992	3.98	0.00362	0.000776	0.002100	0.00514
0.7	0.992	5.01	0.00349	0.000759	0.002000	0.00498
0.8	0.992	6.31	0.00349	0.000759	0.002000	0.00498
0.9	0.992	7.94	0.00349	0.000759	0.002000	0.00498
1.0	0.992	10.00	0.00349	0.000759	0.002000	0.00498
1.1	0.991	12.60	0.00349	0.000760	0.002000	0.00498
1.2	0.991	15.80	0.00349	0.000760	0.002000	0.00498
1.3	0.991	20.00	0.00349	0.000760	0.002000	0.00498
1.4	0.991	25.10	0.00349	0.000760	0.002000	0.00498
1.5	0.991	31.60	0.00349	0.000760	0.002000	0.00498
1.6	0.991	39.80	0.00349	0.000760	0.002000	0.00498
1.7	0.991	50.10	0.00349	0.000760	0.002000	0.00498
1.8	0.991	63.10	0.00349	0.000760	0.002000	0.00498
1.9	0.989	79.40	0.00349	0.000761	0.002000	0.00498
2.0	0.988	100.00	0.00349	0.000762	0.002000	0.00499
2.1	0.986	126.00	0.00349	0.000763	0.002000	0.00499
2.2	0.986	158.00	0.00349	0.000763	0.002000	0.00499
2.3	0.986	200.00	0.00349	0.000763	0.002000	0.00499
2.4	0.986	251.00	0.00349	0.000763	0.002000	0.00499
2.5	0.981	316.00	0.00349	0.000765	0.001990	0.00499
2.6	0.981	398.00	0.00349	0.000765	0.001990	0.00499
2.7	0.981	501.00	0.00343	0.000748	0.001960	0.00489
2.8	0.977	631.00	0.00343	0.000753	0.001950	0.00490
2.9	0.960	794.00	0.00343	0.000766	0.001920	0.00493
3.0	0.960	1000.00	0.00343	0.000766	0.001920	0.00493
3.1	0.956	1260.00	0.00343	0.000769	0.001920	0.00493
3.2	0.946	1580.00	0.00334	0.000756	0.001860	0.00482
3.3	0.928	2000.00	0.00308	0.000728	0.001650	0.00450
3.4	0.909	2510.00	0.00306	0.000727	0.001630	0.00449
3.5	0.889	3160.00	0.00306	0.000744	0.001600	0.00452
3.6	0.855	3980.00	0.00306	0.000751	0.001590	0.00453
3.7	0.767	5010.00	0.00306	0.000808	0.001480	0.00464
3.8	0.685	6310.00	0.00306	0.000800	0.001490	0.00463
3.9	0.593	7940.00	0.00306	0.000919	0.001260	0.00486
4.0	0.498	10000.00	0.00306	0.001140	0.000834	0.00529
4.1	0.410	12600.00	0.00306	0.001120	0.000865	0.00526
4.2	0.326	15800.00	0.00306	0.001290	0.000540	0.00558
4.3	0.240	20000.00	0.00306	0.001650	-0.000170	0.00629

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	0.002100	0.00513
0.1	1.26	0.995	0.00362	0.000775	0.002100	0.00514
0.2	1.58	0.995	0.00362	0.000775	0.002100	0.00514
0.3	2.00	0.995	0.00362	0.000775	0.002100	0.00514
0.4	2.51	0.994	0.00362	0.000776	0.002100	0.00514
0.5	3.16	0.992	0.00363	0.000776	0.002110	0.00515
0.6	3.98	0.992	0.00363	0.000776	0.002110	0.00515
0.7	5.01	0.992	0.00348	0.000759	0.001990	0.00497
0.8	6.31	0.992	0.00348	0.000759	0.001990	0.00497
0.9	7.94	0.992	0.00348	0.000759	0.001990	0.00497
1.0	10.00	0.992	0.00348	0.000759	0.001990	0.00497
1.1	12.60	0.991	0.00348	0.000760	0.002000	0.00497
1.2	15.80	0.991	0.00348	0.000760	0.002000	0.00497
1.3	20.00	0.991	0.00348	0.000760	0.002000	0.00497
1.4	25.10	0.991	0.00348	0.000760	0.002000	0.00497
1.5	31.60	0.991	0.00348	0.000760	0.002000	0.00497
1.6	39.80	0.991	0.00348	0.000760	0.002000	0.00497
1.7	50.10	0.991	0.00348	0.000760	0.002000	0.00497
1.8	63.10	0.991	0.00348	0.000760	0.002000	0.00497
1.9	79.40	0.989	0.00349	0.000761	0.002000	0.00499
2.0	100.00	0.988	0.00350	0.000762	0.002010	0.00499
2.1	126.00	0.986	0.00350	0.000763	0.002010	0.00500
2.2	158.00	0.986	0.00350	0.000763	0.002010	0.00500
2.3	200.00	0.986	0.00350	0.000763	0.002010	0.00500
2.4	251.00	0.986	0.00350	0.000763	0.002010	0.00500
2.5	316.00	0.981	0.00351	0.000765	0.002010	0.00501
2.6	398.00	0.981	0.00351	0.000765	0.002010	0.00501
2.7	501.00	0.981	0.00337	0.000748	0.001900	0.00483
2.8	631.00	0.977	0.00339	0.000753	0.001920	0.00487
2.9	794.00	0.960	0.00345	0.000766	0.001950	0.00496
3.0	1000.00	0.960	0.00345	0.000766	0.001950	0.00496
3.1	1260.00	0.956	0.00347	0.000769	0.001960	0.00497
3.2	1580.00	0.946	0.00334	0.000756	0.001860	0.00482
3.3	2000.00	0.928	0.00308	0.000728	0.001650	0.00450
3.4	2510.00	0.909	0.00300	0.000727	0.001570	0.00442
3.5	3160.00	0.889	0.00306	0.000744	0.001600	0.00452
3.6	3980.00	0.855	0.00301	0.000751	0.001540	0.00448
3.7	5010.00	0.767	0.00305	0.000808	0.001460	0.00463
3.8	6310.00	0.685	0.00273	0.000800	0.001160	0.00430
3.9	7940.00	0.593	0.00301	0.000919	0.001210	0.00481
4.0	10000.00	0.498	0.00366	0.001140	0.001430	0.00589
4.1	12600.00	0.410	0.00299	0.001120	0.000793	0.00518
4.2	15800.00	0.326	0.00315	0.001290	0.000632	0.00567
4.3	20000.00	0.240	0.00373	0.001650	0.000501	0.00696

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.217	0.214	-0.2020	0.636
0.1	0.995	1.26	0.217	0.222	-0.2180	0.652
0.2	0.995	1.58	0.217	0.222	-0.2180	0.652
0.3	0.995	2.00	0.217	0.222	-0.2180	0.652
0.4	0.994	2.51	0.217	0.222	-0.2180	0.653
0.5	0.992	3.16	0.217	0.222	-0.2180	0.653
0.6	0.992	3.98	0.217	0.222	-0.2180	0.653
0.7	0.992	5.01	0.246	0.216	-0.1780	0.669
0.8	0.992	6.31	0.246	0.216	-0.1780	0.669
0.9	0.992	7.94	0.246	0.216	-0.1780	0.669
1.0	0.992	10.00	0.246	0.216	-0.1780	0.669
1.1	0.991	12.60	0.246	0.216	-0.1780	0.669
1.2	0.991	15.80	0.246	0.216	-0.1780	0.669
1.3	0.991	20.00	0.246	0.216	-0.1780	0.669
1.4	0.991	25.10	0.246	0.216	-0.1780	0.669
1.5	0.991	31.60	0.246	0.216	-0.1780	0.669
1.6	0.991	39.80	0.246	0.216	-0.1780	0.669
1.7	0.991	50.10	0.246	0.216	-0.1780	0.669
1.8	0.991	63.10	0.246	0.216	-0.1780	0.669
1.9	0.989	79.40	0.246	0.216	-0.1790	0.670
2.0	0.988	100.00	0.246	0.216	-0.1790	0.670
2.1	0.986	126.00	0.246	0.217	-0.1790	0.670
2.2	0.986	158.00	0.246	0.217	-0.1790	0.670
2.3	0.986	200.00	0.246	0.217	-0.1790	0.670
2.4	0.986	251.00	0.246	0.217	-0.1790	0.670
2.5	0.981	316.00	0.246	0.217	-0.1800	0.671
2.6	0.981	398.00	0.246	0.217	-0.1800	0.671
2.7	0.981	501.00	0.259	0.212	-0.1570	0.676
2.8	0.977	631.00	0.259	0.213	-0.1580	0.677
2.9	0.960	794.00	0.259	0.215	-0.1630	0.682
3.0	0.960	1000.00	0.259	0.215	-0.1630	0.682
3.1	0.956	1260.00	0.259	0.216	-0.1640	0.683
3.2	0.946	1580.00	0.278	0.212	-0.1370	0.693
3.3	0.928	2000.00	0.335	0.200	-0.0572	0.728
3.4	0.909	2510.00	0.339	0.200	-0.0527	0.730
3.5	0.889	3160.00	0.339	0.202	-0.0582	0.736
3.6	0.855	3980.00	0.339	0.204	-0.0607	0.738
3.7	0.767	5010.00	0.339	0.214	-0.0802	0.757
3.8	0.685	6310.00	0.339	0.212	-0.0775	0.755
3.9	0.593	7940.00	0.339	0.234	-0.1190	0.797
4.0	0.498	10000.00	0.339	0.275	-0.2000	0.877
4.1	0.410	12600.00	0.339	0.272	-0.1940	0.871
4.2	0.326	15800.00	0.339	0.304	-0.2570	0.934
4.3	0.240	20000.00	0.339	0.377	-0.4000	1.080

IgG3 V1V2 B.CaseA-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00361	0.000724	0.002190	0.00503
0.1	0.976	1.26	0.00341	0.000755	0.001930	0.00489
0.2	0.972	1.58	0.00341	0.000758	0.001930	0.00490
0.3	0.972	2.00	0.00341	0.000758	0.001930	0.00490
0.4	0.948	2.51	0.00339	0.000757	0.001900	0.00487
0.5	0.948	3.16	0.00339	0.000757	0.001900	0.00487
0.6	0.932	3.98	0.00339	0.000769	0.001880	0.00489
0.7	0.921	5.01	0.00339	0.000777	0.001860	0.00491
0.8	0.921	6.31	0.00339	0.000777	0.001860	0.00491
0.9	0.913	7.94	0.00335	0.000764	0.001860	0.00485
1.0	0.882	10.00	0.00335	0.000789	0.001810	0.00490
1.1	0.824	12.60	0.00335	0.000790	0.001810	0.00490
1.2	0.792	15.80	0.00335	0.000821	0.001740	0.00496
1.3	0.754	20.00	0.00335	0.000835	0.001720	0.00499
1.4	0.715	25.10	0.00335	0.000881	0.001630	0.00508
1.5	0.666	31.60	0.00335	0.000904	0.001580	0.00513
1.6	0.614	39.80	0.00324	0.000920	0.001440	0.00504
1.7	0.517	50.10	0.00324	0.001000	0.001280	0.00521
1.8	0.475	63.10	0.00324	0.001040	0.001190	0.00529
1.9	0.400	79.40	0.00316	0.001080	0.001040	0.00529
2.0	0.330	100.00	0.00316	0.001080	0.001040	0.00528
2.1	0.284	126.00	0.00316	0.001240	0.000727	0.00560
2.2	0.232	158.00	0.00316	0.001540	0.000139	0.00619
2.3	0.206	200.00	0.00316	0.001520	0.000189	0.00614
2.4	0.162	251.00	0.00316	0.002080	-0.000907	0.00724
2.5	0.132	316.00	0.00316	0.002880	-0.002490	0.00882

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	0.002100	0.00513
0.1	1.26	0.976	0.00341	0.000755	0.001930	0.00489
0.2	1.58	0.972	0.00342	0.000758	0.001930	0.00490
0.3	2.00	0.972	0.00342	0.000758	0.001930	0.00490
0.4	2.51	0.948	0.00334	0.000757	0.001860	0.00482
0.5	3.16	0.948	0.00334	0.000757	0.001860	0.00482
0.6	3.98	0.932	0.00339	0.000769	0.001890	0.00490
0.7	5.01	0.921	0.00343	0.000777	0.001900	0.00495
0.8	6.31	0.921	0.00343	0.000777	0.001900	0.00495
0.9	7.94	0.913	0.00330	0.000764	0.001800	0.00479
1.0	10.00	0.882	0.00340	0.000789	0.001850	0.00495
1.1	12.60	0.824	0.00324	0.000790	0.001690	0.00479
1.2	15.80	0.792	0.00336	0.000821	0.001750	0.00497
1.3	20.00	0.754	0.00332	0.000835	0.001680	0.00496
1.4	25.10	0.715	0.00349	0.000881	0.001770	0.00522
1.5	31.60	0.666	0.00338	0.000904	0.001610	0.00516
1.6	39.80	0.614	0.00323	0.000920	0.001420	0.00503
1.7	50.10	0.517	0.00326	0.001000	0.001290	0.00522
1.8	63.10	0.475	0.00324	0.001040	0.001190	0.00529
1.9	79.40	0.400	0.00289	0.001080	0.000762	0.00501
2.0	100.00	0.330	0.00229	0.001080	0.000171	0.00441
2.1	126.00	0.284	0.00263	0.001240	0.000191	0.00507
2.2	158.00	0.232	0.00323	0.001540	0.000202	0.00625
2.3	200.00	0.206	0.00285	0.001520	-0.000122	0.00583
2.4	251.00	0.162	0.00379	0.002080	-0.000282	0.00786
2.5	316.00	0.132	0.00448	0.002880	-0.001180	0.01010

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.220	0.214	-0.199	0.638
0.1	0.976	1.26	0.262	0.213	-0.156	0.680
0.2	0.972	1.58	0.262	0.214	-0.157	0.681
0.3	0.972	2.00	0.262	0.214	-0.157	0.681
0.4	0.948	2.51	0.268	0.213	-0.149	0.686
0.5	0.948	3.16	0.268	0.213	-0.149	0.686
0.6	0.932	3.98	0.268	0.215	-0.153	0.690
0.7	0.921	5.01	0.268	0.216	-0.155	0.692
0.8	0.921	6.31	0.268	0.216	-0.155	0.692
0.9	0.913	7.94	0.275	0.213	-0.143	0.693
1.0	0.882	10.00	0.275	0.217	-0.151	0.701
1.1	0.824	12.60	0.275	0.218	-0.151	0.702
1.2	0.792	15.80	0.275	0.223	-0.162	0.712
1.3	0.754	20.00	0.275	0.225	-0.167	0.717
1.4	0.715	25.10	0.275	0.233	-0.182	0.733
1.5	0.666	31.60	0.275	0.238	-0.190	0.741
1.6	0.614	39.80	0.299	0.238	-0.167	0.765
1.7	0.517	50.10	0.299	0.253	-0.196	0.795
1.8	0.475	63.10	0.300	0.261	-0.211	0.811
1.9	0.400	79.40	0.316	0.267	-0.206	0.839
2.0	0.330	100.00	0.316	0.266	-0.206	0.838
2.1	0.284	126.00	0.316	0.297	-0.267	0.899
2.2	0.232	158.00	0.316	0.357	-0.384	1.020
2.3	0.206	200.00	0.316	0.352	-0.374	1.010
2.4	0.162	251.00	0.316	0.467	-0.599	1.230
2.5	0.132	316.00	0.316	0.636	-0.931	1.560

IgG3 V1V2 AE.A244-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00361	0.000724	2.19e-03	0.00503
0.1	0.988	1.26	0.00350	0.000756	2.02e-03	0.00499
0.2	0.988	1.58	0.00350	0.000756	2.02e-03	0.00499
0.3	0.988	2.00	0.00350	0.000756	2.02e-03	0.00499
0.4	0.988	2.51	0.00350	0.000756	2.02e-03	0.00499
0.5	0.988	3.16	0.00350	0.000756	2.02e-03	0.00499
0.6	0.988	3.98	0.00350	0.000756	2.02e-03	0.00499
0.7	0.987	5.01	0.00350	0.000761	2.01e-03	0.00500
0.8	0.985	6.31	0.00350	0.000762	2.01e-03	0.00500
0.9	0.981	7.94	0.00350	0.000765	2.01e-03	0.00500
1.0	0.981	10.00	0.00350	0.000765	2.01e-03	0.00500
1.1	0.980	12.60	0.00350	0.000765	2.00e-03	0.00500
1.2	0.978	15.80	0.00350	0.000766	2.00e-03	0.00501
1.3	0.973	20.00	0.00350	0.000770	1.99e-03	0.00501
1.4	0.971	25.10	0.00341	0.000753	1.93e-03	0.00489
1.5	0.967	31.60	0.00341	0.000756	1.93e-03	0.00489
1.6	0.967	39.80	0.00341	0.000756	1.93e-03	0.00489
1.7	0.960	50.10	0.00341	0.000760	1.92e-03	0.00490
1.8	0.952	63.10	0.00332	0.000747	1.85e-03	0.00478
1.9	0.944	79.40	0.00332	0.000755	1.84e-03	0.00480
2.0	0.934	100.00	0.00322	0.000746	1.76e-03	0.00469
2.1	0.934	126.00	0.00315	0.000724	1.73e-03	0.00457
2.2	0.922	158.00	0.00315	0.000732	1.71e-03	0.00458
2.3	0.895	200.00	0.00315	0.000730	1.72e-03	0.00458
2.4	0.853	251.00	0.00315	0.000763	1.65e-03	0.00464
2.5	0.815	316.00	0.00315	0.000797	1.59e-03	0.00471
2.6	0.751	398.00	0.00315	0.000844	1.50e-03	0.00480
2.7	0.705	501.00	0.00315	0.000841	1.50e-03	0.00480
2.8	0.651	631.00	0.00281	0.000815	1.22e-03	0.00441
2.9	0.583	794.00	0.00281	0.000880	1.09e-03	0.00454
3.0	0.488	1000.00	0.00281	0.001010	8.35e-04	0.00479
3.1	0.404	1260.00	0.00281	0.001130	6.08e-04	0.00502
3.2	0.338	1580.00	0.00281	0.001260	3.52e-04	0.00527
3.3	0.277	2000.00	0.00281	0.001480	-7.81e-05	0.00571
3.4	0.206	2510.00	0.00281	0.002080	-1.26e-03	0.00689
3.5	0.172	3160.00	0.00281	0.002560	-2.21e-03	0.00784
3.6	0.133	3980.00	0.00281	0.002770	-2.62e-03	0.00825
3.7	0.114	5010.00	0.00281	0.002960	-2.99e-03	0.00862

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	2.10e-03	0.00513
0.1	1.26	0.988	0.00349	0.000756	2.01e-03	0.00498
0.2	1.58	0.988	0.00349	0.000756	2.01e-03	0.00498
0.3	2.00	0.988	0.00349	0.000756	2.01e-03	0.00498
0.4	2.51	0.988	0.00349	0.000756	2.01e-03	0.00498
0.5	3.16	0.988	0.00349	0.000756	2.01e-03	0.00498
0.6	3.98	0.988	0.00349	0.000756	2.01e-03	0.00498
0.7	5.01	0.987	0.00349	0.000761	2.00e-03	0.00498
0.8	6.31	0.985	0.00350	0.000762	2.00e-03	0.00499
0.9	7.94	0.981	0.00351	0.000765	2.01e-03	0.00501
1.0	10.00	0.981	0.00351	0.000765	2.01e-03	0.00501
1.1	12.60	0.980	0.00352	0.000765	2.02e-03	0.00502
1.2	15.80	0.978	0.00352	0.000766	2.02e-03	0.00502
1.3	20.00	0.973	0.00354	0.000770	2.03e-03	0.00504
1.4	25.10	0.971	0.00340	0.000753	1.92e-03	0.00487
1.5	31.60	0.967	0.00341	0.000756	1.93e-03	0.00489
1.6	39.80	0.967	0.00341	0.000756	1.93e-03	0.00489
1.7	50.10	0.960	0.00343	0.000760	1.94e-03	0.00492
1.8	63.10	0.952	0.00330	0.000747	1.84e-03	0.00477
1.9	79.40	0.944	0.00333	0.000755	1.85e-03	0.00481
2.0	100.00	0.934	0.00322	0.000746	1.76e-03	0.00469
2.1	126.00	0.934	0.00306	0.000724	1.64e-03	0.00448
2.2	158.00	0.922	0.00309	0.000732	1.66e-03	0.00453
2.3	200.00	0.895	0.00301	0.000730	1.58e-03	0.00444
2.4	251.00	0.853	0.00313	0.000763	1.64e-03	0.00463
2.5	316.00	0.815	0.00326	0.000797	1.70e-03	0.00482
2.6	398.00	0.751	0.00335	0.000844	1.70e-03	0.00501
2.7	501.00	0.705	0.00316	0.000841	1.51e-03	0.00481
2.8	631.00	0.651	0.00268	0.000815	1.08e-03	0.00428
2.9	794.00	0.583	0.00276	0.000880	1.04e-03	0.00449
3.0	1000.00	0.488	0.00301	0.001010	1.03e-03	0.00499
3.1	1260.00	0.404	0.00299	0.001130	7.84e-04	0.00520
3.2	1580.00	0.338	0.00313	0.001260	6.65e-04	0.00559
3.3	2000.00	0.277	0.00339	0.001480	4.97e-04	0.00628
3.4	2510.00	0.206	0.00470	0.002080	6.18e-04	0.00877
3.5	3160.00	0.172	0.00512	0.002560	9.62e-05	0.01010
3.6	3980.00	0.133	0.00495	0.002770	-4.85e-04	0.01040
3.7	5010.00	0.114	0.00463	0.002960	-1.17e-03	0.01040

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.220	0.214	-0.1990	0.638
0.1	0.988	1.26	0.243	0.216	-0.1800	0.666
0.2	0.988	1.58	0.243	0.216	-0.1800	0.666
0.3	0.988	2.00	0.243	0.216	-0.1800	0.666
0.4	0.988	2.51	0.243	0.216	-0.1800	0.666
0.5	0.988	3.16	0.243	0.216	-0.1800	0.666
0.6	0.988	3.98	0.243	0.216	-0.1800	0.666
0.7	0.987	5.01	0.243	0.217	-0.1820	0.667
0.8	0.985	6.31	0.243	0.217	-0.1820	0.668
0.9	0.981	7.94	0.243	0.217	-0.1830	0.669
1.0	0.981	10.00	0.243	0.217	-0.1830	0.669
1.1	0.980	12.60	0.243	0.217	-0.1830	0.669
1.2	0.978	15.80	0.243	0.217	-0.1830	0.669
1.3	0.973	20.00	0.243	0.218	-0.1850	0.670
1.4	0.971	25.10	0.263	0.213	-0.1540	0.680
1.5	0.967	31.60	0.263	0.213	-0.1550	0.681
1.6	0.967	39.80	0.263	0.213	-0.1550	0.681
1.7	0.960	50.10	0.263	0.214	-0.1560	0.682
1.8	0.952	63.10	0.283	0.210	-0.1280	0.694
1.9	0.944	79.40	0.283	0.211	-0.1300	0.696
2.0	0.934	100.00	0.303	0.207	-0.1020	0.709
2.1	0.934	126.00	0.319	0.201	-0.0753	0.714
2.2	0.922	158.00	0.319	0.203	-0.0780	0.717
2.3	0.895	200.00	0.319	0.202	-0.0772	0.716
2.4	0.853	251.00	0.319	0.208	-0.0880	0.727
2.5	0.815	316.00	0.319	0.214	-0.0996	0.738
2.6	0.751	398.00	0.319	0.222	-0.1160	0.755
2.7	0.705	501.00	0.319	0.222	-0.1150	0.754
2.8	0.651	631.00	0.392	0.209	-0.0185	0.802
2.9	0.583	794.00	0.392	0.221	-0.0419	0.826
3.0	0.488	1000.00	0.392	0.246	-0.0898	0.874
3.1	0.404	1260.00	0.392	0.268	-0.1340	0.918
3.2	0.338	1580.00	0.392	0.294	-0.1840	0.968
3.3	0.277	2000.00	0.392	0.338	-0.2710	1.060
3.4	0.206	2510.00	0.392	0.464	-0.5170	1.300
3.5	0.172	3160.00	0.392	0.566	-0.7170	1.500
3.6	0.133	3980.00	0.392	0.610	-0.8040	1.590
3.7	0.114	5010.00	0.392	0.650	-0.8820	1.670

IgG3 V1V2 C.1086-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00365	0.000724	0.002230	0.00507
0.1	0.983	1.26	0.00365	0.000780	0.002120	0.00518
0.2	0.983	1.58	0.00365	0.000780	0.002120	0.00518
0.3	0.983	2.00	0.00365	0.000780	0.002120	0.00518
0.4	0.983	2.51	0.00365	0.000780	0.002120	0.00518
0.5	0.979	3.16	0.00365	0.000784	0.002110	0.00518
0.6	0.979	3.98	0.00352	0.000767	0.002020	0.00502
0.7	0.974	5.01	0.00342	0.000752	0.001940	0.00489
0.8	0.970	6.31	0.00342	0.000754	0.001940	0.00489
0.9	0.963	7.94	0.00342	0.000761	0.001920	0.00491
1.0	0.959	10.00	0.00342	0.000764	0.001920	0.00491
1.1	0.953	12.60	0.00333	0.000749	0.001860	0.00480
1.2	0.942	15.80	0.00333	0.000756	0.001850	0.00481
1.3	0.942	20.00	0.00333	0.000756	0.001850	0.00481
1.4	0.938	25.10	0.00326	0.000741	0.001810	0.00471
1.5	0.929	31.60	0.00326	0.000750	0.001790	0.00473
1.6	0.915	39.80	0.00326	0.000760	0.001770	0.00475
1.7	0.903	50.10	0.00326	0.000769	0.001750	0.00477
1.8	0.870	63.10	0.00319	0.000748	0.001720	0.00465
1.9	0.839	79.40	0.00319	0.000751	0.001710	0.00466
2.0	0.763	100.00	0.00319	0.000831	0.001560	0.00481
2.1	0.706	126.00	0.00319	0.000875	0.001470	0.00490
2.2	0.653	158.00	0.00295	0.000836	0.001320	0.00459
2.3	0.614	200.00	0.00295	0.000900	0.001190	0.00472
2.4	0.551	251.00	0.00295	0.000943	0.001110	0.00480
2.5	0.469	316.00	0.00295	0.000979	0.001030	0.00487
2.6	0.378	398.00	0.00295	0.001280	0.000442	0.00547
2.7	0.329	501.00	0.00295	0.001430	0.000143	0.00576
2.8	0.251	631.00	0.00295	0.001780	-0.000533	0.00644
2.9	0.193	794.00	0.00295	0.002270	-0.001490	0.00740
3.0	0.176	1000.00	0.00295	0.002470	-0.001890	0.00780
3.1	0.134	1260.00	0.00295	0.002450	-0.001840	0.00775

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	0.002100	0.00513
0.1	1.26	0.983	0.00365	0.000780	0.002120	0.00518
0.2	1.58	0.983	0.00365	0.000780	0.002120	0.00518
0.3	2.00	0.983	0.00365	0.000780	0.002120	0.00518
0.4	2.51	0.983	0.00365	0.000780	0.002120	0.00518
0.5	3.16	0.979	0.00367	0.000784	0.002130	0.00520
0.6	3.98	0.979	0.00352	0.000767	0.002020	0.00502
0.7	5.01	0.974	0.00339	0.000752	0.001910	0.00486
0.8	6.31	0.970	0.00340	0.000754	0.001920	0.00488
0.9	7.94	0.963	0.00343	0.000761	0.001940	0.00492
1.0	10.00	0.959	0.00344	0.000764	0.001950	0.00494
1.1	12.60	0.953	0.00331	0.000749	0.001840	0.00478
1.2	15.80	0.942	0.00334	0.000756	0.001860	0.00482
1.3	20.00	0.942	0.00334	0.000756	0.001860	0.00482
1.4	25.10	0.938	0.00320	0.000741	0.001750	0.00466
1.5	31.60	0.929	0.00324	0.000750	0.001770	0.00471
1.6	39.80	0.915	0.00328	0.000760	0.001790	0.00477
1.7	50.10	0.903	0.00332	0.000769	0.001810	0.00483
1.8	63.10	0.870	0.00308	0.000748	0.001610	0.00454
1.9	79.40	0.839	0.00300	0.000751	0.001530	0.00448
2.0	100.00	0.763	0.00331	0.000831	0.001680	0.00494
2.1	126.00	0.706	0.00338	0.000875	0.001660	0.00509
2.2	158.00	0.653	0.00285	0.000836	0.001210	0.00448
2.3	200.00	0.614	0.00306	0.000900	0.001290	0.00482
2.4	251.00	0.551	0.00295	0.000943	0.001110	0.00480
2.5	316.00	0.469	0.00277	0.000979	0.000852	0.00469
2.6	398.00	0.378	0.00354	0.001280	0.001030	0.00606
2.7	501.00	0.329	0.00374	0.001430	0.000930	0.00655
2.8	631.00	0.251	0.00429	0.001780	0.000802	0.00777
2.9	794.00	0.193	0.00507	0.002270	0.000624	0.00952
3.0	1000.00	0.176	0.00497	0.002470	0.000124	0.00981
3.1	1260.00	0.134	0.00389	0.002450	-0.000902	0.00868

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.212	0.215	-0.2080	0.633
0.1	0.983	1.26	0.212	0.224	-0.2260	0.650
0.2	0.983	1.58	0.212	0.224	-0.2260	0.650
0.3	0.983	2.00	0.212	0.224	-0.2260	0.650
0.4	0.983	2.51	0.212	0.224	-0.2260	0.650
0.5	0.979	3.16	0.212	0.224	-0.2270	0.651
0.6	0.979	3.98	0.239	0.218	-0.1880	0.666
0.7	0.974	5.01	0.262	0.213	-0.1550	0.679
0.8	0.970	6.31	0.262	0.213	-0.1560	0.680
0.9	0.963	7.94	0.262	0.214	-0.1580	0.682
1.0	0.959	10.00	0.262	0.215	-0.1590	0.683
1.1	0.953	12.60	0.281	0.210	-0.1310	0.692
1.2	0.942	15.80	0.281	0.211	-0.1340	0.695
1.3	0.942	20.00	0.281	0.211	-0.1340	0.695
1.4	0.938	25.10	0.295	0.207	-0.1100	0.701
1.5	0.929	31.60	0.295	0.209	-0.1130	0.704
1.6	0.915	39.80	0.295	0.210	-0.1160	0.707
1.7	0.903	50.10	0.295	0.212	-0.1200	0.710
1.8	0.870	63.10	0.312	0.206	-0.0927	0.716
1.9	0.839	79.40	0.312	0.207	-0.0938	0.717
2.0	0.763	100.00	0.312	0.221	-0.1210	0.744
2.1	0.706	126.00	0.312	0.228	-0.1360	0.759
2.2	0.653	158.00	0.362	0.216	-0.0621	0.786
2.3	0.614	200.00	0.362	0.228	-0.0851	0.808
2.4	0.551	251.00	0.362	0.236	-0.1010	0.824
2.5	0.469	316.00	0.362	0.243	-0.1140	0.837
2.6	0.378	398.00	0.362	0.301	-0.2290	0.952
2.7	0.329	501.00	0.362	0.332	-0.2890	1.010
2.8	0.251	631.00	0.362	0.402	-0.4270	1.150
2.9	0.193	794.00	0.362	0.504	-0.6270	1.350
3.0	0.176	1000.00	0.362	0.547	-0.7100	1.430
3.1	0.134	1260.00	0.362	0.542	-0.7000	1.420

IgG3 V1V2 C.1086-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00361	0.000724	2.19e-03	0.00503
0.1	0.9840	1.26	0.00355	0.000765	2.05e-03	0.00505
0.2	0.9840	1.58	0.00355	0.000765	2.05e-03	0.00505
0.3	0.9840	2.00	0.00355	0.000765	2.05e-03	0.00505
0.4	0.9790	2.51	0.00355	0.000768	2.04e-03	0.00505
0.5	0.9770	3.16	0.00355	0.000768	2.04e-03	0.00505
0.6	0.9770	3.98	0.00355	0.000768	2.04e-03	0.00505
0.7	0.9720	5.01	0.00355	0.000773	2.03e-03	0.00506
0.8	0.9650	6.31	0.00355	0.000777	2.02e-03	0.00507
0.9	0.9650	7.94	0.00355	0.000777	2.02e-03	0.00507
1.0	0.9590	10.00	0.00355	0.000782	2.02e-03	0.00508
1.1	0.9510	12.60	0.00355	0.000788	2.00e-03	0.00509
1.2	0.9480	15.80	0.00348	0.000772	1.96e-03	0.00499
1.3	0.9470	20.00	0.00336	0.000753	1.88e-03	0.00484
1.4	0.9410	25.10	0.00336	0.000756	1.88e-03	0.00484
1.5	0.9190	31.60	0.00336	0.000775	1.84e-03	0.00488
1.6	0.9070	39.80	0.00335	0.000766	1.85e-03	0.00485
1.7	0.8850	50.10	0.00335	0.000788	1.81e-03	0.00489
1.8	0.8690	63.10	0.00327	0.000759	1.78e-03	0.00475
1.9	0.8690	79.40	0.00327	0.000759	1.78e-03	0.00475
2.0	0.8370	100.00	0.00327	0.000761	1.77e-03	0.00476
2.1	0.7940	126.00	0.00327	0.000786	1.73e-03	0.00481
2.2	0.7390	158.00	0.00327	0.000819	1.66e-03	0.00487
2.3	0.6800	200.00	0.00327	0.000843	1.61e-03	0.00492
2.4	0.6430	251.00	0.00327	0.000887	1.53e-03	0.00501
2.5	0.5840	316.00	0.00327	0.000970	1.37e-03	0.00517
2.6	0.5210	398.00	0.00327	0.001010	1.29e-03	0.00524
2.7	0.4470	501.00	0.00327	0.001180	9.55e-04	0.00558
2.8	0.3610	631.00	0.00327	0.001510	3.12e-04	0.00622
2.9	0.2960	794.00	0.00327	0.001660	2.18e-05	0.00651
3.0	0.2490	1000.00	0.00327	0.001980	-6.09e-04	0.00714
3.1	0.2030	1260.00	0.00327	0.002240	-1.12e-03	0.00765
3.2	0.1500	1580.00	0.00327	0.002330	-1.30e-03	0.00784
3.3	0.1200	2000.00	0.00327	0.002490	-1.62e-03	0.00816
3.4	0.0937	2510.00	0.00327	0.003900	-4.39e-03	0.01090
3.5	0.0656	3160.00	0.00327	0.006600	-9.66e-03	0.01620

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00361	0.000724	0.002100	0.00513
0.1	1.26	0.9840	0.00352	0.000765	0.002020	0.00501
0.2	1.58	0.9840	0.00352	0.000765	0.002020	0.00501
0.3	2.00	0.9840	0.00352	0.000765	0.002020	0.00501
0.4	2.51	0.9790	0.00353	0.000768	0.002020	0.00503
0.5	3.16	0.9770	0.00353	0.000768	0.002020	0.00503
0.6	3.98	0.9770	0.00353	0.000768	0.002020	0.00503
0.7	5.01	0.9720	0.00355	0.000773	0.002030	0.00506
0.8	6.31	0.9650	0.00357	0.000777	0.002040	0.00509
0.9	7.94	0.9650	0.00357	0.000777	0.002040	0.00509
1.0	10.00	0.9590	0.00359	0.000782	0.002060	0.00512
1.1	12.60	0.9510	0.00362	0.000788	0.002070	0.00516
1.2	15.80	0.9480	0.00348	0.000772	0.001960	0.00499
1.3	20.00	0.9470	0.00333	0.000753	0.001850	0.00480
1.4	25.10	0.9410	0.00334	0.000756	0.001860	0.00482
1.5	31.60	0.9190	0.00342	0.000775	0.001900	0.00493
1.6	39.80	0.9070	0.00331	0.000766	0.001800	0.00481
1.7	50.10	0.8850	0.00339	0.000788	0.001850	0.00494
1.8	63.10	0.8690	0.00312	0.000759	0.001630	0.00461
1.9	79.40	0.8690	0.00312	0.000759	0.001630	0.00461
2.0	100.00	0.8370	0.00305	0.000761	0.001560	0.00454
2.1	126.00	0.7940	0.00305	0.000786	0.001510	0.00460
2.2	158.00	0.7390	0.00308	0.000819	0.001480	0.00469
2.3	200.00	0.6800	0.00297	0.000843	0.001310	0.00462
2.4	251.00	0.6430	0.00312	0.000887	0.001380	0.00486
2.5	316.00	0.5840	0.00340	0.000970	0.001500	0.00530
2.6	398.00	0.5210	0.00328	0.001010	0.001300	0.00525
2.7	501.00	0.4470	0.00366	0.001180	0.001340	0.00597
2.8	631.00	0.3610	0.00458	0.001510	0.001630	0.00754
2.9	794.00	0.2960	0.00453	0.001660	0.001280	0.00777
3.0	1000.00	0.2490	0.00464	0.001980	0.000768	0.00852
3.1	1260.00	0.2030	0.00528	0.002240	0.000896	0.00967
3.2	1580.00	0.1500	0.00429	0.002330	-0.000284	0.00886
3.3	2000.00	0.1200	0.00453	0.002490	-0.000354	0.00942
3.4	2510.00	0.0937	0.00681	0.003900	-0.000840	0.01450
3.5	3160.00	0.0656	0.01110	0.006600	-0.001830	0.02400

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.220	0.214	-0.199	0.638
0.1	0.9840	1.26	0.233	0.218	-0.195	0.662
0.2	0.9840	1.58	0.233	0.218	-0.195	0.662
0.3	0.9840	2.00	0.233	0.218	-0.195	0.662
0.4	0.9790	2.51	0.233	0.219	-0.195	0.662
0.5	0.9770	3.16	0.233	0.219	-0.196	0.663
0.6	0.9770	3.98	0.233	0.219	-0.196	0.663
0.7	0.9720	5.01	0.233	0.220	-0.197	0.664
0.8	0.9650	6.31	0.233	0.220	-0.199	0.666
0.9	0.9650	7.94	0.233	0.220	-0.199	0.666
1.0	0.9590	10.00	0.233	0.221	-0.200	0.667
1.1	0.9510	12.60	0.233	0.222	-0.202	0.669
1.2	0.9480	15.80	0.249	0.218	-0.178	0.675
1.3	0.9470	20.00	0.274	0.212	-0.141	0.689
1.4	0.9410	25.10	0.274	0.212	-0.142	0.689
1.5	0.9190	31.60	0.274	0.215	-0.148	0.696
1.6	0.9070	39.80	0.276	0.213	-0.142	0.694
1.7	0.8850	50.10	0.276	0.217	-0.150	0.702
1.8	0.8690	63.10	0.294	0.210	-0.118	0.706
1.9	0.8690	79.40	0.294	0.210	-0.118	0.706
2.0	0.8370	100.00	0.294	0.211	-0.119	0.707
2.1	0.7940	126.00	0.294	0.215	-0.127	0.715
2.2	0.7390	158.00	0.294	0.220	-0.138	0.726
2.3	0.6800	200.00	0.294	0.225	-0.146	0.734
2.4	0.6430	251.00	0.294	0.232	-0.162	0.750
2.5	0.5840	316.00	0.294	0.247	-0.191	0.779
2.6	0.5210	398.00	0.294	0.255	-0.205	0.793
2.7	0.4470	501.00	0.294	0.287	-0.268	0.856
2.8	0.3610	631.00	0.294	0.351	-0.394	0.983
2.9	0.2960	794.00	0.294	0.381	-0.453	1.040
3.0	0.2490	1000.00	0.294	0.447	-0.582	1.170
3.1	0.2030	1260.00	0.294	0.501	-0.688	1.280
3.2	0.1500	1580.00	0.294	0.521	-0.727	1.310
3.3	0.1200	2000.00	0.294	0.555	-0.793	1.380
3.4	0.0937	2510.00	0.294	0.854	-1.380	1.970
3.5	0.0656	3160.00	0.294	1.430	-2.510	3.100

IgG_V1V2_CaseA2_elisa

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
-0.903	1.000	0.125	0.00361	0.000724	2.19e-03	0.00503
-0.803	0.980	0.157	0.00352	0.000766	2.02e-03	0.00502
-0.703	0.914	0.198	0.00346	0.000785	1.92e-03	0.00500
-0.603	0.783	0.249	0.00315	0.000809	1.56e-03	0.00473
-0.503	0.672	0.314	0.00236	0.000746	8.96e-04	0.00382
-0.403	0.486	0.395	0.00234	0.000849	6.72e-04	0.00400
-0.303	0.330	0.498	0.00234	0.001210	-2.56e-05	0.00470

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
-0.903	0.125	1.000	0.00361	0.000724	0.002100	0.00513
-0.803	0.157	0.980	0.00352	0.000766	0.002020	0.00502
-0.703	0.198	0.914	0.00346	0.000785	0.001920	0.00500
-0.603	0.249	0.783	0.00315	0.000809	0.001560	0.00473
-0.503	0.314	0.672	0.00236	0.000746	0.000896	0.00382
-0.403	0.395	0.486	0.00215	0.000849	0.000481	0.00381
-0.303	0.498	0.330	0.00253	0.001210	0.000166	0.00489

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
-0.903	1.000	0.125	0.220	0.214	-0.1990	0.638
-0.803	0.980	0.157	0.239	0.218	-0.1870	0.666
-0.703	0.914	0.198	0.252	0.220	-0.1780	0.682
-0.603	0.783	0.249	0.320	0.216	-0.1030	0.743
-0.503	0.672	0.314	0.491	0.187	0.1240	0.857
-0.403	0.486	0.395	0.495	0.206	0.0908	0.899
-0.303	0.330	0.498	0.495	0.277	-0.0478	1.040

IgG_gp70.V1V2CaseA2

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00361	0.000724	0.002190	0.00503
0.1	0.995	1.26	0.00349	0.000757	0.002010	0.00498
0.2	0.995	1.58	0.00349	0.000757	0.002010	0.00498
0.3	0.995	2.00	0.00349	0.000757	0.002010	0.00498
0.4	0.994	2.51	0.00349	0.000758	0.002010	0.00498
0.5	0.994	3.16	0.00349	0.000758	0.002010	0.00498
0.6	0.985	3.98	0.00349	0.000764	0.002000	0.00499
0.7	0.985	5.01	0.00349	0.000764	0.002000	0.00499
0.8	0.985	6.31	0.00349	0.000764	0.002000	0.00499
0.9	0.985	7.94	0.00349	0.000764	0.002000	0.00499
1.0	0.978	10.00	0.00349	0.000768	0.001990	0.00500
1.1	0.972	12.60	0.00342	0.000754	0.001940	0.00489
1.2	0.963	15.80	0.00342	0.000761	0.001920	0.00491
1.3	0.957	20.00	0.00330	0.000746	0.001830	0.00476
1.4	0.945	25.10	0.00319	0.000738	0.001740	0.00463
1.5	0.930	31.60	0.00310	0.000730	0.001670	0.00453
1.6	0.922	39.80	0.00310	0.000733	0.001670	0.00454
1.7	0.914	50.10	0.00310	0.000742	0.001650	0.00456
1.8	0.895	63.10	0.00291	0.000718	0.001510	0.00432
1.9	0.855	79.40	0.00291	0.000729	0.001490	0.00434
2.0	0.805	100.00	0.00291	0.000776	0.001390	0.00444
2.1	0.741	126.00	0.00263	0.000743	0.001170	0.00409
2.2	0.681	158.00	0.00250	0.000760	0.001010	0.00399
2.3	0.653	200.00	0.00242	0.000771	0.000913	0.00393
2.4	0.591	251.00	0.00212	0.000710	0.000727	0.00351
2.5	0.520	316.00	0.00212	0.000824	0.000503	0.00373
2.6	0.456	398.00	0.00212	0.000842	0.000468	0.00377
2.7	0.375	501.00	0.00212	0.000957	0.000242	0.00399
2.8	0.293	631.00	0.00191	0.001010	-0.000080	0.00390

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	2.10e-03	0.00513
0.1	1.26	0.995	0.00348	0.000757	1.99e-03	0.00496
0.2	1.58	0.995	0.00348	0.000757	1.99e-03	0.00496
0.3	2.00	0.995	0.00348	0.000757	1.99e-03	0.00496
0.4	2.51	0.994	0.00348	0.000758	1.99e-03	0.00497
0.5	3.16	0.994	0.00348	0.000758	1.99e-03	0.00497
0.6	3.98	0.985	0.00351	0.000764	2.01e-03	0.00501
0.7	5.01	0.985	0.00351	0.000764	2.01e-03	0.00501
0.8	6.31	0.985	0.00351	0.000764	2.01e-03	0.00501
0.9	7.94	0.985	0.00351	0.000764	2.01e-03	0.00501
1.0	10.00	0.978	0.00353	0.000768	2.02e-03	0.00503
1.1	12.60	0.972	0.00340	0.000754	1.92e-03	0.00487
1.2	15.80	0.963	0.00343	0.000761	1.94e-03	0.00493
1.3	20.00	0.957	0.00330	0.000746	1.83e-03	0.00476
1.4	25.10	0.945	0.00319	0.000738	1.74e-03	0.00463
1.5	31.60	0.930	0.00308	0.000730	1.65e-03	0.00452
1.6	39.80	0.922	0.00309	0.000733	1.66e-03	0.00453
1.7	50.10	0.914	0.00313	0.000742	1.68e-03	0.00458
1.8	63.10	0.895	0.00288	0.000718	1.48e-03	0.00429
1.9	79.40	0.855	0.00285	0.000729	1.42e-03	0.00428
2.0	100.00	0.805	0.00302	0.000776	1.50e-03	0.00454
2.1	126.00	0.741	0.00263	0.000743	1.17e-03	0.00409
2.2	158.00	0.681	0.00250	0.000760	1.01e-03	0.00399
2.3	200.00	0.653	0.00242	0.000771	9.13e-04	0.00393
2.4	251.00	0.591	0.00192	0.000710	5.27e-04	0.00331
2.5	316.00	0.520	0.00222	0.000824	6.05e-04	0.00384
2.6	398.00	0.456	0.00212	0.000842	4.71e-04	0.00377
2.7	501.00	0.375	0.00221	0.000957	3.38e-04	0.00409
2.8	631.00	0.293	0.00191	0.001010	-7.99e-05	0.00390

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.220	0.214	-0.1990	0.638
0.1	0.995	1.26	0.245	0.216	-0.1780	0.668
0.2	0.995	1.58	0.245	0.216	-0.1780	0.668
0.3	0.995	2.00	0.245	0.216	-0.1780	0.668
0.4	0.994	2.51	0.245	0.216	-0.1780	0.668
0.5	0.994	3.16	0.245	0.216	-0.1780	0.668
0.6	0.985	3.98	0.245	0.217	-0.1800	0.670
0.7	0.985	5.01	0.245	0.217	-0.1800	0.670
0.8	0.985	6.31	0.245	0.217	-0.1800	0.670
0.9	0.985	7.94	0.245	0.217	-0.1800	0.670
1.0	0.978	10.00	0.245	0.218	-0.1820	0.671
1.1	0.972	12.60	0.262	0.213	-0.1560	0.680
1.2	0.963	15.80	0.262	0.214	-0.1580	0.682
1.3	0.957	20.00	0.288	0.209	-0.1210	0.697
1.4	0.945	25.10	0.311	0.205	-0.0900	0.712
1.5	0.930	31.60	0.329	0.201	-0.0649	0.724
1.6	0.922	39.80	0.329	0.202	-0.0658	0.725
1.7	0.914	50.10	0.329	0.203	-0.0687	0.728
1.8	0.895	63.10	0.370	0.195	-0.0110	0.751
1.9	0.855	79.40	0.370	0.196	-0.0147	0.755
2.0	0.805	100.00	0.370	0.205	-0.0309	0.771
2.1	0.741	126.00	0.432	0.192	0.0549	0.808
2.2	0.681	158.00	0.461	0.192	0.0834	0.838
2.3	0.653	200.00	0.476	0.193	0.0979	0.854
2.4	0.591	251.00	0.542	0.175	0.1980	0.886
2.5	0.520	316.00	0.542	0.197	0.1550	0.929
2.6	0.456	398.00	0.542	0.201	0.1480	0.936
2.7	0.375	501.00	0.542	0.224	0.1040	0.981
2.8	0.293	631.00	0.587	0.232	0.1320	1.040

IgG_A244D11K169

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00361	0.000724	0.002190	0.00503
0.1	0.994	1.26	0.00349	0.000758	0.002000	0.00497
0.2	0.994	1.58	0.00349	0.000758	0.002000	0.00497
0.3	0.994	2.00	0.00349	0.000758	0.002000	0.00497
0.4	0.994	2.51	0.00349	0.000758	0.002000	0.00497
0.5	0.994	3.16	0.00349	0.000758	0.002000	0.00497
0.6	0.994	3.98	0.00349	0.000758	0.002000	0.00497
0.7	0.992	5.01	0.00349	0.000759	0.002000	0.00498
0.8	0.992	6.31	0.00349	0.000759	0.002000	0.00498
0.9	0.992	7.94	0.00349	0.000759	0.002000	0.00498
1.0	0.992	10.00	0.00349	0.000759	0.002000	0.00498
1.1	0.992	12.60	0.00349	0.000759	0.002000	0.00498
1.2	0.992	15.80	0.00349	0.000759	0.002000	0.00498
1.3	0.992	20.00	0.00349	0.000759	0.002000	0.00498
1.4	0.991	25.10	0.00349	0.000760	0.002000	0.00498
1.5	0.991	31.60	0.00349	0.000760	0.002000	0.00498
1.6	0.989	39.80	0.00349	0.000760	0.002000	0.00498
1.7	0.989	50.10	0.00349	0.000760	0.002000	0.00498
1.8	0.988	63.10	0.00349	0.000761	0.002000	0.00498
1.9	0.988	79.40	0.00349	0.000761	0.002000	0.00498
2.0	0.986	100.00	0.00349	0.000763	0.001990	0.00498
2.1	0.986	126.00	0.00349	0.000763	0.001990	0.00498
2.2	0.985	158.00	0.00349	0.000764	0.001990	0.00499
2.3	0.985	200.00	0.00349	0.000764	0.001990	0.00499
2.4	0.985	251.00	0.00349	0.000764	0.001990	0.00499
2.5	0.985	316.00	0.00349	0.000764	0.001990	0.00499
2.6	0.985	398.00	0.00349	0.000764	0.001990	0.00499
2.7	0.984	501.00	0.00346	0.000746	0.002000	0.00492
2.8	0.970	631.00	0.00346	0.000757	0.001980	0.00494
2.9	0.959	794.00	0.00346	0.000763	0.001960	0.00495
3.0	0.947	1000.00	0.00346	0.000772	0.001950	0.00497
3.1	0.912	1260.00	0.00346	0.000784	0.001920	0.00500
3.2	0.860	1580.00	0.00346	0.000810	0.001870	0.00505
3.3	0.804	2000.00	0.00346	0.000823	0.001850	0.00507
3.4	0.706	2510.00	0.00346	0.000862	0.001770	0.00515
3.5	0.582	3160.00	0.00346	0.001100	0.001300	0.00562
3.6	0.428	3980.00	0.00346	0.001240	0.001020	0.00590
3.7	0.385	5010.00	0.00346	0.001200	0.001110	0.00581
3.8	0.272	6310.00	0.00346	0.001340	0.000831	0.00609
3.9	0.149	7940.00	0.00346	0.002320	-0.001090	0.00801
4.0	0.085	10000.00	0.00346	0.003790	-0.003980	0.01090

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	0.002100	0.00513
0.1	1.26	0.994	0.00348	0.000758	0.001990	0.00497
0.2	1.58	0.994	0.00348	0.000758	0.001990	0.00497
0.3	2.00	0.994	0.00348	0.000758	0.001990	0.00497
0.4	2.51	0.994	0.00348	0.000758	0.001990	0.00497
0.5	3.16	0.994	0.00348	0.000758	0.001990	0.00497
0.6	3.98	0.994	0.00348	0.000758	0.001990	0.00497
0.7	5.01	0.992	0.00348	0.000759	0.001990	0.00497
0.8	6.31	0.992	0.00348	0.000759	0.001990	0.00497
0.9	7.94	0.992	0.00348	0.000759	0.001990	0.00497
1.0	10.00	0.992	0.00348	0.000759	0.001990	0.00497
1.1	12.60	0.992	0.00348	0.000759	0.001990	0.00497
1.2	15.80	0.992	0.00348	0.000759	0.001990	0.00497
1.3	20.00	0.992	0.00348	0.000759	0.001990	0.00497
1.4	25.10	0.991	0.00348	0.000760	0.002000	0.00497
1.5	31.60	0.991	0.00348	0.000760	0.002000	0.00497
1.6	39.80	0.989	0.00349	0.000760	0.002000	0.00498
1.7	50.10	0.989	0.00349	0.000760	0.002000	0.00498
1.8	63.10	0.988	0.00349	0.000761	0.002000	0.00498
1.9	79.40	0.988	0.00349	0.000761	0.002000	0.00498
2.0	100.00	0.986	0.00350	0.000763	0.002010	0.00500
2.1	126.00	0.986	0.00350	0.000763	0.002010	0.00500
2.2	158.00	0.985	0.00350	0.000764	0.002010	0.00500
2.3	200.00	0.985	0.00350	0.000764	0.002010	0.00500
2.4	251.00	0.985	0.00350	0.000764	0.002010	0.00500
2.5	316.00	0.985	0.00350	0.000764	0.002010	0.00500
2.6	398.00	0.985	0.00350	0.000764	0.002010	0.00500
2.7	501.00	0.984	0.00336	0.000746	0.001900	0.00482
2.8	631.00	0.970	0.00341	0.000757	0.001930	0.00490
2.9	794.00	0.959	0.00344	0.000763	0.001940	0.00494
3.0	1000.00	0.947	0.00348	0.000772	0.001970	0.00499
3.1	1260.00	0.912	0.00346	0.000784	0.001920	0.00499
3.2	1580.00	0.860	0.00348	0.000810	0.001890	0.00507
3.3	2000.00	0.804	0.00337	0.000823	0.001750	0.00498
3.4	2510.00	0.706	0.00322	0.000862	0.001530	0.00491
3.5	3160.00	0.582	0.00370	0.001100	0.001540	0.00587
3.6	3980.00	0.428	0.00379	0.001240	0.001360	0.00623
3.7	5010.00	0.385	0.00330	0.001200	0.000953	0.00566
3.8	6310.00	0.272	0.00328	0.001340	0.000656	0.00591
3.9	7940.00	0.149	0.00511	0.002320	0.000562	0.00966
4.0	10000.00	0.085	0.00562	0.003790	-0.001820	0.01310

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.220	0.214	-0.199	0.638
0.1	0.994	1.26	0.246	0.216	-0.177	0.669
0.2	0.994	1.58	0.246	0.216	-0.177	0.669
0.3	0.994	2.00	0.246	0.216	-0.177	0.669
0.4	0.994	2.51	0.246	0.216	-0.177	0.669
0.5	0.994	3.16	0.246	0.216	-0.177	0.669
0.6	0.994	3.98	0.246	0.216	-0.177	0.669
0.7	0.992	5.01	0.246	0.216	-0.177	0.669
0.8	0.992	6.31	0.246	0.216	-0.177	0.669
0.9	0.992	7.94	0.246	0.216	-0.177	0.669
1.0	0.992	10.00	0.246	0.216	-0.177	0.669
1.1	0.992	12.60	0.246	0.216	-0.177	0.669
1.2	0.992	15.80	0.246	0.216	-0.177	0.669
1.3	0.992	20.00	0.246	0.216	-0.177	0.669
1.4	0.991	25.10	0.246	0.216	-0.177	0.669
1.5	0.991	31.60	0.246	0.216	-0.177	0.669
1.6	0.989	39.80	0.246	0.216	-0.178	0.670
1.7	0.989	50.10	0.246	0.216	-0.178	0.670
1.8	0.988	63.10	0.246	0.216	-0.178	0.670
1.9	0.988	79.40	0.246	0.216	-0.178	0.670
2.0	0.986	100.00	0.246	0.217	-0.178	0.670
2.1	0.986	126.00	0.246	0.217	-0.178	0.670
2.2	0.985	158.00	0.246	0.217	-0.179	0.671
2.3	0.985	200.00	0.246	0.217	-0.179	0.671
2.4	0.985	251.00	0.246	0.217	-0.179	0.671
2.5	0.985	316.00	0.246	0.217	-0.179	0.671
2.6	0.985	398.00	0.246	0.217	-0.179	0.671
2.7	0.984	501.00	0.252	0.213	-0.165	0.670
2.8	0.970	631.00	0.252	0.215	-0.168	0.673
2.9	0.959	794.00	0.252	0.216	-0.171	0.675
3.0	0.947	1000.00	0.252	0.217	-0.173	0.678
3.1	0.912	1260.00	0.252	0.219	-0.177	0.682
3.2	0.860	1580.00	0.252	0.224	-0.186	0.691
3.3	0.804	2000.00	0.252	0.226	-0.190	0.695
3.4	0.706	2510.00	0.252	0.233	-0.203	0.708
3.5	0.582	3160.00	0.252	0.276	-0.288	0.793
3.6	0.428	3980.00	0.252	0.303	-0.340	0.845
3.7	0.385	5010.00	0.252	0.294	-0.324	0.829
3.8	0.272	6310.00	0.252	0.321	-0.378	0.883
3.9	0.149	7940.00	0.252	0.520	-0.767	1.270
4.0	0.085	10000.00	0.252	0.832	-1.380	1.880

IgG_gp70ClAEV1V2

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00362	0.000724	0.00220	0.00504
0.1	0.997	1.26	0.00362	0.000774	0.00211	0.00514
0.2	0.997	1.58	0.00362	0.000774	0.00211	0.00514
0.3	0.997	2.00	0.00362	0.000774	0.00211	0.00514
0.4	0.995	2.51	0.00362	0.000775	0.00210	0.00514
0.5	0.994	3.16	0.00362	0.000776	0.00210	0.00514
0.6	0.992	3.98	0.00362	0.000776	0.00210	0.00514
0.7	0.992	5.01	0.00362	0.000776	0.00210	0.00514
0.8	0.992	6.31	0.00362	0.000776	0.00210	0.00514
0.9	0.992	7.94	0.00362	0.000776	0.00210	0.00514
1.0	0.992	10.00	0.00362	0.000776	0.00210	0.00514
1.1	0.992	12.60	0.00362	0.000776	0.00210	0.00514
1.2	0.992	15.80	0.00362	0.000776	0.00210	0.00514
1.3	0.992	20.00	0.00349	0.000759	0.00200	0.00498
1.4	0.992	25.10	0.00349	0.000759	0.00200	0.00498
1.5	0.992	31.60	0.00349	0.000759	0.00200	0.00498
1.6	0.992	39.80	0.00349	0.000759	0.00200	0.00498
1.7	0.991	50.10	0.00349	0.000760	0.00200	0.00498
1.8	0.991	63.10	0.00349	0.000760	0.00200	0.00498
1.9	0.991	79.40	0.00349	0.000760	0.00200	0.00498
2.0	0.991	100.00	0.00349	0.000760	0.00200	0.00498
2.1	0.991	126.00	0.00349	0.000760	0.00200	0.00498
2.2	0.991	158.00	0.00349	0.000760	0.00200	0.00498
2.3	0.991	200.00	0.00349	0.000760	0.00200	0.00498
2.4	0.989	251.00	0.00349	0.000761	0.00200	0.00498
2.5	0.988	316.00	0.00349	0.000762	0.00200	0.00498
2.6	0.986	398.00	0.00349	0.000763	0.00200	0.00499
2.7	0.986	501.00	0.00349	0.000763	0.00200	0.00499
2.8	0.986	631.00	0.00349	0.000763	0.00200	0.00499
2.9	0.981	794.00	0.00349	0.000765	0.00199	0.00499
3.0	0.981	1000.00	0.00349	0.000765	0.00199	0.00499
3.1	0.981	1260.00	0.00342	0.000748	0.00196	0.00489
3.2	0.977	1580.00	0.00342	0.000753	0.00195	0.00490
3.3	0.972	2000.00	0.00342	0.000755	0.00194	0.00490
3.4	0.960	2510.00	0.00342	0.000766	0.00192	0.00493
3.5	0.960	3160.00	0.00342	0.000766	0.00192	0.00493
3.6	0.956	3980.00	0.00342	0.000769	0.00192	0.00493
3.7	0.956	5010.00	0.00318	0.000732	0.00174	0.00461
3.8	0.945	6310.00	0.00318	0.000738	0.00173	0.00463
3.9	0.923	7940.00	0.00300	0.000718	0.00159	0.00441
4.0	0.914	10000.00	0.00300	0.000724	0.00158	0.00442
4.1	0.868	12600.00	0.00300	0.000748	0.00154	0.00447
4.2	0.807	15800.00	0.00300	0.000788	0.00146	0.00455
4.3	0.729	20000.00	0.00294	0.000805	0.00136	0.00452
4.4	0.401	25100.00	0.00294	0.001230	0.00054	0.00534

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	0.00210	0.00513
0.1	1.26	0.997	0.00362	0.000774	0.00210	0.00514
0.2	1.58	0.997	0.00362	0.000774	0.00210	0.00514
0.3	2.00	0.997	0.00362	0.000774	0.00210	0.00514
0.4	2.51	0.995	0.00362	0.000775	0.00210	0.00514
0.5	3.16	0.994	0.00362	0.000776	0.00210	0.00514
0.6	3.98	0.992	0.00363	0.000776	0.00211	0.00515
0.7	5.01	0.992	0.00363	0.000776	0.00211	0.00515
0.8	6.31	0.992	0.00363	0.000776	0.00211	0.00515
0.9	7.94	0.992	0.00363	0.000776	0.00211	0.00515
1.0	10.00	0.992	0.00363	0.000776	0.00211	0.00515
1.1	12.60	0.992	0.00363	0.000776	0.00211	0.00515
1.2	15.80	0.992	0.00363	0.000776	0.00211	0.00515
1.3	20.00	0.992	0.00348	0.000759	0.00199	0.00497
1.4	25.10	0.992	0.00348	0.000759	0.00199	0.00497
1.5	31.60	0.992	0.00348	0.000759	0.00199	0.00497
1.6	39.80	0.992	0.00348	0.000759	0.00199	0.00497
1.7	50.10	0.991	0.00348	0.000760	0.00200	0.00497
1.8	63.10	0.991	0.00348	0.000760	0.00200	0.00497
1.9	79.40	0.991	0.00348	0.000760	0.00200	0.00497
2.0	100.00	0.991	0.00348	0.000760	0.00200	0.00497
2.1	126.00	0.991	0.00348	0.000760	0.00200	0.00497
2.2	158.00	0.991	0.00348	0.000760	0.00200	0.00497
2.3	200.00	0.991	0.00348	0.000760	0.00200	0.00497
2.4	251.00	0.989	0.00349	0.000761	0.00200	0.00499
2.5	316.00	0.988	0.00350	0.000762	0.00200	0.00499
2.6	398.00	0.986	0.00350	0.000763	0.00201	0.00500
2.7	501.00	0.986	0.00350	0.000763	0.00201	0.00500
2.8	631.00	0.986	0.00350	0.000763	0.00201	0.00500
2.9	794.00	0.981	0.00351	0.000765	0.00201	0.00501
3.0	1000.00	0.981	0.00351	0.000765	0.00201	0.00501
3.1	1260.00	0.981	0.00337	0.000748	0.00190	0.00483
3.2	1580.00	0.977	0.00339	0.000753	0.00192	0.00487
3.3	2000.00	0.972	0.00341	0.000755	0.00193	0.00489
3.4	2510.00	0.960	0.00345	0.000766	0.00195	0.00496
3.5	3160.00	0.960	0.00345	0.000766	0.00195	0.00496
3.6	3980.00	0.956	0.00347	0.000769	0.00196	0.00497
3.7	5010.00	0.956	0.00317	0.000732	0.00173	0.00460
3.8	6310.00	0.945	0.00319	0.000738	0.00175	0.00464
3.9	7940.00	0.923	0.00296	0.000718	0.00156	0.00437
4.0	10000.00	0.914	0.00298	0.000724	0.00157	0.00440
4.1	12600.00	0.868	0.00300	0.000748	0.00153	0.00446
4.2	15800.00	0.807	0.00306	0.000788	0.00152	0.00461
4.3	20000.00	0.729	0.00294	0.000805	0.00136	0.00452
4.4	25100.00	0.401	0.00345	0.001230	0.00105	0.00585

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.217	0.214	-0.2020	0.636
0.1	0.997	1.26	0.217	0.222	-0.2180	0.652
0.2	0.997	1.58	0.217	0.222	-0.2180	0.652
0.3	0.997	2.00	0.217	0.222	-0.2180	0.652
0.4	0.995	2.51	0.217	0.222	-0.2180	0.652
0.5	0.994	3.16	0.217	0.222	-0.2180	0.652
0.6	0.992	3.98	0.217	0.222	-0.2190	0.653
0.7	0.992	5.01	0.217	0.222	-0.2190	0.653
0.8	0.992	6.31	0.217	0.222	-0.2190	0.653
0.9	0.992	7.94	0.217	0.222	-0.2190	0.653
1.0	0.992	10.00	0.217	0.222	-0.2190	0.653
1.1	0.992	12.60	0.217	0.222	-0.2190	0.653
1.2	0.992	15.80	0.217	0.222	-0.2190	0.653
1.3	0.992	20.00	0.246	0.216	-0.1780	0.669
1.4	0.992	25.10	0.246	0.216	-0.1780	0.669
1.5	0.992	31.60	0.246	0.216	-0.1780	0.669
1.6	0.992	39.80	0.246	0.216	-0.1780	0.669
1.7	0.991	50.10	0.246	0.216	-0.1780	0.669
1.8	0.991	63.10	0.246	0.216	-0.1780	0.669
1.9	0.991	79.40	0.246	0.216	-0.1780	0.669
2.0	0.991	100.00	0.246	0.216	-0.1780	0.669
2.1	0.991	126.00	0.246	0.216	-0.1780	0.669
2.2	0.991	158.00	0.246	0.216	-0.1780	0.669
2.3	0.991	200.00	0.246	0.216	-0.1780	0.669
2.4	0.989	251.00	0.246	0.216	-0.1780	0.670
2.5	0.988	316.00	0.246	0.216	-0.1790	0.670
2.6	0.986	398.00	0.246	0.217	-0.1790	0.670
2.7	0.986	501.00	0.246	0.217	-0.1790	0.670
2.8	0.986	631.00	0.246	0.217	-0.1790	0.670
2.9	0.981	794.00	0.246	0.217	-0.1800	0.671
3.0	0.981	1000.00	0.246	0.217	-0.1800	0.671
3.1	0.981	1260.00	0.260	0.212	-0.1560	0.676
3.2	0.977	1580.00	0.260	0.213	-0.1580	0.678
3.3	0.972	2000.00	0.260	0.214	-0.1590	0.679
3.4	0.960	2510.00	0.260	0.215	-0.1620	0.682
3.5	0.960	3160.00	0.260	0.215	-0.1620	0.682
3.6	0.956	3980.00	0.260	0.216	-0.1630	0.683
3.7	0.956	5010.00	0.313	0.203	-0.0857	0.712
3.8	0.945	6310.00	0.313	0.205	-0.0879	0.714
3.9	0.923	7940.00	0.351	0.197	-0.0340	0.737
4.0	0.914	10000.00	0.351	0.198	-0.0360	0.739
4.1	0.868	12600.00	0.351	0.202	-0.0440	0.747
4.2	0.807	15800.00	0.351	0.209	-0.0579	0.761
4.3	0.729	20000.00	0.364	0.210	-0.0482	0.777
4.4	0.401	25100.00	0.364	0.290	-0.2050	0.933

IgG_gp70V1V2A

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00361	0.000724	2.19e-03	0.00503
0.1	0.9920	1.26	0.00352	0.000759	2.03e-03	0.00501
0.2	0.9920	1.58	0.00352	0.000759	2.03e-03	0.00501
0.3	0.9920	2.00	0.00352	0.000759	2.03e-03	0.00501
0.4	0.9910	2.51	0.00352	0.000761	2.03e-03	0.00501
0.5	0.9890	3.16	0.00352	0.000761	2.03e-03	0.00501
0.6	0.9890	3.98	0.00352	0.000761	2.03e-03	0.00501
0.7	0.9880	5.01	0.00352	0.000762	2.02e-03	0.00501
0.8	0.9860	6.31	0.00352	0.000763	2.02e-03	0.00501
0.9	0.9820	7.94	0.00352	0.000765	2.02e-03	0.00502
1.0	0.9820	10.00	0.00352	0.000765	2.02e-03	0.00502
1.1	0.9820	12.60	0.00352	0.000765	2.02e-03	0.00502
1.2	0.9680	15.80	0.00352	0.000775	2.00e-03	0.00504
1.3	0.9680	20.00	0.00352	0.000775	2.00e-03	0.00504
1.4	0.9680	25.10	0.00352	0.000775	2.00e-03	0.00504
1.5	0.9680	31.60	0.00352	0.000775	2.00e-03	0.00504
1.6	0.9530	39.80	0.00347	0.000767	1.97e-03	0.00498
1.7	0.9480	50.10	0.00347	0.000774	1.96e-03	0.00499
1.8	0.9420	63.10	0.00338	0.000760	1.89e-03	0.00487
1.9	0.9290	79.40	0.00338	0.000772	1.87e-03	0.00489
2.0	0.9000	100.00	0.00332	0.000769	1.81e-03	0.00482
2.1	0.8790	126.00	0.00323	0.000768	1.73e-03	0.00474
2.2	0.8520	158.00	0.00286	0.000732	1.42e-03	0.00429
2.3	0.8390	200.00	0.00254	0.000689	1.19e-03	0.00389
2.4	0.8080	251.00	0.00246	0.000691	1.11e-03	0.00382
2.5	0.7580	316.00	0.00206	0.000648	7.92e-04	0.00333
2.6	0.7120	398.00	0.00206	0.000629	8.28e-04	0.00329
2.7	0.6310	501.00	0.00206	0.000675	7.37e-04	0.00338
2.8	0.5160	631.00	0.00206	0.000755	5.80e-04	0.00354
2.9	0.4650	794.00	0.00206	0.000850	3.95e-04	0.00373
3.0	0.4290	1000.00	0.00206	0.000831	4.31e-04	0.00369
3.1	0.3440	1260.00	0.00206	0.000961	1.76e-04	0.00395
3.2	0.2870	1580.00	0.00206	0.001100	-8.71e-05	0.00421
3.3	0.2160	2000.00	0.00206	0.001380	-6.51e-04	0.00477
3.4	0.1630	2510.00	0.00206	0.001870	-1.60e-03	0.00572
3.5	0.1300	3160.00	0.00206	0.002510	-2.86e-03	0.00698
3.6	0.0981	3980.00	0.00206	0.003960	-5.70e-03	0.00982

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00361	0.000724	0.002100	0.00513
0.1	1.26	0.9920	0.00348	0.000759	0.002000	0.00497
0.2	1.58	0.9920	0.00348	0.000759	0.002000	0.00497
0.3	2.00	0.9920	0.00348	0.000759	0.002000	0.00497
0.4	2.51	0.9910	0.00349	0.000761	0.002000	0.00498
0.5	3.16	0.9890	0.00350	0.000761	0.002000	0.00499
0.6	3.98	0.9890	0.00350	0.000761	0.002000	0.00499
0.7	5.01	0.9880	0.00350	0.000762	0.002010	0.00499
0.8	6.31	0.9860	0.00350	0.000763	0.002010	0.00500
0.9	7.94	0.9820	0.00352	0.000765	0.002020	0.00502
1.0	10.00	0.9820	0.00352	0.000765	0.002020	0.00502
1.1	12.60	0.9820	0.00352	0.000765	0.002020	0.00502
1.2	15.80	0.9680	0.00357	0.000775	0.002050	0.00509
1.3	20.00	0.9680	0.00357	0.000775	0.002050	0.00509
1.4	25.10	0.9680	0.00357	0.000775	0.002050	0.00509
1.5	31.60	0.9680	0.00357	0.000775	0.002050	0.00509
1.6	39.80	0.9530	0.00346	0.000767	0.001960	0.00496
1.7	50.10	0.9480	0.00349	0.000774	0.001970	0.00500
1.8	63.10	0.9420	0.00336	0.000760	0.001870	0.00484
1.9	79.40	0.9290	0.00341	0.000772	0.001890	0.00492
2.0	100.00	0.9000	0.00332	0.000769	0.001810	0.00482
2.1	126.00	0.8790	0.00323	0.000768	0.001730	0.00474
2.2	158.00	0.8520	0.00286	0.000732	0.001420	0.00429
2.3	200.00	0.8390	0.00254	0.000689	0.001190	0.00389
2.4	251.00	0.8080	0.00246	0.000691	0.001110	0.00382
2.5	316.00	0.7580	0.00205	0.000648	0.000785	0.00332
2.6	398.00	0.7120	0.00181	0.000629	0.000579	0.00305
2.7	501.00	0.6310	0.00182	0.000675	0.000502	0.00315
2.8	631.00	0.5160	0.00189	0.000755	0.000405	0.00337
2.9	794.00	0.4650	0.00212	0.000850	0.000454	0.00378
3.0	1000.00	0.4290	0.00190	0.000831	0.000275	0.00353
3.1	1260.00	0.3440	0.00175	0.000961	-0.000134	0.00363
3.2	1580.00	0.2870	0.00201	0.001100	-0.000142	0.00415
3.3	2000.00	0.2160	0.00259	0.001380	-0.000121	0.00530
3.4	2510.00	0.1630	0.00349	0.001870	-0.000174	0.00715
3.5	3160.00	0.1300	0.00463	0.002510	-0.000286	0.00955
3.6	3980.00	0.0981	0.00694	0.003960	-0.000818	0.01470

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.220	0.214	-0.199000	0.638
0.1	0.9920	1.26	0.240	0.217	-0.185000	0.664
0.2	0.9920	1.58	0.240	0.217	-0.185000	0.664
0.3	0.9920	2.00	0.240	0.217	-0.185000	0.664
0.4	0.9910	2.51	0.240	0.217	-0.185000	0.665
0.5	0.9890	3.16	0.240	0.217	-0.186000	0.665
0.6	0.9890	3.98	0.240	0.217	-0.186000	0.665
0.7	0.9880	5.01	0.240	0.217	-0.186000	0.666
0.8	0.9860	6.31	0.240	0.217	-0.186000	0.666
0.9	0.9820	7.94	0.240	0.218	-0.187000	0.666
1.0	0.9820	10.00	0.240	0.218	-0.187000	0.666
1.1	0.9820	12.60	0.240	0.218	-0.187000	0.666
1.2	0.9680	15.80	0.240	0.219	-0.190000	0.670
1.3	0.9680	20.00	0.240	0.219	-0.190000	0.670
1.4	0.9680	25.10	0.240	0.219	-0.190000	0.670
1.5	0.9680	31.60	0.240	0.219	-0.190000	0.670
1.6	0.9530	39.80	0.250	0.217	-0.175000	0.675
1.7	0.9480	50.10	0.250	0.218	-0.178000	0.677
1.8	0.9420	63.10	0.269	0.213	-0.149000	0.687
1.9	0.9290	79.40	0.269	0.215	-0.153000	0.691
2.0	0.9000	100.00	0.283	0.213	-0.135000	0.701
2.1	0.8790	126.00	0.301	0.211	-0.112000	0.714
2.2	0.8520	158.00	0.383	0.195	-0.000602	0.766
2.3	0.8390	200.00	0.451	0.181	0.097600	0.805
2.4	0.8080	251.00	0.468	0.179	0.117000	0.819
2.5	0.7580	316.00	0.555	0.163	0.236000	0.873
2.6	0.7120	398.00	0.555	0.159	0.243000	0.867
2.7	0.6310	501.00	0.555	0.168	0.226000	0.884
2.8	0.5160	631.00	0.555	0.183	0.196000	0.914
2.9	0.4650	794.00	0.555	0.202	0.160000	0.950
3.0	0.4290	1000.00	0.555	0.198	0.167000	0.943
3.1	0.3440	1260.00	0.555	0.224	0.116000	0.993
3.2	0.2870	1580.00	0.555	0.251	0.062900	1.050
3.3	0.2160	2000.00	0.555	0.310	-0.053400	1.160
3.4	0.1630	2510.00	0.555	0.412	-0.253000	1.360
3.5	0.1300	3160.00	0.555	0.549	-0.521000	1.630
3.6	0.0981	3980.00	0.555	0.859	-1.130000	2.240

IgG_gp70V1V2AP

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00361	0.000724	0.002190	0.00503
0.1	0.998	1.26	0.00348	0.000756	0.002000	0.00497
0.2	0.998	1.58	0.00348	0.000756	0.002000	0.00497
0.3	0.998	2.00	0.00348	0.000756	0.002000	0.00497
0.4	0.997	2.51	0.00348	0.000757	0.002000	0.00497
0.5	0.997	3.16	0.00348	0.000757	0.002000	0.00497
0.6	0.992	3.98	0.00348	0.000759	0.002000	0.00497
0.7	0.987	5.01	0.00348	0.000762	0.001990	0.00498
0.8	0.982	6.31	0.00348	0.000765	0.001980	0.00498
0.9	0.974	7.94	0.00342	0.000753	0.001940	0.00490
1.0	0.974	10.00	0.00342	0.000753	0.001940	0.00490
1.1	0.974	12.60	0.00342	0.000753	0.001940	0.00490
1.2	0.974	15.80	0.00342	0.000753	0.001940	0.00490
1.3	0.958	20.00	0.00342	0.000767	0.001920	0.00492
1.4	0.950	25.10	0.00342	0.000773	0.001900	0.00493
1.5	0.950	31.60	0.00334	0.000754	0.001860	0.00482
1.6	0.940	39.80	0.00334	0.000759	0.001850	0.00483
1.7	0.919	50.10	0.00312	0.000734	0.001680	0.00456
1.8	0.908	63.10	0.00312	0.000743	0.001660	0.00457
1.9	0.885	79.40	0.00294	0.000720	0.001530	0.00435
2.0	0.844	100.00	0.00294	0.000748	0.001480	0.00441
2.1	0.792	126.00	0.00271	0.000739	0.001270	0.00416
2.2	0.735	158.00	0.00258	0.000726	0.001150	0.00400
2.3	0.652	200.00	0.00258	0.000789	0.001030	0.00412
2.4	0.606	251.00	0.00258	0.000811	0.000986	0.00417
2.5	0.524	316.00	0.00258	0.000902	0.000808	0.00435
2.6	0.460	398.00	0.00258	0.001030	0.000558	0.00459
2.7	0.398	501.00	0.00258	0.001190	0.000241	0.00491
2.8	0.341	631.00	0.00258	0.001130	0.000366	0.00479
2.9	0.258	794.00	0.00258	0.001230	0.000166	0.00499
3.0	0.207	1000.00	0.00258	0.001660	-0.000673	0.00583
3.1	0.175	1260.00	0.00258	0.001250	0.000119	0.00503
3.2	0.124	1580.00	0.00258	0.002010	-0.001360	0.00651

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	0.002100	0.00513
0.1	1.26	0.998	0.00347	0.000756	0.001990	0.00495
0.2	1.58	0.998	0.00347	0.000756	0.001990	0.00495
0.3	2.00	0.998	0.00347	0.000756	0.001990	0.00495
0.4	2.51	0.997	0.00347	0.000757	0.001990	0.00496
0.5	3.16	0.997	0.00347	0.000757	0.001990	0.00496
0.6	3.98	0.992	0.00348	0.000759	0.001990	0.00497
0.7	5.01	0.987	0.00350	0.000762	0.002010	0.00500
0.8	6.31	0.982	0.00352	0.000765	0.002020	0.00501
0.9	7.94	0.974	0.00339	0.000753	0.001920	0.00487
1.0	10.00	0.974	0.00339	0.000753	0.001920	0.00487
1.1	12.60	0.974	0.00339	0.000753	0.001920	0.00487
1.2	15.80	0.974	0.00339	0.000753	0.001920	0.00487
1.3	20.00	0.958	0.00346	0.000767	0.001960	0.00496
1.4	25.10	0.950	0.00348	0.000773	0.001970	0.00500
1.5	31.60	0.950	0.00333	0.000754	0.001850	0.00481
1.6	39.80	0.940	0.00335	0.000759	0.001860	0.00484
1.7	50.10	0.919	0.00310	0.000734	0.001660	0.00454
1.8	63.10	0.908	0.00313	0.000743	0.001680	0.00459
1.9	79.40	0.885	0.00289	0.000720	0.001480	0.00430
2.0	100.00	0.844	0.00300	0.000748	0.001530	0.00446
2.1	126.00	0.792	0.00271	0.000739	0.001270	0.00416
2.2	158.00	0.735	0.00249	0.000726	0.001060	0.00391
2.3	200.00	0.652	0.00259	0.000789	0.001050	0.00414
2.4	251.00	0.606	0.00255	0.000811	0.000963	0.00414
2.5	316.00	0.524	0.00269	0.000902	0.000921	0.00446
2.6	398.00	0.460	0.00290	0.001030	0.000886	0.00492
2.7	501.00	0.398	0.00333	0.001190	0.000996	0.00567
2.8	631.00	0.341	0.00278	0.001130	0.000568	0.00499
2.9	794.00	0.258	0.00227	0.001230	-0.000137	0.00468
3.0	1000.00	0.207	0.00296	0.001660	-0.000289	0.00621
3.1	1260.00	0.175	0.00207	0.001250	-0.000392	0.00452
3.2	1580.00	0.124	0.00325	0.002010	-0.000692	0.00718

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.220	0.214	-0.1990	0.638
0.1	0.998	1.26	0.247	0.215	-0.1750	0.669
0.2	0.998	1.58	0.247	0.215	-0.1750	0.669
0.3	0.998	2.00	0.247	0.215	-0.1750	0.669
0.4	0.997	2.51	0.247	0.215	-0.1750	0.670
0.5	0.997	3.16	0.247	0.215	-0.1750	0.670
0.6	0.992	3.98	0.247	0.216	-0.1750	0.670
0.7	0.987	5.01	0.247	0.216	-0.1770	0.671
0.8	0.982	6.31	0.247	0.217	-0.1770	0.672
0.9	0.974	7.94	0.261	0.213	-0.1570	0.679
1.0	0.974	10.00	0.261	0.213	-0.1570	0.679
1.1	0.974	12.60	0.261	0.213	-0.1570	0.679
1.2	0.974	15.80	0.261	0.213	-0.1570	0.679
1.3	0.958	20.00	0.261	0.215	-0.1610	0.683
1.4	0.950	25.10	0.261	0.216	-0.1630	0.685
1.5	0.950	31.60	0.278	0.211	-0.1360	0.692
1.6	0.940	39.80	0.278	0.212	-0.1380	0.694
1.7	0.919	50.10	0.326	0.202	-0.0700	0.723
1.8	0.908	63.10	0.326	0.204	-0.0729	0.726
1.9	0.885	79.40	0.364	0.196	-0.0191	0.747
2.0	0.844	100.00	0.364	0.200	-0.0286	0.757
2.1	0.792	126.00	0.414	0.193	0.0345	0.793
2.2	0.735	158.00	0.443	0.188	0.0747	0.812
2.3	0.652	200.00	0.443	0.200	0.0521	0.834
2.4	0.606	251.00	0.443	0.204	0.0440	0.842
2.5	0.524	316.00	0.443	0.221	0.0104	0.876
2.6	0.460	398.00	0.443	0.245	-0.0379	0.924
2.7	0.398	501.00	0.443	0.278	-0.1010	0.987
2.8	0.341	631.00	0.443	0.265	-0.0759	0.962
2.9	0.258	794.00	0.443	0.285	-0.1160	1.000
3.0	0.207	1000.00	0.443	0.373	-0.2880	1.170
3.1	0.175	1260.00	0.443	0.290	-0.1250	1.010
3.2	0.124	1580.00	0.443	0.446	-0.4320	1.320

IgG_gp70V1V2C

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00361	0.000724	2.19e-03	0.00503
0.1	0.988	1.26	0.00354	0.000766	2.03e-03	0.00504
0.2	0.988	1.58	0.00354	0.000766	2.03e-03	0.00504
0.3	0.988	2.00	0.00354	0.000766	2.03e-03	0.00504
0.4	0.987	2.51	0.00354	0.000767	2.03e-03	0.00504
0.5	0.985	3.16	0.00354	0.000767	2.03e-03	0.00504
0.6	0.985	3.98	0.00354	0.000767	2.03e-03	0.00504
0.7	0.984	5.01	0.00354	0.000770	2.03e-03	0.00505
0.8	0.984	6.31	0.00354	0.000770	2.03e-03	0.00505
0.9	0.978	7.94	0.00354	0.000771	2.02e-03	0.00505
1.0	0.969	10.00	0.00354	0.000778	2.01e-03	0.00506
1.1	0.962	12.60	0.00354	0.000783	2.00e-03	0.00507
1.2	0.956	15.80	0.00349	0.000768	1.98e-03	0.00499
1.3	0.946	20.00	0.00349	0.000779	1.96e-03	0.00501
1.4	0.936	25.10	0.00323	0.000748	1.76e-03	0.00470
1.5	0.927	31.60	0.00298	0.000716	1.58e-03	0.00438
1.6	0.915	39.80	0.00298	0.000722	1.57e-03	0.00440
1.7	0.899	50.10	0.00298	0.000731	1.55e-03	0.00441
1.8	0.881	63.10	0.00276	0.000706	1.38e-03	0.00415
1.9	0.852	79.40	0.00266	0.000700	1.29e-03	0.00403
2.0	0.830	100.00	0.00260	0.000693	1.24e-03	0.00395
2.1	0.796	126.00	0.00260	0.000721	1.18e-03	0.00401
2.2	0.738	158.00	0.00244	0.000715	1.04e-03	0.00384
2.3	0.678	200.00	0.00243	0.000743	9.80e-04	0.00389
2.4	0.624	251.00	0.00243	0.000812	8.43e-04	0.00403
2.5	0.575	316.00	0.00192	0.000707	5.29e-04	0.00330
2.6	0.533	398.00	0.00179	0.000704	4.12e-04	0.00317
2.7	0.449	501.00	0.00179	0.000739	3.42e-04	0.00324
2.8	0.378	631.00	0.00179	0.000877	7.32e-05	0.00351
2.9	0.304	794.00	0.00179	0.000966	-1.02e-04	0.00368
3.0	0.252	1000.00	0.00179	0.001130	-4.22e-04	0.00400

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	2.10e-03	0.00513
0.1	1.26	0.988	0.00352	0.000766	2.01e-03	0.00502
0.2	1.58	0.988	0.00352	0.000766	2.01e-03	0.00502
0.3	2.00	0.988	0.00352	0.000766	2.01e-03	0.00502
0.4	2.51	0.987	0.00352	0.000767	2.02e-03	0.00502
0.5	3.16	0.985	0.00352	0.000767	2.02e-03	0.00503
0.6	3.98	0.985	0.00352	0.000767	2.02e-03	0.00503
0.7	5.01	0.984	0.00353	0.000770	2.02e-03	0.00504
0.8	6.31	0.984	0.00353	0.000770	2.02e-03	0.00504
0.9	7.94	0.978	0.00355	0.000771	2.04e-03	0.00506
1.0	10.00	0.969	0.00358	0.000778	2.05e-03	0.00510
1.1	12.60	0.962	0.00360	0.000783	2.06e-03	0.00513
1.2	15.80	0.956	0.00346	0.000768	1.96e-03	0.00497
1.3	20.00	0.946	0.00351	0.000779	1.98e-03	0.00504
1.4	25.10	0.936	0.00323	0.000748	1.76e-03	0.00470
1.5	31.60	0.927	0.00295	0.000716	1.55e-03	0.00436
1.6	39.80	0.915	0.00298	0.000722	1.56e-03	0.00439
1.7	50.10	0.899	0.00301	0.000731	1.58e-03	0.00444
1.8	63.10	0.881	0.00276	0.000706	1.38e-03	0.00415
1.9	79.40	0.852	0.00266	0.000700	1.29e-03	0.00403
2.0	100.00	0.830	0.00255	0.000693	1.19e-03	0.00391
2.1	126.00	0.796	0.00264	0.000721	1.23e-03	0.00406
2.2	158.00	0.738	0.00244	0.000715	1.04e-03	0.00384
2.3	200.00	0.678	0.00233	0.000743	8.74e-04	0.00378
2.4	251.00	0.624	0.00254	0.000812	9.53e-04	0.00414
2.5	316.00	0.575	0.00192	0.000707	5.29e-04	0.00330
2.6	398.00	0.533	0.00178	0.000704	4.04e-04	0.00316
2.7	501.00	0.449	0.00159	0.000739	1.43e-04	0.00304
2.8	631.00	0.378	0.00187	0.000877	1.57e-04	0.00359
2.9	794.00	0.304	0.00183	0.000966	-6.63e-05	0.00372
3.0	1000.00	0.252	0.00188	0.001130	-3.34e-04	0.00409

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.220	0.214	-0.1990	0.638
0.1	0.988	1.26	0.236	0.218	-0.1920	0.664
0.2	0.988	1.58	0.236	0.218	-0.1920	0.664
0.3	0.988	2.00	0.236	0.218	-0.1920	0.664
0.4	0.987	2.51	0.236	0.218	-0.1920	0.664
0.5	0.985	3.16	0.236	0.219	-0.1920	0.664
0.6	0.985	3.98	0.236	0.219	-0.1920	0.664
0.7	0.984	5.01	0.236	0.219	-0.1930	0.665
0.8	0.984	6.31	0.236	0.219	-0.1930	0.665
0.9	0.978	7.94	0.236	0.219	-0.1940	0.665
1.0	0.969	10.00	0.236	0.220	-0.1960	0.667
1.1	0.962	12.60	0.236	0.221	-0.1970	0.669
1.2	0.956	15.80	0.247	0.217	-0.1790	0.673
1.3	0.946	20.00	0.247	0.219	-0.1830	0.676
1.4	0.936	25.10	0.302	0.207	-0.1040	0.708
1.5	0.927	31.60	0.356	0.196	-0.0278	0.740
1.6	0.915	39.80	0.356	0.197	-0.0299	0.742
1.7	0.899	50.10	0.356	0.198	-0.0328	0.745
1.8	0.881	63.10	0.403	0.189	0.0333	0.773
1.9	0.852	79.40	0.426	0.185	0.0623	0.789
2.0	0.830	100.00	0.439	0.183	0.0813	0.797
2.1	0.796	126.00	0.439	0.188	0.0715	0.807
2.2	0.738	158.00	0.473	0.183	0.1140	0.832
2.3	0.678	200.00	0.474	0.188	0.1050	0.842
2.4	0.624	251.00	0.474	0.201	0.0799	0.868
2.5	0.575	316.00	0.586	0.171	0.2510	0.922
2.6	0.533	398.00	0.613	0.168	0.2830	0.943
2.7	0.449	501.00	0.613	0.175	0.2690	0.956
2.8	0.378	631.00	0.613	0.203	0.2160	1.010
2.9	0.304	794.00	0.613	0.221	0.1800	1.050
3.0	0.252	1000.00	0.613	0.254	0.1140	1.110

IgG_gp70BCaseA2V1V2169K

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00361	0.000724	2.19e-03	0.00503
0.1	0.998	1.26	0.00349	0.000756	2.00e-03	0.00497
0.2	0.998	1.58	0.00349	0.000756	2.00e-03	0.00497
0.3	0.998	2.00	0.00349	0.000756	2.00e-03	0.00497
0.4	0.997	2.51	0.00349	0.000757	2.00e-03	0.00497
0.5	0.995	3.16	0.00349	0.000758	2.00e-03	0.00497
0.6	0.995	3.98	0.00349	0.000758	2.00e-03	0.00497
0.7	0.994	5.01	0.00349	0.000758	2.00e-03	0.00497
0.8	0.994	6.31	0.00349	0.000758	2.00e-03	0.00497
0.9	0.991	7.94	0.00349	0.000760	2.00e-03	0.00497
1.0	0.989	10.00	0.00349	0.000760	1.99e-03	0.00498
1.1	0.989	12.60	0.00349	0.000760	1.99e-03	0.00498
1.2	0.989	15.80	0.00349	0.000760	1.99e-03	0.00498
1.3	0.982	20.00	0.00349	0.000766	1.98e-03	0.00499
1.4	0.975	25.10	0.00349	0.000769	1.98e-03	0.00499
1.5	0.971	31.60	0.00342	0.000755	1.94e-03	0.00489
1.6	0.967	39.80	0.00342	0.000758	1.93e-03	0.00490
1.7	0.961	50.10	0.00342	0.000763	1.92e-03	0.00491
1.8	0.957	63.10	0.00330	0.000747	1.83e-03	0.00476
1.9	0.941	79.40	0.00321	0.000742	1.75e-03	0.00466
2.0	0.941	100.00	0.00305	0.000722	1.64e-03	0.00447
2.1	0.937	126.00	0.00292	0.000708	1.53e-03	0.00431
2.2	0.920	158.00	0.00282	0.000701	1.44e-03	0.00419
2.3	0.885	200.00	0.00276	0.000699	1.39e-03	0.00413
2.4	0.864	251.00	0.00276	0.000716	1.36e-03	0.00417
2.5	0.827	316.00	0.00256	0.000696	1.19e-03	0.00392
2.6	0.781	398.00	0.00254	0.000717	1.13e-03	0.00394
2.7	0.723	501.00	0.00235	0.000715	9.51e-04	0.00375
2.8	0.675	631.00	0.00217	0.000683	8.27e-04	0.00350
2.9	0.615	794.00	0.00217	0.000758	6.79e-04	0.00365
3.0	0.539	1000.00	0.00217	0.000822	5.55e-04	0.00378
3.1	0.501	1260.00	0.00217	0.000869	4.62e-04	0.00387
3.2	0.399	1580.00	0.00217	0.001110	-1.56e-05	0.00435
3.3	0.337	2000.00	0.00217	0.001260	-3.13e-04	0.00464
3.4	0.263	2510.00	0.00217	0.001400	-5.70e-04	0.00490
3.5	0.207	3160.00	0.00217	0.001990	-1.74e-03	0.00607

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	2.10e-03	0.00513
0.1	1.26	0.998	0.00347	0.000756	1.99e-03	0.00495
0.2	1.58	0.998	0.00347	0.000756	1.99e-03	0.00495
0.3	2.00	0.998	0.00347	0.000756	1.99e-03	0.00495
0.4	2.51	0.997	0.00347	0.000757	1.99e-03	0.00496
0.5	3.16	0.995	0.00348	0.000758	1.99e-03	0.00496
0.6	3.98	0.995	0.00348	0.000758	1.99e-03	0.00496
0.7	5.01	0.994	0.00348	0.000758	1.99e-03	0.00497
0.8	6.31	0.994	0.00348	0.000758	1.99e-03	0.00497
0.9	7.94	0.991	0.00348	0.000760	2.00e-03	0.00497
1.0	10.00	0.989	0.00349	0.000760	2.00e-03	0.00498
1.1	12.60	0.989	0.00349	0.000760	2.00e-03	0.00498
1.2	15.80	0.989	0.00349	0.000760	2.00e-03	0.00498
1.3	20.00	0.982	0.00351	0.000766	2.01e-03	0.00501
1.4	25.10	0.975	0.00352	0.000769	2.02e-03	0.00503
1.5	31.60	0.971	0.00340	0.000755	1.92e-03	0.00488
1.6	39.80	0.967	0.00341	0.000758	1.93e-03	0.00490
1.7	50.10	0.961	0.00344	0.000763	1.94e-03	0.00493
1.8	63.10	0.957	0.00330	0.000747	1.83e-03	0.00476
1.9	79.40	0.941	0.00321	0.000742	1.75e-03	0.00466
2.0	100.00	0.941	0.00305	0.000722	1.64e-03	0.00447
2.1	126.00	0.937	0.00292	0.000708	1.53e-03	0.00431
2.2	158.00	0.920	0.00282	0.000701	1.44e-03	0.00419
2.3	200.00	0.885	0.00273	0.000699	1.36e-03	0.00410
2.4	251.00	0.864	0.00280	0.000716	1.39e-03	0.00420
2.5	316.00	0.827	0.00256	0.000696	1.19e-03	0.00392
2.6	398.00	0.781	0.00254	0.000717	1.13e-03	0.00394
2.7	501.00	0.723	0.00235	0.000715	9.51e-04	0.00375
2.8	631.00	0.675	0.00206	0.000683	7.17e-04	0.00339
2.9	794.00	0.615	0.00228	0.000758	7.91e-04	0.00376
3.0	1000.00	0.539	0.00233	0.000822	7.20e-04	0.00394
3.1	1260.00	0.501	0.00231	0.000869	6.06e-04	0.00401
3.2	1580.00	0.399	0.00268	0.001110	5.03e-04	0.00486
3.3	2000.00	0.337	0.00275	0.001260	2.71e-04	0.00523
3.4	2510.00	0.263	0.00281	0.001400	7.51e-05	0.00554
3.5	3160.00	0.207	0.00350	0.001990	-4.06e-04	0.00741

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.220	0.214	-0.19900	0.638
0.1	0.998	1.26	0.247	0.215	-0.17500	0.669
0.2	0.998	1.58	0.247	0.215	-0.17500	0.669
0.3	0.998	2.00	0.247	0.215	-0.17500	0.669
0.4	0.997	2.51	0.247	0.215	-0.17500	0.669
0.5	0.995	3.16	0.247	0.216	-0.17600	0.669
0.6	0.995	3.98	0.247	0.216	-0.17600	0.669
0.7	0.994	5.01	0.247	0.216	-0.17600	0.670
0.8	0.994	6.31	0.247	0.216	-0.17600	0.670
0.9	0.991	7.94	0.247	0.216	-0.17600	0.670
1.0	0.989	10.00	0.247	0.216	-0.17700	0.670
1.1	0.989	12.60	0.247	0.216	-0.17700	0.670
1.2	0.989	15.80	0.247	0.216	-0.17700	0.670
1.3	0.982	20.00	0.247	0.217	-0.17800	0.672
1.4	0.975	25.10	0.247	0.217	-0.17900	0.673
1.5	0.971	31.60	0.262	0.213	-0.15600	0.680
1.6	0.967	39.80	0.262	0.214	-0.15700	0.681
1.7	0.961	50.10	0.262	0.215	-0.15900	0.683
1.8	0.957	63.10	0.287	0.209	-0.12200	0.697
1.9	0.941	79.40	0.307	0.206	-0.09610	0.711
2.0	0.941	100.00	0.341	0.199	-0.04860	0.730
2.1	0.937	126.00	0.369	0.193	-0.00972	0.747
2.2	0.920	158.00	0.391	0.189	0.02070	0.762
2.3	0.885	200.00	0.403	0.188	0.03480	0.770
2.4	0.864	251.00	0.403	0.191	0.02910	0.776
2.5	0.827	316.00	0.448	0.182	0.09080	0.805
2.6	0.781	398.00	0.452	0.186	0.08820	0.816
2.7	0.723	501.00	0.492	0.181	0.13600	0.847
2.8	0.675	631.00	0.532	0.171	0.19600	0.868
2.9	0.615	794.00	0.532	0.186	0.16800	0.896
3.0	0.539	1000.00	0.532	0.198	0.14400	0.920
3.1	0.501	1260.00	0.532	0.207	0.12600	0.938
3.2	0.399	1580.00	0.532	0.256	0.03090	1.030
3.3	0.337	2000.00	0.532	0.287	-0.03010	1.090
3.4	0.263	2510.00	0.532	0.314	-0.08310	1.150
3.5	0.207	3160.00	0.532	0.440	-0.33000	1.390

IgG_gp70BCaseA2V1V2mut3

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00362	0.000724	0.002200	0.00504
0.1	0.997	1.26	0.00362	0.000774	0.002100	0.00514
0.2	0.997	1.58	0.00362	0.000774	0.002100	0.00514
0.3	0.997	2.00	0.00362	0.000774	0.002100	0.00514
0.4	0.997	2.51	0.00362	0.000774	0.002100	0.00514
0.5	0.997	3.16	0.00362	0.000774	0.002100	0.00514
0.6	0.995	3.98	0.00362	0.000775	0.002100	0.00514
0.7	0.994	5.01	0.00362	0.000776	0.002100	0.00514
0.8	0.994	6.31	0.00362	0.000776	0.002100	0.00514
0.9	0.992	7.94	0.00362	0.000776	0.002100	0.00514
1.0	0.992	10.00	0.00362	0.000776	0.002100	0.00514
1.1	0.992	12.60	0.00362	0.000776	0.002100	0.00514
1.2	0.992	15.80	0.00362	0.000776	0.002100	0.00514
1.3	0.992	20.00	0.00349	0.000759	0.002000	0.00498
1.4	0.992	25.10	0.00349	0.000759	0.002000	0.00498
1.5	0.992	31.60	0.00349	0.000759	0.002000	0.00498
1.6	0.991	39.80	0.00349	0.000760	0.002000	0.00498
1.7	0.991	50.10	0.00349	0.000760	0.002000	0.00498
1.8	0.991	63.10	0.00349	0.000760	0.002000	0.00498
1.9	0.991	79.40	0.00349	0.000760	0.002000	0.00498
2.0	0.991	100.00	0.00349	0.000760	0.002000	0.00498
2.1	0.991	126.00	0.00349	0.000760	0.002000	0.00498
2.2	0.991	158.00	0.00349	0.000760	0.002000	0.00498
2.3	0.989	200.00	0.00349	0.000761	0.002000	0.00498
2.4	0.986	251.00	0.00349	0.000763	0.002000	0.00499
2.5	0.986	316.00	0.00349	0.000763	0.002000	0.00499
2.6	0.986	398.00	0.00349	0.000763	0.002000	0.00499
2.7	0.986	501.00	0.00349	0.000763	0.002000	0.00499
2.8	0.981	631.00	0.00349	0.000765	0.001990	0.00499
2.9	0.981	794.00	0.00349	0.000765	0.001990	0.00499
3.0	0.981	1000.00	0.00342	0.000748	0.001950	0.00488
3.1	0.977	1260.00	0.00342	0.000753	0.001940	0.00489
3.2	0.972	1580.00	0.00342	0.000755	0.001940	0.00490
3.3	0.960	2000.00	0.00342	0.000766	0.001920	0.00492
3.4	0.956	2510.00	0.00342	0.000769	0.001910	0.00492
3.5	0.956	3160.00	0.00331	0.000750	0.001840	0.00478
3.6	0.950	3980.00	0.00318	0.000735	0.001740	0.00462
3.7	0.931	5010.00	0.00300	0.000711	0.001600	0.00439
3.8	0.914	6310.00	0.00300	0.000723	0.001580	0.00441
3.9	0.905	7940.00	0.00300	0.000733	0.001560	0.00443
4.0	0.829	10000.00	0.00300	0.000761	0.001500	0.00449
4.1	0.751	12600.00	0.00300	0.000817	0.001390	0.00460
4.2	0.683	15800.00	0.00298	0.000813	0.001390	0.00457
4.3	0.558	20000.00	0.00298	0.000986	0.001050	0.00491
4.4	0.314	25100.00	0.00298	0.001620	-0.000189	0.00615

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	0.002100	0.00513
0.1	1.26	0.997	0.00362	0.000774	0.002100	0.00514
0.2	1.58	0.997	0.00362	0.000774	0.002100	0.00514
0.3	2.00	0.997	0.00362	0.000774	0.002100	0.00514
0.4	2.51	0.997	0.00362	0.000774	0.002100	0.00514
0.5	3.16	0.997	0.00362	0.000774	0.002100	0.00514
0.6	3.98	0.995	0.00362	0.000775	0.002100	0.00514
0.7	5.01	0.994	0.00362	0.000776	0.002100	0.00514
0.8	6.31	0.994	0.00362	0.000776	0.002100	0.00514
0.9	7.94	0.992	0.00363	0.000776	0.002110	0.00515
1.0	10.00	0.992	0.00363	0.000776	0.002110	0.00515
1.1	12.60	0.992	0.00363	0.000776	0.002110	0.00515
1.2	15.80	0.992	0.00363	0.000776	0.002110	0.00515
1.3	20.00	0.992	0.00348	0.000759	0.001990	0.00497
1.4	25.10	0.992	0.00348	0.000759	0.001990	0.00497
1.5	31.60	0.992	0.00348	0.000759	0.001990	0.00497
1.6	39.80	0.991	0.00348	0.000760	0.002000	0.00497
1.7	50.10	0.991	0.00348	0.000760	0.002000	0.00497
1.8	63.10	0.991	0.00348	0.000760	0.002000	0.00497
1.9	79.40	0.991	0.00348	0.000760	0.002000	0.00497
2.0	100.00	0.991	0.00348	0.000760	0.002000	0.00497
2.1	126.00	0.991	0.00348	0.000760	0.002000	0.00497
2.2	158.00	0.991	0.00348	0.000760	0.002000	0.00497
2.3	200.00	0.989	0.00349	0.000761	0.002000	0.00499
2.4	251.00	0.986	0.00350	0.000763	0.002010	0.00500
2.5	316.00	0.986	0.00350	0.000763	0.002010	0.00500
2.6	398.00	0.986	0.00350	0.000763	0.002010	0.00500
2.7	501.00	0.986	0.00350	0.000763	0.002010	0.00500
2.8	631.00	0.981	0.00351	0.000765	0.002010	0.00501
2.9	794.00	0.981	0.00351	0.000765	0.002010	0.00501
3.0	1000.00	0.981	0.00337	0.000748	0.001900	0.00483
3.1	1260.00	0.977	0.00339	0.000753	0.001920	0.00487
3.2	1580.00	0.972	0.00341	0.000755	0.001930	0.00489
3.3	2000.00	0.960	0.00345	0.000766	0.001950	0.00496
3.4	2510.00	0.956	0.00347	0.000769	0.001960	0.00497
3.5	3160.00	0.956	0.00331	0.000750	0.001840	0.00478
3.6	3980.00	0.950	0.00318	0.000735	0.001740	0.00462
3.7	5010.00	0.931	0.00293	0.000711	0.001540	0.00433
3.8	6310.00	0.914	0.00298	0.000723	0.001560	0.00440
3.9	7940.00	0.905	0.00302	0.000733	0.001580	0.00446
4.0	10000.00	0.829	0.00297	0.000761	0.001480	0.00446
4.1	12600.00	0.751	0.00308	0.000817	0.001480	0.00468
4.2	15800.00	0.683	0.00277	0.000813	0.001180	0.00436
4.3	20000.00	0.558	0.00321	0.000986	0.001270	0.00514
4.4	25100.00	0.314	0.00400	0.001620	0.000831	0.00717

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.217	0.214	-0.2020	0.636
0.1	0.997	1.26	0.217	0.222	-0.2180	0.652
0.2	0.997	1.58	0.217	0.222	-0.2180	0.652
0.3	0.997	2.00	0.217	0.222	-0.2180	0.652
0.4	0.997	2.51	0.217	0.222	-0.2180	0.652
0.5	0.997	3.16	0.217	0.222	-0.2180	0.652
0.6	0.995	3.98	0.217	0.222	-0.2180	0.652
0.7	0.994	5.01	0.217	0.222	-0.2180	0.653
0.8	0.994	6.31	0.217	0.222	-0.2180	0.653
0.9	0.992	7.94	0.217	0.222	-0.2180	0.653
1.0	0.992	10.00	0.217	0.222	-0.2180	0.653
1.1	0.992	12.60	0.217	0.222	-0.2180	0.653
1.2	0.992	15.80	0.217	0.222	-0.2180	0.653
1.3	0.992	20.00	0.245	0.216	-0.1780	0.669
1.4	0.992	25.10	0.245	0.216	-0.1780	0.669
1.5	0.992	31.60	0.245	0.216	-0.1780	0.669
1.6	0.991	39.80	0.245	0.216	-0.1780	0.669
1.7	0.991	50.10	0.245	0.216	-0.1780	0.669
1.8	0.991	63.10	0.245	0.216	-0.1780	0.669
1.9	0.991	79.40	0.245	0.216	-0.1780	0.669
2.0	0.991	100.00	0.245	0.216	-0.1780	0.669
2.1	0.991	126.00	0.245	0.216	-0.1780	0.669
2.2	0.991	158.00	0.245	0.216	-0.1780	0.669
2.3	0.989	200.00	0.245	0.216	-0.1790	0.669
2.4	0.986	251.00	0.245	0.217	-0.1790	0.670
2.5	0.986	316.00	0.245	0.217	-0.1790	0.670
2.6	0.986	398.00	0.245	0.217	-0.1790	0.670
2.7	0.986	501.00	0.245	0.217	-0.1790	0.670
2.8	0.981	631.00	0.245	0.217	-0.1800	0.671
2.9	0.981	794.00	0.245	0.217	-0.1800	0.671
3.0	0.981	1000.00	0.261	0.212	-0.1550	0.677
3.1	0.977	1260.00	0.261	0.213	-0.1560	0.679
3.2	0.972	1580.00	0.261	0.213	-0.1570	0.680
3.3	0.960	2000.00	0.261	0.215	-0.1600	0.683
3.4	0.956	2510.00	0.261	0.216	-0.1610	0.684
3.5	0.956	3160.00	0.284	0.210	-0.1280	0.695
3.6	0.950	3980.00	0.313	0.204	-0.0872	0.713
3.7	0.931	5010.00	0.353	0.195	-0.0300	0.735
3.8	0.914	6310.00	0.353	0.197	-0.0341	0.740
3.9	0.905	7940.00	0.353	0.199	-0.0373	0.743
4.0	0.829	10000.00	0.353	0.204	-0.0470	0.752
4.1	0.751	12600.00	0.353	0.214	-0.0663	0.772
4.2	0.683	15800.00	0.356	0.213	-0.0605	0.773
4.3	0.558	20000.00	0.356	0.244	-0.1230	0.835
4.4	0.314	25100.00	0.356	0.369	-0.3680	1.080

IgG3_A244D11K169

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00362	0.000724	0.002200	0.00504
0.1	0.994	1.26	0.00362	0.000776	0.002100	0.00514
0.2	0.994	1.58	0.00350	0.000759	0.002010	0.00499
0.3	0.994	2.00	0.00350	0.000759	0.002010	0.00499
0.4	0.990	2.51	0.00350	0.000763	0.002000	0.00499
0.5	0.988	3.16	0.00350	0.000764	0.002000	0.00500
0.6	0.988	3.98	0.00350	0.000764	0.002000	0.00500
0.7	0.986	5.01	0.00342	0.000746	0.001960	0.00488
0.8	0.979	6.31	0.00342	0.000750	0.001950	0.00489
0.9	0.979	7.94	0.00342	0.000750	0.001950	0.00489
1.0	0.979	10.00	0.00342	0.000750	0.001950	0.00489
1.1	0.968	12.60	0.00342	0.000756	0.001940	0.00490
1.2	0.962	15.80	0.00342	0.000763	0.001920	0.00491
1.3	0.954	20.00	0.00342	0.000750	0.001950	0.00489
1.4	0.942	25.10	0.00342	0.000762	0.001920	0.00491
1.5	0.924	31.60	0.00342	0.000774	0.001900	0.00494
1.6	0.909	39.80	0.00342	0.000789	0.001870	0.00497
1.7	0.887	50.10	0.00342	0.000787	0.001880	0.00496
1.8	0.851	63.10	0.00342	0.000821	0.001810	0.00503
1.9	0.806	79.40	0.00342	0.000850	0.001750	0.00508
2.0	0.761	100.00	0.00319	0.000820	0.001580	0.00479
2.1	0.676	126.00	0.00317	0.000808	0.001590	0.00476
2.2	0.580	158.00	0.00317	0.000971	0.001270	0.00508
2.3	0.502	200.00	0.00317	0.001100	0.001020	0.00533
2.4	0.370	251.00	0.00317	0.001160	0.000906	0.00544
2.5	0.297	316.00	0.00317	0.001470	0.000301	0.00604
2.6	0.236	398.00	0.00317	0.001830	-0.000414	0.00676
2.7	0.193	501.00	0.00317	0.002150	-0.001030	0.00738
2.8	0.136	631.00	0.00317	0.002720	-0.002160	0.00850
2.9	0.092	794.00	0.00317	0.003120	-0.002930	0.00928

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	0.002100	0.00513
0.1	1.26	0.994	0.00362	0.000776	0.002100	0.00514
0.2	1.58	0.994	0.00348	0.000759	0.001990	0.00497
0.3	2.00	0.994	0.00348	0.000759	0.001990	0.00497
0.4	2.51	0.990	0.00351	0.000763	0.002010	0.00500
0.5	3.16	0.988	0.00351	0.000764	0.002020	0.00501
0.6	3.98	0.988	0.00351	0.000764	0.002020	0.00501
0.7	5.01	0.986	0.00337	0.000746	0.001900	0.00483
0.8	6.31	0.979	0.00339	0.000750	0.001920	0.00486
0.9	7.94	0.979	0.00339	0.000750	0.001920	0.00486
1.0	10.00	0.979	0.00339	0.000750	0.001920	0.00486
1.1	12.60	0.968	0.00341	0.000756	0.001930	0.00489
1.2	15.80	0.962	0.00344	0.000763	0.001940	0.00493
1.3	20.00	0.954	0.00331	0.000750	0.001840	0.00478
1.4	25.10	0.942	0.00337	0.000762	0.001870	0.00486
1.5	31.60	0.924	0.00342	0.000774	0.001900	0.00494
1.6	39.80	0.909	0.00348	0.000789	0.001930	0.00503
1.7	50.10	0.887	0.00339	0.000787	0.001850	0.00494
1.8	63.10	0.851	0.00354	0.000821	0.001930	0.00515
1.9	79.40	0.806	0.00357	0.000850	0.001900	0.00523
2.0	100.00	0.761	0.00319	0.000820	0.001580	0.00479
2.1	126.00	0.676	0.00275	0.000808	0.001170	0.00434
2.2	158.00	0.580	0.00327	0.000971	0.001360	0.00517
2.3	200.00	0.502	0.00355	0.001100	0.001390	0.00570
2.4	251.00	0.370	0.00306	0.001160	0.000795	0.00533
2.5	316.00	0.297	0.00381	0.001470	0.000940	0.00668
2.6	398.00	0.236	0.00438	0.001830	0.000796	0.00797
2.7	501.00	0.193	0.00472	0.002150	0.000519	0.00893
2.8	631.00	0.136	0.00489	0.002720	-0.000440	0.01020
2.9	794.00	0.092	0.00473	0.003120	-0.001380	0.01080

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.218	0.214	-0.201	0.637
0.1	0.994	1.26	0.218	0.222	-0.217	0.653
0.2	0.994	1.58	0.244	0.216	-0.180	0.667
0.3	0.994	2.00	0.244	0.216	-0.180	0.667
0.4	0.990	2.51	0.244	0.217	-0.181	0.669
0.5	0.988	3.16	0.244	0.217	-0.181	0.669
0.6	0.988	3.98	0.244	0.217	-0.181	0.669
0.7	0.986	5.01	0.261	0.212	-0.154	0.677
0.8	0.979	6.31	0.261	0.213	-0.155	0.678
0.9	0.979	7.94	0.261	0.213	-0.155	0.678
1.0	0.979	10.00	0.261	0.213	-0.155	0.678
1.1	0.968	12.60	0.261	0.214	-0.157	0.680
1.2	0.962	15.80	0.261	0.215	-0.160	0.682
1.3	0.954	20.00	0.261	0.213	-0.155	0.678
1.4	0.942	25.10	0.261	0.215	-0.159	0.682
1.5	0.924	31.60	0.261	0.217	-0.163	0.686
1.6	0.909	39.80	0.261	0.219	-0.168	0.691
1.7	0.887	50.10	0.261	0.219	-0.167	0.690
1.8	0.851	63.10	0.261	0.225	-0.179	0.701
1.9	0.806	79.40	0.261	0.229	-0.188	0.711
2.0	0.761	100.00	0.312	0.219	-0.117	0.740
2.1	0.676	126.00	0.314	0.216	-0.109	0.738
2.2	0.580	158.00	0.314	0.246	-0.167	0.796
2.3	0.502	200.00	0.314	0.270	-0.214	0.843
2.4	0.370	251.00	0.314	0.281	-0.236	0.864
2.5	0.297	316.00	0.314	0.341	-0.355	0.983
2.6	0.236	398.00	0.314	0.416	-0.500	1.130
2.7	0.193	501.00	0.314	0.481	-0.628	1.260
2.8	0.136	631.00	0.314	0.601	-0.864	1.490
2.9	0.092	794.00	0.314	0.685	-1.030	1.660

IgG3_gp70ClAEV1V2

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00361	0.000724	0.002190	0.00503
0.1	0.9840	1.26	0.00354	0.000765	0.002040	0.00504
0.2	0.9840	1.58	0.00354	0.000765	0.002040	0.00504
0.3	0.9840	2.00	0.00354	0.000765	0.002040	0.00504
0.4	0.9830	2.51	0.00354	0.000766	0.002040	0.00504
0.5	0.9810	3.16	0.00354	0.000767	0.002040	0.00504
0.6	0.9810	3.98	0.00354	0.000767	0.002040	0.00504
0.7	0.9810	5.01	0.00354	0.000767	0.002040	0.00504
0.8	0.9770	6.31	0.00354	0.000770	0.002030	0.00505
0.9	0.9730	7.94	0.00354	0.000772	0.002030	0.00505
1.0	0.9730	10.00	0.00354	0.000772	0.002030	0.00505
1.1	0.9660	12.60	0.00354	0.000776	0.002020	0.00506
1.2	0.9660	15.80	0.00354	0.000776	0.002020	0.00506
1.3	0.9660	20.00	0.00354	0.000776	0.002020	0.00506
1.4	0.9660	25.10	0.00354	0.000776	0.002020	0.00506
1.5	0.9630	31.60	0.00354	0.000778	0.002010	0.00506
1.6	0.9530	39.80	0.00335	0.000750	0.001880	0.00482
1.7	0.9490	50.10	0.00335	0.000752	0.001880	0.00482
1.8	0.9470	63.10	0.00335	0.000753	0.001870	0.00483
1.9	0.9390	79.40	0.00335	0.000760	0.001860	0.00484
2.0	0.9330	100.00	0.00335	0.000764	0.001850	0.00485
2.1	0.9110	126.00	0.00335	0.000763	0.001850	0.00485
2.2	0.8890	158.00	0.00335	0.000785	0.001810	0.00489
2.3	0.8780	200.00	0.00335	0.000794	0.001790	0.00491
2.4	0.8660	251.00	0.00335	0.000763	0.001860	0.00484
2.5	0.8320	316.00	0.00335	0.000791	0.001800	0.00490
2.6	0.8070	398.00	0.00335	0.000792	0.001800	0.00490
2.7	0.7200	501.00	0.00335	0.000847	0.001690	0.00501
2.8	0.6820	631.00	0.00335	0.000895	0.001590	0.00511
2.9	0.6430	794.00	0.00335	0.000888	0.001610	0.00509
3.0	0.5850	1000.00	0.00335	0.000980	0.001430	0.00527
3.1	0.5130	1260.00	0.00335	0.001050	0.001290	0.00541
3.2	0.4480	1580.00	0.00335	0.001180	0.001050	0.00565
3.3	0.3480	2000.00	0.00335	0.001430	0.000553	0.00615
3.4	0.3010	2510.00	0.00335	0.001630	0.000157	0.00654
3.5	0.2480	3160.00	0.00335	0.001910	-0.000388	0.00709
3.6	0.2030	3980.00	0.00335	0.002040	-0.000658	0.00736
3.7	0.1640	5010.00	0.00335	0.002440	-0.001430	0.00813
3.8	0.1150	6310.00	0.00335	0.002940	-0.002420	0.00912
3.9	0.0801	7940.00	0.00335	0.004710	-0.005880	0.01260
4.0	0.0654	10000.00	0.00335	0.006400	-0.009200	0.01590

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00361	0.000724	0.002100	0.00513
0.1	1.26	0.9840	0.00352	0.000765	0.002020	0.00501
0.2	1.58	0.9840	0.00352	0.000765	0.002020	0.00501
0.3	2.00	0.9840	0.00352	0.000765	0.002020	0.00501
0.4	2.51	0.9830	0.00352	0.000766	0.002020	0.00502
0.5	3.16	0.9810	0.00352	0.000767	0.002020	0.00502
0.6	3.98	0.9810	0.00352	0.000767	0.002020	0.00502
0.7	5.01	0.9810	0.00352	0.000767	0.002020	0.00502
0.8	6.31	0.9770	0.00354	0.000770	0.002030	0.00505
0.9	7.94	0.9730	0.00355	0.000772	0.002030	0.00506
1.0	10.00	0.9730	0.00355	0.000772	0.002030	0.00506
1.1	12.60	0.9660	0.00356	0.000776	0.002040	0.00508
1.2	15.80	0.9660	0.00356	0.000776	0.002040	0.00508
1.3	20.00	0.9660	0.00356	0.000776	0.002040	0.00508
1.4	25.10	0.9660	0.00356	0.000776	0.002040	0.00508
1.5	31.60	0.9630	0.00358	0.000778	0.002050	0.00510
1.6	39.80	0.9530	0.00331	0.000750	0.001840	0.00478
1.7	50.10	0.9490	0.00332	0.000752	0.001850	0.00480
1.8	63.10	0.9470	0.00333	0.000753	0.001850	0.00480
1.9	79.40	0.9390	0.00336	0.000760	0.001870	0.00485
2.0	100.00	0.9330	0.00337	0.000764	0.001870	0.00487
2.1	126.00	0.9110	0.00329	0.000763	0.001800	0.00479
2.2	158.00	0.8890	0.00338	0.000785	0.001840	0.00492
2.3	200.00	0.8780	0.00342	0.000794	0.001860	0.00497
2.4	251.00	0.8660	0.00314	0.000763	0.001640	0.00463
2.5	316.00	0.8320	0.00324	0.000791	0.001690	0.00480
2.6	398.00	0.8070	0.00316	0.000792	0.001610	0.00471
2.7	501.00	0.7200	0.00317	0.000847	0.001510	0.00483
2.8	631.00	0.6820	0.00336	0.000895	0.001600	0.00511
2.9	794.00	0.6430	0.00313	0.000888	0.001390	0.00487
3.0	1000.00	0.5850	0.00343	0.000980	0.001510	0.00536
3.1	1260.00	0.5130	0.00341	0.001050	0.001350	0.00546
3.2	1580.00	0.4480	0.00364	0.001180	0.001340	0.00594
3.3	2000.00	0.3480	0.00418	0.001430	0.001380	0.00697
3.4	2510.00	0.3010	0.00448	0.001630	0.001280	0.00767
3.5	3160.00	0.2480	0.00486	0.001910	0.001120	0.00859
3.6	3980.00	0.2030	0.00456	0.002040	0.000557	0.00857
3.7	5010.00	0.1640	0.00499	0.002440	0.000211	0.00976
3.8	6310.00	0.1150	0.00528	0.002940	-0.000492	0.01100
3.9	7940.00	0.0801	0.00811	0.004710	-0.001120	0.01730
4.0	10000.00	0.0654	0.00987	0.006400	-0.002680	0.02240

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.220	0.214	-0.199	0.638
0.1	0.9840	1.26	0.235	0.218	-0.192	0.663
0.2	0.9840	1.58	0.235	0.218	-0.192	0.663
0.3	0.9840	2.00	0.235	0.218	-0.192	0.663
0.4	0.9830	2.51	0.235	0.218	-0.193	0.663
0.5	0.9810	3.16	0.235	0.218	-0.193	0.663
0.6	0.9810	3.98	0.235	0.218	-0.193	0.663
0.7	0.9810	5.01	0.235	0.218	-0.193	0.663
0.8	0.9770	6.31	0.235	0.219	-0.194	0.664
0.9	0.9730	7.94	0.235	0.219	-0.195	0.665
1.0	0.9730	10.00	0.235	0.219	-0.195	0.665
1.1	0.9660	12.60	0.235	0.220	-0.196	0.666
1.2	0.9660	15.80	0.235	0.220	-0.196	0.666
1.3	0.9660	20.00	0.235	0.220	-0.196	0.666
1.4	0.9660	25.10	0.235	0.220	-0.196	0.666
1.5	0.9630	31.60	0.235	0.220	-0.197	0.667
1.6	0.9530	39.80	0.276	0.211	-0.137	0.689
1.7	0.9490	50.10	0.276	0.211	-0.138	0.690
1.8	0.9470	63.10	0.276	0.211	-0.138	0.690
1.9	0.9390	79.40	0.276	0.213	-0.141	0.693
2.0	0.9330	100.00	0.276	0.213	-0.142	0.694
2.1	0.9110	126.00	0.276	0.213	-0.141	0.694
2.2	0.8890	158.00	0.276	0.217	-0.149	0.701
2.3	0.8780	200.00	0.276	0.218	-0.152	0.704
2.4	0.8660	251.00	0.276	0.213	-0.141	0.693
2.5	0.8320	316.00	0.276	0.218	-0.151	0.703
2.6	0.8070	398.00	0.276	0.218	-0.151	0.703
2.7	0.7200	501.00	0.276	0.227	-0.170	0.722
2.8	0.6820	631.00	0.276	0.236	-0.186	0.738
2.9	0.6430	794.00	0.276	0.235	-0.184	0.736
3.0	0.5850	1000.00	0.276	0.251	-0.216	0.768
3.1	0.5130	1260.00	0.276	0.264	-0.241	0.793
3.2	0.4480	1580.00	0.276	0.288	-0.288	0.840
3.3	0.3480	2000.00	0.276	0.337	-0.384	0.936
3.4	0.3010	2510.00	0.276	0.377	-0.463	1.010
3.5	0.2480	3160.00	0.276	0.434	-0.574	1.130
3.6	0.2030	3980.00	0.276	0.462	-0.629	1.180
3.7	0.1640	5010.00	0.276	0.544	-0.789	1.340
3.8	0.1150	6310.00	0.276	0.650	-0.998	1.550
3.9	0.0801	7940.00	0.276	1.030	-1.740	2.290
4.0	0.0654	10000.00	0.276	1.390	-2.450	3.000

IgG3_gp70V1V2A

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00373	0.000724	0.002310	0.00515
0.1	0.931	1.26	0.00373	0.000820	0.002120	0.00534
0.2	0.923	1.58	0.00373	0.000826	0.002110	0.00535
0.3	0.922	2.00	0.00373	0.000827	0.002110	0.00535
0.4	0.916	2.51	0.00369	0.000813	0.002100	0.00529
0.5	0.914	3.16	0.00369	0.000815	0.002100	0.00529
0.6	0.894	3.98	0.00369	0.000829	0.002070	0.00532
0.7	0.882	5.01	0.00369	0.000837	0.002050	0.00533
0.8	0.867	6.31	0.00364	0.000829	0.002020	0.00527
0.9	0.849	7.94	0.00355	0.000827	0.001930	0.00517
1.0	0.824	10.00	0.00342	0.000779	0.001890	0.00494
1.1	0.778	12.60	0.00342	0.000831	0.001790	0.00505
1.2	0.722	15.80	0.00342	0.000840	0.001770	0.00507
1.3	0.668	20.00	0.00342	0.000910	0.001630	0.00520
1.4	0.565	25.10	0.00342	0.001030	0.001410	0.00543
1.5	0.518	31.60	0.00342	0.001060	0.001330	0.00551
1.6	0.471	39.80	0.00342	0.001130	0.001210	0.00562
1.7	0.385	50.10	0.00342	0.001260	0.000954	0.00588
1.8	0.318	63.10	0.00342	0.001200	0.001070	0.00577
1.9	0.241	79.40	0.00342	0.001690	0.000108	0.00673
2.0	0.213	100.00	0.00342	0.002060	-0.000626	0.00746
2.1	0.179	126.00	0.00342	0.002120	-0.000732	0.00757
2.2	0.122	158.00	0.00342	0.002650	-0.001780	0.00862
2.3	0.113	200.00	0.00342	0.002400	-0.001290	0.00813

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	0.002100	0.00513
0.1	1.26	0.931	0.00376	0.000820	0.002150	0.00536
0.2	1.58	0.923	0.00378	0.000826	0.002160	0.00540
0.3	2.00	0.922	0.00378	0.000827	0.002160	0.00541
0.4	2.51	0.916	0.00365	0.000813	0.002060	0.00525
0.5	3.16	0.914	0.00366	0.000815	0.002060	0.00525
0.6	3.98	0.894	0.00372	0.000829	0.002090	0.00534
0.7	5.01	0.882	0.00375	0.000837	0.002110	0.00539
0.8	6.31	0.867	0.00364	0.000829	0.002020	0.00527
0.9	7.94	0.849	0.00355	0.000827	0.001930	0.00517
1.0	10.00	0.824	0.00312	0.000779	0.001590	0.00464
1.1	12.60	0.778	0.00331	0.000831	0.001680	0.00494
1.2	15.80	0.722	0.00316	0.000840	0.001510	0.00481
1.3	20.00	0.668	0.00341	0.000910	0.001630	0.00520
1.4	25.10	0.565	0.00359	0.001030	0.001580	0.00560
1.5	31.60	0.518	0.00359	0.001060	0.001500	0.00568
1.6	39.80	0.471	0.00364	0.001130	0.001430	0.00584
1.7	50.10	0.385	0.00371	0.001260	0.001250	0.00617
1.8	63.10	0.318	0.00277	0.001200	0.000426	0.00512
1.9	79.40	0.241	0.00353	0.001690	0.000218	0.00684
2.0	100.00	0.213	0.00427	0.002060	0.000222	0.00831
2.1	126.00	0.179	0.00396	0.002120	-0.000188	0.00811
2.2	158.00	0.122	0.00478	0.002650	-0.000423	0.00998
2.3	200.00	0.113	0.00384	0.002400	-0.000872	0.00855

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.194	0.217	-0.232	0.619
0.1	0.931	1.26	0.194	0.232	-0.262	0.649
0.2	0.923	1.58	0.194	0.233	-0.264	0.651
0.3	0.922	2.00	0.194	0.233	-0.264	0.651
0.4	0.916	2.51	0.202	0.230	-0.249	0.653
0.5	0.914	3.16	0.202	0.230	-0.250	0.653
0.6	0.894	3.98	0.202	0.233	-0.254	0.658
0.7	0.882	5.01	0.202	0.234	-0.257	0.661
0.8	0.867	6.31	0.213	0.231	-0.241	0.667
0.9	0.849	7.94	0.232	0.229	-0.216	0.681
1.0	0.824	10.00	0.261	0.217	-0.165	0.687
1.1	0.778	12.60	0.261	0.226	-0.182	0.705
1.2	0.722	15.80	0.261	0.228	-0.185	0.708
1.3	0.668	20.00	0.261	0.240	-0.209	0.732
1.4	0.565	25.10	0.261	0.261	-0.250	0.773
1.5	0.518	31.60	0.261	0.268	-0.264	0.787
1.6	0.471	39.80	0.261	0.279	-0.286	0.809
1.7	0.385	50.10	0.261	0.305	-0.336	0.858
1.8	0.318	63.10	0.261	0.293	-0.313	0.836
1.9	0.241	79.40	0.261	0.390	-0.503	1.030
2.0	0.213	100.00	0.261	0.467	-0.653	1.180
2.1	0.179	126.00	0.261	0.478	-0.675	1.200
2.2	0.122	158.00	0.261	0.590	-0.894	1.420
2.3	0.113	200.00	0.261	0.537	-0.792	1.310

IgG3_gp70V1V2AP

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00370	0.000724	0.002280	0.00512
0.1	0.932	1.26	0.00370	0.000806	0.002120	0.00527
0.2	0.932	1.58	0.00370	0.000806	0.002120	0.00527
0.3	0.916	2.00	0.00370	0.000820	0.002090	0.00530
0.4	0.907	2.51	0.00370	0.000814	0.002100	0.00529
0.5	0.894	3.16	0.00370	0.000822	0.002080	0.00531
0.6	0.871	3.98	0.00370	0.000839	0.002050	0.00534
0.7	0.846	5.01	0.00357	0.000822	0.001950	0.00518
0.8	0.831	6.31	0.00357	0.000839	0.001920	0.00521
0.9	0.787	7.94	0.00340	0.000832	0.001770	0.00504
1.0	0.745	10.00	0.00340	0.000826	0.001790	0.00502
1.1	0.709	12.60	0.00340	0.000874	0.001690	0.00512
1.2	0.648	15.80	0.00340	0.000935	0.001570	0.00524
1.3	0.580	20.00	0.00340	0.000983	0.001480	0.00533
1.4	0.473	25.10	0.00340	0.001110	0.001240	0.00557
1.5	0.413	31.60	0.00337	0.001140	0.001130	0.00561
1.6	0.336	39.80	0.00337	0.001180	0.001050	0.00569
1.7	0.291	50.10	0.00337	0.001300	0.000822	0.00592
1.8	0.219	63.10	0.00337	0.001590	0.000262	0.00648
1.9	0.178	79.40	0.00337	0.002100	-0.000736	0.00748
2.0	0.165	100.00	0.00320	0.001870	-0.000460	0.00686
2.1	0.149	126.00	0.00320	0.002190	-0.001100	0.00750

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	0.002100	0.00513
0.1	1.26	0.932	0.00370	0.000806	0.002120	0.00528
0.2	1.58	0.932	0.00370	0.000806	0.002120	0.00528
0.3	2.00	0.916	0.00376	0.000820	0.002150	0.00537
0.4	2.51	0.907	0.00366	0.000814	0.002060	0.00526
0.5	3.16	0.894	0.00369	0.000822	0.002080	0.00530
0.6	3.98	0.871	0.00376	0.000839	0.002120	0.00541
0.7	5.01	0.846	0.00353	0.000822	0.001920	0.00514
0.8	6.31	0.831	0.00360	0.000839	0.001960	0.00525
0.9	7.94	0.787	0.00340	0.000832	0.001760	0.00503
1.0	10.00	0.745	0.00320	0.000826	0.001580	0.00481
1.1	12.60	0.709	0.00337	0.000874	0.001660	0.00508
1.2	15.80	0.648	0.00350	0.000935	0.001660	0.00533
1.3	20.00	0.580	0.00344	0.000983	0.001520	0.00537
1.4	25.10	0.473	0.00357	0.001110	0.001400	0.00574
1.5	31.60	0.413	0.00337	0.001140	0.001130	0.00561
1.6	39.80	0.336	0.00294	0.001180	0.000623	0.00526
1.7	50.10	0.291	0.00298	0.001300	0.000432	0.00553
1.8	63.10	0.219	0.00333	0.001590	0.000217	0.00643
1.9	79.40	0.178	0.00428	0.002100	0.000173	0.00839
2.0	100.00	0.165	0.00294	0.001870	-0.000723	0.00659
2.1	126.00	0.149	0.00346	0.002190	-0.000840	0.00776

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.201	0.216	-0.222	0.624
0.1	0.932	1.26	0.201	0.229	-0.247	0.650
0.2	0.932	1.58	0.201	0.229	-0.247	0.650
0.3	0.916	2.00	0.201	0.231	-0.252	0.655
0.4	0.907	2.51	0.201	0.230	-0.250	0.653
0.5	0.894	3.16	0.201	0.232	-0.253	0.655
0.6	0.871	3.98	0.201	0.235	-0.258	0.661
0.7	0.846	5.01	0.229	0.228	-0.218	0.677
0.8	0.831	6.31	0.229	0.231	-0.224	0.683
0.9	0.787	7.94	0.264	0.226	-0.179	0.707
1.0	0.745	10.00	0.264	0.225	-0.177	0.705
1.1	0.709	12.60	0.264	0.233	-0.193	0.722
1.2	0.648	15.80	0.264	0.244	-0.214	0.743
1.3	0.580	20.00	0.264	0.253	-0.231	0.760
1.4	0.473	25.10	0.264	0.275	-0.276	0.804
1.5	0.413	31.60	0.272	0.282	-0.280	0.824
1.6	0.336	39.80	0.272	0.289	-0.296	0.839
1.7	0.291	50.10	0.272	0.312	-0.340	0.883
1.8	0.219	63.10	0.272	0.369	-0.451	0.994
1.9	0.178	79.40	0.272	0.473	-0.655	1.200
2.0	0.165	100.00	0.309	0.423	-0.521	1.140
2.1	0.149	126.00	0.309	0.491	-0.654	1.270

IgG3_gp70V1V2C

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00361	0.000724	2.19e-03	0.00503
0.1	0.927	1.26	0.00313	0.000729	1.70e-03	0.00456
0.2	0.922	1.58	0.00313	0.000733	1.70e-03	0.00457
0.3	0.918	2.00	0.00313	0.000736	1.69e-03	0.00458
0.4	0.914	2.51	0.00313	0.000741	1.68e-03	0.00459
0.5	0.907	3.16	0.00313	0.000750	1.66e-03	0.00460
0.6	0.888	3.98	0.00313	0.000746	1.67e-03	0.00460
0.7	0.874	5.01	0.00313	0.000755	1.65e-03	0.00461
0.8	0.851	6.31	0.00313	0.000751	1.66e-03	0.00461
0.9	0.827	7.94	0.00313	0.000773	1.62e-03	0.00465
1.0	0.801	10.00	0.00313	0.000774	1.62e-03	0.00465
1.1	0.753	12.60	0.00313	0.000826	1.51e-03	0.00475
1.2	0.717	15.80	0.00313	0.000838	1.49e-03	0.00478
1.3	0.656	20.00	0.00313	0.000905	1.36e-03	0.00491
1.4	0.605	25.10	0.00313	0.000875	1.42e-03	0.00485
1.5	0.544	31.60	0.00313	0.000973	1.23e-03	0.00504
1.6	0.490	39.80	0.00313	0.001050	1.08e-03	0.00519
1.7	0.444	50.10	0.00313	0.001070	1.04e-03	0.00523
1.8	0.362	63.10	0.00287	0.001160	6.10e-04	0.00514
1.9	0.303	79.40	0.00275	0.001210	3.67e-04	0.00513
2.0	0.274	100.00	0.00275	0.001140	5.20e-04	0.00498
2.1	0.215	126.00	0.00275	0.001440	-7.36e-05	0.00557
2.2	0.180	158.00	0.00275	0.001730	-6.48e-04	0.00614
2.3	0.133	200.00	0.00275	0.002470	-2.10e-03	0.00759

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	0.002100	0.00513
0.1	1.26	0.927	0.00308	0.000729	0.001650	0.00451
0.2	1.58	0.922	0.00309	0.000733	0.001660	0.00453
0.3	2.00	0.918	0.00311	0.000736	0.001660	0.00455
0.4	2.51	0.914	0.00313	0.000741	0.001670	0.00458
0.5	3.16	0.907	0.00316	0.000750	0.001690	0.00463
0.6	3.98	0.888	0.00307	0.000746	0.001610	0.00454
0.7	5.01	0.874	0.00311	0.000755	0.001630	0.00459
0.8	6.31	0.851	0.00301	0.000751	0.001540	0.00448
0.9	7.94	0.827	0.00310	0.000773	0.001580	0.00461
1.0	10.00	0.801	0.00301	0.000774	0.001500	0.00453
1.1	12.60	0.753	0.00321	0.000826	0.001590	0.00483
1.2	15.80	0.717	0.00316	0.000838	0.001520	0.00480
1.3	20.00	0.656	0.00339	0.000905	0.001620	0.00517
1.4	25.10	0.605	0.00297	0.000875	0.001250	0.00468
1.5	31.60	0.544	0.00327	0.000973	0.001360	0.00517
1.6	39.80	0.490	0.00336	0.001050	0.001310	0.00541
1.7	50.10	0.444	0.00313	0.001070	0.001040	0.00523
1.8	63.10	0.362	0.00287	0.001160	0.000610	0.00514
1.9	79.40	0.303	0.00256	0.001210	0.000185	0.00494
2.0	100.00	0.274	0.00190	0.001140	-0.000328	0.00413
2.1	126.00	0.215	0.00239	0.001440	-0.000428	0.00521
2.2	158.00	0.180	0.00287	0.001730	-0.000528	0.00626
2.3	200.00	0.133	0.00401	0.002470	-0.000835	0.00886

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.220	0.214	-0.1990	0.638
0.1	0.927	1.26	0.323	0.202	-0.0728	0.718
0.2	0.922	1.58	0.323	0.202	-0.0740	0.720
0.3	0.918	2.00	0.323	0.203	-0.0749	0.721
0.4	0.914	2.51	0.323	0.204	-0.0767	0.722
0.5	0.907	3.16	0.323	0.205	-0.0796	0.725
0.6	0.888	3.98	0.323	0.205	-0.0785	0.724
0.7	0.874	5.01	0.323	0.206	-0.0814	0.727
0.8	0.851	6.31	0.323	0.206	-0.0800	0.726
0.9	0.827	7.94	0.323	0.209	-0.0873	0.733
1.0	0.801	10.00	0.323	0.209	-0.0876	0.733
1.1	0.753	12.60	0.323	0.219	-0.1050	0.751
1.2	0.717	15.80	0.323	0.221	-0.1100	0.756
1.3	0.656	20.00	0.323	0.233	-0.1330	0.779
1.4	0.605	25.10	0.323	0.227	-0.1230	0.768
1.5	0.544	31.60	0.323	0.245	-0.1580	0.803
1.6	0.490	39.80	0.323	0.259	-0.1850	0.831
1.7	0.444	50.10	0.323	0.263	-0.1930	0.839
1.8	0.362	63.10	0.379	0.275	-0.1610	0.918
1.9	0.303	79.40	0.406	0.285	-0.1520	0.964
2.0	0.274	100.00	0.406	0.269	-0.1220	0.934
2.1	0.215	126.00	0.406	0.330	-0.2410	1.050
2.2	0.180	158.00	0.406	0.390	-0.3590	1.170
2.3	0.133	200.00	0.406	0.546	-0.6630	1.480

IgG3_gp70.V1V2CaseA2

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00361	0.000724	0.002190	0.00503
0.1	0.939	1.26	0.00354	0.000786	0.002000	0.00507
0.2	0.939	1.58	0.00354	0.000786	0.002000	0.00507
0.3	0.934	2.00	0.00339	0.000768	0.001880	0.00489
0.4	0.922	2.51	0.00331	0.000757	0.001830	0.00480
0.5	0.909	3.16	0.00331	0.000767	0.001810	0.00482
0.6	0.891	3.98	0.00331	0.000764	0.001820	0.00481
0.7	0.873	5.01	0.00331	0.000778	0.001790	0.00484
0.8	0.849	6.31	0.00331	0.000799	0.001750	0.00488
0.9	0.821	7.94	0.00331	0.000825	0.001700	0.00493
1.0	0.785	10.00	0.00330	0.000815	0.001710	0.00490
1.1	0.710	12.60	0.00330	0.000866	0.001610	0.00500
1.2	0.656	15.80	0.00330	0.000887	0.001570	0.00504
1.3	0.640	20.00	0.00330	0.000907	0.001530	0.00508
1.4	0.578	25.10	0.00330	0.000974	0.001400	0.00521
1.5	0.487	31.60	0.00322	0.001020	0.001220	0.00522
1.6	0.428	39.80	0.00322	0.001120	0.001030	0.00541
1.7	0.350	50.10	0.00272	0.001100	0.000566	0.00488
1.8	0.312	63.10	0.00272	0.001070	0.000624	0.00483
1.9	0.256	79.40	0.00272	0.001120	0.000521	0.00493
2.0	0.228	100.00	0.00272	0.001380	0.000029	0.00542
2.1	0.161	126.00	0.00272	0.001940	-0.001070	0.00652
2.2	0.122	158.00	0.00272	0.002620	-0.002420	0.00787

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	0.002100	0.00513
0.1	1.26	0.939	0.00354	0.000786	0.002000	0.00507
0.2	1.58	0.939	0.00354	0.000786	0.002000	0.00507
0.3	2.00	0.934	0.00339	0.000768	0.001880	0.00489
0.4	2.51	0.922	0.00327	0.000757	0.001780	0.00475
0.5	3.16	0.909	0.00331	0.000767	0.001810	0.00481
0.6	3.98	0.891	0.00322	0.000764	0.001720	0.00472
0.7	5.01	0.873	0.00328	0.000778	0.001750	0.00480
0.8	6.31	0.849	0.00336	0.000799	0.001790	0.00493
0.9	7.94	0.821	0.00346	0.000825	0.001840	0.00507
1.0	10.00	0.785	0.00325	0.000815	0.001650	0.00484
1.1	12.60	0.710	0.00335	0.000866	0.001650	0.00504
1.2	15.80	0.656	0.00323	0.000887	0.001490	0.00497
1.3	20.00	0.640	0.00330	0.000907	0.001520	0.00508
1.4	25.10	0.578	0.00341	0.000974	0.001500	0.00532
1.5	31.60	0.487	0.00315	0.001020	0.001150	0.00515
1.6	39.80	0.428	0.00330	0.001120	0.001100	0.00549
1.7	50.10	0.350	0.00251	0.001100	0.000355	0.00467
1.8	63.10	0.312	0.00224	0.001070	0.000143	0.00434
1.9	79.40	0.256	0.00188	0.001120	-0.000326	0.00408
2.0	100.00	0.228	0.00229	0.001380	-0.000405	0.00499
2.1	126.00	0.161	0.00319	0.001940	-0.000602	0.00699
2.2	158.00	0.122	0.00423	0.002620	-0.000914	0.00937

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.220	0.214	-0.1990	0.638
0.1	0.939	1.26	0.236	0.221	-0.1980	0.670
0.2	0.939	1.58	0.236	0.221	-0.1980	0.670
0.3	0.934	2.00	0.268	0.215	-0.1530	0.689
0.4	0.922	2.51	0.284	0.211	-0.1300	0.698
0.5	0.909	3.16	0.284	0.213	-0.1330	0.701
0.6	0.891	3.98	0.284	0.212	-0.1320	0.700
0.7	0.873	5.01	0.284	0.215	-0.1370	0.705
0.8	0.849	6.31	0.284	0.218	-0.1440	0.712
0.9	0.821	7.94	0.284	0.223	-0.1520	0.720
1.0	0.785	10.00	0.286	0.221	-0.1470	0.718
1.1	0.710	12.60	0.286	0.230	-0.1640	0.736
1.2	0.656	15.80	0.286	0.233	-0.1710	0.743
1.3	0.640	20.00	0.286	0.237	-0.1780	0.750
1.4	0.578	25.10	0.286	0.249	-0.2020	0.774
1.5	0.487	31.60	0.304	0.255	-0.1970	0.805
1.6	0.428	39.80	0.304	0.274	-0.2330	0.842
1.7	0.350	50.10	0.411	0.262	-0.1020	0.925
1.8	0.312	63.10	0.411	0.256	-0.0911	0.913
1.9	0.256	79.40	0.411	0.267	-0.1110	0.934
2.0	0.228	100.00	0.411	0.317	-0.2100	1.030
2.1	0.161	126.00	0.411	0.432	-0.4360	1.260
2.2	0.122	158.00	0.411	0.578	-0.7210	1.540

IgG3_gp70BCaseA2V1V2169K

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00361	0.000724	0.002190	0.00503
0.1	0.966	1.26	0.00330	0.000741	0.001840	0.00475
0.2	0.966	1.58	0.00330	0.000741	0.001840	0.00475
0.3	0.966	2.00	0.00330	0.000741	0.001840	0.00475
0.4	0.966	2.51	0.00330	0.000741	0.001840	0.00475
0.5	0.964	3.16	0.00330	0.000742	0.001840	0.00475
0.6	0.960	3.98	0.00330	0.000744	0.001840	0.00475
0.7	0.955	5.01	0.00330	0.000748	0.001830	0.00476
0.8	0.932	6.31	0.00330	0.000767	0.001790	0.00480
0.9	0.910	7.94	0.00330	0.000764	0.001800	0.00479
1.0	0.902	10.00	0.00330	0.000769	0.001790	0.00480
1.1	0.889	12.60	0.00321	0.000755	0.001730	0.00469
1.2	0.874	15.80	0.00321	0.000769	0.001700	0.00471
1.3	0.850	20.00	0.00321	0.000767	0.001710	0.00471
1.4	0.825	25.10	0.00321	0.000788	0.001660	0.00475
1.5	0.776	31.60	0.00321	0.000806	0.001630	0.00479
1.6	0.740	39.80	0.00321	0.000795	0.001650	0.00477
1.7	0.687	50.10	0.00321	0.000861	0.001520	0.00489
1.8	0.644	63.10	0.00321	0.000897	0.001450	0.00497
1.9	0.608	79.40	0.00321	0.000887	0.001470	0.00495
2.0	0.530	100.00	0.00321	0.000983	0.001280	0.00513
2.1	0.457	126.00	0.00321	0.001140	0.000980	0.00544
2.2	0.379	158.00	0.00321	0.001170	0.000911	0.00550
2.3	0.325	200.00	0.00321	0.001180	0.000889	0.00553
2.4	0.278	251.00	0.00321	0.001340	0.000588	0.00583
2.5	0.218	316.00	0.00321	0.001470	0.000320	0.00610
2.6	0.168	398.00	0.00321	0.001900	-0.000508	0.00692
2.7	0.127	501.00	0.00321	0.002630	-0.001950	0.00837

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	0.002100	0.00513
0.1	1.26	0.966	0.00327	0.000741	0.001820	0.00473
0.2	1.58	0.966	0.00327	0.000741	0.001820	0.00473
0.3	2.00	0.966	0.00327	0.000741	0.001820	0.00473
0.4	2.51	0.966	0.00327	0.000741	0.001820	0.00473
0.5	3.16	0.964	0.00328	0.000742	0.001820	0.00473
0.6	3.98	0.960	0.00329	0.000744	0.001830	0.00474
0.7	5.01	0.955	0.00331	0.000748	0.001840	0.00477
0.8	6.31	0.932	0.00338	0.000767	0.001880	0.00489
0.9	7.94	0.910	0.00330	0.000764	0.001800	0.00480
1.0	10.00	0.902	0.00332	0.000769	0.001810	0.00482
1.1	12.60	0.889	0.00318	0.000755	0.001700	0.00466
1.2	15.80	0.874	0.00324	0.000769	0.001730	0.00474
1.3	20.00	0.850	0.00315	0.000767	0.001650	0.00465
1.4	25.10	0.825	0.00323	0.000788	0.001690	0.00478
1.5	31.60	0.776	0.00321	0.000806	0.001630	0.00479
1.6	39.80	0.740	0.00299	0.000795	0.001430	0.00455
1.7	50.10	0.687	0.00323	0.000861	0.001540	0.00491
1.8	63.10	0.644	0.00326	0.000897	0.001510	0.00502
1.9	79.40	0.608	0.00301	0.000887	0.001270	0.00475
2.0	100.00	0.530	0.00319	0.000983	0.001270	0.00512
2.1	126.00	0.457	0.00367	0.001140	0.001440	0.00589
2.2	158.00	0.379	0.00312	0.001170	0.000819	0.00541
2.3	200.00	0.325	0.00274	0.001180	0.000422	0.00506
2.4	251.00	0.278	0.00279	0.001340	0.000166	0.00541
2.5	316.00	0.218	0.00273	0.001470	-0.000161	0.00562
2.6	398.00	0.168	0.00349	0.001900	-0.000223	0.00721
2.7	501.00	0.127	0.00466	0.002630	-0.000500	0.00981

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.220	0.214	-0.199	0.638
0.1	0.966	1.26	0.288	0.208	-0.120	0.695
0.2	0.966	1.58	0.288	0.208	-0.120	0.695
0.3	0.966	2.00	0.288	0.208	-0.120	0.695
0.4	0.966	2.51	0.288	0.208	-0.120	0.695
0.5	0.964	3.16	0.288	0.208	-0.120	0.695
0.6	0.960	3.98	0.288	0.208	-0.121	0.696
0.7	0.955	5.01	0.288	0.209	-0.122	0.698
0.8	0.932	6.31	0.288	0.212	-0.128	0.704
0.9	0.910	7.94	0.288	0.212	-0.128	0.703
1.0	0.902	10.00	0.288	0.213	-0.129	0.704
1.1	0.889	12.60	0.307	0.208	-0.101	0.714
1.2	0.874	15.80	0.307	0.210	-0.106	0.719
1.3	0.850	20.00	0.307	0.210	-0.105	0.718
1.4	0.825	25.10	0.307	0.214	-0.112	0.726
1.5	0.776	31.60	0.307	0.217	-0.118	0.732
1.6	0.740	39.80	0.307	0.215	-0.114	0.728
1.7	0.687	50.10	0.307	0.226	-0.137	0.750
1.8	0.644	63.10	0.307	0.233	-0.150	0.763
1.9	0.608	79.40	0.307	0.231	-0.146	0.760
2.0	0.530	100.00	0.307	0.249	-0.180	0.794
2.1	0.457	126.00	0.307	0.277	-0.237	0.851
2.2	0.379	158.00	0.307	0.284	-0.250	0.864
2.3	0.325	200.00	0.307	0.286	-0.255	0.868
2.4	0.278	251.00	0.307	0.316	-0.313	0.927
2.5	0.218	316.00	0.307	0.344	-0.367	0.980
2.6	0.168	398.00	0.307	0.430	-0.535	1.150
2.7	0.127	501.00	0.307	0.583	-0.836	1.450

IgG3_gp70BCaseA2V1V2mut3

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00361	0.000724	2.19e-03	0.00503
0.1	0.9830	1.26	0.00355	0.000766	2.04e-03	0.00505
0.2	0.9830	1.58	0.00355	0.000766	2.04e-03	0.00505
0.3	0.9830	2.00	0.00355	0.000766	2.04e-03	0.00505
0.4	0.9830	2.51	0.00355	0.000766	2.04e-03	0.00505
0.5	0.9810	3.16	0.00355	0.000767	2.04e-03	0.00505
0.6	0.9810	3.98	0.00355	0.000767	2.04e-03	0.00505
0.7	0.9770	5.01	0.00355	0.000770	2.04e-03	0.00505
0.8	0.9770	6.31	0.00355	0.000770	2.04e-03	0.00505
0.9	0.9730	7.94	0.00355	0.000772	2.03e-03	0.00506
1.0	0.9730	10.00	0.00355	0.000772	2.03e-03	0.00506
1.1	0.9660	12.60	0.00355	0.000776	2.02e-03	0.00507
1.2	0.9660	15.80	0.00355	0.000776	2.02e-03	0.00507
1.3	0.9660	20.00	0.00355	0.000776	2.02e-03	0.00507
1.4	0.9570	25.10	0.00355	0.000783	2.01e-03	0.00508
1.5	0.9530	31.60	0.00355	0.000786	2.00e-03	0.00509
1.6	0.9490	39.80	0.00336	0.000752	1.89e-03	0.00484
1.7	0.9490	50.10	0.00336	0.000752	1.89e-03	0.00484
1.8	0.9390	63.10	0.00336	0.000760	1.87e-03	0.00485
1.9	0.9250	79.40	0.00336	0.000769	1.85e-03	0.00487
2.0	0.9110	100.00	0.00336	0.000761	1.87e-03	0.00485
2.1	0.8890	126.00	0.00336	0.000783	1.83e-03	0.00490
2.2	0.8700	158.00	0.00336	0.000778	1.84e-03	0.00489
2.3	0.8460	200.00	0.00336	0.000778	1.84e-03	0.00489
2.4	0.8320	251.00	0.00336	0.000791	1.81e-03	0.00491
2.5	0.8110	316.00	0.00336	0.000787	1.82e-03	0.00490
2.6	0.7360	398.00	0.00336	0.000790	1.81e-03	0.00491
2.7	0.6820	501.00	0.00336	0.000855	1.69e-03	0.00504
2.8	0.6280	631.00	0.00336	0.000905	1.59e-03	0.00513
2.9	0.5600	794.00	0.00336	0.001020	1.37e-03	0.00536
3.0	0.4840	1000.00	0.00336	0.001120	1.17e-03	0.00555
3.1	0.4250	1260.00	0.00336	0.001240	9.24e-04	0.00580
3.2	0.3220	1580.00	0.00336	0.001600	2.17e-04	0.00650
3.3	0.2660	2000.00	0.00336	0.001730	-2.66e-05	0.00675
3.4	0.2400	2510.00	0.00336	0.001930	-4.15e-04	0.00714
3.5	0.1780	3160.00	0.00336	0.002360	-1.27e-03	0.00800
3.6	0.1400	3980.00	0.00336	0.002990	-2.50e-03	0.00922
3.7	0.0991	5010.00	0.00336	0.004080	-4.63e-03	0.01140
3.8	0.0738	6310.00	0.00336	0.005050	-6.53e-03	0.01330

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00361	0.000724	0.002100	0.00513
0.1	1.26	0.9830	0.00352	0.000766	0.002020	0.00502
0.2	1.58	0.9830	0.00352	0.000766	0.002020	0.00502
0.3	2.00	0.9830	0.00352	0.000766	0.002020	0.00502
0.4	2.51	0.9830	0.00352	0.000766	0.002020	0.00502
0.5	3.16	0.9810	0.00352	0.000767	0.002020	0.00502
0.6	3.98	0.9810	0.00352	0.000767	0.002020	0.00502
0.7	5.01	0.9770	0.00354	0.000770	0.002030	0.00505
0.8	6.31	0.9770	0.00354	0.000770	0.002030	0.00505
0.9	7.94	0.9730	0.00355	0.000772	0.002030	0.00506
1.0	10.00	0.9730	0.00355	0.000772	0.002030	0.00506
1.1	12.60	0.9660	0.00356	0.000776	0.002040	0.00508
1.2	15.80	0.9660	0.00356	0.000776	0.002040	0.00508
1.3	20.00	0.9660	0.00356	0.000776	0.002040	0.00508
1.4	25.10	0.9570	0.00360	0.000783	0.002060	0.00513
1.5	31.60	0.9530	0.00361	0.000786	0.002070	0.00515
1.6	39.80	0.9490	0.00332	0.000752	0.001850	0.00480
1.7	50.10	0.9490	0.00332	0.000752	0.001850	0.00480
1.8	63.10	0.9390	0.00336	0.000760	0.001870	0.00485
1.9	79.40	0.9250	0.00340	0.000769	0.001890	0.00490
2.0	100.00	0.9110	0.00329	0.000761	0.001790	0.00478
2.1	126.00	0.8890	0.00337	0.000783	0.001840	0.00491
2.2	158.00	0.8700	0.00328	0.000778	0.001750	0.00480
2.3	200.00	0.8460	0.00319	0.000778	0.001670	0.00472
2.4	251.00	0.8320	0.00324	0.000791	0.001690	0.00480
2.5	316.00	0.8110	0.00314	0.000787	0.001600	0.00468
2.6	398.00	0.7360	0.00288	0.000790	0.001330	0.00443
2.7	501.00	0.6820	0.00311	0.000855	0.001440	0.00479
2.8	631.00	0.6280	0.00318	0.000905	0.001410	0.00496
2.9	794.00	0.5600	0.00356	0.001020	0.001560	0.00555
3.0	1000.00	0.4840	0.00362	0.001120	0.001420	0.00581
3.1	1260.00	0.4250	0.00384	0.001240	0.001400	0.00628
3.2	1580.00	0.3220	0.00466	0.001600	0.001510	0.00780
3.3	2000.00	0.2660	0.00445	0.001730	0.001060	0.00784
3.4	2510.00	0.2400	0.00459	0.001930	0.000814	0.00837
3.5	3160.00	0.1780	0.00524	0.002360	0.000602	0.00987
3.6	3980.00	0.1400	0.00603	0.002990	0.000172	0.01190
3.7	5010.00	0.0991	0.00709	0.004080	-0.000909	0.01510
3.8	6310.00	0.0738	0.00872	0.005050	-0.001170	0.01860

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.220	0.214	-0.199	0.638
0.1	0.9830	1.26	0.234	0.218	-0.194	0.662
0.2	0.9830	1.58	0.234	0.218	-0.194	0.662
0.3	0.9830	2.00	0.234	0.218	-0.194	0.662
0.4	0.9830	2.51	0.234	0.218	-0.194	0.662
0.5	0.9810	3.16	0.234	0.219	-0.195	0.662
0.6	0.9810	3.98	0.234	0.219	-0.195	0.662
0.7	0.9770	5.01	0.234	0.219	-0.196	0.663
0.8	0.9770	6.31	0.234	0.219	-0.196	0.663
0.9	0.9730	7.94	0.234	0.219	-0.196	0.664
1.0	0.9730	10.00	0.234	0.219	-0.196	0.664
1.1	0.9660	12.60	0.234	0.220	-0.198	0.665
1.2	0.9660	15.80	0.234	0.220	-0.198	0.665
1.3	0.9660	20.00	0.234	0.220	-0.198	0.665
1.4	0.9570	25.10	0.234	0.221	-0.200	0.668
1.5	0.9530	31.60	0.234	0.222	-0.201	0.669
1.6	0.9490	39.80	0.274	0.211	-0.141	0.688
1.7	0.9490	50.10	0.274	0.211	-0.141	0.688
1.8	0.9390	63.10	0.274	0.213	-0.143	0.691
1.9	0.9250	79.40	0.274	0.214	-0.146	0.694
2.0	0.9110	100.00	0.274	0.213	-0.144	0.691
2.1	0.8890	126.00	0.274	0.217	-0.151	0.698
2.2	0.8700	158.00	0.274	0.216	-0.149	0.697
2.3	0.8460	200.00	0.274	0.216	-0.149	0.697
2.4	0.8320	251.00	0.274	0.218	-0.154	0.701
2.5	0.8110	316.00	0.274	0.217	-0.152	0.700
2.6	0.7360	398.00	0.274	0.218	-0.153	0.701
2.7	0.6820	501.00	0.274	0.229	-0.175	0.722
2.8	0.6280	631.00	0.274	0.238	-0.192	0.740
2.9	0.5600	794.00	0.274	0.258	-0.232	0.780
3.0	0.4840	1000.00	0.274	0.277	-0.269	0.817
3.1	0.4250	1260.00	0.274	0.301	-0.316	0.863
3.2	0.3220	1580.00	0.274	0.372	-0.456	1.000
3.3	0.2660	2000.00	0.274	0.397	-0.505	1.050
3.4	0.2400	2510.00	0.274	0.438	-0.584	1.130
3.5	0.1780	3160.00	0.274	0.529	-0.762	1.310
3.6	0.1400	3980.00	0.274	0.660	-1.020	1.570
3.7	0.0991	5010.00	0.274	0.892	-1.470	2.020
3.8	0.0738	6310.00	0.274	1.100	-1.880	2.430

IgG_PE_A9004SS_V1_V2_Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00361	0.000724	0.002190	0.00503
0.1	0.993	1.26	0.00325	0.000733	0.001810	0.00468
0.2	0.993	1.58	0.00325	0.000733	0.001810	0.00468
0.3	0.993	2.00	0.00325	0.000733	0.001810	0.00468
0.4	0.993	2.51	0.00325	0.000733	0.001810	0.00468
0.5	0.993	3.16	0.00325	0.000733	0.001810	0.00468
0.6	0.992	3.98	0.00325	0.000734	0.001810	0.00469
0.7	0.990	5.01	0.00325	0.000734	0.001810	0.00469
0.8	0.990	6.31	0.00325	0.000734	0.001810	0.00469
0.9	0.989	7.94	0.00325	0.000736	0.001800	0.00469
1.0	0.989	10.00	0.00325	0.000736	0.001800	0.00469
1.1	0.986	12.60	0.00325	0.000738	0.001800	0.00469
1.2	0.986	15.80	0.00325	0.000738	0.001800	0.00469
1.3	0.986	20.00	0.00325	0.000738	0.001800	0.00469
1.4	0.976	25.10	0.00325	0.000742	0.001790	0.00470
1.5	0.973	31.60	0.00325	0.000744	0.001790	0.00471
1.6	0.969	39.80	0.00301	0.000710	0.001620	0.00440
1.7	0.969	50.10	0.00301	0.000710	0.001620	0.00440
1.8	0.965	63.10	0.00301	0.000715	0.001610	0.00441
1.9	0.964	79.40	0.00287	0.000695	0.001510	0.00424
2.0	0.964	100.00	0.00272	0.000676	0.001400	0.00405
2.1	0.956	126.00	0.00259	0.000659	0.001300	0.00388
2.2	0.947	158.00	0.00259	0.000661	0.001290	0.00389
2.3	0.925	200.00	0.00256	0.000636	0.001320	0.00381
2.4	0.907	251.00	0.00256	0.000648	0.001290	0.00383
2.5	0.873	316.00	0.00256	0.000670	0.001250	0.00387
2.6	0.830	398.00	0.00256	0.000703	0.001180	0.00394
2.7	0.769	501.00	0.00256	0.000762	0.001070	0.00405
2.8	0.716	631.00	0.00256	0.000796	0.001000	0.00412
2.9	0.673	794.00	0.00236	0.000746	0.000897	0.00382
3.0	0.614	1000.00	0.00236	0.000788	0.000814	0.00390
3.1	0.536	1260.00	0.00236	0.000808	0.000774	0.00394
3.2	0.489	1580.00	0.00236	0.000887	0.000621	0.00410
3.3	0.377	2000.00	0.00236	0.001070	0.000266	0.00445
3.4	0.302	2510.00	0.00236	0.001450	-0.000475	0.00519
3.5	0.213	3160.00	0.00236	0.001730	-0.001030	0.00574

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	0.002010	0.00502
0.1	1.26	0.993	0.00323	0.000733	0.001800	0.00467
0.2	1.58	0.993	0.00323	0.000733	0.001800	0.00467
0.3	2.00	0.993	0.00323	0.000733	0.001800	0.00467
0.4	2.51	0.993	0.00323	0.000733	0.001800	0.00467
0.5	3.16	0.993	0.00323	0.000733	0.001800	0.00467
0.6	3.98	0.992	0.00324	0.000734	0.001800	0.00468
0.7	5.01	0.990	0.00324	0.000734	0.001800	0.00468
0.8	6.31	0.990	0.00324	0.000734	0.001800	0.00468
0.9	7.94	0.989	0.00325	0.000736	0.001810	0.00469
1.0	10.00	0.989	0.00325	0.000736	0.001810	0.00469
1.1	12.60	0.986	0.00326	0.000738	0.001810	0.00470
1.2	15.80	0.986	0.00326	0.000738	0.001810	0.00470
1.3	20.00	0.986	0.00326	0.000738	0.001810	0.00470
1.4	25.10	0.976	0.00328	0.000742	0.001820	0.00473
1.5	31.60	0.973	0.00328	0.000744	0.001830	0.00474
1.6	39.80	0.969	0.00300	0.000710	0.001610	0.00439
1.7	50.10	0.969	0.00300	0.000710	0.001610	0.00439
1.8	63.10	0.965	0.00302	0.000715	0.001620	0.00443
1.9	79.40	0.964	0.00287	0.000695	0.001510	0.00424
2.0	100.00	0.964	0.00272	0.000676	0.001400	0.00405
2.1	126.00	0.956	0.00259	0.000659	0.001290	0.00388
2.2	158.00	0.947	0.00260	0.000661	0.001300	0.00389
2.3	200.00	0.925	0.00235	0.000636	0.001100	0.00359
2.4	251.00	0.907	0.00239	0.000648	0.001120	0.00366
2.5	316.00	0.873	0.00247	0.000670	0.001160	0.00378
2.6	398.00	0.830	0.00258	0.000703	0.001210	0.00396
2.7	501.00	0.769	0.00280	0.000762	0.001300	0.00429
2.8	631.00	0.716	0.00282	0.000796	0.001260	0.00438
2.9	794.00	0.673	0.00235	0.000746	0.000890	0.00381
3.0	1000.00	0.614	0.00237	0.000788	0.000821	0.00391
3.1	1260.00	0.536	0.00217	0.000808	0.000582	0.00375
3.2	1580.00	0.489	0.00237	0.000887	0.000630	0.00411
3.3	2000.00	0.377	0.00241	0.001070	0.000315	0.00450
3.4	2510.00	0.302	0.00289	0.001450	0.000058	0.00573
3.5	3160.00	0.213	0.00275	0.001730	-0.000630	0.00614

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.220	0.214	-0.19900	0.638
0.1	0.993	1.26	0.298	0.205	-0.10400	0.701
0.2	0.993	1.58	0.298	0.205	-0.10400	0.701
0.3	0.993	2.00	0.298	0.205	-0.10400	0.701
0.4	0.993	2.51	0.298	0.205	-0.10400	0.701
0.5	0.993	3.16	0.298	0.205	-0.10400	0.701
0.6	0.992	3.98	0.298	0.205	-0.10500	0.701
0.7	0.990	5.01	0.298	0.206	-0.10500	0.701
0.8	0.990	6.31	0.298	0.206	-0.10500	0.701
0.9	0.989	7.94	0.298	0.206	-0.10500	0.702
1.0	0.989	10.00	0.298	0.206	-0.10500	0.702
1.1	0.986	12.60	0.298	0.206	-0.10600	0.702
1.2	0.986	15.80	0.298	0.206	-0.10600	0.702
1.3	0.986	20.00	0.298	0.206	-0.10600	0.702
1.4	0.976	25.10	0.298	0.207	-0.10700	0.704
1.5	0.973	31.60	0.298	0.207	-0.10800	0.704
1.6	0.969	39.80	0.350	0.195	-0.03330	0.733
1.7	0.969	50.10	0.350	0.195	-0.03330	0.733
1.8	0.965	63.10	0.350	0.196	-0.03510	0.734
1.9	0.964	79.40	0.379	0.190	0.00764	0.751
2.0	0.964	100.00	0.411	0.183	0.05360	0.769
2.1	0.956	126.00	0.440	0.176	0.09430	0.786
2.2	0.947	158.00	0.440	0.177	0.09330	0.787
2.3	0.925	200.00	0.447	0.172	0.11000	0.783
2.4	0.907	251.00	0.447	0.174	0.10600	0.787
2.5	0.873	316.00	0.447	0.178	0.09830	0.795
2.6	0.830	398.00	0.447	0.184	0.08670	0.807
2.7	0.769	501.00	0.447	0.194	0.06600	0.827
2.8	0.716	631.00	0.447	0.201	0.05350	0.840
2.9	0.673	794.00	0.490	0.187	0.12400	0.857
3.0	0.614	1000.00	0.490	0.195	0.10800	0.872
3.1	0.536	1260.00	0.490	0.199	0.10000	0.880
3.2	0.489	1580.00	0.490	0.214	0.07110	0.909
3.3	0.377	2000.00	0.490	0.250	0.00114	0.979
3.4	0.302	2510.00	0.490	0.327	-0.15000	1.130
3.5	0.213	3160.00	0.490	0.385	-0.26500	1.240

IgG_PE_AQ23_V1_V2_Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00361	0.000724	0.002190	0.00503
0.1	0.995	1.26	0.00342	0.000760	0.001930	0.00491
0.2	0.994	1.58	0.00342	0.000760	0.001930	0.00491
0.3	0.994	2.00	0.00342	0.000760	0.001930	0.00491
0.4	0.989	2.51	0.00342	0.000762	0.001930	0.00492
0.5	0.989	3.16	0.00342	0.000762	0.001930	0.00492
0.6	0.989	3.98	0.00342	0.000762	0.001930	0.00492
0.7	0.989	5.01	0.00331	0.000744	0.001850	0.00477
0.8	0.988	6.31	0.00331	0.000745	0.001850	0.00477
0.9	0.986	7.94	0.00331	0.000746	0.001850	0.00477
1.0	0.985	10.00	0.00331	0.000746	0.001840	0.00477
1.1	0.983	12.60	0.00331	0.000747	0.001840	0.00477
1.2	0.977	15.80	0.00331	0.000751	0.001840	0.00478
1.3	0.974	20.00	0.00331	0.000753	0.001830	0.00478
1.4	0.969	25.10	0.00331	0.000756	0.001830	0.00479
1.5	0.969	31.60	0.00331	0.000756	0.001830	0.00479
1.6	0.960	39.80	0.00321	0.000744	0.001750	0.00467
1.7	0.960	50.10	0.00306	0.000724	0.001640	0.00448
1.8	0.950	63.10	0.00264	0.000671	0.001330	0.00396
1.9	0.935	79.40	0.00264	0.000680	0.001310	0.00398
2.0	0.922	100.00	0.00253	0.000664	0.001230	0.00384
2.1	0.914	126.00	0.00253	0.000668	0.001220	0.00384
2.2	0.893	158.00	0.00235	0.000640	0.001100	0.00361
2.3	0.875	200.00	0.00235	0.000653	0.001080	0.00363
2.4	0.837	251.00	0.00235	0.000658	0.001070	0.00364
2.5	0.786	316.00	0.00235	0.000698	0.000987	0.00372
2.6	0.758	398.00	0.00235	0.000724	0.000935	0.00377
2.7	0.710	501.00	0.00235	0.000730	0.000923	0.00379
2.8	0.648	631.00	0.00226	0.000754	0.000777	0.00373
2.9	0.585	794.00	0.00226	0.000817	0.000653	0.00386
3.0	0.519	1000.00	0.00226	0.000883	0.000525	0.00398
3.1	0.469	1260.00	0.00226	0.000878	0.000534	0.00398
3.2	0.371	1580.00	0.00226	0.000977	0.000340	0.00417
3.3	0.298	2000.00	0.00226	0.001320	-0.000338	0.00485

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	2.03e-03	0.00507
0.1	1.26	0.995	0.00341	0.000760	1.93e-03	0.00490
0.2	1.58	0.994	0.00342	0.000760	1.93e-03	0.00491
0.3	2.00	0.994	0.00342	0.000760	1.93e-03	0.00491
0.4	2.51	0.989	0.00343	0.000762	1.94e-03	0.00493
0.5	3.16	0.989	0.00343	0.000762	1.94e-03	0.00493
0.6	3.98	0.989	0.00343	0.000762	1.94e-03	0.00493
0.7	5.01	0.989	0.00328	0.000744	1.82e-03	0.00474
0.8	6.31	0.988	0.00329	0.000745	1.83e-03	0.00475
0.9	7.94	0.986	0.00329	0.000746	1.83e-03	0.00476
1.0	10.00	0.985	0.00330	0.000746	1.83e-03	0.00476
1.1	12.60	0.983	0.00330	0.000747	1.84e-03	0.00477
1.2	15.80	0.977	0.00332	0.000751	1.85e-03	0.00479
1.3	20.00	0.974	0.00332	0.000753	1.85e-03	0.00480
1.4	25.10	0.969	0.00333	0.000756	1.85e-03	0.00482
1.5	31.60	0.969	0.00333	0.000756	1.85e-03	0.00482
1.6	39.80	0.960	0.00321	0.000744	1.75e-03	0.00467
1.7	50.10	0.960	0.00306	0.000724	1.64e-03	0.00448
1.8	63.10	0.950	0.00263	0.000671	1.31e-03	0.00394
1.9	79.40	0.935	0.00266	0.000680	1.33e-03	0.00400
2.0	100.00	0.922	0.00253	0.000664	1.23e-03	0.00383
2.1	126.00	0.914	0.00254	0.000668	1.23e-03	0.00385
2.2	158.00	0.893	0.00228	0.000640	1.03e-03	0.00354
2.3	200.00	0.875	0.00233	0.000653	1.05e-03	0.00361
2.4	251.00	0.837	0.00226	0.000658	9.70e-04	0.00355
2.5	316.00	0.786	0.00239	0.000698	1.02e-03	0.00376
2.6	398.00	0.758	0.00248	0.000724	1.06e-03	0.00390
2.7	501.00	0.710	0.00240	0.000730	9.71e-04	0.00383
2.8	631.00	0.648	0.00225	0.000754	7.77e-04	0.00373
2.9	794.00	0.585	0.00232	0.000817	7.17e-04	0.00392
3.0	1000.00	0.519	0.00235	0.000883	6.25e-04	0.00408
3.1	1260.00	0.469	0.00219	0.000878	4.67e-04	0.00391
3.2	1580.00	0.371	0.00206	0.000977	1.45e-04	0.00397
3.3	2000.00	0.298	0.00269	0.001320	9.59e-05	0.00528

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.220	0.214	-0.1990	0.638
0.1	0.995	1.26	0.260	0.214	-0.1600	0.680
0.2	0.994	1.58	0.260	0.214	-0.1600	0.680
0.3	0.994	2.00	0.260	0.214	-0.1600	0.680
0.4	0.989	2.51	0.260	0.215	-0.1610	0.681
0.5	0.989	3.16	0.260	0.215	-0.1610	0.681
0.6	0.989	3.98	0.260	0.215	-0.1610	0.681
0.7	0.989	5.01	0.285	0.209	-0.1240	0.694
0.8	0.988	6.31	0.285	0.209	-0.1240	0.695
0.9	0.986	7.94	0.285	0.209	-0.1240	0.695
1.0	0.985	10.00	0.285	0.209	-0.1250	0.695
1.1	0.983	12.60	0.285	0.209	-0.1250	0.695
1.2	0.977	15.80	0.285	0.210	-0.1260	0.697
1.3	0.974	20.00	0.285	0.210	-0.1270	0.697
1.4	0.969	25.10	0.285	0.211	-0.1280	0.698
1.5	0.969	31.60	0.285	0.211	-0.1280	0.698
1.6	0.960	39.80	0.306	0.206	-0.0980	0.710
1.7	0.960	50.10	0.339	0.199	-0.0513	0.729
1.8	0.950	63.10	0.428	0.180	0.0760	0.781
1.9	0.935	79.40	0.428	0.181	0.0728	0.784
2.0	0.922	100.00	0.452	0.176	0.1070	0.797
2.1	0.914	126.00	0.452	0.177	0.1060	0.799
2.2	0.893	158.00	0.491	0.168	0.1620	0.820
2.3	0.875	200.00	0.491	0.170	0.1580	0.824
2.4	0.837	251.00	0.491	0.171	0.1560	0.826
2.5	0.786	316.00	0.491	0.178	0.1420	0.840
2.6	0.758	398.00	0.491	0.183	0.1320	0.850
2.7	0.710	501.00	0.491	0.184	0.1300	0.852
2.8	0.648	631.00	0.513	0.187	0.1470	0.878
2.9	0.585	794.00	0.513	0.199	0.1230	0.902
3.0	0.519	1000.00	0.513	0.211	0.0987	0.927
3.1	0.469	1260.00	0.513	0.210	0.1000	0.925
3.2	0.371	1580.00	0.513	0.230	0.0622	0.963
3.3	0.298	2000.00	0.513	0.300	-0.0752	1.100

IgG_PE_BioRV144_V2_AE

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00361	0.000724	0.002190	0.00503
0.1	0.9740	1.26	0.00329	0.000743	0.001830	0.00474
0.2	0.9740	1.58	0.00316	0.000725	0.001740	0.00458
0.3	0.9740	2.00	0.00316	0.000725	0.001740	0.00458
0.4	0.9740	2.51	0.00316	0.000725	0.001740	0.00458
0.5	0.9740	3.16	0.00316	0.000725	0.001740	0.00458
0.6	0.9740	3.98	0.00316	0.000725	0.001740	0.00458
0.7	0.9670	5.01	0.00316	0.000727	0.001740	0.00459
0.8	0.9660	6.31	0.00316	0.000728	0.001740	0.00459
0.9	0.9530	7.94	0.00316	0.000739	0.001710	0.00461
1.0	0.9520	10.00	0.00316	0.000740	0.001710	0.00461
1.1	0.9320	12.60	0.00316	0.000752	0.001690	0.00464
1.2	0.9090	15.80	0.00316	0.000748	0.001690	0.00462
1.3	0.8990	20.00	0.00302	0.000733	0.001580	0.00446
1.4	0.8760	25.10	0.00279	0.000714	0.001390	0.00419
1.5	0.8390	31.60	0.00276	0.000715	0.001360	0.00416
1.6	0.8090	39.80	0.00276	0.000739	0.001310	0.00421
1.7	0.7800	50.10	0.00269	0.000733	0.001250	0.00412
1.8	0.7130	63.10	0.00232	0.000706	0.000939	0.00371
1.9	0.6660	79.40	0.00230	0.000729	0.000870	0.00373
2.0	0.6130	100.00	0.00230	0.000675	0.000976	0.00362
2.1	0.5840	126.00	0.00230	0.000644	0.001040	0.00356
2.2	0.4970	158.00	0.00230	0.000761	0.000808	0.00379
2.3	0.4330	200.00	0.00230	0.000882	0.000572	0.00403
2.4	0.3770	251.00	0.00230	0.001030	0.000290	0.00431
2.5	0.3120	316.00	0.00230	0.000987	0.000365	0.00423
2.6	0.2590	398.00	0.00230	0.000859	0.000615	0.00398
2.7	0.2180	501.00	0.00230	0.000959	0.000420	0.00418
2.8	0.1770	631.00	0.00230	0.001270	-0.000192	0.00479
2.9	0.1390	794.00	0.00230	0.001510	-0.000657	0.00526
3.0	0.1030	1000.00	0.00230	0.001930	-0.001480	0.00608
3.1	0.0622	1260.00	0.00230	0.003730	-0.005010	0.00961
3.2	0.0568	1580.00	0.00230	0.004040	-0.005620	0.01020

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00361	0.000724	0.002000	0.00499
0.1	1.26	0.9740	0.00329	0.000743	0.001830	0.00474
0.2	1.58	0.9740	0.00314	0.000725	0.001720	0.00456
0.3	2.00	0.9740	0.00314	0.000725	0.001720	0.00456
0.4	2.51	0.9740	0.00314	0.000725	0.001720	0.00456
0.5	3.16	0.9740	0.00314	0.000725	0.001720	0.00456
0.6	3.98	0.9740	0.00314	0.000725	0.001720	0.00456
0.7	5.01	0.9670	0.00315	0.000727	0.001720	0.00457
0.8	6.31	0.9660	0.00315	0.000728	0.001720	0.00458
0.9	7.94	0.9530	0.00320	0.000739	0.001750	0.00465
1.0	10.00	0.9520	0.00320	0.000740	0.001750	0.00465
1.1	12.60	0.9320	0.00325	0.000752	0.001780	0.00473
1.2	15.80	0.9090	0.00316	0.000748	0.001690	0.00462
1.3	20.00	0.8990	0.00302	0.000733	0.001580	0.00446
1.4	25.10	0.8760	0.00279	0.000714	0.001390	0.00419
1.5	31.60	0.8390	0.00271	0.000715	0.001310	0.00411
1.6	39.80	0.8090	0.00280	0.000739	0.001350	0.00425
1.7	50.10	0.7800	0.00269	0.000733	0.001250	0.00412
1.8	63.10	0.7130	0.00232	0.000706	0.000939	0.00371
1.9	79.40	0.6660	0.00230	0.000729	0.000866	0.00373
2.0	100.00	0.6130	0.00193	0.000675	0.000606	0.00325
2.1	126.00	0.5840	0.00174	0.000644	0.000476	0.00300
2.2	158.00	0.4970	0.00191	0.000761	0.000419	0.00340
2.3	200.00	0.4330	0.00221	0.000882	0.000483	0.00394
2.4	251.00	0.3770	0.00255	0.001030	0.000541	0.00456
2.5	316.00	0.3120	0.00207	0.000987	0.000139	0.00401
2.6	398.00	0.2590	0.00143	0.000859	-0.000259	0.00311
2.7	501.00	0.2180	0.00155	0.000959	-0.000329	0.00343
2.8	631.00	0.1770	0.00205	0.001270	-0.000442	0.00454
2.9	794.00	0.1390	0.00247	0.001510	-0.000489	0.00542
3.0	1000.00	0.1030	0.00310	0.001930	-0.000679	0.00689
3.1	1260.00	0.0622	0.00555	0.003730	-0.001760	0.01290
3.2	1580.00	0.0568	0.00630	0.004040	-0.001620	0.01420

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.220	0.214	-0.1990	0.638
0.1	0.9740	1.26	0.290	0.208	-0.1180	0.698
0.2	0.9740	1.58	0.316	0.202	-0.0793	0.712
0.3	0.9740	2.00	0.316	0.202	-0.0793	0.712
0.4	0.9740	2.51	0.316	0.202	-0.0793	0.712
0.5	0.9740	3.16	0.316	0.202	-0.0793	0.712
0.6	0.9740	3.98	0.316	0.202	-0.0793	0.712
0.7	0.9670	5.01	0.316	0.202	-0.0802	0.713
0.8	0.9660	6.31	0.316	0.202	-0.0804	0.713
0.9	0.9530	7.94	0.316	0.204	-0.0842	0.717
1.0	0.9520	10.00	0.316	0.204	-0.0845	0.717
1.1	0.9320	12.60	0.316	0.207	-0.0885	0.721
1.2	0.9090	15.80	0.318	0.205	-0.0848	0.721
1.3	0.8990	20.00	0.347	0.200	-0.0440	0.739
1.4	0.8760	25.10	0.397	0.191	0.0227	0.771
1.5	0.8390	31.60	0.404	0.190	0.0316	0.777
1.6	0.8090	39.80	0.404	0.194	0.0232	0.786
1.7	0.7800	50.10	0.419	0.192	0.0431	0.795
1.8	0.7130	63.10	0.498	0.179	0.1480	0.849
1.9	0.6660	79.40	0.503	0.183	0.1450	0.861
2.0	0.6130	100.00	0.503	0.173	0.1640	0.842
2.1	0.5840	126.00	0.503	0.167	0.1750	0.831
2.2	0.4970	158.00	0.503	0.189	0.1330	0.873
2.3	0.4330	200.00	0.503	0.212	0.0879	0.918
2.4	0.3770	251.00	0.503	0.240	0.0324	0.974
2.5	0.3120	316.00	0.503	0.233	0.0472	0.959
2.6	0.2590	398.00	0.503	0.207	0.0964	0.910
2.7	0.2180	501.00	0.503	0.227	0.0581	0.948
2.8	0.1770	631.00	0.503	0.290	-0.0652	1.070
2.9	0.1390	794.00	0.503	0.339	-0.1610	1.170
3.0	0.1030	1000.00	0.503	0.427	-0.3350	1.340
3.1	0.0622	1260.00	0.503	0.811	-1.0900	2.090
3.2	0.0568	1580.00	0.503	0.878	-1.2200	2.220

IgG_PE_BioRV144_V2_B

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00384	0.000724	0.002420	0.00526
0.1	0.842	1.26	0.00384	0.000854	0.002170	0.00552
0.2	0.838	1.58	0.00384	0.000858	0.002160	0.00553
0.3	0.828	2.00	0.00384	0.000871	0.002140	0.00555
0.4	0.790	2.51	0.00384	0.000921	0.002040	0.00565
0.5	0.774	3.16	0.00384	0.000940	0.002000	0.00569
0.6	0.769	3.98	0.00384	0.000945	0.001990	0.00570
0.7	0.755	5.01	0.00384	0.000938	0.002010	0.00568
0.8	0.717	6.31	0.00384	0.000963	0.001960	0.00573
0.9	0.698	7.94	0.00384	0.000990	0.001900	0.00578
1.0	0.685	10.00	0.00384	0.000978	0.001930	0.00576
1.1	0.651	12.60	0.00346	0.000935	0.001630	0.00529
1.2	0.584	15.80	0.00346	0.000996	0.001510	0.00541
1.3	0.543	20.00	0.00346	0.001040	0.001420	0.00550
1.4	0.499	25.10	0.00333	0.001040	0.001300	0.00536
1.5	0.462	31.60	0.00333	0.001110	0.001150	0.00551
1.6	0.414	39.80	0.00287	0.001080	0.000751	0.00499
1.7	0.358	50.10	0.00283	0.001140	0.000598	0.00507
1.8	0.281	63.10	0.00280	0.001330	0.000202	0.00540
1.9	0.241	79.40	0.00264	0.001400	-0.000104	0.00538

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00361	0.000724	0.002150	0.00526
0.1	1.26	0.842	0.00367	0.000854	0.001990	0.00534
0.2	1.58	0.838	0.00368	0.000858	0.002000	0.00536
0.3	2.00	0.828	0.00374	0.000871	0.002030	0.00544
0.4	2.51	0.790	0.00393	0.000921	0.002130	0.00574
0.5	3.16	0.774	0.00401	0.000940	0.002170	0.00585
0.6	3.98	0.769	0.00403	0.000945	0.002180	0.00588
0.7	5.01	0.755	0.00391	0.000938	0.002070	0.00575
0.8	6.31	0.717	0.00391	0.000963	0.002020	0.00580
0.9	7.94	0.698	0.00401	0.000990	0.002070	0.00595
1.0	10.00	0.685	0.00386	0.000978	0.001940	0.00577
1.1	12.60	0.651	0.00339	0.000935	0.001550	0.00522
1.2	15.80	0.584	0.00349	0.000996	0.001530	0.00544
1.3	20.00	0.543	0.00351	0.001040	0.001470	0.00555
1.4	25.10	0.499	0.00323	0.001040	0.001200	0.00526
1.5	31.60	0.462	0.00344	0.001110	0.001260	0.00562
1.6	39.80	0.414	0.00287	0.001080	0.000751	0.00499
1.7	50.10	0.358	0.00283	0.001140	0.000598	0.00507
1.8	63.10	0.281	0.00280	0.001330	0.000202	0.00540
1.9	79.40	0.241	0.00264	0.001400	-0.000104	0.00538

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.169	0.220	-0.262	0.601
0.1	0.842	1.26	0.169	0.241	-0.303	0.641
0.2	0.838	1.58	0.169	0.241	-0.304	0.643
0.3	0.828	2.00	0.169	0.244	-0.308	0.647
0.4	0.790	2.51	0.169	0.252	-0.325	0.663
0.5	0.774	3.16	0.169	0.255	-0.331	0.670
0.6	0.769	3.98	0.169	0.256	-0.333	0.671
0.7	0.755	5.01	0.169	0.255	-0.330	0.669
0.8	0.717	6.31	0.169	0.259	-0.339	0.678
0.9	0.698	7.94	0.169	0.264	-0.348	0.687
1.0	0.685	10.00	0.169	0.262	-0.344	0.683
1.1	0.651	12.60	0.253	0.245	-0.228	0.734
1.2	0.584	15.80	0.253	0.256	-0.250	0.755
1.3	0.543	20.00	0.253	0.264	-0.265	0.771
1.4	0.499	25.10	0.280	0.261	-0.232	0.792
1.5	0.462	31.60	0.280	0.275	-0.260	0.819
1.6	0.414	39.80	0.379	0.261	-0.132	0.891
1.7	0.358	50.10	0.388	0.271	-0.144	0.920
1.8	0.281	63.10	0.394	0.308	-0.210	0.998
1.9	0.241	79.40	0.430	0.320	-0.198	1.060

IgG_PE_BioRV144_V2_C

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00361	0.000724	2.19e-03	0.00503
0.1	0.9480	1.26	0.00352	0.000778	1.99e-03	0.00504
0.2	0.9470	1.58	0.00352	0.000779	1.99e-03	0.00504
0.3	0.9470	2.00	0.00352	0.000779	1.99e-03	0.00504
0.4	0.9470	2.51	0.00352	0.000779	1.99e-03	0.00504
0.5	0.9410	3.16	0.00352	0.000786	1.97e-03	0.00506
0.6	0.9350	3.98	0.00341	0.000773	1.89e-03	0.00492
0.7	0.9350	5.01	0.00341	0.000773	1.89e-03	0.00492
0.8	0.9350	6.31	0.00326	0.000754	1.78e-03	0.00474
0.9	0.9270	7.94	0.00300	0.000720	1.59e-03	0.00441
1.0	0.9050	10.00	0.00300	0.000737	1.56e-03	0.00445
1.1	0.8840	12.60	0.00297	0.000732	1.53e-03	0.00440
1.2	0.8700	15.80	0.00297	0.000745	1.51e-03	0.00443
1.3	0.8480	20.00	0.00289	0.000741	1.44e-03	0.00435
1.4	0.8050	25.10	0.00284	0.000752	1.37e-03	0.00432
1.5	0.7530	31.60	0.00280	0.000768	1.30e-03	0.00431
1.6	0.7180	39.80	0.00238	0.000719	9.68e-04	0.00379
1.7	0.6560	50.10	0.00238	0.000762	8.84e-04	0.00387
1.8	0.6040	63.10	0.00233	0.000784	7.96e-04	0.00387
1.9	0.5470	79.40	0.00233	0.000833	6.99e-04	0.00397
2.0	0.4630	100.00	0.00233	0.000854	6.57e-04	0.00401
2.1	0.4140	126.00	0.00233	0.000918	5.33e-04	0.00413
2.2	0.3610	158.00	0.00233	0.001070	2.38e-04	0.00443
2.3	0.3250	200.00	0.00233	0.001210	-3.78e-05	0.00470
2.4	0.2830	251.00	0.00233	0.001160	5.90e-05	0.00461
2.5	0.2420	316.00	0.00233	0.001270	-1.65e-04	0.00483
2.6	0.1980	398.00	0.00233	0.001540	-6.96e-04	0.00536
2.7	0.1400	501.00	0.00233	0.002290	-2.16e-03	0.00683
2.8	0.1120	631.00	0.00233	0.002170	-1.92e-03	0.00659
2.9	0.0985	794.00	0.00233	0.002290	-2.15e-03	0.00681

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00361	0.000724	0.002110	0.00517
0.1	1.26	0.9480	0.00351	0.000778	0.001980	0.00503
0.2	1.58	0.9470	0.00351	0.000779	0.001980	0.00504
0.3	2.00	0.9470	0.00351	0.000779	0.001980	0.00504
0.4	2.51	0.9470	0.00351	0.000779	0.001980	0.00504
0.5	3.16	0.9410	0.00354	0.000786	0.002000	0.00508
0.6	3.98	0.9350	0.00341	0.000773	0.001890	0.00492
0.7	5.01	0.9350	0.00341	0.000773	0.001890	0.00492
0.8	6.31	0.9350	0.00326	0.000754	0.001780	0.00474
0.9	7.94	0.9270	0.00297	0.000720	0.001560	0.00438
1.0	10.00	0.9050	0.00304	0.000737	0.001590	0.00448
1.1	12.60	0.8840	0.00294	0.000732	0.001510	0.00438
1.2	15.80	0.8700	0.00299	0.000745	0.001530	0.00445
1.3	20.00	0.8480	0.00289	0.000741	0.001440	0.00435
1.4	25.10	0.8050	0.00284	0.000752	0.001370	0.00432
1.5	31.60	0.7530	0.00280	0.000768	0.001300	0.00431
1.6	39.80	0.7180	0.00237	0.000719	0.000960	0.00378
1.7	50.10	0.6560	0.00238	0.000762	0.000891	0.00388
1.8	63.10	0.6040	0.00233	0.000784	0.000792	0.00386
1.9	79.40	0.5470	0.00233	0.000833	0.000696	0.00396
2.0	100.00	0.4630	0.00210	0.000854	0.000422	0.00377
2.1	126.00	0.4140	0.00225	0.000918	0.000455	0.00405
2.2	158.00	0.3610	0.00257	0.001070	0.000471	0.00466
2.3	200.00	0.3250	0.00289	0.001210	0.000521	0.00526
2.4	251.00	0.2830	0.00238	0.001160	0.000111	0.00466
2.5	316.00	0.2420	0.00235	0.001270	-0.000148	0.00485
2.6	398.00	0.1980	0.00285	0.001540	-0.000174	0.00588
2.7	501.00	0.1400	0.00423	0.002290	-0.000267	0.00872
2.8	631.00	0.1120	0.00348	0.002170	-0.000771	0.00774
2.9	794.00	0.0985	0.00365	0.002290	-0.000831	0.00813

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.220	0.214	-0.19900	0.638
0.1	0.9480	1.26	0.240	0.220	-0.19000	0.671
0.2	0.9470	1.58	0.240	0.220	-0.19100	0.671
0.3	0.9470	2.00	0.240	0.220	-0.19100	0.671
0.4	0.9470	2.51	0.240	0.220	-0.19100	0.671
0.5	0.9410	3.16	0.240	0.221	-0.19300	0.674
0.6	0.9350	3.98	0.263	0.216	-0.16000	0.687
0.7	0.9350	5.01	0.263	0.216	-0.16000	0.687
0.8	0.9350	6.31	0.296	0.209	-0.11400	0.706
0.9	0.9270	7.94	0.351	0.197	-0.03520	0.737
1.0	0.9050	10.00	0.351	0.200	-0.04100	0.743
1.1	0.8840	12.60	0.359	0.198	-0.02920	0.748
1.2	0.8700	15.80	0.359	0.200	-0.03370	0.752
1.3	0.8480	20.00	0.375	0.198	-0.01330	0.763
1.4	0.8050	25.10	0.385	0.199	-0.00433	0.775
1.5	0.7530	31.60	0.394	0.201	0.00114	0.788
1.6	0.7180	39.80	0.486	0.182	0.12900	0.844
1.7	0.6560	50.10	0.486	0.190	0.11300	0.860
1.8	0.6040	63.10	0.496	0.194	0.11700	0.875
1.9	0.5470	79.40	0.496	0.203	0.09810	0.894
2.0	0.4630	100.00	0.496	0.207	0.09010	0.902
2.1	0.4140	126.00	0.496	0.219	0.06600	0.926
2.2	0.3610	158.00	0.496	0.249	0.00756	0.985
2.3	0.3250	200.00	0.496	0.278	-0.04810	1.040
2.4	0.2830	251.00	0.496	0.268	-0.02850	1.020
2.5	0.2420	316.00	0.496	0.291	-0.07410	1.070
2.6	0.1980	398.00	0.496	0.347	-0.18400	1.180
2.7	0.1400	501.00	0.496	0.504	-0.49300	1.480
2.8	0.1120	631.00	0.496	0.478	-0.44200	1.430
2.9	0.0985	794.00	0.496	0.503	-0.48900	1.480

RV144 (42 month)

• Adjustment covariates: dem_sex, BRA_risk
• Event time variable: HIVwk42fu
• Event type variable: HIVwk42
• Weight variable: sample_weight
• Reference timepoint: 1014 days
• All learners: GLM

IgG V1V2 B.CaseA-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00595	0.000929	0.004130	0.00777
0.1	0.995	1.26	0.00584	0.001020	0.003840	0.00785
0.2	0.995	1.58	0.00584	0.001020	0.003840	0.00785
0.3	0.995	2.00	0.00584	0.001020	0.003840	0.00785
0.4	0.994	2.51	0.00584	0.001020	0.003840	0.00785
0.5	0.994	3.16	0.00584	0.001020	0.003840	0.00785
0.6	0.994	3.98	0.00584	0.001020	0.003840	0.00785
0.7	0.994	5.01	0.00584	0.001020	0.003840	0.00785
0.8	0.992	6.31	0.00584	0.001020	0.003840	0.00785
0.9	0.992	7.94	0.00584	0.001020	0.003840	0.00785
1.0	0.989	10.00	0.00584	0.001030	0.003830	0.00786
1.1	0.987	12.60	0.00584	0.001030	0.003830	0.00786
1.2	0.981	15.80	0.00584	0.001030	0.003820	0.00787
1.3	0.972	20.00	0.00584	0.001040	0.003800	0.00789
1.4	0.970	25.10	0.00584	0.001030	0.003820	0.00785
1.5	0.965	31.60	0.00584	0.001030	0.003810	0.00787
1.6	0.956	39.80	0.00584	0.001040	0.003790	0.00788
1.7	0.951	50.10	0.00576	0.001030	0.003740	0.00779
1.8	0.935	63.10	0.00541	0.001010	0.003440	0.00738
1.9	0.933	79.40	0.00530	0.000992	0.003360	0.00725
2.0	0.920	100.00	0.00530	0.001010	0.003330	0.00728
2.1	0.905	126.00	0.00527	0.001010	0.003290	0.00724
2.2	0.878	158.00	0.00525	0.001020	0.003250	0.00725
2.3	0.825	200.00	0.00502	0.001020	0.003010	0.00702
2.4	0.793	251.00	0.00488	0.001000	0.002910	0.00684
2.5	0.730	316.00	0.00488	0.001070	0.002780	0.00698
2.6	0.668	398.00	0.00488	0.001090	0.002740	0.00702
2.7	0.612	501.00	0.00488	0.001130	0.002670	0.00709
2.8	0.518	631.00	0.00488	0.001230	0.002460	0.00730
2.9	0.481	794.00	0.00488	0.001370	0.002200	0.00756
3.0	0.409	1000.00	0.00488	0.001540	0.001850	0.00790
3.1	0.349	1260.00	0.00488	0.001580	0.001770	0.00798
3.2	0.278	1580.00	0.00488	0.001870	0.001210	0.00854
3.3	0.204	2000.00	0.00488	0.002220	0.000531	0.00923
3.4	0.164	2510.00	0.00468	0.002270	0.000232	0.00913
3.5	0.132	3160.00	0.00330	0.002060	-0.000725	0.00733

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00595	0.000929	0.003920	0.00797
0.1	1.26	0.995	0.00582	0.001020	0.003820	0.00782
0.2	1.58	0.995	0.00582	0.001020	0.003820	0.00782
0.3	2.00	0.995	0.00582	0.001020	0.003820	0.00782
0.4	2.51	0.994	0.00583	0.001020	0.003820	0.00783
0.5	3.16	0.994	0.00583	0.001020	0.003820	0.00783
0.6	3.98	0.994	0.00583	0.001020	0.003820	0.00783
0.7	5.01	0.994	0.00583	0.001020	0.003820	0.00783
0.8	6.31	0.992	0.00583	0.001020	0.003830	0.00784
0.9	7.94	0.992	0.00583	0.001020	0.003830	0.00784
1.0	10.00	0.989	0.00585	0.001030	0.003840	0.00787
1.1	12.60	0.987	0.00586	0.001030	0.003840	0.00788
1.2	15.80	0.981	0.00589	0.001030	0.003860	0.00791
1.3	20.00	0.972	0.00594	0.001040	0.003890	0.00798
1.4	25.10	0.970	0.00580	0.001030	0.003780	0.00782
1.5	31.60	0.965	0.00583	0.001030	0.003800	0.00785
1.6	39.80	0.956	0.00589	0.001040	0.003840	0.00793
1.7	50.10	0.951	0.00576	0.001030	0.003740	0.00779
1.8	63.10	0.935	0.00541	0.001010	0.003440	0.00738
1.9	79.40	0.933	0.00527	0.000992	0.003320	0.00721
2.0	100.00	0.920	0.00534	0.001010	0.003370	0.00732
2.1	126.00	0.905	0.00527	0.001010	0.003290	0.00724
2.2	158.00	0.878	0.00525	0.001020	0.003250	0.00725
2.3	200.00	0.825	0.00502	0.001020	0.003010	0.00702
2.4	251.00	0.793	0.00469	0.001000	0.002720	0.00665
2.5	316.00	0.730	0.00489	0.001070	0.002790	0.00699
2.6	398.00	0.668	0.00469	0.001090	0.002550	0.00684
2.7	501.00	0.612	0.00461	0.001130	0.002400	0.00682
2.8	631.00	0.518	0.00463	0.001230	0.002220	0.00705
2.9	794.00	0.481	0.00511	0.001370	0.002440	0.00779
3.0	1000.00	0.409	0.00515	0.001540	0.002130	0.00818
3.1	1260.00	0.349	0.00511	0.001580	0.002000	0.00821
3.2	1580.00	0.278	0.00529	0.001870	0.001630	0.00896
3.3	2000.00	0.204	0.00515	0.002220	0.000806	0.00950
3.4	2510.00	0.164	0.00468	0.002270	0.000232	0.00913
3.5	3160.00	0.132	0.00330	0.002060	-0.000725	0.00733

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.228	0.164	-0.09420	0.549
0.1	0.995	1.26	0.241	0.172	-0.09590	0.578
0.2	0.995	1.58	0.241	0.172	-0.09590	0.578
0.3	0.995	2.00	0.241	0.172	-0.09590	0.578
0.4	0.994	2.51	0.241	0.172	-0.09610	0.578
0.5	0.994	3.16	0.241	0.172	-0.09610	0.578
0.6	0.994	3.98	0.241	0.172	-0.09610	0.578
0.7	0.994	5.01	0.241	0.172	-0.09610	0.578
0.8	0.992	6.31	0.241	0.172	-0.09640	0.579
0.9	0.992	7.94	0.241	0.172	-0.09640	0.579
1.0	0.989	10.00	0.241	0.173	-0.09720	0.580
1.1	0.987	12.60	0.241	0.173	-0.09740	0.580
1.2	0.981	15.80	0.241	0.173	-0.09840	0.581
1.3	0.972	20.00	0.241	0.174	-0.09990	0.582
1.4	0.970	25.10	0.242	0.173	-0.09630	0.580
1.5	0.965	31.60	0.242	0.173	-0.09740	0.582
1.6	0.956	39.80	0.242	0.174	-0.09930	0.583
1.7	0.951	50.10	0.252	0.172	-0.08590	0.589
1.8	0.935	63.10	0.298	0.165	-0.02590	0.622
1.9	0.933	79.40	0.311	0.163	-0.00742	0.630
2.0	0.920	100.00	0.311	0.164	-0.01060	0.633
2.1	0.905	126.00	0.316	0.164	-0.00539	0.637
2.2	0.878	158.00	0.318	0.165	-0.00559	0.641
2.3	0.825	200.00	0.349	0.163	0.03000	0.667
2.4	0.793	251.00	0.367	0.159	0.05470	0.678
2.5	0.730	316.00	0.367	0.166	0.04040	0.693
2.6	0.668	398.00	0.367	0.169	0.03560	0.697
2.7	0.612	501.00	0.367	0.173	0.02800	0.705
2.8	0.518	631.00	0.367	0.184	0.00496	0.728
2.9	0.481	794.00	0.367	0.200	-0.02460	0.758
3.0	0.409	1000.00	0.367	0.220	-0.06520	0.798
3.1	0.349	1260.00	0.367	0.225	-0.07450	0.808
3.2	0.278	1580.00	0.367	0.259	-0.14200	0.875
3.3	0.204	2000.00	0.367	0.302	-0.22600	0.959
3.4	0.164	2510.00	0.392	0.308	-0.21100	0.995
3.5	0.132	3160.00	0.571	0.274	0.03390	1.110

IgG V1V2 AE.A244-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00597	0.000929	0.004140	0.00779
0.1	0.995	1.26	0.00597	0.001040	0.003930	0.00800
0.2	0.995	1.58	0.00597	0.001040	0.003930	0.00800
0.3	0.995	2.00	0.00597	0.001040	0.003930	0.00800
0.4	0.995	2.51	0.00597	0.001040	0.003930	0.00800
0.5	0.995	3.16	0.00597	0.001040	0.003930	0.00800
0.6	0.995	3.98	0.00597	0.001040	0.003930	0.00800
0.7	0.994	5.01	0.00597	0.001040	0.003930	0.00800
0.8	0.992	6.31	0.00597	0.001040	0.003930	0.00800
0.9	0.992	7.94	0.00584	0.001020	0.003830	0.00785
1.0	0.992	10.00	0.00584	0.001020	0.003830	0.00785
1.1	0.992	12.60	0.00584	0.001020	0.003830	0.00785
1.2	0.992	15.80	0.00584	0.001020	0.003830	0.00785
1.3	0.992	20.00	0.00584	0.001020	0.003830	0.00785
1.4	0.992	25.10	0.00584	0.001020	0.003830	0.00785
1.5	0.992	31.60	0.00584	0.001020	0.003830	0.00785
1.6	0.992	39.80	0.00584	0.001020	0.003830	0.00785
1.7	0.992	50.10	0.00584	0.001020	0.003830	0.00785
1.8	0.990	63.10	0.00584	0.001030	0.003830	0.00785
1.9	0.990	79.40	0.00584	0.001030	0.003830	0.00785
2.0	0.990	100.00	0.00584	0.001030	0.003830	0.00785
2.1	0.989	126.00	0.00584	0.001030	0.003820	0.00785
2.2	0.988	158.00	0.00572	0.001010	0.003730	0.00770
2.3	0.988	200.00	0.00572	0.001010	0.003730	0.00770
2.4	0.988	251.00	0.00572	0.001010	0.003730	0.00770
2.5	0.987	316.00	0.00572	0.001020	0.003730	0.00771
2.6	0.987	398.00	0.00572	0.001020	0.003730	0.00771
2.7	0.981	501.00	0.00572	0.001020	0.003720	0.00772
2.8	0.981	631.00	0.00560	0.001010	0.003630	0.00758
2.9	0.981	794.00	0.00560	0.001010	0.003630	0.00758
3.0	0.981	1000.00	0.00560	0.001010	0.003630	0.00758
3.1	0.979	1260.00	0.00547	0.000993	0.003520	0.00742
3.2	0.970	1580.00	0.00539	0.000990	0.003450	0.00733
3.3	0.965	2000.00	0.00526	0.000976	0.003350	0.00718
3.4	0.964	2510.00	0.00526	0.000978	0.003350	0.00718
3.5	0.950	3160.00	0.00517	0.000973	0.003260	0.00708
3.6	0.932	3980.00	0.00495	0.000958	0.003070	0.00683
3.7	0.904	5010.00	0.00481	0.000952	0.002950	0.00668
3.8	0.859	6310.00	0.00481	0.000974	0.002900	0.00672
3.9	0.804	7940.00	0.00481	0.001000	0.002850	0.00678
4.0	0.731	10000.00	0.00481	0.001060	0.002730	0.00690
4.1	0.623	12600.00	0.00481	0.001190	0.002480	0.00715
4.2	0.570	15800.00	0.00481	0.001230	0.002400	0.00723
4.3	0.472	20000.00	0.00481	0.001370	0.002120	0.00750
4.4	0.237	25100.00	0.00481	0.002230	0.000433	0.00919

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00595	0.000929	0.00392	0.00797
0.1	1.26	0.995	0.00596	0.001040	0.00393	0.00800
0.2	1.58	0.995	0.00596	0.001040	0.00393	0.00800
0.3	2.00	0.995	0.00596	0.001040	0.00393	0.00800
0.4	2.51	0.995	0.00596	0.001040	0.00393	0.00800
0.5	3.16	0.995	0.00596	0.001040	0.00393	0.00800
0.6	3.98	0.995	0.00596	0.001040	0.00393	0.00800
0.7	5.01	0.994	0.00597	0.001040	0.00394	0.00801
0.8	6.31	0.992	0.00598	0.001040	0.00394	0.00802
0.9	7.94	0.992	0.00583	0.001020	0.00383	0.00784
1.0	10.00	0.992	0.00583	0.001020	0.00383	0.00784
1.1	12.60	0.992	0.00583	0.001020	0.00383	0.00784
1.2	15.80	0.992	0.00583	0.001020	0.00383	0.00784
1.3	20.00	0.992	0.00583	0.001020	0.00383	0.00784
1.4	25.10	0.992	0.00583	0.001020	0.00383	0.00784
1.5	31.60	0.992	0.00583	0.001020	0.00383	0.00784
1.6	39.80	0.992	0.00583	0.001020	0.00383	0.00784
1.7	50.10	0.992	0.00583	0.001020	0.00383	0.00784
1.8	63.10	0.990	0.00584	0.001030	0.00383	0.00785
1.9	79.40	0.990	0.00584	0.001030	0.00383	0.00785
2.0	100.00	0.990	0.00584	0.001030	0.00383	0.00785
2.1	126.00	0.989	0.00585	0.001030	0.00384	0.00787
2.2	158.00	0.988	0.00570	0.001010	0.00372	0.00769
2.3	200.00	0.988	0.00570	0.001010	0.00372	0.00769
2.4	251.00	0.988	0.00570	0.001010	0.00372	0.00769
2.5	316.00	0.987	0.00572	0.001020	0.00373	0.00771
2.6	398.00	0.987	0.00572	0.001020	0.00373	0.00771
2.7	501.00	0.981	0.00575	0.001020	0.00374	0.00775
2.8	631.00	0.981	0.00560	0.001010	0.00363	0.00758
2.9	794.00	0.981	0.00560	0.001010	0.00363	0.00758
3.0	1000.00	0.981	0.00560	0.001010	0.00363	0.00758
3.1	1260.00	0.979	0.00547	0.000993	0.00352	0.00742
3.2	1580.00	0.970	0.00539	0.000990	0.00345	0.00733
3.3	2000.00	0.965	0.00526	0.000976	0.00334	0.00717
3.4	2510.00	0.964	0.00527	0.000978	0.00335	0.00718
3.5	3160.00	0.950	0.00517	0.000973	0.00326	0.00708
3.6	3980.00	0.932	0.00495	0.000958	0.00307	0.00683
3.7	5010.00	0.904	0.00477	0.000952	0.00291	0.00664
3.8	6310.00	0.859	0.00472	0.000974	0.00281	0.00663
3.9	7940.00	0.804	0.00468	0.001000	0.00272	0.00664
4.0	10000.00	0.731	0.00477	0.001060	0.00268	0.00685
4.1	12600.00	0.623	0.00496	0.001190	0.00262	0.00730
4.2	15800.00	0.570	0.00489	0.001230	0.00248	0.00731
4.3	20000.00	0.472	0.00495	0.001370	0.00226	0.00764
4.4	25100.00	0.237	0.00565	0.002230	0.00127	0.01000

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.225	0.164	-0.09680	0.548
0.1	0.995	1.26	0.225	0.175	-0.11700	0.568
0.2	0.995	1.58	0.225	0.175	-0.11700	0.568
0.3	0.995	2.00	0.225	0.175	-0.11700	0.568
0.4	0.995	2.51	0.225	0.175	-0.11700	0.568
0.5	0.995	3.16	0.225	0.175	-0.11700	0.568
0.6	0.995	3.98	0.225	0.175	-0.11700	0.568
0.7	0.994	5.01	0.225	0.175	-0.11800	0.568
0.8	0.992	6.31	0.225	0.175	-0.11800	0.569
0.9	0.992	7.94	0.242	0.172	-0.09550	0.579
1.0	0.992	10.00	0.242	0.172	-0.09550	0.579
1.1	0.992	12.60	0.242	0.172	-0.09550	0.579
1.2	0.992	15.80	0.242	0.172	-0.09550	0.579
1.3	0.992	20.00	0.242	0.172	-0.09550	0.579
1.4	0.992	25.10	0.242	0.172	-0.09550	0.579
1.5	0.992	31.60	0.242	0.172	-0.09550	0.579
1.6	0.992	39.80	0.242	0.172	-0.09550	0.579
1.7	0.992	50.10	0.242	0.172	-0.09550	0.579
1.8	0.990	63.10	0.242	0.172	-0.09580	0.580
1.9	0.990	79.40	0.242	0.172	-0.09580	0.580
2.0	0.990	100.00	0.242	0.172	-0.09580	0.580
2.1	0.989	126.00	0.242	0.173	-0.09620	0.580
2.2	0.988	158.00	0.258	0.170	-0.07460	0.590
2.3	0.988	200.00	0.258	0.170	-0.07460	0.590
2.4	0.988	251.00	0.258	0.170	-0.07460	0.590
2.5	0.987	316.00	0.258	0.170	-0.07510	0.591
2.6	0.987	398.00	0.258	0.170	-0.07510	0.591
2.7	0.981	501.00	0.258	0.170	-0.07620	0.592
2.8	0.981	631.00	0.272	0.168	-0.05600	0.601
2.9	0.981	794.00	0.272	0.168	-0.05600	0.601
3.0	0.981	1000.00	0.272	0.168	-0.05600	0.601
3.1	0.979	1260.00	0.290	0.165	-0.03310	0.613
3.2	0.970	1580.00	0.300	0.163	-0.02010	0.620
3.3	0.965	2000.00	0.317	0.161	0.00200	0.631
3.4	0.964	2510.00	0.317	0.161	0.00166	0.632
3.5	0.950	3160.00	0.328	0.159	0.01640	0.641
3.6	0.932	3980.00	0.357	0.155	0.05290	0.661
3.7	0.904	5010.00	0.375	0.153	0.07540	0.675
3.8	0.859	6310.00	0.375	0.155	0.07070	0.680
3.9	0.804	7940.00	0.375	0.158	0.06500	0.685
4.0	0.731	10000.00	0.375	0.165	0.05190	0.698
4.1	0.623	12600.00	0.375	0.179	0.02400	0.726
4.2	0.570	15800.00	0.375	0.184	0.01520	0.735
4.3	0.472	20000.00	0.375	0.200	-0.01610	0.766
4.4	0.237	25100.00	0.375	0.304	-0.22000	0.971

IgG V1V2 C.1086-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00595	0.000929	0.004130	0.00777
0.1	0.995	1.26	0.00584	0.001020	0.003840	0.00784
0.2	0.994	1.58	0.00584	0.001020	0.003830	0.00785
0.3	0.994	2.00	0.00584	0.001020	0.003830	0.00785
0.4	0.992	2.51	0.00584	0.001020	0.003830	0.00785
0.5	0.992	3.16	0.00584	0.001020	0.003830	0.00785
0.6	0.992	3.98	0.00584	0.001020	0.003830	0.00785
0.7	0.992	5.01	0.00584	0.001020	0.003830	0.00785
0.8	0.992	6.31	0.00584	0.001020	0.003830	0.00785
0.9	0.992	7.94	0.00584	0.001020	0.003830	0.00785
1.0	0.992	10.00	0.00584	0.001020	0.003830	0.00785
1.1	0.992	12.60	0.00584	0.001020	0.003830	0.00785
1.2	0.992	15.80	0.00584	0.001020	0.003830	0.00785
1.3	0.990	20.00	0.00584	0.001030	0.003830	0.00785
1.4	0.990	25.10	0.00584	0.001030	0.003830	0.00785
1.5	0.989	31.60	0.00584	0.001030	0.003820	0.00786
1.6	0.987	39.80	0.00584	0.001030	0.003820	0.00786
1.7	0.987	50.10	0.00584	0.001030	0.003820	0.00786
1.8	0.987	63.10	0.00584	0.001030	0.003820	0.00786
1.9	0.981	79.40	0.00575	0.001020	0.003740	0.00775
2.0	0.981	100.00	0.00575	0.001020	0.003740	0.00775
2.1	0.981	126.00	0.00575	0.001020	0.003740	0.00775
2.2	0.981	158.00	0.00560	0.001010	0.003630	0.00758
2.3	0.981	200.00	0.00560	0.001010	0.003630	0.00758
2.4	0.981	251.00	0.00560	0.001010	0.003630	0.00758
2.5	0.961	316.00	0.00558	0.001010	0.003590	0.00756
2.6	0.955	398.00	0.00545	0.001000	0.003490	0.00742
2.7	0.955	501.00	0.00530	0.000985	0.003370	0.00723
2.8	0.950	631.00	0.00517	0.000973	0.003260	0.00707
2.9	0.950	794.00	0.00494	0.000940	0.003090	0.00678
3.0	0.940	1000.00	0.00494	0.000948	0.003080	0.00679
3.1	0.909	1260.00	0.00494	0.000977	0.003020	0.00685
3.2	0.852	1580.00	0.00491	0.000992	0.002970	0.00686
3.3	0.794	2000.00	0.00491	0.001040	0.002870	0.00696
3.4	0.736	2510.00	0.00490	0.001070	0.002800	0.00701
3.5	0.634	3160.00	0.00489	0.001120	0.002690	0.00708
3.6	0.554	3980.00	0.00489	0.001210	0.002520	0.00725
3.7	0.466	5010.00	0.00489	0.001340	0.002250	0.00752
3.8	0.386	6310.00	0.00489	0.001600	0.001760	0.00802
3.9	0.281	7940.00	0.00489	0.001890	0.001180	0.00860
4.0	0.198	10000.00	0.00489	0.002100	0.000777	0.00900
4.1	0.158	12600.00	0.00489	0.002370	0.000243	0.00953
4.2	0.116	15800.00	0.00324	0.002010	-0.000699	0.00718

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00595	0.000929	0.003920	0.00797
0.1	1.26	0.995	0.00582	0.001020	0.003820	0.00782
0.2	1.58	0.994	0.00583	0.001020	0.003820	0.00783
0.3	2.00	0.994	0.00583	0.001020	0.003820	0.00783
0.4	2.51	0.992	0.00583	0.001020	0.003830	0.00784
0.5	3.16	0.992	0.00583	0.001020	0.003830	0.00784
0.6	3.98	0.992	0.00583	0.001020	0.003830	0.00784
0.7	5.01	0.992	0.00583	0.001020	0.003830	0.00784
0.8	6.31	0.992	0.00583	0.001020	0.003830	0.00784
0.9	7.94	0.992	0.00583	0.001020	0.003830	0.00784
1.0	10.00	0.992	0.00583	0.001020	0.003830	0.00784
1.1	12.60	0.992	0.00583	0.001020	0.003830	0.00784
1.2	15.80	0.992	0.00583	0.001020	0.003830	0.00784
1.3	20.00	0.990	0.00584	0.001030	0.003830	0.00785
1.4	25.10	0.990	0.00584	0.001030	0.003830	0.00785
1.5	31.60	0.989	0.00586	0.001030	0.003840	0.00787
1.6	39.80	0.987	0.00586	0.001030	0.003850	0.00788
1.7	50.10	0.987	0.00586	0.001030	0.003850	0.00788
1.8	63.10	0.987	0.00586	0.001030	0.003850	0.00788
1.9	79.40	0.981	0.00575	0.001020	0.003740	0.00775
2.0	100.00	0.981	0.00575	0.001020	0.003740	0.00775
2.1	126.00	0.981	0.00575	0.001020	0.003740	0.00775
2.2	158.00	0.981	0.00560	0.001010	0.003630	0.00758
2.3	200.00	0.981	0.00560	0.001010	0.003630	0.00758
2.4	251.00	0.981	0.00560	0.001010	0.003630	0.00758
2.5	316.00	0.961	0.00558	0.001010	0.003590	0.00756
2.6	398.00	0.955	0.00545	0.001000	0.003490	0.00742
2.7	501.00	0.955	0.00530	0.000985	0.003370	0.00723
2.8	631.00	0.950	0.00517	0.000973	0.003260	0.00707
2.9	794.00	0.950	0.00487	0.000940	0.003020	0.00671
3.0	1000.00	0.940	0.00491	0.000948	0.003050	0.00676
3.1	1260.00	0.909	0.00504	0.000977	0.003130	0.00695
3.2	1580.00	0.852	0.00489	0.000992	0.002940	0.00683
3.3	2000.00	0.794	0.00494	0.001040	0.002900	0.00699
3.4	2510.00	0.736	0.00490	0.001070	0.002800	0.00701
3.5	3160.00	0.634	0.00458	0.001120	0.002390	0.00677
3.6	3980.00	0.554	0.00467	0.001210	0.002300	0.00703
3.7	5010.00	0.466	0.00475	0.001340	0.002110	0.00738
3.8	6310.00	0.386	0.00530	0.001600	0.002170	0.00843
3.9	7940.00	0.281	0.00534	0.001890	0.001630	0.00905
4.0	10000.00	0.198	0.00492	0.002100	0.000811	0.00903
4.1	12600.00	0.158	0.00509	0.002370	0.000446	0.00974
4.2	15800.00	0.116	0.00324	0.002010	-0.000699	0.00718

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.228	0.164	-0.09420	0.549
0.1	0.995	1.26	0.242	0.172	-0.09530	0.579
0.2	0.994	1.58	0.242	0.172	-0.09560	0.579
0.3	0.994	2.00	0.242	0.172	-0.09560	0.579
0.4	0.992	2.51	0.242	0.172	-0.09580	0.579
0.5	0.992	3.16	0.242	0.172	-0.09580	0.579
0.6	0.992	3.98	0.242	0.172	-0.09580	0.579
0.7	0.992	5.01	0.242	0.172	-0.09580	0.579
0.8	0.992	6.31	0.242	0.172	-0.09580	0.579
0.9	0.992	7.94	0.242	0.172	-0.09580	0.579
1.0	0.992	10.00	0.242	0.172	-0.09580	0.579
1.1	0.992	12.60	0.242	0.172	-0.09580	0.579
1.2	0.992	15.80	0.242	0.172	-0.09580	0.579
1.3	0.990	20.00	0.242	0.172	-0.09620	0.580
1.4	0.990	25.10	0.242	0.172	-0.09620	0.580
1.5	0.989	31.60	0.242	0.173	-0.09670	0.580
1.6	0.987	39.80	0.242	0.173	-0.09700	0.580
1.7	0.987	50.10	0.242	0.173	-0.09700	0.580
1.8	0.987	63.10	0.242	0.173	-0.09700	0.580
1.9	0.981	79.40	0.254	0.171	-0.08070	0.589
2.0	0.981	100.00	0.254	0.171	-0.08070	0.589
2.1	0.981	126.00	0.254	0.171	-0.08070	0.589
2.2	0.981	158.00	0.272	0.168	-0.05600	0.601
2.3	0.981	200.00	0.272	0.168	-0.05600	0.601
2.4	0.981	251.00	0.272	0.168	-0.05600	0.601
2.5	0.961	316.00	0.276	0.168	-0.05330	0.605
2.6	0.955	398.00	0.292	0.165	-0.03230	0.616
2.7	0.955	501.00	0.311	0.162	-0.00594	0.629
2.8	0.950	631.00	0.329	0.159	0.01700	0.641
2.9	0.950	794.00	0.359	0.153	0.05900	0.659
3.0	0.940	1000.00	0.359	0.154	0.05730	0.661
3.1	0.909	1260.00	0.359	0.157	0.05140	0.667
3.2	0.852	1580.00	0.362	0.158	0.05150	0.672
3.3	0.794	2000.00	0.362	0.164	0.04090	0.683
3.4	0.736	2510.00	0.363	0.167	0.03600	0.691
3.5	0.634	3160.00	0.365	0.172	0.02870	0.702
3.6	0.554	3980.00	0.365	0.181	0.00969	0.721
3.7	0.466	5010.00	0.365	0.197	-0.02100	0.752
3.8	0.386	6310.00	0.365	0.227	-0.07870	0.809
3.9	0.281	7940.00	0.365	0.262	-0.14900	0.880
4.0	0.198	10000.00	0.365	0.287	-0.19800	0.928
4.1	0.158	12600.00	0.365	0.321	-0.26400	0.995
4.2	0.116	15800.00	0.579	0.268	0.05420	1.100

IgG V1V2 C.1086-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00597	0.000929	0.00415	0.00779
0.1	0.9950	1.26	0.00597	0.001040	0.00394	0.00800
0.2	0.9950	1.58	0.00597	0.001040	0.00394	0.00800
0.3	0.9950	2.00	0.00597	0.001040	0.00394	0.00800
0.4	0.9940	2.51	0.00597	0.001040	0.00393	0.00800
0.5	0.9920	3.16	0.00597	0.001040	0.00393	0.00800
0.6	0.9920	3.98	0.00597	0.001040	0.00393	0.00800
0.7	0.9920	5.01	0.00584	0.001020	0.00383	0.00785
0.8	0.9920	6.31	0.00584	0.001020	0.00383	0.00785
0.9	0.9920	7.94	0.00584	0.001020	0.00383	0.00785
1.0	0.9920	10.00	0.00584	0.001020	0.00383	0.00785
1.1	0.9900	12.60	0.00584	0.001030	0.00383	0.00785
1.2	0.9900	15.80	0.00584	0.001030	0.00383	0.00785
1.3	0.9900	20.00	0.00584	0.001030	0.00383	0.00785
1.4	0.9900	25.10	0.00584	0.001030	0.00383	0.00785
1.5	0.9900	31.60	0.00584	0.001030	0.00383	0.00785
1.6	0.9900	39.80	0.00584	0.001030	0.00383	0.00785
1.7	0.9900	50.10	0.00584	0.001030	0.00383	0.00785
1.8	0.9900	63.10	0.00584	0.001030	0.00383	0.00785
1.9	0.9890	79.40	0.00584	0.001030	0.00382	0.00786
2.0	0.9880	100.00	0.00573	0.001010	0.00374	0.00771
2.1	0.9870	126.00	0.00573	0.001020	0.00374	0.00772
2.2	0.9870	158.00	0.00573	0.001020	0.00374	0.00772
2.3	0.9870	200.00	0.00573	0.001020	0.00374	0.00772
2.4	0.9870	251.00	0.00573	0.001020	0.00374	0.00772
2.5	0.9810	316.00	0.00573	0.001020	0.00372	0.00773
2.6	0.9810	398.00	0.00573	0.001020	0.00372	0.00773
2.7	0.9810	501.00	0.00562	0.001010	0.00365	0.00759
2.8	0.9760	631.00	0.00562	0.001010	0.00364	0.00760
2.9	0.9670	794.00	0.00540	0.000990	0.00346	0.00735
3.0	0.9670	1000.00	0.00540	0.000990	0.00346	0.00735
3.1	0.9630	1260.00	0.00540	0.000994	0.00346	0.00735
3.2	0.9520	1580.00	0.00531	0.000988	0.00338	0.00725
3.3	0.9370	2000.00	0.00527	0.000951	0.00341	0.00714
3.4	0.9160	2510.00	0.00527	0.000961	0.00339	0.00716
3.5	0.8940	3160.00	0.00527	0.000984	0.00334	0.00720
3.6	0.8580	3980.00	0.00527	0.001010	0.00329	0.00725
3.7	0.7630	5010.00	0.00527	0.001110	0.00309	0.00746
3.8	0.6750	6310.00	0.00527	0.001170	0.00298	0.00756
3.9	0.5820	7940.00	0.00527	0.001360	0.00261	0.00793
4.0	0.4960	10000.00	0.00527	0.001540	0.00226	0.00829
4.1	0.4170	12600.00	0.00500	0.001430	0.00220	0.00780
4.2	0.3270	15800.00	0.00500	0.001710	0.00165	0.00835
4.3	0.2430	20000.00	0.00500	0.001950	0.00117	0.00883
4.4	0.0777	25100.00	0.00500	0.004890	-0.00459	0.01460

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00595	0.000929	0.00392	0.00797
0.1	1.26	0.9950	0.00596	0.001040	0.00393	0.00800
0.2	1.58	0.9950	0.00596	0.001040	0.00393	0.00800
0.3	2.00	0.9950	0.00596	0.001040	0.00393	0.00800
0.4	2.51	0.9940	0.00597	0.001040	0.00394	0.00801
0.5	3.16	0.9920	0.00598	0.001040	0.00394	0.00802
0.6	3.98	0.9920	0.00598	0.001040	0.00394	0.00802
0.7	5.01	0.9920	0.00583	0.001020	0.00383	0.00784
0.8	6.31	0.9920	0.00583	0.001020	0.00383	0.00784
0.9	7.94	0.9920	0.00583	0.001020	0.00383	0.00784
1.0	10.00	0.9920	0.00583	0.001020	0.00383	0.00784
1.1	12.60	0.9900	0.00584	0.001030	0.00383	0.00785
1.2	15.80	0.9900	0.00584	0.001030	0.00383	0.00785
1.3	20.00	0.9900	0.00584	0.001030	0.00383	0.00785
1.4	25.10	0.9900	0.00584	0.001030	0.00383	0.00785
1.5	31.60	0.9900	0.00584	0.001030	0.00383	0.00785
1.6	39.80	0.9900	0.00584	0.001030	0.00383	0.00785
1.7	50.10	0.9900	0.00584	0.001030	0.00383	0.00785
1.8	63.10	0.9900	0.00584	0.001030	0.00383	0.00785
1.9	79.40	0.9890	0.00586	0.001030	0.00384	0.00787
2.0	100.00	0.9880	0.00571	0.001010	0.00372	0.00770
2.1	126.00	0.9870	0.00572	0.001020	0.00373	0.00771
2.2	158.00	0.9870	0.00572	0.001020	0.00373	0.00771
2.3	200.00	0.9870	0.00572	0.001020	0.00373	0.00771
2.4	251.00	0.9870	0.00572	0.001020	0.00373	0.00771
2.5	316.00	0.9810	0.00575	0.001020	0.00374	0.00775
2.6	398.00	0.9810	0.00575	0.001020	0.00374	0.00775
2.7	501.00	0.9810	0.00560	0.001010	0.00363	0.00758
2.8	631.00	0.9760	0.00564	0.001010	0.00366	0.00762
2.9	794.00	0.9670	0.00540	0.000990	0.00346	0.00734
3.0	1000.00	0.9670	0.00540	0.000990	0.00346	0.00734
3.1	1260.00	0.9630	0.00542	0.000994	0.00347	0.00737
3.2	1580.00	0.9520	0.00531	0.000988	0.00338	0.00725
3.3	2000.00	0.9370	0.00492	0.000951	0.00306	0.00678
3.4	2510.00	0.9160	0.00489	0.000961	0.00301	0.00678
3.5	3160.00	0.8940	0.00500	0.000984	0.00307	0.00693
3.6	3980.00	0.8580	0.00504	0.001010	0.00306	0.00702
3.7	5010.00	0.7630	0.00534	0.001110	0.00316	0.00753
3.8	6310.00	0.6750	0.00530	0.001170	0.00301	0.00760
3.9	7940.00	0.5820	0.00585	0.001360	0.00319	0.00851
4.0	10000.00	0.4960	0.00615	0.001540	0.00313	0.00916
4.1	12600.00	0.4170	0.00471	0.001430	0.00191	0.00751
4.2	15800.00	0.3270	0.00532	0.001710	0.00197	0.00867
4.3	20000.00	0.2430	0.00528	0.001950	0.00146	0.00911
4.4	25100.00	0.0777	0.00646	0.004890	-0.00313	0.01610

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.225	0.164	-0.097100	0.547
0.1	0.9950	1.26	0.225	0.175	-0.118000	0.568
0.2	0.9950	1.58	0.225	0.175	-0.118000	0.568
0.3	0.9950	2.00	0.225	0.175	-0.118000	0.568
0.4	0.9940	2.51	0.225	0.175	-0.118000	0.568
0.5	0.9920	3.16	0.225	0.175	-0.118000	0.569
0.6	0.9920	3.98	0.225	0.175	-0.118000	0.569
0.7	0.9920	5.01	0.242	0.172	-0.096000	0.579
0.8	0.9920	6.31	0.242	0.172	-0.096000	0.579
0.9	0.9920	7.94	0.242	0.172	-0.096000	0.579
1.0	0.9920	10.00	0.242	0.172	-0.096000	0.579
1.1	0.9900	12.60	0.242	0.172	-0.096300	0.579
1.2	0.9900	15.80	0.242	0.172	-0.096300	0.579
1.3	0.9900	20.00	0.242	0.172	-0.096300	0.579
1.4	0.9900	25.10	0.242	0.172	-0.096300	0.579
1.5	0.9900	31.60	0.242	0.172	-0.096300	0.579
1.6	0.9900	39.80	0.242	0.172	-0.096300	0.579
1.7	0.9900	50.10	0.242	0.172	-0.096300	0.579
1.8	0.9900	63.10	0.242	0.172	-0.096300	0.579
1.9	0.9890	79.40	0.242	0.173	-0.096900	0.580
2.0	0.9880	100.00	0.257	0.170	-0.076100	0.589
2.1	0.9870	126.00	0.257	0.170	-0.076500	0.590
2.2	0.9870	158.00	0.257	0.170	-0.076500	0.590
2.3	0.9870	200.00	0.257	0.170	-0.076500	0.590
2.4	0.9870	251.00	0.257	0.170	-0.076500	0.590
2.5	0.9810	316.00	0.257	0.170	-0.077600	0.591
2.6	0.9810	398.00	0.257	0.170	-0.077600	0.591
2.7	0.9810	501.00	0.270	0.168	-0.058700	0.599
2.8	0.9760	631.00	0.270	0.168	-0.059600	0.600
2.9	0.9670	794.00	0.298	0.164	-0.022500	0.619
3.0	0.9670	1000.00	0.298	0.164	-0.022500	0.619
3.1	0.9630	1260.00	0.298	0.164	-0.023300	0.620
3.2	0.9520	1580.00	0.310	0.162	-0.008270	0.628
3.3	0.9370	2000.00	0.315	0.158	0.005630	0.625
3.4	0.9160	2510.00	0.315	0.159	0.003590	0.627
3.5	0.8940	3160.00	0.315	0.161	-0.000982	0.632
3.6	0.8580	3980.00	0.315	0.164	-0.006340	0.637
3.7	0.7630	5010.00	0.315	0.175	-0.027800	0.659
3.8	0.6750	6310.00	0.315	0.181	-0.039600	0.671
3.9	0.5820	7940.00	0.315	0.202	-0.080400	0.711
4.0	0.4960	10000.00	0.315	0.223	-0.121000	0.752
4.1	0.4170	12600.00	0.351	0.208	-0.056200	0.758
4.2	0.3270	15800.00	0.351	0.241	-0.121000	0.823
4.3	0.2430	20000.00	0.351	0.270	-0.179000	0.880
4.4	0.0777	25100.00	0.351	0.642	-0.908000	1.610

IgG3 V1V2 B.CaseA-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00595	0.000929	0.004130	0.00777
0.1	0.9800	1.26	0.00558	0.000993	0.003630	0.00753
0.2	0.9760	1.58	0.00558	0.000996	0.003630	0.00753
0.3	0.9760	2.00	0.00558	0.000996	0.003630	0.00753
0.4	0.9510	2.51	0.00558	0.001010	0.003600	0.00755
0.5	0.9510	3.16	0.00558	0.001010	0.003600	0.00755
0.6	0.9330	3.98	0.00558	0.001030	0.003560	0.00759
0.7	0.9210	5.01	0.00558	0.001040	0.003540	0.00762
0.8	0.9210	6.31	0.00558	0.001040	0.003540	0.00762
0.9	0.9120	7.94	0.00558	0.001040	0.003550	0.00761
1.0	0.8790	10.00	0.00558	0.001070	0.003470	0.00769
1.1	0.8220	12.60	0.00558	0.001090	0.003450	0.00771
1.2	0.7910	15.80	0.00558	0.001120	0.003390	0.00777
1.3	0.7510	20.00	0.00558	0.001160	0.003310	0.00784
1.4	0.7170	25.10	0.00558	0.001180	0.003270	0.00789
1.5	0.6690	31.60	0.00545	0.001190	0.003110	0.00778
1.6	0.6180	39.80	0.00545	0.001230	0.003040	0.00786
1.7	0.5140	50.10	0.00545	0.001410	0.002690	0.00821
1.8	0.4730	63.10	0.00545	0.001460	0.002580	0.00831
1.9	0.4040	79.40	0.00512	0.001440	0.002300	0.00793
2.0	0.3280	100.00	0.00512	0.001500	0.002170	0.00807
2.1	0.2790	126.00	0.00512	0.001780	0.001630	0.00861
2.2	0.2230	158.00	0.00512	0.002320	0.000566	0.00967
2.3	0.1990	200.00	0.00512	0.002340	0.000531	0.00971
2.4	0.1570	251.00	0.00512	0.002980	-0.000724	0.01100
2.5	0.1290	316.00	0.00512	0.003390	-0.001530	0.01180
2.6	0.0959	398.00	0.00512	0.002770	-0.000314	0.01060
2.7	0.0761	501.00	0.00512	0.003640	-0.002010	0.01220
2.8	0.0512	631.00	0.00512	0.006910	-0.008430	0.01870
2.9	0.0455	794.00	0.00512	0.009340	-0.013200	0.02340
3.0	0.0340	1000.00	0.00512	0.007420	-0.009430	0.01970
3.1	0.0239	1260.00	0.00512	0.007110	-0.008820	0.01910
3.2	0.0239	1580.00	0.00512	0.007110	-0.008820	0.01910
3.3	0.0239	2000.00	0.00512	0.007110	-0.008820	0.01910

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00595	0.000929	0.003920	0.00797
0.1	1.26	0.9800	0.00548	0.000993	0.003530	0.00743
0.2	1.58	0.9760	0.00550	0.000996	0.003550	0.00745
0.3	2.00	0.9760	0.00550	0.000996	0.003550	0.00745
0.4	2.51	0.9510	0.00549	0.001010	0.003510	0.00746
0.5	3.16	0.9510	0.00549	0.001010	0.003510	0.00746
0.6	3.98	0.9330	0.00559	0.001030	0.003580	0.00761
0.7	5.01	0.9210	0.00566	0.001040	0.003620	0.00770
0.8	6.31	0.9210	0.00566	0.001040	0.003620	0.00770
0.9	7.94	0.9120	0.00556	0.001040	0.003530	0.00759
1.0	10.00	0.8790	0.00575	0.001070	0.003640	0.00785
1.1	12.60	0.8220	0.00556	0.001090	0.003430	0.00769
1.2	15.80	0.7910	0.00560	0.001120	0.003420	0.00779
1.3	20.00	0.7510	0.00570	0.001160	0.003430	0.00796
1.4	25.10	0.7170	0.00562	0.001180	0.003300	0.00793
1.5	31.60	0.6690	0.00537	0.001190	0.003040	0.00771
1.6	39.80	0.6180	0.00522	0.001230	0.002810	0.00763
1.7	50.10	0.5140	0.00566	0.001410	0.002900	0.00842
1.8	63.10	0.4730	0.00557	0.001460	0.002700	0.00843
1.9	79.40	0.4040	0.00473	0.001440	0.001910	0.00754
2.0	100.00	0.3280	0.00434	0.001500	0.001390	0.00729
2.1	126.00	0.2790	0.00510	0.001780	0.001610	0.00858
2.2	158.00	0.2230	0.00650	0.002320	0.001950	0.01110
2.3	200.00	0.1990	0.00591	0.002340	0.001320	0.01050
2.4	251.00	0.1570	0.00677	0.002980	0.000927	0.01260
2.5	316.00	0.1290	0.00646	0.003390	-0.000196	0.01310
2.6	398.00	0.0959	0.00476	0.002770	-0.000669	0.01020
2.7	501.00	0.0761	0.00523	0.003640	-0.001890	0.01240
2.8	631.00	0.0512	0.00766	0.006910	-0.005890	0.02120
2.9	794.00	0.0455	0.01030	0.009340	-0.007990	0.02860
3.0	1000.00	0.0340	0.01030	0.007420	-0.004250	0.02480
3.1	1260.00	0.0239	0.01570	0.007110	0.001720	0.02960
3.2	1580.00	0.0239	0.01570	0.007110	0.001720	0.02960
3.3	2000.00	0.0239	0.01570	0.007110	0.001720	0.02960

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.228	0.164	-0.0942	0.549
0.1	0.9800	1.26	0.276	0.166	-0.0497	0.601
0.2	0.9760	1.58	0.276	0.166	-0.0503	0.601
0.3	0.9760	2.00	0.276	0.166	-0.0503	0.601
0.4	0.9510	2.51	0.276	0.167	-0.0526	0.604
0.5	0.9510	3.16	0.276	0.167	-0.0526	0.604
0.6	0.9330	3.98	0.276	0.170	-0.0568	0.608
0.7	0.9210	5.01	0.276	0.171	-0.0593	0.610
0.8	0.9210	6.31	0.276	0.171	-0.0593	0.610
0.9	0.9120	7.94	0.276	0.170	-0.0583	0.609
1.0	0.8790	10.00	0.276	0.174	-0.0661	0.617
1.1	0.8220	12.60	0.276	0.176	-0.0685	0.620
1.2	0.7910	15.80	0.276	0.179	-0.0747	0.626
1.3	0.7510	20.00	0.276	0.183	-0.0829	0.634
1.4	0.7170	25.10	0.276	0.185	-0.0880	0.639
1.5	0.6690	31.60	0.293	0.185	-0.0705	0.656
1.6	0.6180	39.80	0.293	0.190	-0.0789	0.664
1.7	0.5140	50.10	0.293	0.209	-0.1180	0.703
1.8	0.4730	63.10	0.293	0.215	-0.1300	0.715
1.9	0.4040	79.40	0.335	0.210	-0.0757	0.746
2.0	0.3280	100.00	0.335	0.218	-0.0912	0.762
2.1	0.2790	126.00	0.335	0.250	-0.1550	0.825
2.2	0.2230	158.00	0.335	0.317	-0.2850	0.956
2.3	0.1990	200.00	0.335	0.319	-0.2890	0.960
2.4	0.1570	251.00	0.335	0.399	-0.4460	1.120
2.5	0.1290	316.00	0.335	0.451	-0.5490	1.220
2.6	0.0959	398.00	0.335	0.372	-0.3950	1.070
2.7	0.0761	501.00	0.335	0.482	-0.6090	1.280
2.8	0.0512	631.00	0.335	0.903	-1.4300	2.110
2.9	0.0455	794.00	0.335	1.220	-2.0500	2.720
3.0	0.0340	1000.00	0.335	0.968	-1.5600	2.230
3.1	0.0239	1260.00	0.335	0.928	-1.4800	2.150
3.2	0.0239	1580.00	0.335	0.928	-1.4800	2.150
3.3	0.0239	2000.00	0.335	0.928	-1.4800	2.150

IgG3 V1V2 AE.A244-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00595	0.000929	0.004130	0.00777
0.1	0.9880	1.26	0.00585	0.001030	0.003840	0.00787
0.2	0.9880	1.58	0.00585	0.001030	0.003840	0.00787
0.3	0.9880	2.00	0.00585	0.001030	0.003840	0.00787
0.4	0.9880	2.51	0.00585	0.001030	0.003840	0.00787
0.5	0.9880	3.16	0.00585	0.001030	0.003840	0.00787
0.6	0.9880	3.98	0.00585	0.001030	0.003840	0.00787
0.7	0.9860	5.01	0.00585	0.001030	0.003840	0.00787
0.8	0.9860	6.31	0.00574	0.001010	0.003750	0.00773
0.9	0.9820	7.94	0.00574	0.001020	0.003750	0.00773
1.0	0.9820	10.00	0.00574	0.001020	0.003750	0.00773
1.1	0.9800	12.60	0.00574	0.001020	0.003750	0.00774
1.2	0.9780	15.80	0.00574	0.001020	0.003740	0.00774
1.3	0.9720	20.00	0.00574	0.001030	0.003730	0.00775
1.4	0.9700	25.10	0.00568	0.001010	0.003690	0.00766
1.5	0.9660	31.60	0.00568	0.001020	0.003680	0.00767
1.6	0.9660	39.80	0.00568	0.001020	0.003680	0.00767
1.7	0.9590	50.10	0.00568	0.001020	0.003670	0.00768
1.8	0.9500	63.10	0.00563	0.001020	0.003640	0.00763
1.9	0.9410	79.40	0.00563	0.001030	0.003620	0.00765
2.0	0.9300	100.00	0.00559	0.001030	0.003570	0.00760
2.1	0.9300	126.00	0.00546	0.001010	0.003480	0.00744
2.2	0.9170	158.00	0.00546	0.001020	0.003450	0.00747
2.3	0.8940	200.00	0.00535	0.001010	0.003370	0.00733
2.4	0.8530	251.00	0.00535	0.001040	0.003310	0.00739
2.5	0.8170	316.00	0.00535	0.001060	0.003270	0.00743
2.6	0.7530	398.00	0.00535	0.001110	0.003170	0.00753
2.7	0.7070	501.00	0.00520	0.001110	0.003020	0.00738
2.8	0.6480	631.00	0.00520	0.001150	0.002940	0.00746
2.9	0.5840	794.00	0.00520	0.001180	0.002880	0.00752
3.0	0.4820	1000.00	0.00520	0.001400	0.002450	0.00795
3.1	0.4010	1260.00	0.00520	0.001510	0.002230	0.00817
3.2	0.3360	1580.00	0.00520	0.001690	0.001890	0.00851
3.3	0.2710	2000.00	0.00520	0.002020	0.001240	0.00916
3.4	0.2050	2510.00	0.00520	0.002570	0.000160	0.01020
3.5	0.1730	3160.00	0.00520	0.002870	-0.000418	0.01080
3.6	0.1310	3980.00	0.00520	0.003200	-0.001060	0.01150
3.7	0.1110	5010.00	0.00520	0.003760	-0.002170	0.01260
3.8	0.0759	6310.00	0.00520	0.003860	-0.002370	0.01280
3.9	0.0645	7940.00	0.00520	0.005640	-0.005860	0.01630

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00595	0.000929	3.92e-03	0.00797
0.1	1.26	0.9880	0.00585	0.001030	3.84e-03	0.00787
0.2	1.58	0.9880	0.00585	0.001030	3.84e-03	0.00787
0.3	2.00	0.9880	0.00585	0.001030	3.84e-03	0.00787
0.4	2.51	0.9880	0.00585	0.001030	3.84e-03	0.00787
0.5	3.16	0.9880	0.00585	0.001030	3.84e-03	0.00787
0.6	3.98	0.9880	0.00585	0.001030	3.84e-03	0.00787
0.7	5.01	0.9860	0.00586	0.001030	3.84e-03	0.00788
0.8	6.31	0.9860	0.00571	0.001010	3.73e-03	0.00770
0.9	7.94	0.9820	0.00573	0.001020	3.74e-03	0.00772
1.0	10.00	0.9820	0.00573	0.001020	3.74e-03	0.00772
1.1	12.60	0.9800	0.00574	0.001020	3.75e-03	0.00774
1.2	15.80	0.9780	0.00575	0.001020	3.75e-03	0.00775
1.3	20.00	0.9720	0.00578	0.001030	3.77e-03	0.00780
1.4	25.10	0.9700	0.00565	0.001010	3.67e-03	0.00764
1.5	31.60	0.9660	0.00567	0.001020	3.68e-03	0.00767
1.6	39.80	0.9660	0.00567	0.001020	3.68e-03	0.00767
1.7	50.10	0.9590	0.00571	0.001020	3.70e-03	0.00772
1.8	63.10	0.9500	0.00560	0.001020	3.61e-03	0.00760
1.9	79.40	0.9410	0.00566	0.001030	3.65e-03	0.00768
2.0	100.00	0.9300	0.00559	0.001030	3.57e-03	0.00760
2.1	126.00	0.9300	0.00543	0.001010	3.45e-03	0.00741
2.2	158.00	0.9170	0.00550	0.001020	3.49e-03	0.00751
2.3	200.00	0.8940	0.00528	0.001010	3.30e-03	0.00726
2.4	251.00	0.8530	0.00534	0.001040	3.30e-03	0.00738
2.5	316.00	0.8170	0.00536	0.001060	3.28e-03	0.00744
2.6	398.00	0.7530	0.00542	0.001110	3.24e-03	0.00761
2.7	501.00	0.7070	0.00514	0.001110	2.96e-03	0.00732
2.8	631.00	0.6480	0.00494	0.001150	2.68e-03	0.00721
2.9	794.00	0.5840	0.00472	0.001180	2.41e-03	0.00704
3.0	1000.00	0.4820	0.00540	0.001400	2.65e-03	0.00816
3.1	1260.00	0.4010	0.00514	0.001510	2.18e-03	0.00811
3.2	1580.00	0.3360	0.00532	0.001690	2.01e-03	0.00864
3.3	2000.00	0.2710	0.00602	0.002020	2.06e-03	0.00998
3.4	2510.00	0.2050	0.00682	0.002570	1.78e-03	0.01190
3.5	3160.00	0.1730	0.00661	0.002870	9.92e-04	0.01220
3.6	3980.00	0.1310	0.00677	0.003200	5.07e-04	0.01300
3.7	5010.00	0.1110	0.00737	0.003760	9.00e-07	0.01470
3.8	6310.00	0.0759	0.00586	0.003860	-1.71e-03	0.01340
3.9	7940.00	0.0645	0.00763	0.005640	-3.43e-03	0.01870

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.228	0.164	-0.0942	0.549
0.1	0.9880	1.26	0.240	0.173	-0.0986	0.578
0.2	0.9880	1.58	0.240	0.173	-0.0986	0.578
0.3	0.9880	2.00	0.240	0.173	-0.0986	0.578
0.4	0.9880	2.51	0.240	0.173	-0.0986	0.578
0.5	0.9880	3.16	0.240	0.173	-0.0986	0.578
0.6	0.9880	3.98	0.240	0.173	-0.0986	0.578
0.7	0.9860	5.01	0.240	0.173	-0.0989	0.579
0.8	0.9860	6.31	0.254	0.170	-0.0789	0.588
0.9	0.9820	7.94	0.254	0.170	-0.0793	0.588
1.0	0.9820	10.00	0.254	0.170	-0.0793	0.588
1.1	0.9800	12.60	0.254	0.170	-0.0797	0.588
1.2	0.9780	15.80	0.254	0.171	-0.0800	0.589
1.3	0.9720	20.00	0.254	0.171	-0.0813	0.590
1.4	0.9700	25.10	0.263	0.169	-0.0688	0.594
1.5	0.9660	31.60	0.263	0.170	-0.0696	0.595
1.6	0.9660	39.80	0.263	0.170	-0.0696	0.595
1.7	0.9590	50.10	0.263	0.170	-0.0709	0.596
1.8	0.9500	63.10	0.268	0.169	-0.0627	0.600
1.9	0.9410	79.40	0.268	0.170	-0.0651	0.602
2.0	0.9300	100.00	0.274	0.170	-0.0582	0.607
2.1	0.9300	126.00	0.291	0.166	-0.0352	0.617
2.2	0.9170	158.00	0.291	0.168	-0.0381	0.620
2.3	0.8940	200.00	0.305	0.165	-0.0182	0.629
2.4	0.8530	251.00	0.305	0.168	-0.0241	0.635
2.5	0.8170	316.00	0.305	0.170	-0.0285	0.639
2.6	0.7530	398.00	0.305	0.176	-0.0396	0.650
2.7	0.7070	501.00	0.325	0.174	-0.0165	0.666
2.8	0.6480	631.00	0.325	0.179	-0.0256	0.675
2.9	0.5840	794.00	0.325	0.182	-0.0316	0.681
3.0	0.4820	1000.00	0.325	0.207	-0.0804	0.730
3.1	0.4010	1260.00	0.325	0.219	-0.1050	0.755
3.2	0.3360	1580.00	0.325	0.240	-0.1460	0.795
3.3	0.2710	2000.00	0.325	0.280	-0.2240	0.873
3.4	0.2050	2510.00	0.325	0.348	-0.3570	1.010
3.5	0.1730	3160.00	0.325	0.385	-0.4290	1.080
3.6	0.1310	3980.00	0.325	0.426	-0.5110	1.160
3.7	0.1110	5010.00	0.325	0.498	-0.6510	1.300
3.8	0.0759	6310.00	0.325	0.511	-0.6770	1.330
3.9	0.0645	7940.00	0.325	0.739	-1.1200	1.770

IgG3 V1V2 C.1086-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00595	0.000929	0.004130	0.00777
0.1	0.9840	1.26	0.00588	0.001030	0.003860	0.00790
0.2	0.9840	1.58	0.00588	0.001030	0.003860	0.00790
0.3	0.9840	2.00	0.00588	0.001030	0.003860	0.00790
0.4	0.9840	2.51	0.00588	0.001030	0.003860	0.00790
0.5	0.9790	3.16	0.00588	0.001030	0.003850	0.00790
0.6	0.9790	3.98	0.00575	0.001020	0.003750	0.00775
0.7	0.9740	5.01	0.00568	0.001010	0.003710	0.00766
0.8	0.9690	6.31	0.00568	0.001010	0.003700	0.00767
0.9	0.9610	7.94	0.00568	0.001020	0.003680	0.00769
1.0	0.9570	10.00	0.00568	0.001030	0.003670	0.00770
1.1	0.9500	12.60	0.00565	0.001020	0.003660	0.00765
1.2	0.9390	15.80	0.00565	0.001030	0.003630	0.00767
1.3	0.9390	20.00	0.00565	0.001030	0.003630	0.00767
1.4	0.9350	25.10	0.00562	0.001020	0.003620	0.00762
1.5	0.9240	31.60	0.00562	0.001030	0.003600	0.00765
1.6	0.9100	39.80	0.00562	0.001050	0.003570	0.00768
1.7	0.9010	50.10	0.00558	0.001040	0.003540	0.00762
1.8	0.8720	63.10	0.00540	0.001010	0.003420	0.00738
1.9	0.8430	79.40	0.00540	0.001010	0.003430	0.00738
2.0	0.7660	100.00	0.00540	0.001100	0.003250	0.00755
2.1	0.7090	126.00	0.00540	0.001140	0.003170	0.00764
2.2	0.6560	158.00	0.00540	0.001100	0.003240	0.00757
2.3	0.6130	200.00	0.00540	0.001210	0.003040	0.00777
2.4	0.5500	251.00	0.00540	0.001280	0.002900	0.00790
2.5	0.4620	316.00	0.00540	0.001420	0.002630	0.00818
2.6	0.3750	398.00	0.00540	0.001730	0.002010	0.00879
2.7	0.3280	501.00	0.00540	0.001990	0.001510	0.00929
2.8	0.2490	631.00	0.00540	0.002370	0.000750	0.01010
2.9	0.1910	794.00	0.00540	0.002860	-0.000205	0.01100
3.0	0.1730	1000.00	0.00540	0.003350	-0.001160	0.01200
3.1	0.1320	1260.00	0.00540	0.003270	-0.000998	0.01180
3.2	0.0894	1580.00	0.00540	0.003430	-0.001320	0.01210
3.3	0.0645	2000.00	0.00540	0.004280	-0.003000	0.01380

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00595	0.000929	0.003920	0.00797
0.1	1.26	0.9840	0.00587	0.001030	0.003850	0.00789
0.2	1.58	0.9840	0.00587	0.001030	0.003850	0.00789
0.3	2.00	0.9840	0.00587	0.001030	0.003850	0.00789
0.4	2.51	0.9840	0.00587	0.001030	0.003850	0.00789
0.5	3.16	0.9790	0.00590	0.001030	0.003870	0.00792
0.6	3.98	0.9790	0.00575	0.001020	0.003750	0.00775
0.7	5.01	0.9740	0.00563	0.001010	0.003650	0.00760
0.8	6.31	0.9690	0.00566	0.001010	0.003670	0.00764
0.9	7.94	0.9610	0.00571	0.001020	0.003700	0.00772
1.0	10.00	0.9570	0.00574	0.001030	0.003720	0.00775
1.1	12.60	0.9500	0.00561	0.001020	0.003620	0.00761
1.2	15.80	0.9390	0.00567	0.001030	0.003650	0.00769
1.3	20.00	0.9390	0.00567	0.001030	0.003650	0.00769
1.4	25.10	0.9350	0.00555	0.001020	0.003550	0.00755
1.5	31.60	0.9240	0.00562	0.001030	0.003590	0.00764
1.6	39.80	0.9100	0.00570	0.001050	0.003640	0.00775
1.7	50.10	0.9010	0.00558	0.001040	0.003540	0.00762
1.8	63.10	0.8720	0.00521	0.001010	0.003230	0.00719
1.9	79.40	0.8430	0.00503	0.001010	0.003060	0.00701
2.0	100.00	0.7660	0.00534	0.001100	0.003190	0.00749
2.1	126.00	0.7090	0.00536	0.001140	0.003130	0.00759
2.2	158.00	0.6560	0.00474	0.001100	0.002570	0.00690
2.3	200.00	0.6130	0.00515	0.001210	0.002790	0.00752
2.4	251.00	0.5500	0.00506	0.001280	0.002560	0.00756
2.5	316.00	0.4620	0.00529	0.001420	0.002520	0.00807
2.6	398.00	0.3750	0.00595	0.001730	0.002570	0.00934
2.7	501.00	0.3280	0.00637	0.001990	0.002480	0.01030
2.8	631.00	0.2490	0.00690	0.002370	0.002250	0.01160
2.9	794.00	0.1910	0.00748	0.002860	0.001880	0.01310
3.0	1000.00	0.1730	0.00808	0.003350	0.001520	0.01460
3.1	1260.00	0.1320	0.00653	0.003270	0.000133	0.01290
3.2	1580.00	0.0894	0.00615	0.003430	-0.000571	0.01290
3.3	2000.00	0.0645	0.00649	0.004280	-0.001910	0.01490

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.228	0.164	-0.0942	0.549
0.1	0.9840	1.26	0.237	0.173	-0.1030	0.577
0.2	0.9840	1.58	0.237	0.173	-0.1030	0.577
0.3	0.9840	2.00	0.237	0.173	-0.1030	0.577
0.4	0.9840	2.51	0.237	0.173	-0.1030	0.577
0.5	0.9790	3.16	0.237	0.174	-0.1040	0.577
0.6	0.9790	3.98	0.253	0.171	-0.0812	0.588
0.7	0.9740	5.01	0.262	0.169	-0.0687	0.593
0.8	0.9690	6.31	0.262	0.169	-0.0696	0.594
0.9	0.9610	7.94	0.262	0.170	-0.0718	0.596
1.0	0.9570	10.00	0.262	0.171	-0.0727	0.597
1.1	0.9500	12.60	0.266	0.169	-0.0662	0.598
1.2	0.9390	15.80	0.266	0.171	-0.0685	0.600
1.3	0.9390	20.00	0.266	0.171	-0.0685	0.600
1.4	0.9350	25.10	0.270	0.169	-0.0617	0.602
1.5	0.9240	31.60	0.270	0.171	-0.0644	0.604
1.6	0.9100	39.80	0.270	0.172	-0.0676	0.607
1.7	0.9010	50.10	0.275	0.171	-0.0593	0.610
1.8	0.8720	63.10	0.299	0.166	-0.0264	0.624
1.9	0.8430	79.40	0.299	0.165	-0.0258	0.623
2.0	0.7660	100.00	0.299	0.175	-0.0436	0.641
2.1	0.7090	126.00	0.299	0.179	-0.0527	0.650
2.2	0.6560	158.00	0.299	0.176	-0.0455	0.643
2.3	0.6130	200.00	0.299	0.187	-0.0672	0.664
2.4	0.5500	251.00	0.299	0.194	-0.0817	0.679
2.5	0.4620	316.00	0.299	0.210	-0.1130	0.710
2.6	0.3750	398.00	0.299	0.246	-0.1840	0.781
2.7	0.3280	501.00	0.299	0.277	-0.2440	0.841
2.8	0.2490	631.00	0.299	0.324	-0.3370	0.934
2.9	0.1910	794.00	0.299	0.385	-0.4560	1.050
3.0	0.1730	1000.00	0.299	0.446	-0.5760	1.170
3.1	0.1320	1260.00	0.299	0.436	-0.5560	1.150
3.2	0.0894	1580.00	0.299	0.456	-0.5960	1.190
3.3	0.0645	2000.00	0.299	0.566	-0.8100	1.410

IgG3 V1V2 C.1086-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00595	0.000929	4.13e-03	0.00777
0.1	0.9850	1.26	0.00582	0.001010	3.84e-03	0.00781
0.2	0.9850	1.58	0.00582	0.001010	3.84e-03	0.00781
0.3	0.9850	2.00	0.00582	0.001010	3.84e-03	0.00781
0.4	0.9790	2.51	0.00582	0.001020	3.83e-03	0.00782
0.5	0.9780	3.16	0.00582	0.001020	3.83e-03	0.00782
0.6	0.9780	3.98	0.00582	0.001020	3.83e-03	0.00782
0.7	0.9720	5.01	0.00582	0.001030	3.81e-03	0.00783
0.8	0.9640	6.31	0.00582	0.001030	3.80e-03	0.00785
0.9	0.9640	7.94	0.00582	0.001030	3.80e-03	0.00785
1.0	0.9580	10.00	0.00582	0.001040	3.79e-03	0.00786
1.1	0.9490	12.60	0.00582	0.001050	3.77e-03	0.00788
1.2	0.9450	15.80	0.00582	0.001040	3.79e-03	0.00786
1.3	0.9450	20.00	0.00582	0.001020	3.82e-03	0.00783
1.4	0.9380	25.10	0.00582	0.001030	3.81e-03	0.00784
1.5	0.9190	31.60	0.00582	0.001040	3.79e-03	0.00785
1.6	0.9050	39.80	0.00582	0.001040	3.79e-03	0.00785
1.7	0.8820	50.10	0.00582	0.001070	3.73e-03	0.00792
1.8	0.8640	63.10	0.00582	0.001050	3.76e-03	0.00788
1.9	0.8640	79.40	0.00582	0.001050	3.76e-03	0.00788
2.0	0.8310	100.00	0.00582	0.001080	3.72e-03	0.00793
2.1	0.7930	126.00	0.00582	0.001070	3.73e-03	0.00792
2.2	0.7390	158.00	0.00582	0.001110	3.66e-03	0.00799
2.3	0.6760	200.00	0.00582	0.001190	3.49e-03	0.00816
2.4	0.6350	251.00	0.00582	0.001260	3.36e-03	0.00829
2.5	0.5740	316.00	0.00582	0.001390	3.10e-03	0.00855
2.6	0.5150	398.00	0.00582	0.001410	3.06e-03	0.00859
2.7	0.4440	501.00	0.00582	0.001590	2.71e-03	0.00894
2.8	0.3620	631.00	0.00582	0.001890	2.12e-03	0.00953
2.9	0.2910	794.00	0.00582	0.002230	1.45e-03	0.01020
3.0	0.2470	1000.00	0.00582	0.002570	7.95e-04	0.01090
3.1	0.1980	1260.00	0.00582	0.003020	-8.86e-05	0.01170
3.2	0.1450	1580.00	0.00582	0.003330	-7.10e-04	0.01240
3.3	0.1130	2000.00	0.00582	0.003740	-1.50e-03	0.01310
3.4	0.0892	2510.00	0.00582	0.004910	-3.81e-03	0.01550
3.5	0.0656	3160.00	0.00582	0.007050	-8.00e-03	0.01960
3.6	0.0552	3980.00	0.00582	0.005750	-5.44e-03	0.01710
3.7	0.0398	5010.00	0.00582	0.008030	-9.91e-03	0.02160

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00595	0.000929	0.003920	0.00797
0.1	1.26	0.9850	0.00572	0.001010	0.003730	0.00770
0.2	1.58	0.9850	0.00572	0.001010	0.003730	0.00770
0.3	2.00	0.9850	0.00572	0.001010	0.003730	0.00770
0.4	2.51	0.9790	0.00574	0.001020	0.003750	0.00774
0.5	3.16	0.9780	0.00575	0.001020	0.003750	0.00774
0.6	3.98	0.9780	0.00575	0.001020	0.003750	0.00774
0.7	5.01	0.9720	0.00578	0.001030	0.003770	0.00779
0.8	6.31	0.9640	0.00582	0.001030	0.003800	0.00785
0.9	7.94	0.9640	0.00582	0.001030	0.003800	0.00785
1.0	10.00	0.9580	0.00586	0.001040	0.003820	0.00790
1.1	12.60	0.9490	0.00592	0.001050	0.003860	0.00797
1.2	15.80	0.9450	0.00578	0.001040	0.003750	0.00782
1.3	20.00	0.9450	0.00563	0.001020	0.003630	0.00763
1.4	25.10	0.9380	0.00567	0.001030	0.003650	0.00768
1.5	31.60	0.9190	0.00563	0.001040	0.003600	0.00766
1.6	39.80	0.9050	0.00555	0.001040	0.003520	0.00758
1.7	50.10	0.8820	0.00572	0.001070	0.003620	0.00781
1.8	63.10	0.8640	0.00548	0.001050	0.003420	0.00754
1.9	79.40	0.8640	0.00548	0.001050	0.003420	0.00754
2.0	100.00	0.8310	0.00551	0.001080	0.003400	0.00762
2.1	126.00	0.7930	0.00524	0.001070	0.003140	0.00733
2.2	158.00	0.7390	0.00522	0.001110	0.003050	0.00738
2.3	200.00	0.6760	0.00539	0.001190	0.003050	0.00773
2.4	251.00	0.6350	0.00568	0.001260	0.003220	0.00815
2.5	316.00	0.5740	0.00622	0.001390	0.003500	0.00894
2.6	398.00	0.5150	0.00583	0.001410	0.003060	0.00860
2.7	501.00	0.4440	0.00606	0.001590	0.002950	0.00918
2.8	631.00	0.3620	0.00672	0.001890	0.003010	0.01040
2.9	794.00	0.2910	0.00730	0.002230	0.002930	0.01170
3.0	1000.00	0.2470	0.00726	0.002570	0.002240	0.01230
3.1	1260.00	0.1980	0.00858	0.003020	0.002660	0.01450
3.2	1580.00	0.1450	0.00774	0.003330	0.001210	0.01430
3.3	2000.00	0.1130	0.00855	0.003740	0.001230	0.01590
3.4	2510.00	0.0892	0.01010	0.004910	0.000497	0.01980
3.5	3160.00	0.0656	0.01290	0.007050	-0.000889	0.02680
3.6	3980.00	0.0552	0.00861	0.005750	-0.002650	0.01990
3.7	5010.00	0.0398	0.01170	0.008030	-0.004020	0.02740

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.228	0.164	-0.0942	0.549
0.1	0.9850	1.26	0.244	0.171	-0.0911	0.579
0.2	0.9850	1.58	0.244	0.171	-0.0911	0.579
0.3	0.9850	2.00	0.244	0.171	-0.0911	0.579
0.4	0.9790	2.51	0.244	0.171	-0.0919	0.579
0.5	0.9780	3.16	0.244	0.171	-0.0922	0.580
0.6	0.9780	3.98	0.244	0.171	-0.0922	0.580
0.7	0.9720	5.01	0.244	0.172	-0.0935	0.581
0.8	0.9640	6.31	0.244	0.173	-0.0952	0.583
0.9	0.9640	7.94	0.244	0.173	-0.0952	0.583
1.0	0.9580	10.00	0.244	0.174	-0.0963	0.584
1.1	0.9490	12.60	0.244	0.175	-0.0984	0.586
1.2	0.9450	15.80	0.244	0.173	-0.0960	0.584
1.3	0.9450	20.00	0.244	0.172	-0.0929	0.580
1.4	0.9380	25.10	0.244	0.172	-0.0943	0.582
1.5	0.9190	31.60	0.244	0.173	-0.0957	0.583
1.6	0.9050	39.80	0.244	0.173	-0.0956	0.583
1.7	0.8820	50.10	0.244	0.177	-0.1020	0.590
1.8	0.8640	63.10	0.244	0.175	-0.0987	0.586
1.9	0.8640	79.40	0.244	0.175	-0.0987	0.586
2.0	0.8310	100.00	0.244	0.177	-0.1030	0.591
2.1	0.7930	126.00	0.244	0.177	-0.1020	0.590
2.2	0.7390	158.00	0.244	0.180	-0.1100	0.597
2.3	0.6760	200.00	0.244	0.189	-0.1280	0.615
2.4	0.6350	251.00	0.244	0.197	-0.1420	0.629
2.5	0.5740	316.00	0.244	0.211	-0.1690	0.657
2.6	0.5150	398.00	0.244	0.213	-0.1740	0.662
2.7	0.4440	501.00	0.244	0.233	-0.2140	0.701
2.8	0.3620	631.00	0.244	0.268	-0.2820	0.770
2.9	0.2910	794.00	0.244	0.309	-0.3630	0.850
3.0	0.2470	1000.00	0.244	0.351	-0.4430	0.931
3.1	0.1980	1260.00	0.244	0.407	-0.5530	1.040
3.2	0.1450	1580.00	0.244	0.446	-0.6310	1.120
3.3	0.1130	2000.00	0.244	0.497	-0.7310	1.220
3.4	0.0892	2510.00	0.244	0.647	-1.0200	1.510
3.5	0.0656	3160.00	0.244	0.922	-1.5600	2.050
3.6	0.0552	3980.00	0.244	0.754	-1.2300	1.720
3.7	0.0398	5010.00	0.244	1.050	-1.8100	2.300

IgG_V1V2_CaseA2_elisa

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
-0.903	1.0000	0.125	0.00595	0.000929	0.004130	0.00777
-0.803	0.9790	0.157	0.00590	0.001040	0.003870	0.00793
-0.703	0.9160	0.198	0.00569	0.001050	0.003640	0.00774
-0.603	0.7770	0.249	0.00558	0.001130	0.003380	0.00779
-0.503	0.6720	0.314	0.00454	0.001070	0.002450	0.00664
-0.403	0.4790	0.395	0.00454	0.001300	0.002000	0.00708
-0.303	0.3360	0.498	0.00374	0.001450	0.000906	0.00658
-0.203	0.2160	0.626	0.00275	0.001350	0.000109	0.00539
-0.103	0.0986	0.789	0.00275	0.001880	-0.000932	0.00643

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
-0.903	0.125	1.0000	0.00595	0.000929	0.003920	0.00797
-0.803	0.157	0.9790	0.00590	0.001040	0.003870	0.00793
-0.703	0.198	0.9160	0.00569	0.001050	0.003640	0.00774
-0.603	0.249	0.7770	0.00558	0.001130	0.003380	0.00779
-0.503	0.314	0.6720	0.00450	0.001070	0.002410	0.00660
-0.403	0.395	0.4790	0.00459	0.001300	0.002050	0.00713
-0.303	0.498	0.3360	0.00374	0.001450	0.000906	0.00658
-0.203	0.626	0.2160	0.00250	0.001350	-0.000133	0.00514
-0.103	0.789	0.0986	0.00299	0.001880	-0.000690	0.00667

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
-0.903	1.0000	0.125	0.228	0.164	-0.0942	0.549
-0.803	0.9790	0.157	0.234	0.174	-0.1080	0.575
-0.703	0.9160	0.198	0.261	0.173	-0.0773	0.600
-0.603	0.7770	0.249	0.275	0.180	-0.0772	0.627
-0.503	0.6720	0.314	0.410	0.163	0.0910	0.729
-0.403	0.4790	0.395	0.410	0.189	0.0406	0.780
-0.303	0.3360	0.498	0.514	0.201	0.1210	0.907
-0.203	0.2160	0.626	0.643	0.182	0.2860	1.000
-0.103	0.0986	0.789	0.643	0.249	0.1550	1.130

IgG_gp70.V1V2CaseA2

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00595	0.000929	0.004130	0.00777
0.1	0.9950	1.26	0.00585	0.001020	0.003850	0.00785
0.2	0.9950	1.58	0.00585	0.001020	0.003850	0.00785
0.3	0.9950	2.00	0.00585	0.001020	0.003850	0.00785
0.4	0.9930	2.51	0.00585	0.001020	0.003850	0.00786
0.5	0.9930	3.16	0.00585	0.001020	0.003850	0.00786
0.6	0.9840	3.98	0.00585	0.001030	0.003830	0.00787
0.7	0.9840	5.01	0.00585	0.001030	0.003830	0.00787
0.8	0.9840	6.31	0.00585	0.001030	0.003830	0.00787
0.9	0.9840	7.94	0.00585	0.001030	0.003830	0.00787
1.0	0.9770	10.00	0.00585	0.001040	0.003820	0.00788
1.1	0.9700	12.60	0.00580	0.001030	0.003780	0.00782
1.2	0.9640	15.80	0.00569	0.001020	0.003690	0.00769
1.3	0.9580	20.00	0.00557	0.001010	0.003590	0.00755
1.4	0.9450	25.10	0.00550	0.001010	0.003520	0.00747
1.5	0.9290	31.60	0.00549	0.001010	0.003500	0.00748
1.6	0.9200	39.80	0.00549	0.001020	0.003490	0.00749
1.7	0.9110	50.10	0.00549	0.001030	0.003460	0.00752
1.8	0.8930	63.10	0.00519	0.001010	0.003220	0.00716
1.9	0.8530	79.40	0.00513	0.001010	0.003140	0.00712
2.0	0.8040	100.00	0.00513	0.001060	0.003050	0.00720
2.1	0.7400	126.00	0.00481	0.001040	0.002770	0.00685
2.2	0.6750	158.00	0.00481	0.001110	0.002650	0.00698
2.3	0.6450	200.00	0.00481	0.001130	0.002590	0.00704
2.4	0.5840	251.00	0.00460	0.001130	0.002390	0.00681
2.5	0.5120	316.00	0.00460	0.001280	0.002090	0.00711
2.6	0.4520	398.00	0.00438	0.001280	0.001870	0.00689
2.7	0.3730	501.00	0.00396	0.001300	0.001400	0.00651
2.8	0.2950	631.00	0.00309	0.001270	0.000607	0.00557
2.9	0.2310	794.00	0.00293	0.001130	0.000711	0.00515
3.0	0.1630	1000.00	0.00293	0.001970	-0.000929	0.00679
3.1	0.1400	1260.00	0.00293	0.001580	-0.000160	0.00602
3.2	0.0888	1580.00	0.00293	0.002250	-0.001470	0.00733

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00595	0.000929	3.92e-03	0.00797
0.1	1.26	0.9950	0.00582	0.001020	3.82e-03	0.00782
0.2	1.58	0.9950	0.00582	0.001020	3.82e-03	0.00782
0.3	2.00	0.9950	0.00582	0.001020	3.82e-03	0.00782
0.4	2.51	0.9930	0.00583	0.001020	3.82e-03	0.00783
0.5	3.16	0.9930	0.00583	0.001020	3.82e-03	0.00783
0.6	3.98	0.9840	0.00587	0.001030	3.85e-03	0.00789
0.7	5.01	0.9840	0.00587	0.001030	3.85e-03	0.00789
0.8	6.31	0.9840	0.00587	0.001030	3.85e-03	0.00789
0.9	7.94	0.9840	0.00587	0.001030	3.85e-03	0.00789
1.0	10.00	0.9770	0.00591	0.001040	3.88e-03	0.00794
1.1	12.60	0.9700	0.00580	0.001030	3.78e-03	0.00782
1.2	15.80	0.9640	0.00569	0.001020	3.69e-03	0.00769
1.3	20.00	0.9580	0.00557	0.001010	3.59e-03	0.00755
1.4	25.10	0.9450	0.00550	0.001010	3.52e-03	0.00747
1.5	31.60	0.9290	0.00544	0.001010	3.46e-03	0.00743
1.6	39.80	0.9200	0.00548	0.001020	3.48e-03	0.00748
1.7	50.10	0.9110	0.00554	0.001030	3.52e-03	0.00757
1.8	63.10	0.8930	0.00519	0.001010	3.22e-03	0.00716
1.9	79.40	0.8530	0.00507	0.001010	3.08e-03	0.00706
2.0	100.00	0.8040	0.00519	0.001060	3.11e-03	0.00726
2.1	126.00	0.7400	0.00475	0.001040	2.71e-03	0.00679
2.2	158.00	0.6750	0.00484	0.001110	2.67e-03	0.00701
2.3	200.00	0.6450	0.00485	0.001130	2.63e-03	0.00707
2.4	251.00	0.5840	0.00440	0.001130	2.19e-03	0.00661
2.5	316.00	0.5120	0.00481	0.001280	2.30e-03	0.00732
2.6	398.00	0.4520	0.00438	0.001280	1.87e-03	0.00689
2.7	501.00	0.3730	0.00396	0.001300	1.40e-03	0.00651
2.8	631.00	0.2950	0.00309	0.001270	6.07e-04	0.00557
2.9	794.00	0.2310	0.00213	0.001130	-8.53e-05	0.00435
3.0	1000.00	0.1630	0.00343	0.001970	-4.32e-04	0.00729
3.1	1260.00	0.1400	0.00258	0.001580	-5.10e-04	0.00567
3.2	1580.00	0.0888	0.00358	0.002250	-8.24e-04	0.00798

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.228	0.164	-0.09420	0.549
0.1	0.9950	1.26	0.240	0.172	-0.09700	0.577
0.2	0.9950	1.58	0.240	0.172	-0.09700	0.577
0.3	0.9950	2.00	0.240	0.172	-0.09700	0.577
0.4	0.9930	2.51	0.240	0.172	-0.09730	0.578
0.5	0.9930	3.16	0.240	0.172	-0.09730	0.578
0.6	0.9840	3.98	0.240	0.173	-0.09890	0.579
0.7	0.9840	5.01	0.240	0.173	-0.09890	0.579
0.8	0.9840	6.31	0.240	0.173	-0.09890	0.579
0.9	0.9840	7.94	0.240	0.173	-0.09890	0.579
1.0	0.9770	10.00	0.240	0.174	-0.10000	0.581
1.1	0.9700	12.60	0.247	0.172	-0.09060	0.584
1.2	0.9640	15.80	0.261	0.170	-0.07150	0.594
1.3	0.9580	20.00	0.277	0.167	-0.05110	0.605
1.4	0.9450	25.10	0.286	0.167	-0.04030	0.613
1.5	0.9290	31.60	0.287	0.167	-0.04000	0.615
1.6	0.9200	39.80	0.287	0.168	-0.04150	0.616
1.7	0.9110	50.10	0.287	0.169	-0.04410	0.619
1.8	0.8930	63.10	0.326	0.163	0.00665	0.645
1.9	0.8530	79.40	0.334	0.163	0.01470	0.654
2.0	0.8040	100.00	0.334	0.168	0.00537	0.663
2.1	0.7400	126.00	0.375	0.162	0.05650	0.693
2.2	0.6750	158.00	0.375	0.170	0.04250	0.707
2.3	0.6450	200.00	0.375	0.173	0.03660	0.713
2.4	0.5840	251.00	0.403	0.170	0.06940	0.736
2.5	0.5120	316.00	0.403	0.187	0.03560	0.770
2.6	0.4520	398.00	0.431	0.185	0.06810	0.795
2.7	0.3730	501.00	0.486	0.185	0.12400	0.848
2.8	0.2950	631.00	0.599	0.174	0.25800	0.941
2.9	0.2310	794.00	0.620	0.157	0.31200	0.927
3.0	0.1630	1000.00	0.620	0.261	0.10700	1.130
3.1	0.1400	1260.00	0.620	0.212	0.20400	1.030
3.2	0.0888	1580.00	0.620	0.297	0.03790	1.200

IgG_A244D11K169

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00595	0.000929	0.00413	0.00777
0.1	0.9940	1.26	0.00585	0.001020	0.00384	0.00785
0.2	0.9940	1.58	0.00585	0.001020	0.00384	0.00785
0.3	0.9940	2.00	0.00585	0.001020	0.00384	0.00785
0.4	0.9940	2.51	0.00585	0.001020	0.00384	0.00785
0.5	0.9940	3.16	0.00585	0.001020	0.00384	0.00785
0.6	0.9940	3.98	0.00585	0.001020	0.00384	0.00785
0.7	0.9920	5.01	0.00585	0.001020	0.00384	0.00785
0.8	0.9920	6.31	0.00585	0.001020	0.00384	0.00785
0.9	0.9920	7.94	0.00585	0.001020	0.00384	0.00785
1.0	0.9920	10.00	0.00585	0.001020	0.00384	0.00785
1.1	0.9920	12.60	0.00585	0.001020	0.00384	0.00785
1.2	0.9920	15.80	0.00585	0.001020	0.00384	0.00785
1.3	0.9920	20.00	0.00585	0.001020	0.00384	0.00785
1.4	0.9900	25.10	0.00585	0.001030	0.00383	0.00786
1.5	0.9900	31.60	0.00585	0.001030	0.00383	0.00786
1.6	0.9890	39.80	0.00585	0.001030	0.00383	0.00786
1.7	0.9890	50.10	0.00585	0.001030	0.00383	0.00786
1.8	0.9880	63.10	0.00585	0.001010	0.00386	0.00783
1.9	0.9880	79.40	0.00585	0.001010	0.00386	0.00783
2.0	0.9870	100.00	0.00585	0.001020	0.00386	0.00784
2.1	0.9870	126.00	0.00585	0.001020	0.00386	0.00784
2.2	0.9850	158.00	0.00585	0.001020	0.00385	0.00784
2.3	0.9850	200.00	0.00585	0.001020	0.00385	0.00784
2.4	0.9850	251.00	0.00585	0.001020	0.00385	0.00784
2.5	0.9850	316.00	0.00585	0.001020	0.00385	0.00784
2.6	0.9850	398.00	0.00585	0.001020	0.00385	0.00784
2.7	0.9850	501.00	0.00585	0.001000	0.00388	0.00781
2.8	0.9690	631.00	0.00585	0.001020	0.00385	0.00784
2.9	0.9610	794.00	0.00585	0.001010	0.00387	0.00782
3.0	0.9520	1000.00	0.00585	0.001000	0.00388	0.00781
3.1	0.9150	1260.00	0.00585	0.001030	0.00383	0.00786
3.2	0.8590	1580.00	0.00585	0.001080	0.00374	0.00796
3.3	0.8030	2000.00	0.00585	0.001100	0.00369	0.00800
3.4	0.7020	2510.00	0.00585	0.001160	0.00357	0.00813
3.5	0.5770	3160.00	0.00585	0.001350	0.00321	0.00849
3.6	0.4180	3980.00	0.00585	0.001700	0.00252	0.00917
3.7	0.3710	5010.00	0.00585	0.001770	0.00237	0.00932
3.8	0.2660	6310.00	0.00585	0.002060	0.00180	0.00989
3.9	0.1340	7940.00	0.00585	0.004570	-0.00312	0.01480
4.0	0.0839	10000.00	0.00585	0.005760	-0.00545	0.01710
4.1	0.0476	12600.00	0.00585	0.010400	-0.01460	0.02630
4.2	0.0252	15800.00	0.00585	0.019300	-0.03190	0.04360

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00595	0.000929	0.00392	0.00797
0.1	1.26	0.9940	0.00583	0.001020	0.00382	0.00783
0.2	1.58	0.9940	0.00583	0.001020	0.00382	0.00783
0.3	2.00	0.9940	0.00583	0.001020	0.00382	0.00783
0.4	2.51	0.9940	0.00583	0.001020	0.00382	0.00783
0.5	3.16	0.9940	0.00583	0.001020	0.00382	0.00783
0.6	3.98	0.9940	0.00583	0.001020	0.00382	0.00783
0.7	5.01	0.9920	0.00583	0.001020	0.00383	0.00784
0.8	6.31	0.9920	0.00583	0.001020	0.00383	0.00784
0.9	7.94	0.9920	0.00583	0.001020	0.00383	0.00784
1.0	10.00	0.9920	0.00583	0.001020	0.00383	0.00784
1.1	12.60	0.9920	0.00583	0.001020	0.00383	0.00784
1.2	15.80	0.9920	0.00583	0.001020	0.00383	0.00784
1.3	20.00	0.9920	0.00583	0.001020	0.00383	0.00784
1.4	25.10	0.9900	0.00584	0.001030	0.00383	0.00785
1.5	31.60	0.9900	0.00584	0.001030	0.00383	0.00785
1.6	39.80	0.9890	0.00585	0.001030	0.00384	0.00787
1.7	50.10	0.9890	0.00585	0.001030	0.00384	0.00787
1.8	63.10	0.9880	0.00570	0.001010	0.00372	0.00769
1.9	79.40	0.9880	0.00570	0.001010	0.00372	0.00769
2.0	100.00	0.9870	0.00572	0.001020	0.00373	0.00771
2.1	126.00	0.9870	0.00572	0.001020	0.00373	0.00771
2.2	158.00	0.9850	0.00573	0.001020	0.00373	0.00772
2.3	200.00	0.9850	0.00573	0.001020	0.00373	0.00772
2.4	251.00	0.9850	0.00573	0.001020	0.00373	0.00772
2.5	316.00	0.9850	0.00573	0.001020	0.00373	0.00772
2.6	398.00	0.9850	0.00573	0.001020	0.00373	0.00772
2.7	501.00	0.9850	0.00559	0.001000	0.00362	0.00755
2.8	631.00	0.9690	0.00568	0.001020	0.00368	0.00767
2.9	794.00	0.9610	0.00556	0.001010	0.00358	0.00753
3.0	1000.00	0.9520	0.00545	0.001000	0.00349	0.00742
3.1	1260.00	0.9150	0.00552	0.001030	0.00350	0.00754
3.2	1580.00	0.8590	0.00568	0.001080	0.00357	0.00779
3.3	2000.00	0.8030	0.00554	0.001100	0.00339	0.00770
3.4	2510.00	0.7020	0.00545	0.001160	0.00317	0.00773
3.5	3160.00	0.5770	0.00568	0.001350	0.00304	0.00832
3.6	3980.00	0.4180	0.00655	0.001700	0.00322	0.00988
3.7	5010.00	0.3710	0.00645	0.001770	0.00298	0.00992
3.8	6310.00	0.2660	0.00627	0.002060	0.00223	0.01030
3.9	7940.00	0.1340	0.01230	0.004570	0.00331	0.02120
4.0	10000.00	0.0839	0.00970	0.005760	-0.00160	0.02100
4.1	12600.00	0.0476	0.01520	0.010400	-0.00526	0.03560
4.2	15800.00	0.0252	0.02460	0.019300	-0.01320	0.06230

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.228	0.164	-0.0942	0.549
0.1	0.9940	1.26	0.241	0.172	-0.0965	0.578
0.2	0.9940	1.58	0.241	0.172	-0.0965	0.578
0.3	0.9940	2.00	0.241	0.172	-0.0965	0.578
0.4	0.9940	2.51	0.241	0.172	-0.0965	0.578
0.5	0.9940	3.16	0.241	0.172	-0.0965	0.578
0.6	0.9940	3.98	0.241	0.172	-0.0965	0.578
0.7	0.9920	5.01	0.241	0.172	-0.0968	0.579
0.8	0.9920	6.31	0.241	0.172	-0.0968	0.579
0.9	0.9920	7.94	0.241	0.172	-0.0968	0.579
1.0	0.9920	10.00	0.241	0.172	-0.0968	0.579
1.1	0.9920	12.60	0.241	0.172	-0.0968	0.579
1.2	0.9920	15.80	0.241	0.172	-0.0968	0.579
1.3	0.9920	20.00	0.241	0.172	-0.0968	0.579
1.4	0.9900	25.10	0.241	0.172	-0.0972	0.579
1.5	0.9900	31.60	0.241	0.172	-0.0972	0.579
1.6	0.9890	39.80	0.241	0.173	-0.0975	0.579
1.7	0.9890	50.10	0.241	0.173	-0.0975	0.579
1.8	0.9880	63.10	0.241	0.171	-0.0946	0.576
1.9	0.9880	79.40	0.241	0.171	-0.0946	0.576
2.0	0.9870	100.00	0.241	0.171	-0.0950	0.577
2.1	0.9870	126.00	0.241	0.171	-0.0950	0.577
2.2	0.9850	158.00	0.241	0.172	-0.0954	0.577
2.3	0.9850	200.00	0.241	0.172	-0.0954	0.577
2.4	0.9850	251.00	0.241	0.172	-0.0954	0.577
2.5	0.9850	316.00	0.241	0.172	-0.0954	0.577
2.6	0.9850	398.00	0.241	0.172	-0.0954	0.577
2.7	0.9850	501.00	0.241	0.170	-0.0925	0.574
2.8	0.9690	631.00	0.241	0.172	-0.0955	0.577
2.9	0.9610	794.00	0.241	0.171	-0.0935	0.575
3.0	0.9520	1000.00	0.241	0.170	-0.0922	0.574
3.1	0.9150	1260.00	0.241	0.173	-0.0977	0.579
3.2	0.8590	1580.00	0.241	0.178	-0.1070	0.589
3.3	0.8030	2000.00	0.241	0.180	-0.1120	0.593
3.4	0.7020	2510.00	0.241	0.187	-0.1250	0.606
3.5	0.5770	3160.00	0.241	0.206	-0.1640	0.645
3.6	0.4180	3980.00	0.241	0.246	-0.2420	0.723
3.7	0.3710	5010.00	0.241	0.255	-0.2590	0.740
3.8	0.2660	6310.00	0.241	0.289	-0.3260	0.808
3.9	0.1340	7940.00	0.241	0.604	-0.9430	1.420
4.0	0.0839	10000.00	0.241	0.756	-1.2400	1.720
4.1	0.0476	12600.00	0.241	1.360	-2.4200	2.910
4.2	0.0252	15800.00	0.241	2.500	-4.6700	5.150

IgG_gp70ClAEV1V2

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00597	0.000929	0.00415	0.00779
0.1	0.997	1.26	0.00597	0.001030	0.00394	0.00800
0.2	0.997	1.58	0.00597	0.001030	0.00394	0.00800
0.3	0.997	2.00	0.00597	0.001030	0.00394	0.00800
0.4	0.995	2.51	0.00597	0.001040	0.00394	0.00800
0.5	0.994	3.16	0.00597	0.001040	0.00394	0.00800
0.6	0.992	3.98	0.00597	0.001040	0.00393	0.00801
0.7	0.992	5.01	0.00597	0.001040	0.00393	0.00801
0.8	0.992	6.31	0.00597	0.001040	0.00393	0.00801
0.9	0.992	7.94	0.00597	0.001040	0.00393	0.00801
1.0	0.992	10.00	0.00597	0.001040	0.00393	0.00801
1.1	0.992	12.60	0.00597	0.001040	0.00393	0.00801
1.2	0.992	15.80	0.00597	0.001040	0.00393	0.00801
1.3	0.992	20.00	0.00584	0.001020	0.00383	0.00785
1.4	0.992	25.10	0.00584	0.001020	0.00383	0.00785
1.5	0.992	31.60	0.00584	0.001020	0.00383	0.00785
1.6	0.992	39.80	0.00584	0.001020	0.00383	0.00785
1.7	0.990	50.10	0.00584	0.001030	0.00383	0.00785
1.8	0.990	63.10	0.00584	0.001030	0.00383	0.00785
1.9	0.990	79.40	0.00584	0.001030	0.00383	0.00785
2.0	0.990	100.00	0.00584	0.001030	0.00383	0.00785
2.1	0.990	126.00	0.00584	0.001030	0.00383	0.00785
2.2	0.990	158.00	0.00584	0.001030	0.00383	0.00785
2.3	0.990	200.00	0.00584	0.001030	0.00383	0.00785
2.4	0.989	251.00	0.00584	0.001030	0.00383	0.00786
2.5	0.987	316.00	0.00584	0.001030	0.00382	0.00786
2.6	0.987	398.00	0.00573	0.001020	0.00374	0.00772
2.7	0.987	501.00	0.00573	0.001020	0.00374	0.00772
2.8	0.987	631.00	0.00573	0.001020	0.00374	0.00772
2.9	0.981	794.00	0.00573	0.001020	0.00373	0.00773
3.0	0.981	1000.00	0.00573	0.001020	0.00373	0.00773
3.1	0.981	1260.00	0.00562	0.001010	0.00365	0.00759
3.2	0.976	1580.00	0.00562	0.001010	0.00364	0.00760
3.3	0.976	2000.00	0.00549	0.000996	0.00354	0.00744
3.4	0.967	2510.00	0.00540	0.000990	0.00346	0.00735
3.5	0.967	3160.00	0.00540	0.000990	0.00346	0.00735
3.6	0.963	3980.00	0.00540	0.000994	0.00346	0.00735
3.7	0.963	5010.00	0.00515	0.000963	0.00326	0.00704
3.8	0.951	6310.00	0.00515	0.000973	0.00324	0.00706
3.9	0.927	7940.00	0.00512	0.000969	0.00322	0.00702
4.0	0.922	10000.00	0.00512	0.000956	0.00325	0.00699
4.1	0.872	12600.00	0.00512	0.000998	0.00317	0.00708
4.2	0.807	15800.00	0.00512	0.001070	0.00303	0.00721
4.3	0.722	20000.00	0.00512	0.001150	0.00287	0.00738
4.4	0.408	25100.00	0.00512	0.001570	0.00204	0.00820

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00595	0.000929	0.00392	0.00797
0.1	1.26	0.997	0.00596	0.001030	0.00393	0.00799
0.2	1.58	0.997	0.00596	0.001030	0.00393	0.00799
0.3	2.00	0.997	0.00596	0.001030	0.00393	0.00799
0.4	2.51	0.995	0.00596	0.001040	0.00393	0.00800
0.5	3.16	0.994	0.00597	0.001040	0.00394	0.00801
0.6	3.98	0.992	0.00598	0.001040	0.00394	0.00802
0.7	5.01	0.992	0.00598	0.001040	0.00394	0.00802
0.8	6.31	0.992	0.00598	0.001040	0.00394	0.00802
0.9	7.94	0.992	0.00598	0.001040	0.00394	0.00802
1.0	10.00	0.992	0.00598	0.001040	0.00394	0.00802
1.1	12.60	0.992	0.00598	0.001040	0.00394	0.00802
1.2	15.80	0.992	0.00598	0.001040	0.00394	0.00802
1.3	20.00	0.992	0.00583	0.001020	0.00383	0.00784
1.4	25.10	0.992	0.00583	0.001020	0.00383	0.00784
1.5	31.60	0.992	0.00583	0.001020	0.00383	0.00784
1.6	39.80	0.992	0.00583	0.001020	0.00383	0.00784
1.7	50.10	0.990	0.00584	0.001030	0.00383	0.00785
1.8	63.10	0.990	0.00584	0.001030	0.00383	0.00785
1.9	79.40	0.990	0.00584	0.001030	0.00383	0.00785
2.0	100.00	0.990	0.00584	0.001030	0.00383	0.00785
2.1	126.00	0.990	0.00584	0.001030	0.00383	0.00785
2.2	158.00	0.990	0.00584	0.001030	0.00383	0.00785
2.3	200.00	0.990	0.00584	0.001030	0.00383	0.00785
2.4	251.00	0.989	0.00586	0.001030	0.00384	0.00787
2.5	316.00	0.987	0.00586	0.001030	0.00385	0.00788
2.6	398.00	0.987	0.00572	0.001020	0.00373	0.00771
2.7	501.00	0.987	0.00572	0.001020	0.00373	0.00771
2.8	631.00	0.987	0.00572	0.001020	0.00373	0.00771
2.9	794.00	0.981	0.00575	0.001020	0.00374	0.00775
3.0	1000.00	0.981	0.00575	0.001020	0.00374	0.00775
3.1	1260.00	0.981	0.00560	0.001010	0.00363	0.00758
3.2	1580.00	0.976	0.00564	0.001010	0.00366	0.00762
3.3	2000.00	0.976	0.00549	0.000996	0.00354	0.00744
3.4	2510.00	0.967	0.00540	0.000990	0.00346	0.00734
3.5	3160.00	0.967	0.00540	0.000990	0.00346	0.00734
3.6	3980.00	0.963	0.00542	0.000994	0.00347	0.00737
3.7	5010.00	0.963	0.00512	0.000963	0.00324	0.00701
3.8	6310.00	0.951	0.00518	0.000973	0.00327	0.00708
3.9	7940.00	0.927	0.00501	0.000969	0.00311	0.00691
4.0	10000.00	0.922	0.00487	0.000956	0.00300	0.00674
4.1	12600.00	0.872	0.00499	0.000998	0.00303	0.00694
4.2	15800.00	0.807	0.00522	0.001070	0.00313	0.00730
4.3	20000.00	0.722	0.00541	0.001150	0.00316	0.00767
4.4	25100.00	0.408	0.00534	0.001570	0.00226	0.00842

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.225	0.164	-0.09750	0.547
0.1	0.997	1.26	0.225	0.175	-0.11800	0.567
0.2	0.997	1.58	0.225	0.175	-0.11800	0.567
0.3	0.997	2.00	0.225	0.175	-0.11800	0.567
0.4	0.995	2.51	0.225	0.175	-0.11800	0.568
0.5	0.994	3.16	0.225	0.175	-0.11800	0.568
0.6	0.992	3.98	0.225	0.175	-0.11900	0.568
0.7	0.992	5.01	0.225	0.175	-0.11900	0.568
0.8	0.992	6.31	0.225	0.175	-0.11900	0.568
0.9	0.992	7.94	0.225	0.175	-0.11900	0.568
1.0	0.992	10.00	0.225	0.175	-0.11900	0.568
1.1	0.992	12.60	0.225	0.175	-0.11900	0.568
1.2	0.992	15.80	0.225	0.175	-0.11900	0.568
1.3	0.992	20.00	0.241	0.172	-0.09620	0.579
1.4	0.992	25.10	0.241	0.172	-0.09620	0.579
1.5	0.992	31.60	0.241	0.172	-0.09620	0.579
1.6	0.992	39.80	0.241	0.172	-0.09620	0.579
1.7	0.990	50.10	0.241	0.172	-0.09660	0.579
1.8	0.990	63.10	0.241	0.172	-0.09660	0.579
1.9	0.990	79.40	0.241	0.172	-0.09660	0.579
2.0	0.990	100.00	0.241	0.172	-0.09660	0.579
2.1	0.990	126.00	0.241	0.172	-0.09660	0.579
2.2	0.990	158.00	0.241	0.172	-0.09660	0.579
2.3	0.990	200.00	0.241	0.172	-0.09660	0.579
2.4	0.989	251.00	0.241	0.173	-0.09710	0.580
2.5	0.987	316.00	0.241	0.173	-0.09740	0.580
2.6	0.987	398.00	0.256	0.170	-0.07710	0.589
2.7	0.987	501.00	0.256	0.170	-0.07710	0.589
2.8	0.987	631.00	0.256	0.170	-0.07710	0.589
2.9	0.981	794.00	0.256	0.171	-0.07820	0.590
3.0	0.981	1000.00	0.256	0.171	-0.07820	0.590
3.1	0.981	1260.00	0.270	0.168	-0.05870	0.599
3.2	0.976	1580.00	0.270	0.168	-0.05960	0.600
3.3	0.976	2000.00	0.287	0.165	-0.03710	0.611
3.4	0.967	2510.00	0.298	0.164	-0.02250	0.619
3.5	0.967	3160.00	0.298	0.164	-0.02250	0.619
3.6	0.963	3980.00	0.298	0.164	-0.02330	0.620
3.7	0.963	5010.00	0.331	0.158	0.02180	0.641
3.8	0.951	6310.00	0.331	0.159	0.01970	0.643
3.9	0.927	7940.00	0.335	0.158	0.02490	0.645
4.0	0.922	10000.00	0.335	0.157	0.02770	0.642
4.1	0.872	12600.00	0.335	0.161	0.01920	0.651
4.2	0.807	15800.00	0.335	0.168	0.00509	0.665
4.3	0.722	20000.00	0.335	0.177	-0.01280	0.683
4.4	0.408	25100.00	0.335	0.225	-0.10700	0.777

IgG_gp70V1V2A

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00595	0.000929	0.004130	0.00777
0.1	0.9920	1.26	0.00590	0.001020	0.003890	0.00791
0.2	0.9920	1.58	0.00590	0.001020	0.003890	0.00791
0.3	0.9920	2.00	0.00590	0.001020	0.003890	0.00791
0.4	0.9900	2.51	0.00590	0.001030	0.003890	0.00791
0.5	0.9880	3.16	0.00590	0.001030	0.003890	0.00792
0.6	0.9880	3.98	0.00590	0.001030	0.003890	0.00792
0.7	0.9870	5.01	0.00590	0.001030	0.003880	0.00792
0.8	0.9850	6.31	0.00590	0.001030	0.003880	0.00792
0.9	0.9810	7.94	0.00590	0.001030	0.003880	0.00793
1.0	0.9810	10.00	0.00590	0.001030	0.003880	0.00793
1.1	0.9810	12.60	0.00590	0.001030	0.003880	0.00793
1.2	0.9660	15.80	0.00590	0.001050	0.003840	0.00796
1.3	0.9660	20.00	0.00590	0.001050	0.003840	0.00796
1.4	0.9660	25.10	0.00590	0.001050	0.003840	0.00796
1.5	0.9660	31.60	0.00590	0.001050	0.003840	0.00796
1.6	0.9500	39.80	0.00590	0.001050	0.003840	0.00796
1.7	0.9440	50.10	0.00590	0.001060	0.003820	0.00798
1.8	0.9390	63.10	0.00568	0.001030	0.003660	0.00771
1.9	0.9290	79.40	0.00560	0.001030	0.003580	0.00762
2.0	0.8990	100.00	0.00559	0.001040	0.003540	0.00763
2.1	0.8850	126.00	0.00521	0.001010	0.003230	0.00719
2.2	0.8550	158.00	0.00491	0.000996	0.002950	0.00686
2.3	0.8420	200.00	0.00462	0.000968	0.002720	0.00651
2.4	0.8180	251.00	0.00423	0.000935	0.002400	0.00606
2.5	0.7640	316.00	0.00395	0.000928	0.002130	0.00576
2.6	0.7150	398.00	0.00384	0.000948	0.001980	0.00570
2.7	0.6380	501.00	0.00377	0.000965	0.001880	0.00566
2.8	0.5210	631.00	0.00377	0.001100	0.001620	0.00592
2.9	0.4700	794.00	0.00377	0.001200	0.001430	0.00612
3.0	0.4320	1000.00	0.00377	0.001220	0.001380	0.00617
3.1	0.3450	1260.00	0.00377	0.001330	0.001170	0.00637
3.2	0.2870	1580.00	0.00377	0.001490	0.000858	0.00669
3.3	0.2200	2000.00	0.00377	0.001740	0.000354	0.00719
3.4	0.1630	2510.00	0.00377	0.002690	-0.001510	0.00905
3.5	0.1270	3160.00	0.00377	0.004290	-0.004640	0.01220
3.6	0.0993	3980.00	0.00377	0.004950	-0.005920	0.01350
3.7	0.0799	5010.00	0.00377	0.004820	-0.005670	0.01320

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00595	0.000929	0.003920	0.00797
0.1	1.26	0.9920	0.00584	0.001020	0.003830	0.00784
0.2	1.58	0.9920	0.00584	0.001020	0.003830	0.00784
0.3	2.00	0.9920	0.00584	0.001020	0.003830	0.00784
0.4	2.51	0.9900	0.00585	0.001030	0.003840	0.00786
0.5	3.16	0.9880	0.00586	0.001030	0.003840	0.00787
0.6	3.98	0.9880	0.00586	0.001030	0.003840	0.00787
0.7	5.01	0.9870	0.00586	0.001030	0.003850	0.00788
0.8	6.31	0.9850	0.00587	0.001030	0.003850	0.00790
0.9	7.94	0.9810	0.00590	0.001030	0.003870	0.00792
1.0	10.00	0.9810	0.00590	0.001030	0.003870	0.00792
1.1	12.60	0.9810	0.00590	0.001030	0.003870	0.00792
1.2	15.80	0.9660	0.00599	0.001050	0.003930	0.00805
1.3	20.00	0.9660	0.00599	0.001050	0.003930	0.00805
1.4	25.10	0.9660	0.00599	0.001050	0.003930	0.00805
1.5	31.60	0.9660	0.00599	0.001050	0.003930	0.00805
1.6	39.80	0.9500	0.00592	0.001050	0.003860	0.00798
1.7	50.10	0.9440	0.00597	0.001060	0.003890	0.00804
1.8	63.10	0.9390	0.00568	0.001030	0.003660	0.00771
1.9	79.40	0.9290	0.00560	0.001030	0.003580	0.00762
2.0	100.00	0.8990	0.00559	0.001040	0.003540	0.00763
2.1	126.00	0.8850	0.00521	0.001010	0.003230	0.00719
2.2	158.00	0.8550	0.00491	0.000996	0.002950	0.00686
2.3	200.00	0.8420	0.00462	0.000968	0.002720	0.00651
2.4	251.00	0.8180	0.00423	0.000935	0.002400	0.00606
2.5	316.00	0.7640	0.00395	0.000928	0.002130	0.00576
2.6	398.00	0.7150	0.00384	0.000948	0.001980	0.00570
2.7	501.00	0.6380	0.00359	0.000965	0.001690	0.00548
2.8	631.00	0.5210	0.00375	0.001100	0.001600	0.00590
2.9	794.00	0.4700	0.00394	0.001200	0.001590	0.00628
3.0	1000.00	0.4320	0.00383	0.001220	0.001440	0.00623
3.1	1260.00	0.3450	0.00360	0.001330	0.000997	0.00620
3.2	1580.00	0.2870	0.00381	0.001490	0.000896	0.00673
3.3	2000.00	0.2200	0.00394	0.001740	0.000523	0.00736
3.4	2510.00	0.1630	0.00597	0.002690	0.000691	0.01130
3.5	3160.00	0.1270	0.00909	0.004290	0.000679	0.01750
3.6	3980.00	0.0993	0.00928	0.004950	-0.000413	0.01900
3.7	5010.00	0.0799	0.00699	0.004820	-0.002460	0.01640

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.228	0.164	-0.09420	0.549
0.1	0.9920	1.26	0.234	0.173	-0.10500	0.573
0.2	0.9920	1.58	0.234	0.173	-0.10500	0.573
0.3	0.9920	2.00	0.234	0.173	-0.10500	0.573
0.4	0.9900	2.51	0.234	0.173	-0.10600	0.573
0.5	0.9880	3.16	0.234	0.173	-0.10600	0.573
0.6	0.9880	3.98	0.234	0.173	-0.10600	0.573
0.7	0.9870	5.01	0.234	0.173	-0.10600	0.574
0.8	0.9850	6.31	0.234	0.174	-0.10700	0.574
0.9	0.9810	7.94	0.234	0.174	-0.10700	0.574
1.0	0.9810	10.00	0.234	0.174	-0.10700	0.574
1.1	0.9810	12.60	0.234	0.174	-0.10700	0.574
1.2	0.9660	15.80	0.234	0.176	-0.11000	0.578
1.3	0.9660	20.00	0.234	0.176	-0.11000	0.578
1.4	0.9660	25.10	0.234	0.176	-0.11000	0.578
1.5	0.9660	31.60	0.234	0.176	-0.11000	0.578
1.6	0.9500	39.80	0.234	0.176	-0.11100	0.578
1.7	0.9440	50.10	0.234	0.177	-0.11200	0.580
1.8	0.9390	63.10	0.262	0.171	-0.07360	0.597
1.9	0.9290	79.40	0.273	0.170	-0.06020	0.606
2.0	0.8990	100.00	0.274	0.171	-0.06110	0.610
2.1	0.8850	126.00	0.324	0.164	0.00301	0.644
2.2	0.8550	158.00	0.363	0.159	0.05190	0.674
2.3	0.8420	200.00	0.401	0.153	0.10200	0.700
2.4	0.8180	251.00	0.451	0.145	0.16700	0.735
2.5	0.7640	316.00	0.488	0.141	0.21100	0.765
2.6	0.7150	398.00	0.502	0.143	0.22200	0.781
2.7	0.6380	501.00	0.510	0.144	0.22800	0.792
2.8	0.5210	631.00	0.510	0.159	0.19800	0.822
2.9	0.4700	794.00	0.510	0.171	0.17600	0.845
3.0	0.4320	1000.00	0.510	0.174	0.17000	0.850
3.1	0.3450	1260.00	0.510	0.186	0.14500	0.875
3.2	0.2870	1580.00	0.510	0.206	0.10700	0.913
3.3	0.2200	2000.00	0.510	0.237	0.04520	0.975
3.4	0.1630	2510.00	0.510	0.357	-0.19000	1.210
3.5	0.1270	3160.00	0.510	0.562	-0.59100	1.610
3.6	0.0993	3980.00	0.510	0.646	-0.75600	1.780
3.7	0.0799	5010.00	0.510	0.629	-0.72400	1.740

IgG_gp70V1V2AP

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00595	0.000929	0.004130	0.00777
0.1	0.998	1.26	0.00583	0.001020	0.003840	0.00783
0.2	0.998	1.58	0.00583	0.001020	0.003840	0.00783
0.3	0.998	2.00	0.00583	0.001020	0.003840	0.00783
0.4	0.997	2.51	0.00583	0.001020	0.003830	0.00783
0.5	0.997	3.16	0.00583	0.001020	0.003830	0.00783
0.6	0.992	3.98	0.00583	0.001020	0.003830	0.00784
0.7	0.986	5.01	0.00583	0.001030	0.003820	0.00785
0.8	0.982	6.31	0.00583	0.001030	0.003810	0.00786
0.9	0.972	7.94	0.00583	0.001030	0.003820	0.00785
1.0	0.972	10.00	0.00583	0.001030	0.003820	0.00785
1.1	0.972	12.60	0.00583	0.001030	0.003820	0.00785
1.2	0.972	15.80	0.00583	0.001030	0.003820	0.00785
1.3	0.954	20.00	0.00583	0.001050	0.003780	0.00789
1.4	0.946	25.10	0.00583	0.001060	0.003760	0.00791
1.5	0.945	31.60	0.00583	0.001040	0.003790	0.00788
1.6	0.935	39.80	0.00583	0.001050	0.003770	0.00789
1.7	0.917	50.10	0.00553	0.001020	0.003520	0.00754
1.8	0.905	63.10	0.00553	0.001040	0.003490	0.00756
1.9	0.886	79.40	0.00515	0.000990	0.003210	0.00709
2.0	0.842	100.00	0.00515	0.001040	0.003110	0.00719
2.1	0.787	126.00	0.00514	0.001070	0.003050	0.00724
2.2	0.725	158.00	0.00511	0.001100	0.002950	0.00727
2.3	0.659	200.00	0.00491	0.001050	0.002860	0.00696
2.4	0.609	251.00	0.00491	0.001110	0.002740	0.00707
2.5	0.521	316.00	0.00491	0.001280	0.002400	0.00742
2.6	0.456	398.00	0.00491	0.001410	0.002140	0.00767
2.7	0.395	501.00	0.00491	0.001600	0.001780	0.00804
2.8	0.335	631.00	0.00491	0.001640	0.001690	0.00812
2.9	0.256	794.00	0.00491	0.001780	0.001420	0.00840
3.0	0.201	1000.00	0.00491	0.002390	0.000221	0.00959
3.1	0.170	1260.00	0.00491	0.002340	0.000324	0.00949
3.2	0.120	1580.00	0.00491	0.003520	-0.001990	0.01180
3.3	0.091	2000.00	0.00491	0.004630	-0.004170	0.01400

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00595	0.000929	0.003920	0.00797
0.1	1.26	0.998	0.00581	0.001020	0.003810	0.00780
0.2	1.58	0.998	0.00581	0.001020	0.003810	0.00780
0.3	2.00	0.998	0.00581	0.001020	0.003810	0.00780
0.4	2.51	0.997	0.00581	0.001020	0.003810	0.00781
0.5	3.16	0.997	0.00581	0.001020	0.003810	0.00781
0.6	3.98	0.992	0.00583	0.001020	0.003830	0.00784
0.7	5.01	0.986	0.00587	0.001030	0.003850	0.00788
0.8	6.31	0.982	0.00589	0.001030	0.003870	0.00792
0.9	7.94	0.972	0.00579	0.001030	0.003780	0.00780
1.0	10.00	0.972	0.00579	0.001030	0.003780	0.00780
1.1	12.60	0.972	0.00579	0.001030	0.003780	0.00780
1.2	15.80	0.972	0.00579	0.001030	0.003780	0.00780
1.3	20.00	0.954	0.00591	0.001050	0.003860	0.00797
1.4	25.10	0.946	0.00596	0.001060	0.003890	0.00804
1.5	31.60	0.945	0.00581	0.001040	0.003770	0.00785
1.6	39.80	0.935	0.00586	0.001050	0.003790	0.00792
1.7	50.10	0.917	0.00549	0.001020	0.003490	0.00750
1.8	63.10	0.905	0.00556	0.001040	0.003530	0.00760
1.9	79.40	0.886	0.00503	0.000990	0.003090	0.00697
2.0	100.00	0.842	0.00527	0.001040	0.003230	0.00730
2.1	126.00	0.787	0.00514	0.001070	0.003050	0.00724
2.2	158.00	0.725	0.00511	0.001100	0.002950	0.00727
2.3	200.00	0.659	0.00431	0.001050	0.002260	0.00636
2.4	251.00	0.609	0.00443	0.001110	0.002260	0.00660
2.5	316.00	0.521	0.00494	0.001280	0.002430	0.00745
2.6	398.00	0.456	0.00513	0.001410	0.002360	0.00789
2.7	501.00	0.395	0.00558	0.001600	0.002450	0.00870
2.8	631.00	0.335	0.00534	0.001640	0.002120	0.00855
2.9	794.00	0.256	0.00457	0.001780	0.001080	0.00806
3.0	1000.00	0.201	0.00596	0.002390	0.001280	0.01060
3.1	1260.00	0.170	0.00521	0.002340	0.000621	0.00979
3.2	1580.00	0.120	0.00703	0.003520	0.000132	0.01390
3.3	2000.00	0.091	0.00707	0.004630	-0.002010	0.01610

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.228	0.164	-0.09420	0.549
0.1	0.998	1.26	0.242	0.172	-0.09380	0.579
0.2	0.998	1.58	0.242	0.172	-0.09380	0.579
0.3	0.998	2.00	0.242	0.172	-0.09380	0.579
0.4	0.997	2.51	0.242	0.172	-0.09410	0.579
0.5	0.997	3.16	0.242	0.172	-0.09410	0.579
0.6	0.992	3.98	0.242	0.172	-0.09490	0.580
0.7	0.986	5.01	0.242	0.173	-0.09570	0.581
0.8	0.982	6.31	0.242	0.173	-0.09660	0.582
0.9	0.972	7.94	0.242	0.172	-0.09550	0.580
1.0	0.972	10.00	0.242	0.172	-0.09550	0.580
1.1	0.972	12.60	0.242	0.172	-0.09550	0.580
1.2	0.972	15.80	0.242	0.172	-0.09550	0.580
1.3	0.954	20.00	0.242	0.175	-0.09960	0.585
1.4	0.946	25.10	0.242	0.176	-0.10200	0.587
1.5	0.945	31.60	0.243	0.174	-0.09820	0.583
1.6	0.935	39.80	0.243	0.175	-0.10000	0.585
1.7	0.917	50.10	0.282	0.169	-0.04820	0.612
1.8	0.905	63.10	0.282	0.170	-0.05100	0.615
1.9	0.886	79.40	0.332	0.161	0.01670	0.647
2.0	0.842	100.00	0.332	0.166	0.00639	0.657
2.1	0.787	126.00	0.332	0.169	0.00131	0.663
2.2	0.725	158.00	0.336	0.172	-0.00141	0.673
2.3	0.659	200.00	0.363	0.164	0.04120	0.684
2.4	0.609	251.00	0.363	0.170	0.02860	0.697
2.5	0.521	316.00	0.363	0.190	-0.00970	0.735
2.6	0.456	398.00	0.363	0.205	-0.03900	0.764
2.7	0.395	501.00	0.363	0.227	-0.08170	0.807
2.8	0.335	631.00	0.363	0.232	-0.09180	0.817
2.9	0.256	794.00	0.363	0.249	-0.12500	0.850
3.0	0.201	1000.00	0.363	0.324	-0.27200	0.997
3.1	0.170	1260.00	0.363	0.317	-0.25900	0.985
3.2	0.120	1580.00	0.363	0.466	-0.55100	1.280
3.3	0.091	2000.00	0.363	0.608	-0.83000	1.560

IgG_gp70V1V2C

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00595	0.000929	0.004130	0.00777
0.1	0.9880	1.26	0.00592	0.001030	0.003900	0.00794
0.2	0.9880	1.58	0.00592	0.001030	0.003900	0.00794
0.3	0.9880	2.00	0.00592	0.001030	0.003900	0.00794
0.4	0.9860	2.51	0.00592	0.001030	0.003890	0.00795
0.5	0.9840	3.16	0.00592	0.001040	0.003890	0.00795
0.6	0.9840	3.98	0.00592	0.001040	0.003890	0.00795
0.7	0.9820	5.01	0.00592	0.001040	0.003890	0.00795
0.8	0.9820	6.31	0.00592	0.001040	0.003890	0.00795
0.9	0.9760	7.94	0.00592	0.001040	0.003880	0.00796
1.0	0.9660	10.00	0.00592	0.001050	0.003860	0.00798
1.1	0.9590	12.60	0.00592	0.001060	0.003840	0.00800
1.2	0.9530	15.80	0.00592	0.001050	0.003860	0.00798
1.3	0.9410	20.00	0.00592	0.001070	0.003830	0.00801
1.4	0.9310	25.10	0.00574	0.001050	0.003690	0.00779
1.5	0.9220	31.60	0.00553	0.001020	0.003520	0.00754
1.6	0.9080	39.80	0.00553	0.001040	0.003490	0.00756
1.7	0.9010	50.10	0.00510	0.000990	0.003160	0.00704
1.8	0.8820	63.10	0.00491	0.000981	0.002990	0.00683
1.9	0.8550	79.40	0.00473	0.000970	0.002830	0.00663
2.0	0.8310	100.00	0.00473	0.000978	0.002820	0.00665
2.1	0.7940	126.00	0.00473	0.001020	0.002730	0.00674
2.2	0.7360	158.00	0.00461	0.001020	0.002610	0.00661
2.3	0.6760	200.00	0.00461	0.001050	0.002540	0.00667
2.4	0.6180	251.00	0.00461	0.001160	0.002330	0.00689
2.5	0.5660	316.00	0.00454	0.001160	0.002270	0.00680
2.6	0.5210	398.00	0.00454	0.001220	0.002150	0.00693
2.7	0.4440	501.00	0.00389	0.001220	0.001500	0.00627
2.8	0.3780	631.00	0.00387	0.001340	0.001240	0.00649
2.9	0.3070	794.00	0.00387	0.001220	0.001470	0.00627
3.0	0.2510	1000.00	0.00387	0.001420	0.001080	0.00665
3.1	0.2010	1260.00	0.00387	0.001570	0.000784	0.00695
3.2	0.1310	1580.00	0.00387	0.002690	-0.001410	0.00914
3.3	0.0791	2000.00	0.00387	0.003750	-0.003490	0.01120

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00595	0.000929	0.003920	0.00797
0.1	1.26	0.9880	0.00588	0.001030	0.003850	0.00790
0.2	1.58	0.9880	0.00588	0.001030	0.003850	0.00790
0.3	2.00	0.9880	0.00588	0.001030	0.003850	0.00790
0.4	2.51	0.9860	0.00588	0.001030	0.003860	0.00791
0.5	3.16	0.9840	0.00589	0.001040	0.003860	0.00792
0.6	3.98	0.9840	0.00589	0.001040	0.003860	0.00792
0.7	5.01	0.9820	0.00591	0.001040	0.003870	0.00794
0.8	6.31	0.9820	0.00591	0.001040	0.003870	0.00794
0.9	7.94	0.9760	0.00594	0.001040	0.003900	0.00798
1.0	10.00	0.9660	0.00599	0.001050	0.003930	0.00805
1.1	12.60	0.9590	0.00603	0.001060	0.003950	0.00811
1.2	15.80	0.9530	0.00591	0.001050	0.003850	0.00797
1.3	20.00	0.9410	0.00599	0.001070	0.003900	0.00808
1.4	25.10	0.9310	0.00574	0.001050	0.003690	0.00779
1.5	31.60	0.9220	0.00550	0.001020	0.003490	0.00751
1.6	39.80	0.9080	0.00556	0.001040	0.003530	0.00760
1.7	50.10	0.9010	0.00510	0.000990	0.003160	0.00704
1.8	63.10	0.8820	0.00491	0.000981	0.002990	0.00683
1.9	79.40	0.8550	0.00470	0.000970	0.002800	0.00660
2.0	100.00	0.8310	0.00465	0.000978	0.002740	0.00657
2.1	126.00	0.7940	0.00485	0.001020	0.002840	0.00685
2.2	158.00	0.7360	0.00457	0.001020	0.002570	0.00656
2.3	200.00	0.6760	0.00442	0.001050	0.002350	0.00648
2.4	251.00	0.6180	0.00485	0.001160	0.002570	0.00713
2.5	316.00	0.5660	0.00449	0.001160	0.002220	0.00676
2.6	398.00	0.5210	0.00459	0.001220	0.002200	0.00698
2.7	501.00	0.4440	0.00389	0.001220	0.001500	0.00627
2.8	631.00	0.3780	0.00386	0.001340	0.001240	0.00649
2.9	794.00	0.3070	0.00298	0.001220	0.000584	0.00538
3.0	1000.00	0.2510	0.00320	0.001420	0.000419	0.00599
3.1	1260.00	0.2010	0.00325	0.001570	0.000169	0.00633
3.2	1580.00	0.1310	0.00496	0.002690	-0.000318	0.01020
3.3	2000.00	0.0791	0.00600	0.003750	-0.001360	0.01340

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.228	0.164	-0.0942	0.549
0.1	0.9880	1.26	0.231	0.174	-0.1100	0.572
0.2	0.9880	1.58	0.231	0.174	-0.1100	0.572
0.3	0.9880	2.00	0.231	0.174	-0.1100	0.572
0.4	0.9860	2.51	0.231	0.174	-0.1100	0.572
0.5	0.9840	3.16	0.231	0.174	-0.1100	0.573
0.6	0.9840	3.98	0.231	0.174	-0.1100	0.573
0.7	0.9820	5.01	0.231	0.175	-0.1110	0.573
0.8	0.9820	6.31	0.231	0.175	-0.1110	0.573
0.9	0.9760	7.94	0.231	0.175	-0.1110	0.574
1.0	0.9660	10.00	0.231	0.176	-0.1130	0.576
1.1	0.9590	12.60	0.231	0.177	-0.1150	0.577
1.2	0.9530	15.80	0.231	0.176	-0.1130	0.576
1.3	0.9410	20.00	0.231	0.177	-0.1160	0.579
1.4	0.9310	25.10	0.254	0.173	-0.0852	0.594
1.5	0.9220	31.60	0.282	0.169	-0.0485	0.613
1.6	0.9080	39.80	0.282	0.170	-0.0512	0.615
1.7	0.9010	50.10	0.337	0.160	0.0234	0.651
1.8	0.8820	63.10	0.362	0.157	0.0543	0.670
1.9	0.8550	79.40	0.385	0.154	0.0836	0.687
2.0	0.8310	100.00	0.385	0.155	0.0819	0.689
2.1	0.7940	126.00	0.385	0.160	0.0726	0.698
2.2	0.7360	158.00	0.402	0.158	0.0919	0.711
2.3	0.6760	200.00	0.402	0.162	0.0848	0.719
2.4	0.6180	251.00	0.402	0.174	0.0608	0.743
2.5	0.5660	316.00	0.411	0.172	0.0725	0.749
2.6	0.5210	398.00	0.411	0.180	0.0579	0.763
2.7	0.4440	501.00	0.495	0.174	0.1540	0.836
2.8	0.3780	631.00	0.498	0.189	0.1280	0.868
2.9	0.3070	794.00	0.498	0.175	0.1560	0.840
3.0	0.2510	1000.00	0.498	0.198	0.1090	0.887
3.1	0.2010	1260.00	0.498	0.217	0.0735	0.923
3.2	0.1310	1580.00	0.498	0.357	-0.2020	1.200
3.3	0.0791	2000.00	0.498	0.493	-0.4680	1.460

IgG_gp70BCaseA2V1V2169K

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00595	0.000929	0.004130	0.00777
0.1	0.9980	1.26	0.00584	0.001020	0.003840	0.00784
0.2	0.9980	1.58	0.00584	0.001020	0.003840	0.00784
0.3	0.9980	2.00	0.00584	0.001020	0.003840	0.00784
0.4	0.9970	2.51	0.00584	0.001020	0.003840	0.00784
0.5	0.9950	3.16	0.00584	0.001020	0.003840	0.00784
0.6	0.9950	3.98	0.00584	0.001020	0.003840	0.00784
0.7	0.9940	5.01	0.00584	0.001020	0.003830	0.00784
0.8	0.9940	6.31	0.00584	0.001020	0.003830	0.00784
0.9	0.9900	7.94	0.00584	0.001030	0.003830	0.00785
1.0	0.9890	10.00	0.00584	0.001030	0.003820	0.00785
1.1	0.9890	12.60	0.00584	0.001030	0.003820	0.00785
1.2	0.9890	15.80	0.00584	0.001030	0.003820	0.00785
1.3	0.9810	20.00	0.00584	0.001030	0.003810	0.00787
1.4	0.9740	25.10	0.00584	0.001040	0.003790	0.00788
1.5	0.9690	31.60	0.00582	0.001030	0.003800	0.00784
1.6	0.9650	39.80	0.00582	0.001040	0.003790	0.00784
1.7	0.9630	50.10	0.00569	0.001020	0.003690	0.00769
1.8	0.9580	63.10	0.00557	0.001010	0.003590	0.00755
1.9	0.9420	79.40	0.00536	0.000997	0.003410	0.00732
2.0	0.9420	100.00	0.00521	0.000981	0.003290	0.00713
2.1	0.9370	126.00	0.00510	0.000972	0.003190	0.00700
2.2	0.9190	158.00	0.00505	0.000979	0.003130	0.00697
2.3	0.8900	200.00	0.00470	0.000952	0.002830	0.00656
2.4	0.8720	251.00	0.00460	0.000948	0.002750	0.00646
2.5	0.8320	316.00	0.00449	0.000949	0.002630	0.00635
2.6	0.7830	398.00	0.00449	0.000985	0.002560	0.00642
2.7	0.7210	501.00	0.00449	0.001030	0.002480	0.00650
2.8	0.6690	631.00	0.00444	0.001060	0.002370	0.00652
2.9	0.6140	794.00	0.00438	0.001100	0.002230	0.00653
3.0	0.5430	1000.00	0.00433	0.001150	0.002070	0.00659
3.1	0.5020	1260.00	0.00433	0.001260	0.001850	0.00681
3.2	0.4000	1580.00	0.00432	0.001380	0.001600	0.00703
3.3	0.3380	2000.00	0.00425	0.001520	0.001280	0.00722
3.4	0.2650	2510.00	0.00425	0.001650	0.001030	0.00748
3.5	0.2050	3160.00	0.00425	0.002260	-0.000171	0.00868
3.6	0.1490	3980.00	0.00384	0.001680	0.000547	0.00714
3.7	0.1310	5010.00	0.00384	0.002150	-0.000370	0.00805
3.8	0.0971	6310.00	0.00384	0.002740	-0.001530	0.00921

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00595	0.000929	0.003920	0.00797
0.1	1.26	0.9980	0.00581	0.001020	0.003810	0.00780
0.2	1.58	0.9980	0.00581	0.001020	0.003810	0.00780
0.3	2.00	0.9980	0.00581	0.001020	0.003810	0.00780
0.4	2.51	0.9970	0.00581	0.001020	0.003810	0.00781
0.5	3.16	0.9950	0.00582	0.001020	0.003820	0.00782
0.6	3.98	0.9950	0.00582	0.001020	0.003820	0.00782
0.7	5.01	0.9940	0.00583	0.001020	0.003820	0.00783
0.8	6.31	0.9940	0.00583	0.001020	0.003820	0.00783
0.9	7.94	0.9900	0.00584	0.001030	0.003830	0.00785
1.0	10.00	0.9890	0.00585	0.001030	0.003840	0.00787
1.1	12.60	0.9890	0.00585	0.001030	0.003840	0.00787
1.2	15.80	0.9890	0.00585	0.001030	0.003840	0.00787
1.3	20.00	0.9810	0.00589	0.001030	0.003860	0.00791
1.4	25.10	0.9740	0.00592	0.001040	0.003880	0.00797
1.5	31.60	0.9690	0.00580	0.001030	0.003780	0.00782
1.6	39.80	0.9650	0.00583	0.001040	0.003800	0.00786
1.7	50.10	0.9630	0.00569	0.001020	0.003690	0.00769
1.8	63.10	0.9580	0.00557	0.001010	0.003590	0.00755
1.9	79.40	0.9420	0.00536	0.000997	0.003410	0.00732
2.0	100.00	0.9420	0.00521	0.000981	0.003290	0.00713
2.1	126.00	0.9370	0.00510	0.000972	0.003190	0.00700
2.2	158.00	0.9190	0.00505	0.000979	0.003130	0.00697
2.3	200.00	0.8900	0.00470	0.000952	0.002830	0.00656
2.4	251.00	0.8720	0.00460	0.000948	0.002750	0.00646
2.5	316.00	0.8320	0.00445	0.000949	0.002590	0.00631
2.6	398.00	0.7830	0.00451	0.000985	0.002580	0.00644
2.7	501.00	0.7210	0.00452	0.001030	0.002500	0.00653
2.8	631.00	0.6690	0.00444	0.001060	0.002370	0.00652
2.9	794.00	0.6140	0.00438	0.001100	0.002230	0.00653
3.0	1000.00	0.5430	0.00422	0.001150	0.001960	0.00648
3.1	1260.00	0.5020	0.00445	0.001260	0.001970	0.00693
3.2	1580.00	0.4000	0.00432	0.001380	0.001600	0.00703
3.3	2000.00	0.3380	0.00425	0.001520	0.001280	0.00722
3.4	2510.00	0.2650	0.00418	0.001650	0.000954	0.00740
3.5	3160.00	0.2050	0.00515	0.002260	0.000727	0.00958
3.6	3980.00	0.1490	0.00314	0.001680	-0.000156	0.00643
3.7	5010.00	0.1310	0.00397	0.002150	-0.000243	0.00818
3.8	6310.00	0.0971	0.00442	0.002740	-0.000948	0.00979

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.228	0.164	-0.09420	0.549
0.1	0.9980	1.26	0.242	0.172	-0.09450	0.578
0.2	0.9980	1.58	0.242	0.172	-0.09450	0.578
0.3	0.9980	2.00	0.242	0.172	-0.09450	0.578
0.4	0.9970	2.51	0.242	0.172	-0.09470	0.579
0.5	0.9950	3.16	0.242	0.172	-0.09500	0.579
0.6	0.9950	3.98	0.242	0.172	-0.09500	0.579
0.7	0.9940	5.01	0.242	0.172	-0.09530	0.579
0.8	0.9940	6.31	0.242	0.172	-0.09530	0.579
0.9	0.9900	7.94	0.242	0.172	-0.09590	0.580
1.0	0.9890	10.00	0.242	0.172	-0.09620	0.580
1.1	0.9890	12.60	0.242	0.172	-0.09620	0.580
1.2	0.9890	15.80	0.242	0.172	-0.09620	0.580
1.3	0.9810	20.00	0.242	0.173	-0.09760	0.581
1.4	0.9740	25.10	0.242	0.174	-0.09910	0.583
1.5	0.9690	31.60	0.245	0.173	-0.09330	0.583
1.6	0.9650	39.80	0.245	0.173	-0.09430	0.584
1.7	0.9630	50.10	0.261	0.170	-0.07260	0.594
1.8	0.9580	63.10	0.277	0.168	-0.05130	0.605
1.9	0.9420	79.40	0.304	0.164	-0.01770	0.625
2.0	0.9420	100.00	0.323	0.160	0.00888	0.638
2.1	0.9370	126.00	0.338	0.158	0.02790	0.648
2.2	0.9190	158.00	0.344	0.158	0.03360	0.655
2.3	0.8900	200.00	0.390	0.152	0.09260	0.687
2.4	0.8720	251.00	0.402	0.150	0.10800	0.697
2.5	0.8320	316.00	0.417	0.149	0.12500	0.709
2.6	0.7830	398.00	0.417	0.153	0.11700	0.717
2.7	0.7210	501.00	0.417	0.158	0.10800	0.726
2.8	0.6690	631.00	0.423	0.161	0.10800	0.738
2.9	0.6140	794.00	0.431	0.164	0.11000	0.753
3.0	0.5430	1000.00	0.437	0.170	0.10400	0.771
3.1	0.5020	1260.00	0.437	0.183	0.07850	0.796
3.2	0.4000	1580.00	0.439	0.197	0.05310	0.826
3.3	0.3380	2000.00	0.447	0.212	0.03140	0.864
3.4	0.2650	2510.00	0.447	0.228	0.00059	0.894
3.5	0.2050	3160.00	0.447	0.304	-0.14800	1.040
3.6	0.1490	3980.00	0.501	0.230	0.05070	0.952
3.7	0.1310	5010.00	0.501	0.288	-0.06360	1.070
3.8	0.0971	6310.00	0.501	0.363	-0.21000	1.210

IgG_gp70BCaseA2V1V2mut3

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00597	0.000929	0.00415	0.00779
0.1	0.997	1.26	0.00597	0.001030	0.00394	0.00799
0.2	0.997	1.58	0.00597	0.001030	0.00394	0.00799
0.3	0.997	2.00	0.00597	0.001030	0.00394	0.00799
0.4	0.997	2.51	0.00597	0.001030	0.00394	0.00799
0.5	0.997	3.16	0.00597	0.001030	0.00394	0.00799
0.6	0.995	3.98	0.00597	0.001040	0.00394	0.00800
0.7	0.994	5.01	0.00597	0.001040	0.00393	0.00800
0.8	0.994	6.31	0.00597	0.001040	0.00393	0.00800
0.9	0.992	7.94	0.00597	0.001040	0.00393	0.00800
1.0	0.992	10.00	0.00597	0.001040	0.00393	0.00800
1.1	0.992	12.60	0.00597	0.001040	0.00393	0.00800
1.2	0.992	15.80	0.00597	0.001040	0.00393	0.00800
1.3	0.992	20.00	0.00584	0.001020	0.00383	0.00785
1.4	0.992	25.10	0.00584	0.001020	0.00383	0.00785
1.5	0.992	31.60	0.00584	0.001020	0.00383	0.00785
1.6	0.990	39.80	0.00584	0.001030	0.00383	0.00785
1.7	0.990	50.10	0.00584	0.001030	0.00383	0.00785
1.8	0.990	63.10	0.00584	0.001030	0.00383	0.00785
1.9	0.990	79.40	0.00584	0.001030	0.00383	0.00785
2.0	0.990	100.00	0.00584	0.001030	0.00383	0.00785
2.1	0.990	126.00	0.00584	0.001030	0.00383	0.00785
2.2	0.990	158.00	0.00584	0.001030	0.00383	0.00785
2.3	0.989	200.00	0.00584	0.001030	0.00382	0.00786
2.4	0.987	251.00	0.00573	0.001020	0.00374	0.00772
2.5	0.987	316.00	0.00573	0.001020	0.00374	0.00772
2.6	0.987	398.00	0.00573	0.001020	0.00374	0.00772
2.7	0.987	501.00	0.00573	0.001020	0.00374	0.00772
2.8	0.981	631.00	0.00573	0.001020	0.00373	0.00773
2.9	0.981	794.00	0.00573	0.001020	0.00373	0.00773
3.0	0.981	1000.00	0.00562	0.001010	0.00365	0.00759
3.1	0.976	1260.00	0.00562	0.001010	0.00364	0.00760
3.2	0.976	1580.00	0.00549	0.000996	0.00354	0.00744
3.3	0.967	2000.00	0.00541	0.000990	0.00347	0.00735
3.4	0.963	2510.00	0.00541	0.000994	0.00346	0.00736
3.5	0.963	3160.00	0.00527	0.000978	0.00335	0.00719
3.6	0.956	3980.00	0.00519	0.000968	0.00329	0.00708
3.7	0.940	5010.00	0.00519	0.000939	0.00335	0.00702
3.8	0.922	6310.00	0.00519	0.000956	0.00331	0.00706
3.9	0.912	7940.00	0.00519	0.000969	0.00329	0.00708
4.0	0.830	10000.00	0.00519	0.001030	0.00316	0.00721
4.1	0.746	12600.00	0.00519	0.001130	0.00296	0.00741
4.2	0.673	15800.00	0.00519	0.001190	0.00284	0.00753
4.3	0.550	20000.00	0.00519	0.001410	0.00243	0.00794
4.4	0.323	25100.00	0.00519	0.001870	0.00152	0.00885

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00595	0.000929	0.00392	0.00797
0.1	1.26	0.997	0.00596	0.001030	0.00393	0.00799
0.2	1.58	0.997	0.00596	0.001030	0.00393	0.00799
0.3	2.00	0.997	0.00596	0.001030	0.00393	0.00799
0.4	2.51	0.997	0.00596	0.001030	0.00393	0.00799
0.5	3.16	0.997	0.00596	0.001030	0.00393	0.00799
0.6	3.98	0.995	0.00596	0.001040	0.00393	0.00800
0.7	5.01	0.994	0.00597	0.001040	0.00394	0.00800
0.8	6.31	0.994	0.00597	0.001040	0.00394	0.00800
0.9	7.94	0.992	0.00598	0.001040	0.00394	0.00802
1.0	10.00	0.992	0.00598	0.001040	0.00394	0.00802
1.1	12.60	0.992	0.00598	0.001040	0.00394	0.00802
1.2	15.80	0.992	0.00598	0.001040	0.00394	0.00802
1.3	20.00	0.992	0.00583	0.001020	0.00383	0.00784
1.4	25.10	0.992	0.00583	0.001020	0.00383	0.00784
1.5	31.60	0.992	0.00583	0.001020	0.00383	0.00784
1.6	39.80	0.990	0.00584	0.001030	0.00383	0.00785
1.7	50.10	0.990	0.00584	0.001030	0.00383	0.00785
1.8	63.10	0.990	0.00584	0.001030	0.00383	0.00785
1.9	79.40	0.990	0.00584	0.001030	0.00383	0.00785
2.0	100.00	0.990	0.00584	0.001030	0.00383	0.00785
2.1	126.00	0.990	0.00584	0.001030	0.00383	0.00785
2.2	158.00	0.990	0.00584	0.001030	0.00383	0.00785
2.3	200.00	0.989	0.00586	0.001030	0.00384	0.00787
2.4	251.00	0.987	0.00572	0.001020	0.00373	0.00771
2.5	316.00	0.987	0.00572	0.001020	0.00373	0.00771
2.6	398.00	0.987	0.00572	0.001020	0.00373	0.00771
2.7	501.00	0.987	0.00572	0.001020	0.00373	0.00771
2.8	631.00	0.981	0.00575	0.001020	0.00374	0.00775
2.9	794.00	0.981	0.00575	0.001020	0.00374	0.00775
3.0	1000.00	0.981	0.00560	0.001010	0.00363	0.00758
3.1	1260.00	0.976	0.00564	0.001010	0.00366	0.00762
3.2	1580.00	0.976	0.00549	0.000996	0.00354	0.00744
3.3	2000.00	0.967	0.00540	0.000990	0.00346	0.00734
3.4	2510.00	0.963	0.00542	0.000994	0.00347	0.00737
3.5	3160.00	0.963	0.00527	0.000978	0.00335	0.00719
3.6	3980.00	0.956	0.00515	0.000968	0.00325	0.00705
3.7	5010.00	0.940	0.00479	0.000939	0.00295	0.00663
3.8	6310.00	0.922	0.00487	0.000956	0.00300	0.00675
3.9	7940.00	0.912	0.00493	0.000969	0.00303	0.00683
4.0	10000.00	0.830	0.00507	0.001030	0.00305	0.00710
4.1	12600.00	0.746	0.00544	0.001130	0.00322	0.00766
4.2	15800.00	0.673	0.00541	0.001190	0.00307	0.00775
4.3	20000.00	0.550	0.00593	0.001410	0.00317	0.00868
4.4	25100.00	0.323	0.00536	0.001870	0.00170	0.00903

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.225	0.164	-0.096900	0.548
0.1	0.997	1.26	0.225	0.175	-0.117000	0.568
0.2	0.997	1.58	0.225	0.175	-0.117000	0.568
0.3	0.997	2.00	0.225	0.175	-0.117000	0.568
0.4	0.997	2.51	0.225	0.175	-0.117000	0.568
0.5	0.997	3.16	0.225	0.175	-0.117000	0.568
0.6	0.995	3.98	0.225	0.175	-0.117000	0.568
0.7	0.994	5.01	0.225	0.175	-0.118000	0.568
0.8	0.994	6.31	0.225	0.175	-0.118000	0.568
0.9	0.992	7.94	0.225	0.175	-0.118000	0.569
1.0	0.992	10.00	0.225	0.175	-0.118000	0.569
1.1	0.992	12.60	0.225	0.175	-0.118000	0.569
1.2	0.992	15.80	0.225	0.175	-0.118000	0.569
1.3	0.992	20.00	0.241	0.172	-0.096000	0.579
1.4	0.992	25.10	0.241	0.172	-0.096000	0.579
1.5	0.992	31.60	0.241	0.172	-0.096000	0.579
1.6	0.990	39.80	0.241	0.172	-0.096400	0.579
1.7	0.990	50.10	0.241	0.172	-0.096400	0.579
1.8	0.990	63.10	0.241	0.172	-0.096400	0.579
1.9	0.990	79.40	0.241	0.172	-0.096400	0.579
2.0	0.990	100.00	0.241	0.172	-0.096400	0.579
2.1	0.990	126.00	0.241	0.172	-0.096400	0.579
2.2	0.990	158.00	0.241	0.172	-0.096400	0.579
2.3	0.989	200.00	0.241	0.173	-0.096900	0.580
2.4	0.987	251.00	0.256	0.170	-0.076900	0.589
2.5	0.987	316.00	0.256	0.170	-0.076900	0.589
2.6	0.987	398.00	0.256	0.170	-0.076900	0.589
2.7	0.987	501.00	0.256	0.170	-0.076900	0.589
2.8	0.981	631.00	0.256	0.171	-0.078000	0.590
2.9	0.981	794.00	0.256	0.171	-0.078000	0.590
3.0	0.981	1000.00	0.270	0.168	-0.058700	0.599
3.1	0.976	1260.00	0.270	0.168	-0.059600	0.600
3.2	0.976	1580.00	0.287	0.165	-0.037100	0.611
3.3	0.967	2000.00	0.298	0.164	-0.023000	0.619
3.4	0.963	2510.00	0.298	0.164	-0.023800	0.619
3.5	0.963	3160.00	0.316	0.161	0.000465	0.631
3.6	0.956	3980.00	0.327	0.159	0.015300	0.638
3.7	0.940	5010.00	0.327	0.156	0.021300	0.632
3.8	0.922	6310.00	0.327	0.158	0.017800	0.636
3.9	0.912	7940.00	0.327	0.159	0.015200	0.638
4.0	0.830	10000.00	0.327	0.166	0.002090	0.651
4.1	0.746	12600.00	0.327	0.176	-0.019100	0.673
4.2	0.673	15800.00	0.327	0.183	-0.031900	0.685
4.3	0.550	20000.00	0.327	0.207	-0.078800	0.732
4.4	0.323	25100.00	0.327	0.262	-0.186000	0.839

IgG3_A244D11K169

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00596	0.000929	0.004140	0.00778
0.1	0.9940	1.26	0.00596	0.001040	0.003930	0.00799
0.2	0.9940	1.58	0.00586	0.001020	0.003850	0.00786
0.3	0.9940	2.00	0.00586	0.001020	0.003850	0.00786
0.4	0.9890	2.51	0.00586	0.001030	0.003840	0.00787
0.5	0.9880	3.16	0.00586	0.001030	0.003840	0.00788
0.6	0.9880	3.98	0.00586	0.001030	0.003840	0.00788
0.7	0.9860	5.01	0.00584	0.001020	0.003850	0.00783
0.8	0.9790	6.31	0.00584	0.001010	0.003870	0.00781
0.9	0.9790	7.94	0.00584	0.001010	0.003870	0.00781
1.0	0.9790	10.00	0.00584	0.001010	0.003870	0.00781
1.1	0.9670	12.60	0.00584	0.001020	0.003850	0.00784
1.2	0.9610	15.80	0.00584	0.001030	0.003830	0.00785
1.3	0.9520	20.00	0.00584	0.001020	0.003840	0.00784
1.4	0.9390	25.10	0.00584	0.001040	0.003810	0.00787
1.5	0.9200	31.60	0.00584	0.001060	0.003770	0.00791
1.6	0.9040	39.80	0.00584	0.001080	0.003730	0.00795
1.7	0.8800	50.10	0.00584	0.001090	0.003710	0.00798
1.8	0.8500	63.10	0.00584	0.001090	0.003700	0.00798
1.9	0.8010	79.40	0.00584	0.001150	0.003600	0.00809
2.0	0.7590	100.00	0.00584	0.001120	0.003640	0.00804
2.1	0.6720	126.00	0.00584	0.001150	0.003590	0.00809
2.2	0.5800	158.00	0.00584	0.001290	0.003320	0.00837
2.3	0.4950	200.00	0.00584	0.001550	0.002800	0.00888
2.4	0.3620	251.00	0.00584	0.001730	0.002440	0.00924
2.5	0.2880	316.00	0.00584	0.002090	0.001740	0.00995
2.6	0.2260	398.00	0.00584	0.002380	0.001180	0.01050
2.7	0.1860	501.00	0.00584	0.002690	0.000562	0.01110
2.8	0.1310	631.00	0.00584	0.003070	-0.000173	0.01190
2.9	0.0839	794.00	0.00584	0.004060	-0.002120	0.01380
3.0	0.0608	1000.00	0.00584	0.006410	-0.006720	0.01840
3.1	0.0519	1260.00	0.00584	0.006030	-0.005980	0.01770
3.2	0.0462	1580.00	0.00584	0.009500	-0.012800	0.02450
3.3	0.0285	2000.00	0.00584	0.024500	-0.042300	0.05390
3.4	0.0183	2510.00	0.00584	0.035600	-0.063800	0.07550
3.5	0.0093	3160.00	0.00584	0.049700	-0.091600	0.10300

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00595	0.000929	0.003920	0.00797
0.1	1.26	0.9940	0.00597	0.001040	0.003940	0.00801
0.2	1.58	0.9940	0.00583	0.001020	0.003820	0.00783
0.3	2.00	0.9940	0.00583	0.001020	0.003820	0.00783
0.4	2.51	0.9890	0.00587	0.001030	0.003850	0.00788
0.5	3.16	0.9880	0.00588	0.001030	0.003860	0.00790
0.6	3.98	0.9880	0.00588	0.001030	0.003860	0.00790
0.7	5.01	0.9860	0.00574	0.001020	0.003750	0.00773
0.8	6.31	0.9790	0.00562	0.001010	0.003650	0.00760
0.9	7.94	0.9790	0.00562	0.001010	0.003650	0.00760
1.0	10.00	0.9790	0.00562	0.001010	0.003650	0.00760
1.1	12.60	0.9670	0.00568	0.001020	0.003680	0.00768
1.2	15.80	0.9610	0.00573	0.001030	0.003710	0.00774
1.3	20.00	0.9520	0.00562	0.001020	0.003620	0.00762
1.4	25.10	0.9390	0.00571	0.001040	0.003680	0.00774
1.5	31.60	0.9200	0.00581	0.001060	0.003740	0.00788
1.6	39.80	0.9040	0.00591	0.001080	0.003800	0.00802
1.7	50.10	0.8800	0.00590	0.001090	0.003770	0.00804
1.8	63.10	0.8500	0.00576	0.001090	0.003620	0.00790
1.9	79.40	0.8010	0.00595	0.001150	0.003700	0.00819
2.0	100.00	0.7590	0.00549	0.001120	0.003290	0.00769
2.1	126.00	0.6720	0.00512	0.001150	0.002870	0.00738
2.2	158.00	0.5800	0.00545	0.001290	0.002920	0.00797
2.3	200.00	0.4950	0.00633	0.001550	0.003290	0.00937
2.4	251.00	0.3620	0.00599	0.001730	0.002600	0.00939
2.5	316.00	0.2880	0.00684	0.002090	0.002740	0.01090
2.6	398.00	0.2260	0.00716	0.002380	0.002490	0.01180
2.7	501.00	0.1860	0.00737	0.002690	0.002100	0.01270
2.8	631.00	0.1310	0.00692	0.003070	0.000906	0.01290
2.9	794.00	0.0839	0.00811	0.004060	0.000158	0.01610
3.0	1000.00	0.0608	0.00982	0.006410	-0.002740	0.02240
3.1	1260.00	0.0519	0.00935	0.006030	-0.002470	0.02120
3.2	1580.00	0.0462	0.01210	0.009500	-0.006540	0.03070
3.3	2000.00	0.0285	0.03600	0.024500	-0.012100	0.08410
3.4	2510.00	0.0183	0.07070	0.035600	0.001010	0.14000
3.5	3160.00	0.0093	0.14500	0.049700	0.047300	0.24200

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.226	0.164	-0.0960	0.548
0.1	0.9940	1.26	0.226	0.175	-0.1170	0.569
0.2	0.9940	1.58	0.240	0.172	-0.0982	0.577
0.3	0.9940	2.00	0.240	0.172	-0.0982	0.577
0.4	0.9890	2.51	0.240	0.173	-0.0991	0.578
0.5	0.9880	3.16	0.240	0.173	-0.0995	0.579
0.6	0.9880	3.98	0.240	0.173	-0.0995	0.579
0.7	0.9860	5.01	0.242	0.171	-0.0944	0.577
0.8	0.9790	6.31	0.242	0.170	-0.0926	0.576
0.9	0.9790	7.94	0.242	0.170	-0.0926	0.576
1.0	0.9790	10.00	0.242	0.170	-0.0926	0.576
1.1	0.9670	12.60	0.242	0.172	-0.0948	0.578
1.2	0.9610	15.80	0.242	0.173	-0.0966	0.580
1.3	0.9520	20.00	0.242	0.172	-0.0950	0.578
1.4	0.9390	25.10	0.242	0.173	-0.0984	0.581
1.5	0.9200	31.60	0.242	0.175	-0.1020	0.585
1.6	0.9040	39.80	0.242	0.177	-0.1060	0.589
1.7	0.8800	50.10	0.242	0.179	-0.1090	0.592
1.8	0.8500	63.10	0.242	0.179	-0.1090	0.592
1.9	0.8010	79.40	0.242	0.185	-0.1200	0.603
2.0	0.7590	100.00	0.242	0.182	-0.1160	0.599
2.1	0.6720	126.00	0.242	0.185	-0.1210	0.604
2.2	0.5800	158.00	0.242	0.200	-0.1500	0.633
2.3	0.4950	200.00	0.242	0.229	-0.2080	0.691
2.4	0.3620	251.00	0.242	0.250	-0.2490	0.732
2.5	0.2880	316.00	0.242	0.293	-0.3330	0.816
2.6	0.2260	398.00	0.242	0.328	-0.4010	0.884
2.7	0.1860	501.00	0.242	0.366	-0.4770	0.960
2.8	0.1310	631.00	0.242	0.413	-0.5680	1.050
2.9	0.0839	794.00	0.242	0.538	-0.8140	1.300
3.0	0.0608	1000.00	0.242	0.839	-1.4000	1.890
3.1	0.0519	1260.00	0.242	0.791	-1.3100	1.790
3.2	0.0462	1580.00	0.242	1.240	-2.1900	2.670
3.3	0.0285	2000.00	0.242	3.190	-6.0100	6.490
3.4	0.0183	2510.00	0.242	4.620	-8.8100	9.290
3.5	0.0093	3160.00	0.242	6.450	-12.4000	12.900

IgG3_gp70ClAEV1V2

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00595	0.000929	0.004130	0.00777
0.1	0.9850	1.26	0.00582	0.001010	0.003830	0.00780
0.2	0.9850	1.58	0.00582	0.001010	0.003830	0.00780
0.3	0.9850	2.00	0.00582	0.001010	0.003830	0.00780
0.4	0.9830	2.51	0.00582	0.001010	0.003830	0.00781
0.5	0.9820	3.16	0.00582	0.001020	0.003830	0.00781
0.6	0.9820	3.98	0.00582	0.001020	0.003830	0.00781
0.7	0.9820	5.01	0.00582	0.001020	0.003830	0.00781
0.8	0.9770	6.31	0.00582	0.001020	0.003820	0.00782
0.9	0.9730	7.94	0.00582	0.001030	0.003810	0.00783
1.0	0.9730	10.00	0.00582	0.001030	0.003810	0.00783
1.1	0.9660	12.60	0.00582	0.001030	0.003800	0.00784
1.2	0.9660	15.80	0.00582	0.001030	0.003800	0.00784
1.3	0.9660	20.00	0.00582	0.001030	0.003800	0.00784
1.4	0.9660	25.10	0.00582	0.001030	0.003800	0.00784
1.5	0.9620	31.60	0.00582	0.001030	0.003790	0.00785
1.6	0.9510	39.80	0.00582	0.001020	0.003830	0.00781
1.7	0.9470	50.10	0.00582	0.001020	0.003820	0.00782
1.8	0.9450	63.10	0.00582	0.001020	0.003820	0.00782
1.9	0.9360	79.40	0.00582	0.001030	0.003790	0.00785
2.0	0.9290	100.00	0.00582	0.001040	0.003780	0.00786
2.1	0.9100	126.00	0.00582	0.001030	0.003800	0.00784
2.2	0.8860	158.00	0.00582	0.001060	0.003730	0.00791
2.3	0.8750	200.00	0.00582	0.001080	0.003710	0.00793
2.4	0.8610	251.00	0.00582	0.001060	0.003750	0.00789
2.5	0.8310	316.00	0.00582	0.001070	0.003710	0.00792
2.6	0.8040	398.00	0.00582	0.001100	0.003670	0.00797
2.7	0.7140	501.00	0.00582	0.001190	0.003480	0.00816
2.8	0.6780	631.00	0.00582	0.001220	0.003420	0.00822
2.9	0.6350	794.00	0.00582	0.001260	0.003350	0.00829
3.0	0.5780	1000.00	0.00582	0.001360	0.003160	0.00848
3.1	0.5070	1260.00	0.00582	0.001470	0.002930	0.00871
3.2	0.4410	1580.00	0.00582	0.001640	0.002600	0.00904
3.3	0.3480	2000.00	0.00582	0.001840	0.002220	0.00942
3.4	0.3030	2510.00	0.00582	0.002060	0.001790	0.00985
3.5	0.2460	3160.00	0.00582	0.002450	0.001010	0.01060
3.6	0.1980	3980.00	0.00582	0.002820	0.000283	0.01140
3.7	0.1560	5010.00	0.00582	0.003560	-0.001160	0.01280
3.8	0.1080	6310.00	0.00582	0.004320	-0.002640	0.01430
3.9	0.0747	7940.00	0.00582	0.005710	-0.005380	0.01700
4.0	0.0655	10000.00	0.00582	0.006590	-0.007100	0.01870
4.1	0.0609	12600.00	0.00582	0.005650	-0.005260	0.01690
4.2	0.0451	15800.00	0.00582	0.007840	-0.009540	0.02120

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00595	0.000929	0.003920	0.00797
0.1	1.26	0.9850	0.00572	0.001010	0.003730	0.00770
0.2	1.58	0.9850	0.00572	0.001010	0.003730	0.00770
0.3	2.00	0.9850	0.00572	0.001010	0.003730	0.00770
0.4	2.51	0.9830	0.00573	0.001010	0.003740	0.00771
0.5	3.16	0.9820	0.00573	0.001020	0.003740	0.00772
0.6	3.98	0.9820	0.00573	0.001020	0.003740	0.00772
0.7	5.01	0.9820	0.00573	0.001020	0.003740	0.00772
0.8	6.31	0.9770	0.00576	0.001020	0.003760	0.00776
0.9	7.94	0.9730	0.00578	0.001030	0.003770	0.00779
1.0	10.00	0.9730	0.00578	0.001030	0.003770	0.00779
1.1	12.60	0.9660	0.00581	0.001030	0.003790	0.00784
1.2	15.80	0.9660	0.00581	0.001030	0.003790	0.00784
1.3	20.00	0.9660	0.00581	0.001030	0.003790	0.00784
1.4	25.10	0.9660	0.00581	0.001030	0.003790	0.00784
1.5	31.60	0.9620	0.00583	0.001030	0.003810	0.00786
1.6	39.80	0.9510	0.00560	0.001020	0.003610	0.00759
1.7	50.10	0.9470	0.00562	0.001020	0.003620	0.00762
1.8	63.10	0.9450	0.00563	0.001020	0.003630	0.00763
1.9	79.40	0.9360	0.00569	0.001030	0.003670	0.00772
2.0	100.00	0.9290	0.00573	0.001040	0.003690	0.00777
2.1	126.00	0.9100	0.00553	0.001030	0.003510	0.00755
2.2	158.00	0.8860	0.00569	0.001060	0.003610	0.00778
2.3	200.00	0.8750	0.00575	0.001080	0.003640	0.00786
2.4	251.00	0.8610	0.00551	0.001060	0.003440	0.00758
2.5	316.00	0.8310	0.00550	0.001070	0.003400	0.00761
2.6	398.00	0.8040	0.00553	0.001100	0.003380	0.00768
2.7	501.00	0.7140	0.00567	0.001190	0.003330	0.00802
2.8	631.00	0.6780	0.00574	0.001220	0.003340	0.00813
2.9	794.00	0.6350	0.00570	0.001260	0.003220	0.00817
3.0	1000.00	0.5780	0.00597	0.001360	0.003320	0.00863
3.1	1260.00	0.5070	0.00607	0.001470	0.003190	0.00896
3.2	1580.00	0.4410	0.00642	0.001640	0.003200	0.00965
3.3	2000.00	0.3480	0.00636	0.001840	0.002760	0.00996
3.4	2510.00	0.3030	0.00660	0.002060	0.002560	0.01060
3.5	3160.00	0.2460	0.00738	0.002450	0.002580	0.01220
3.6	3980.00	0.1980	0.00783	0.002820	0.002300	0.01340
3.7	5010.00	0.1560	0.00926	0.003560	0.002280	0.01620
3.8	6310.00	0.1080	0.00960	0.004320	0.001130	0.01810
3.9	7940.00	0.0747	0.01150	0.005710	0.000331	0.02270
4.0	10000.00	0.0655	0.01110	0.006590	-0.001830	0.02400
4.1	12600.00	0.0609	0.00847	0.005650	-0.002610	0.01950
4.2	15800.00	0.0451	0.01110	0.007840	-0.004290	0.02640

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.228	0.164	-0.0942	0.549
0.1	0.9850	1.26	0.244	0.171	-0.0904	0.579
0.2	0.9850	1.58	0.244	0.171	-0.0904	0.579
0.3	0.9850	2.00	0.244	0.171	-0.0904	0.579
0.4	0.9830	2.51	0.244	0.171	-0.0906	0.579
0.5	0.9820	3.16	0.244	0.171	-0.0909	0.580
0.6	0.9820	3.98	0.244	0.171	-0.0909	0.580
0.7	0.9820	5.01	0.244	0.171	-0.0909	0.580
0.8	0.9770	6.31	0.244	0.172	-0.0919	0.581
0.9	0.9730	7.94	0.244	0.172	-0.0929	0.582
1.0	0.9730	10.00	0.244	0.172	-0.0929	0.582
1.1	0.9660	12.60	0.244	0.173	-0.0942	0.583
1.2	0.9660	15.80	0.244	0.173	-0.0942	0.583
1.3	0.9660	20.00	0.244	0.173	-0.0942	0.583
1.4	0.9660	25.10	0.244	0.173	-0.0942	0.583
1.5	0.9620	31.60	0.244	0.173	-0.0947	0.583
1.6	0.9510	39.80	0.244	0.171	-0.0910	0.580
1.7	0.9470	50.10	0.244	0.172	-0.0919	0.581
1.8	0.9450	63.10	0.244	0.172	-0.0923	0.581
1.9	0.9360	79.40	0.244	0.173	-0.0947	0.583
2.0	0.9290	100.00	0.244	0.174	-0.0960	0.585
2.1	0.9100	126.00	0.244	0.173	-0.0940	0.583
2.2	0.8860	158.00	0.244	0.176	-0.1010	0.589
2.3	0.8750	200.00	0.244	0.177	-0.1030	0.592
2.4	0.8610	251.00	0.244	0.175	-0.0993	0.588
2.5	0.8310	316.00	0.244	0.177	-0.1030	0.591
2.6	0.8040	398.00	0.244	0.179	-0.1070	0.596
2.7	0.7140	501.00	0.244	0.190	-0.1270	0.616
2.8	0.6780	631.00	0.244	0.193	-0.1330	0.622
2.9	0.6350	794.00	0.244	0.197	-0.1410	0.630
3.0	0.5780	1000.00	0.244	0.207	-0.1610	0.650
3.1	0.5070	1260.00	0.244	0.220	-0.1870	0.676
3.2	0.4410	1580.00	0.244	0.240	-0.2260	0.714
3.3	0.3480	2000.00	0.244	0.262	-0.2700	0.758
3.4	0.3030	2510.00	0.244	0.289	-0.3210	0.810
3.5	0.2460	3160.00	0.244	0.336	-0.4150	0.904
3.6	0.1980	3980.00	0.244	0.383	-0.5060	0.994
3.7	0.1560	5010.00	0.244	0.475	-0.6870	1.180
3.8	0.1080	6310.00	0.244	0.571	-0.8750	1.360
3.9	0.0747	7940.00	0.244	0.750	-1.2300	1.710
4.0	0.0655	10000.00	0.244	0.863	-1.4500	1.940
4.1	0.0609	12600.00	0.244	0.742	-1.2100	1.700
4.2	0.0451	15800.00	0.244	1.020	-1.7600	2.250

IgG3_gp70V1V2A

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00611	0.000929	0.004280	0.00793
0.1	0.9280	1.26	0.00611	0.001090	0.003960	0.00825
0.2	0.9200	1.58	0.00611	0.001100	0.003950	0.00826
0.3	0.9180	2.00	0.00611	0.001100	0.003940	0.00827
0.4	0.9120	2.51	0.00607	0.001090	0.003920	0.00821
0.5	0.9100	3.16	0.00607	0.001100	0.003920	0.00821
0.6	0.8940	3.98	0.00602	0.001090	0.003880	0.00816
0.7	0.8810	5.01	0.00602	0.001110	0.003850	0.00819
0.8	0.8640	6.31	0.00598	0.001110	0.003810	0.00815
0.9	0.8450	7.94	0.00595	0.001120	0.003760	0.00814
1.0	0.8230	10.00	0.00548	0.001070	0.003380	0.00758
1.1	0.7770	12.60	0.00548	0.001120	0.003280	0.00768
1.2	0.7290	15.80	0.00533	0.001100	0.003170	0.00749
1.3	0.6790	20.00	0.00533	0.001140	0.003100	0.00756
1.4	0.5720	25.10	0.00533	0.001310	0.002770	0.00789
1.5	0.5260	31.60	0.00533	0.001340	0.002700	0.00796
1.6	0.4750	39.80	0.00533	0.001440	0.002510	0.00815
1.7	0.3890	50.10	0.00533	0.001610	0.002170	0.00849
1.8	0.3320	63.10	0.00533	0.001360	0.002660	0.00799
1.9	0.2540	79.40	0.00533	0.001760	0.001890	0.00877
2.0	0.2230	100.00	0.00533	0.002150	0.001120	0.00954
2.1	0.1870	126.00	0.00533	0.002260	0.000908	0.00975
2.2	0.1270	158.00	0.00533	0.003340	-0.001210	0.01190
2.3	0.1160	200.00	0.00533	0.003320	-0.001180	0.01180
2.4	0.1020	251.00	0.00533	0.003570	-0.001660	0.01230
2.5	0.0569	316.00	0.00533	0.008910	-0.012100	0.02280
2.6	0.0467	398.00	0.00533	0.026800	-0.047200	0.05780

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00595	0.000929	0.003920	0.00797
0.1	1.26	0.9280	0.00613	0.001090	0.003990	0.00827
0.2	1.58	0.9200	0.00617	0.001100	0.004010	0.00833
0.3	2.00	0.9180	0.00618	0.001100	0.004020	0.00834
0.4	2.51	0.9120	0.00606	0.001090	0.003920	0.00820
0.5	3.16	0.9100	0.00607	0.001100	0.003920	0.00822
0.6	3.98	0.8940	0.00598	0.001090	0.003840	0.00813
0.7	5.01	0.8810	0.00605	0.001110	0.003880	0.00823
0.8	6.31	0.8640	0.00598	0.001110	0.003810	0.00815
0.9	7.94	0.8450	0.00595	0.001120	0.003760	0.00814
1.0	10.00	0.8230	0.00541	0.001070	0.003310	0.00751
1.1	12.60	0.7770	0.00555	0.001120	0.003360	0.00775
1.2	15.80	0.7290	0.00511	0.001100	0.002950	0.00726
1.3	20.00	0.6790	0.00508	0.001140	0.002850	0.00731
1.4	25.10	0.5720	0.00543	0.001310	0.002870	0.00799
1.5	31.60	0.5260	0.00531	0.001340	0.002680	0.00793
1.6	39.80	0.4750	0.00553	0.001440	0.002710	0.00835
1.7	50.10	0.3890	0.00562	0.001610	0.002470	0.00878
1.8	63.10	0.3320	0.00358	0.001360	0.000915	0.00625
1.9	79.40	0.2540	0.00398	0.001760	0.000537	0.00742
2.0	100.00	0.2230	0.00481	0.002150	0.000599	0.00901
2.1	126.00	0.1870	0.00466	0.002260	0.000240	0.00908
2.2	158.00	0.1270	0.00640	0.003340	-0.000144	0.01290
2.3	200.00	0.1160	0.00576	0.003320	-0.000750	0.01230
2.4	251.00	0.1020	0.00539	0.003570	-0.001600	0.01240
2.5	316.00	0.0569	0.01170	0.008910	-0.005820	0.02910
2.6	398.00	0.0467	0.02270	0.026800	-0.029800	0.07520

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.207	0.166	-0.1180	0.533
0.1	0.9280	1.26	0.207	0.182	-0.1500	0.564
0.2	0.9200	1.58	0.207	0.183	-0.1520	0.566
0.3	0.9180	2.00	0.207	0.183	-0.1520	0.566
0.4	0.9120	2.51	0.212	0.182	-0.1440	0.569
0.5	0.9100	3.16	0.212	0.182	-0.1440	0.569
0.6	0.8940	3.98	0.218	0.181	-0.1370	0.574
0.7	0.8810	5.01	0.218	0.183	-0.1400	0.576
0.8	0.8640	6.31	0.224	0.182	-0.1340	0.581
0.9	0.8450	7.94	0.227	0.183	-0.1310	0.586
1.0	0.8230	10.00	0.288	0.173	-0.0503	0.627
1.1	0.7770	12.60	0.288	0.178	-0.0604	0.637
1.2	0.7290	15.80	0.308	0.174	-0.0336	0.650
1.3	0.6790	20.00	0.308	0.178	-0.0414	0.657
1.4	0.5720	25.10	0.308	0.197	-0.0778	0.694
1.5	0.5260	31.60	0.308	0.201	-0.0852	0.701
1.6	0.4750	39.80	0.308	0.212	-0.1070	0.723
1.7	0.3890	50.10	0.308	0.232	-0.1460	0.762
1.8	0.3320	63.10	0.308	0.203	-0.0895	0.705
1.9	0.2540	79.40	0.308	0.249	-0.1800	0.796
2.0	0.2230	100.00	0.308	0.296	-0.2720	0.888
2.1	0.1870	126.00	0.308	0.309	-0.2990	0.915
2.2	0.1270	158.00	0.308	0.445	-0.5640	1.180
2.3	0.1160	200.00	0.308	0.442	-0.5590	1.180
2.4	0.1020	251.00	0.308	0.474	-0.6210	1.240
2.5	0.0569	316.00	0.308	1.160	-1.9700	2.580
2.6	0.0467	398.00	0.308	3.480	-6.5100	7.130

IgG3_gp70V1V2AP

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00607	0.000929	0.004250	0.00789
0.1	0.9290	1.26	0.00607	0.001080	0.003960	0.00818
0.2	0.9290	1.58	0.00607	0.001080	0.003960	0.00818
0.3	0.9120	2.00	0.00607	0.001100	0.003920	0.00822
0.4	0.9010	2.51	0.00607	0.001100	0.003910	0.00823
0.5	0.8970	3.16	0.00590	0.001070	0.003790	0.00800
0.6	0.8710	3.98	0.00590	0.001100	0.003740	0.00805
0.7	0.8450	5.01	0.00590	0.001100	0.003750	0.00805
0.8	0.8290	6.31	0.00590	0.001120	0.003690	0.00810
0.9	0.7810	7.94	0.00590	0.001160	0.003630	0.00816
1.0	0.7400	10.00	0.00590	0.001150	0.003640	0.00816
1.1	0.7020	12.60	0.00590	0.001230	0.003480	0.00831
1.2	0.6360	15.80	0.00590	0.001340	0.003260	0.00853
1.3	0.5770	20.00	0.00590	0.001320	0.003300	0.00849
1.4	0.4680	25.10	0.00590	0.001530	0.002900	0.00890
1.5	0.4130	31.60	0.00544	0.001510	0.002490	0.00839
1.6	0.3350	39.80	0.00530	0.001640	0.002090	0.00851
1.7	0.2870	50.10	0.00530	0.001790	0.001790	0.00882
1.8	0.2140	63.10	0.00530	0.002290	0.000809	0.00979
1.9	0.1690	79.40	0.00530	0.003040	-0.000663	0.01130
2.0	0.1560	100.00	0.00530	0.003180	-0.000938	0.01150
2.1	0.1420	126.00	0.00530	0.003640	-0.001830	0.01240
2.2	0.1190	158.00	0.00530	0.004150	-0.002830	0.01340
2.3	0.0961	200.00	0.00530	0.005210	-0.004900	0.01550
2.4	0.0758	251.00	0.00530	0.006550	-0.007540	0.01810
2.5	0.0646	316.00	0.00530	0.004890	-0.004290	0.01490
2.6	0.0556	398.00	0.00530	0.006500	-0.007450	0.01810
2.7	0.0455	501.00	0.00530	0.006230	-0.006900	0.01750
2.8	0.0353	631.00	0.00530	0.009160	-0.012700	0.02330
2.9	0.0252	794.00	0.00530	0.018100	-0.030100	0.04070

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00595	0.000929	0.003920	0.00797
0.1	1.26	0.9290	0.00606	0.001080	0.003950	0.00817
0.2	1.58	0.9290	0.00606	0.001080	0.003950	0.00817
0.3	2.00	0.9120	0.00617	0.001100	0.004020	0.00833
0.4	2.51	0.9010	0.00612	0.001100	0.003950	0.00828
0.5	3.16	0.8970	0.00581	0.001070	0.003710	0.00791
0.6	3.98	0.8710	0.00594	0.001100	0.003790	0.00810
0.7	5.01	0.8450	0.00578	0.001100	0.003630	0.00793
0.8	6.31	0.8290	0.00591	0.001120	0.003700	0.00811
0.9	7.94	0.7810	0.00587	0.001160	0.003600	0.00813
1.0	10.00	0.7400	0.00560	0.001150	0.003340	0.00786
1.1	12.60	0.7020	0.00594	0.001230	0.003530	0.00835
1.2	15.80	0.6360	0.00634	0.001340	0.003710	0.00898
1.3	20.00	0.5770	0.00572	0.001320	0.003120	0.00831
1.4	25.10	0.4680	0.00611	0.001530	0.003110	0.00911
1.5	31.60	0.4130	0.00544	0.001510	0.002490	0.00839
1.6	39.80	0.3350	0.00515	0.001640	0.001940	0.00836
1.7	50.10	0.2870	0.00539	0.001790	0.001870	0.00890
1.8	63.10	0.2140	0.00616	0.002290	0.001670	0.01070
1.9	79.40	0.1690	0.00783	0.003040	0.001870	0.01380
2.0	100.00	0.1560	0.00718	0.003180	0.000937	0.01340
2.1	126.00	0.1420	0.00759	0.003640	0.000459	0.01470
2.2	158.00	0.1190	0.00735	0.004150	-0.000776	0.01550
2.3	200.00	0.0961	0.00877	0.005210	-0.001430	0.01900
2.4	251.00	0.0758	0.01080	0.006550	-0.002000	0.02370
2.5	316.00	0.0646	0.00747	0.004890	-0.002130	0.01710
2.6	398.00	0.0556	0.00727	0.006500	-0.005480	0.02000
2.7	501.00	0.0455	0.01210	0.006230	-0.000140	0.02430
2.8	631.00	0.0353	0.01700	0.009160	-0.000976	0.03490
2.9	794.00	0.0252	0.03020	0.018100	-0.005190	0.06560

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.212	0.166	-0.113	0.537
0.1	0.9290	1.26	0.212	0.180	-0.141	0.565
0.2	0.9290	1.58	0.212	0.180	-0.141	0.565
0.3	0.9120	2.00	0.212	0.182	-0.146	0.569
0.4	0.9010	2.51	0.212	0.183	-0.146	0.570
0.5	0.8970	3.16	0.234	0.178	-0.114	0.583
0.6	0.8710	3.98	0.234	0.180	-0.119	0.588
0.7	0.8450	5.01	0.234	0.180	-0.119	0.588
0.8	0.8290	6.31	0.234	0.183	-0.124	0.593
0.9	0.7810	7.94	0.234	0.186	-0.131	0.599
1.0	0.7400	10.00	0.234	0.186	-0.130	0.599
1.1	0.7020	12.60	0.234	0.194	-0.146	0.615
1.2	0.6360	15.80	0.234	0.207	-0.171	0.639
1.3	0.5770	20.00	0.234	0.204	-0.166	0.635
1.4	0.4680	25.10	0.234	0.227	-0.211	0.680
1.5	0.4130	31.60	0.294	0.221	-0.138	0.726
1.6	0.3350	39.80	0.312	0.235	-0.148	0.771
1.7	0.2870	50.10	0.312	0.253	-0.185	0.808
1.8	0.2140	63.10	0.312	0.314	-0.303	0.927
1.9	0.1690	79.40	0.312	0.407	-0.487	1.110
2.0	0.1560	100.00	0.312	0.425	-0.522	1.140
2.1	0.1420	126.00	0.312	0.483	-0.634	1.260
2.2	0.1190	158.00	0.312	0.548	-0.762	1.380
2.3	0.0961	200.00	0.312	0.683	-1.030	1.650
2.4	0.0758	251.00	0.312	0.857	-1.370	1.990
2.5	0.0646	316.00	0.312	0.643	-0.949	1.570
2.6	0.0556	398.00	0.312	0.850	-1.360	1.980
2.7	0.0455	501.00	0.312	0.815	-1.290	1.910
2.8	0.0353	631.00	0.312	1.190	-2.030	2.650
2.9	0.0252	794.00	0.312	2.350	-4.290	4.910

IgG3_gp70V1V2C

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00595	0.000929	0.004130	0.00777
0.1	0.9280	1.26	0.00529	0.000996	0.003330	0.00724
0.2	0.9260	1.58	0.00518	0.000980	0.003260	0.00711
0.3	0.9210	2.00	0.00518	0.000984	0.003260	0.00711
0.4	0.9170	2.51	0.00518	0.000992	0.003240	0.00713
0.5	0.9100	3.16	0.00518	0.001010	0.003210	0.00715
0.6	0.8940	3.98	0.00510	0.000991	0.003160	0.00705
0.7	0.8780	5.01	0.00510	0.001010	0.003130	0.00707
0.8	0.8540	6.31	0.00510	0.001010	0.003120	0.00709
0.9	0.8320	7.94	0.00510	0.001020	0.003110	0.00710
1.0	0.8040	10.00	0.00510	0.001040	0.003070	0.00714
1.1	0.7570	12.60	0.00510	0.001090	0.002970	0.00724
1.2	0.7220	15.80	0.00510	0.001100	0.002960	0.00725
1.3	0.6570	20.00	0.00510	0.001210	0.002730	0.00748
1.4	0.6130	25.10	0.00503	0.001140	0.002790	0.00726
1.5	0.5470	31.60	0.00503	0.001290	0.002500	0.00755
1.6	0.4920	39.80	0.00503	0.001330	0.002410	0.00764
1.7	0.4430	50.10	0.00503	0.001380	0.002320	0.00774
1.8	0.3570	63.10	0.00503	0.001640	0.001810	0.00824
1.9	0.3040	79.40	0.00503	0.001540	0.002010	0.00804
2.0	0.2730	100.00	0.00503	0.001530	0.002030	0.00803
2.1	0.2150	126.00	0.00503	0.001880	0.001350	0.00871
2.2	0.1780	158.00	0.00503	0.002290	0.000544	0.00951
2.3	0.1270	200.00	0.00503	0.003730	-0.002290	0.01230
2.4	0.0928	251.00	0.00503	0.004480	-0.003750	0.01380
2.5	0.0546	316.00	0.00503	0.009350	-0.013300	0.02340

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00595	0.000929	0.003920	0.00797
0.1	1.26	0.9280	0.00529	0.000996	0.003330	0.00724
0.2	1.58	0.9260	0.00514	0.000980	0.003210	0.00706
0.3	2.00	0.9210	0.00515	0.000984	0.003220	0.00708
0.4	2.51	0.9170	0.00519	0.000992	0.003250	0.00714
0.5	3.16	0.9100	0.00526	0.001010	0.003290	0.00723
0.6	3.98	0.8940	0.00504	0.000991	0.003090	0.00698
0.7	5.01	0.8780	0.00510	0.001010	0.003130	0.00707
0.8	6.31	0.8540	0.00506	0.001010	0.003080	0.00704
0.9	7.94	0.8320	0.00501	0.001020	0.003010	0.00701
1.0	10.00	0.8040	0.00502	0.001040	0.002990	0.00706
1.1	12.60	0.7570	0.00515	0.001090	0.003020	0.00728
1.2	15.80	0.7220	0.00500	0.001100	0.002850	0.00714
1.3	20.00	0.6570	0.00549	0.001210	0.003110	0.00786
1.4	25.10	0.6130	0.00466	0.001140	0.002420	0.00689
1.5	31.60	0.5470	0.00518	0.001290	0.002650	0.00770
1.6	39.80	0.4920	0.00508	0.001330	0.002470	0.00770
1.7	50.10	0.4430	0.00496	0.001380	0.002250	0.00767
1.8	63.10	0.3570	0.00531	0.001640	0.002100	0.00853
1.9	79.40	0.3040	0.00419	0.001540	0.001180	0.00720
2.0	100.00	0.2730	0.00372	0.001530	0.000721	0.00672
2.1	126.00	0.2150	0.00425	0.001880	0.000565	0.00793
2.2	158.00	0.1780	0.00510	0.002290	0.000622	0.00958
2.3	200.00	0.1270	0.00798	0.003730	0.000665	0.01530
2.4	251.00	0.0928	0.00754	0.004480	-0.001240	0.01630
2.5	316.00	0.0546	0.01220	0.009350	-0.006170	0.03050

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.228	0.164	-0.09420	0.549
0.1	0.9280	1.26	0.314	0.163	-0.00556	0.633
0.2	0.9260	1.58	0.327	0.160	0.01300	0.641
0.3	0.9210	2.00	0.327	0.160	0.01230	0.641
0.4	0.9170	2.51	0.327	0.161	0.01070	0.643
0.5	0.9100	3.16	0.327	0.163	0.00802	0.646
0.6	0.8940	3.98	0.337	0.160	0.02310	0.651
0.7	0.8780	5.01	0.337	0.162	0.02010	0.654
0.8	0.8540	6.31	0.337	0.163	0.01860	0.656
0.9	0.8320	7.94	0.337	0.163	0.01720	0.657
1.0	0.8040	10.00	0.337	0.165	0.01290	0.662
1.1	0.7570	12.60	0.337	0.171	0.00278	0.672
1.2	0.7220	15.80	0.337	0.171	0.00135	0.673
1.3	0.6570	20.00	0.337	0.184	-0.02390	0.698
1.4	0.6130	25.10	0.347	0.176	0.00315	0.692
1.5	0.5470	31.60	0.347	0.192	-0.02850	0.723
1.6	0.4920	39.80	0.347	0.197	-0.03900	0.734
1.7	0.4430	50.10	0.347	0.203	-0.05000	0.745
1.8	0.3570	63.10	0.347	0.233	-0.10900	0.804
1.9	0.3040	79.40	0.347	0.221	-0.08490	0.780
2.0	0.2730	100.00	0.347	0.220	-0.08360	0.778
2.1	0.2150	126.00	0.347	0.261	-0.16500	0.860
2.2	0.1780	158.00	0.347	0.311	-0.26300	0.958
2.3	0.1270	200.00	0.347	0.493	-0.62000	1.310
2.4	0.0928	251.00	0.347	0.589	-0.80700	1.500
2.5	0.0546	316.00	0.347	1.220	-2.04000	2.730

IgG3_gp70.V1V2CaseA2

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00595	0.000929	0.004130	0.00777
0.1	0.9400	1.26	0.00571	0.001040	0.003680	0.00775
0.2	0.9400	1.58	0.00571	0.001040	0.003680	0.00775
0.3	0.9350	2.00	0.00558	0.001030	0.003570	0.00759
0.4	0.9220	2.51	0.00555	0.001020	0.003550	0.00756
0.5	0.9080	3.16	0.00555	0.001040	0.003520	0.00759
0.6	0.8880	3.98	0.00555	0.001050	0.003500	0.00760
0.7	0.8690	5.01	0.00555	0.001070	0.003460	0.00765
0.8	0.8530	6.31	0.00549	0.001050	0.003420	0.00755
0.9	0.8230	7.94	0.00549	0.001090	0.003350	0.00762
1.0	0.7850	10.00	0.00545	0.001100	0.003300	0.00761
1.1	0.7310	12.60	0.00468	0.001010	0.002690	0.00666
1.2	0.6730	15.80	0.00468	0.001080	0.002570	0.00679
1.3	0.6550	20.00	0.00468	0.001110	0.002510	0.00685
1.4	0.5890	25.10	0.00468	0.001210	0.002300	0.00705
1.5	0.4950	31.60	0.00468	0.001280	0.002170	0.00719
1.6	0.4320	39.80	0.00468	0.001400	0.001930	0.00742
1.7	0.3540	50.10	0.00403	0.001400	0.001280	0.00678
1.8	0.3130	63.10	0.00403	0.001420	0.001250	0.00681
1.9	0.2540	79.40	0.00403	0.001580	0.000937	0.00712
2.0	0.2240	100.00	0.00403	0.001820	0.000460	0.00759
2.1	0.1580	126.00	0.00403	0.002630	-0.001140	0.00919
2.2	0.1150	158.00	0.00403	0.004010	-0.003840	0.01190
2.3	0.0712	200.00	0.00403	0.006370	-0.008460	0.01650
2.4	0.0578	251.00	0.00403	0.011200	-0.017900	0.02590

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00595	0.000929	0.003920	0.00797
0.1	1.26	0.9400	0.00571	0.001040	0.003680	0.00775
0.2	1.58	0.9400	0.00571	0.001040	0.003680	0.00775
0.3	2.00	0.9350	0.00558	0.001030	0.003570	0.00759
0.4	2.51	0.9220	0.00548	0.001020	0.003480	0.00749
0.5	3.16	0.9080	0.00556	0.001040	0.003530	0.00759
0.6	3.98	0.8880	0.00553	0.001050	0.003480	0.00758
0.7	5.01	0.8690	0.00564	0.001070	0.003540	0.00774
0.8	6.31	0.8530	0.00541	0.001050	0.003340	0.00747
0.9	7.94	0.8230	0.00557	0.001090	0.003430	0.00771
1.0	10.00	0.7850	0.00545	0.001100	0.003300	0.00761
1.1	12.60	0.7310	0.00446	0.001010	0.002470	0.00645
1.2	15.80	0.6730	0.00453	0.001080	0.002420	0.00664
1.3	20.00	0.6550	0.00465	0.001110	0.002480	0.00682
1.4	25.10	0.5890	0.00494	0.001210	0.002560	0.00732
1.5	31.60	0.4950	0.00464	0.001280	0.002130	0.00715
1.6	39.80	0.4320	0.00491	0.001400	0.002160	0.00765
1.7	50.10	0.3540	0.00400	0.001400	0.001250	0.00675
1.8	63.10	0.3130	0.00386	0.001420	0.001080	0.00664
1.9	79.40	0.2540	0.00385	0.001580	0.000762	0.00694
2.0	100.00	0.2240	0.00436	0.001820	0.000797	0.00793
2.1	126.00	0.1580	0.00574	0.002630	0.000580	0.01090
2.2	158.00	0.1150	0.00837	0.004010	0.000499	0.01620
2.3	200.00	0.0712	0.00974	0.006370	-0.002740	0.02220
2.4	251.00	0.0578	0.01450	0.011200	-0.007390	0.03640

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.228	0.164	-0.09420	0.549
0.1	0.9400	1.26	0.258	0.172	-0.07900	0.596
0.2	0.9400	1.58	0.258	0.172	-0.07900	0.596
0.3	0.9350	2.00	0.276	0.169	-0.05600	0.608
0.4	0.9220	2.51	0.279	0.169	-0.05150	0.609
0.5	0.9080	3.16	0.279	0.170	-0.05460	0.612
0.6	0.8880	3.98	0.279	0.171	-0.05650	0.614
0.7	0.8690	5.01	0.279	0.174	-0.06130	0.619
0.8	0.8530	6.31	0.287	0.171	-0.04790	0.623
0.9	0.8230	7.94	0.287	0.175	-0.05540	0.630
1.0	0.7850	10.00	0.292	0.176	-0.05250	0.636
1.1	0.7310	12.60	0.393	0.158	0.08290	0.703
1.2	0.6730	15.80	0.393	0.165	0.06960	0.716
1.3	0.6550	20.00	0.393	0.168	0.06280	0.723
1.4	0.5890	25.10	0.393	0.180	0.03960	0.746
1.5	0.4950	31.60	0.393	0.188	0.02440	0.761
1.6	0.4320	39.80	0.393	0.202	-0.00308	0.789
1.7	0.3540	50.10	0.477	0.197	0.09080	0.863
1.8	0.3130	63.10	0.477	0.199	0.08690	0.867
1.9	0.2540	79.40	0.477	0.218	0.04940	0.905
2.0	0.2240	100.00	0.477	0.248	-0.00922	0.963
2.1	0.1580	126.00	0.477	0.350	-0.21000	1.160
2.2	0.1150	158.00	0.477	0.527	-0.55500	1.510
2.3	0.0712	200.00	0.477	0.830	-1.15000	2.100
2.4	0.0578	251.00	0.477	1.450	-2.37000	3.330

IgG3_gp70BCaseA2V1V2169K

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00595	0.000929	0.004130	0.00777
0.1	0.9690	1.26	0.00544	0.000984	0.003510	0.00737
0.2	0.9690	1.58	0.00544	0.000984	0.003510	0.00737
0.3	0.9690	2.00	0.00544	0.000984	0.003510	0.00737
0.4	0.9690	2.51	0.00544	0.000984	0.003510	0.00737
0.5	0.9680	3.16	0.00544	0.000985	0.003510	0.00737
0.6	0.9630	3.98	0.00544	0.000989	0.003500	0.00738
0.7	0.9570	5.01	0.00544	0.000995	0.003490	0.00739
0.8	0.9320	6.31	0.00544	0.001020	0.003430	0.00745
0.9	0.9090	7.94	0.00544	0.001030	0.003410	0.00747
1.0	0.9000	10.00	0.00544	0.001040	0.003390	0.00748
1.1	0.8910	12.60	0.00531	0.001020	0.003320	0.00731
1.2	0.8790	15.80	0.00526	0.001010	0.003280	0.00725
1.3	0.8530	20.00	0.00526	0.001020	0.003260	0.00727
1.4	0.8270	25.10	0.00526	0.001060	0.003190	0.00734
1.5	0.7790	31.60	0.00526	0.001090	0.003130	0.00740
1.6	0.7450	39.80	0.00497	0.001070	0.002870	0.00707
1.7	0.7010	50.10	0.00488	0.001080	0.002760	0.00701
1.8	0.6550	63.10	0.00488	0.001130	0.002670	0.00710
1.9	0.6150	79.40	0.00488	0.001160	0.002610	0.00715
2.0	0.5360	100.00	0.00488	0.001260	0.002400	0.00736
2.1	0.4630	126.00	0.00488	0.001400	0.002150	0.00762
2.2	0.3790	158.00	0.00488	0.001520	0.001910	0.00785
2.3	0.3270	200.00	0.00439	0.001510	0.001430	0.00735
2.4	0.2760	251.00	0.00439	0.001790	0.000871	0.00791
2.5	0.2130	316.00	0.00439	0.002160	0.000153	0.00862
2.6	0.1640	398.00	0.00439	0.002530	-0.000568	0.00935
2.7	0.1200	501.00	0.00439	0.003680	-0.002820	0.01160
2.8	0.1060	631.00	0.00439	0.002920	-0.001330	0.01010
2.9	0.0781	794.00	0.00439	0.004290	-0.004020	0.01280
3.0	0.0658	1000.00	0.00439	0.003860	-0.003180	0.01200
3.1	0.0512	1260.00	0.00439	0.005710	-0.006800	0.01560

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00595	0.000929	0.003920	0.00797
0.1	1.26	0.9690	0.00537	0.000984	0.003440	0.00730
0.2	1.58	0.9690	0.00537	0.000984	0.003440	0.00730
0.3	2.00	0.9690	0.00537	0.000984	0.003440	0.00730
0.4	2.51	0.9690	0.00537	0.000984	0.003440	0.00730
0.5	3.16	0.9680	0.00538	0.000985	0.003440	0.00731
0.6	3.98	0.9630	0.00540	0.000989	0.003460	0.00733
0.7	5.01	0.9570	0.00542	0.000995	0.003470	0.00737
0.8	6.31	0.9320	0.00558	0.001020	0.003570	0.00758
0.9	7.94	0.9090	0.00555	0.001030	0.003520	0.00758
1.0	10.00	0.9000	0.00560	0.001040	0.003550	0.00764
1.1	12.60	0.8910	0.00531	0.001020	0.003320	0.00731
1.2	15.80	0.8790	0.00521	0.001010	0.003230	0.00719
1.3	20.00	0.8530	0.00519	0.001020	0.003180	0.00720
1.4	25.10	0.8270	0.00535	0.001060	0.003280	0.00743
1.5	31.60	0.7790	0.00531	0.001090	0.003170	0.00744
1.6	39.80	0.7450	0.00497	0.001070	0.002870	0.00707
1.7	50.10	0.7010	0.00474	0.001080	0.002610	0.00686
1.8	63.10	0.6550	0.00484	0.001130	0.002620	0.00705
1.9	79.40	0.6150	0.00474	0.001160	0.002460	0.00701
2.0	100.00	0.5360	0.00488	0.001260	0.002410	0.00736
2.1	126.00	0.4630	0.00520	0.001400	0.002470	0.00794
2.2	158.00	0.3790	0.00496	0.001520	0.001990	0.00794
2.3	200.00	0.3270	0.00437	0.001510	0.001420	0.00733
2.4	251.00	0.2760	0.00481	0.001790	0.001290	0.00832
2.5	316.00	0.2130	0.00539	0.002160	0.001150	0.00962
2.6	398.00	0.1640	0.00597	0.002530	0.001010	0.01090
2.7	501.00	0.1200	0.00827	0.003680	0.001060	0.01550
2.8	631.00	0.1060	0.00518	0.002920	-0.000537	0.01090
2.9	794.00	0.0781	0.00653	0.004290	-0.001870	0.01490
3.0	1000.00	0.0658	0.00518	0.003860	-0.002380	0.01280
3.1	1260.00	0.0512	0.00655	0.005710	-0.004640	0.01770

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.228	0.164	-0.09420	0.549
0.1	0.9690	1.26	0.294	0.163	-0.02620	0.614
0.2	0.9690	1.58	0.294	0.163	-0.02620	0.614
0.3	0.9690	2.00	0.294	0.163	-0.02620	0.614
0.4	0.9690	2.51	0.294	0.163	-0.02620	0.614
0.5	0.9680	3.16	0.294	0.164	-0.02660	0.614
0.6	0.9630	3.98	0.294	0.164	-0.02740	0.615
0.7	0.9570	5.01	0.294	0.164	-0.02840	0.616
0.8	0.9320	6.31	0.294	0.168	-0.03460	0.622
0.9	0.9090	7.94	0.294	0.169	-0.03650	0.624
1.0	0.9000	10.00	0.294	0.170	-0.03840	0.626
1.1	0.8910	12.60	0.310	0.165	-0.01390	0.634
1.2	0.8790	15.80	0.316	0.164	-0.00540	0.638
1.3	0.8530	20.00	0.316	0.166	-0.00799	0.641
1.4	0.8270	25.10	0.316	0.169	-0.01510	0.648
1.5	0.7790	31.60	0.316	0.172	-0.02120	0.654
1.6	0.7450	39.80	0.355	0.167	0.02660	0.683
1.7	0.7010	50.10	0.366	0.168	0.03710	0.695
1.8	0.6550	63.10	0.366	0.173	0.02720	0.705
1.9	0.6150	79.40	0.366	0.176	0.02080	0.711
2.0	0.5360	100.00	0.366	0.188	-0.00210	0.734
2.1	0.4630	126.00	0.366	0.203	-0.03180	0.764
2.2	0.3790	158.00	0.366	0.217	-0.05930	0.791
2.3	0.3270	200.00	0.430	0.213	0.01360	0.847
2.4	0.2760	251.00	0.430	0.247	-0.05420	0.914
2.5	0.2130	316.00	0.430	0.292	-0.14300	1.000
2.6	0.1640	398.00	0.430	0.339	-0.23300	1.090
2.7	0.1200	501.00	0.430	0.485	-0.52000	1.380
2.8	0.1060	631.00	0.430	0.387	-0.32900	1.190
2.9	0.0781	794.00	0.430	0.563	-0.67300	1.530
3.0	0.0658	1000.00	0.430	0.508	-0.56600	1.430
3.1	0.0512	1260.00	0.430	0.746	-1.03000	1.890

IgG3_gp70BCaseA2V1V2mut3

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00595	0.000929	0.004130	0.00777
0.1	0.9830	1.26	0.00584	0.001010	0.003850	0.00783
0.2	0.9830	1.58	0.00584	0.001010	0.003850	0.00783
0.3	0.9830	2.00	0.00584	0.001010	0.003850	0.00783
0.4	0.9830	2.51	0.00584	0.001010	0.003850	0.00783
0.5	0.9820	3.16	0.00584	0.001020	0.003850	0.00783
0.6	0.9820	3.98	0.00584	0.001020	0.003850	0.00783
0.7	0.9770	5.01	0.00584	0.001020	0.003840	0.00784
0.8	0.9770	6.31	0.00584	0.001020	0.003840	0.00784
0.9	0.9730	7.94	0.00584	0.001030	0.003830	0.00785
1.0	0.9730	10.00	0.00584	0.001030	0.003830	0.00785
1.1	0.9660	12.60	0.00584	0.001030	0.003820	0.00786
1.2	0.9660	15.80	0.00584	0.001030	0.003820	0.00786
1.3	0.9660	20.00	0.00584	0.001030	0.003820	0.00786
1.4	0.9560	25.10	0.00584	0.001040	0.003800	0.00788
1.5	0.9510	31.60	0.00584	0.001050	0.003790	0.00789
1.6	0.9470	39.80	0.00584	0.001020	0.003840	0.00784
1.7	0.9470	50.10	0.00584	0.001020	0.003840	0.00784
1.8	0.9360	63.10	0.00584	0.001030	0.003810	0.00787
1.9	0.9240	79.40	0.00584	0.001030	0.003820	0.00786
2.0	0.9100	100.00	0.00584	0.001030	0.003830	0.00786
2.1	0.8860	126.00	0.00584	0.001060	0.003760	0.00792
2.2	0.8660	158.00	0.00584	0.001070	0.003750	0.00794
2.3	0.8400	200.00	0.00584	0.001080	0.003720	0.00796
2.4	0.8310	251.00	0.00584	0.001070	0.003740	0.00795
2.5	0.8130	316.00	0.00584	0.001060	0.003770	0.00792
2.6	0.7360	398.00	0.00584	0.001090	0.003710	0.00797
2.7	0.6780	501.00	0.00584	0.001190	0.003510	0.00817
2.8	0.6200	631.00	0.00584	0.001290	0.003320	0.00836
2.9	0.5480	794.00	0.00584	0.001470	0.002970	0.00872
3.0	0.4750	1000.00	0.00584	0.001580	0.002740	0.00894
3.1	0.4220	1260.00	0.00584	0.001710	0.002500	0.00918
3.2	0.3250	1580.00	0.00584	0.002010	0.001910	0.00977
3.3	0.2650	2000.00	0.00584	0.002200	0.001530	0.01020
3.4	0.2370	2510.00	0.00584	0.002530	0.000891	0.01080
3.5	0.1710	3160.00	0.00584	0.003350	-0.000720	0.01240
3.6	0.1350	3980.00	0.00584	0.003950	-0.001910	0.01360
3.7	0.0950	5010.00	0.00584	0.004830	-0.003620	0.01530
3.8	0.0745	6310.00	0.00584	0.005310	-0.004560	0.01620
3.9	0.0654	7940.00	0.00584	0.005130	-0.004210	0.01590
4.0	0.0451	10000.00	0.00584	0.007840	-0.009520	0.02120
4.1	0.0451	12600.00	0.00584	0.007840	-0.009520	0.02120

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00595	0.000929	0.003920	0.00797
0.1	1.26	0.9830	0.00573	0.001010	0.003740	0.00771
0.2	1.58	0.9830	0.00573	0.001010	0.003740	0.00771
0.3	2.00	0.9830	0.00573	0.001010	0.003740	0.00771
0.4	2.51	0.9830	0.00573	0.001010	0.003740	0.00771
0.5	3.16	0.9820	0.00573	0.001020	0.003740	0.00772
0.6	3.98	0.9820	0.00573	0.001020	0.003740	0.00772
0.7	5.01	0.9770	0.00576	0.001020	0.003760	0.00776
0.8	6.31	0.9770	0.00576	0.001020	0.003760	0.00776
0.9	7.94	0.9730	0.00578	0.001030	0.003770	0.00779
1.0	10.00	0.9730	0.00578	0.001030	0.003770	0.00779
1.1	12.60	0.9660	0.00581	0.001030	0.003790	0.00784
1.2	15.80	0.9660	0.00581	0.001030	0.003790	0.00784
1.3	20.00	0.9660	0.00581	0.001030	0.003790	0.00784
1.4	25.10	0.9560	0.00587	0.001040	0.003830	0.00791
1.5	31.60	0.9510	0.00590	0.001050	0.003840	0.00795
1.6	39.80	0.9470	0.00562	0.001020	0.003620	0.00762
1.7	50.10	0.9470	0.00562	0.001020	0.003620	0.00762
1.8	63.10	0.9360	0.00569	0.001030	0.003670	0.00772
1.9	79.40	0.9240	0.00560	0.001030	0.003580	0.00761
2.0	100.00	0.9100	0.00552	0.001030	0.003500	0.00754
2.1	126.00	0.8860	0.00568	0.001060	0.003600	0.00776
2.2	158.00	0.8660	0.00564	0.001070	0.003540	0.00773
2.3	200.00	0.8400	0.00563	0.001080	0.003500	0.00775
2.4	251.00	0.8310	0.00550	0.001070	0.003400	0.00761
2.5	316.00	0.8130	0.00527	0.001060	0.003190	0.00734
2.6	398.00	0.7360	0.00503	0.001090	0.002900	0.00716
2.7	501.00	0.6780	0.00548	0.001190	0.003150	0.00781
2.8	631.00	0.6200	0.00579	0.001290	0.003270	0.00831
2.9	794.00	0.5480	0.00655	0.001470	0.003670	0.00942
3.0	1000.00	0.4750	0.00648	0.001580	0.003380	0.00959
3.1	1260.00	0.4220	0.00648	0.001710	0.003140	0.00982
3.2	1580.00	0.3250	0.00669	0.002010	0.002750	0.01060
3.3	2000.00	0.2650	0.00673	0.002200	0.002420	0.01100
3.4	2510.00	0.2370	0.00727	0.002530	0.002320	0.01220
3.5	3160.00	0.1710	0.00913	0.003350	0.002570	0.01570
3.6	3980.00	0.1350	0.00953	0.003950	0.001780	0.01730
3.7	5010.00	0.0950	0.00992	0.004830	0.000462	0.01940
3.8	6310.00	0.0745	0.01000	0.005310	-0.000403	0.02040
3.9	7940.00	0.0654	0.00763	0.005130	-0.002420	0.01770
4.0	10000.00	0.0451	0.01110	0.007840	-0.004290	0.02640
4.1	12600.00	0.0451	0.01110	0.007840	-0.004290	0.02640

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.228	0.164	-0.0942	0.549
0.1	0.9830	1.26	0.241	0.171	-0.0941	0.577
0.2	0.9830	1.58	0.241	0.171	-0.0941	0.577
0.3	0.9830	2.00	0.241	0.171	-0.0941	0.577
0.4	0.9830	2.51	0.241	0.171	-0.0941	0.577
0.5	0.9820	3.16	0.241	0.171	-0.0943	0.577
0.6	0.9820	3.98	0.241	0.171	-0.0943	0.577
0.7	0.9770	5.01	0.241	0.172	-0.0953	0.578
0.8	0.9770	6.31	0.241	0.172	-0.0953	0.578
0.9	0.9730	7.94	0.241	0.172	-0.0963	0.579
1.0	0.9730	10.00	0.241	0.172	-0.0963	0.579
1.1	0.9660	12.60	0.241	0.173	-0.0976	0.580
1.2	0.9660	15.80	0.241	0.173	-0.0976	0.580
1.3	0.9660	20.00	0.241	0.173	-0.0976	0.580
1.4	0.9560	25.10	0.241	0.174	-0.0994	0.582
1.5	0.9510	31.60	0.241	0.174	-0.1000	0.583
1.6	0.9470	39.80	0.241	0.172	-0.0953	0.578
1.7	0.9470	50.10	0.241	0.172	-0.0953	0.578
1.8	0.9360	63.10	0.241	0.173	-0.0981	0.581
1.9	0.9240	79.40	0.241	0.173	-0.0970	0.580
2.0	0.9100	100.00	0.241	0.173	-0.0969	0.580
2.1	0.8860	126.00	0.241	0.176	-0.1030	0.586
2.2	0.8660	158.00	0.241	0.177	-0.1050	0.588
2.3	0.8400	200.00	0.241	0.178	-0.1080	0.591
2.4	0.8310	251.00	0.241	0.177	-0.1060	0.589
2.5	0.8130	316.00	0.241	0.176	-0.1030	0.586
2.6	0.7360	398.00	0.241	0.179	-0.1090	0.591
2.7	0.6780	501.00	0.241	0.189	-0.1290	0.612
2.8	0.6200	631.00	0.241	0.200	-0.1500	0.633
2.9	0.5480	794.00	0.241	0.220	-0.1890	0.672
3.0	0.4750	1000.00	0.241	0.233	-0.2150	0.698
3.1	0.4220	1260.00	0.241	0.247	-0.2430	0.725
3.2	0.3250	1580.00	0.241	0.283	-0.3120	0.795
3.3	0.2650	2000.00	0.241	0.306	-0.3580	0.841
3.4	0.2370	2510.00	0.241	0.346	-0.4360	0.919
3.5	0.1710	3160.00	0.241	0.448	-0.6370	1.120
3.6	0.1350	3980.00	0.241	0.525	-0.7870	1.270
3.7	0.0950	5010.00	0.241	0.636	-1.0100	1.490
3.8	0.0745	6310.00	0.241	0.698	-1.1300	1.610
3.9	0.0654	7940.00	0.241	0.675	-1.0800	1.560
4.0	0.0451	10000.00	0.241	1.020	-1.7600	2.250
4.1	0.0451	12600.00	0.241	1.020	-1.7600	2.250

Combined HVTN 705 + RV144 analyses (24 month)

• Adjustment covariates: Region (RV144, South Africa, Outside South Africa), age above or below 26
• Event time variable: HIVwk26fu (RV144) and Ttilde.D210 (HVTN 705)
• Event type variable: HIVwk26 (RV144) and Delta.D210 (HVTN 705)
• Weight variable: sample_weight (RV144) and wt.D210 (HVTN 705)
• Reference timepoint: 459 days (earliest between RV144 and HVTN 705)
• Filter for HVTN 705: !is.na(Ttilde.D210)
• All learners: GLM

IgG V1V2 B.CaseA-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00871	0.00104	6.67e-03	0.01070
0.1	0.9830	1.26	0.00871	0.00122	6.32e-03	0.01110
0.2	0.9830	1.58	0.00871	0.00122	6.32e-03	0.01110
0.3	0.9830	2.00	0.00871	0.00122	6.32e-03	0.01110
0.4	0.9820	2.51	0.00871	0.00122	6.32e-03	0.01110
0.5	0.9820	3.16	0.00871	0.00122	6.32e-03	0.01110
0.6	0.9820	3.98	0.00871	0.00122	6.32e-03	0.01110
0.7	0.9820	5.01	0.00871	0.00122	6.32e-03	0.01110
0.8	0.9800	6.31	0.00871	0.00122	6.32e-03	0.01110
0.9	0.9800	7.94	0.00871	0.00122	6.32e-03	0.01110
1.0	0.9780	10.00	0.00871	0.00122	6.32e-03	0.01110
1.1	0.9760	12.60	0.00871	0.00122	6.31e-03	0.01110
1.2	0.9690	15.80	0.00871	0.00124	6.28e-03	0.01110
1.3	0.9620	20.00	0.00871	0.00124	6.27e-03	0.01110
1.4	0.9600	25.10	0.00871	0.00123	6.29e-03	0.01110
1.5	0.9540	31.60	0.00871	0.00125	6.26e-03	0.01120
1.6	0.9450	39.80	0.00871	0.00126	6.24e-03	0.01120
1.7	0.9380	50.10	0.00855	0.00125	6.09e-03	0.01100
1.8	0.9170	63.10	0.00831	0.00125	5.86e-03	0.01070
1.9	0.9150	79.40	0.00805	0.00122	5.65e-03	0.01050
2.0	0.9020	100.00	0.00805	0.00124	5.61e-03	0.01050
2.1	0.8880	126.00	0.00792	0.00123	5.51e-03	0.01030
2.2	0.8650	158.00	0.00792	0.00125	5.47e-03	0.01040
2.3	0.8160	200.00	0.00792	0.00125	5.47e-03	0.01040
2.4	0.7780	251.00	0.00792	0.00129	5.39e-03	0.01050
2.5	0.7250	316.00	0.00792	0.00131	5.35e-03	0.01050
2.6	0.6690	398.00	0.00792	0.00134	5.30e-03	0.01060
2.7	0.6130	501.00	0.00792	0.00145	5.08e-03	0.01080
2.8	0.5240	631.00	0.00792	0.00156	4.87e-03	0.01100
2.9	0.4900	794.00	0.00792	0.00157	4.84e-03	0.01100
3.0	0.4190	1000.00	0.00730	0.00155	4.26e-03	0.01030
3.1	0.3610	1260.00	0.00685	0.00160	3.72e-03	0.00999
3.2	0.2960	1580.00	0.00676	0.00168	3.47e-03	0.01000
3.3	0.2260	2000.00	0.00676	0.00198	2.88e-03	0.01060
3.4	0.1870	2510.00	0.00668	0.00217	2.42e-03	0.01090
3.5	0.1560	3160.00	0.00668	0.00209	2.57e-03	0.01080
3.6	0.1250	3980.00	0.00668	0.00298	8.43e-04	0.01250
3.7	0.0969	5010.00	0.00668	0.00325	3.00e-04	0.01310
3.8	0.0671	6310.00	0.00481	0.00180	1.29e-03	0.00833
3.9	0.0547	7940.00	0.00481	0.00184	1.20e-03	0.00842
4.0	0.0447	10000.00	0.00481	0.00247	-3.97e-05	0.00966
4.1	0.0379	12600.00	0.00481	0.00303	-1.13e-03	0.01080
4.2	0.0306	15800.00	0.00481	0.00323	-1.52e-03	0.01110
4.3	0.0225	20000.00	0.00409	0.00272	-1.25e-03	0.00943

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00870	0.00104	0.006720	0.01150
0.1	1.26	0.9830	0.00867	0.00122	0.006280	0.01110
0.2	1.58	0.9830	0.00867	0.00122	0.006280	0.01110
0.3	2.00	0.9830	0.00867	0.00122	0.006280	0.01110
0.4	2.51	0.9820	0.00868	0.00122	0.006290	0.01110
0.5	3.16	0.9820	0.00868	0.00122	0.006290	0.01110
0.6	3.98	0.9820	0.00868	0.00122	0.006290	0.01110
0.7	5.01	0.9820	0.00868	0.00122	0.006290	0.01110
0.8	6.31	0.9800	0.00868	0.00122	0.006290	0.01110
0.9	7.94	0.9800	0.00868	0.00122	0.006290	0.01110
1.0	10.00	0.9780	0.00869	0.00122	0.006300	0.01110
1.1	12.60	0.9760	0.00871	0.00122	0.006310	0.01110
1.2	15.80	0.9690	0.00881	0.00124	0.006380	0.01120
1.3	20.00	0.9620	0.00883	0.00124	0.006400	0.01130
1.4	25.10	0.9600	0.00871	0.00123	0.006290	0.01110
1.5	31.60	0.9540	0.00879	0.00125	0.006340	0.01120
1.6	39.80	0.9450	0.00877	0.00126	0.006300	0.01120
1.7	50.10	0.9380	0.00855	0.00125	0.006090	0.01100
1.8	63.10	0.9170	0.00831	0.00125	0.005860	0.01070
1.9	79.40	0.9150	0.00804	0.00122	0.005640	0.01040
2.0	100.00	0.9020	0.00806	0.00124	0.005620	0.01050
2.1	126.00	0.8880	0.00786	0.00123	0.005450	0.01030
2.2	158.00	0.8650	0.00790	0.00125	0.005450	0.01030
2.3	200.00	0.8160	0.00772	0.00125	0.005270	0.01020
2.4	251.00	0.7780	0.00779	0.00129	0.005260	0.01030
2.5	316.00	0.7250	0.00779	0.00131	0.005210	0.01040
2.6	398.00	0.6690	0.00759	0.00134	0.004970	0.01020
2.7	501.00	0.6130	0.00811	0.00145	0.005260	0.01100
2.8	631.00	0.5240	0.00845	0.00156	0.005400	0.01150
2.9	794.00	0.4900	0.00821	0.00157	0.005120	0.01130
3.0	1000.00	0.4190	0.00730	0.00155	0.004260	0.01030
3.1	1260.00	0.3610	0.00685	0.00160	0.003720	0.00999
3.2	1580.00	0.2960	0.00669	0.00168	0.003400	0.00998
3.3	2000.00	0.2260	0.00684	0.00198	0.002960	0.01070
3.4	2510.00	0.1870	0.00661	0.00217	0.002350	0.01090
3.5	3160.00	0.1560	0.00602	0.00209	0.001910	0.01010
3.6	3980.00	0.1250	0.00693	0.00298	0.001090	0.01280
3.7	5010.00	0.0969	0.00725	0.00325	0.000876	0.01360
3.8	6310.00	0.0671	0.00429	0.00180	0.000771	0.00781
3.9	7940.00	0.0547	0.00381	0.00184	0.000201	0.00742
4.0	10000.00	0.0447	0.00513	0.00247	0.000282	0.00998
4.1	12600.00	0.0379	0.00553	0.00303	-0.000410	0.01150
4.2	15800.00	0.0306	0.00528	0.00323	-0.001040	0.01160
4.3	20000.00	0.0225	0.00409	0.00272	-0.001250	0.00943

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.289	0.113	0.0671	0.510
0.1	0.9830	1.26	0.289	0.124	0.0447	0.532
0.2	0.9830	1.58	0.289	0.124	0.0447	0.532
0.3	0.9830	2.00	0.289	0.124	0.0447	0.532
0.4	0.9820	2.51	0.289	0.124	0.0446	0.533
0.5	0.9820	3.16	0.289	0.124	0.0446	0.533
0.6	0.9820	3.98	0.289	0.124	0.0446	0.533
0.7	0.9820	5.01	0.289	0.124	0.0446	0.533
0.8	0.9800	6.31	0.289	0.125	0.0445	0.533
0.9	0.9800	7.94	0.289	0.125	0.0445	0.533
1.0	0.9780	10.00	0.289	0.125	0.0444	0.533
1.1	0.9760	12.60	0.289	0.125	0.0440	0.533
1.2	0.9690	15.80	0.289	0.126	0.0420	0.535
1.3	0.9620	20.00	0.289	0.126	0.0415	0.536
1.4	0.9600	25.10	0.289	0.125	0.0427	0.535
1.5	0.9540	31.60	0.289	0.126	0.0407	0.536
1.6	0.9450	39.80	0.289	0.127	0.0397	0.538
1.7	0.9380	50.10	0.302	0.126	0.0553	0.549
1.8	0.9170	63.10	0.322	0.124	0.0782	0.565
1.9	0.9150	79.40	0.343	0.122	0.1040	0.581
2.0	0.9020	100.00	0.343	0.123	0.1020	0.583
2.1	0.8880	126.00	0.353	0.121	0.1150	0.591
2.2	0.8650	158.00	0.353	0.123	0.1130	0.593
2.3	0.8160	200.00	0.353	0.123	0.1120	0.594
2.4	0.7780	251.00	0.353	0.125	0.1070	0.599
2.5	0.7250	316.00	0.353	0.127	0.1040	0.602
2.6	0.6690	398.00	0.353	0.129	0.1000	0.605
2.7	0.6130	501.00	0.353	0.137	0.0849	0.621
2.8	0.5240	631.00	0.353	0.144	0.0698	0.636
2.9	0.4900	794.00	0.353	0.145	0.0679	0.638
3.0	0.4190	1000.00	0.404	0.141	0.1270	0.681
3.1	0.3610	1260.00	0.440	0.143	0.1590	0.721
3.2	0.2960	1580.00	0.448	0.149	0.1560	0.740
3.3	0.2260	2000.00	0.448	0.172	0.1110	0.784
3.4	0.1870	2510.00	0.455	0.187	0.0888	0.820
3.5	0.1560	3160.00	0.455	0.180	0.1010	0.808
3.6	0.1250	3980.00	0.455	0.250	-0.0352	0.944
3.7	0.0969	5010.00	0.455	0.272	-0.0784	0.987
3.8	0.0671	6310.00	0.607	0.152	0.3090	0.906
3.9	0.0547	7940.00	0.607	0.156	0.3020	0.913
4.0	0.0447	10000.00	0.607	0.206	0.2030	1.010
4.1	0.0379	12600.00	0.607	0.251	0.1150	1.100
4.2	0.0306	15800.00	0.607	0.267	0.0844	1.130
4.3	0.0225	20000.00	0.666	0.225	0.2250	1.110

IgG V1V2 AE.A244-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00899	0.001040	6.96e-03	0.01100
0.1	0.995	1.26	0.00899	0.001210	6.61e-03	0.01140
0.2	0.995	1.58	0.00899	0.001210	6.61e-03	0.01140
0.3	0.995	2.00	0.00899	0.001210	6.61e-03	0.01140
0.4	0.995	2.51	0.00899	0.001210	6.61e-03	0.01140
0.5	0.995	3.16	0.00899	0.001210	6.61e-03	0.01140
0.6	0.995	3.98	0.00899	0.001210	6.61e-03	0.01140
0.7	0.994	5.01	0.00899	0.001200	6.63e-03	0.01130
0.8	0.992	6.31	0.00899	0.001200	6.63e-03	0.01130
0.9	0.992	7.94	0.00899	0.001190	6.65e-03	0.01130
1.0	0.992	10.00	0.00899	0.001190	6.65e-03	0.01130
1.1	0.992	12.60	0.00899	0.001190	6.66e-03	0.01130
1.2	0.991	15.80	0.00899	0.001190	6.65e-03	0.01130
1.3	0.991	20.00	0.00899	0.001190	6.65e-03	0.01130
1.4	0.990	25.10	0.00899	0.001190	6.65e-03	0.01130
1.5	0.989	31.60	0.00899	0.001200	6.63e-03	0.01130
1.6	0.989	39.80	0.00899	0.001200	6.63e-03	0.01130
1.7	0.989	50.10	0.00899	0.001210	6.62e-03	0.01130
1.8	0.986	63.10	0.00899	0.001220	6.60e-03	0.01140
1.9	0.985	79.40	0.00899	0.001220	6.59e-03	0.01140
2.0	0.985	100.00	0.00899	0.001210	6.61e-03	0.01140
2.1	0.979	126.00	0.00899	0.001230	6.57e-03	0.01140
2.2	0.972	158.00	0.00899	0.001250	6.53e-03	0.01140
2.3	0.970	200.00	0.00899	0.001260	6.52e-03	0.01150
2.4	0.962	251.00	0.00899	0.001320	6.39e-03	0.01160
2.5	0.953	316.00	0.00899	0.001380	6.28e-03	0.01170
2.6	0.947	398.00	0.00899	0.001390	6.26e-03	0.01170
2.7	0.931	501.00	0.00899	0.001460	6.13e-03	0.01180
2.8	0.925	631.00	0.00899	0.001450	6.13e-03	0.01180
2.9	0.917	794.00	0.00899	0.001520	6.00e-03	0.01200
3.0	0.907	1000.00	0.00899	0.001660	5.74e-03	0.01220
3.1	0.895	1260.00	0.00899	0.001910	5.24e-03	0.01270
3.2	0.876	1580.00	0.00899	0.001940	5.19e-03	0.01280
3.3	0.862	2000.00	0.00899	0.002430	4.23e-03	0.01370
3.4	0.853	2510.00	0.00784	0.002290	3.34e-03	0.01230
3.5	0.838	3160.00	0.00728	0.002230	2.91e-03	0.01160
3.6	0.814	3980.00	0.00728	0.003010	1.38e-03	0.01320
3.7	0.788	5010.00	0.00620	0.003010	2.93e-04	0.01210
3.8	0.746	6310.00	0.00230	0.000708	9.13e-04	0.00369
3.9	0.700	7940.00	0.00230	0.000708	9.13e-04	0.00369
4.0	0.638	10000.00	0.00230	0.000790	7.51e-04	0.00385
4.1	0.541	12600.00	0.00230	0.000991	3.58e-04	0.00424
4.2	0.498	15800.00	0.00230	0.000963	4.13e-04	0.00419
4.3	0.413	20000.00	0.00230	0.000863	6.08e-04	0.00399
4.4	0.205	25100.00	0.00230	0.001220	-9.17e-05	0.00469

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00870	0.001040	0.006720	0.01150
0.1	1.26	0.995	0.00904	0.001210	0.006660	0.01140
0.2	1.58	0.995	0.00904	0.001210	0.006660	0.01140
0.3	2.00	0.995	0.00904	0.001210	0.006660	0.01140
0.4	2.51	0.995	0.00904	0.001210	0.006660	0.01140
0.5	3.16	0.995	0.00904	0.001210	0.006660	0.01140
0.6	3.98	0.995	0.00904	0.001210	0.006660	0.01140
0.7	5.01	0.994	0.00892	0.001200	0.006560	0.01130
0.8	6.31	0.992	0.00892	0.001200	0.006560	0.01130
0.9	7.94	0.992	0.00879	0.001190	0.006450	0.01110
1.0	10.00	0.992	0.00879	0.001190	0.006450	0.01110
1.1	12.60	0.992	0.00869	0.001190	0.006360	0.01100
1.2	15.80	0.991	0.00871	0.001190	0.006380	0.01100
1.3	20.00	0.991	0.00871	0.001190	0.006380	0.01100
1.4	25.10	0.990	0.00875	0.001190	0.006400	0.01110
1.5	31.60	0.989	0.00879	0.001200	0.006430	0.01110
1.6	39.80	0.989	0.00881	0.001200	0.006450	0.01120
1.7	50.10	0.989	0.00883	0.001210	0.006460	0.01120
1.8	63.10	0.986	0.00890	0.001220	0.006510	0.01130
1.9	79.40	0.985	0.00894	0.001220	0.006540	0.01130
2.0	100.00	0.985	0.00883	0.001210	0.006450	0.01120
2.1	126.00	0.979	0.00889	0.001230	0.006480	0.01130
2.2	158.00	0.972	0.00891	0.001250	0.006450	0.01140
2.3	200.00	0.970	0.00887	0.001260	0.006400	0.01130
2.4	251.00	0.962	0.00928	0.001320	0.006690	0.01190
2.5	316.00	0.953	0.00956	0.001380	0.006860	0.01230
2.6	398.00	0.947	0.00938	0.001390	0.006650	0.01210
2.7	501.00	0.931	0.00941	0.001460	0.006560	0.01230
2.8	631.00	0.925	0.00893	0.001450	0.006080	0.01180
2.9	794.00	0.917	0.00895	0.001520	0.005960	0.01190
3.0	1000.00	0.907	0.00931	0.001660	0.006060	0.01260
3.1	1260.00	0.895	0.01000	0.001910	0.006250	0.01370
3.2	1580.00	0.876	0.00868	0.001940	0.004880	0.01250
3.3	2000.00	0.862	0.00954	0.002430	0.004780	0.01430
3.4	2510.00	0.853	0.00784	0.002290	0.003340	0.01230
3.5	3160.00	0.838	0.00689	0.002230	0.002520	0.01130
3.6	3980.00	0.814	0.00768	0.003010	0.001780	0.01360
3.7	5010.00	0.788	0.00620	0.003010	0.000293	0.01210
3.8	6310.00	0.746	0.00226	0.000708	0.000876	0.00365
3.9	7940.00	0.700	0.00222	0.000708	0.000827	0.00360
4.0	10000.00	0.638	0.00228	0.000790	0.000726	0.00382
4.1	12600.00	0.541	0.00245	0.000991	0.000510	0.00439
4.2	15800.00	0.498	0.00231	0.000963	0.000425	0.00420
4.3	20000.00	0.413	0.00561	0.000863	0.003920	0.00730
4.4	25100.00	0.205	0.00643	0.001220	0.004040	0.00883

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.265	0.1150	0.040700	0.490
0.1	0.995	1.26	0.265	0.1260	0.019300	0.512
0.2	0.995	1.58	0.265	0.1260	0.019300	0.512
0.3	0.995	2.00	0.265	0.1260	0.019300	0.512
0.4	0.995	2.51	0.265	0.1260	0.019300	0.512
0.5	0.995	3.16	0.265	0.1260	0.019300	0.512
0.6	0.995	3.98	0.265	0.1260	0.019300	0.512
0.7	0.994	5.01	0.266	0.1250	0.021100	0.511
0.8	0.992	6.31	0.266	0.1250	0.021000	0.511
0.9	0.992	7.94	0.266	0.1240	0.022300	0.510
1.0	0.992	10.00	0.266	0.1240	0.022300	0.510
1.1	0.992	12.60	0.266	0.1240	0.023300	0.509
1.2	0.991	15.80	0.266	0.1240	0.022900	0.509
1.3	0.991	20.00	0.266	0.1240	0.022900	0.509
1.4	0.990	25.10	0.266	0.1240	0.022400	0.510
1.5	0.989	31.60	0.266	0.1250	0.021600	0.510
1.6	0.989	39.80	0.266	0.1250	0.021300	0.511
1.7	0.989	50.10	0.266	0.1250	0.020900	0.511
1.8	0.986	63.10	0.266	0.1260	0.019600	0.512
1.9	0.985	79.40	0.266	0.1260	0.018900	0.513
2.0	0.985	100.00	0.266	0.1260	0.019800	0.512
2.1	0.979	126.00	0.266	0.1270	0.017500	0.514
2.2	0.972	158.00	0.266	0.1280	0.014700	0.517
2.3	0.970	200.00	0.266	0.1290	0.014000	0.518
2.4	0.962	251.00	0.266	0.1330	0.005710	0.526
2.5	0.953	316.00	0.266	0.1370	-0.001940	0.534
2.6	0.947	398.00	0.266	0.1370	-0.003170	0.535
2.7	0.931	501.00	0.266	0.1420	-0.012000	0.544
2.8	0.925	631.00	0.266	0.1420	-0.011600	0.544
2.9	0.917	794.00	0.266	0.1460	-0.021000	0.553
3.0	0.907	1000.00	0.266	0.1560	-0.039100	0.571
3.1	0.895	1260.00	0.266	0.1740	-0.075500	0.607
3.2	0.876	1580.00	0.266	0.1760	-0.079100	0.611
3.3	0.862	2000.00	0.266	0.2130	-0.151000	0.683
3.4	0.853	2510.00	0.360	0.1990	-0.030500	0.750
3.5	0.838	3160.00	0.406	0.1920	0.028800	0.783
3.6	0.814	3980.00	0.406	0.2530	-0.091000	0.902
3.7	0.788	5010.00	0.494	0.2520	0.000786	0.987
3.8	0.746	6310.00	0.812	0.0611	0.692000	0.932
3.9	0.700	7940.00	0.812	0.0611	0.692000	0.932
4.0	0.638	10000.00	0.812	0.0675	0.680000	0.944
4.1	0.541	12600.00	0.812	0.0833	0.649000	0.975
4.2	0.498	15800.00	0.812	0.0811	0.653000	0.971
4.3	0.413	20000.00	0.812	0.0732	0.669000	0.956
4.4	0.205	25100.00	0.812	0.1020	0.613000	1.010

IgG V1V2 C.1086-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00895	0.00104	0.00692	0.01100
0.1	0.9940	1.26	0.00895	0.00120	0.00661	0.01130
0.2	0.9930	1.58	0.00895	0.00120	0.00661	0.01130
0.3	0.9930	2.00	0.00895	0.00120	0.00661	0.01130
0.4	0.9920	2.51	0.00895	0.00120	0.00661	0.01130
0.5	0.9920	3.16	0.00895	0.00120	0.00661	0.01130
0.6	0.9920	3.98	0.00895	0.00120	0.00661	0.01130
0.7	0.9920	5.01	0.00895	0.00120	0.00661	0.01130
0.8	0.9920	6.31	0.00895	0.00120	0.00661	0.01130
0.9	0.9920	7.94	0.00895	0.00120	0.00661	0.01130
1.0	0.9920	10.00	0.00895	0.00119	0.00663	0.01130
1.1	0.9920	12.60	0.00895	0.00118	0.00665	0.01130
1.2	0.9910	15.80	0.00895	0.00118	0.00663	0.01130
1.3	0.9890	20.00	0.00895	0.00119	0.00662	0.01130
1.4	0.9890	25.10	0.00895	0.00118	0.00664	0.01130
1.5	0.9850	31.60	0.00895	0.00120	0.00661	0.01130
1.6	0.9800	39.80	0.00895	0.00122	0.00657	0.01130
1.7	0.9790	50.10	0.00895	0.00121	0.00657	0.01130
1.8	0.9760	63.10	0.00895	0.00122	0.00656	0.01130
1.9	0.9680	79.40	0.00895	0.00124	0.00652	0.01140
2.0	0.9650	100.00	0.00895	0.00125	0.00650	0.01140
2.1	0.9590	126.00	0.00895	0.00131	0.00639	0.01150
2.2	0.9490	158.00	0.00895	0.00135	0.00632	0.01160
2.3	0.9440	200.00	0.00895	0.00136	0.00628	0.01160
2.4	0.9370	251.00	0.00895	0.00145	0.00611	0.01180
2.5	0.9120	316.00	0.00895	0.00155	0.00591	0.01200
2.6	0.8970	398.00	0.00895	0.00154	0.00593	0.01200
2.7	0.8820	501.00	0.00895	0.00183	0.00537	0.01250
2.8	0.8660	631.00	0.00895	0.00194	0.00516	0.01270
2.9	0.8560	794.00	0.00895	0.00196	0.00512	0.01280
3.0	0.8420	1000.00	0.00895	0.00202	0.00500	0.01290
3.1	0.8080	1260.00	0.00895	0.00259	0.00387	0.01400
3.2	0.7570	1580.00	0.00719	0.00226	0.00276	0.01160
3.3	0.7060	2000.00	0.00542	0.00178	0.00194	0.00890
3.4	0.6550	2510.00	0.00542	0.00206	0.00138	0.00946
3.5	0.5590	3160.00	0.00542	0.00340	-0.00124	0.01210
3.6	0.4860	3980.00	0.00542	0.00430	-0.00301	0.01380
3.7	0.4110	5010.00	0.00542	0.00443	-0.00327	0.01410
3.8	0.3430	6310.00	0.00542	0.00463	-0.00365	0.01450
3.9	0.2490	7940.00	0.00542	0.00522	-0.00482	0.01570
4.0	0.1750	10000.00	0.00542	0.00608	-0.00650	0.01730
4.1	0.1390	12600.00	0.00542	0.00764	-0.00956	0.02040
4.2	0.0994	15800.00	0.00542	0.00795	-0.01020	0.02100

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00870	0.00104	0.006720	0.01150
0.1	1.26	0.9940	0.00881	0.00120	0.006460	0.01120
0.2	1.58	0.9930	0.00881	0.00120	0.006470	0.01120
0.3	2.00	0.9930	0.00881	0.00120	0.006470	0.01120
0.4	2.51	0.9920	0.00882	0.00120	0.006470	0.01120
0.5	3.16	0.9920	0.00882	0.00120	0.006470	0.01120
0.6	3.98	0.9920	0.00882	0.00120	0.006470	0.01120
0.7	5.01	0.9920	0.00882	0.00120	0.006470	0.01120
0.8	6.31	0.9920	0.00882	0.00120	0.006470	0.01120
0.9	7.94	0.9920	0.00882	0.00120	0.006470	0.01120
1.0	10.00	0.9920	0.00869	0.00119	0.006360	0.01100
1.1	12.60	0.9920	0.00856	0.00118	0.006250	0.01090
1.2	15.80	0.9910	0.00860	0.00118	0.006280	0.01090
1.3	20.00	0.9890	0.00865	0.00119	0.006320	0.01100
1.4	25.10	0.9890	0.00852	0.00118	0.006210	0.01080
1.5	31.60	0.9850	0.00864	0.00120	0.006290	0.01100
1.6	39.80	0.9800	0.00879	0.00122	0.006400	0.01120
1.7	50.10	0.9790	0.00870	0.00121	0.006320	0.01110
1.8	63.10	0.9760	0.00868	0.00122	0.006290	0.01110
1.9	79.40	0.9680	0.00881	0.00124	0.006380	0.01120
2.0	100.00	0.9650	0.00883	0.00125	0.006370	0.01130
2.1	126.00	0.9590	0.00916	0.00131	0.006610	0.01170
2.2	158.00	0.9490	0.00921	0.00135	0.006570	0.01180
2.3	200.00	0.9440	0.00914	0.00136	0.006470	0.01180
2.4	251.00	0.9370	0.00967	0.00145	0.006820	0.01250
2.5	316.00	0.9120	0.00981	0.00155	0.006770	0.01290
2.6	398.00	0.8970	0.00922	0.00154	0.006190	0.01220
2.7	501.00	0.8820	0.01030	0.00183	0.006720	0.01390
2.8	631.00	0.8660	0.00959	0.00194	0.005800	0.01340
2.9	794.00	0.8560	0.00865	0.00196	0.004820	0.01250
3.0	1000.00	0.8420	0.00854	0.00202	0.004590	0.01250
3.1	1260.00	0.8080	0.01060	0.00259	0.005540	0.01570
3.2	1580.00	0.7570	0.00719	0.00226	0.002760	0.01160
3.3	2000.00	0.7060	0.00458	0.00178	0.001110	0.00806
3.4	2510.00	0.6550	0.00481	0.00206	0.000773	0.00885
3.5	3160.00	0.5590	0.00648	0.00340	-0.000180	0.01310
3.6	3980.00	0.4860	0.00602	0.00430	-0.002400	0.01440
3.7	5010.00	0.4110	0.00718	0.00443	-0.001500	0.01590
3.8	6310.00	0.3430	0.00799	0.00463	-0.001070	0.01710
3.9	7940.00	0.2490	0.00845	0.00522	-0.001780	0.01870
4.0	10000.00	0.1750	0.00924	0.00608	-0.002680	0.02120
4.1	12600.00	0.1390	0.01230	0.00764	-0.002680	0.02730
4.2	15800.00	0.0994	0.01200	0.00795	-0.003580	0.02760

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.269	0.114	0.04450	0.493
0.1	0.9940	1.26	0.269	0.124	0.02510	0.512
0.2	0.9930	1.58	0.269	0.124	0.02500	0.512
0.3	0.9930	2.00	0.269	0.124	0.02500	0.512
0.4	0.9920	2.51	0.269	0.124	0.02500	0.512
0.5	0.9920	3.16	0.269	0.124	0.02500	0.512
0.6	0.9920	3.98	0.269	0.124	0.02500	0.512
0.7	0.9920	5.01	0.269	0.124	0.02500	0.512
0.8	0.9920	6.31	0.269	0.124	0.02500	0.512
0.9	0.9920	7.94	0.269	0.124	0.02500	0.512
1.0	0.9920	10.00	0.269	0.124	0.02630	0.511
1.1	0.9920	12.60	0.269	0.123	0.02760	0.510
1.2	0.9910	15.80	0.269	0.123	0.02680	0.511
1.3	0.9890	20.00	0.269	0.124	0.02610	0.511
1.4	0.9890	25.10	0.269	0.123	0.02740	0.510
1.5	0.9850	31.60	0.269	0.124	0.02520	0.512
1.6	0.9800	39.80	0.269	0.126	0.02240	0.515
1.7	0.9790	50.10	0.269	0.125	0.02300	0.514
1.8	0.9760	63.10	0.269	0.126	0.02210	0.515
1.9	0.9680	79.40	0.269	0.127	0.01960	0.518
2.0	0.9650	100.00	0.269	0.128	0.01790	0.519
2.1	0.9590	126.00	0.269	0.131	0.01120	0.526
2.2	0.9490	158.00	0.269	0.134	0.00591	0.532
2.3	0.9440	200.00	0.269	0.135	0.00379	0.534
2.4	0.9370	251.00	0.269	0.141	-0.00808	0.546
2.5	0.9120	316.00	0.269	0.148	-0.02180	0.559
2.6	0.8970	398.00	0.269	0.148	-0.02070	0.558
2.7	0.8820	501.00	0.269	0.168	-0.06020	0.598
2.8	0.8660	631.00	0.269	0.176	-0.07600	0.613
2.9	0.8560	794.00	0.269	0.177	-0.07880	0.616
3.0	0.8420	1000.00	0.269	0.182	-0.08780	0.625
3.1	0.8080	1260.00	0.269	0.225	-0.17300	0.710
3.2	0.7570	1580.00	0.412	0.195	0.03040	0.794
3.3	0.7060	2000.00	0.558	0.152	0.25900	0.856
3.4	0.6550	2510.00	0.558	0.175	0.21500	0.900
3.5	0.5590	3160.00	0.558	0.281	0.00614	1.110
3.6	0.4860	3980.00	0.558	0.354	-0.13600	1.250
3.7	0.4110	5010.00	0.558	0.365	-0.15800	1.270
3.8	0.3430	6310.00	0.558	0.381	-0.18900	1.300
3.9	0.2490	7940.00	0.558	0.429	-0.28300	1.400
4.0	0.1750	10000.00	0.558	0.499	-0.42100	1.540
4.1	0.1390	12600.00	0.558	0.626	-0.66900	1.780
4.2	0.0994	15800.00	0.558	0.651	-0.71800	1.830

IgG V1V2 C.1086-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00909	0.00104	0.00705	0.0111
0.1	0.993	1.26	0.00909	0.00123	0.00668	0.0115
0.2	0.993	1.58	0.00909	0.00123	0.00668	0.0115
0.3	0.993	2.00	0.00909	0.00123	0.00668	0.0115
0.4	0.991	2.51	0.00909	0.00123	0.00668	0.0115
0.5	0.990	3.16	0.00909	0.00123	0.00668	0.0115
0.6	0.990	3.98	0.00909	0.00123	0.00668	0.0115
0.7	0.990	5.01	0.00903	0.00122	0.00664	0.0114
0.8	0.990	6.31	0.00903	0.00122	0.00664	0.0114
0.9	0.990	7.94	0.00903	0.00122	0.00664	0.0114
1.0	0.990	10.00	0.00903	0.00122	0.00664	0.0114
1.1	0.988	12.60	0.00900	0.00121	0.00663	0.0114
1.2	0.988	15.80	0.00900	0.00121	0.00663	0.0114
1.3	0.988	20.00	0.00900	0.00121	0.00663	0.0114
1.4	0.988	25.10	0.00900	0.00121	0.00662	0.0114
1.5	0.988	31.60	0.00900	0.00121	0.00662	0.0114
1.6	0.988	39.80	0.00900	0.00121	0.00662	0.0114
1.7	0.987	50.10	0.00900	0.00120	0.00664	0.0114
1.8	0.987	63.10	0.00900	0.00121	0.00663	0.0114
1.9	0.985	79.40	0.00900	0.00121	0.00663	0.0114
2.0	0.984	100.00	0.00900	0.00121	0.00662	0.0114
2.1	0.982	126.00	0.00900	0.00122	0.00661	0.0114
2.2	0.981	158.00	0.00900	0.00122	0.00661	0.0114
2.3	0.980	200.00	0.00900	0.00123	0.00659	0.0114
2.4	0.980	251.00	0.00900	0.00123	0.00659	0.0114
2.5	0.973	316.00	0.00900	0.00124	0.00657	0.0114
2.6	0.971	398.00	0.00900	0.00125	0.00654	0.0115
2.7	0.969	501.00	0.00900	0.00125	0.00655	0.0114
2.8	0.961	631.00	0.00900	0.00130	0.00646	0.0115
2.9	0.941	794.00	0.00900	0.00131	0.00642	0.0116
3.0	0.937	1000.00	0.00900	0.00134	0.00638	0.0116
3.1	0.929	1260.00	0.00900	0.00136	0.00633	0.0117
3.2	0.916	1580.00	0.00900	0.00136	0.00634	0.0117
3.3	0.894	2000.00	0.00900	0.00139	0.00627	0.0117
3.4	0.870	2510.00	0.00900	0.00141	0.00624	0.0118
3.5	0.846	3160.00	0.00900	0.00149	0.00607	0.0119
3.6	0.806	3980.00	0.00900	0.00163	0.00581	0.0122
3.7	0.723	5010.00	0.00900	0.00170	0.00567	0.0123
3.8	0.645	6310.00	0.00900	0.00171	0.00565	0.0123
3.9	0.557	7940.00	0.00900	0.00186	0.00536	0.0126
4.0	0.470	10000.00	0.00900	0.00222	0.00466	0.0133
4.1	0.386	12600.00	0.00857	0.00212	0.00441	0.0127
4.2	0.308	15800.00	0.00857	0.00235	0.00396	0.0132
4.3	0.228	20000.00	0.00857	0.00277	0.00314	0.0140

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00870	0.00104	0.00672	0.0115
0.1	1.26	0.993	0.00915	0.00123	0.00674	0.0116
0.2	1.58	0.993	0.00915	0.00123	0.00674	0.0116
0.3	2.00	0.993	0.00915	0.00123	0.00674	0.0116
0.4	2.51	0.991	0.00915	0.00123	0.00675	0.0116
0.5	3.16	0.990	0.00916	0.00123	0.00675	0.0116
0.6	3.98	0.990	0.00916	0.00123	0.00675	0.0116
0.7	5.01	0.990	0.00903	0.00122	0.00664	0.0114
0.8	6.31	0.990	0.00903	0.00122	0.00664	0.0114
0.9	7.94	0.990	0.00903	0.00122	0.00664	0.0114
1.0	10.00	0.990	0.00903	0.00122	0.00664	0.0114
1.1	12.60	0.988	0.00890	0.00121	0.00653	0.0113
1.2	15.80	0.988	0.00890	0.00121	0.00653	0.0113
1.3	20.00	0.988	0.00890	0.00121	0.00653	0.0113
1.4	25.10	0.988	0.00892	0.00121	0.00655	0.0113
1.5	31.60	0.988	0.00892	0.00121	0.00655	0.0113
1.6	39.80	0.988	0.00892	0.00121	0.00655	0.0113
1.7	50.10	0.987	0.00881	0.00120	0.00645	0.0112
1.8	63.10	0.987	0.00883	0.00121	0.00647	0.0112
1.9	79.40	0.985	0.00884	0.00121	0.00647	0.0112
2.0	100.00	0.984	0.00886	0.00121	0.00649	0.0112
2.1	126.00	0.982	0.00891	0.00122	0.00652	0.0113
2.2	158.00	0.981	0.00893	0.00122	0.00654	0.0113
2.3	200.00	0.980	0.00897	0.00123	0.00657	0.0114
2.4	251.00	0.980	0.00899	0.00123	0.00658	0.0114
2.5	316.00	0.973	0.00900	0.00124	0.00657	0.0114
2.6	398.00	0.971	0.00909	0.00125	0.00663	0.0115
2.7	501.00	0.969	0.00894	0.00125	0.00649	0.0114
2.8	631.00	0.961	0.00924	0.00130	0.00670	0.0118
2.9	794.00	0.941	0.00923	0.00131	0.00665	0.0118
3.0	1000.00	0.937	0.00929	0.00134	0.00668	0.0119
3.1	1260.00	0.929	0.00938	0.00136	0.00671	0.0120
3.2	1580.00	0.916	0.00899	0.00136	0.00633	0.0116
3.3	2000.00	0.894	0.00884	0.00139	0.00612	0.0116
3.4	2510.00	0.870	0.00865	0.00141	0.00589	0.0114
3.5	3160.00	0.846	0.00903	0.00149	0.00610	0.0120
3.6	3980.00	0.806	0.00946	0.00163	0.00627	0.0126
3.7	5010.00	0.723	0.00911	0.00170	0.00577	0.0124
3.8	6310.00	0.645	0.00852	0.00171	0.00518	0.0119
3.9	7940.00	0.557	0.00876	0.00186	0.00512	0.0124
4.0	10000.00	0.470	0.01020	0.00222	0.00583	0.0145
4.1	12600.00	0.386	0.00813	0.00212	0.00397	0.0123
4.2	15800.00	0.308	0.00826	0.00235	0.00365	0.0129
4.3	20000.00	0.228	0.00946	0.00277	0.00404	0.0149

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.258	0.115	0.032000	0.484
0.1	0.993	1.26	0.258	0.127	0.008860	0.507
0.2	0.993	1.58	0.258	0.127	0.008860	0.507
0.3	0.993	2.00	0.258	0.127	0.008860	0.507
0.4	0.991	2.51	0.258	0.127	0.008780	0.507
0.5	0.990	3.16	0.258	0.127	0.008710	0.507
0.6	0.990	3.98	0.258	0.127	0.008710	0.507
0.7	0.990	5.01	0.262	0.126	0.015200	0.510
0.8	0.990	6.31	0.262	0.126	0.015200	0.510
0.9	0.990	7.94	0.262	0.126	0.015200	0.510
1.0	0.990	10.00	0.262	0.126	0.015200	0.510
1.1	0.988	12.60	0.265	0.125	0.019400	0.511
1.2	0.988	15.80	0.265	0.125	0.019400	0.511
1.3	0.988	20.00	0.265	0.125	0.019400	0.511
1.4	0.988	25.10	0.265	0.125	0.019100	0.511
1.5	0.988	31.60	0.265	0.125	0.019100	0.511
1.6	0.988	39.80	0.265	0.125	0.019100	0.511
1.7	0.987	50.10	0.265	0.125	0.019900	0.510
1.8	0.987	63.10	0.265	0.125	0.019600	0.510
1.9	0.985	79.40	0.265	0.125	0.019500	0.510
2.0	0.984	100.00	0.265	0.125	0.019100	0.511
2.1	0.982	126.00	0.265	0.126	0.018200	0.512
2.2	0.981	158.00	0.265	0.126	0.017800	0.512
2.3	0.980	200.00	0.265	0.126	0.017100	0.513
2.4	0.980	251.00	0.265	0.127	0.016700	0.513
2.5	0.973	316.00	0.265	0.127	0.015400	0.515
2.6	0.971	398.00	0.265	0.128	0.013700	0.516
2.7	0.969	501.00	0.265	0.128	0.014200	0.516
2.8	0.961	631.00	0.265	0.131	0.008010	0.522
2.9	0.941	794.00	0.265	0.132	0.005880	0.524
3.0	0.937	1000.00	0.265	0.134	0.002980	0.527
3.1	0.929	1260.00	0.265	0.135	-0.000187	0.530
3.2	0.916	1580.00	0.265	0.135	0.000372	0.530
3.3	0.894	2000.00	0.265	0.137	-0.004330	0.534
3.4	0.870	2510.00	0.265	0.138	-0.006200	0.536
3.5	0.846	3160.00	0.265	0.144	-0.018000	0.548
3.6	0.806	3980.00	0.265	0.154	-0.036000	0.566
3.7	0.723	5010.00	0.265	0.159	-0.046400	0.576
3.8	0.645	6310.00	0.265	0.159	-0.047600	0.578
3.9	0.557	7940.00	0.265	0.170	-0.068500	0.598
4.0	0.470	10000.00	0.265	0.197	-0.121000	0.651
4.1	0.386	12600.00	0.300	0.188	-0.068800	0.669
4.2	0.308	15800.00	0.300	0.206	-0.103000	0.703
4.3	0.228	20000.00	0.300	0.238	-0.165000	0.766

IgG3 V1V2 B.CaseA-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00870	0.00104	0.006660	0.01070
0.1	0.9160	1.26	0.00851	0.00144	0.005680	0.01130
0.2	0.9110	1.58	0.00838	0.00144	0.005560	0.01120
0.3	0.9090	2.00	0.00838	0.00148	0.005490	0.01130
0.4	0.8870	2.51	0.00834	0.00147	0.005450	0.01120
0.5	0.8860	3.16	0.00826	0.00145	0.005420	0.01110
0.6	0.8690	3.98	0.00826	0.00151	0.005290	0.01120
0.7	0.8580	5.01	0.00799	0.00150	0.005040	0.01090
0.8	0.8570	6.31	0.00783	0.00150	0.004890	0.01080
0.9	0.8480	7.94	0.00782	0.00153	0.004820	0.01080
1.0	0.8200	10.00	0.00766	0.00148	0.004760	0.01050
1.1	0.7670	12.60	0.00766	0.00152	0.004670	0.01060
1.2	0.7380	15.80	0.00750	0.00150	0.004550	0.01040
1.3	0.7020	20.00	0.00735	0.00150	0.004400	0.01030
1.4	0.6650	25.10	0.00735	0.00160	0.004220	0.01050
1.5	0.6210	31.60	0.00713	0.00158	0.004040	0.01020
1.6	0.5750	39.80	0.00650	0.00152	0.003520	0.00949
1.7	0.4890	50.10	0.00650	0.00162	0.003320	0.00968
1.8	0.4480	63.10	0.00643	0.00167	0.003140	0.00971
1.9	0.3790	79.40	0.00607	0.00175	0.002640	0.00951
2.0	0.3170	100.00	0.00559	0.00177	0.002130	0.00905
2.1	0.2760	126.00	0.00559	0.00187	0.001940	0.00925
2.2	0.2270	158.00	0.00558	0.00205	0.001560	0.00959
2.3	0.2010	200.00	0.00558	0.00232	0.001030	0.01010
2.4	0.1610	251.00	0.00558	0.00236	0.000952	0.01020
2.5	0.1300	316.00	0.00558	0.00234	0.000992	0.01020
2.6	0.1020	398.00	0.00558	0.00247	0.000735	0.01040
2.7	0.0838	501.00	0.00558	0.00294	-0.000189	0.01130
2.8	0.0584	631.00	0.00558	0.00543	-0.005070	0.01620
2.9	0.0536	794.00	0.00558	0.00542	-0.005040	0.01620
3.0	0.0428	1000.00	0.00558	0.01250	-0.019000	0.03020
3.1	0.0327	1260.00	0.00558	0.01820	-0.030000	0.04120
3.2	0.0307	1580.00	0.00558	0.02400	-0.041500	0.05260
3.3	0.0304	2000.00	0.00558	0.02900	-0.051300	0.06250

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00870	0.00104	0.006720	0.01150
0.1	1.26	0.9160	0.00851	0.00144	0.005680	0.01130
0.2	1.58	0.9110	0.00830	0.00144	0.005480	0.01110
0.3	2.00	0.9090	0.00847	0.00148	0.005570	0.01140
0.4	2.51	0.8870	0.00834	0.00147	0.005450	0.01120
0.5	3.16	0.8860	0.00811	0.00145	0.005260	0.01090
0.6	3.98	0.8690	0.00842	0.00151	0.005450	0.01140
0.7	5.01	0.8580	0.00799	0.00150	0.005040	0.01090
0.8	6.31	0.8570	0.00783	0.00150	0.004890	0.01080
0.9	7.94	0.8480	0.00782	0.00153	0.004830	0.01080
1.0	10.00	0.8200	0.00764	0.00148	0.004750	0.01050
1.1	12.60	0.7670	0.00767	0.00152	0.004690	0.01070
1.2	15.80	0.7380	0.00750	0.00150	0.004550	0.01040
1.3	20.00	0.7020	0.00715	0.00150	0.004210	0.01010
1.4	25.10	0.6650	0.00755	0.00160	0.004420	0.01070
1.5	31.60	0.6210	0.00713	0.00158	0.004040	0.01020
1.6	39.80	0.5750	0.00637	0.00152	0.003390	0.00936
1.7	50.10	0.4890	0.00664	0.00162	0.003460	0.00982
1.8	63.10	0.4480	0.00643	0.00167	0.003140	0.00971
1.9	79.40	0.3790	0.00607	0.00175	0.002640	0.00951
2.0	100.00	0.3170	0.00557	0.00177	0.002110	0.00903
2.1	126.00	0.2760	0.00561	0.00187	0.001960	0.00927
2.2	158.00	0.2270	0.00551	0.00205	0.001490	0.00953
2.3	200.00	0.2010	0.00579	0.00232	0.001240	0.01030
2.4	251.00	0.1610	0.00552	0.00236	0.000900	0.01010
2.5	316.00	0.1300	0.00481	0.00234	0.000227	0.00940
2.6	398.00	0.1020	0.00454	0.00247	-0.000305	0.00938
2.7	501.00	0.0838	0.00529	0.00294	-0.000472	0.01110
2.8	631.00	0.0584	0.00809	0.00543	-0.002550	0.01870
2.9	794.00	0.0536	0.00744	0.00542	-0.003190	0.01810
3.0	1000.00	0.0428	0.01450	0.01250	-0.010100	0.03910
3.1	1260.00	0.0327	0.02130	0.01820	-0.014300	0.05690
3.2	1580.00	0.0307	0.02540	0.02400	-0.021600	0.07250
3.3	2000.00	0.0304	0.02970	0.02900	-0.027200	0.08660

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.290	0.113	0.0684	0.511
0.1	0.9160	1.26	0.305	0.139	0.0330	0.577
0.2	0.9110	1.58	0.315	0.138	0.0455	0.585
0.3	0.9090	2.00	0.315	0.140	0.0402	0.591
0.4	0.8870	2.51	0.319	0.140	0.0442	0.593
0.5	0.8860	3.16	0.325	0.138	0.0548	0.596
0.6	0.8690	3.98	0.325	0.143	0.0458	0.605
0.7	0.8580	5.01	0.347	0.141	0.0716	0.623
0.8	0.8570	6.31	0.360	0.140	0.0862	0.634
0.9	0.8480	7.94	0.361	0.142	0.0831	0.639
1.0	0.8200	10.00	0.375	0.137	0.1060	0.644
1.1	0.7670	12.60	0.375	0.141	0.0990	0.650
1.2	0.7380	15.80	0.388	0.139	0.1160	0.659
1.3	0.7020	20.00	0.400	0.138	0.1300	0.670
1.4	0.6650	25.10	0.400	0.145	0.1160	0.684
1.5	0.6210	31.60	0.418	0.143	0.1380	0.697
1.6	0.5750	39.80	0.469	0.136	0.2010	0.736
1.7	0.4890	50.10	0.469	0.144	0.1870	0.751
1.8	0.4480	63.10	0.475	0.147	0.1860	0.764
1.9	0.3790	79.40	0.504	0.152	0.2050	0.803
2.0	0.3170	100.00	0.543	0.152	0.2450	0.841
2.1	0.2760	126.00	0.543	0.160	0.2300	0.856
2.2	0.2270	158.00	0.545	0.174	0.2030	0.886
2.3	0.2010	200.00	0.545	0.196	0.1610	0.928
2.4	0.1610	251.00	0.545	0.199	0.1550	0.934
2.5	0.1300	316.00	0.545	0.197	0.1590	0.931
2.6	0.1020	398.00	0.545	0.207	0.1380	0.951
2.7	0.0838	501.00	0.545	0.245	0.0644	1.020
2.8	0.0584	631.00	0.545	0.446	-0.3300	1.420
2.9	0.0536	794.00	0.545	0.445	-0.3280	1.420
3.0	0.0428	1000.00	0.545	1.030	-1.4700	2.550
3.1	0.0327	1260.00	0.545	1.480	-2.3700	3.450
3.2	0.0307	1580.00	0.545	1.960	-3.3000	4.390
3.3	0.0304	2000.00	0.545	2.370	-4.1000	5.190

IgG3 V1V2 AE.A244-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00913	0.00104	7.09e-03	0.01120
0.1	0.9790	1.26	0.00913	0.00125	6.68e-03	0.01160
0.2	0.9780	1.58	0.00913	0.00126	6.66e-03	0.01160
0.3	0.9770	2.00	0.00913	0.00127	6.65e-03	0.01160
0.4	0.9760	2.51	0.00913	0.00127	6.63e-03	0.01160
0.5	0.9740	3.16	0.00913	0.00128	6.62e-03	0.01160
0.6	0.9710	3.98	0.00913	0.00128	6.63e-03	0.01160
0.7	0.9670	5.01	0.00913	0.00126	6.66e-03	0.01160
0.8	0.9640	6.31	0.00913	0.00128	6.62e-03	0.01160
0.9	0.9560	7.94	0.00913	0.00133	6.53e-03	0.01170
1.0	0.9500	10.00	0.00913	0.00134	6.49e-03	0.01180
1.1	0.9430	12.60	0.00913	0.00134	6.50e-03	0.01180
1.2	0.9390	15.80	0.00913	0.00135	6.48e-03	0.01180
1.3	0.9320	20.00	0.00913	0.00138	6.42e-03	0.01180
1.4	0.9220	25.10	0.00913	0.00145	6.28e-03	0.01200
1.5	0.9160	31.60	0.00913	0.00149	6.20e-03	0.01210
1.6	0.9110	39.80	0.00913	0.00150	6.19e-03	0.01210
1.7	0.9020	50.10	0.00904	0.00149	6.12e-03	0.01200
1.8	0.8880	63.10	0.00904	0.00159	5.93e-03	0.01210
1.9	0.8750	79.40	0.00894	0.00155	5.90e-03	0.01200
2.0	0.8630	100.00	0.00894	0.00159	5.83e-03	0.01210
2.1	0.8560	126.00	0.00894	0.00177	5.48e-03	0.01240
2.2	0.8390	158.00	0.00894	0.00201	5.01e-03	0.01290
2.3	0.8100	200.00	0.00894	0.00202	4.99e-03	0.01290
2.4	0.7710	251.00	0.00718	0.00177	3.72e-03	0.01060
2.5	0.7340	316.00	0.00690	0.00181	3.35e-03	0.01040
2.6	0.6760	398.00	0.00636	0.00169	3.04e-03	0.00967
2.7	0.6330	501.00	0.00542	0.00155	2.37e-03	0.00847
2.8	0.5810	631.00	0.00542	0.00169	2.10e-03	0.00873
2.9	0.5200	794.00	0.00542	0.00193	1.63e-03	0.00921
3.0	0.4340	1000.00	0.00542	0.00230	9.04e-04	0.00993
3.1	0.3580	1260.00	0.00542	0.00255	4.15e-04	0.01040
3.2	0.2990	1580.00	0.00542	0.00218	1.16e-03	0.00968
3.3	0.2440	2000.00	0.00542	0.00275	3.83e-05	0.01080
3.4	0.1820	2510.00	0.00542	0.00401	-2.45e-03	0.01330
3.5	0.1510	3160.00	0.00498	0.00200	1.07e-03	0.00889
3.6	0.1170	3980.00	0.00498	0.00238	3.12e-04	0.00965
3.7	0.0992	5010.00	0.00415	0.00247	-6.79e-04	0.00899

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00870	0.00104	0.006720	0.01150
0.1	1.26	0.9790	0.00913	0.00125	0.006680	0.01160
0.2	1.58	0.9780	0.00918	0.00126	0.006710	0.01160
0.3	2.00	0.9770	0.00923	0.00127	0.006750	0.01170
0.4	2.51	0.9760	0.00929	0.00127	0.006790	0.01180
0.5	3.16	0.9740	0.00925	0.00128	0.006740	0.01180
0.6	3.98	0.9710	0.00910	0.00128	0.006600	0.01160
0.7	5.01	0.9670	0.00888	0.00126	0.006410	0.01140
0.8	6.31	0.9640	0.00901	0.00128	0.006500	0.01150
0.9	7.94	0.9560	0.00931	0.00133	0.006710	0.01190
1.0	10.00	0.9500	0.00919	0.00134	0.006560	0.01180
1.1	12.60	0.9430	0.00892	0.00134	0.006300	0.01150
1.2	15.80	0.9390	0.00892	0.00135	0.006270	0.01160
1.3	20.00	0.9320	0.00907	0.00138	0.006360	0.01180
1.4	25.10	0.9220	0.00930	0.00145	0.006450	0.01220
1.5	31.60	0.9160	0.00953	0.00149	0.006600	0.01250
1.6	39.80	0.9110	0.00925	0.00150	0.006310	0.01220
1.7	50.10	0.9020	0.00890	0.00149	0.005980	0.01180
1.8	63.10	0.8880	0.00917	0.00159	0.006060	0.01230
1.9	79.40	0.8750	0.00851	0.00155	0.005470	0.01160
2.0	100.00	0.8630	0.00841	0.00159	0.005300	0.01150
2.1	126.00	0.8560	0.00905	0.00177	0.005580	0.01250
2.2	158.00	0.8390	0.00968	0.00201	0.005750	0.01360
2.3	200.00	0.8100	0.00913	0.00202	0.005170	0.01310
2.4	251.00	0.7710	0.00718	0.00177	0.003720	0.01060
2.5	316.00	0.7340	0.00690	0.00181	0.003350	0.01040
2.6	398.00	0.6760	0.00636	0.00169	0.003040	0.00967
2.7	501.00	0.6330	0.00534	0.00155	0.002290	0.00838
2.8	631.00	0.5810	0.00510	0.00169	0.001790	0.00842
2.9	794.00	0.5200	0.00557	0.00193	0.001780	0.00936
3.0	1000.00	0.4340	0.00570	0.00230	0.001190	0.01020
3.1	1260.00	0.3580	0.00543	0.00255	0.000430	0.01040
3.2	1580.00	0.2990	0.00505	0.00218	0.000782	0.00931
3.3	2000.00	0.2440	0.00646	0.00275	0.001080	0.01180
3.4	2510.00	0.1820	0.00930	0.00401	0.001440	0.01720
3.5	3160.00	0.1510	0.00480	0.00200	0.000885	0.00871
3.6	3980.00	0.1170	0.00517	0.00238	0.000497	0.00984
3.7	5010.00	0.0992	0.00415	0.00247	-0.000679	0.00899

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.254	0.115	0.028000	0.481
0.1	0.9790	1.26	0.254	0.129	0.001940	0.507
0.2	0.9780	1.58	0.254	0.129	0.001110	0.507
0.3	0.9770	2.00	0.254	0.130	0.000152	0.508
0.4	0.9760	2.51	0.254	0.130	-0.001060	0.510
0.5	0.9740	3.16	0.254	0.130	-0.001470	0.510
0.6	0.9710	3.98	0.254	0.130	-0.001160	0.510
0.7	0.9670	5.01	0.254	0.129	0.000543	0.508
0.8	0.9640	6.31	0.254	0.131	-0.001900	0.510
0.9	0.9560	7.94	0.254	0.134	-0.007850	0.516
1.0	0.9500	10.00	0.254	0.135	-0.010100	0.519
1.1	0.9430	12.60	0.254	0.135	-0.009360	0.518
1.2	0.9390	15.80	0.254	0.135	-0.011200	0.520
1.3	0.9320	20.00	0.254	0.137	-0.015200	0.524
1.4	0.9220	25.10	0.254	0.142	-0.024600	0.533
1.5	0.9160	31.60	0.254	0.145	-0.029900	0.539
1.6	0.9110	39.80	0.254	0.145	-0.030400	0.539
1.7	0.9020	50.10	0.262	0.144	-0.020700	0.545
1.8	0.8880	63.10	0.262	0.151	-0.034000	0.558
1.9	0.8750	79.40	0.269	0.148	-0.021200	0.560
2.0	0.8630	100.00	0.269	0.151	-0.025900	0.565
2.1	0.8560	126.00	0.269	0.163	-0.050800	0.590
2.2	0.8390	158.00	0.269	0.181	-0.085100	0.624
2.3	0.8100	200.00	0.269	0.182	-0.086800	0.626
2.4	0.7710	251.00	0.413	0.157	0.106000	0.721
2.5	0.7340	316.00	0.437	0.159	0.125000	0.749
2.6	0.6760	398.00	0.481	0.148	0.190000	0.772
2.7	0.6330	501.00	0.557	0.135	0.292000	0.822
2.8	0.5810	631.00	0.557	0.146	0.272000	0.843
2.9	0.5200	794.00	0.557	0.165	0.235000	0.880
3.0	0.4340	1000.00	0.557	0.194	0.178000	0.937
3.1	0.3580	1260.00	0.557	0.214	0.139000	0.976
3.2	0.2990	1580.00	0.557	0.184	0.197000	0.917
3.3	0.2440	2000.00	0.557	0.229	0.109000	1.010
3.4	0.1820	2510.00	0.557	0.331	-0.091600	1.210
3.5	0.1510	3160.00	0.593	0.169	0.263000	0.923
3.6	0.1170	3980.00	0.593	0.199	0.203000	0.984
3.7	0.0992	5010.00	0.661	0.205	0.260000	1.060

IgG3 V1V2 C.1086-Tags

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.00925	0.00104	0.007210	0.01130
0.1	0.971	1.26	0.00925	0.00129	0.006720	0.01180
0.2	0.970	1.58	0.00925	0.00128	0.006740	0.01180
0.3	0.970	2.00	0.00925	0.00128	0.006740	0.01180
0.4	0.968	2.51	0.00925	0.00129	0.006710	0.01180
0.5	0.963	3.16	0.00925	0.00130	0.006700	0.01180
0.6	0.962	3.98	0.00925	0.00130	0.006700	0.01180
0.7	0.956	5.01	0.00921	0.00130	0.006660	0.01180
0.8	0.947	6.31	0.00909	0.00129	0.006550	0.01160
0.9	0.935	7.94	0.00909	0.00133	0.006480	0.01170
1.0	0.927	10.00	0.00909	0.00137	0.006410	0.01180
1.1	0.916	12.60	0.00909	0.00140	0.006350	0.01180
1.2	0.903	15.80	0.00909	0.00141	0.006330	0.01180
1.3	0.897	20.00	0.00887	0.00142	0.006090	0.01160
1.4	0.887	25.10	0.00820	0.00138	0.005510	0.01090
1.5	0.873	31.60	0.00820	0.00141	0.005430	0.01100
1.6	0.856	39.80	0.00820	0.00147	0.005320	0.01110
1.7	0.840	50.10	0.00820	0.00151	0.005250	0.01120
1.8	0.804	63.10	0.00820	0.00162	0.005030	0.01140
1.9	0.772	79.40	0.00820	0.00168	0.004920	0.01150
2.0	0.704	100.00	0.00820	0.00178	0.004720	0.01170
2.1	0.652	126.00	0.00794	0.00174	0.004530	0.01140
2.2	0.601	158.00	0.00733	0.00182	0.003760	0.01090
2.3	0.560	200.00	0.00646	0.00171	0.003110	0.00981
2.4	0.500	251.00	0.00646	0.00184	0.002860	0.01010
2.5	0.424	316.00	0.00646	0.00196	0.002620	0.01030
2.6	0.341	398.00	0.00646	0.00242	0.001710	0.01120
2.7	0.297	501.00	0.00646	0.00268	0.001200	0.01170
2.8	0.228	631.00	0.00547	0.00213	0.001300	0.00963
2.9	0.175	794.00	0.00547	0.00247	0.000623	0.01030
3.0	0.159	1000.00	0.00547	0.00263	0.000311	0.01060
3.1	0.120	1260.00	0.00354	0.00214	-0.000658	0.00774

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.000	0.00870	0.00104	0.006720	0.01150
0.1	1.26	0.971	0.00946	0.00129	0.006930	0.01200
0.2	1.58	0.970	0.00926	0.00128	0.006750	0.01180
0.3	2.00	0.970	0.00926	0.00128	0.006750	0.01180
0.4	2.51	0.968	0.00935	0.00129	0.006810	0.01190
0.5	3.16	0.963	0.00941	0.00130	0.006860	0.01200
0.6	3.98	0.962	0.00933	0.00130	0.006780	0.01190
0.7	5.01	0.956	0.00921	0.00130	0.006660	0.01180
0.8	6.31	0.947	0.00889	0.00129	0.006350	0.01140
0.9	7.94	0.935	0.00905	0.00133	0.006440	0.01170
1.0	10.00	0.927	0.00919	0.00137	0.006510	0.01190
1.1	12.60	0.916	0.00923	0.00140	0.006490	0.01200
1.2	15.80	0.903	0.00910	0.00141	0.006340	0.01190
1.3	20.00	0.897	0.00887	0.00142	0.006090	0.01160
1.4	25.10	0.887	0.00808	0.00138	0.005380	0.01080
1.5	31.60	0.873	0.00806	0.00141	0.005290	0.01080
1.6	39.80	0.856	0.00822	0.00147	0.005330	0.01110
1.7	50.10	0.840	0.00813	0.00151	0.005180	0.01110
1.8	63.10	0.804	0.00826	0.00162	0.005090	0.01140
1.9	79.40	0.772	0.00810	0.00168	0.004820	0.01140
2.0	100.00	0.704	0.00863	0.00178	0.005150	0.01210
2.1	126.00	0.652	0.00794	0.00174	0.004530	0.01140
2.2	158.00	0.601	0.00733	0.00182	0.003760	0.01090
2.3	200.00	0.560	0.00641	0.00171	0.003060	0.00976
2.4	251.00	0.500	0.00628	0.00184	0.002670	0.00988
2.5	316.00	0.424	0.00593	0.00196	0.002080	0.00977
2.6	398.00	0.341	0.00673	0.00242	0.001980	0.01150
2.7	501.00	0.297	0.00714	0.00268	0.001880	0.01240
2.8	631.00	0.228	0.00475	0.00213	0.000578	0.00891
2.9	794.00	0.175	0.00545	0.00247	0.000606	0.01030
3.0	1000.00	0.159	0.00620	0.00263	0.001050	0.01140
3.1	1260.00	0.120	0.00354	0.00214	-0.000657	0.00774

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.000	1.00	0.245	0.116	0.017100	0.472
0.1	0.971	1.26	0.245	0.132	-0.013900	0.503
0.2	0.970	1.58	0.245	0.131	-0.012400	0.502
0.3	0.970	2.00	0.245	0.131	-0.012400	0.502
0.4	0.968	2.51	0.245	0.132	-0.014100	0.503
0.5	0.963	3.16	0.245	0.133	-0.015200	0.505
0.6	0.962	3.98	0.245	0.132	-0.014900	0.504
0.7	0.956	5.01	0.248	0.133	-0.012200	0.507
0.8	0.947	6.31	0.258	0.131	0.000177	0.515
0.9	0.935	7.94	0.258	0.134	-0.004600	0.520
1.0	0.927	10.00	0.258	0.136	-0.009130	0.524
1.1	0.916	12.60	0.258	0.138	-0.013400	0.529
1.2	0.903	15.80	0.258	0.139	-0.014400	0.530
1.3	0.897	20.00	0.276	0.138	0.004370	0.547
1.4	0.887	25.10	0.330	0.133	0.069900	0.590
1.5	0.873	31.60	0.330	0.135	0.064900	0.595
1.6	0.856	39.80	0.330	0.139	0.056600	0.603
1.7	0.840	50.10	0.330	0.142	0.052100	0.608
1.8	0.804	63.10	0.330	0.150	0.036400	0.623
1.9	0.772	79.40	0.330	0.154	0.028300	0.631
2.0	0.704	100.00	0.330	0.161	0.013700	0.646
2.1	0.652	126.00	0.352	0.158	0.042500	0.661
2.2	0.601	158.00	0.401	0.161	0.085200	0.718
2.3	0.560	200.00	0.472	0.150	0.178000	0.767
2.4	0.500	251.00	0.472	0.160	0.158000	0.786
2.5	0.424	316.00	0.472	0.170	0.140000	0.804
2.6	0.341	398.00	0.472	0.206	0.069200	0.875
2.7	0.297	501.00	0.472	0.226	0.028700	0.915
2.8	0.228	631.00	0.554	0.180	0.201000	0.906
2.9	0.175	794.00	0.554	0.207	0.148000	0.960
3.0	0.159	1000.00	0.554	0.220	0.123000	0.985
3.1	0.120	1260.00	0.711	0.178	0.363000	1.060

IgG3 V1V2 C.1086-gp70

Monotone

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.00870	0.00104	0.006660	0.0107
0.1	0.9660	1.26	0.00861	0.00123	0.006190	0.0110
0.2	0.9650	1.58	0.00861	0.00124	0.006180	0.0110
0.3	0.9650	2.00	0.00861	0.00124	0.006180	0.0110
0.4	0.9600	2.51	0.00861	0.00125	0.006170	0.0110
0.5	0.9580	3.16	0.00861	0.00125	0.006160	0.0111
0.6	0.9570	3.98	0.00852	0.00123	0.006120	0.0109
0.7	0.9510	5.01	0.00852	0.00124	0.006100	0.0109
0.8	0.9430	6.31	0.00852	0.00124	0.006090	0.0110
0.9	0.9400	7.94	0.00852	0.00126	0.006050	0.0110
1.0	0.9340	10.00	0.00852	0.00128	0.006020	0.0110
1.1	0.9250	12.60	0.00852	0.00130	0.005980	0.0111
1.2	0.9200	15.80	0.00846	0.00128	0.005960	0.0110
1.3	0.9170	20.00	0.00846	0.00127	0.005960	0.0110
1.4	0.9090	25.10	0.00846	0.00131	0.005900	0.0110
1.5	0.8860	31.60	0.00846	0.00129	0.005940	0.0110
1.6	0.8750	39.80	0.00846	0.00129	0.005940	0.0110
1.7	0.8520	50.10	0.00846	0.00132	0.005870	0.0111
1.8	0.8350	63.10	0.00846	0.00133	0.005860	0.0111
1.9	0.8310	79.40	0.00846	0.00138	0.005760	0.0112
2.0	0.8020	100.00	0.00846	0.00135	0.005820	0.0111
2.1	0.7610	126.00	0.00846	0.00140	0.005710	0.0112
2.2	0.7050	158.00	0.00846	0.00147	0.005580	0.0113
2.3	0.6510	200.00	0.00846	0.00155	0.005420	0.0115
2.4	0.6130	251.00	0.00846	0.00166	0.005200	0.0117
2.5	0.5550	316.00	0.00846	0.00182	0.004900	0.0120
2.6	0.4990	398.00	0.00846	0.00184	0.004850	0.0121
2.7	0.4260	501.00	0.00846	0.00211	0.004320	0.0126
2.8	0.3480	631.00	0.00846	0.00261	0.003350	0.0136
2.9	0.2870	794.00	0.00846	0.00288	0.002810	0.0141
3.0	0.2430	1000.00	0.00846	0.00326	0.002070	0.0149
3.1	0.2000	1260.00	0.00846	0.00319	0.002210	0.0147
3.2	0.1500	1580.00	0.00703	0.00287	0.001400	0.0127
3.3	0.1230	2000.00	0.00703	0.00352	0.000127	0.0139
3.4	0.0939	2510.00	0.00703	0.00453	-0.001840	0.0159
3.5	0.0695	3160.00	0.00703	0.00525	-0.003260	0.0173
3.6	0.0583	3980.00	0.00703	0.00477	-0.002320	0.0164
3.7	0.0421	5010.00	0.00703	0.00565	-0.004060	0.0181
3.8	0.0253	6310.00	0.00703	0.00904	-0.010700	0.0247

Not Monotone

Threshold (log10)	Threshold	rcdf	Estimate	SE	Lower CI	Upper CI
0.0	1.00	1.0000	0.00870	0.00104	6.72e-03	0.0115
0.1	1.26	0.9660	0.00858	0.00123	6.16e-03	0.0110
0.2	1.58	0.9650	0.00860	0.00124	6.17e-03	0.0110
0.3	2.00	0.9650	0.00860	0.00124	6.17e-03	0.0110
0.4	2.51	0.9600	0.00862	0.00125	6.18e-03	0.0111
0.5	3.16	0.9580	0.00865	0.00125	6.20e-03	0.0111
0.6	3.98	0.9570	0.00837	0.00123	5.97e-03	0.0108
0.7	5.01	0.9510	0.00844	0.00124	6.02e-03	0.0109
0.8	6.31	0.9430	0.00842	0.00124	5.98e-03	0.0108
0.9	7.94	0.9400	0.00855	0.00126	6.08e-03	0.0110
1.0	10.00	0.9340	0.00862	0.00128	6.12e-03	0.0111
1.1	12.60	0.9250	0.00875	0.00130	6.20e-03	0.0113
1.2	15.80	0.9200	0.00838	0.00128	5.88e-03	0.0109
1.3	20.00	0.9170	0.00821	0.00127	5.72e-03	0.0107
1.4	25.10	0.9090	0.00841	0.00131	5.85e-03	0.0110
1.5	31.60	0.8860	0.00811	0.00129	5.58e-03	0.0106
1.6	39.80	0.8750	0.00803	0.00129	5.51e-03	0.0106
1.7	50.10	0.8520	0.00816	0.00132	5.56e-03	0.0107
1.8	63.10	0.8350	0.00802	0.00133	5.42e-03	0.0106
1.9	79.40	0.8310	0.00829	0.00138	5.59e-03	0.0110
2.0	100.00	0.8020	0.00779	0.00135	5.15e-03	0.0104
2.1	126.00	0.7610	0.00799	0.00140	5.24e-03	0.0107
2.2	158.00	0.7050	0.00794	0.00147	5.05e-03	0.0108
2.3	200.00	0.6510	0.00809	0.00155	5.05e-03	0.0111
2.4	251.00	0.6130	0.00855	0.00166	5.29e-03	0.0118
2.5	316.00	0.5550	0.00909	0.00182	5.53e-03	0.0126
2.6	398.00	0.4990	0.00856	0.00184	4.95e-03	0.0122
2.7	501.00	0.4260	0.00870	0.00211	4.56e-03	0.0128
2.8	631.00	0.3480	0.01030	0.00261	5.15e-03	0.0154
2.9	794.00	0.2870	0.01020	0.00288	4.55e-03	0.0158
3.0	1000.00	0.2430	0.00943	0.00326	3.04e-03	0.0158
3.1	1260.00	0.2000	0.00933	0.00319	3.08e-03	0.0156
3.2	1580.00	0.1500	0.00647	0.00287	8.45e-04	0.0121
3.3	2000.00	0.1230	0.00758	0.00352	6.85e-04	0.0145
3.4	2510.00	0.0939	0.00890	0.00453	3.07e-05	0.0178
3.5	3160.00	0.0695	0.01130	0.00525	1.03e-03	0.0216
3.6	3980.00	0.0583	0.00945	0.00477	1.01e-04	0.0188
3.7	5010.00	0.0421	0.01020	0.00565	-8.55e-04	0.0213
3.8	6310.00	0.0253	0.01820	0.00904	4.83e-04	0.0359

Vaccine efficacy (monotone)

Threshold (log10)	rcdf	Threshold	Estimate	SE	Lower CI	Upper CI
0.0	1.0000	1.00	0.290	0.113	0.06840	0.511
0.1	0.9660	1.26	0.297	0.125	0.05200	0.542
0.2	0.9650	1.58	0.297	0.125	0.05160	0.542
0.3	0.9650	2.00	0.297	0.125	0.05160	0.542
0.4	0.9600	2.51	0.297	0.126	0.05060	0.543
0.5	0.9580	3.16	0.297	0.126	0.05010	0.544
0.6	0.9570	3.98	0.304	0.124	0.06050	0.547
0.7	0.9510	5.01	0.304	0.125	0.05940	0.548
0.8	0.9430	6.31	0.304	0.125	0.05870	0.549
0.9	0.9400	7.94	0.304	0.127	0.05570	0.552
1.0	0.9340	10.00	0.304	0.127	0.05400	0.553
1.1	0.9250	12.60	0.304	0.129	0.05110	0.556
1.2	0.9200	15.80	0.309	0.127	0.05970	0.558
1.3	0.9170	20.00	0.309	0.127	0.06000	0.557
1.4	0.9090	25.10	0.309	0.129	0.05590	0.562
1.5	0.8860	31.60	0.309	0.128	0.05810	0.559
1.6	0.8750	39.80	0.309	0.128	0.05840	0.559
1.7	0.8520	50.10	0.309	0.130	0.05360	0.564
1.8	0.8350	63.10	0.309	0.130	0.05320	0.564
1.9	0.8310	79.40	0.309	0.134	0.04630	0.571
2.0	0.8020	100.00	0.309	0.132	0.05000	0.568
2.1	0.7610	126.00	0.309	0.136	0.04290	0.575
2.2	0.7050	158.00	0.309	0.140	0.03350	0.584
2.3	0.6510	200.00	0.309	0.146	0.02220	0.595
2.4	0.6130	251.00	0.309	0.154	0.00689	0.611
2.5	0.5550	316.00	0.309	0.165	-0.01480	0.632
2.6	0.4990	398.00	0.309	0.167	-0.01850	0.636
2.7	0.4260	501.00	0.309	0.187	-0.05810	0.676
2.8	0.3480	631.00	0.309	0.225	-0.13200	0.750
2.9	0.2870	794.00	0.309	0.246	-0.17400	0.792
3.0	0.2430	1000.00	0.309	0.276	-0.23300	0.850
3.1	0.2000	1260.00	0.309	0.270	-0.22100	0.839
3.2	0.1500	1580.00	0.426	0.242	-0.04820	0.901
3.3	0.1230	2000.00	0.426	0.294	-0.15000	1.000
3.4	0.0939	2510.00	0.426	0.375	-0.30800	1.160
3.5	0.0695	3160.00	0.426	0.433	-0.42300	1.270
3.6	0.0583	3980.00	0.426	0.394	-0.34700	1.200
3.7	0.0421	5010.00	0.426	0.466	-0.48700	1.340
3.8	0.0253	6310.00	0.426	0.741	-1.03000	1.880